Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis
CONCLUSION: Styrax treatment could ameliorate ischemic-stroke rats by intervening with energy metabolism and glutamine metabolism. This can help us understand the mechanism of styrax, inspiring more clinical application and promotion.PMID:37621078 | PMC:PMC10461497 | DOI:10.1080/13880209.2023.2246501 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Fei Mu Rui Lin Xueyan Lu Meina Zhao Jiaxin Zhao Shaojie Huang Chao Guo Yue Guan Haiyue Zhang Miaomiao Xi Jingwen Wang Haifeng Tang Source Type: research
Tormentic acid, a triterpenoid isolated from the fruits of < em > Chaenomeles speciose < /em > , protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway
CONCLUSIONS: TA may have potential use as a clinical drug candidate for gastric mucosal lesion treatment.PMID:37623313 | PMC:PMC10461523 | DOI:10.1080/13880209.2023.2249526 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jun-Yu He Jie Li Yuan-Yuan Zhang Hai-Bo He Yu-Min He Dao-Xiang Xu Xiao Wang Hao-Yang Wu Ji-Hong Zhang Hasan Jahid Akter Sadia Hui-Fan Yu Jun-Zhi Wang Kun Zou Source Type: research
(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1
CONCLUSION: Our findings indicate that EGCG promotes intestinal epithelial cell proliferation and barrier function after I/R injury in vitro and in vivo via activation of Nurr1.PMID:37621064 | DOI:10.1080/13880209.2023.2245445 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jiacheng Gao Yuhang Wang Zirui Jia Jiaming Xue Tingting Zhou Guo Zu Source Type: research
Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis
CONCLUSION: Styrax treatment could ameliorate ischemic-stroke rats by intervening with energy metabolism and glutamine metabolism. This can help us understand the mechanism of styrax, inspiring more clinical application and promotion.PMID:37621078 | DOI:10.1080/13880209.2023.2246501 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Fei Mu Rui Lin Xueyan Lu Meina Zhao Jiaxin Zhao Shaojie Huang Chao Guo Yue Guan Haiyue Zhang Miaomiao Xi Jingwen Wang Haifeng Tang Source Type: research
Tormentic acid, a triterpenoid isolated from the fruits of < em > Chaenomeles speciose < /em > , protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway
CONCLUSIONS: TA may have potential use as a clinical drug candidate for gastric mucosal lesion treatment.PMID:37623313 | DOI:10.1080/13880209.2023.2249526 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jun-Yu He Jie Li Yuan-Yuan Zhang Hai-Bo He Yu-Min He Dao-Xiang Xu Xiao Wang Hao-Yang Wu Ji-Hong Zhang Hasan Jahid Akter Sadia Hui-Fan Yu Jun-Zhi Wang Kun Zou Source Type: research
(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1
CONCLUSION: Our findings indicate that EGCG promotes intestinal epithelial cell proliferation and barrier function after I/R injury in vitro and in vivo via activation of Nurr1.PMID:37621064 | DOI:10.1080/13880209.2023.2245445 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jiacheng Gao Yuhang Wang Zirui Jia Jiaming Xue Tingting Zhou Guo Zu Source Type: research
Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis
CONCLUSION: Styrax treatment could ameliorate ischemic-stroke rats by intervening with energy metabolism and glutamine metabolism. This can help us understand the mechanism of styrax, inspiring more clinical application and promotion.PMID:37621078 | DOI:10.1080/13880209.2023.2246501 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Fei Mu Rui Lin Xueyan Lu Meina Zhao Jiaxin Zhao Shaojie Huang Chao Guo Yue Guan Haiyue Zhang Miaomiao Xi Jingwen Wang Haifeng Tang Source Type: research
Tormentic acid, a triterpenoid isolated from the fruits of < em > Chaenomeles speciose < /em > , protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway
CONCLUSIONS: TA may have potential use as a clinical drug candidate for gastric mucosal lesion treatment.PMID:37623313 | DOI:10.1080/13880209.2023.2249526 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jun-Yu He Jie Li Yuan-Yuan Zhang Hai-Bo He Yu-Min He Dao-Xiang Xu Xiao Wang Hao-Yang Wu Ji-Hong Zhang Hasan Jahid Akter Sadia Hui-Fan Yu Jun-Zhi Wang Kun Zou Source Type: research
(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1
CONCLUSION: Our findings indicate that EGCG promotes intestinal epithelial cell proliferation and barrier function after I/R injury in vitro and in vivo via activation of Nurr1.PMID:37621064 | DOI:10.1080/13880209.2023.2245445 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jiacheng Gao Yuhang Wang Zirui Jia Jiaming Xue Tingting Zhou Guo Zu Source Type: research
Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis
CONCLUSION: Styrax treatment could ameliorate ischemic-stroke rats by intervening with energy metabolism and glutamine metabolism. This can help us understand the mechanism of styrax, inspiring more clinical application and promotion.PMID:37621078 | DOI:10.1080/13880209.2023.2246501 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Fei Mu Rui Lin Xueyan Lu Meina Zhao Jiaxin Zhao Shaojie Huang Chao Guo Yue Guan Haiyue Zhang Miaomiao Xi Jingwen Wang Haifeng Tang Source Type: research
Tormentic acid, a triterpenoid isolated from the fruits of < em > Chaenomeles speciose < /em > , protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway
CONCLUSIONS: TA may have potential use as a clinical drug candidate for gastric mucosal lesion treatment.PMID:37623313 | DOI:10.1080/13880209.2023.2249526 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jun-Yu He Jie Li Yuan-Yuan Zhang Hai-Bo He Yu-Min He Dao-Xiang Xu Xiao Wang Hao-Yang Wu Ji-Hong Zhang Hasan Jahid Akter Sadia Hui-Fan Yu Jun-Zhi Wang Kun Zou Source Type: research
Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets
CONCLUSIONS: A variety of natural products, such as flavonoids, terpenoids, phenols, and alkaloids, were identified, which could be used as potential SASR-Cov-2 inhibitors. These shed new light on the efficient discovery of SASR-Cov-2 inhibitors from natural products.PMID:37605622 | PMC:PMC10446791 | DOI:10.1080/13880209.2023.2241518 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 22, 2023 Category: Drugs & Pharmacology Authors: Zhouman He Jia Yuan Yuanwen Zhang Runfeng Li Meilan Mo Yutao Wang Huihui Ti Source Type: research
Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren's syndrome (SS) using network pharmacology and animal experiment
CONCLUSION: ZYD has anti-inflammatory and anti-apoptotic effects on SS, which provides a theoretical basis for the treatment of SS with ZYD.PMID:37606264 | PMC:PMC10446814 | DOI:10.1080/13880209.2023.2248188 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 22, 2023 Category: Drugs & Pharmacology Authors: Jiake Yu Shuying Wang Jie Yang Wuxinrui Huang Beikang Tang Weijun Peng Jing Tian Source Type: research
Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer
CONCLUSIONS: Gemcitabine could modulate the pharmacokinetics of DBD's major components by increasing intestinal permeability, enhancing transporter expression, and down-regulating CYP3A. These findings provide critical information for clinical research on DBD as an adjuvant for NSCLC with gemcitabine and help make potential dosage adjustments more scientifically and rationally.PMID:37606265 | PMC:PMC10446811 | DOI:10.1080/13880209.2023.2246500 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 22, 2023 Category: Drugs & Pharmacology Authors: Xin Xu Xi-Yang Sun Ming Chang Zhao-Liang Hu Ting-Ting Cheng Tai-Jun Hang Min Song Source Type: research
Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets
CONCLUSIONS: A variety of natural products, such as flavonoids, terpenoids, phenols, and alkaloids, were identified, which could be used as potential SASR-Cov-2 inhibitors. These shed new light on the efficient discovery of SASR-Cov-2 inhibitors from natural products.PMID:37605622 | PMC:PMC10446791 | DOI:10.1080/13880209.2023.2241518 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 22, 2023 Category: Drugs & Pharmacology Authors: Zhouman He Jia Yuan Yuanwen Zhang Runfeng Li Meilan Mo Yutao Wang Huihui Ti Source Type: research
