Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment
CONCLUSIONS: The TCM intervention has shown the potential to inhibit the expression of inflammatory cytokines and various growth factors, lower blood glucose levels, and significantly affect insulin resistance, lipid metabolism, and improved renal function. Furthermore, the efficacy of TCM can be optimized by tailoring personalized treatment regimens based on the unique profiles of individual patients. We anticipate further rigorous and comprehensive clinical and foundational investigations into the mechanisms underlying the role of TCM in treating DKD.PMID:38357845 | DOI:10.1080/13880209.2024.2314705 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 15, 2024 Category: Drugs & Pharmacology Authors: Shiyi Shen Huiyun Zhong Xiaoshi Zhou Guolin Li Changji Zhang Yulian Zhu Yong Yang Source Type: research
Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of < em > Andrographis paniculata < /em > formulations in beagle dogs
CONCLUSION: The combination of solubilizing agents and a bioenhancer improved the oral bioavailability and pharmacokinetics of andrographolide, indicating potential implications for A. paniculata formulations and clinical therapeutic benefits. Further investigation in clinical studies is warranted.PMID:38351624 | PMC:PMC10868414 | DOI:10.1080/13880209.2024.2311201 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 14, 2024 Category: Drugs & Pharmacology Authors: Phanit Songvut Tussapon Boonyarattanasoonthorn Nitra Nuengchamnong Thammaporn Junsai Teetat Kongratanapasert Kittitach Supannapan Phisit Khemawoot Source Type: research
Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes
CONCLUSIONS: The inhibition of CYP450s by physcion should be considered in its clinical prescription, and the study design can be employed to evaluate the interaction of CYP450s with other herbs.PMID:38353248 | PMC:PMC10868446 | DOI:10.1080/13880209.2024.2314089 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 14, 2024 Category: Drugs & Pharmacology Authors: Lu Liu Sen Sun Xiaohua Li Source Type: research
Homogeneous < em > Polyporus < /em > polysaccharide exerts anti-bladder cancer effects via autophagy induction
CONCLUSIONS: HPP induced bladder cancer cell autophagy by regulating macrophages in the co-culture system, resulting in the inhibition of cancer cell proliferation. The PI3K/Akt/mTOR pathway was involved in HPP-induced autophagy in the co-culture system.PMID:38353262 | PMC:PMC10868468 | DOI:10.1080/13880209.2024.2316195 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 14, 2024 Category: Drugs & Pharmacology Authors: Siwan Luo Xiaopeng Huang Shiqi Li Yuwen Chen Xian Zhang Xing Zeng Source Type: research
Effects of total coumarins from < em > Pileostegia tomentella < /em > on exosomal miRNA expression and angiogenesis in colorectal cancer cells
CONCLUSION: TCPT exhibits anti-angiogenesis in CRC, possibly through upregulating exosomal miR-375-3p. Our findings will shed light on new target exosomes miRNA-mediated tumour microenvironment and the therapeutic application of Pileostegia tomentella in CRC.PMID:38347502 | PMC:PMC10866057 | DOI:10.1080/13880209.2024.2309871 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 12, 2024 Category: Drugs & Pharmacology Authors: Ying Liu Dao-Hai Cheng Zheng-Ying Su Ji-Hua Lv Li Wang Yu-Yin Deng Li Li Source Type: research
Cephaeline promotes ferroptosis by targeting NRF2 to exert anti-lung cancer efficacy
CONCLUSION: We demonstrated for the first time that cephaeline inhibits NRF2, leading to ferroptosis in lung cancer cells. These findings may contribute to the development of innovative therapeutics for lung cancer.PMID:38339810 | PMC:PMC10860416 | DOI:10.1080/13880209.2024.2309891 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 10, 2024 Category: Drugs & Pharmacology Authors: Peng Chen Qingxuan Ye Shang Liang Linghui Zeng Source Type: research
Comparative efficacy and safety of Chinese medicine injections as an adjunctive therapy for cervical cancer in Chinese patients: a network meta-analysis
CONCLUSIONS: The optimal recommendation depends on whether CMIs are used with radiotherapy or concurrent chemoradiotherapy. More high-quality RCTs are needed to confirm further and update the existing evidence.PMID:38334090 | PMC:PMC10860435 | DOI:10.1080/13880209.2024.2312217 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 9, 2024 Category: Drugs & Pharmacology Authors: Fei Ma Qun Wang Di Zhang Zihong Wang Hui Xie Xianghong Liu Hongxing Zhang Haiyan Song Shiguang Sun Source Type: research
The effect of Jian Gan powder on the proliferation, migration and polarization of macrophages and relative mechanism
CONCLUSIONS: JGP effectively suppressed the cellular function of RAW264.7 cells by down-regulating the IL-6/STAT3 signaling pathway and modulating macrophage M1/M2 polarization. These findings provide valuable theoretical and experimental basis for considering the potential clinical application of JGP in the treatment of immune-mediated liver injury in clinical practice.PMID:38327157 | PMC:PMC10854435 | DOI:10.1080/13880209.2024.2309864 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 8, 2024 Category: Drugs & Pharmacology Authors: Kun Li Xue Zheng Jian Zhang Zhanpeng Yan Yu Ji Fei Ge Fangshi Zhu Source Type: research
A comprehensive review of antimalarial medicinal plants used by Tanzanians
CONCLUSIONS: The study discloses a wealth of antimalarial MPs possessed by Tanzanians and suggests a need for research to authenticate the healing potential of antimalarial compounds from the unstudied MPs. Additionally, it indicates that some of the presented MPs are potential sources for developing safe, effective and affordable antimalarial drugs.PMID:38270178 | PMC:PMC10812860 | DOI:10.1080/13880209.2024.2305453 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 25, 2024 Category: Drugs & Pharmacology Authors: David Sylvester Kacholi Source Type: research
Potential mechanism of Qinggong Shoutao pill alleviating age-associated memory decline based on integration strategy
CONCLUSIONS: This study not only provides new insights into the mechanism of QGSTW in the treatment of AAMI but also provides important information and new research ideas for the discovery of traditional Chinese medicine compounds that can treat AAMI.PMID:38145345 | PMC:PMC10763866 | DOI:10.1080/13880209.2023.2291689 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - December 25, 2023 Category: Drugs & Pharmacology Authors: Guiyun Pan Lijuan Chai Rui Chen Qing Yuan Zhihui Song Wanying Feng Jinna Wei Zhihua Yang Yuhang Zhang Guinan Xie An Yan Qingbo Lv Caijun Wang Yingqiang Zhao Yi Wang Source Type: research
