Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of < em > Andrographis paniculata < /em > formulations in beagle dogs

CONCLUSION: The combination of solubilizing agents and a bioenhancer improved the oral bioavailability and pharmacokinetics of andrographolide, indicating potential implications for A. paniculata formulations and clinical therapeutic benefits. Further investigation in clinical studies is warranted.PMID:38351624 | PMC:PMC10868414 | DOI:10.1080/13880209.2024.2311201

Source: Pharmaceutical Biology - February 14, 2024 Category: Drugs & Pharmacology Authors: Phanit Songvut Tussapon Boonyarattanasoonthorn Nitra Nuengchamnong Thammaporn Junsai Teetat Kongratanapasert Kittitach Supannapan Phisit Khemawoot Source Type: research