A Patient Perspective on Genetic Testing for ADPKD: The Lack of Complete Genetic Information, Especially Early in the Course of the Disease, Is Harming Adult Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients.
PMID: 32732372 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 30, 2020 Category: Urology & Nephrology Authors: Odland D Tags: Clin J Am Soc Nephrol Source Type: research

The Early Days: The Postkidney Transplant Recipients' COVID-19 Journey.
PMID: 32727854 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 29, 2020 Category: Urology & Nephrology Authors: Roberts GV, Gee PO Tags: Clin J Am Soc Nephrol Source Type: research

Efficacy and Safety of Daprodustat Compared with Darbepoetin Alfa in Japanese Hemodialysis Patients with Anemia: A Randomized, Double-Blind, Phase 3 Trial.
CONCLUSIONS: Oral daprodustat was noninferior to darbepoetin alfa as measured by mean hemoglobin over weeks 40-52 in Japanese patients receiving hemodialysis switched from ESAs. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: 201754, Clinicaltrials.gov, NCT02969655. PMID: 32723804 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 28, 2020 Category: Urology & Nephrology Authors: Akizawa T, Nangaku M, Yonekawa T, Okuda N, Kawamatsu S, Onoue T, Endo Y, Hara K, Cobitz AR Tags: Clin J Am Soc Nephrol Source Type: research

Developments in the Histopathological Classification of ANCA-Associated Glomerulonephritis.
This study, driven by the original investigators, provides several analyses in order to determine the current position of the histopathologic classification of ANCA-associated GN. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A validation study was performed with newly collected data from 145 patients from ten centers worldwide, including an analysis of interobserver agreement on the histopathologic evaluation of the kidney biopsies. This study also included a meta-analysis on previous validation studies and a validation of the recently proposed ANCA kidney risk score. RESULTS: The validation study showed th...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 28, 2020 Category: Urology & Nephrology Authors: van Daalen EE, Wester Trejo MAC, Göçeroğlu A, Ferrario F, Joh K, Noël LH, Ogawa Y, Wilhelmus S, Ball MJ, Honsova E, Hruskova Z, Kain R, Kimura T, Kollar M, Kronbichler A, Lindhard K, Puéchal X, Salvatore S, Szpirt W, Takizawa H, Tesar V, Berden AE, D Tags: Clin J Am Soc Nephrol Source Type: research

Keeping Up with the Times: Prognostic Tools in ANCA-Associated Glomerulonephritis.
PMID: 32723806 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 28, 2020 Category: Urology & Nephrology Authors: Brix SR, Geetha D Tags: Clin J Am Soc Nephrol Source Type: research

The Role of Incremental Peritoneal Dialysis in the Era of the Advancing American Kidney Health Initiative.
PMID: 32709617 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 24, 2020 Category: Urology & Nephrology Authors: Reddy YNV, Mendu ML Tags: Clin J Am Soc Nephrol Source Type: research

Klotho in Clinical Nephrology: Diagnostic and Therapeutic Implications.
Abstract αKlotho (called Klotho here) is a membrane protein that serves as the coreceptor for the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and released as a circulating substance originating primarily from the kidney and exerts a myriad of housekeeping functions in just about every organ. The vital role of Klotho is shown by the multiorgan failure with genetic deletion in rodents, with certain features reminiscent of human disease. The most common causes of systemic Klotho deficiency are AKI and CKD. Preclinical data on Klotho biology have advanced considerably and demo...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 22, 2020 Category: Urology & Nephrology Authors: Neyra JA, Hu MC, Moe OW Tags: Clin J Am Soc Nephrol Source Type: research

Effect of Ferric Citrate versus Ferrous Sulfate on Iron and Phosphate Parameters in Patients with Iron Deficiency and CKD: A Randomized Trial.
CONCLUSIONS: As compared with ferrous sulfate, treatment with ferric citrate for 12 weeks resulted in a greater mean increase in TSAT and ferritin concentrations in individuals with moderate to severe CKD and iron deficiency. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Impact of Ferric Citrate vs Ferrous Sulfate on Iron Parameters and Hemoglobin in Individuals With Moderate to Severe Chronic Kidney Disease (CKD) With Iron Deficiency, NCT02888171. PMID: 32694162 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 21, 2020 Category: Urology & Nephrology Authors: Womack R, Berru F, Panwar B, Gutiérrez OM Tags: Clin J Am Soc Nephrol Source Type: research

Utilization and Outcomes of Single and Dual Kidney Transplants from Older Deceased Donors in the United Kingdom.
We examined utilization rates of kidneys retrieved from deceased donors aged ≥60 years, and 5-year patient and death-censored graft survival of recipients of dual and single kidney transplants. Secondary outcomes included eGFR. Multivariable analyses and propensity score analysis were used to correct for differences between the groups. RESULTS: During the study period, 7841 kidneys were procured from deceased donors aged ≥60 years, of which 1338 (17%) were discarded; 356 dual and 5032 single kidneys were transplanted. Donors of dual transplants were older (median, 73 versus 66 years; P
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 20, 2020 Category: Urology & Nephrology Authors: Ibrahim M, Greenhall GHB, Summers DM, Mumford L, Johnson R, Baker RJ, Forsythe J, Pettigrew GJ, Ahmad N, Callaghan CJ Tags: Clin J Am Soc Nephrol Source Type: research

Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.
Abstract Autosomal dominant polycystic kidney disease is the most common monogenic cause of ESKD. Genetic studies from patients and animal models have informed disease pathobiology and strongly support a "threshold model" in which cyst formation is triggered by reduced functional polycystin dosage below a critical threshold within individual tubular epithelial cells due to (1) germline and somatic PKD1 and/or PKD2 mutations, (2) mutations of genes (e.g., SEC63, SEC61B, GANAB, PRKCSH, DNAJB11, ALG8, and ALG9) in the endoplasmic reticulum protein biosynthetic pathway, or (3) somatic mosaicism. Genetic test...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 20, 2020 Category: Urology & Nephrology Authors: Lanktree MB, Haghighi A, di Bari I, Song X, Pei Y Tags: Clin J Am Soc Nephrol Source Type: research

Cuffless Blood Pressure Monitoring: Promises and Challenges.
Abstract Current BP measurements are on the basis of traditional BP cuff approaches. Ambulatory BP monitoring, at 15- to 30-minute intervals usually over 24 hours, provides sufficiently continuous readings that are superior to the office-based snapshot, but this system is not suitable for frequent repeated use. A true continuous BP measurement that could collect BP passively and frequently would require a cuffless method that could be worn by the patient, with the data stored electronically much the same way that heart rate and heart rhythm are already done routinely. Ideally, BP should be measured continuously an...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 17, 2020 Category: Urology & Nephrology Authors: Pandit JA, Lores E, Batlle D Tags: Clin J Am Soc Nephrol Source Type: research

Preprint Servers in Kidney Disease Research: A Rapid Review.
Abstract Preprint servers, such as arXiv and bioRxiv, have disrupted the scientific communication landscape by providing rapid access to research before peer review. medRxiv was launched as a free online repository for preprints in the medical, clinical, and related health sciences in 2019. In this review, we present the uptake of preprint server use in nephrology and discuss specific considerations regarding preprint server use in medicine. Distribution of kidney-related research on preprint servers is rising at an exponential rate. Survey of nephrology journals identified that 15 of 17 (88%) are publishing origi...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 17, 2020 Category: Urology & Nephrology Authors: Vlasschaert C, Giles C, Hiremath S, Lanktree MB Tags: Clin J Am Soc Nephrol Source Type: research

GWAS-Based Discoveries in IgA Nephropathy, Membranous Nephropathy, and Steroid Sensitive Nephrotic Syndrome.
Abstract Over the past decade, genome-wide association studies (GWAS) have emerged as a powerful tool to understand the genetic basis of complex traits in humans. The GWAS approach has been successfully applied to primary glomerular disorders, providing numerous novel insights into the genetic architecture of IgA nephropathy, membranous nephropathy, and steroid-sensitive nephrotic syndrome. IgA nephropathy appears to have a highly complex polygenic architecture, with nearly 20 genome-wide significant loci of small to moderate effects discovered to date. In contrast, the genetic susceptibility to membranous nephrop...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 17, 2020 Category: Urology & Nephrology Authors: Sanchez-Rodriguez E, Southard CT, Kiryluk K Tags: Clin J Am Soc Nephrol Source Type: research

Comparative Efficacy and Safety of BP-Lowering Pharmacotherapy in Patients Undergoing Maintenance Dialysis: A Network Meta-Analysis of Randomized, Controlled Trials.
CONCLUSIONS: BP-lowering agents significantly reduced systolic BP in patients undergoing maintenance dialysis. β-Blockers and aldosterone antagonists may confer larger reductions, although treatment with aldosterone antagonists may be limited by adverse events. PMID: 32675281 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 16, 2020 Category: Urology & Nephrology Authors: Shaman AM, Smyth B, Arnott C, Palmer SC, Mihailidou AS, Jardine MJ, Gallagher MP, Perkovic V, Jun M Tags: Clin J Am Soc Nephrol Source Type: research

Drug Selection for Treating Hypertension in Dialysis Patients: More to Consider than BP-Lowering Potency.
PMID: 32678800 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 16, 2020 Category: Urology & Nephrology Authors: Shafi T, Miskulin DC Tags: Clin J Am Soc Nephrol Source Type: research

Effects of Intensive Blood Pressure Control in Patients with and without Albuminuria: Post Hoc Analyses from SPRINT.
Abstract BACKGROUND AND OBJECTIVES: It is unclear whether the presence of albuminuria modifies the effects of intensive systolic BP control on risk of eGFR decline, cardiovascular events, or mortality. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Systolic Blood Pressure Intervention Trial randomized nondiabetic adults ≥50 years of age at high cardiovascular risk to a systolic BP target of
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 15, 2020 Category: Urology & Nephrology Authors: Chang AR, Kramer H, Wei G, Boucher R, Grams ME, Berlowitz D, Bhatt U, Cohen DL, Drawz P, Punzi H, Freedman BI, Haley W, Hawfield A, Horwitz E, McLouth C, Morisky D, Papademetriou V, Rocco MV, Wall B, Weiner DE, Zias A, Beddhu S, SPRINT Research Group Tags: Clin J Am Soc Nephrol Source Type: research

Intensive Blood Pressure Lowering Should Be the Goal for Most Individuals at High Risk of Cardiovascular Disease Irrespective of Albuminuria.
PMID: 32669307 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 15, 2020 Category: Urology & Nephrology Authors: Ascher SB, Ix JH Tags: Clin J Am Soc Nephrol Source Type: research

COVID-19 Outbreak and Management Approach for Families with Children on Long-Term Kidney Replacement Therapy.
CONCLUSIONS: The coronavirus disease 2019 outbreak has had physical, mental, logistical, and financial effects on families with children on long-term KRT. PMID: 32665227 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 14, 2020 Category: Urology & Nephrology Authors: Zhao R, Zhou Q, Wang XW, Liu CH, Wang M, Yang Q, Zhai YH, Zhu DQ, Chen J, Fang XY, Tang XS, Zhang H, Shen Q, Xu H Tags: Clin J Am Soc Nephrol Source Type: research

Strategies to Reduce Rehospitalization in Patients with CKD and Kidney Failure.
We describe factors that are specific to the patient, the index hospitalization, and underlying conditions that help identify the "high-risk" patient. Early follow-up care, developing volume management strategies, optimizing nutrition, obtaining palliative care consultations for seriously ill patients during hospitalization and conducting goals-of-care discussions with them, instituting systematic advance care planning during outpatient visits to avoid unwanted hospitalizations and intensive treatment at the end of life, and developing protocols for patients with incident or prevalent cardiovascular conditions ma...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 13, 2020 Category: Urology & Nephrology Authors: Doshi S, Wish JB Tags: Clin J Am Soc Nephrol Source Type: research

Careers in Critical Care Nephrology: Opportunities and Challenges.
PMID: 32646914 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 9, 2020 Category: Urology & Nephrology Authors: Sanghavi SF, Campbell KN Tags: Clin J Am Soc Nephrol Source Type: research

Clinical Genetic Screening in Adult Patients with Kidney Disease.
Abstract Expanded accessibility of genetic sequencing technologies, such as chromosomal microarray and massively parallel sequencing approaches, is changing the management of hereditary kidney diseases. Genetic causes account for a substantial proportion of pediatric kidney disease cases, and with increased utilization of diagnostic genetic testing in nephrology, they are now also detected at appreciable frequencies in adult populations. Establishing a molecular diagnosis can have many potential benefits for patient care, such as guiding treatment, familial testing, and providing deeper insights on the molecular p...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 9, 2020 Category: Urology & Nephrology Authors: Cocchi E, Nestor JG, Gharavi AG Tags: Clin J Am Soc Nephrol Source Type: research

Stepping into the Void: Remunerating, Valuing, and Understanding Nephrologists.
PMID: 32646916 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 9, 2020 Category: Urology & Nephrology Authors: Agarwal A, Ibrahim T Tags: Clin J Am Soc Nephrol Source Type: research

COVID-19 in Patients with Kidney Disease.
PMID: 32636199 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 7, 2020 Category: Urology & Nephrology Authors: Ajaimy M, Melamed ML Tags: Clin J Am Soc Nephrol Source Type: research

APOL1 Nephropathy: From Genetics to Clinical Applications.
Abstract Rates of many types of severe kidney disease are much higher in blacks than most other groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated nephropathy, and other forms of nondiabetic kidney disease. We discuss the population genetics of APOL1 risk variants and the clinical spectrum of APOL1 nephropathy. We then consider clinical issues that arise for the practicing nephrologist caring for the patient who may have ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 2, 2020 Category: Urology & Nephrology Authors: Friedman DJ, Pollak MR Tags: Clin J Am Soc Nephrol Source Type: research

External Validation of the International IgA Nephropathy Prediction Tool.
CONCLUSIONS: In this study, both full models demonstrated remarkable discrimination, acceptable calibration, and satisfactory clinical utility. The relatively short follow-up time may have limited the validation of these models. PMID: 32616496 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 2, 2020 Category: Urology & Nephrology Authors: Zhang J, Huang B, Liu Z, Wang X, Xie M, Guo R, Wang Y, Yu D, Wang P, Zhu Y, Ren J Tags: Clin J Am Soc Nephrol Source Type: research

Long-Term Hemodialysis during the COVID-19 Pandemic.
PMID: 32616497 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 2, 2020 Category: Urology & Nephrology Authors: Gedney N Tags: Clin J Am Soc Nephrol Source Type: research

The Curious Story of Cerebral Salt Wasting: Fact or Fiction?
PMID: 32611661 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 1, 2020 Category: Urology & Nephrology Authors: Verbalis JG Tags: Clin J Am Soc Nephrol Source Type: research

Adverse Drug Reactions in Patients with CKD.
Abstract BACKGROUND AND OBJECTIVES: Little is known about the burden of adverse drug reactions in CKD. We estimated the incidence of overall and serious adverse drug reactions and assessed the probability of causation, preventability, and factors associated with adverse drug reactions in patients seen by nephrologists. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Chronic Kidney Disease-Renal Epidemiology and Information Network cohort included 3033 outpatients (65% men) with CKD and eGFR
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 1, 2020 Category: Urology & Nephrology Authors: Laville SM, Gras-Champel V, Moragny J, Metzger M, Jacquelinet C, Combe C, Fouque D, Laville M, Frimat L, Robinson BM, Stengel B, Massy ZA, Liabeuf S, Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) Study Group Tags: Clin J Am Soc Nephrol Source Type: research

Adverse Drug Effects in Patients with CKD: Primum Non Nocere.
PMID: 32611663 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 1, 2020 Category: Urology & Nephrology Authors: Perazella MA, Nolin TD Tags: Clin J Am Soc Nephrol Source Type: research

The Importance of Kidney Medullary Tissue for the Accurate Diagnosis of BK Virus Allograft Nephropathy.
Abstract BACKGROUND AND OBJECTIVES: The published tissue adequacy requirement of kidney medulla for BK virus allograft nephropathy diagnosis lacks systematic verification and competes against potential increased procedural risks from deeper sampling. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We evaluated whether the presence of kidney medulla improved the diagnostic rate of BK nephropathy in 2244 consecutive biopsy samples from 856 kidney transplants with detailed histologic and virologic results. RESULTS: Medulla was present in 821 samples (37%) and correlated with maximal core length (r=0.35; P
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 29, 2020 Category: Urology & Nephrology Authors: Nankivell BJ, Renthawa J, Shingde M, Khan A Tags: Clin J Am Soc Nephrol Source Type: research

Individualizing Treatment of Steroid-Resistant Nephrotic Syndrome: Registries to the Fore.
PMID: 32601094 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 29, 2020 Category: Urology & Nephrology Authors: Bagga A, Sinha A Tags: Clin J Am Soc Nephrol Source Type: research

Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis.
CONCLUSIONS: Mitochondrial dysfunction is due to multifactorial etiologies and presents prior to the initiation of maintenance hemodialysis, including in patients with CKD stages 3-5. PMID: 32591419 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 26, 2020 Category: Urology & Nephrology Authors: Gamboa JL, Roshanravan B, Towse T, Keller CA, Falck AM, Yu C, Frontera WR, Brown NJ, Ikizler TA Tags: Clin J Am Soc Nephrol Source Type: research

Role of Skeletal Muscle Mitochondrial Dysfunction in CKD.
PMID: 32591420 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 26, 2020 Category: Urology & Nephrology Authors: Ryan AS Tags: Clin J Am Soc Nephrol Source Type: research

Patient and Caregiver Perspectives on Terms Used to Describe Kidney Health.
CONCLUSIONS: The obscurity and imprecision of terms in CKD can be unduly distressing and traumatizing for patients, which can impair decision making and self-management. Consistent and meaningful patient-centered terminology may improve patient autonomy, satisfaction, and outcomes. PMID: 32586923 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 25, 2020 Category: Urology & Nephrology Authors: Tong A, Levey AS, Eckardt KU, Anumudu S, Arce CM, Baumgart A, Dunn L, Gutman T, Harris T, Lightstone L, Scholes-Robertson N, Shen JI, Wheeler DC, White DM, Wilkie M, Craig JC, Jadoul M, Winkelmayer WC Tags: Clin J Am Soc Nephrol Source Type: research

Metabolic Alkalosis: A Brief Pathophysiologic Review.
Abstract Metabolic alkalosis is a very commonly encountered acid-base disorder that may be generated by a variety of exogenous and/or endogenous, pathophysiologic mechanisms. Multiple mechanisms are also responsible for the persistence, or maintenance, of metabolic alkalosis. Understanding these generation and maintenance mechanisms helps direct appropriate intervention and correction of this disorder. The framework utilized in this review is based on the ECF volume-centered approach popularized by Donald Seldin and Floyd Rector in the 1970s.  Although many subsequent scientific discoveries have advanced our ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 25, 2020 Category: Urology & Nephrology Authors: Emmett M Tags: Clin J Am Soc Nephrol Source Type: research

Nephrology Nomenclature: How to Accelerate Patient Anxiety, Suppress Engagement, and Mire the Advance of Medical Innovation.
PMID: 32586925 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 25, 2020 Category: Urology & Nephrology Authors: Conway PT Tags: Clin J Am Soc Nephrol Source Type: research

Health Policy for Dialysis Care in Canada and the United States.
This article compares and contrasts transnational dialysis-related health policies, focusing on key levers including payment, finance, regulation, and organization. We also describe how policy levers can incentivize favorable practice patterns to support high-quality/high-value, person-centered care and to catalyze the emergence of transformative technologies for alternative kidney replacement strategies. PMID: 32586926 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 25, 2020 Category: Urology & Nephrology Authors: Tonelli M, Vanholder R, Himmelfarb J Tags: Clin J Am Soc Nephrol Source Type: research

Considering Our Patients and Tempering Terminology.
PMID: 32588823 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 25, 2020 Category: Urology & Nephrology Authors: Ingelfinger JR Tags: Clin J Am Soc Nephrol Source Type: research

The Electronic Medical Record and Nephrology Fellowship Education in the United States: An Opinion Survey.
CONCLUSIONS: Respondents reported that the electronic medical record enhances fellow education with efficient and geographically flexible patient data access, but the time demands of data and order entry reduce engagement in educational activities, contribute to work-hours violations, and diminish direct patient interactions. PMID: 32576553 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 23, 2020 Category: Urology & Nephrology Authors: Yuan CM, Little DJ, Marks ES, Watson MA, Raghavan R, Nee R, Nephrology Education Research and Development Consortium—NERDC Tags: Clin J Am Soc Nephrol Source Type: research

From Nihilism to Opportunity: The Educational Potential of the Electronic Health Record.
PMID: 32579129 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 23, 2020 Category: Urology & Nephrology Authors: Olson APJ, Rosenberg ME Tags: Clin J Am Soc Nephrol Source Type: research

Racial Differences in Risk Factors for Kidney Stone Formation.
Abstract BACKGROUND AND OBJECTIVES: Incidence of kidney stone disease is rising. It is not known whether mechanisms of stone formation differ across racial groups. Our objective was to identify differing lithogenic risk factors across racial groups in idiopathic nephrolithiasis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective cohort study evaluating metabolic risk factors in black and age-matched white idiopathic stone formers at our tertiary referral center. We compared serum and urine metabolic risk factors pre- and post-treatment across racial groups using analysis of covari...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 19, 2020 Category: Urology & Nephrology Authors: Zisman AL, Coe FL, Cohen AJ, Riedinger CB, Worcester EM Tags: Clin J Am Soc Nephrol Source Type: research

Mortality and Recovery Associated with Kidney Failure Due to Acute Kidney Injury.
CONCLUSIONS: Kidney failure due to AKI confers a higher risk of mortality in the first 6 months compared with kidney failure due to diabetes or other causes. Recovery within 12 months is common, although less so among women than men and among black, Asian, Hispanic, and Native American patients than white patients. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_06_17_CJN11200919.mp3. PMID: 32554731 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2020 Category: Urology & Nephrology Authors: Shah S, Leonard AC, Harrison K, Meganathan K, Christianson AL, Thakar CV Tags: Clin J Am Soc Nephrol Source Type: research

Urinary Lithogenic Risk Profile in ADPKD Patients Treated with Tolvaptan.
Abstract BACKGROUND AND OBJECTIVES: Nephrolithiasis is a common health problem in autosomal dominant polycystic kidney disease (ADPKD) and significantly contributes to patient morbidity. Recently, Tolvaptan has been introduced for the treatment of ADPKD, but whether it is associated with alterations of the urinary lithogenic risk profile remains unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted an analysis of participants enrolled in the Bern ADPKD registry, a prospective observational cohort study. Twenty-four-hour urine analyses were performed at baseline and then at yearly follow-ups...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 11, 2020 Category: Urology & Nephrology Authors: Bargagli M, Dhayat NA, Anderegg M, Semmo M, Huynh-Do U, Vogt B, Ferraro PM, Fuster DG Tags: Clin J Am Soc Nephrol Source Type: research

Delivering High-Quality Peritoneal Dialysis: What Really Matters?
PMID: 32527946 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 11, 2020 Category: Urology & Nephrology Authors: Teitelbaum I Tags: Clin J Am Soc Nephrol Source Type: research

ADPKD, Tolvaptan, and Nephrolithiasis Risk.
PMID: 32527947 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 11, 2020 Category: Urology & Nephrology Authors: Hoorn EJ, Zietse R Tags: Clin J Am Soc Nephrol Source Type: research

Decision Algorithm for Prescribing SGLT2 Inhibitors and GLP-1 Receptor Agonists for Diabetic Kidney Disease.
Abstract Diabetic kidney disease and its comorbid conditions, including atherosclerotic cardiovascular disease, heart failure, diabetes, and obesity, are interconnected conditions that compound the risk of kidney failure and cardiovascular mortality, and exponentiate health care costs. Sodium glucose cotransporter 2 inhibitor (SGLT2i) and glucagon-like peptide 1 receptor agonist (GLP-1 RA) are novel diabetes medications that prevent cardiovascular events and kidney failure. Clinical trials exploring the cardiovascular and kidney outcomes of SGLT2i and GLP-1 RA have fundamentally shifted the treatment paradigm of d...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 9, 2020 Category: Urology & Nephrology Authors: Li J, Albajrami O, Zhuo M, Hawley CE, Paik JM Tags: Clin J Am Soc Nephrol Source Type: research

Correction.
Authors: PMID: 32518101 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 9, 2020 Category: Urology & Nephrology Tags: Clin J Am Soc Nephrol Source Type: research

Complexities of Understanding Function from CKD-Associated DNA Variants.
Abstract Genome-wide association studies (GWASs) have facilitated the unbiased discovery of hundreds of genomic loci associated with CKD and kidney function. The vast majority of disease-associated DNA variants are noncoding. Those that are causal in CKD pathogenesis likely modulate transcription of target genes in a cell type-specific manner. To gain novel biological insights into mechanisms driving the development of CKD, the causal variants (which are usually not the most significant variant reported in a GWAS), their target genes, and causal cell types need to be identified. This functional validation requires...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 8, 2020 Category: Urology & Nephrology Authors: Lin J, Susztak K Tags: Clin J Am Soc Nephrol Source Type: research

Dialysis Regret: Prevalence and Correlates.
We report adjusted odd ratios (ORs) and 95% confidence intervals (95% CIs) for the following candidate predictors: knowledge of CKD, attitudes toward CKD treatment, and preference for end-of-life care. RESULTS: Eighty-two of 397 respondents (21%) reported decisional regret. There were no significant demographic correlates of regret. Regret was more common when patients reported choosing dialysis to please doctors or family members (OR, 2.34; 95% CI, 1.27 to 4.31; P
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 4, 2020 Category: Urology & Nephrology Authors: Saeed F, Ladwig SA, Epstein RM, Monk RD, Duberstein PR Tags: Clin J Am Soc Nephrol Source Type: research

Treatment of Granulomatosis with Polyangiitis and Microscopic Polyangiitis: Should Type of ANCA Guide the Treatment?
PMID: 32471814 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 29, 2020 Category: Urology & Nephrology Authors: Tesar V, Hruskova Z Tags: Clin J Am Soc Nephrol Source Type: research