Associations between Deprivation, Geographic Location, and Access to Pediatric Kidney Care in the United Kingdom.
CONCLUSIONS: Socioeconomic deprivation or geographic location are not associated with late presentation in children in the United Kingdom. Geographic location was not independently associated with pre-emptive transplantation; however, children from more affluent areas were more likely to receive a pre-emptive transplant. PMID: 33468533 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 19, 2021 Category: Urology & Nephrology Authors: Plumb LA, Sinha MD, Casula A, Inward CD, Marks SD, Caskey FJ, Ben-Shlomo Y Tags: Clin J Am Soc Nephrol Source Type: research

Mind the Gap: Acknowledging Deprivation Is Key to Narrowing Kidney Health Disparities in Both Children and Adults.
PMID: 33468534 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 19, 2021 Category: Urology & Nephrology Authors: Goldberg AM, Bignall ONR Tags: Clin J Am Soc Nephrol Source Type: research

Exome Chip Analyses and Genetic Risk for IgA Nephropathy among Han Chinese.
Abstract BACKGROUND AND OBJECTIVES: IgA nephropathy is the most common form of primary GN worldwide. The evidence of geographic and ethnic differences, as well as familial aggregation of the disease, supports a strong genetic contribution to IgA nephropathy. Evidence for genetic factors in IgA nephropathy comes also from genome-wide association patient-control studies. However, few studies have systematically evaluated the contribution of coding variation in IgA nephropathy. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a two-stage exome chip-based association study in 13,242 samples, includ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 18, 2021 Category: Urology & Nephrology Authors: Zhou XJ, Tsoi LC, Hu Y, Patrick MT, He K, Berthier CC, Li Y, Wang YN, Qi YY, Zhang YM, Gan T, Li Y, Hou P, Liu LJ, Shi SF, Lv JC, Xu HJ, Zhang H Tags: Clin J Am Soc Nephrol Source Type: research

Variability in Culture-Negative Peritonitis Rates in Pediatric Peritoneal Dialysis Programs in the United States.
Abstract BACKGROUND AND OBJECTIVES: International guidelines suggest a target culture-negative peritonitis rate of 20% (high-rate centers). In addition, centers completed a survey focused on center-specific peritoneal dialysis effluent culture techniques. RESULTS: During the 5.5 years of observation, 1113 patients had 1301 catheters placed, totaling 19,025 patient months. There were 620 episodes of peritonitis in 378 patients with 411 catheters; cultures were negative in 165 (27%) peritonitis episodes from 125 (33%) patients and 128 (31%) catheters. Low-rate centers more frequently placed catheters with a dow...
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 18, 2021 Category: Urology & Nephrology Authors: Davis TK, Bryant KA, Rodean J, Richardson T, Selvarangan R, Qin X, Neu A, Warady BA Tags: Clin J Am Soc Nephrol Source Type: research

Assessing Genetic Risk for IgA Nephropathy: State of the Art.
PMID: 33462085 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 18, 2021 Category: Urology & Nephrology Authors: Prakash S, Gharavi AG Tags: Clin J Am Soc Nephrol Source Type: research

Opportunities for Improvement in Quality of Care of PD-Related Peritonitis in Children.
PMID: 33462086 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 18, 2021 Category: Urology & Nephrology Authors: Vidal E Tags: Clin J Am Soc Nephrol Source Type: research

Trends in Discard of Kidneys from Hepatitis C Viremic Donors in the United States.
CONCLUSIONS: Despite the decrease in kidney discard in recent years, kidneys from viremic (compared with aviremic seronegative) donors still had 48% higher odds of discard in 2019. The potential of these discarded organs to provide successful transplantation should be explored. PMID: 33451990 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 15, 2021 Category: Urology & Nephrology Authors: Chang SH, Merzkani M, Lentine KL, Wang M, Axelrod DA, Anwar S, Schnitzler MA, Wellen J, Chapman WC, Alhamad T Tags: Clin J Am Soc Nephrol Source Type: research

Optimizing Utilization of Kidneys from Hepatitis C-Positive Kidney Donors.
PMID: 33451991 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 15, 2021 Category: Urology & Nephrology Authors: Ariyamuthu VK, Tanriover B Tags: Clin J Am Soc Nephrol Source Type: research

The Pathogenesis of Race and Ethnic Disparities: Targets for Achieving Health Equity.
PMID: 33441463 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 13, 2021 Category: Urology & Nephrology Authors: Powe NR Tags: Clin J Am Soc Nephrol Source Type: research

The Seen and the Unseen: Race and Social Inequities Affecting Kidney Care.
PMID: 33441464 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 13, 2021 Category: Urology & Nephrology Authors: Boulware LE, Mohottige D Tags: Clin J Am Soc Nephrol Source Type: research

Social Determinants of Kidney Health: Focus on Poverty.
PMID: 33441465 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 13, 2021 Category: Urology & Nephrology Authors: Norris KC, Beech BM Tags: Clin J Am Soc Nephrol Source Type: research

Reducing the Burden of CKD among Latinx: A Community-Based Approach.
PMID: 33441466 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 13, 2021 Category: Urology & Nephrology Authors: Pereira RI, Cervantes L Tags: Clin J Am Soc Nephrol Source Type: research

Social Determinants of Health in People with Kidney Disease: An Introduction.
PMID: 33441467 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 13, 2021 Category: Urology & Nephrology Authors: Weinstein AM, Kimmel PL Tags: Clin J Am Soc Nephrol Source Type: research

Personal Experiences of Patients in the Interaction of Culture and Kidney Disease.
ium PMID: 33441468 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 13, 2021 Category: Urology & Nephrology Authors: Cukor D, Edwards DP, New York Academy of Medicine’s 2020 Alison Norris Symposium Tags: Clin J Am Soc Nephrol Source Type: research

Use of Gadolinium in Individuals with Reduced Kidney Function.
PMID: 33431379 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 11, 2021 Category: Urology & Nephrology Authors: Kalantari K, Swaminathan S Tags: Clin J Am Soc Nephrol Source Type: research

eGFR Testing around the World: Justice, Access, and Accuracy.
PMID: 33414152 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 7, 2021 Category: Urology & Nephrology Authors: Jha V, Modi GK Tags: Clin J Am Soc Nephrol Source Type: research

Mass Disasters and Burnout in Nephrology Personnel: From Earthquakes and Hurricanes to COVID-19 Pandemic.
der R Abstract Mass disasters result in extensive health problems and make health care delivery problematic, as has been the case during the COVID-19 pandemic. Although COVID-19 was initially considered a pulmonary problem, it soon became clear that various other organs were involved. Thus, many care providers, including kidney health personnel, were overwhelmed or developed burnout. This review aims to describe the spectrum of burnout in mass disasters and suggests solutions specifically for nephrology personnel by extending previous experience to the COVID-19 pandemic. Burnout (a psychologic response to work-rel...
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 7, 2021 Category: Urology & Nephrology Authors: Sever MS, Ortiz A, Maggiore U, Bac-García E, Vanholder R Tags: Clin J Am Soc Nephrol Source Type: research

Patients with Kidney Disease: Ready to Use Smartphones for Health Care Delivery?
PMID: 33414174 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 31, 2020 Category: Urology & Nephrology Authors: Schmidt L Tags: Clin J Am Soc Nephrol Source Type: research

Mobile Health in Dialysis: The Best Engagement Medium Is the One that's with Patients.
PMID: 33414175 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 31, 2020 Category: Urology & Nephrology Authors: Singh K Tags: Clin J Am Soc Nephrol Source Type: research

Dietary Therapy for Managing Hyperphosphatemia.
PMID: 33380472 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 30, 2020 Category: Urology & Nephrology Authors: Narasaki Y, Rhee CM Tags: Clin J Am Soc Nephrol Source Type: research

NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD.
ME Abstract BACKGROUND AND OBJECTIVES: Genetic variants in NAT8, a liver- and kidney-specific acetyltransferase encoding gene, have been associated with eGFR and CKD in European populations. Higher circulating levels of two NAT8-associated metabolites, N-δ-acetylornithine and N-acetyl-1-methylhistidine, have been linked to lower eGFR and higher risk of incident CKD in the Black population. We aimed to expand upon prior studies to investigate associations between rs13538, a missense variant in NAT8, N-acetylated amino acids, and kidney failure in multiple, well-characterized cohorts. DESIGN, SETTING, PA...
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 30, 2020 Category: Urology & Nephrology Authors: Luo S, Surapaneni A, Zheng Z, Rhee EP, Coresh J, Hung AM, Nadkarni GN, Yu B, Boerwinkle E, Tin A, Arking DE, Steinbrenner I, Schlosser P, Köttgen A, Grams ME Tags: Clin J Am Soc Nephrol Source Type: research

Effect of Phosphate-Specific Diet Therapy on Phosphate Levels in Adults Undergoing Maintenance Hemodialysis: A Systematic Review and Meta-Analysis.
CONCLUSIONS: There is low-quality evidence that monthly diet therapy by a dietitian appears to be a safe and efficacious treatment for persistent hyperphosphatemia in patients on HD. PMID: 33380474 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 30, 2020 Category: Urology & Nephrology Authors: St-Jules DE, Rozga MR, Handu D, Carrero JJ Tags: Clin J Am Soc Nephrol Source Type: research

The Mobile Health Readiness of People Receiving In-Center Hemodialysis and Home Dialysis.
CONCLUSIONS: The majority of patients on dialysis surveyed were ready for, and proficient in, mobile health. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Dialysis mHealth Survey, NCT04177277. PMID: 33355235 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 22, 2020 Category: Urology & Nephrology Authors: Hussein WF, Bennett PN, Pace S, Chen S, Legg V, Atwal J, Sun S, Schiller B Tags: Clin J Am Soc Nephrol Source Type: research

Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis.
CONCLUSIONS: Among individuals receiving maintenance hemodialysis, zolpidem initiators had a higher risk of hospitalized fall-related fracture compared with trazodone initiators. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_12_18_CJN10070620_final.mp3. PMID: 33355192 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 18, 2020 Category: Urology & Nephrology Authors: Assimon MM, Flythe JE Tags: Clin J Am Soc Nephrol Source Type: research

Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial.
CONCLUSIONS: Praliciguat treatment for 12 weeks did not significantly reduce albuminuria compared with placebo in the primary efficacy analysis. Nonetheless, the observed changes in urine albumin-creatinine ratio, BP, and metabolic variables may support further investigation of praliciguat in diabetic kidney disease. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy/Diabetic Kidney Disease as Measured by Albuminuria, NCT03217591. PMID: 33328269 [PubMed - as supplied by publisher] (Source: Clinical Journal of the...
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 16, 2020 Category: Urology & Nephrology Authors: Hanrahan JP, de Boer IH, Bakris GL, Wilson PJ, Wakefield JD, Seferovic JP, Chickering JG, Chien YT, Carlson K, Cressman MD, Currie MG, Milne GT, Profy AT Tags: Clin J Am Soc Nephrol Source Type: research

Availability, Accessibility, and Quality of Conservative Kidney Management Worldwide.
CONCLUSIONS: Overall, conservative kidney management is available in most countries; however, it is not optimally accessible or of the highest quality. PMID: 33323461 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 15, 2020 Category: Urology & Nephrology Authors: Lunney M, Bello AK, Levin A, Tam-Tham H, Thomas C, Osman MA, Ye F, Bellorin-Font E, Benghanem Gharbi M, Ghnaimat M, Htay H, Cho Y, Jha V, Ossareh S, Rondeau E, Sola L, Tchokhonelidze I, Tesar V, Tungsanga K, Kazancioglu RT, Wang AY, Yang CW, Zemchenkov A, Tags: Clin J Am Soc Nephrol Source Type: research

Impact of COVID-19 Pandemic in Children with CKD or Immunosuppression.
hrology, COVID-19 TASK FORCE of the Italian Society of Pediatric Nephrology PMID: 33318026 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 14, 2020 Category: Urology & Nephrology Authors: Mastrangelo A, Morello W, Vidal E, Guzzo I, Annicchiarico Petruzzelli L, Benetti E, Materassi M, Giordano M, Pasini A, Corrado C, Puccio G, Chimenz R, Pecoraro C, Massella L, Peruzzi L, Montini G, COVID-19 Task Force of the Italian Society of Pediatric Ne Tags: Clin J Am Soc Nephrol Source Type: research

Why Is the GFR So High? Implications for the Treatment of Kidney Failure.
Abstract The high GFR in vertebrates obligates large energy expenditure. Homer Smith's teleologic argument that this high GFR was needed to excrete water as vertebrates evolved in dilute seas is outdated. The GFR is proportional to the metabolic rate among vertebrate species and higher in warm-blooded mammals and birds than in cold-blooded fish, amphibians, and reptiles. The kidney clearance of some solutes is raised above the GFR by tubular secretion, and we presume secretion evolved to eliminate particularly toxic compounds. In this regard, high GFRs may provide a fluid stream into which toxic solutes can be rea...
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 10, 2020 Category: Urology & Nephrology Authors: Meyer TW, Hostetter TH Tags: Clin J Am Soc Nephrol Source Type: research

The Influence of Medical School Debt on Career Choices in Nephrology.
PMID: 33288525 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 7, 2020 Category: Urology & Nephrology Authors: Ginsberg C Tags: Clin J Am Soc Nephrol Source Type: research

Prospective Cohort Study of Renin-Angiotensin System Blocker Usage after Hospitalized Acute Kidney Injury.
CONCLUSIONS: The risk-benefit ratio of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker therapy after hospital discharge appears to be similar regardless of whether AKI occurred during the hospitalization. PMID: 33272913 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 3, 2020 Category: Urology & Nephrology Authors: Brar S, Liu KD, Go AS, Hsu RK, Chinchilli VM, Coca SG, Garg AX, Himmelfarb J, Ikizler TA, Kaufman J, Kimmel PL, Parikh CR, Siew ED, Ware LB, Zeng H, Hsu CY, ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) study i Tags: Clin J Am Soc Nephrol Source Type: research

Expression of CD147 and Cyclophilin A in Kidneys of Patients with COVID-19.
PMID: 33268502 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 2, 2020 Category: Urology & Nephrology Authors: Su H, Wan C, Wang ZD, Gao Y, Li YC, Tang F, Zhu HY, Yi LX, Zhang C Tags: Clin J Am Soc Nephrol Source Type: research

Effect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Blacks.
n Medicine Consortium PMID: 33268503 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 2, 2020 Category: Urology & Nephrology Authors: Reiner AP, Raffield LM, Franceschini N, Auer PL, Lange EM, Nickerson DA, Zakai NA, Correa A, Olson N, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium, Natinal Heart, Lung, and Blood Institute Trans-Omics for Precisi Tags: Clin J Am Soc Nephrol Source Type: research

Nephronophthisis in Young Adults Phenocopying Thrombotic Microangiopathy and Severe Nephrosclerosis.
PMID: 33268504 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 2, 2020 Category: Urology & Nephrology Authors: Doreille A, Raymond L, Lebre AS, Linster C, Saraeva Lamri R, Karras A, Khayat R, Michel PA, Buob D, Luque Y, Rafat C, Mesnard L Tags: Clin J Am Soc Nephrol Source Type: research

Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy.
pathy Abstract BACKGROUND AND OBJECTIVES: Patients with membranous nephropathy can have circulating autoantibodies against membrane-bound (phospholipase A2 receptor 1 [PLA2R1] and thrombospondin type-1 domain containing 7A[THSD7A]) and intracellular (aldose reductase, SOD2, and α-enolase) podocyte autoantigens. We studied their combined association with clinical outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Serum levels of anti-PLA2R1, anti-THSD7A, anti-aldose reductase, anti-SOD2, and anti-α-enolase autoantibodies were determined in 285 patients at diagnosis and during follow-up us...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 30, 2020 Category: Urology & Nephrology Authors: Ghiggeri GM, Seitz-Polski B, Justino J, Zaghrini C, Payré C, Brglez V, Dolla G, Sinico A, Scolari F, Vaglio A, Prunotto M, Candiano G, Radice A, Bruschi M, Lambeau G, Italian Study Group for Membranous Nephropathy Tags: Clin J Am Soc Nephrol Source Type: research

Integrating Patient Priorities with Science by Community Engagement in the Kidney Precision Medicine Project.
Kidney Precision Medicine Project Abstract The Kidney Precision Medicine Project (KPMP) is a multisite study designed to improve understanding of CKD attributed to diabetes or hypertension and AKI by performing protocol-driven kidney biopsies. Study participants and their kidney tissue samples undergo state-of-the-art deep phenotyping using advanced molecular, imaging, and data analytical methods. Few patients participate in research design or concepts for discovery science. A major goal of the KPMP is to include patients as equal partners to inform the research for clinically relevant benefit. The purpose of thi...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 30, 2020 Category: Urology & Nephrology Authors: Tuttle KR, Knight R, Appelbaum PS, Arora T, Bansal S, Bebiak J, Brown K, Campbell C, Cooperman L, Corona-Villalobos CP, Dighe A, de Boer IH, Hall DE, Jefferson N, Jolly S, Kermani A, Lee SC, Mehl K, Murugan R, Roberts GV, Rosas SE, Himmelfarb J, Miller RT Tags: Clin J Am Soc Nephrol Source Type: research

Esaxerenone (CS-3150) in Patients with Type 2 Diabetes and Microalbuminuria (ESAX-DN): Phase 3 Randomized Controlled Clinical Trial.
Abstract BACKGROUND AND OBJECTIVES: Diabetic kidney disease is an important complication of type 2 diabetes. In a phase 2b study, adding esaxerenone to renin-angiotensin system inhibitors dose dependently reduced the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and microalbuminuria. This 52-week phase 3 study further investigated the effects of esaxerenone on the urinary albumin-to-creatinine ratio in this patient group. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this multicenter, randomized, double-blind study, patients with type 2 diabetes and a urinary albumin-to-creatinine ratio of 45 to
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 25, 2020 Category: Urology & Nephrology Authors: Ito S, Kashihara N, Shikata K, Nangaku M, Wada T, Okuda Y, Sawanobori T Tags: Clin J Am Soc Nephrol Source Type: research

Higher-Dose Sitagliptin and the Risk of Congestive Heart Failure in Older Adults with CKD.
CONCLUSIONS: The risk of death or congestive heart failure was not higher in older adults with CKD starting sitagliptin at>50 versus ≤50 mg/d. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_11_25_CJN08310520_final.mp3. PMID: 33239410 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 25, 2020 Category: Urology & Nephrology Authors: Muanda FT, Weir MA, Bathini L, Clemens KK, Perkovic V, Sood MM, McArthur E, Sontrop JM, Kim RB, Garg AX Tags: Clin J Am Soc Nephrol Source Type: research

Correction.
Authors: PMID: 33239411 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 25, 2020 Category: Urology & Nephrology Tags: Clin J Am Soc Nephrol Source Type: research

Mineralocorticoid Receptor Antagonists for Diabetic Kidney Disease.
PMID: 33239412 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 25, 2020 Category: Urology & Nephrology Authors: Rossing P Tags: Clin J Am Soc Nephrol Source Type: research

Accountable Care Organizations and Spending for Patients Undergoing Long-Term Dialysis.
CONCLUSIONS: There was a substantial increase in the percentage of long-term dialysis beneficiaries aligned to an Accountable Care Organization from 2012 to 2016. Moreover, in adjusted models, Accountable Care Organization alignment was associated with modest cost savings among long-term dialysis beneficiaries with care by a primary care physician. PMID: 33234541 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 24, 2020 Category: Urology & Nephrology Authors: Bakre S, Hollingsworth JM, Yan PL, Lawton EJ, Hirth RA, Shahinian VB Tags: Clin J Am Soc Nephrol Source Type: research

ACOs and Bending the Cost Curve for Health Care Spending for People with Kidney Failure.
PMID: 33234542 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 24, 2020 Category: Urology & Nephrology Authors: Awan AA, Erickson KF Tags: Clin J Am Soc Nephrol Source Type: research

Effects of Canagliflozin in Patients with Baseline eGFR < 30 ml/min per 1.73 m2: Subgroup Analysis of the Randomized CREDENCE Trial.
Effects of Canagliflozin in Patients with Baseline eGFR
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 19, 2020 Category: Urology & Nephrology Authors: Bakris G, Oshima M, Mahaffey KW, Agarwal R, Cannon CP, Capuano G, Charytan DM, de Zeeuw D, Edwards R, Greene T, Heerspink HJL, Levin A, Neal B, Oh R, Pollock C, Rosenthal N, Wheeler DC, Zhang H, Zinman B, Jardine MJ, Perkovic V Tags: Clin J Am Soc Nephrol Source Type: research

Are SGLT2 Inhibitors Safe and Effective in Advanced Diabetic Kidney Disease?
PMID: 33214159 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 19, 2020 Category: Urology & Nephrology Authors: Zoungas S, Polkinghorne KR Tags: Clin J Am Soc Nephrol Source Type: research

A Longitudinal, 3-Month Serologic Assessment of SARS-CoV-2 Infections in a Belgian Hemodialysis Facility.
PMID: 33208402 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 18, 2020 Category: Urology & Nephrology Authors: Labriola L, Scohy A, Seghers F, Perlot Q, De Greef J, Desmet C, Romain C, Morelle J, Yombi JC, Kabamba B, Rodriguez-Villalobos H, Jadoul M Tags: Clin J Am Soc Nephrol Source Type: research

Urinary Soluble CD163 and Disease Activity in Biopsy-Proven ANCA-Associated Glomerulonephritis.
Abstract BACKGROUND AND OBJECTIVES: ANCA-associated GN is a common cause of rapidly progressive GN, with high relapse rates. The early recognition of an ANCA-associated GN relapse is of importance to prevent loss of kidney function. Urinary soluble CD163 has been identified as a promising marker of active ANCA-associated GN. Previous studies, however, are limited by the lack of histologic data. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We analyzed urinary soluble CD163 in 95 patients with ANCA-associated vasculitis who underwent a kidney biopsy. In total, 125 kidney tissue sections (first kidney biop...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 17, 2020 Category: Urology & Nephrology Authors: Aendekerk JP, Timmermans SAMEG, Busch MH, Potjewijd J, Heeringa P, Damoiseaux JGMC, Reutelingsperger CP, van Paassen P, Limburg Renal Registry Tags: Clin J Am Soc Nephrol Source Type: research

Depression Screening Tools for Patients with Kidney Failure: A Systematic Review.
CONCLUSIONS: There is limited research evaluating the diagnostic accuracy of most screening tools for depression in patients with kidney failure, and existing studies may not be generalizable to US populations. Studies suffer from limitations related to methodology quality and/or reporting. Future research should target widely used, free tools such as the Patient Health Questionnaire 2 and the Patient Health Questionnaire 9. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Systematic Review Registration: PROSPERO CRD42020140227. PMID: 33203736 [PubMed - as supplied by publisher] (Source: Clinical Journal of ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 17, 2020 Category: Urology & Nephrology Authors: Kondo K, Antick JR, Ayers CK, Kansagara D, Chopra P Tags: Clin J Am Soc Nephrol Source Type: research

Acute Kidney Injury in a National Cohort of Hospitalized US Veterans with COVID-19.
Abstract BACKGROUND AND OBJECTIVES: Coronavirus disease 2019 (COVID-19) is associated with higher risk of AKI. We aimed to describe rates and characterize predictors and health outcomes associated with AKI in a national cohort of US veterans hospitalized with COVID-19. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a cohort of 5216 US veterans hospitalized with COVID-19 identified through July 23, 2020, we described changes in serum creatinine and examined predictors of AKI and the associations between AKI, health resource utilization, and death, utilizing logistic regressions. We characterized geograp...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 16, 2020 Category: Urology & Nephrology Authors: Bowe B, Cai M, Xie Y, Gibson AK, Maddukuri G, Al-Aly Z Tags: Clin J Am Soc Nephrol Source Type: research

Contextualizing the FHN Nocturnal Trial a Decade Later: How Nocturnal Home Hemodialysis Is Performed Matters to Outcomes.
PMID: 33184091 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 12, 2020 Category: Urology & Nephrology Authors: Pauly RP, Miller BW Tags: Clin J Am Soc Nephrol Source Type: research

Risk Factors for CKD Progression: Overview of Findings from the CRIC Study.
Abstract The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 11, 2020 Category: Urology & Nephrology Authors: Hannan M, Ansari S, Meza N, Anderson AH, Srivastava A, Waikar S, Charleston J, Weir MR, Taliercio J, Horwitz E, Saunders MR, Wolfrum K, Feldman HI, Lash JP, Ricardo AC, CRIC Study Investigators, Chronic Renal Insufficiency Cohort (CRIC) Study Investigator Tags: Clin J Am Soc Nephrol Source Type: research

Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients.
CONCLUSIONS: In a single-center cohort of kidney, combined kidney-pancreas, and pancreas transplant recipients, exposure to hydrochlorothiazide was associated with a two-fold higher risk of squamous cell carcinoma and no higher risk of basal cell carcinoma. PMID: 33172936 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 10, 2020 Category: Urology & Nephrology Authors: Letellier T, Leborgne F, Kerleau C, Gaultier A, Dantal J, Ville S, Divat Consortium Tags: Clin J Am Soc Nephrol Source Type: research