A Donor Utilization Index to Assess the Utilization and Discard of Deceased Donor Kidneys Perceived as High Risk.
Abstract BACKGROUND AND OBJECTIVES: An increasing number of patients on the waitlist for a kidney transplant indicates a need to effectively utilize as many deceased donor kidneys as possible while ensuring acceptable outcomes. Assessing regional and center-level organ utilization with regards to discard can reveal regional variation in suboptimal deceased donor kidney acceptance patterns stemming from perceptions of risk. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We created a weighted donor utilization index from a logistic regression model using high-risk donor characteristics and discard rates fro...
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 17, 2019 Category: Urology & Nephrology Authors: Brennan C, Husain SA, King KL, Tsapepas D, Ratner LE, Jin Z, Schold JD, Mohan S Tags: Clin J Am Soc Nephrol Source Type: research

Safe and Effective Management of Pain in People with CKD.
PMID: 31604792 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 11, 2019 Category: Urology & Nephrology Authors: Davison SN, Rathwell S Tags: Clin J Am Soc Nephrol Source Type: research

Therapeutic Relowering of Plasma Sodium after Overly Rapid Correction of Hyponatremia: What Is the Evidence?
PMID: 31601554 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 10, 2019 Category: Urology & Nephrology Authors: Rondon-Berrios H Tags: Clin J Am Soc Nephrol Source Type: research

Preserving Kidney Function Instead of Replacing It.
PMID: 31594804 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 8, 2019 Category: Urology & Nephrology Authors: Kliger AS, Brosius FC, Diabetic Kidney Disease Task Force of the American Society of Nephrology Tags: Clin J Am Soc Nephrol Source Type: research

Can Dietary Patterns Modify Risk for CKD?
PMID: 31591254 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 7, 2019 Category: Urology & Nephrology Authors: Hu EA, Rebholz CM Tags: Clin J Am Soc Nephrol Source Type: research

Biomarkers to Predict Progression in IgA Nephropathy.
PMID: 31591255 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 7, 2019 Category: Urology & Nephrology Authors: Cheung CK, Barratt J Tags: Clin J Am Soc Nephrol Source Type: research

Is Hypertension Following Donor Nephrectomy Cause For Elevated Living Donor Kidney Function Concern?
PMID: 31591256 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 7, 2019 Category: Urology & Nephrology Authors: Asch WS Tags: Clin J Am Soc Nephrol Source Type: research

Survival and Kidney Outcomes of Children with an Early Diagnosis of Posterior Urethral Valves.
CONCLUSIONS: Patients in this multicenter cohort with posterior urethral valves had a 5% risk of death, and were most likely to die during their initial hospitalization. Risk of death was higher with a diagnosis of pulmonary hypoplasia. Kidney dysplasia was associated with a higher risk of need for dialysis/transplant. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_10_03_CJN04350419.mp3. PMID: 31582461 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 3, 2019 Category: Urology & Nephrology Authors: Herbst KW, Tomlinson P, Lockwood G, Mosha MH, Wang Z, D'Alessandri-Silva C Tags: Clin J Am Soc Nephrol Source Type: research

Associations of Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated GFR.
CONCLUSIONS: The receipt of prescription opioids was associated with a higher risk of death and hospitalization compared with other pain medications, particularly with higher doses and at lower eGFR. PMID: 31582462 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 3, 2019 Category: Urology & Nephrology Authors: Novick TK, Surapaneni A, Shin JI, Alexander GC, Inker LA, Wright EA, Chang AR, Grams ME Tags: Clin J Am Soc Nephrol Source Type: research

Prophylactic Anticoagulation in Adult Patients with Nephrotic Syndrome.
PMID: 31575616 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 1, 2019 Category: Urology & Nephrology Authors: Gordon-Cappitelli J, Choi MJ Tags: Clin J Am Soc Nephrol Source Type: research

How Does CREDENCE Inform Best Use of SGLT2 Inhibitors in CKD?
PMID: 31575617 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 1, 2019 Category: Urology & Nephrology Authors: Neumiller JJ, Kalyani RR Tags: Clin J Am Soc Nephrol Source Type: research

Personalizing the Kidney Transplant Decision: Who Doesn't Benefit From a Kidney Transplant?
PMID: 31575618 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 1, 2019 Category: Urology & Nephrology Authors: Sawinski D, Foley DP Tags: Clin J Am Soc Nephrol Source Type: research

Foamy Urine: Is This a Sign of Kidney Disease?
PMID: 31575619 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 1, 2019 Category: Urology & Nephrology Authors: Khitan ZJ, Glassock RJ Tags: Clin J Am Soc Nephrol Source Type: research

A Technology Roadmap for Innovative Approaches to Kidney Replacement Therapies: A Catalyst for Change.
Abstract The number of patients dialyzed for ESKD exceeds 500,000 in the United States and more than 2.6 million people worldwide, with the expectation that the worldwide number will double by 2030. The human cost of health and societal financial cost of ESKD is substantial. Dialytic therapy is associated with an unacceptably high morbidity and mortality rate and poor quality of life. Although innovation in many areas of science has been transformative, there has been little innovation in dialysis or alternatives for kidney replacement therapy (KRT) since its introduction approximately 70 years ago. Advances in ki...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 27, 2019 Category: Urology & Nephrology Authors: Bonventre JV, Hurst FP, West M, Wu I, Roy-Chaudhury P, Sheldon M Tags: Clin J Am Soc Nephrol Source Type: research

Correction.
Authors: PMID: 31558483 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 26, 2019 Category: Urology & Nephrology Tags: Clin J Am Soc Nephrol Source Type: research

Persistent Disparities in Preemptive Kidney Transplantation.
PMID: 31558484 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 26, 2019 Category: Urology & Nephrology Authors: Purnell TS, Crews DC Tags: Clin J Am Soc Nephrol Source Type: research

Preoperative Noncoronary Cardiovascular Assessment and Management of Kidney Transplant Candidates.
Abstract The pretransplant risk assessment for patients with ESKD who are undergoing evaluation for kidney transplant is complex and multifaceted. When considering cardiovascular disease in particular, many factors should be considered. Given the increasing incidence of kidney transplantation and the growing body of evidence addressing ESKD-specific cardiovascular risk profiles, there is an important need for a consolidated, evidence-based model that considers the unique cardiovascular challenges that these patients face. Cardiovascular physiology is altered in these patients by abrupt shifts in volume status, alt...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 25, 2019 Category: Urology & Nephrology Authors: Baman JR, Knapper J, Raval Z, Harinstein ME, Friedewald JJ, Maganti K, Cuttica MJ, Abecassis MI, Ali ZA, Gheorghiade M, Flaherty JD Tags: Clin J Am Soc Nephrol Source Type: research

Healthy Dietary Patterns and Incidence of CKD: A Meta-Analysis of Cohort Studies.
This study evaluated the associations between dietary patterns and the incidence of CKD in adults and children. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This systematic review and meta-analysis identified potential studies through a systematic search of MEDLINE, Embase and references from eligible studies from database inception to February 2019. Eligible studies were prospective and retrospective cohort studies including adults and children without CKD, where the primary exposure was dietary patterns. To be eligible, studies had to report on the primary outcome, incidence of CKD (eGFR
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 24, 2019 Category: Urology & Nephrology Authors: Bach KE, Kelly JT, Palmer SC, Khalesi S, Strippoli GFM, Campbell KL Tags: Clin J Am Soc Nephrol Source Type: research

Diet Patterns and Kidney Disease.
PMID: 31551238 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 24, 2019 Category: Urology & Nephrology Authors: Lennon MJ Tags: Clin J Am Soc Nephrol Source Type: research

Serum Phosphate and Microvascular Function in a Population-Based Cohort.
Abstract BACKGROUND AND OBJECTIVES: Higher serum phosphate is associated with cardiovascular events and all-cause mortality. Explanations of this association have focused on large vessel calcification and stiffness. Studies suggest that a higher serum phosphate induces microvascular dysfunction, but relationships in humans with direct measures of microvascular function are lacking. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a cross-sectional analysis of 3189 community-living participants that underwent skin capillaroscopy, laser-Doppler flowmetry, and flicker light-induced retinal vessel ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 20, 2019 Category: Urology & Nephrology Authors: Ginsberg C, Houben AJHM, Malhotra R, Berendschot TTJM, Dagnelie PC, Kooman JP, Webers CA, Stehouwer CDA, Ix JH Tags: Clin J Am Soc Nephrol Source Type: research

Risk Factors for 1-Year Graft Loss After Kidney Transplantation: Systematic Review and Meta-Analysis.
CONCLUSIONS: Recipient age, donor age, standard versus extended criteria donor, living versus deceased donor, HLA mismatch, and delayed graft function all predicted 1-year graft survival. The effect of each risk factor is small. PMID: 31540931 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 20, 2019 Category: Urology & Nephrology Authors: Foroutan F, Friesen EL, Clark KE, Motaghi S, Zyla R, Lee Y, Kamran R, Ali E, De Snoo M, Orchanian-Cheff A, Ribic C, Treleaven DJ, Guyatt G, Meade MO Tags: Clin J Am Soc Nephrol Source Type: research

Self-Reported Incident Hypertension and Long-Term Kidney Function in Living Kidney Donors Compared with Healthy Nondonors.
We examined the association of hypertension with yearly change in eGFR using multilevel linear regression and clustering by participant, with an interaction term for race. RESULTS: Kidney donation was independently associated with a 19% higher risk of hypertension (adjusted hazard ratio, 1.19; 95% confidence interval, 1.01 to 1.41; P=0.04); this association did not vary by race (interaction P=0.60). For white and black nondonors, there was a mean decline in eGFR (-0.4 and -0.3 ml/min per year, respectively) that steepened after incident hypertension (-0.8 and -0.9 ml/min per year, respectively; both P
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 19, 2019 Category: Urology & Nephrology Authors: Holscher CM, Haugen CE, Jackson KR, Garonzik Wang JM, Waldram MM, Bae S, Locke JE, Reed RD, Lentine KL, Gupta G, Weir MR, Friedewald JJ, Verbesey J, Cooper M, Segev DL, Massie AB Tags: Clin J Am Soc Nephrol Source Type: research

Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients.
Abstract BACKGROUND AND OBJECTIVES: In kidney transplant recipients, elevated circulating advanced glycation endproducts (AGEs) are the result of increased formation and decreased kidney clearance. AGEs trigger several intracellular mechanisms that ultimately yield excess cardiovascular disease. We hypothesized that, in stable kidney transplant recipients, circulating AGEs are associated with long-term risk of cardiovascular mortality, and that such a relationship is mediated by inflammatory, oxidative stress, and endothelial dysfunction biomarkers. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospecti...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 17, 2019 Category: Urology & Nephrology Authors: Sotomayor CG, Gomes-Neto AW, van Londen M, Gans ROB, Nolte IM, Berger SP, Navis GJ, Rodrigo R, Leuvenink HGD, Schalkwijk CG, Bakker SJL Tags: Clin J Am Soc Nephrol Source Type: research

Short-Term Effects of Very-Low-Phosphate and Low-Phosphate Diets on Fibroblast Growth Factor 23 in Hemodialysis Patients: A Randomized Crossover Trial.
CONCLUSIONS: Over the 2-day period, the FGF23-lowering effect of the very-low-phosphate diet is similar to that of the low-phosphate diet. The very-low-phosphate diet has an additional phosphate-lowering effect compared with the low-phosphate diet. PMID: 31519550 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 13, 2019 Category: Urology & Nephrology Authors: Tsai WC, Wu HY, Peng YS, Hsu SP, Chiu YL, Yang JY, Chen HY, Pai MF, Lin WY, Hung KY, Chu FY, Tsai SM, Chien KL Tags: Clin J Am Soc Nephrol Source Type: research

Dietary Phosphorus and FGF23: Is More Restriction Better?
PMID: 31519551 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 13, 2019 Category: Urology & Nephrology Authors: Hill Gallant KM Tags: Clin J Am Soc Nephrol Source Type: research

Peritoneal Dialysis Patient Outcomes under the Medicare Expanded Dialysis Prospective Payment System.
Abstract BACKGROUND AND OBJECTIVES: Peritoneal dialysis (PD) use increased in the United States with the introduction of a new Medicare prospective payment system in January 2011 that likely reduced financial disincentives for facility use of this home therapy. The expansion of PD to a broader population and facilities having less PD experience may have implications for patient outcomes. We assessed the impact of PD expansion on PD discontinuation and patient mortality. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A prospective cohort study was conducted of patients treated with PD at 90 days of ESKD. P...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 12, 2019 Category: Urology & Nephrology Authors: Young EW, Kapke A, Ding Z, Baker R, Pearson J, Cogan C, Mukhopadhyay P, Turenne MN Tags: Clin J Am Soc Nephrol Source Type: research

Plasma Galactose-Deficient IgA1 and C3 and CKD Progression in IgA Nephropathy.
CONCLUSIONS: In IgA nephropathy, plasma galactose-deficient IgA1/C3 ratio was associated with CKD progression event independent of clinical and biopsy characteristics. PMID: 31511226 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 11, 2019 Category: Urology & Nephrology Authors: Chen P, Yu G, Zhang X, Xie X, Wang J, Shi S, Liu L, Lv J, Zhang H Tags: Clin J Am Soc Nephrol Source Type: research

Genetic and Environmental Influences on the Correlations between Traits of Metabolic Syndrome and Chronic Kidney Disease.
Abstract BACKGROUND AND OBJECTIVES: Metabolic syndrome is a cluster of risk factors associated with CKD. By studying the genetic and environmental influences on how traits of metabolic syndrome correlate with CKD, the understanding of the etiological relationships can be improved. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: From the population-based TwinGene project within the Swedish Twin Registry, 4721 complete twin pairs (9442 European ancestry participants) were included in this cross-sectional twin study. Metabolic syndrome-related continuous traits were measured, and the binary components as well...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 10, 2019 Category: Urology & Nephrology Authors: Chen X, Bhuiyan I, Kuja-Halkola R, Magnusson PKE, Svensson P Tags: Clin J Am Soc Nephrol Source Type: research

Incidence of ESKD and Mortality among Children with Congenital Heart Disease after Cardiac Surgery.
Abstract BACKGROUND AND OBJECTIVES: Survival after surgical repair for congenital heart disease has markedly improved; however, there are limited data on long-term ESKD and mortality during childhood. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted an observational, population-based cohort study of children who had their first surgery for congenital heart disease within 10 years of birth. The study was conducted in Ontario, Canada, where residents have universal access to health care services. Each child who underwent surgical repair was matched to ten children from the general population who ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 9, 2019 Category: Urology & Nephrology Authors: Parikh CR, Greenberg JH, McArthur E, Thiessen-Philbrook H, Everett AD, Wald R, Zappitelli M, Chanchlani R, Garg AX Tags: Clin J Am Soc Nephrol Source Type: research

CKD in Native Hawaiians and Pacific Islanders: Trouble in Paradise.
PMID: 31501091 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 9, 2019 Category: Urology & Nephrology Authors: Naʻai D, Raphael KL Tags: Clin J Am Soc Nephrol Source Type: research

Real World Data and Evidence: Support for Drug Approval: Applications to Kidney Diseases.
PMID: 31492691 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 6, 2019 Category: Urology & Nephrology Authors: Thompson AM, Southworth MR Tags: Clin J Am Soc Nephrol Source Type: research

Interoperability of Electronic Health Information and Care of Dialysis Patients in the United States.
PMID: 31492692 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 6, 2019 Category: Urology & Nephrology Authors: Sutton PR, Payne TH Tags: Clin J Am Soc Nephrol Source Type: research

An Electronic CKD Phenotype: A Step Forward in Improving Kidney Care.
PMID: 31492804 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 6, 2019 Category: Urology & Nephrology Authors: Tummalapalli SL, Peralta CA Tags: Clin J Am Soc Nephrol Source Type: research

Family Perceptions of Quality of End-of-Life Care for Veterans with Advanced CKD.
CONCLUSIONS: Among patients with advanced CKD, care focused on life extension rather than comfort was associated with lower family ratings of end-of-life care regardless of whether patients had received dialysis. PMID: 31466952 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 29, 2019 Category: Urology & Nephrology Authors: Richards CA, Liu CF, Hebert PL, Ersek M, Wachterman MW, Reinke LF, Taylor LL, O'Hare AM Tags: Clin J Am Soc Nephrol Source Type: research

Kidney Support in Children using an Ultrafiltration Device: A Multicenter, Retrospective Study.
CONCLUSIONS: We report the first pediatric experience using an ultrafiltration device to provide a range of therapies, including CVVH, prolonged intermittent KRT, and slow continuous ultrafiltration. We were able to initiate KRT with minimal complications, particularly in critically ill neonates. There is an unmet need for devices specifically designed for younger patients. Having size-appropriate machines will improve the care of smaller children who require kidney support. PMID: 31462396 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 28, 2019 Category: Urology & Nephrology Authors: Menon S, Broderick J, Munshi R, Dill L, DePaoli B, Fathallah-Shaykh S, Claes D, Goldstein SL, Askenazi DJ Tags: Clin J Am Soc Nephrol Source Type: research

Infection-Related Mortality in Recipients of a Kidney Transplant in Australia and New Zealand: Infection-related mortality in kidney transplant recipients.
In this study the incidence of infectious-related mortality and associated factors were evaluated. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this registry-based retrospective, longitudinal cohort study, recipients of a first kidney transplant in Australia and New Zealand between 1997 and 2015 were included. Cumulative incidence of infectious-related mortality was estimated using competing risk regression (using noninfectious mortality as a competing risk event), and compared with age-matched, populated-based data using standardized incidence ratios. RESULTS: Among 12,519 patients, (median age 46 years...
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 27, 2019 Category: Urology & Nephrology Authors: Chan S, Pascoe EM, Clayton PA, McDonald SP, Lim WH, Sypek MP, Palmer SC, Isbel NM, Francis RS, Campbell SB, Hawley CM, Johnson DW Tags: Clin J Am Soc Nephrol Source Type: research

Pregnancy in a Kidney Transplant Patient.
PMID: 31451514 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 26, 2019 Category: Urology & Nephrology Authors: Ong SC, Kumar V Tags: Clin J Am Soc Nephrol Source Type: research

Correction.
Authors: PMID: 31444173 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 23, 2019 Category: Urology & Nephrology Tags: Clin J Am Soc Nephrol Source Type: research

Secular Trends in Incidence, Modality, and Mortality with Dialysis Receiving AKI in Children in Ontario: A Population-Based Cohort Study.
CONCLUSIONS: In Ontario, the incidence of dialysis-receiving AKI among children has increased between 1996 and 2015. The use of peritoneal dialysis for AKI has declined and the short-term mortality after dialysis-receiving AKI has increased. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_08_23_CJN08250718.mp3. PMID: 31444174 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 23, 2019 Category: Urology & Nephrology Authors: Chanchlani R, Nash DM, McArthur E, Zappitelli M, Archer V, Kuwornu JP, Garg AX, Greenberg JH, Goldstein SL, Thabane L, Wald R Tags: Clin J Am Soc Nephrol Source Type: research

Psychiatric Illness and Mortality in Hospitalized ESKD Dialysis Patients.
CONCLUSIONS: Hospitalizations with psychiatric diagnoses are common in pediatric and adult ESKD patients, and are associated with subsequent higher mortality, compared with hospitalizations without psychiatric diagnoses. The prevalence of hospitalizations with psychiatric diagnoses likely underestimates the burden of mental illness in the population. PMID: 31439538 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 22, 2019 Category: Urology & Nephrology Authors: Kimmel PL, Fwu CW, Abbott KC, Moxey-Mims MM, Mendley S, Norton JM, Eggers PW Tags: Clin J Am Soc Nephrol Source Type: research

Extracorporeal Removal of Poisons and Toxins.
Abstract Extracorporeal therapies have been used to remove toxins from the body for over 50 years and have a greater role than ever before in the treatment of poisonings. Improvements in technology have resulted in increased efficacy of removing drugs and other toxins with hemodialysis, and newer extracorporeal therapy modalities have expanded the role of extracorporeal supportive care of poisoned patients. However, despite these changes, for at least the past three decades the most frequently dialyzed poisons remain salicylates, toxic alcohols, and lithium; in addition, the extracorporeal treatment of choice for ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 22, 2019 Category: Urology & Nephrology Authors: King JD, Kern MH, Jaar BG Tags: Clin J Am Soc Nephrol Source Type: research

Cardiovascular Safety and All-Cause Mortality of Methoxy Polyethylene Glycol-Epoetin Beta and Other Erythropoiesis-Stimulating Agents in Anemia of CKD: A Randomized Noninferiority Trial.
CONCLUSIONS: In patients with anemia of CKD, once-monthly methoxy polyethylene glycol-epoetin beta was noninferior to conventional, shorter-acting erythropoiesis-stimulating agents with respect to rates of major adverse cardiovascular events or all-cause mortality. PMID: 31420350 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 16, 2019 Category: Urology & Nephrology Authors: Locatelli F, Hannedouche T, Fishbane S, Morgan Z, Oguey D, White WB Tags: Clin J Am Soc Nephrol Source Type: research

Methods for Assessing Longitudinal Biomarkers of Time-to-Event Outcomes in CKD: A Simulation Study.
CONCLUSIONS: Different analytic methods resulted in markedly different results. Using the time-invariant average produces inaccurate association estimates, whereas other methods can estimate additive (cumulative average) or instantaneous (LOCF) associations depending on the hypothesized underlying association mechanism and research question. PMID: 31416887 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 15, 2019 Category: Urology & Nephrology Authors: Liu Q, Smith AR, Mariani LH, Nair V, Zee J Tags: Clin J Am Soc Nephrol Source Type: research

Risk of Nephrotic Syndrome for Non-Steroidal Anti-Inflammatory Drug Users.
CONCLUSIONS: The use of conventional NSAIDs was associated with a higher risk of nephrotic syndrome starting from at least 2 weeks of exposure, as well as for recent and past exposure up to 2 years before the diagnosis of nephrotic syndrome. This higher risk appeared mainly attributable to acetic acid and propionic acid derivatives. PMID: 31416888 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 15, 2019 Category: Urology & Nephrology Authors: Bakhriansyah M, Souverein PC, van den Hoogen MWF, de Boer A, Klungel OH Tags: Clin J Am Soc Nephrol Source Type: research

NSAIDs and Nephrotic Syndrome.
aga M PMID: 31416889 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 15, 2019 Category: Urology & Nephrology Authors: Mérida E, Praga M Tags: Clin J Am Soc Nephrol Source Type: research

Combination of Functional Magnetic Resonance Imaging and Histopathologic Analysis to Evaluate Interstitial Fibrosis in Kidney Allografts.
Abstract BACKGROUND AND OBJECTIVES: Recent developments indicated that functional magnetic resonance imaging (MRI) could potentially provide noninvasive assessment of kidney interstitial fibrosis in patients with kidney diseases, but direct evidence from histopathology is scarce. We aimed to explore the diagnostic utilities of functional MRI for the evaluation of kidney allograft interstitial fibrosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We prospectively examined 103 kidney transplant recipients who underwent for-cause biopsies and 20 biopsy-proven normal subjects with functional MRI. Histomorp...
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 15, 2019 Category: Urology & Nephrology Authors: Wang W, Yu Y, Wen J, Zhang M, Chen J, Cheng D, Zhang L, Liu Z Tags: Clin J Am Soc Nephrol Source Type: research

Imaging as a Noninvasive Tool for Evaluating Interstitial Fibrosis in Kidney Allografts.
PMID: 31416891 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 15, 2019 Category: Urology & Nephrology Authors: Poggio ED Tags: Clin J Am Soc Nephrol Source Type: research

The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running.
CONCLUSIONS: All runners experienced a substantial rise in copeptin and body temperature along with salt and water loss due to sweating. Sodium and volume loss via sweat as well as plasma copeptin concentrations were associated with AKI in runners. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_08_13_CJASNPodcast_19_09_.mp3. PMID: 31413064 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 14, 2019 Category: Urology & Nephrology Authors: Mansour SG, Martin TG, Obeid W, Pata RW, Myrick KM, Kukova L, Jia Y, Bjornstad P, El-Khoury JM, Parikh CR Tags: Clin J Am Soc Nephrol Source Type: research

Trends in Disparities in Preemptive Kidney Transplantation in the United States.
Abstract BACKGROUND AND OBJECTIVES: Long wait times for deceased donor kidneys and low rates of preemptive wait-listing have limited preemptive transplantation in the United States. We aimed to assess trends in preemptive deceased donor transplantation with the introduction of the new Kidney Allocation System (KAS) in 2014 and identify whether key disparities in preemptive transplantation have changed. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We identified adult deceased donor kidney transplant recipients in the United States from 2000 to 2018 using the Scientific Registry of Transplant Recipients. ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 14, 2019 Category: Urology & Nephrology Authors: King KL, Husain SA, Jin Z, Brennan C, Mohan S Tags: Clin J Am Soc Nephrol Source Type: research

The Association of Fenofibrate with Kidney Tubular Injury in a Subgroup of Participants in the ACCORD Trial.
PMID: 31409596 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 13, 2019 Category: Urology & Nephrology Authors: Chauhan K, Nadkarni GN, Debnath N, Chan L, Saha A, Garg AX, Parikh CR, Coca SG Tags: Clin J Am Soc Nephrol Source Type: research