Tubular Acidification Defect in Adults with Sickle Cell Disease.
rbebaisse M Abstract BACKGROUND AND OBJECTIVES: Metabolic acidosis is a frequent manifestation of sickle cell disease but the mechanisms and determinants of this disorder are unknown. Our aim was to characterize urinary acidification capacity in adults with sickle cell disease and to identify potential factors associated with decreased capacity to acidify urine. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 25 adults with sickle cell disease and an eGFR of ≥60 ml/min per 1.73 m2 from a single center in France, we performed an acute acidification test after simultaneous administration of furosemi...
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 10, 2019 Category: Urology & Nephrology Authors: Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M Tags: Clin J Am Soc Nephrol Source Type: research

How the Kidney Health Initiative Catalyzes Innovation in a Dynamic Environment.
PMID: 31810991 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 6, 2019 Category: Urology & Nephrology Authors: Harris RC, Cahill Z Tags: Clin J Am Soc Nephrol Source Type: research

Public Policy and Patient Choice of Dialysis Modality.
PMID: 31811083 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 6, 2019 Category: Urology & Nephrology Authors: Hartwell L Tags: Clin J Am Soc Nephrol Source Type: research

Monitoring Complement Activation: The New Conundrum in Thrombotic Microangiopathies.
chi V PMID: 31811084 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 6, 2019 Category: Urology & Nephrology Authors: Fakhouri F, Frémeaux-Bacchi V Tags: Clin J Am Soc Nephrol Source Type: research

Gaps in Care among Veterans with Urinary Stone Disease.
PMID: 31811085 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 6, 2019 Category: Urology & Nephrology Authors: Hsi RS, Hollingsworth JM Tags: Clin J Am Soc Nephrol Source Type: research

Prevention of Bloodstream Infections in Patients Undergoing Hemodialysis.
Abstract Bloodstream infections are an important cause of hospitalizations, morbidity, and mortality in patients receiving hemodialysis. Eliminating bloodstream infections in the hemodialysis setting has been the focus of the Centers for Disease Control and Prevention (CDC) Making Dialysis Safer for Patients Coalition and, more recently, the CDC's partnership with the American Society of Nephrology's Nephrologists Transforming Dialysis Safety Initiative. The majority of vascular access-associated bloodstream infections occur in patients dialyzing with central vein catheters. The CDC's core interventions for bloods...
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 5, 2019 Category: Urology & Nephrology Authors: Fisher M, Golestaneh L, Allon M, Abreo K, Mokrzycki MH Tags: Clin J Am Soc Nephrol Source Type: research

Intravascular Volume Assessment in the Critically Ill Patient.
PMID: 31796424 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 3, 2019 Category: Urology & Nephrology Authors: Vincent JL Tags: Clin J Am Soc Nephrol Source Type: research

Epidemiology of Autosomal Dominant Polycystic Kidney Disease in Olmsted County.
CONCLUSIONS: The point prevalence of definite and likely ADPKD observed in this study is higher than those reported in the literature, but lower than genetic prevalence based on estimates of disease expectancy or on analysis of large population-sequencing databases. PMID: 31791998 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 2, 2019 Category: Urology & Nephrology Authors: Suwabe T, Shukoor S, Chamberlain AM, Killian JM, King BF, Edwards M, Senum SR, Madsen CD, Chebib FT, Hogan MC, Cornec-Le Gall E, Harris PC, Torres VE Tags: Clin J Am Soc Nephrol Source Type: research

Trends in Peritoneal Dialysis Use in the United States after Medicare Payment Reform.
Abstract BACKGROUND AND OBJECTIVES: Peritoneal dialysis (PD) for ESKD is associated with similar mortality, higher quality of life, and lower costs compared with hemodialysis (HD), but has historically been underused. We assessed the effect of the 2011 Medicare prospective payment system (PPS) for dialysis on PD initiation, modality switches, and stable PD use. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using US Renal Data System and Medicare data, we identified all United States patients with ESKD initiating dialysis before (2006-2010) and after (2011-2013) PPS implementation, and observed their moda...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 21, 2019 Category: Urology & Nephrology Authors: Sloan CE, Coffman CJ, Sanders LL, Maciejewski ML, Lee SD, Hirth RA, Wang V Tags: Clin J Am Soc Nephrol Source Type: research

Sodium Glucose Cotransporter 2 Inhibition Heralds a Call-to-Action for Diabetic Kidney Disease.
PMID: 31740570 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 18, 2019 Category: Urology & Nephrology Authors: Tuttle KR, Cherney DZ, Diabetic Kidney Disease Task Force of the American Society of Nephrology Tags: Clin J Am Soc Nephrol Source Type: research

Management of Membranous Nephropathy after MENTOR.
PMID: 31740571 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 18, 2019 Category: Urology & Nephrology Authors: Trivin-Avillach C, Beck LH Tags: Clin J Am Soc Nephrol Source Type: research

Genetic Testing for APOL1 Genetic Variants in Clinical Practice: Finally Starting to Arrive.
PMID: 31740572 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 18, 2019 Category: Urology & Nephrology Authors: Kopp JB, Winkler CA Tags: Clin J Am Soc Nephrol Source Type: research

Peritoneal Dialysis in the Obese Patient.
PMID: 31740573 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 18, 2019 Category: Urology & Nephrology Authors: Kennedy C, Bargman J Tags: Clin J Am Soc Nephrol Source Type: research

Contraception and CKD.
PMID: 31740574 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 18, 2019 Category: Urology & Nephrology Authors: Burgner A, Hladunewich MA Tags: Clin J Am Soc Nephrol Source Type: research

Ambulatory Hemodialysis-Technology Landscape and Potential for Patient-Centered Treatment.
This article explains the motivation for ambulatory hemodialysis and provides an overview of the necessary features of key technologies that will be the basis for new wearable and implantable devices. Early work by pioneers of hemodialysis is described followed by recent experience using a wearable unit on patients. Finally, ongoing efforts to develop an implantable device for kidney replacement and its potential for implantable hemodialysis are presented. PMID: 31727617 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 14, 2019 Category: Urology & Nephrology Authors: Hojs N, Fissell WH, Roy S Tags: Clin J Am Soc Nephrol Source Type: research

Change in Dyslipidemia with Declining Glomerular Filtration Rate and Increasing Proteinuria in Children with CKD.
Abstract BACKGROUND AND OBJECTIVES: Dyslipidemia, a risk factor for cardiovascular disease, is common in CKD but its change over time and how that change is influenced by concurrent progression of CKD have not been previously described. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In the CKD in Children study we prospectively followed children with progressive CKD and utilized multivariable, linear mixed-effects models to quantify the longitudinal relationship between within-subject changes in lipid measures (HDL cholesterol, non-HDL cholesterol, triglycerides) and within-subject changes in GFR, protein...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 11, 2019 Category: Urology & Nephrology Authors: Saland JM, Kupferman JC, Pierce CB, Flynn JT, Mitsnefes MM, Warady BA, Furth SL Tags: Clin J Am Soc Nephrol Source Type: research

Twenty-Four Hour Urine Testing and Prescriptions for Urinary Stone Disease-Related Medications in Veterans.
We examined a national cohort of 130,489 patients with incident urinary stone disease in the Veterans Health Administration between 2007 and 2013 to determine whether prescription patterns for thiazide diuretics, alkali therapy, and allopurinol changed in response to 24-hour urine testing. RESULTS: Stone formers who completed 24-hour urine testing (n=17,303; 13%) were significantly more likely to be prescribed thiazide diuretics, alkali therapy, and allopurinol compared with those who did not complete a 24-hour urine test (n=113,186; 87%). Prescription of thiazide diuretics increased in patients with hypercalciuria (9...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 11, 2019 Category: Urology & Nephrology Authors: Song S, Thomas IC, Ganesan C, Sohlberg EM, Chertow GM, Liao JC, Conti S, Elliott CS, Pao AC, Leppert JT Tags: Clin J Am Soc Nephrol Source Type: research

APOL1 Nephropathy Risk Alleles and Risk of Sepsis in Blacks.
CONCLUSIONS: In community-dwelling black adults, carriage of APOL1 nephropathy risk alleles are common and associated with higher risk of sepsis. PMID: 31704668 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 8, 2019 Category: Urology & Nephrology Authors: Chaudhary NS, Moore JX, Zakai NA, Judd SE, Naik RP, Limou S, Cushman M, Lange LA, Wang HE, Winkler CA, Irvin MR, Kopp JB, Gutiérrez OM Tags: Clin J Am Soc Nephrol Source Type: research

Transforming Care for Patients and Providers: Perspective from Nonprofit Providers.
PMID: 31704669 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 8, 2019 Category: Urology & Nephrology Authors: Watnick S, Silberzweig J Tags: Clin J Am Soc Nephrol Source Type: research

APOL1 Nephropathy Risk Variant Associations with Diseases beyond the Kidney: APOL1 and Sepsis.
PMID: 31704670 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 8, 2019 Category: Urology & Nephrology Authors: Ma L, Freedman BI Tags: Clin J Am Soc Nephrol Source Type: research

Advancing American Kidney Health: Perspective from Fresenius Medical Care.
PMID: 31704671 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 8, 2019 Category: Urology & Nephrology Authors: Kossmann RJ, Weinhandl ED Tags: Clin J Am Soc Nephrol Source Type: research

Advancing American Kidney Health: Perspective from DaVita, Inc.
PMID: 31704672 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 8, 2019 Category: Urology & Nephrology Authors: Nissenson AR, Becker BN Tags: Clin J Am Soc Nephrol Source Type: research

Preparing the Nephrology Workforce for the Transformation to Value-Based Kidney Care: Needs Assessment for Advancing American Kidney Health.
PMID: 31699811 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 7, 2019 Category: Urology & Nephrology Authors: Tummalapalli SL, Peralta CA Tags: Clin J Am Soc Nephrol Source Type: research

A Call to Action for the Kidney Community: Nephrologists' Perspective on Advancing American Kidney Health.
PMID: 31699812 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 7, 2019 Category: Urology & Nephrology Authors: Bieber SD, Gadegbeku CA Tags: Clin J Am Soc Nephrol Source Type: research

July 10, 2019, A Day to Be Remembered: A Patient Perspective.
PMID: 31694862 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 6, 2019 Category: Urology & Nephrology Authors: Scott N Tags: Clin J Am Soc Nephrol Source Type: research

A Patient's Perspective on Advancing American Kidney Health Initiative.
PMID: 31694863 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 6, 2019 Category: Urology & Nephrology Authors: Knight R Tags: Clin J Am Soc Nephrol Source Type: research

Complement Activation and Thrombotic Microangiopathies.
CONCLUSIONS: The proposed methodology identifies complement overactivation in patients with atypical hemolytic uremic syndrome at acute phase and in other diseases such as HELLP syndrome and preeclampsia. Moreover, it is sensitive enough to individually assess the efficiency of the C5 inhibition treatment. PMID: 31694864 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 6, 2019 Category: Urology & Nephrology Authors: Palomo M, Blasco M, Molina P, Lozano M, Praga M, Torramade-Moix S, Martinez-Sanchez J, Cid J, Escolar G, Carreras E, Paules C, Crispi F, Quintana LF, Poch E, Rodas L, Goma E, Morelle J, Espinosa M, Morales E, Avila A, Cabello V, Ariceta G, Chocron S, Manr Tags: Clin J Am Soc Nephrol Source Type: research

A Vision for Advancing American Kidney Health: View from the US Department of Health and Human Services.
PMID: 31690693 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 5, 2019 Category: Urology & Nephrology Authors: Patel S, Boehler A, Uehlecke N Tags: Clin J Am Soc Nephrol Source Type: research

Advancing American Kidney Health: An Introduction.
PMID: 31690694 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 5, 2019 Category: Urology & Nephrology Authors: Mehrotra R Tags: Clin J Am Soc Nephrol Source Type: research

Winning the War on Kidney Disease: Perspective from the American Society of Nephrology.
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_11_05_CJN10180819.mp3. PMID: 31690695 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 5, 2019 Category: Urology & Nephrology Authors: Rosenberg ME, Ibrahim T Tags: Clin J Am Soc Nephrol Source Type: research

Fibrillary Glomerulonephritis: Clinicopathologic Features and Atypical Cases from a Multi-Institutional Cohort.
Abstract BACKGROUND AND OBJECTIVES: Fibrillary GN has been defined as an immune complex-mediated GN with amyloid-like fibrils larger than amyloid which are IgG positive and Congo red negative. With discovery of DNAJB9 as a highly sensitive and specific marker for fibrillary GN, the specificity of the morphologic criteria for establishing the diagnosis of fibrillary GN has come into question. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We sought to (1) determine anatomic characteristics that best define fibrillary GN and (2) identify clinical and pathologic features that predict outcomes. RESULTS: ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 4, 2019 Category: Urology & Nephrology Authors: Andeen NK, Troxell ML, Riazy M, Avasare RS, Lapasia J, Jefferson JA, Akilesh S, Najafian B, Nicosia RF, Alpers CE, Smith KD Tags: Clin J Am Soc Nephrol Source Type: research

Quantifying Donor Effects on Transplant Outcomes Using Kidney Pairs from Deceased Donors.
CONCLUSIONS: Overall results indicated that the donor constitution has small or moderate effect on post-transplant clinical outcomes. PMID: 31676539 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 1, 2019 Category: Urology & Nephrology Authors: Kerr KF, Morenz ER, Thiessen-Philbrook H, Coca SG, Wilson FP, Reese PP, Parikh CR Tags: Clin J Am Soc Nephrol Source Type: research

Varying Association of Extended Hours Dialysis with Quality of Life.
CONCLUSIONS: The effect of extended hours hemodialysis on patient-reported outcome measures reached statistical significance in some but not all measures. Within each measure the effect was consistent across predefined subgroups. The clinical importance of these differences is unclear. PMID: 31672793 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 31, 2019 Category: Urology & Nephrology Authors: Smyth B, van den Broek-Best O, Hong D, Howard K, Rogers K, Zuo L, Gray NA, de Zoysa JR, Chan CT, Lin H, Zhang L, Xu J, Cass A, Gallagher M, Perkovic V, Jardine M Tags: Clin J Am Soc Nephrol Source Type: research

The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors.
Abstract BACKGROUND AND OBJECTIVES: Immune checkpoint inhibitor use in oncology is increasing rapidly. We sought to determine the frequency, severity, cause, and predictors of AKI in a real-world population receiving checkpoint inhibitors. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We included all patients who received checkpoint inhibitor therapy from May 2011 to December 2016 at Massachusetts General Hospital. Baseline serum creatinine, averaged 6 months before checkpoint inhibitor start date, was compared with all subsequent creatinine values within 12 months of starting therapy. AKI was defined by...
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 31, 2019 Category: Urology & Nephrology Authors: Seethapathy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME Tags: Clin J Am Soc Nephrol Source Type: research

AKI with Immune Checkpoint Inhibitors: A Push beyond Case Reports.
PMID: 31672795 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 31, 2019 Category: Urology & Nephrology Authors: Carlos CA, Hsu RK Tags: Clin J Am Soc Nephrol Source Type: research

How Extended Hemodialysis Treatment Time Can Affect Patient Quality of Life.
PMID: 31672796 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 31, 2019 Category: Urology & Nephrology Authors: Wilk AS, Lea JP Tags: Clin J Am Soc Nephrol Source Type: research

Serum Calcification Propensity and Clinical Events in CKD.
CONCLUSIONS: Among patients with CKD stages 2-4, higher serum calcification propensity is associated with atherosclerotic cardiovascular disease events, ESKD, and all-cause mortality, but this association was not independent of kidney function. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_10_28_CJN04710419.mp3. PMID: 31658949 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 28, 2019 Category: Urology & Nephrology Authors: Bundy JD, Cai X, Mehta RC, Scialla JJ, de Boer IH, Hsu CY, Go AS, Dobre MA, Chen J, Rao PS, Leonard MB, Lash JP, Block GA, Townsend RR, Feldman HI, Smith ER, Pasch A, Isakova T, CRIC Study Investigators Tags: Clin J Am Soc Nephrol Source Type: research

Sensitivity and Specificity of Pathologic Findings to Diagnose Lupus Nephritis.
CONCLUSIONS: In conclusion, combinations of pathologic features can distinguish lupus nephritis from nonlupus glomerulopathies with high specificity and varying sensitivity. Even with stringent criteria, however, rare examples of nonlupus glomerulopathies may exhibit characteristic features of lupus nephritis. PMID: 31653670 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 25, 2019 Category: Urology & Nephrology Authors: Kudose S, Santoriello D, Bomback AS, Stokes MB, D'Agati VD, Markowitz GS Tags: Clin J Am Soc Nephrol Source Type: research

Sex Differences in Kidney Replacement Therapy Initiation and Maintenance.
CONCLUSIONS: Since the beginning of KRT programs reporting to the ERA-EDTA Registry since the 1960s, fewer women than men have received KRT. The relative difference between men and women initiating and undergoing KRT has remained consistent over the last five decades and in all studied countries. PMID: 31649071 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 24, 2019 Category: Urology & Nephrology Authors: Antlanger M, Noordzij M, van de Luijtgaarden M, Carrero JJ, Palsson R, Finne P, Hemmelder MH, Aresté-Fosalba N, Reisæter AV, Cases A, Traynor JP, Kramar R, Massy Z, Jager KJ, Hecking M, ERA-EDTA Registry Tags: Clin J Am Soc Nephrol Source Type: research

Sex and the Incidence and Prevalence of Kidney Disease.
PMID: 31649072 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 24, 2019 Category: Urology & Nephrology Authors: Tomlinson LA, Clase CM Tags: Clin J Am Soc Nephrol Source Type: research

Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and Prevention.
Abstract In this review of the application of proteomics and metabolomics to kidney disease research, we review key concepts, highlight illustrative examples, and outline future directions. The proteome and metabolome reflect the influence of environmental exposures in addition to genetic coding. Circulating levels of proteins and metabolites are dynamic and modifiable, and thus amenable to therapeutic targeting. Design and analytic considerations in proteomics and metabolomics studies should be tailored to the investigator's goals. For the identification of clinical biomarkers, adjustment for all potential confou...
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 21, 2019 Category: Urology & Nephrology Authors: Dubin RF, Rhee EP Tags: Clin J Am Soc Nephrol Source Type: research

Alterations of Proximal Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease.
CONCLUSIONS: Patients with ADPKD and preserved and reduced GFR demonstrate lower tubular secretory solute excretion compared with healthy controls and patients with non-ADPKD CKD. Our results suggest that tubular secretion is impaired in ADPKD independent of GFR. PMID: 31628117 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 18, 2019 Category: Urology & Nephrology Authors: Wang K, Zelnick LR, Chen Y, Hoofnagle AN, Watnick T, Seliger S, Kestenbaum B Tags: Clin J Am Soc Nephrol Source Type: research

Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults.
CONCLUSIONS: In community-dwelling older adults with relatively preserved baseline eGFR, a fast eGFR decline is associated with incident frailty. PMID: 31628118 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 18, 2019 Category: Urology & Nephrology Authors: Guerville F, de Souto Barreto P, Taton B, Bourdel-Marchasson I, Rolland Y, Vellas B, Multidomain Alzheimer Preventive Trial (MAPT)/Data Sharing Alzheimer (DSA) Group Tags: Clin J Am Soc Nephrol Source Type: research

Frailty and CKD: Chicken or the Egg?
PMID: 31628119 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 18, 2019 Category: Urology & Nephrology Authors: Delgado C Tags: Clin J Am Soc Nephrol Source Type: research

A Donor Utilization Index to Assess the Utilization and Discard of Deceased Donor Kidneys Perceived as High Risk.
Abstract BACKGROUND AND OBJECTIVES: An increasing number of patients on the waitlist for a kidney transplant indicates a need to effectively utilize as many deceased donor kidneys as possible while ensuring acceptable outcomes. Assessing regional and center-level organ utilization with regards to discard can reveal regional variation in suboptimal deceased donor kidney acceptance patterns stemming from perceptions of risk. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We created a weighted donor utilization index from a logistic regression model using high-risk donor characteristics and discard rates fro...
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 17, 2019 Category: Urology & Nephrology Authors: Brennan C, Husain SA, King KL, Tsapepas D, Ratner LE, Jin Z, Schold JD, Mohan S Tags: Clin J Am Soc Nephrol Source Type: research

Safe and Effective Management of Pain in People with CKD.
PMID: 31604792 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 11, 2019 Category: Urology & Nephrology Authors: Davison SN, Rathwell S Tags: Clin J Am Soc Nephrol Source Type: research

Therapeutic Relowering of Plasma Sodium after Overly Rapid Correction of Hyponatremia: What Is the Evidence?
PMID: 31601554 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 10, 2019 Category: Urology & Nephrology Authors: Rondon-Berrios H Tags: Clin J Am Soc Nephrol Source Type: research

Preserving Kidney Function Instead of Replacing It.
PMID: 31594804 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 8, 2019 Category: Urology & Nephrology Authors: Kliger AS, Brosius FC, Diabetic Kidney Disease Task Force of the American Society of Nephrology Tags: Clin J Am Soc Nephrol Source Type: research

Can Dietary Patterns Modify Risk for CKD?
PMID: 31591254 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 7, 2019 Category: Urology & Nephrology Authors: Hu EA, Rebholz CM Tags: Clin J Am Soc Nephrol Source Type: research

Biomarkers to Predict Progression in IgA Nephropathy.
PMID: 31591255 [PubMed - in process] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 7, 2019 Category: Urology & Nephrology Authors: Cheung CK, Barratt J Tags: Clin J Am Soc Nephrol Source Type: research