Net Endogenous Acid Excretion and Kidney Allograft Outcomes
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.00780121. doi: 10.2215/CJN.00780121. Online ahead of print.ABSTRACTBackground and objectives: High dietary acid load may accelerate kidney function decline. We prospectively investigated whether dietary acid load is associated with graft outcomes in kidney transplant recipients and whether venous bicarbonate (HCO3 -) mediates this association. Design, setting, participants and measurements: We used data from 642 kidney transplant recipients with a functioning graft ≥1 year after transplantation. Net endogenous acid production (NEAP) was estimated using food frequency questionnaires...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Stanley Yeung Antonio Gomes-Neto Maryse Ost é Else van den Berg Jenny Kootstra-Ros Jan-Stephan Sanders Stefan Berger Juan-Jesus Carrero Martin De Borst Gerjan Navis Stephan Bakker Source Type: research

Acute Kidney Injury in the Modern Era of Allogeneic Hematopoietic Stem Cell Transplantation
Conclusions AKI post-hematopoietic cell transplant remains a major concern. Risk of AKI was higher with exposure to CNIs. T cell depleted hematopoietic cell transplants and higher albumin had lower risk of AKI. Forty-three percent of patients requiring KRT recovered kidney function. Prospective studies are needed to further assess modification of these risk factors.PMID:34135023 | DOI:10.2215/CJN.19801220 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Matthew Abramson Victoria Gutgarts Junting Zheng Molly Maloy Josel Ruiz Michael Scordo Edgar Jaimes Insara Jaffer Sathick Source Type: research

Advancing American Kidney Health and the Role of Sodium-Glucose Cotransporter-2 Inhibitors
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.05450421. doi: 10.2215/CJN.05450421. Online ahead of print.NO ABSTRACTPMID:34135024 | DOI:10.2215/CJN.05450421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Jiahua Li Sri Lekha Tummalapalli Mallika Mendu Source Type: research

Kidney Disease among People Who Are Incarcerated
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.01910221. doi: 10.2215/CJN.01910221. Online ahead of print.ABSTRACTChronic kidney disease (CKD) affects 15% of US adults and is associated with increased morbidity and mortality. CKD disproportionately impacts certain populations, including racial and ethnic minorities and individuals from disadvantaged socioeconomic backgrounds. These groups are also disproportionately impacted by incarceration and barriers to accessing health services. Incarceration represents an opportunity to link marginalized individuals to CKD care. Despite a legal obligation to provide a community standard of c...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Matthew Murphy Ann Ding Justin Berk Josiah Rich George Bayliss Source Type: research

Net Endogenous Acid Excretion and Kidney Allograft Outcomes
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.00780121. doi: 10.2215/CJN.00780121. Online ahead of print.ABSTRACTBackground and objectives: High dietary acid load may accelerate kidney function decline. We prospectively investigated whether dietary acid load is associated with graft outcomes in kidney transplant recipients and whether venous bicarbonate (HCO3 -) mediates this association. Design, setting, participants and measurements: We used data from 642 kidney transplant recipients with a functioning graft ≥1 year after transplantation. Net endogenous acid production (NEAP) was estimated using food frequency questionnaires...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Stanley Yeung Antonio Gomes-Neto Maryse Ost é Else van den Berg Jenny Kootstra-Ros Jan-Stephan Sanders Stefan Berger Juan-Jesus Carrero Martin De Borst Gerjan Navis Stephan Bakker Source Type: research

Acute Kidney Injury in the Modern Era of Allogeneic Hematopoietic Stem Cell Transplantation
Conclusions AKI post-hematopoietic cell transplant remains a major concern. Risk of AKI was higher with exposure to CNIs. T cell depleted hematopoietic cell transplants and higher albumin had lower risk of AKI. Forty-three percent of patients requiring KRT recovered kidney function. Prospective studies are needed to further assess modification of these risk factors.PMID:34135023 | DOI:10.2215/CJN.19801220 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Matthew Abramson Victoria Gutgarts Junting Zheng Molly Maloy Josel Ruiz Michael Scordo Edgar Jaimes Insara Jaffer Sathick Source Type: research

Advancing American Kidney Health and the Role of Sodium-Glucose Cotransporter-2 Inhibitors
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.05450421. doi: 10.2215/CJN.05450421. Online ahead of print.NO ABSTRACTPMID:34135024 | DOI:10.2215/CJN.05450421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Jiahua Li Sri Lekha Tummalapalli Mallika Mendu Source Type: research

Kidney Disease among People Who Are Incarcerated
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.01910221. doi: 10.2215/CJN.01910221. Online ahead of print.ABSTRACTChronic kidney disease (CKD) affects 15% of US adults and is associated with increased morbidity and mortality. CKD disproportionately impacts certain populations, including racial and ethnic minorities and individuals from disadvantaged socioeconomic backgrounds. These groups are also disproportionately impacted by incarceration and barriers to accessing health services. Incarceration represents an opportunity to link marginalized individuals to CKD care. Despite a legal obligation to provide a community standard of c...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Matthew Murphy Ann Ding Justin Berk Josiah Rich George Bayliss Source Type: research

Net Endogenous Acid Excretion and Kidney Allograft Outcomes
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.00780121. doi: 10.2215/CJN.00780121. Online ahead of print.ABSTRACTBackground and objectives: High dietary acid load may accelerate kidney function decline. We prospectively investigated whether dietary acid load is associated with graft outcomes in kidney transplant recipients and whether venous bicarbonate (HCO3 -) mediates this association. Design, setting, participants and measurements: We used data from 642 kidney transplant recipients with a functioning graft ≥1 year after transplantation. Net endogenous acid production (NEAP) was estimated using food frequency questionnaires...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Stanley Yeung Antonio Gomes-Neto Maryse Ost é Else van den Berg Jenny Kootstra-Ros Jan-Stephan Sanders Stefan Berger Juan-Jesus Carrero Martin De Borst Gerjan Navis Stephan Bakker Source Type: research

Acute Kidney Injury in the Modern Era of Allogeneic Hematopoietic Stem Cell Transplantation
Conclusions AKI post-hematopoietic cell transplant remains a major concern. Risk of AKI was higher with exposure to CNIs. T cell depleted hematopoietic cell transplants and higher albumin had lower risk of AKI. Forty-three percent of patients requiring KRT recovered kidney function. Prospective studies are needed to further assess modification of these risk factors.PMID:34135023 | DOI:10.2215/CJN.19801220 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Matthew Abramson Victoria Gutgarts Junting Zheng Molly Maloy Josel Ruiz Michael Scordo Edgar Jaimes Insara Jaffer Sathick Source Type: research

Advancing American Kidney Health and the Role of Sodium-Glucose Cotransporter-2 Inhibitors
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.05450421. doi: 10.2215/CJN.05450421. Online ahead of print.NO ABSTRACTPMID:34135024 | DOI:10.2215/CJN.05450421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Jiahua Li Sri Lekha Tummalapalli Mallika Mendu Source Type: research

Kidney Disease among People Who Are Incarcerated
Clin J Am Soc Nephrol. 2021 Jun 16:CJN.01910221. doi: 10.2215/CJN.01910221. Online ahead of print.ABSTRACTChronic kidney disease (CKD) affects 15% of US adults and is associated with increased morbidity and mortality. CKD disproportionately impacts certain populations, including racial and ethnic minorities and individuals from disadvantaged socioeconomic backgrounds. These groups are also disproportionately impacted by incarceration and barriers to accessing health services. Incarceration represents an opportunity to link marginalized individuals to CKD care. Despite a legal obligation to provide a community standard of c...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 17, 2021 Category: Urology & Nephrology Authors: Matthew Murphy Ann Ding Justin Berk Josiah Rich George Bayliss Source Type: research

Black Race Coefficient in GFR Estimation and Prevalence of CKD-Related Complications
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.04430321. doi: 10.2215/CJN.04430321. Online ahead of print.NO ABSTRACTPMID:34127483 | DOI:10.2215/CJN.04430321 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Carl Walther Wolfgang Winkelmayer Sankar Navaneethan Source Type: research

Bone and Mineral Disease in Kidney Transplant Recipients
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.03410321. doi: 10.2215/CJN.03410321. Online ahead of print.ABSTRACTAfter kidney transplantation mineral and bone disorders are associated with higher risk of fractures and consequent morbidity and mortality. Disorders of calcium and phosphorus, vitamin D deficiency and hyperparathyroidism are also common. The epidemiology of bone disease has evolved over the past several decades due to changes in immunosuppressive regimens, mainly glucocorticoid minimization or avoidance. The assessment of bone disease in kidney transplant recipients relies on risk factor recognition and bone mineral ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Pascale Khairallah Thomas Nickolas Source Type: research

Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.04560421. doi: 10.2215/CJN.04560421. Online ahead of print.ABSTRACTDespite evidence of multi-organ tropism of SARS-CoV-2 in patients with COVID-19, direct viral kidney invasion has been difficult to demonstrate. The question of whether SARS-CoV-2 can directly infect the kidney is relevant to the understanding of pathogenesis of acute kidney injury and collapsing glomerulopathy in COVID-19. Methodologies to document SARS-CoV-2 infection that have been used include immunohistochemistry, immunofluorescence, reverse transcriptase polymerase chain reaction (RT-PCR), in situ hybridization a...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Luise Hassler Fabiola Reyes Matthew Sparks Paul Welling Daniel Batlle Source Type: research

Black Race Coefficient in GFR Estimation and Prevalence of CKD-Related Complications
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.04430321. doi: 10.2215/CJN.04430321. Online ahead of print.NO ABSTRACTPMID:34127483 | DOI:10.2215/CJN.04430321 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Carl Walther Wolfgang Winkelmayer Sankar Navaneethan Source Type: research

Bone and Mineral Disease in Kidney Transplant Recipients
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.03410321. doi: 10.2215/CJN.03410321. Online ahead of print.ABSTRACTAfter kidney transplantation mineral and bone disorders are associated with higher risk of fractures and consequent morbidity and mortality. Disorders of calcium and phosphorus, vitamin D deficiency and hyperparathyroidism are also common. The epidemiology of bone disease has evolved over the past several decades due to changes in immunosuppressive regimens, mainly glucocorticoid minimization or avoidance. The assessment of bone disease in kidney transplant recipients relies on risk factor recognition and bone mineral ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Pascale Khairallah Thomas Nickolas Source Type: research

Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.04560421. doi: 10.2215/CJN.04560421. Online ahead of print.ABSTRACTDespite evidence of multi-organ tropism of SARS-CoV-2 in patients with COVID-19, direct viral kidney invasion has been difficult to demonstrate. The question of whether SARS-CoV-2 can directly infect the kidney is relevant to the understanding of pathogenesis of acute kidney injury and collapsing glomerulopathy in COVID-19. Methodologies to document SARS-CoV-2 infection that have been used include immunohistochemistry, immunofluorescence, reverse transcriptase polymerase chain reaction (RT-PCR), in situ hybridization a...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Luise Hassler Fabiola Reyes Matthew Sparks Paul Welling Daniel Batlle Source Type: research

Black Race Coefficient in GFR Estimation and Prevalence of CKD-Related Complications
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.04430321. doi: 10.2215/CJN.04430321. Online ahead of print.NO ABSTRACTPMID:34127483 | DOI:10.2215/CJN.04430321 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Carl Walther Wolfgang Winkelmayer Sankar Navaneethan Source Type: research

Bone and Mineral Disease in Kidney Transplant Recipients
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.03410321. doi: 10.2215/CJN.03410321. Online ahead of print.ABSTRACTAfter kidney transplantation mineral and bone disorders are associated with higher risk of fractures and consequent morbidity and mortality. Disorders of calcium and phosphorus, vitamin D deficiency and hyperparathyroidism are also common. The epidemiology of bone disease has evolved over the past several decades due to changes in immunosuppressive regimens, mainly glucocorticoid minimization or avoidance. The assessment of bone disease in kidney transplant recipients relies on risk factor recognition and bone mineral ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Pascale Khairallah Thomas Nickolas Source Type: research

Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19
Clin J Am Soc Nephrol. 2021 Jun 14:CJN.04560421. doi: 10.2215/CJN.04560421. Online ahead of print.ABSTRACTDespite evidence of multi-organ tropism of SARS-CoV-2 in patients with COVID-19, direct viral kidney invasion has been difficult to demonstrate. The question of whether SARS-CoV-2 can directly infect the kidney is relevant to the understanding of pathogenesis of acute kidney injury and collapsing glomerulopathy in COVID-19. Methodologies to document SARS-CoV-2 infection that have been used include immunohistochemistry, immunofluorescence, reverse transcriptase polymerase chain reaction (RT-PCR), in situ hybridization a...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 15, 2021 Category: Urology & Nephrology Authors: Luise Hassler Fabiola Reyes Matthew Sparks Paul Welling Daniel Batlle Source Type: research

Sincere Integration of Patients' Perspectives into Kidney Care: Affirming and Adopting Patient Activation
Clin J Am Soc Nephrol. 2021 Jun;16(6):840-842. doi: 10.2215/CJN.05050421. Epub 2021 Jun 11.NO ABSTRACTPMID:34117076 | DOI:10.2215/CJN.05050421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Devika Nair Kerri L Cavanaugh Source Type: research

Mineralocorticoid Receptor Antagonists and Cardiovascular Health with Kidney Failure
Clin J Am Soc Nephrol. 2021 Jun;16(6):843-845. doi: 10.2215/CJN.04460421.NO ABSTRACTPMID:34117077 | DOI:10.2215/CJN.04460421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Qandeel H Soomro David M Charytan Source Type: research

Dialyzing Acute Kidney Injury Patients after Hospital Discharge
Clin J Am Soc Nephrol. 2021 Jun;16(6):848-849. doi: 10.2215/CJN.04590421. Epub 2021 Jun 11.NO ABSTRACTPMID:34117078 | DOI:10.2215/CJN.04590421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Ian McCoy Chi-Yuan Hsu Source Type: research

To Add Weight to Overweight
Clin J Am Soc Nephrol. 2021 Jun;16(6):850-852. doi: 10.2215/CJN.04150321.NO ABSTRACTPMID:34117079 | DOI:10.2215/CJN.04150321 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Maatje D A van Gastel Esther Meijer Source Type: research

Severe Acute Kidney Injury and Mortality in Extremely Low Gestational Age Neonates
Clin J Am Soc Nephrol. 2021 Jun;16(6):862-869. doi: 10.2215/CJN.18841220. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: AKI is associated with poor short- and long-term outcomes. Questions remain about the frequency and timing of AKI, and whether AKI is a cause of death in extremely low gestational age neonates.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Recombinant Erythropoietin for Protection of Infant Kidney Disease Study examines the kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo Neuroprotection study, a randomized, placebo-controlled trial of recombinant human e...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Sangeeta Hingorani Robert H Schmicker Patrick D Brophy Patrick J Heagerty Sandra E Juul Stuart L Goldstein David Askenazi PENUT Investigators Source Type: research

Reliability and Validity of the Patient Activation Measure in Kidney Disease: Results of Rasch Analysis
Clin J Am Soc Nephrol. 2021 Jun;16(6):880-888. doi: 10.2215/CJN.19611220. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: Despite the increasing prioritization of the promotion of patient activation in nephrology, its applicability to people with CKD is not well established. Before the Patient Activation Measure is universally adopted for use in CKD, it is important to critically evaluate this measure. The aim of this study was to describe the psychometric properties of the Patient Activation Measure in CKD.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A survey containing the 13-item Patient Activation Measure was...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Courtney J Lightfoot Thomas J Wilkinson Katherine E Memory Jared Palmer Alice C Smith Source Type: research

Overweight and Obesity and Progression of ADPKD
Clin J Am Soc Nephrol. 2021 Jun;16(6):908-915. doi: 10.2215/CJN.16871020. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: On the basis of earlier observations, we evaluated the association between overweight and obesity and rapid progression of autosomal dominant polycystic kidney disease in participants in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO) 3:4 trial. More importantly, we also determined whether efficacy of tolvaptan was attenuated in individuals with baseline overweight or obesity.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Kristen L Nowak Cortney Steele Berenice Gitomer Wenchyi Wang John Ouyang Michel B Chonchol Source Type: research

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis
Clin J Am Soc Nephrol. 2021 Jun;16(6):916-925. doi: 10.2215/CJN.15841020. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: Patients with kidney failure have a high risk of cardiovascular disease due to cardiac remodeling, left ventricular fibrosis, and hyperaldosteronism, all of which can be potentially mitigated by mineralocorticoid receptor antagonists. However, because of the fear of hyperkalemia, the use of mineralocorticoid receptor antagonists in patients with kidney failure is limited in current clinical practice, and few studies have investigated the efficacy and safety. Thus, we aimed to determine the benefits ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Kuan-Ting Chen Yi-No Kang Yen-Chung Lin I-Lin Tsai Wei-Chiao Chang Te-Chao Fang Mai-Szu Wu Chih-Chin Kao Source Type: research

Vaccines and Disease Relapses in Children with Nephrotic Syndrome
Clin J Am Soc Nephrol. 2021 Jun;16(6):937-938. doi: 10.2215/CJN.01890221. Epub 2021 Jun 11.NO ABSTRACTPMID:34117084 | DOI:10.2215/CJN.01890221 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Andrea Angeletti Maurizio Bruschi Silvia Bianchin Irene Bonato Carolina Montobbio Enrico Verrina Francesca Lugani Paolo Cravedi Gian Marco Ghiggeri Source Type: research

Sincere Integration of Patients' Perspectives into Kidney Care: Affirming and Adopting Patient Activation
Clin J Am Soc Nephrol. 2021 Jun;16(6):840-842. doi: 10.2215/CJN.05050421. Epub 2021 Jun 11.NO ABSTRACTPMID:34117076 | DOI:10.2215/CJN.05050421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Devika Nair Kerri L Cavanaugh Source Type: research

Mineralocorticoid Receptor Antagonists and Cardiovascular Health with Kidney Failure
Clin J Am Soc Nephrol. 2021 Jun;16(6):843-845. doi: 10.2215/CJN.04460421.NO ABSTRACTPMID:34117077 | DOI:10.2215/CJN.04460421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Qandeel H Soomro David M Charytan Source Type: research

Dialyzing Acute Kidney Injury Patients after Hospital Discharge
Clin J Am Soc Nephrol. 2021 Jun;16(6):848-849. doi: 10.2215/CJN.04590421. Epub 2021 Jun 11.NO ABSTRACTPMID:34117078 | DOI:10.2215/CJN.04590421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Ian McCoy Chi-Yuan Hsu Source Type: research

To Add Weight to Overweight
Clin J Am Soc Nephrol. 2021 Jun;16(6):850-852. doi: 10.2215/CJN.04150321.NO ABSTRACTPMID:34117079 | DOI:10.2215/CJN.04150321 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Maatje D A van Gastel Esther Meijer Source Type: research

Severe Acute Kidney Injury and Mortality in Extremely Low Gestational Age Neonates
Clin J Am Soc Nephrol. 2021 Jun;16(6):862-869. doi: 10.2215/CJN.18841220. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: AKI is associated with poor short- and long-term outcomes. Questions remain about the frequency and timing of AKI, and whether AKI is a cause of death in extremely low gestational age neonates.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Recombinant Erythropoietin for Protection of Infant Kidney Disease Study examines the kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo Neuroprotection study, a randomized, placebo-controlled trial of recombinant human e...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Sangeeta Hingorani Robert H Schmicker Patrick D Brophy Patrick J Heagerty Sandra E Juul Stuart L Goldstein David Askenazi PENUT Investigators Source Type: research

Reliability and Validity of the Patient Activation Measure in Kidney Disease: Results of Rasch Analysis
Clin J Am Soc Nephrol. 2021 Jun;16(6):880-888. doi: 10.2215/CJN.19611220. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: Despite the increasing prioritization of the promotion of patient activation in nephrology, its applicability to people with CKD is not well established. Before the Patient Activation Measure is universally adopted for use in CKD, it is important to critically evaluate this measure. The aim of this study was to describe the psychometric properties of the Patient Activation Measure in CKD.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A survey containing the 13-item Patient Activation Measure was...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Courtney J Lightfoot Thomas J Wilkinson Katherine E Memory Jared Palmer Alice C Smith Source Type: research

Overweight and Obesity and Progression of ADPKD
Clin J Am Soc Nephrol. 2021 Jun;16(6):908-915. doi: 10.2215/CJN.16871020. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: On the basis of earlier observations, we evaluated the association between overweight and obesity and rapid progression of autosomal dominant polycystic kidney disease in participants in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO) 3:4 trial. More importantly, we also determined whether efficacy of tolvaptan was attenuated in individuals with baseline overweight or obesity.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Kristen L Nowak Cortney Steele Berenice Gitomer Wenchyi Wang John Ouyang Michel B Chonchol Source Type: research

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis
Clin J Am Soc Nephrol. 2021 Jun;16(6):916-925. doi: 10.2215/CJN.15841020. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: Patients with kidney failure have a high risk of cardiovascular disease due to cardiac remodeling, left ventricular fibrosis, and hyperaldosteronism, all of which can be potentially mitigated by mineralocorticoid receptor antagonists. However, because of the fear of hyperkalemia, the use of mineralocorticoid receptor antagonists in patients with kidney failure is limited in current clinical practice, and few studies have investigated the efficacy and safety. Thus, we aimed to determine the benefits ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Kuan-Ting Chen Yi-No Kang Yen-Chung Lin I-Lin Tsai Wei-Chiao Chang Te-Chao Fang Mai-Szu Wu Chih-Chin Kao Source Type: research

Vaccines and Disease Relapses in Children with Nephrotic Syndrome
Clin J Am Soc Nephrol. 2021 Jun;16(6):937-938. doi: 10.2215/CJN.01890221. Epub 2021 Jun 11.NO ABSTRACTPMID:34117084 | DOI:10.2215/CJN.01890221 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Andrea Angeletti Maurizio Bruschi Silvia Bianchin Irene Bonato Carolina Montobbio Enrico Verrina Francesca Lugani Paolo Cravedi Gian Marco Ghiggeri Source Type: research

Sincere Integration of Patients' Perspectives into Kidney Care: Affirming and Adopting Patient Activation
Clin J Am Soc Nephrol. 2021 Jun;16(6):840-842. doi: 10.2215/CJN.05050421. Epub 2021 Jun 11.NO ABSTRACTPMID:34117076 | DOI:10.2215/CJN.05050421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Devika Nair Kerri L Cavanaugh Source Type: research

Mineralocorticoid Receptor Antagonists and Cardiovascular Health with Kidney Failure
Clin J Am Soc Nephrol. 2021 Jun;16(6):843-845. doi: 10.2215/CJN.04460421.NO ABSTRACTPMID:34117077 | DOI:10.2215/CJN.04460421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Qandeel H Soomro David M Charytan Source Type: research

Dialyzing Acute Kidney Injury Patients after Hospital Discharge
Clin J Am Soc Nephrol. 2021 Jun;16(6):848-849. doi: 10.2215/CJN.04590421. Epub 2021 Jun 11.NO ABSTRACTPMID:34117078 | DOI:10.2215/CJN.04590421 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Ian McCoy Chi-Yuan Hsu Source Type: research

To Add Weight to Overweight
Clin J Am Soc Nephrol. 2021 Jun;16(6):850-852. doi: 10.2215/CJN.04150321.NO ABSTRACTPMID:34117079 | DOI:10.2215/CJN.04150321 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Maatje D A van Gastel Esther Meijer Source Type: research

Severe Acute Kidney Injury and Mortality in Extremely Low Gestational Age Neonates
Clin J Am Soc Nephrol. 2021 Jun;16(6):862-869. doi: 10.2215/CJN.18841220. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: AKI is associated with poor short- and long-term outcomes. Questions remain about the frequency and timing of AKI, and whether AKI is a cause of death in extremely low gestational age neonates.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Recombinant Erythropoietin for Protection of Infant Kidney Disease Study examines the kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo Neuroprotection study, a randomized, placebo-controlled trial of recombinant human e...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Sangeeta Hingorani Robert H Schmicker Patrick D Brophy Patrick J Heagerty Sandra E Juul Stuart L Goldstein David Askenazi PENUT Investigators Source Type: research

Reliability and Validity of the Patient Activation Measure in Kidney Disease: Results of Rasch Analysis
Clin J Am Soc Nephrol. 2021 Jun;16(6):880-888. doi: 10.2215/CJN.19611220. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: Despite the increasing prioritization of the promotion of patient activation in nephrology, its applicability to people with CKD is not well established. Before the Patient Activation Measure is universally adopted for use in CKD, it is important to critically evaluate this measure. The aim of this study was to describe the psychometric properties of the Patient Activation Measure in CKD.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A survey containing the 13-item Patient Activation Measure was...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Courtney J Lightfoot Thomas J Wilkinson Katherine E Memory Jared Palmer Alice C Smith Source Type: research

Overweight and Obesity and Progression of ADPKD
Clin J Am Soc Nephrol. 2021 Jun;16(6):908-915. doi: 10.2215/CJN.16871020. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: On the basis of earlier observations, we evaluated the association between overweight and obesity and rapid progression of autosomal dominant polycystic kidney disease in participants in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO) 3:4 trial. More importantly, we also determined whether efficacy of tolvaptan was attenuated in individuals with baseline overweight or obesity.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Kristen L Nowak Cortney Steele Berenice Gitomer Wenchyi Wang John Ouyang Michel B Chonchol Source Type: research

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis
Clin J Am Soc Nephrol. 2021 Jun;16(6):916-925. doi: 10.2215/CJN.15841020. Epub 2021 Jun 11.ABSTRACTBACKGROUND AND OBJECTIVES: Patients with kidney failure have a high risk of cardiovascular disease due to cardiac remodeling, left ventricular fibrosis, and hyperaldosteronism, all of which can be potentially mitigated by mineralocorticoid receptor antagonists. However, because of the fear of hyperkalemia, the use of mineralocorticoid receptor antagonists in patients with kidney failure is limited in current clinical practice, and few studies have investigated the efficacy and safety. Thus, we aimed to determine the benefits ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Kuan-Ting Chen Yi-No Kang Yen-Chung Lin I-Lin Tsai Wei-Chiao Chang Te-Chao Fang Mai-Szu Wu Chih-Chin Kao Source Type: research

Vaccines and Disease Relapses in Children with Nephrotic Syndrome
Clin J Am Soc Nephrol. 2021 Jun;16(6):937-938. doi: 10.2215/CJN.01890221. Epub 2021 Jun 11.NO ABSTRACTPMID:34117084 | DOI:10.2215/CJN.01890221 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 12, 2021 Category: Urology & Nephrology Authors: Andrea Angeletti Maurizio Bruschi Silvia Bianchin Irene Bonato Carolina Montobbio Enrico Verrina Francesca Lugani Paolo Cravedi Gian Marco Ghiggeri Source Type: research

Transforming the Care of Patients with Diabetic Kidney Disease
Clin J Am Soc Nephrol. 2021 Jun 8:CJN.18641120. doi: 10.2215/CJN.18641120. Online ahead of print.ABSTRACTDiabetes and its associated complications pose an immediate threat to humankind. Diabetic kidney disease (DKD) is one of the most devastating complications, increasing the risk of death more than 10-fold over that in the general population [1]. Until very recently, the only drugs proven and recommended to slow progression of DKD were angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor blockers (ARBs), which act by inhibiting the renin-angiotensin system (RAS) [2]. Despite their efficacy as ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 9, 2021 Category: Urology & Nephrology Authors: Frank Brosius Iii David Cherney Patrick Gee Raymond Harris Alan Kliger Katherine Tuttle Susan Quaggin Source Type: research

Transforming the Care of Patients with Diabetic Kidney Disease
Clin J Am Soc Nephrol. 2021 Jun 8:CJN.18641120. doi: 10.2215/CJN.18641120. Online ahead of print.ABSTRACTDiabetes and its associated complications pose an immediate threat to humankind. Diabetic kidney disease (DKD) is one of the most devastating complications, increasing the risk of death more than 10-fold over that in the general population [1]. Until very recently, the only drugs proven and recommended to slow progression of DKD were angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor blockers (ARBs), which act by inhibiting the renin-angiotensin system (RAS) [2]. Despite their efficacy as ...
Source: Clinical Journal of the American Society of Nephrology : CJASN - June 9, 2021 Category: Urology & Nephrology Authors: Frank Brosius Iii David Cherney Patrick Gee Raymond Harris Alan Kliger Katherine Tuttle Susan Quaggin Source Type: research