Gliflozins in the Treatment of Non-diabetic Experimental Cardiovascular Diseases
Physiol Res. 2024 Apr 18. Online ahead of print.ABSTRACTA new class of antidiabetic drugs - gliflozins (inhibitors of sodium glucose cotransporter-2; SGLT-2i) stimulate glucose and sodium excretion, thereby contributing to improved glycemic control, weight loss and blood pressure reduction in diabetic patients. Large clinical trials in patients with type 2 diabetes treated with empagliflozin, canagliflozin or dapagliflozin have demonstrated their excellent efficacy in improving many cardiovascular outcomes, including the reduction of death from cardiovascular diseases, non-fatal myocardial infarction or stroke, and hospita...
Source: Physiological Research - April 18, 2024 Category: Physiology Authors: I Van ěčková J Zicha Source Type: research
Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation
In conclusion, our findings suggest that ASM in podocytes plays a crucial role in the control of NLRP3 inflammasome activation and exosome release.PMID:38634138 | DOI:10.1152/ajprenal.00195.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Dandan Huang Jason M Kidd Yao Zou Xiaoyuan Wu Ningjun Li Todd W B Gehr Pin-Lan Li Guangbi Li Source Type: research
Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation
In conclusion, our findings suggest that ASM in podocytes plays a crucial role in the control of NLRP3 inflammasome activation and exosome release.PMID:38634138 | DOI:10.1152/ajprenal.00195.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Dandan Huang Jason M Kidd Yao Zou Xiaoyuan Wu Ningjun Li Todd W B Gehr Pin-Lan Li Guangbi Li Source Type: research
Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation
In conclusion, our findings suggest that ASM in podocytes plays a crucial role in the control of NLRP3 inflammasome activation and exosome release.PMID:38634138 | DOI:10.1152/ajprenal.00195.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Dandan Huang Jason M Kidd Yao Zou Xiaoyuan Wu Ningjun Li Todd W B Gehr Pin-Lan Li Guangbi Li Source Type: research
Phosphatidic Acid Promoting the Generation of Interleukin ‐17A Producing Double‐Negative T Cells by Enhancing mTORC1 Signaling in Lupus
ConclusionThe accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2024 Category: Rheumatology Authors: Wenjing Li,
Xiaojun Tang,
Yuanyuan Zheng,
Xuefeng Xu,
Nan Zhao,
Betty P. Tsao,
Xuebing Feng,
Lingyun Sun Tags: Full Length Source Type: research
Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria. Oxidative stress is closely associated with the wo... (Source: Cell Division)
Source: Cell Division - April 17, 2024 Category: Cytology Authors: Baomei Xu, Fang Cheng and Xiaolei Xue Tags: Research Source Type: research
Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional magnetic resonance imaging
Conclusion: The degree of renal oxygenation reduction is correlated with the severity of renal injury in CKD. SSR can improve renal hypoxia to attenuate renal injury in 5/6 (A/I) rats of CKD.PMID:38622926 | DOI:10.1080/0886022X.2024.2338565 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Yizeng Xu Fang Lu Meng Wang Lingchen Wang Chaoyang Ye Shuohui Yang Chen Wang Source Type: research
Phosphatidic Acid Promoting the Generation of Interleukin ‐17A Producing Double‐Negative T Cells by Enhancing mTORC1 Signaling in Lupus
ConclusionThe accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 16, 2024 Category: Rheumatology Authors: Wenjing Li,
Xiaojun Tang,
Yuanyuan Zheng,
Xuefeng Xu,
Nan Zhao,
Betty P. Tsao,
Xuebing Feng,
Lingyun Sun Tags: Full Length Source Type: research
Extracellular mitochondrial components as new biomarkers for lupus nephritis
This study has evaluated extracellular mitochondrial components, including cell-free mitochondria, and cell-free mitochondrial DNA as probable biomarkers of the degree of nephritis. Both showed a significant correlation with proteinuria and protein-creatinine ratio. Our study substantiates their usage as clinical biomarkers of nephritis upon their validation in a larger cohort of lupus nephritis patients and other forms of nephritis. Although the current data suggest using cell-free mitochondria as a biomarker of lupus nephritis is better than the cell-free mitochondrial DNA.PMID:38621786 | DOI:10.1177/09612033241247622 (Source: Lupus)
Source: Lupus - April 15, 2024 Category: Rheumatology Authors: Sharath Gowda Khushboo Rana Ankit Kumar Pradip Kumar Prajapati Namisha Patel Sapan Pandya Ratika Srivastava Source Type: research
Atypical anti-glomerular basement membrane disease with membranous hyperplasia: diagnostic challenges and treatment variability
This case report presents a detailed analysis of a 31-year-old male patient who presented with a complex array of clinical symptoms, including proteinuria, hematuria, edema, and kidney insufficiency. Despite u... (Source: BMC Nephrology)
Source: BMC Nephrology - April 15, 2024 Category: Urology & Nephrology Authors: Ruoyu Tong, Zhengmao Luo, Xianyang Zhong, Liming Fan, Huangwen Lai, Meng Shen and Yuanhang Huang Tags: Case Report Source Type: research
Effect of proteinuria at relapse on shear wave velocity assessed using ultrasound elastography in children with idiopathic nephrotic syndrome
ConclusionsSWV decreased in the presence of severe proteinuria at relapse compared to the remission measurements. Although more cases need to be studied, the decrease in SWV may reflect the mechanism by which protein leaks into the urine, not just a direct change caused by the presence of proteinuria. (Source: Journal of Medical Ultrasonics)
Source: Journal of Medical Ultrasonics - April 13, 2024 Category: Radiology Source Type: research
Porto-sinusoidal vascular disorder and nephrotic-range proteinuria due to venous vasculitis in Beh çet's disease
We report a case of an Iranian male that presented with porto-sinusoidal vascular disorder due to venous vasculitis as initial manifestation of BD. Despite immunosuppression and anticoagulation, he subsequently developed severe nephrotic-range proteinuria that mimicked a primary renal disease but was completely and immediately ameliorated by stenting of the vena cava. This demonstrates that the proteinuria was caused by increased intraglomerular pressure due to venous outflow obstruction as a consequence of venous vasculitis. To our knowledge, this is the first report of massive proteinuria caused by venous obstruction of ...
Source: Clinical Immunology - April 12, 2024 Category: Allergy & Immunology Authors: M E Annink T B van der Houwen J J T H Roelofs R B Takkenberg J A M van Laar N C van der Weerd A E Hak A J Kwakernaak Source Type: research
Porto-sinusoidal vascular disorder and nephrotic-range proteinuria due to venous vasculitis in Beh çet's disease
We report a case of an Iranian male that presented with porto-sinusoidal vascular disorder due to venous vasculitis as initial manifestation of BD. Despite immunosuppression and anticoagulation, he subsequently developed severe nephrotic-range proteinuria that mimicked a primary renal disease but was completely and immediately ameliorated by stenting of the vena cava. This demonstrates that the proteinuria was caused by increased intraglomerular pressure due to venous outflow obstruction as a consequence of venous vasculitis. To our knowledge, this is the first report of massive proteinuria caused by venous obstruction of ...
Source: Clinical Immunology - April 12, 2024 Category: Allergy & Immunology Authors: M E Annink T B van der Houwen J J T H Roelofs R B Takkenberg J A M van Laar N C van der Weerd A E Hak A J Kwakernaak Source Type: research
The key role of altered tubule cell lipid metabolism in kidney disease development
Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent studies have also highlighted the role of increased de novo lipogenesis in kidney fibrosis. The defect in fatty acid oxidation will cause energy starvation. (Source: Kidney International)
Source: Kidney International - April 10, 2024 Category: Urology & Nephrology Authors: Lauren E. Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak Tags: review Source Type: research
