Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation

In conclusion, our findings suggest that ASM in podocytes plays a crucial role in the control of NLRP3 inflammasome activation and exosome release.PMID:38634138 | DOI:10.1152/ajprenal.00195.2023

Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Dandan Huang Jason M Kidd Yao Zou Xiaoyuan Wu Ningjun Li Todd W B Gehr Pin-Lan Li Guangbi Li Source Type: research