Giant cell arteritis with positive temporal artery biopsy but without ultrasound halo sign
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 18, 2022 Category: Rheumatology Authors: Takeshi Suzuki, Sumiyo Ando, Miho Ohshima, Akitake Suzuki Tags: Clinical Image Source Type: research

Potential residual confounders in an analysis of lifestyle factors and risk of incident systemic lupus erythematosus: comment on the article by Choi et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 14, 2022 Category: Rheumatology Authors: Pei ‐En Kao, Amy Ker, Cheng‐Ruei Yang, James Cheng‐Chung Wei Tags: LETTERS Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 14, 2022 Category: Rheumatology Authors: Sharon A. Chung, Philip Seo, Peter A. Merkel, Carol A. Langford Tags: LETTER Source Type: research

Vascular monosodium urate crystal deposition in gout: a dual ‐energy CT and microscopy study of cadaveric donors
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 13, 2022 Category: Rheumatology Authors: Nicola Dalbeth, Mariam Alhilali, Peter Riordan, Ravi Narang, Ashika Chhana, Sue McGlashan, Anthony Doyle, Mariano Andres Tags: Letters Source Type: research

Clinical Images: Extranodal natural killer/T cell lymphoma as a rare mimicker of granulomatosis with polyangiitis
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 13, 2022 Category: Rheumatology Authors: Jennifer Strouse, Anand Rajan, He B. Chang, Mohamad D. Dimachkie, Christopher Halbur, Brittany Bettendorf Tags: Clinical Image Source Type: research

Association of a Combination of Healthy Lifestyle Behaviors With Reduced Risk of Incident Systemic Lupus Erythematosus
ConclusionThese results indicate that the risk of developing SLE, a disease in which significant evidence of genetic involvement has been established, might be reduced by nearly 50% with adherence to modifiable healthy lifestyle behaviors. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 12, 2022 Category: Rheumatology Authors: May Y. Choi, Jill Hahn, Susan Malspeis, Emma F. Stevens, Elizabeth W. Karlson, Jeffrey A. Sparks, Kazuki Yoshida, Laura Kubzansky, Karen H. Costenbader Tags: Full Length Source Type: research

Rheumatoid factor and anti ‐modified protein antibody reactivities converge on IgG epitopes
ConclusionThe repertoire of epitopes bound by AMPAs includes modified IgG epitopes, positioning IgG as a common antigen that connects the otherwise divergent reactivities of RFs and AMPAs. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 10, 2022 Category: Rheumatology Authors: Aisha M. Mergaert, Zihao Zheng, Michael F. Denny, Maya F. Amjadi, S. Janna Bashar, Michael A. Newton, Vivianne Malmstr öm, Caroline Grönwall, Sara S. McCoy, Miriam A. Shelef Tags: Full Length Source Type: research

Multiple variants of soluble CD146 are involved in Systemic Sclerosis: identification of a novel pro ‐fibrotic factor
ConclusionVariants of sCD146, and in particular the novel I5-13-sCD146 splice variant, could thus constitute novel biomarkers and/or molecular targets for the diagnosis and treatment of SSc, but also of other angiogenesis- or fibrosis-related pathologies. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 10, 2022 Category: Rheumatology Authors: Marie Nollet, Richard Bachelier, Ahmad Joshkon, Wa ël Traboulsi, Amandine Mahieux, Anais Moyon, Alexandre Muller, Indumathi Somasundaram, Stéphanie Simoncini, Franck Peiretti, Aurélie S. Leroyer, Benjamin Guillet, Brigitte Granel, Françoi Tags: Full Length Source Type: research

Semaphorin3B plays a central role in serum ‐induced arthritis model and is reduced in patients with rheumatoid arthritis
ConclusionsSema3B expression has a protective role in a mouse model of arthritis. In RA patients, expression levels depend on the disease stage, suggesting different regulatory roles in disease onset and progression. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 9, 2022 Category: Rheumatology Authors: Ana Igea, Tiago Carvalheiro, Beatriz Malvar ‐Fernández, Sara Martinez‐Ramos, Carlos Rafael‐Vidal, Ellis Niemantsverdriet, Jezabel Varadé, Andrea Fernández‐Carrera, Norman Jimenez, Trudy McGarry, Angela Rodriguez‐Trillo, Douglas Vea Tags: Full Length Source Type: research

No added value of duloxetine for patients with chronic pain due to hip or knee osteoarthritis: a cluster randomised trial
ConclusionsNo effect was found of duloxetine added to usual care compared to usual care alone in patients with chronic OA pain. For patients with symptoms of centralized pain our results need to be confirmed in another trial. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 8, 2022 Category: Rheumatology Authors: Jacoline J. Driest, Dieuwke Schiphof, Aafke R. Koffeman, Marc A. Koopmanschap, Patrick J.E. Bindels, Sita M.A. Bierma ‐Zeinstra Tags: Full Length Source Type: research

Safety and tolerability of the COVID ‐19 messenger RNA vaccine in adolescents with juvenile idiopathic arthritis treated with tumor necrosis factor inhibitors
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 5, 2022 Category: Rheumatology Authors: Dimitra Dimopoulou, Nikos Spyridis, George Vartzelis, Maria N. Tsolia, Despoina N. Maritsi Tags: Letters Source Type: research

Association of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis, With Obesity ‐Related Osteoarthritis
ObjectiveTo test the hypothesis that an altered gut microbiota (dysbiosis) plays a role in obesity-associated osteoarthritis (OA).MethodsStool and blood samples were collected from 92 participants with a body mass index (BMI) ≥30 kg/m2, recruited from the Johnston County Osteoarthritis Project. OA patients (n  = 50) had hand and knee OA (Kellgren/Lawrence [K/L] grade ≥2 or arthroplasty). Controls (n = 42) had no hand OA and a K/L grade of 0–1 for the knees. Compositional analysis of stool samples was carried out by 16S ribosomal RNA amplicon sequencing. Alpha- and beta-diversi...
Source: Arthritis and Rheumatology - January 5, 2022 Category: Rheumatology Authors: Richard F. Loeser, Liubov Arbeeva, Kathryn Kelley, Anthony A. Fodor, Shan Sun, Veronica Ulici, Lara Longobardi, Yang Cui, Delisha A. Stewart, Susan J. Sumner, M. Andrea Azcarate ‐Peril, R. Balfour Sartor, Ian M. Carroll, Jordan B. Renner, Tags: Full Length Source Type: research

Association of Structural Entheseal Lesions With an Increased Risk of Progression From Psoriasis to Psoriatic Arthritis
ConclusionThe presence of structural entheseal lesions as well as low cortical vBMD at entheseal segments are associated with an increased risk of developing PsA in patients with psoriasis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 31, 2021 Category: Rheumatology Authors: David Simon, Koray Tascilar, Arnd Kleyer, Sara Bayat, Eleni Kampylafka, Maria V. Sokolova, Ana Zekovic, Axel J. Hueber, J ürgen Rech, Louis Schuster, Klaus Engel, Michael Sticherling, Georg Schett Tags: Full Length Source Type: research

Progression of Knee Osteoarthritis With Use of Intraarticular Glucocorticoids Versus Hyaluronic Acid
ConclusionIntraarticular GC injections are not associated with an increased risk of knee OA progression compared to HA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 31, 2021 Category: Rheumatology Authors: Justin Bucci, Xiaoyang Chen, Michael LaValley, Michael Nevitt, James Torner, Cora E. Lewis, David T. Felson Tags: Brief Report Source Type: research

Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study
ConclusionMepolizumab at both 100 mg every 4  weeks and 300 mg every 4 weeks is effective for the treatment of EGPA. The 2 doses should be compared in the setting of a controlled trial. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 31, 2021 Category: Rheumatology Authors: Alessandra Bettiol, Maria Letizia Urban, Lorenzo Dagna, Vincent Cottin, Franco Franceschini, Stefano Del Giacco, Franco Schiavon, Thomas Neumann, Giuseppe Lopalco, Pavel Novikov, Chiara Baldini, Carlo Lombardi, Alvise Berti, Federico Alberici Tags: Full Length Source Type: research

Activation of Hypothalamic AMP ‐Activated Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis
ConclusionOverall, these data indicate that EA promotes a central catabolic state that can be targeted and reversed by the activation of hypothalamic AMPK. This might provide new therapeutic alternatives to treat rheumatoid arthritis (RA) –associated metabolic comorbidities, improving the overall prognosis in patients with RA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 30, 2021 Category: Rheumatology Authors: Patricia Seoane ‐Collazo, Eva Rial‐Pensado, Ánxela Estévez‐Salguero, Edward Milbank, Lucía García‐Caballero, Marcos Ríos, Laura Liñares‐Pose, Morena Scotece, Rosalía Gallego, José Manuel Fernández‐Real, Rubén Nogueiras, Ca Tags: Full Length Source Type: research

Long ‐term extension study of tofacitinib in refractory dermatomyositis
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 29, 2021 Category: Rheumatology Authors: Julie J. Paik, Matthew Shneyderman, Laura Gutierrez ‐Alamillo, Jemima Albayda, Eleni Tiniakou, Jamie Perin, Grazyna Purwin, Sherry Leung, Doris Leung, Livia Casciola‐Rosen, Andrew S. Koenig, Lisa Christopher‐Stine Tags: Letter Source Type: research

Evaluation of Immune Response and Disease Status in Systemic Lupus Erythematosus Patients Following SARS –CoV‐2 Vaccination
ObjectiveTo evaluate seroreactivity and disease flares after COVID-19 vaccination in a multiethnic/multiracial cohort of patients with systemic lupus erythematosus (SLE).MethodsNinety SLE patients and 20 healthy controls receiving a complete COVID-19 vaccine regimen were included. IgG seroreactivity to the SARS –CoV-2 spike receptor-binding domain (RBD) and SARS–CoV-2 microneutralization were used to evaluate B cell responses; interferon-γ (IFNγ) production was measured by enzyme-linked immunospot (ELISpot) assay in order to assess T cell responses. Disease activity was measured by the hybrid SLE Di...
Source: Arthritis and Rheumatology - December 29, 2021 Category: Rheumatology Authors: Peter M. Izmirly, Mimi Y. Kim, Marie Samanovic, Ruth Fernandez ‐Ruiz, Sharon Ohana, Kristina K. Deonaraine, Alexis J. Engel, Mala Masson, Xianhong Xie, Amber R. Cornelius, Ramin S. Herati, Rebecca H. Haberman, Jose U. Scher, Allison Guttman Tags: Full Length Source Type: research

Clinical Images: Diffuse systemic sclerosis, skin bleaching, and telangiectasia
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 29, 2021 Category: Rheumatology Authors: Cindy Flower Tags: Clinical Image Source Type: research

Interleukin ‐1‐β‐Activated Microvascular Endothelial Cells Promote DC‐SIGN+ Alternative Macrophages Associated with Skin Fibrosis in Systemic Sclerosis
ConclusionOur work sheds new light on the vicious circle implicating IL-1 β unabated secretion, microvascular endothelial cells activation and generation of DC-SIGN+ AAM in fibrosis during scleroderma. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 28, 2021 Category: Rheumatology Authors: Pa ôline Laurent, Joelle Lapoirie, Damien Leleu, Emeline Levionnois, Cyrielle Grenier, Blanca Jurado‐Mestre, Estibaliz Lazaro, Pierre Duffau, Christophe Richez, Julien Seneschal, Jean‐Luc Pellegrin, Joel Constans, Thierry Schaeverbeke, I Tags: Full Length Source Type: research

B cell numbers predict humoral and cellular response upon SARS ‐CoV‐2 vaccination among patients treated with rituximab
ConclusionsIn patients receiving RTX, a minimum of 10 B cells/ μl in the peripheral circulation candidates as biomarker for a high likelihood of an appropriate cellular and humoral response after SARS-CoV-2 vaccination. Mechanistically, the data emphasize the crucial role of co-stimulatory B cell functions for the proper induction of CD4 responses propagating vaccine-specific B and plasma cell differentiation. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 28, 2021 Category: Rheumatology Authors: Ana L. Stefanski, Hector Rincon ‐Arevalo, Eva Schrezenmeier, Kirsten Karberg, Franziska Szelinski, Jacob Ritter, Bernd Jahrsdörfer, Hubert Schrezenmeier, Carolin Ludwig, Arne Sattler, Katja Kotsch, Yidan Chen, Anne Claußnitzer, Hildrun Ha Tags: Full Length Source Type: research

Rituximab impairs B ‐cell response but not T‐cell response to COVID‐19 vaccine in auto‐immune diseases
ConclusionRTX induced diminished antibody response to mRNA COVD-19 vaccine, but the functional T-cell response was not altered compared to HC and AID patients treated with other IS. Further work is needed to assess the clinical protection granted by a functionally active T-cell response in the absence of an anti-spike antibody response. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 28, 2021 Category: Rheumatology Authors: Samuel Bitoun, Julien Henry, Delphine Desjardins, Christelle Vauloup ‐Fellous, Nicolas Dib, Rakiba Belkhir, Lina Mouna, Candie Joly, Marie Bitu, Bineta Ly, Juliette Pascaud, Raphaèle Seror, Anne‐Marie Roque Afonso, Roger Le Grand, Xavie Tags: Full Length Source Type: research

Conflicting reports of anti ‐NT5C1a autoantibodies in juvenile myositis: Comment on the article by Rietveld et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 28, 2021 Category: Rheumatology Authors: Andrew L. Mammen, Iago Pinal ‐Fernandez, Lisa G. Rider Tags: Letter to the Editor Source Type: research

Fanning the flames of autoimmunity: the microbiome in rheumatic disease
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 28, 2021 Category: Rheumatology Authors: Renuka R. Nayak Tags: Editorial Source Type: research

Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti –Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti–Tumor Necrosis Factor on B Cells
ConclusionOverall, our results support the notion that peripheral blood B cell subsets are remarkably stable in RA and not differentially impacted by dual blockade of TNF and LT with etanercept or single blockade of TNF with adalimumab. Activated B cells do associate with a less robust response. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 28, 2021 Category: Rheumatology Authors: Nida Meednu, Jennifer Barnard, Kelly Callahan, Andreea Coca, Bethany Marston, Ralf Thiele, Darren Tabechian, Marcy Bolster, Jeffrey Curtis, Meggan Mackay, Jonathan Graf, Richard Keating, Edwin Smith, Karen Boyle, Lynette Keyes ‐Elstein, B Tags: Full Length Source Type: research

VEXAS syndrome with systemic lupus erythematosus: expanding the spectrum of associated conditions
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 28, 2021 Category: Rheumatology Authors: Aman Sharma, Gsrsnk Naidu, Prateek Deo, David B. Beck Tags: Letters Source Type: research

Issue Information ‐ General Info
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 27, 2021 Category: Rheumatology Tags: Issue Information ‐ General Info Source Type: research

Clinical Connections
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 27, 2021 Category: Rheumatology Tags: Clinical Connections Source Type: research

In This Issue
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 27, 2021 Category: Rheumatology Tags: In This Issue Source Type: research

Issue Information
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 27, 2021 Category: Rheumatology Tags: Issue Information Source Type: research

Journal Club
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 27, 2021 Category: Rheumatology Tags: Journal Club Source Type: research

Platelet Phagocytosis via P ‐selectin Glycoprotein Ligand 1 and Accumulation of Microparticles in Systemic Sclerosis
ConclusionThe clearance of activated platelets via PSGL-1 limits the undesirable effects of MP-elicited neutrophil activation. This balance is disrupted in patients with SSc. Its reconstitution might curb vascular inflammation and prevent fibrosis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 24, 2021 Category: Rheumatology Authors: Angelo A. Manfredi, Giuseppe A. Ramirez, Cosmo Godino, Annalisa Capobianco, Antonella Monno, Stefano Franchini, Enrico Tombetti, Sara Corradetti, J örg H. W. Distler, Marco E. Bianchi, Patrizia Rovere‐Querini, Norma Maugeri Tags: Full Length Source Type: research

Impact of cytokine inhibitor therapy on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS ‐CoV‐2 in an unvaccinated cohort
Objective: To investigate the impact of biological DMARD treatment on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS-CoV-2 in IMID patients.MethodsAnti-SARS-CoV-2 IgG antibodies were measured in a prospective cohort of healthcare and non-healthcare controls and IMID patients receiving no treatment or treated with conventional or biological DMARDs during the first and second COVID-19 waves. Regression models adjusting for age, sex, sampling-time and exposure risk behavior were used for calculating relative risks of seropositivity. Seroconversion rates were assessed in participa...
Source: Arthritis and Rheumatology - December 24, 2021 Category: Rheumatology Authors: David Simon, Koray Tascilar, Arnd Kleyer, Filippo Fagni, Gerhard Kr önke, Christine Meder, Peter Dietrich, Till Orlemann, Thorsten Kliem, Johanna Mößner, Anna‐Maria Liphardt, Verena Schönau, Daniela Bohr, Louis Schuster, Fabian Hartman Tags: Brief Report Source Type: research

Clinical Images: The appearance of scurvy on magnetic resonance imaging
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 22, 2021 Category: Rheumatology Authors: Sami Giryes, Daniela Militianu, Yolanda Braun ‐Moscovici Tags: Clinical Image Source Type: research

Incidence of Psoriatic Arthritis Among Patients Receiving Biologic Treatments for Psoriasis: A Nested Case –Control Study
ConclusionOur findings show a statistically and clinically significant decreased risk for developing PsA among patients with psoriasis who receive biologic treatments. The results suggest that biologic medications should be considered for patients who present with significant risk factors for PsA at an earlier stage of treatment. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 22, 2021 Category: Rheumatology Authors: Yael Shalev Rosenthal, Naama Schwartz, Iftach Sagy, Lev Pavlovsky Tags: Full Length Source Type: research

Extramucosal formation and prognostic value of secretory antibodies in rheumatoid arthritis
ObjectiveTo investigate levels and possible extramucosal formation of secretory immunoglobulins, including anti-citrullinated protein antibodies (ACPA), in rheumatoid arthritis (RA).MethodsThree patient groups were studied: i) ACPA-positive patients with musculoskeletal pain without clinical arthritis, ii) recent-onset RA, and iii) established RA. In baseline serum (i and ii) and paired synovial fluid samples (iii), we analyzed total secretory IgA (TSIgA), total secretory IgM (TSIgM), free secretory component (SC), and SC ACPA. Extramucosal formation of SC ACPA was investigated by pre-incubating RA sera and affinity-purifi...
Source: Arthritis and Rheumatology - December 20, 2021 Category: Rheumatology Authors: Klara Martinsson, Lovisa Lyttbacka Kling, Karin Roos Ljungberg, Irina Griazeva, Marina Samoylovich, Stephane Paul, Johan R önnelid, Tomas Weitoft, Jonas Wetterö, Alf Kastbom Tags: Full Length Source Type: research

The Contribution of the Interleukin ‐4‐Induced Epithelial Cell Senescence to Glandular Fibrosis in IgG4‐Related Sialadenitis
ConclusionThe cellular senescence induced by IL-4 through the ROS-p38 MAPK-p16INK4A pathway promoted fibrogenesis during IgG4-RS. Our data suggest that cellular senescence could serve as a novel therapeutic target for treating IgG4-RS. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 20, 2021 Category: Rheumatology Authors: Sai ‐Nan Min, Meng‐Qi Zhu, Xiang‐Di Mao, Wei Li, Tai Wei, Mei Mei, Yan Zhang, Li‐Ling Wu, Guang‐Yan Yu, Xin Cong Tags: Full Length Source Type: research

Extensive Bone Marrow Capillary Network Masquerades as Fungal Hyphae in a Patient with Systemic Lupus Erythematosus
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 20, 2021 Category: Rheumatology Authors: Dominic Seet, Shir Ying Lee, Jiacai Cho, Melissa Ooi, Ju Ee Seet, Anselm Mak Tags: Letter to the Editor Source Type: research

Diastolic Dysfunction in Systemic Sclerosis: Risk Factors and Impact on Mortality
ConclusionDD is independently associated with an increased risk of mortality in patients with SSc. Potentially modifiable risk factors, including CAD and obesity, should be addressed in patients with SSc to reduce mortality risk. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 20, 2021 Category: Rheumatology Authors: Alicia M. Hinze, Jamie Perin, Adrianne Woods, Laura K. Hummers, Fredrick M. Wigley, Monica Mukherjee, Ami A. Shah Tags: Full Length Source Type: research

Intensive serum urate lowering with oral urate ‐lowering therapy for erosive gout: A randomized double‐blind controlled trial
ObjectiveTo determine whether intensive serum urate lowering results in improved bone erosion scores in erosive gout.MethodsTwo-year, double-blind, randomized, controlled trial of 104 participants with erosive gout on oral urate-lowering therapy (ULT) and serum urate ≥ 0.30mmol/L was undertaken. Participants were randomly assigned to serum urate target
Source: Arthritis and Rheumatology - December 20, 2021 Category: Rheumatology Authors: Nicola Dalbeth, Anthony J Doyle, Karen Billington, Greg D Gamble, Paul Tan, Kieran Latto, Thrishila Parshu Ram, Ravi Narang, Rachel Murdoch, David Bursill, Borislav Mihov, Lisa K Stamp, Anne Horne Tags: Full Length Source Type: research

Long ‐term risk of cancer development among anti‐Th/To antibody–positive systemic sclerosis patients: comment on the article by Mecoli et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 17, 2021 Category: Rheumatology Authors: Yuta Yamashita, Yoshinao Muro, Haruka Koizumi, Takuya Takeichi, Yasuhiko Yamano, Yasuhiro Kondoh, Masashi Akiyama Tags: LETTERS Source Type: research

Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice
This study was undertaken to assess the influence of the ciliary protein intraflagellar transport protein 88 (IFT88) on postnatal cartilage from mice with conditional knockout of theIft88 gene (Ift88-KO).MethodsIft88fl/fl andaggrecanCreERT2 mice were crossed to create a strain of cartilage-specificIft88-KO mice (aggrecanCreERT2;Ift88fl/fl). In theseIft88-KO mice andIft88fl/fl control mice, tibial articular cartilage thickness was assessed by histomorphometry, and the integrity of the cartilage was assessed using Osteoarthritis Research Society International (OARSI) damage scores, from adolescence through adulthood. In situ...
Source: Arthritis and Rheumatology - December 16, 2021 Category: Rheumatology Authors: Clarissa R. Coveney, Linyi Zhu, Jadwiga Miotla ‐Zarebska, Bryony Stott, Ida Parisi, Vicky Batchelor, Claudia Duarte, Emer Chang, Eleanor McSorley, Tonia L. Vincent, Angus K. T. Wann Tags: Full Length Source Type: research

Effect of Clonally Expanded PD ‐1highCXCR5–CD4+ Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis
ConclusionClonally expanded CD4+ Tph cells accumulate in the joints of ANA-positive JIA patients and, in particular, promote CD21low/ –CD11c+  DN B cell differentiation. The expansion of Tph cells and DN B cells might reflect the autoimmune response in the joints of ANA-positive JIA patients. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 16, 2021 Category: Rheumatology Authors: Jonas Fischer, Johannes Dirks, Julia Klaussner, Gabriele Haase, Annette Holl ‐Wieden, Christine Hofmann, Stephan Hackenberg, Hermann Girschick, Henner Morbach Tags: Full Length Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 15, 2021 Category: Rheumatology Authors: Alan N. Baer, Katherine M. Hammitt Tags: Letters Source Type: research

CD163+ M2 macrophages promote fibrosis in IgG4 ‐related disease via TLR7/IRAK4/NF‐κB signaling
ConclusionCD163+ M2 macrophages promote fibrosis in IgG4-RD by increasing the production of fibrotic cytokines via TLR7/IRAK4/NF- κB signaling.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 15, 2021 Category: Rheumatology Authors: Akira Chinju, Masafumi Moriyama, Noriko Kakizoe ‐Ishiguro, Hu Chen, Yuka Miyahara, A.S.M. Rafiul Haque, Katsuhiro Furusho, Mizuki Sakamoto, Kazuki Kai, Kotono Kibe, Sachiko Hatakeyama‐Furukawa, Miho Ito‐Ohta, Takashi Maehara, Seiji Naka Tags: Full Length Source Type: research

B ‐cell reconstitution is strongly associated with COVID‐19 vaccine responsiveness in rheumatic disease patients treated with rituximab
ObjectiveWe assessed the association of detectable antibody response to COVID-19 vaccination with factors including B-cell depletion in rituximab treated patients.MethodsA retrospective chart review of rituximab treated adult patients who completed mRNA vaccination for SARS-CoV-2 was conducted. Primary outcome was presence and strength of serologic antibody response to vaccination. Comparisons between those with and without detectable serologic response were calculated using T-tests, Fisher's exact test and Wilcoxon rank sum tests. Negative and positive predictive value was calculated between serologic response and B-cell ...
Source: Arthritis and Rheumatology - December 15, 2021 Category: Rheumatology Authors: Sarah Jinich, Kaitlin Schultz, Deanna Jannat ‐Khah, Robert Spiera Tags: Brief Report Source Type: research

Sj ögren disease, not Sjögren's: comment on the article by Baer and Hammitt
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 15, 2021 Category: Rheumatology Authors: Vincent Cottin Tags: Letters Source Type: research

Highly multiplexed imaging mass cytometry identifies similarities between antisynthetase syndrome and dermatomyositis skin lesions
ObjectiveAntisynthetase syndrome (AS) and Dermatomyositis (DM) are autoimmune disorders that overlap clinically. Given the presence of DM skin lesions in AS patients, there is debate about whether AS is distinct or a subclassification of DM. Recently studies identified differences in type I interferon (IFN) between AS and DM muscle and finger eruptions. The aim of this study is to elucidate cutaneous disease pathogenic similarities and differences on a single cell level.MethodsFive AS and seven DM patients were recruited from a prospectively collected database of well-characterized DM patients. AS patients were clinically ...
Source: Arthritis and Rheumatology - December 14, 2021 Category: Rheumatology Authors: Jay Patel, Adarsh Ravishankar, Spandana Maddukuri, Thomas Vazquez, Madison Grinnell, Victoria P. Werth Tags: Full Length Source Type: research

Response to Editorial Accompanying STOP ‐JIA Articles by Ruperto, et al.
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 14, 2021 Category: Rheumatology Authors: Yukiko Kimura, Mei ‐Sing Ong, George Tomlinson, Sarah Ringold, Laura E. Schanberg, Brian M. Feldman, Anne Dennos, Vincent Del Gaizo, Katherine L. Murphy, Mary Ellen Riordan, Marc Natter Tags: Letter to the Editor Source Type: research

Reply to the Letter to the Editor by Kimura et al “Response to Editorial Accompanying STOP‐JIA Articles by Ruperto, et al”
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - December 14, 2021 Category: Rheumatology Authors: Nicolino Ruperto, Alberto Martini, Angela Pistorio, for the Paediatric Rheumatology International Trials Organisation Tags: Reply Source Type: research