Association of a Type 2 –Polarized T Cell Phenotype With Methotrexate Nonresponse in Patients With Rheumatoid Arthritis
This study utilized comprehensive T cel l immunophenotyping to identify specific immunologic pathways associated with MTX ‐nonresponsive joint inflammation in patients with RA .MethodsIn total, 32 patients with recent ‐onset RA were treated with MTX therapy. After 6 months, 15 patients were categorized as responders and 17 as nonresponders. Comprehensive blood T cell immunophenotyping, using multiparameter immunofluorescence flow cytometry analyses, was performed at baseline and following 6 months of treatmen t.ResultsBaseline measures of disease activity (Disease Activity Score in 28 joints [DAS 28], C ‐reactive pro...
Source: Arthritis and Rheumatology - May 29, 2020 Category: Rheumatology Authors: Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Anik ó Malik, Ian D. Haidl, Jean S. Marshall, Thomas B. Issekutz Tags: Original Article Source Type: research

Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool For Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis
This study was undertaken to 1) identify inflammation/endothelial dysfunction–related biomarker profiles reflecting disease severity at diagnosis, and 2) establish whether such biomarker profiles could be used for predicting the response to treatment in patients with juve nile DM .MethodsIn total, 39 biomarkers related to activation of endothelial cells, endothelial dysfunction, and inflammation were measured using multiplex technology in serum samples from treatment ‐naive patients with juvenile DM from 2 independent cohorts (n = 30 and n = 29). Data were analyzed by unsupervised hierarchical clustering, nonparame...
Source: Arthritis and Rheumatology - May 29, 2020 Category: Rheumatology Authors: Judith Wienke, Lauren M. Pachman, Gabrielle A. Morgan, Joo Guan Yeo, Maria C. Amoruso, Victoria Hans, Sylvia S. M. Kamphuis, Esther P. A. H. Hoppenreijs, Wineke Armbrust, J. Merlijn Berg, Petra C. E. Hissink Muller, Kyra A. Gelderman, Thaschaw Tags: Original Article Source Type: research

Reply
Arthritis& Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 28, 2020 Category: Rheumatology Authors: Md Yuzaiful Md Yusof, Edward M Vital, Paul Emery, Sinisa Savic Tags: Letters Source Type: research

Increased awareness of hypogammaglobulinemia after B cell –targeted therapy: comment on the article by Md Yusof et al
Arthritis& Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 28, 2020 Category: Rheumatology Authors: Mohammed Yousuf Karim Tags: Letters Source Type: research

Reply
Arthritis& Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 28, 2020 Category: Rheumatology Authors: Philip J. Mease, David H. Collier, Gregory Kricorian, James B. Chung Tags: Letters Source Type: research

Association of Visceral Adiposity With Pain but Not Structural Osteoarthritis
ConclusionOur findings indicate that visceral fat is associated with an increased risk of musculoskeletal and widespread pain. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 28, 2020 Category: Rheumatology Authors: Shanshan Li, Ann V. Schwartz, Michael P. Lavalley, Na Wang, Nancy Desai, Xianbang Sun, Tuhina Neogi, Michael Nevitt, Cora E. Lewis, Ali Guermazi, Frank Roemer, Neil Segal, David Felson, for the Multicenter Osteoarthritis Study Group Tags: Original Article Source Type: research

Author's Institutional Affiliation Incorrect in the Letter by Liu et al (Arthritis Rheumatol, April 2020)
Arthritis& Rheumatology, Volume 72, Issue 6, Page 1035-1035, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Tags: Errata Source Type: research

Author's Institutional Affiliation Omitted in the Article by Aeschlimann et al (Arthritis Rheumatol, February 2019)
Arthritis& Rheumatology, Volume 72, Issue 6, Page 1035-1035, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Tags: Errata Source Type: research

Issue Information
Arthritis& Rheumatology, Volume 72, Issue 6, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Tags: Issue Information Source Type: research

Clinical Connections
Arthritis& Rheumatology, Volume 72, Issue 6, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Tags: Clinical Connections Source Type: research

In This Issue
Arthritis& Rheumatology, Volume 72, Issue 6, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Tags: In This Issue Source Type: research

In Memoriam: William Phelps Arend, MD, 1937 –2020
Arthritis& Rheumatology, Volume 72, Issue 6, Page 866-867, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Authors: V. Michael Holers, Gary S. Firestein, Kevin D. Deane Tags: In Memoriam Source Type: research

Underscoring the Importance of Allopurinol in Treating Gout: Results of a Food and Drug Administration –Mandated Safety Trial
Arthritis& Rheumatology, Volume 72, Issue 6, Page 877-878, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Authors: Nikolay P. Nikolov, Sally Seymour, Rosemarie Neuner, Ya ‐Hui Hsueh, Eugenio Andraca‐Carrera, Kusum Mistry Tags: Notes from the Field Source Type: research

In Appreciation of Richard J. Bucala, MD, PhD, Editor, Arthritis & Rheumatology, 2015 –2020
Arthritis& Rheumatology, Volume 72, Issue 6, Page 865-865, June 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Authors: Shervin Assassi, Jane S. Diamond Tags: Special Source Type: research

Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3 ‐Driven Inflammation and Gouty Arthritis
This study was undertaken to identify small molecules that directly bind to NLRP 3 in order to develop pharmacologic interventions for NLRP 3 ‐related diseases.MethodsA structure ‐based virtual screening analysis was performed with ~62,800 compounds to select efficient NLRP 3 inhibitors. The production of caspase 1‐p10 and interleukin‐1β (IL ‐1β) was measured by immunoblotting and enzyme‐linked immunosorbent assay to examine NLRP 3 inflammasome activation. Two go uty arthritis models and an air pouch inflammation model induced by monosodium urate monohydrate (MSU ) crystal injection were used for in v...
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Authors: Gabsik Yang, Hye E. Lee, Su ‐Jin Moon, Kyung M. Ko, Jung H. Koh, Jin K. Seok, Jun‐Ki Min, Tae‐Hwe Heo, Han C. Kang, Yong‐Yeon Cho, Hye S. Lee, Katherine A. Fitzgerald, Joo Y. Lee Tags: Original Article Source Type: research

Clinical Images: Giant calcinosis in dermatomyositis and scleroderma overlap
Arthritis& Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Authors: Andreu Fern ández‐Codina, Maria Camprodon‐Gómez, Janet E. Pope Tags: Clinical Image Source Type: research

Is methotrexate as efficacious as etanercept in psoriatic arthritis patients? Comment on the article by Mease et al
Arthritis& Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Authors: Andreas Kerschbaumer, Josef S. Smolen, Daniel Aletaha Tags: Letters Source Type: research

Clinical Images: Acute bilateral pseudogout of the temporomandibular joint
Arthritis& Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 27, 2020 Category: Rheumatology Authors: Maximilian F. Konig, Garrey T. Faller Tags: Clinical Images Source Type: research

Mild course of Coronavirus disease 2019 and spontaneous severe acute respiratory syndrome coronavirus 2 clearance in a patient with depleted peripheral blood B ‐cells due to treatment with rituximab
AbstractOver 4 million cases of Coronavirus disease 2019 (COVID ‐19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) have been confirmed worldwide. Up to 20% of cases develop severe disease and the fatality rate are high.[1] Little is known however on the course of the infection in immunosuppressed patients. We therefore re port the case of a patient with COVID‐19 under immunosuppression with rituximab. This 77‐year‐old woman was admitted to the hospital with a 5‐week history of unclear fever (up to 38.5°C), hypotension (80 mmHg systolic on self‐measurement), occasional ...
Source: Arthritis and Rheumatology - May 26, 2020 Category: Rheumatology Authors: Benedict Fallet, Diego Kyburz, Ulrich A. Walker Tags: LETTER TO THE EDITOR Source Type: research

Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice
ObjectiveTo investigate the effects of a young systemic environment and growth differentiation factor 11 (GDF ‐11) on aging cartilage.MethodsA heterochronic parabiosis model (2 ‐month‐old mouse and 12‐month‐old mouse [Y/O]), an isochronic parabiosis model (12‐month‐old mouse and 12‐month‐old mouse [O/O]), and 12‐month‐old mice alone (O) were evaluated. Knee joints and chondrocytes from old mice were examined by radiography, histology, cell proliferation assays, immunohistochemistry, Western blotting, and quantitative reverse transcriptase–polymerase chain reaction 16 weeks after parabiosis surge...
Source: Arthritis and Rheumatology - May 21, 2020 Category: Rheumatology Authors: Lu Li, Xiaochun Wei, Dongming Wang, Zhi Lv, Xiang Geng, Pengcui Li, Jiangong Lu, Kaihang Wang, Xiaohu Wang, Jian Sun, Xiaoming Cao, Lei Wei Tags: Original Article Source Type: research

Lorecivivint, a Novel Intra ‐articular CLK/DYRK1A Inhibitor and Wnt Pathway Modulator for Treatment of Knee Osteoarthritis: A Phase 2 Randomized Trial
ConclusionThis Phase 2a, proof ‐of‐concept trial did not meet its primary endpoint; however, it identified a target population in which to evaluate the potential efficacy of lorecivivint. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 20, 2020 Category: Rheumatology Authors: Yusuf Yazici, Timothy E. McAlindon, Allan Gibofsky, Nancy E. Lane, Daniel Clauw, Morgan Jones, John Bergfeld, Christopher J. Swearingen, Anita DiFrancesco, Ismail Simsek, Jeyanesh Tambiah, Marc C. Hochberg Tags: FULL LENGTH Source Type: research

Cutaneous manifestations of anti ‐neutrophil cytoplasmic antibody‐associated vasculitis
This study describes the dermatologic features of AAV and their asso ciation with systemic manifestations of vasculitis.MethodsA cross ‐sectional study describing and comparing the cutaneous manifestations of AAV was performed using data from a large, international, collaborative effort to collect comprehensive clinical data on patients with vasculitis.ResultsData from 1184 patients with AAV from 130 centers worldwide were available. Cutaneous manifestations were common in all AAV subtypes: GPA (223/656; 34%), MPA (85/302; 28%), and EGPA (106/226; 47%). The most frequent cutaneous manifestation in AAV (all types) was pet...
Source: Arthritis and Rheumatology - May 18, 2020 Category: Rheumatology Authors: Robert G Micheletti, Zelma Chiesa Fuxench, Anthea Craven, Richard A Watts, Raashid A Luqmani, Peter A Merkel, The Diagnostic, Classification Criteria in Vasculitis Study (DCVAS) Investigators Tags: BRIEF REPORT Source Type: research

Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in the Rheumatoid Hand with Active Arthritis
AbstractObjectiveAssess differences in lymphatic function of RA hands with active synovitis versus healthy controls (Ctl) via near infrared ‐indocyanine green (NIR‐ICG) imaging.MethodsNIR imaging of 13 Ctl and 8 RA subjects with active disease was performed following web space injection of 0.1ml of 100 μM ICG. Percent ICG retention from the web spaces was determined via NIR imaging at baseline and 7±1 day after the initial injections; image analysis provided contraction frequency. ICG+ LV length and branching architecture.ResultsRetention of ICG in RA hands increased compared to Ctl (84 ±28% vs. 53&plu...
Source: Arthritis and Rheumatology - May 18, 2020 Category: Rheumatology Authors: Richard D. Bell, Homaira Rahimi, H. Mark Kenney, Alicia A. Lieberman, Ronald W. Wood, Edward M. Schwarz, Christopher T. Ritchlin Tags: FULL LENGTH Source Type: research

Efficacy and Safety of PF ‐06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor in Patients with Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate
AbstractObjectiveThis Phase 2a, 8 ‐week, double‐blind, parallel‐group study evaluated the efficacy and safety of PF‐06651600 (ritlecitinib), an irreversible inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family, versus placebo, in patients with rheumatoid arthrit is (RA).MethodsSeventy patients, seropositive for anticitrullinated protein antibodies and/or rheumatoid factor, were randomized 3:2 to receive oral PF ‐06651600 (200 mg once daily [QD]) or placebo for 8 weeks. Patients had an inadequate response to methotrexate and up to 50% could have ...
Source: Arthritis and Rheumatology - May 18, 2020 Category: Rheumatology Authors: Michael F. Robinson, Nemanja Damjanov, Bojana Stamenkovic, Goran Radunovic, Alan Kivitz, Lori Cox, Zorayr Manukyan, Christopher Banfield, Michael Saunders, Deepa Chandra, Michael S. Vincent, Jessica Mancuso, Elena Peeva, Jean S. Beebe Tags: FULL LENGTH Source Type: research

Deletion of c ‐Jun N‐terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age‐Related Osteoarthritis in Mice
ConclusionJNK1 and JNK2 are not required for the development of OA in the mouse DMM model. Deletion ofJNK1 orJNK2 is associated with more severe age ‐related OA and increased cell senescence suggesting JNK may act as a negative regulator of senescence in the joint. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 17, 2020 Category: Rheumatology Authors: Richard F. Loeser, Kathryn L. Kelley, Alexandra Armstrong, John A. Collins, Brian O. Diekman, Cathy S. Carlson Tags: FULL LENGTH Source Type: research

Intra ‐articular AAV‐PHP.S mediated chemogenetic targeting of knee‐innervating dorsal root ganglion neurons alleviates inflammatory pain in mice
ConclusionsWe describe an AAV ‐mediated chemogenetic approach to specifically control joint pain, which may be utilized in translational arthritic pain research. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 17, 2020 Category: Rheumatology Authors: Sampurna Chakrabarti, Luke A. Pattison, Balint Doleschall, Rebecca H. Rickman, Helen Blake, Gerard Callejo, Paul A. Heppenstall, Ewan St. John Smith Tags: FULL LENGTH Source Type: research

Unilateral hippocratic fingers and macaroni ‐sign
AbstractA 17 ‐year old girl presented to our emergency department with pain in her left arm and finger swelling of her left hand, which she had noticed for about 2 weeks. Patient’s history was otherwise unremarkable. Notably, there were no symptoms of systemic inflammation (night sweats, fever or weight loss ). (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 17, 2020 Category: Rheumatology Authors: Christian Lottspeich, Michael Czihal, Annette Friederike Jansson, Ava Oberlack Tags: CLINICAL IMAGE Source Type: research

TNF Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease Associated Pulmonary Arterial Hypertension (CTD ‐PAH)
AbstractObjectiveConnective tissue disease (CTD) associated pulmonary arterial hypertension (PAH) is the second most common etiology of PAH and carries a poor prognosis. Recently, it has been shown that female human TNF ‐transgenic (TNF‐Tg) mice die by 6‐months from cardiopulmonary disease. We aimed to characterize this pathophysiology and assess its potential as a novel model of CTD‐PAH.MethodsHistologic analysis was performed on TNF ‐Tg and wild type mice to characterize the pulmonary vascular and right ventricular pathology (n=40, 4‐5 mice per group/time point). Mice underwent right heart catheterization (n=...
Source: Arthritis and Rheumatology - May 10, 2020 Category: Rheumatology Authors: Richard D. Bell, R. James White, Maria L. Garcia ‐Hernandez, Emily Wu, Homaira Rahimi, Roberta G. Marangoni, Pamela Slattery, Stacey Duemmel, Marc Nuzzo, Nelson Huertas, Min Yee, Michael A. O’Reilly, Craig Morrell, Christopher T. Ritchlin Tags: FULL LENGTH Source Type: research

Insulin ‐Resistant Pathways Are Associated With Disease Activity in Rheumatoid Arthritis and Are Subject to Disease Modification Through Metabolic Reprogramming: A Potential Novel Therapeutic Approach
ObjectiveTo investigate a role for insulin ‐resistant pathways in inflammation and therapeutic targeting for disease modification in rheumatoid arthritis (RA).MethodsRA disease activity and cardiovascular risk factors, including insulin resistance and body mass index (BMI), were assessed in an Irish RA cohort. Glucose transporter 1 (GLUT ‐1) and GLUT‐4 activity in RA and osteoarthritis (OA) synovial tissue was examined using immunohistochemistry. Spontaneous release of proinflammatory mediators from ex vivo RA synovial explants and primary synovial fibroblast (SF) cell culture supernatants was quantified by enzyme‐...
Source: Arthritis and Rheumatology - May 10, 2020 Category: Rheumatology Authors: Lorna Gallagher, Sian Cregan, Monika Biniecka, Clare Cunningham, Douglas J. Veale, David J. Kane, Ursula Fearon, Ronan H. Mullan Tags: Brief Report Source Type: research

2020 American College of Rheumatology Guideline for the Management of Gout
AbstractObjectiveTo provide guidance for the management of gout including indications for and optimal use of urate ‐lowering therapy (ULT), treatment of gout flares, and lifestyle and other medication recommendations.MethodsFifty ‐seven patient intervention comparator outcome (PICO) questions were developed. This was followed by a systematic literature review including network meta‐analyses with rating of the available evidence according to GRADE methodology, and patient input. A group consensus process was used to compo se the final recommendations and grade their strength as strong or conditional.ResultsForty ‐tw...
Source: Arthritis and Rheumatology - May 10, 2020 Category: Rheumatology Authors: John D. FitzGerald, Nicola Dalbeth, Ted Mikuls, Romina Brignardello ‐Petersen, Gordon Guyatt, Aryeh M. Abeles, Allan C. Gelber, Leslie R. Harrold, Dinesh Khanna, Charles King, Gerald Levy, Caryn Libbey, David Mount, Michael H. Pillinger, A Tags: FULL LENGTH Source Type: research

Lip edema in a young female: an unusual cause
AbstractA 16 ‐year old female presented with persistent, painless swelling of both upper and lower lips, with intermittent spontaneous bleeding, for the past 6 months (Fig.1A). Examination revealed soft, non‐tender, erythematous swollen lips; systemic examination was unremarkable. The differentials to be con sidered in this patient are angioedema, cheilitis granulomatosa, sarcoidosis, Crohn’s disease, infections like tuberculosis, IgG4‐related disease and malignancy. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 7, 2020 Category: Rheumatology Authors: Rasmi Ranjan Sahoo, Kasturi Hazarika, Kunal Chandwar, Dogga Prasanna, Anupam Wakhlu Tags: CLINICAL IMAGE Source Type: research

Widening Disparities Among Patients with Rheumatic Diseases in the COVID ‐19 Era: An Urgent Call to Action
AbstractRecent data from multiple public health departments across the U.S. highlighting the disproportionate burden of COVID ‐19 infections in vulnerable populations serve as an urgent call to action. As rheumatologists, we are acutely aware of the higher morbidity and mortality, and for a number of our diseases, the higher incidence and prevalence among racial/ethnic minorities and individuals of lower socioeconomic st atus (SES). Comorbidities are frequent, timely access to subspecialty care is limited, receipt of high quality care is less common, and care is more often fragmented with frequent, avoidable acute care u...
Source: Arthritis and Rheumatology - May 7, 2020 Category: Rheumatology Authors: Candace H. Feldman, Rosalind Ramsey ‐Goldman Tags: NOTES FROM THE FIELD Source Type: research

Cardiac Intravoxel Incoherent Motion Diffusion ‐Weighted Magnetic Resonance Imaging With T1 Mapping to Assess Myocardial Perfusion and Fibrosis in Systemic Sclerosis: Association with Cardiac Events From a Prospective Cohort Study
ConclusionThis study shows the interest of CMRI with T1 mapping  sequences and IVIM DWI in SSc to assess myocardial involvement. Increased T1 values, potentially suggesting microscopic fibrosis, was more frequently observed in patients with dcSSc and was associated with interstitial lung disease, and with more frequent cardiac events during follow‐up. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 7, 2020 Category: Rheumatology Authors: Benjamin Terrier, Agn ès Dechartres, Hervé Gouya, Moncef Ben Arfi, Alice Bérézne, Alexis Régent, Bertrand Dunogué, Jonathan London, Pascal Cohen, Loïc Guillevin, Claire Le Jeunne, Paul Legmann, Olivier Vignaux, Luc Mouthon Tags: FULL LENGTH Source Type: research

Evan Calkins, MD, 1920 ‐2020
AbstractDr. Evan Calkins passed away on January 24, 2020 at the age of 99. He was a revered leader in the Buffalo, NY community ‐ a passionate and talented educator and an innovator in both rheumatology and geriatrics. He was raised in Newton, Massachusetts where he attended elementary school with Norman Mailer and Ben Bradlee. He received his undergraduate degree from Harvard (cum laude) and medical degree from Harvard Me dical School (cum laude). Following graduation from medical school, he served as an army Captain during World War II. He then completed a residency in internal medicine at Johns Hopkins Hospital and a ...
Source: Arthritis and Rheumatology - May 6, 2020 Category: Rheumatology Authors: Christopher T Ritchlin Tags: IN MEMORIAM Source Type: research

Biosimilar Uptake in Academic and Veterans Health Administration Settings: Influence of Institutional Incentives
ConclusionThe uptake of infliximab biosimilars has been slow at an academic medical center compared to a nearby VAMC, where financial savings are realized by the institution from its use. Slow adoption of biosimilar medications may impact the rates of decline in costs. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 5, 2020 Category: Rheumatology Authors: Joshua F. Baker, Charles E. Leonard, Vincent Lo Re, Michael H. Weisman, Michael D. George, Jonathan Kay Tags: Brief Report Source Type: research

Lenabasum for skin disease in patients with diffuse cutaneous systemic sclerosis
This study is important because it exami nes the effects of cannabinoid (CB) modulation in SSc, a hitherto unexplored pathway, it uses the American College of Rheumatology (ACR) Combined Response Index in Systemic Sclerosis (CRISS) index as an outcome in a 12‐week as opposed to its intended use in 12‐month clinical trials, and it redem onstrates the utility of obtaining skin biopsies to assess secondary outcomes in SSc clinical trials. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 5, 2020 Category: Rheumatology Authors: Monique Hinchcliff Tags: EDITORIAL Source Type: research

Introducing the New Editor of Arthritis & Rheumatology, Daniel H. Solomon, MD, MPH
Arthritis& Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 5, 2020 Category: Rheumatology Authors: Ellen M. Gravallese Tags: Original Article Source Type: research

A Spatiotemporal Analysis of Organ ‐Specific Lupus Flares in Relation to Atmospheric Variables and Fine Particulate Matter Pollution
ObjectiveTo identify potential clusters of systemic lupus erythematosus (SLE) organ ‐specific flares and their relationship to fine particulate matter pollution (PM2.5), temperature, ozone concentration, resultant wind, relative humidity, and barometric pressure in the Hopkins Lupus Cohort, using spatiotemporal cluster analysis.MethodsA total of 1,628 patients who fulfilled the Systemic Lupus International Collaborating Clinics classification criteria for SLE and who had a home address recorded were included in the analysis. Disease activity was assessed using the Lupus Activity Index. Assessment of rash, joint involveme...
Source: Arthritis and Rheumatology - May 2, 2020 Category: Rheumatology Authors: George Stojan, Anton Kvit, Frank C. Curriero, Michelle Petri Tags: Original Article Source Type: research

Role of Chondrocytes in the Development of Rheumatoid Arthritis Via Transmembrane Protein 147 –Mediated NF‐κB Activation
This study was undertaken to examine the role of NF‐κB activation in chondrocytes and better understand the pathogenesis of RA. Furthermore, transmembrane protein 147 (TMEM147) was investigated as a representative NF‐κB activator in chondrocytes.MethodsClinical samples from RA patients were analyzed by immunohistochemistry. Specimens obtained from patients with polydactyly were used as control samples. The functional contribution of chondrocytes and TMEM147 to arthritis was examined in several murine models of RA. In vitro experiments (quantitative polymerase chain reaction, RNA interference, immunoprecipit...
Source: Arthritis and Rheumatology - May 2, 2020 Category: Rheumatology Authors: Mitsutoshi Ota, Yuki Tanaka, Ikuma Nakagawa, Jing ‐Jing Jiang, Yasunobu Arima, Daisuke Kamimura, Tomohiro Onodera, Norimasa Iwasaki, Masaaki Murakami Tags: Original Article Source Type: research

Poly(ADP ‐Ribose) Polymerase Enhances Infiltration of Mononuclear Cells in Primary Sjögren's Syndrome Through Interferon‐Induced Protein With Tetratricopeptide Repeats 1–Mediated Up‐Regulation of CXCL10
ConclusionThis study is the first to implicate PARP ‐9 as a regulator of infiltration of mononuclear cells in primary SS progression and to reveal that PARP‐9 increases CXCL10 expression through up‐regulating IFIT‐1, which is mediated by the phosphorylation of STAT1. PARP‐9 might therefore be a novel therapeutic target for primary SS. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 2, 2020 Category: Rheumatology Authors: Qingqing Tian, Han Zhao, Hanzhi Ling, Li Sun, Chipeng Xiao, Guoyu Yin, Xiaobing Wang, Gan Wu, Chenglin Yang, Mu Chen, Shengwei Jin, Xinyu Yang, Jianguang Wang Tags: Original Article Source Type: research

Blockade of Discoidin Domain Receptor 2 as a Strategy for Reducing Inflammation and Joint Destruction in Rheumatoid Arthritis Via Altered Interleukin ‐15 and Dkk‐1 Signaling in Fibroblast‐Like Synoviocytes
This study was undertaken to uncover the pathophysiologic role of discoidin domain receptor 2 (DDR ‐2), a putative fibrillar collagen receptor, in inflammation promotion and joint destruction in rheumatoid arthritis (RA).MethodsIn synovial tissue from patients with RA and from mice with collagen antibody –induced arthritis (CAIA) (usingDdr2−/− and DBA/1 mice), gene and protein expression levels of DDR ‐2, interleukin‐15 (IL‐15), and Dkk‐1 were measured by quantitative reverse transcription–polymerase chain reaction, Western blotting, and immunohistochemistry. Gene knockdown ofDDR2 in human...
Source: Arthritis and Rheumatology - May 2, 2020 Category: Rheumatology Authors: Nan Mu, Jin ‐Tao Gu, Tong‐Lie Huang, Nan‐Nan Liu, Hui Chen, Xin Bu, Zhao‐Hui Zheng, Bo Jia, Jun Liu, Bao‐Long Wang, Ying‐Mei Wang, Zhen‐Feng Zhu, Yong Zhang, Ying‐Qi Zhang, Xiao‐Chang Xue, Meng Li, Wei Zhang Tags: Original Article Source Type: research

Do Serum Urate –Associated Genetic Variants Differentially Contribute to Gout Risk According to Body Mass Index? Analysis of the UK Biobank
ObjectiveTo examine whether urate ‐associated genetic variants differ in their influence on gout risk according to body mass index (BMI).MethodsThis research was conducted using the UK Biobank Resource (n = 358,728). Participants were divided into 3 groups: BMI
Source: Arthritis and Rheumatology - May 2, 2020 Category: Rheumatology Authors: Vicky Tai, Ravi K. Narang, Greg Gamble, Murray Cadzow, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth Tags: Original Article Source Type: research

DNA Vaccination With Hsp70 Protects Against Systemic Lupus Erythematosus in (NZB × NZW)F1 Mice
ConclusionDNA vaccination with Hsp70 suppresses murine lupus by inducing tolerogenic immune responses and antiinflammatory immune responses associated with reduced disease manifestations and increased mouse survival. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 30, 2020 Category: Rheumatology Authors: Aijing Liu, Concetta Ferretti, Fu ‐Dong Shi, Irun R. Cohen, Francisco J. Quintana, Antonio La Cava Tags: Brief Report Source Type: research

Promotion of Myofibroblast Differentiation and Tissue Fibrosis by the Leukotriene B4 –Leukotriene B4 Receptor Axis in Systemic Sclerosis
ObjectiveTo investigate the role of the inflammatory lipid mediator leukotriene B4 (LTB4) and its receptor, BLT1, in the development and progression of systemic sclerosis (SSc).MethodsSerum levels of LTB4 were compared in 64 patients with SSc and 80 healthy controls. Skin and lung tissue sections from patients with SSc and healthy donors were immunostained for leukotriene A4 hydrolase (LTA4H), the critical enzyme for LTB4 synthesis, and BLT1, in combination with different cell markers. In mouse models of SSc using bleomycin or angiotensin II challenge or immunization with the DNA topoisomerase I, genetic or pharmacologic i...
Source: Arthritis and Rheumatology - April 30, 2020 Category: Rheumatology Authors: Minrui Liang, Jiaoyan Lv, Zhixing Jiang, Hang He, Chen Chen, Yinluo Xiong, Xiaoxia Zhu, Yu Xue, Yiyun Yu, Sen Yang, Lingbiao Wang, Wenjing Li, Ming Guan, Weiguo Wan, Rui He, Hejian Zou Tags: Original Article Source Type: research

American College of Rheumatology Guidance for the Management of Adult Patients with Rheumatic Disease During the COVID ‐19 Pandemic
ConclusionThese guidance statements are provided to promote optimal care during the current pandemic. However, given the low level of available evidence and the rapidly evolving literature, this guidance is presented as a “living document” and future updates are anticipated. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 29, 2020 Category: Rheumatology Authors: Ted R. Mikuls, Sindhu R Johnson, Liana Fraenkel, Reuben J. Arasaratnam, Lindsey R. Baden, Bonnie L. Bermas, Winn Chatham, Stanley Cohen, Karen Costenbader, Ellen M. Gravallese, Andre C. Kalil, Michael E. Weinblatt, Kevin Winthrop, Amy S. Muda Tags: FULL LENGTH Source Type: research

High Serum Interleukin ‐6 is Associated With Severe Progression of Rheumatoid Arthritis and Increased Treatment Response Differentiating Sarilumab from Adalimumab or Methotrexate in a Post Hoc Analysis
ConclusionIL ‐6 may be a prognostic marker of disease progression and severity, and patients with high IL‐6 may be likely to benefit from sarilumab compared with adalimumab or methotrexate. Prospective validation is warranted to confirm the results of these post hoc analyses. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 28, 2020 Category: Rheumatology Authors: Anita Boyapati, Sergio Schwartzman, J érôme Msihid, Ernest Choy, Mark C. Genovese, Gerd R. Burmester, Gordon Lam, Toshio Kimura, Jonathan Sadeh, David M. Weinreich, George D. Yancopoulos, Neil M.H. Graham Tags: FULL LENGTH Source Type: research

Periorbital xanthelasmas, bilateral retro ‐orbital masses, bone and retroperitoneal infiltration: can you guess it?
AbstractA 46 ‐year‐old man with no relevant medical history presented to the Emergency Department with a headache, retro‐orbital pain, progressive proptosis and periorbital xanthelasmas. He denied bone pain nor any symptoms of diabetes insipidus. An ESR was 40 mm/hour and a CRP was 2.8 mg/dL. A non‐contr ast head CT demonstrated bilateral retro‐orbital masses. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 28, 2020 Category: Rheumatology Authors: Marina Lozano Ros Tags: CLINICAL IMAGE Source Type: research

Issue Information
Arthritis& Rheumatology, Volume 72, Issue 5, May 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 27, 2020 Category: Rheumatology Tags: Issue Information Source Type: research

Clinical Connections
Arthritis& Rheumatology, Volume 72, Issue 5, May 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 27, 2020 Category: Rheumatology Tags: Clinical Connections Source Type: research

In This Issue
Arthritis& Rheumatology, Volume 72, Issue 5, May 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 27, 2020 Category: Rheumatology Tags: In This Issue Source Type: research