Epicardial Adipose Tissue Volume As a Marker of Subclinical Coronary Atherosclerosis in Rheumatoid Arthritis
ObjectiveTo assess epicardial adipose tissue volume (EATV) and its link to coronary atherosclerosis and plaque morphology in patients with rheumatoid arthritis (RA) and in age- and sex-matched controls.MethodsComputed tomography angiography was used to evaluate EATV and coronary plaque in 139 RA patients and 139 non-RA controls. All models assessing the effect of EATV on plaque were adjusted for age, sex, hypertension, diabetes, dyslipidemia, smoking status, family history of coronary artery disease, and obesity (body mass index of ≥30 kg/m2). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.Resu...
Source: Arthritis and Rheumatology - June 24, 2021 Category: Rheumatology Authors: George A. Karpouzas, Panteha Rezaeian, Sarah R. Ormseth, Ivana Hollan, Matthew J. Budoff Tags: Full Length Source Type: research

A worldwide pharmacoepidemiological update of drug ‐associated ANCA‐associated vasculitis at the time of targeted therapies
ConclusionThis study strengthens the previously suspected association but also identifies 3 new drugs that may cause DA-AAV. Particular attention should be given to these drugs by prescribers and in experimental studies. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2021 Category: Rheumatology Authors: Samuel Deshayes, Charles Dolladille, Ana ël Dumont, Nicolas Martin Silva, Basile Chretien, Hubert De Boysson, Joachim Alexandre, Achille Aouba Tags: FULL LENGTH Source Type: research

Phase IIa Global Study Evaluating Rituximab for the Treatment of Pediatric Patients With Granulomatosis With Polyangiitis or Microscopic Polyangiitis
ConclusionIn pediatric patients, rituximab was well tolerated and effective with an overall safety profile comparable with that of rituximab-treated adult patients with GPA or MPA. Rituximab was associated with a positive benefit-risk profile for use in pediatric patients with active GPA or MPA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2021 Category: Rheumatology Authors: Paul Brogan, Rae S. M. Yeung, Gavin Cleary, Satyapal Rangaraj, Ozgur Kasapcopur, Aimee O. Hersh, Suzanne Li, Dusan Paripovic, Kenneth Schikler, Andrew Zeft, Claudia Bracaglia, Despina Eleftheriou, Pooneh Pordeli, Simone Melega, Candice Jamoi Tags: FULL LENGTH Source Type: research

EMBRACE: Phase 3/4, Randomized, 52 ‐Week Study of Belimumab Efficacy and Safety in Patients of Black African Ancestry With Systemic Lupus Erythematosus
ConclusionsThe primary endpoint of this study was not achieved, but improvement with belimumab versus placebo was observed, suggesting that belimumab remains a suitable treatment option for SLE management in patients of Black African ancestry. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2021 Category: Rheumatology Authors: Ellen Ginzler, Luiz Sergio Guedes Barbosa, David D ’Cruz, Richard Furie, Kathleen Maksimowicz‐McKinnon, James Oates, Mittermayer Barreto Santiago, Amit Saxena, Saira Sheikh, Damon L. Bass, Susan W. Burriss, Jennifer A. Gilbride, James G. G Tags: FULL LENGTH Source Type: research

Anti ‐dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles
ConclusionDNA bound to HLA class II molecules is involved in SLE pathogenesis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2021 Category: Rheumatology Authors: Hideaki Tsuji, Koichiro Ohmura, Hui Jin, Ryota Naito, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Shuhei Sakakibara, Yuta Kochi, Yukinori Okada, Kazuhiko Yamamoto, Hitoshi Kikutani, Akio Morinobu, Tsuneyo Mimori, Hisashi Arase Tags: BRIEF REPORT Source Type: research

Industry Payments to Practicing US Rheumatologists, 2014 ‐2019
The objective of this study was to investigate the nature, quantity, and geographical distribution of payments to US rheumatologists.MethodsGeneral payments from industry sponsors to US rheumatologists from 2014-2019 were extracted from the Centers for Medicare& Medicaid Services (CMS) Open Payments database. Gender was identified by linking physicians to the National Plan and Provider Enumeration System (NPPES) registry. Data were reported in aggregate, trends over time were assessed using linear regression models, and differences by gender were analyzed using the Wilcoxon rank-sum test.ResultsOver the six-year time p...
Source: Arthritis and Rheumatology - June 24, 2021 Category: Rheumatology Authors: Michael S. Putman, Jay E. Goldsher, Cynthia S. Crowson, Al í Duarte‐García Tags: FULL LENGTH Source Type: research

Industry Payments to Rheumatologists Ought to be Going Down, Not Up
AbstractIn the current issue ofArthritis& Rheumatology, Putman et al report findings regarding the distribution and temporal trends of industry payments to US rheumatologists [cite ar-21-0182]. Their findings are in line with similar reports from other medical and surgical specialties, and highlight the overarching concern regarding the ability of industry payments to adversely affect care quality within the specific context of rheumatology practice. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2021 Category: Rheumatology Authors: Aaron P. Mitchell Tags: EDITORIAL Source Type: research

Outcomes of a Mobile App to Monitor Patient ‐Reported Outcomes in Rheumatoid Arthritis: A Randomized Controlled Trial
ConclusionA mobile app designed to collect ePRO data on RA symptoms did not significantly improve patient satisfaction or disease activity compared to care coordination alone. However, both patients and physicians reported positive experiences with the app. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 19, 2021 Category: Rheumatology Authors: Yvonne C. Lee, Fengxin Lu, Joshua Colls, Dee Luo, Penny Wang, Dorothy D. Dunlop, Lutfiyya  N. Muhammad, Jing Song, Kaleb Michaud, Daniel H. Solomon Tags: Full Length Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 17, 2021 Category: Rheumatology Authors: Weiyang Tao, Timothy R. D. J. Radstake, Aridaman Pandit Tags: Letters Source Type: research

American College of Rheumatology Guidance for COVID ‐19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 2
ConclusionThese guidance statements, made in the context of limited clinical data, are intended to provide direction to rheumatology health care providers on how to best use COVID-19 vaccines and to facilitate implementation of vaccination strategies for RMD patients. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 15, 2021 Category: Rheumatology Authors: Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Andrew Kroger, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Tags: Full Length Source Type: research

Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis
ConclusionWe report a serum protein biomarker panel which can separate EIA patients with PsA from those with RA. With continued evaluation and refinement using additional and larger patient cohorts including those with other arthropathies we suggest the panel identified here could contribute toward improved clinical decision making. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 11, 2021 Category: Rheumatology Authors: Angela Mc Ardle, Anna Kwasnik, Agnes Szenpetery, Belinda Hernandez, Andrew Parnell, Wilco de Jager, Sytze de Roock, Oliver FitzGerald, Stephen R. Pennington Tags: FULL LENGTH Source Type: research

Expert Perspective: Management of Microvascular and Catastrophic Antiphospholipid Syndrome
AbstractA 50-year-old male with antiphospholipid syndrome (APS) presents to your office for the first time with a three-month history of worsening dyspnea, dry cough, and early morning blood-tinged sputum. His APS diagnosis was based on an unprovoked left lower extremity deep vein thrombosis, four years prior to the presentation, with persistent (multiple occasions) triple antiphospholipid antibody (aPL)-positivity, defined as lupus anticoagulant (LA) test positive performed while off anticoagulation, high titer [ ≥80 U] IgG anticardiolipin antibodies (aCL), and high titer IgG anti–β2-glycoprotein-I (a β...
Source: Arthritis and Rheumatology - June 11, 2021 Category: Rheumatology Authors: Doruk Erkan Tags: EXPERT PERSPECTIVES ON CLINICAL CHALLENGES Source Type: research

American College of Rheumatology Guidance for the Management of Pediatric Rheumatic Disease During the COVID ‐19 Pandemic: Version 2
ConclusionThese guidance statements have been generated based on review of the available literature, indicating that children with PRD do not appear to be at increased risk for susceptibility to SARS –CoV-2 infection. This guidance is presented as a “living document,” recognizing that the literature on COVID-19 is rapidly evolving, with future updates anticipated. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 11, 2021 Category: Rheumatology Authors: Dawn M. Wahezi, Mindy S. Lo, Tamar B. Rubinstein, Sarah Ringold, Stacy P. Ardoin, Kevin  J. Downes, Karla B. Jones, Ronald M. Laxer, Rebecca Pellet Madan, Amy S. Mudano, Amy S. Turner, David R. Karp, Jay J. Mehta Tags: Full Length Source Type: research

Predicting Risk of Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: CSTAR Cohort Study
ConclusionWe developed a risk stratification model using routine clinical assessments. This new tool may effectively predict the future risk of pulmonary arterial hypertension in patients with systemic lupus erythematosus. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Jingge Qu, Mengtao Li, Yanhong Wang, Xinwang Duan, Hui Luo, Cheng Zhao, Feng Zhan, Zhenbiao Wu, Hongbin Li, Min Yang, Jian Xu, Wei Wei, Lijun Wu, Yongtai Liu, Hanxiao You, Juyan Qian, Xiaoxi Yang, Can Huang, Jiuliang Zhao, Qian Wang, X Tags: FULL LENGTH Source Type: research

The Childhood Arthritis & Rheumatology Research Alliance Start Time Optimization of Biologics in Polyarticular Juvenile Idiopathic Arthritis Study (STOP ‐JIA): A Comparative Effectiveness Study of CARRA Consensus Treatment Plans for Untreated Polyarticular JIA
ConclusionsAchievement of CID off GC did not significantly differ between groups at 12 months. While there was a statistically significant higher likelihood of EC achieving cJADAS10 ID and pACR70, these results require further exploration. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Yukiko Kimura, Laura E. Schanberg, George A. Tomlinson, Mary Ellen Riordan, Anne C. Dennos, Vincent Del Gaizo, Katherine L. Murphy, Pamela F. Weiss, Marc D. Natter M, Brian M. Feldman, Sarah Ringold, The CARRA STOP ‐JIA Investigators, Heidi Tags: FULL LENGTH Source Type: research

The DNA methylation Profile of Undifferentiated Arthritis Patients Anticipates their Subsequent Differentiation to Rheumatoid Arthritis
ConclusionDNA methylation profiling provides a good predictor of UA-to-RA progression to anticipate targeted treatments and improve clinical management. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Carlos de la Calle ‐Fabregat, Ellis Niemantsverdriet, Juan D. Cañete, Tianlu Li, Annette H. M. van der Helm‐van Mil, Javier Rodríguez‐Ubreva, Esteban Ballestar Tags: FULL LENGTH Source Type: research

Clinical and methodological considerations on the results of the SENSCIS trial: Comment on the article by Maher et al.
AbstractI read with interest the reanalysis of the results of the SENSCIS trial, published by Maher et al (1). The article may represent an advance in the knowledge of the effects of nintedanib in systemic sclerosis-associated interstitial lung disease (SSc-ILD), but there are aspects that deserve additional comments. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Markus Bredemeier Tags: LETTER TO THE EDITOR Source Type: research

Improved disease course associated with early initiation of biologics in untreated polyarticular Juvenile Idiopathic Arthritis: A trajectory analysis of the STOP ‐JIA study
ConclusionStarting bDMARDs within 3 months of baseline assessment is associated with more rapid achievement of inactive disease in subjects with untreated pJIA. These results demonstrate the utility of trajectory analysis of disease course as a method for determining treatment efficacy. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Mei Sing Ong, Sarah Ringold, Yukiko Kimura, Laura E. Schanberg, George A. Tomlinson, Marc D. Natter, The CARRA Registry Investigators, N. Abel, K. Abulaban, A. Adams, M. Adams, R. Agbayani, J. Aiello, S. Akoghlanian, C. Alejandro, E. Allens Tags: FULL LENGTH Source Type: research

Effect of nintedanib on lung function in patients with systemic sclerosis ‐associated interstitial lung disease: further analyses of a randomized, double‐blind, placebo‐controlled trial
AbstractFollowing the publication of further analyses of the effects of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) in the SENSCIS trial (1), Dr Bredemeier queried whether the occurrence of gastrointestinal adverse events in subjects treated with nintedanib may have reduced the effectiveness of masking and so introduced bias (2). (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Toby M Maher, Maureen D Mayes, Christian Stock, Margarida Alves Tags: REPLY Source Type: research

The ciliary protein IFT88 controls post ‐natal cartilage thickness and influences development of osteoarthritis.
AbstractObjectiveMechanical and biological cues drive cellular signalling in cartilage development, health, and disease.  Proteins of the primary cilium, implicated in transduction of biophysiochemical signals, control cartilage formation during skeletal development, but their influence in post-natal cartilage remains unknown.MethodsIft88fl/fl andAggrecanCreERT2 mice were crossed to create a cartilage-specific, inducible knockout mouseAggrecanCreERT2;Ift88fl/fl. Tibial articular cartilage (AC) thickness was assessed, through adolescence and adulthood, by histomorphometry and integrity by OARSI score.In situ ...
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Clarissa R Coveney, Linyi Zhu, Jadwiga Miotla ‐Zarebska, Bryony Stott, Ida Parisi, Vicky Batchelor, Claudia Duarte, Emer Chang, Eleanor McSorley, Tonia L Vincent, Angus KT Wann Tags: FULL LENGTH Source Type: research

Response to: ‘Effectiveness of allopurinol on reducing mortality: Time‐related biases in observational studies’
AbstractWe read with great interest the manuscript by Suissa et al that reviewed observational studies of the association between allopurinol and mortality in individuals with gout (1). Suissa describes immeasurable time bias as time periods during which prescription medication records are not available (e.g. hospitalizations), leading to at-risk time being potentially misclassified as unexposed-time. Suissa recommends accounting for the possibility of immeasurable time bias by evaluating hospitalizations during follow-up or using an analytic approach that is weighted by measurable time (2). (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Alanna Weisman, Gillian A. Hawker, George A. Tomlinson Tags: LETTER TO THE EDITOR Source Type: research

American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID ‐19 Pandemic: Version 3: Comment on the Article by Mikuls et al
AbstractIt is with great pleasure that we read the work by Mikuls and colleagues (1) regarding pertinent consensus-based guidelines for managing rheumatic diseases under the context of COVID-19. We would first like to note that our nationwide retrospective cohort studies have shown that hydroxychloroquine treatment not only presents no increased risk of cardiac arrythmia in multiple rheumatic diseases (2), but also likely provides cardiovascular protection (3). Therefore, we believe the task force should reconsider the implications of halting hydroxychloroquine treatment in the context of SARS-CoV-2 infection. (Source: Art...
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Jeffrey Hsu, Chin ‐Hsiu Liu, James C. Wei Tags: LETTER TO THE EDITOR Source Type: research

IRE1 α‐mediated monounsaturated fatty acid synthesis drives B cell differentiation and lupus‐like autoimmune disease
ConclusionOur study reveals a molecular link of lipid metabolic dysregulation in lupus pathogenesis, demonstrates that the IRE1 α-XBP-1 pathway controls plasma cell differentiation through SCD1/2-mediated monounsaturated fatty acid synthesis, and provides a rationale for targeting IRE1α and monounsaturated fatty acid synthesis in lupus treatment. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Yana Zhang, Ming Gui, Yajun Wang, Nikita Mani, Shuvam Chaudhuri, Beixue Gao, Huabin Li, Yashpal S. Kanwar, Sarah A. Lewis, Sabrina N. Dumas, James M. Ntambi, Kezhong Zhang, Deyu Fang Tags: FULL LENGTH Source Type: research

A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL ‐40 ‐ IL‐13 Receptor α2 Axis
ConclusionIn GCA, a GM-CSF-skewed, CD206+MMP9+ macrophage subset expresses high levels of YKL-40 which may stimulate tissue destruction and angiogenesis through IL-13R α2 signaling. Targeting YKL-40 or GM-CSF may inhibit macrophages that are currently insufficiently suppressed by glucocorticoids. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Yannick van Sleen, William F. Jiemy, Sarah Pringle, Kornelis S.M. van der Geest, Wayel H. Abdulahad, Maria Sandovici, Elisabeth Brouwer, Peter Heeringa, Annemieke M.H. Boots Tags: FULL LENGTH Source Type: research

Reply to Weisman et al. on: “Effectiveness of allopurinol on reducing mortality: Time‐related biases in observational studies”. Arthritis Rheumatol 2021
AbstractWe thank Weisman et al for their letter regarding our review of the observational studies reporting on the effectiveness of allopurinol on reducing mortality, particularly the studies affected by immeasurable time bias.1,2 Indeed, our review explained that immeasurable time bias can be an important complexity in observational studies where the outcome is death and hospitalisations are frequent.3 (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Samy Suissa, Karine Suissa, Marie Hudson Tags: REPLY Source Type: research

Osteoarthritis care and risk of total knee arthroplasty among medicare beneficiaries
ConclusionsDedicated non-surgical osteoarthritis care was infrequently used by elderly Americans with knee osteoarthritis. Non-surgical care was more common in regions with low rates of TKA, suggesting reciprocal emphasis on medical versus surgical treatment across regions. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Michael M. Ward Tags: FULL LENGTH Source Type: research

Effects of the TNFRSF11B Mutation Associated With Calcium Pyrophosphate Deposition Disease in Osteoclastogenesis in a Murine Model
ConclusionThese findings indicate that OPG-XL is a loss-of-function mutation as it relates to RANKL-mediated osteoclastogenesis, and thus may permit increased osteoclast numbers and heightened bone turnover. Further studies are necessary to demonstrate how this mutation contributes to arthritis in individuals carrying this mutation. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 8, 2021 Category: Rheumatology Authors: Elizabeth Mitton ‐Fitzgerald, Claudia M. Gohr, Charlene J. Williams, Amaryllis Ortiz, Gabriel Mbalaviele, Ann K. Rosenthal Tags: Brief Report Source Type: research

Urate Lowering for Blood Pressure Control in Adults: Another Nail in the Coffin?
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 8, 2021 Category: Rheumatology Authors: Edward Roddy, Nicola Dalbeth Tags: Editorial Source Type: research

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
ConclusionThis clinical practice guideline is intended to serve as a tool to support clinician and patient decision-making. Recommendations are not prescriptive, and individual treatment decisions should be made through a shared decision-making process based on patients ’ values, goals, preferences, and comorbidities. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 8, 2021 Category: Rheumatology Authors: Liana Fraenkel, Joan M. Bathon, Bryant R. England, E. William St.Clair, Thurayya Arayssi, Kristine Carandang, Kevin D. Deane, Mark Genovese, Kent Kwas Huston, Gail Kerr, Joel Kremer, Mary C. Nakamura, Linda A. Russell, Jasvinder A. Singh, Be Tags: Original Article Source Type: research

Targeting the CCR6/CCL20 axis in entheseal and cutaneous inflammation
ConclusionsOur studies highlight the pathogenic role of CCR6-CCL20 axis in enthesitis and raise the prospect of a novel therapeutic approach for treating patients with PsO and PsA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 4, 2021 Category: Rheumatology Authors: Zhenrui Shi, Emma Garcia ‐Melchor, Xuesong Wu, Anthony E. Getschman, Mimi Nguyen, Douglas J. Rowland, Machelle Wilson, Flavia Sunzini, Moeed Akbar, Mindy Huynh, Timothy Law, Smriti K. Kundu‐Raychaudhuri, Siba P. Raychaudhuri, Brian F. Vol Tags: FULL LENGTH Source Type: research

Understanding the relationships between type I interferon, STAT4, and the production of interleukin ‐21 and interferon‐γ by follicular helper T cells in lupus: comment on the article by Dong et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 1, 2021 Category: Rheumatology Authors: Caiqun Chen, Zaixing Yang, Yan Liang Tags: Letters Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 1, 2021 Category: Rheumatology Authors: Joe Craft, Jason Weinstein Tags: Letters Source Type: research

Prophylactic anticoagulation therapy: comment on the article by Henderson et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 1, 2021 Category: Rheumatology Authors: Barbara Faganel Kotnik, Mojca Zajc Avramovi č, Lidija Kitanovski, Tadej Avčin Tags: Letters Source Type: research

Temporal arteritis revealing antineutrophil cytoplasmic antibody –associated vasculitides: are the visual outcomes different from giant cell arteritis? Comment on the article by Delaval et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 1, 2021 Category: Rheumatology Authors: Joydeep Samanta, GSRSNK Naidu, Sakshi Mittal, Ritambhra Nada, Amanjit Bal, Ramandeep Singh, Vishali Gupta, Amod Gupta, Aman Sharma, Benzeeta Pinto Tags: Letters Source Type: research

Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis
ConclusionHere, we identify a gene signature in systemic JIA patients prior to receiving treatment that distinguishes strong responders to canakinumab from nonresponders. Further prospective studies are needed to assess the utility of these insights for treatment decisions in systemic JIA and to track the association of up-regulated type I IFN signatures with systemic JIA complications. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 1, 2021 Category: Rheumatology Authors: Emely L. Verweyen, Alex Pickering, Alexei A. Grom, Grant S. Schulert Tags: Brief Report Source Type: research

Greater Somatosensory Afference With Acupuncture Increases Primary Somatosensory Connectivity and Alleviates Fibromyalgia Pain via Insular γ‐Aminobutyric Acid: A Randomized Neuroimaging Trial
ConclusionThe somatosensory component of acupuncture modulates primary somatosensory functional connectivity associated with insular neurochemistry to reduce pain severity in FM. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 1, 2021 Category: Rheumatology Authors: Ishtiaq Mawla, Eric Ichesco, Helge J. Z öllner, Richard A. E. Edden, Thomas Chenevert, Henry Buchtel, Meagan D. Bretz, Heather Sloan, Chelsea M. Kaplan, Steven E. Harte, George A. Mashour, Daniel J. Clauw, Vitaly Napadow, Richard E. Harris Tags: Original Article Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 1, 2021 Category: Rheumatology Authors: Lauren A. Henderson, Kevin G. Friedman, Mary Beth F. Son, Kate F. Kernan, Scott W. Canna, Mark Gorelik, Sivia K. Lapidus, Anne Ferris, Grant S. Schulert, Philip Seo, Adriana H. Tremoulet, Rae S. M. Yeung, David R. Karp, Hamid Bassiri, Edward Tags: Letters Source Type: research

Biologics for eosinophilic granulomatosis with polyangiitis —one size does not fit all: comment on the article by Canzian et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 31, 2021 Category: Rheumatology Authors: Marco Caminati, Alessandro Giollo, Gianenrico Senna, Claudio Lunardi Tags: Letters Source Type: research

Journal Club
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 30, 2021 Category: Rheumatology Tags: Journal Club Source Type: research

In This Issue
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 30, 2021 Category: Rheumatology Tags: In This Issue Source Type: research

Issue Information
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 30, 2021 Category: Rheumatology Tags: Issue Information Source Type: research

Clinical Connections
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 30, 2021 Category: Rheumatology Tags: Clinical Connections Source Type: research

Validation of a Bioassay for Predicting Response to Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 30, 2021 Category: Rheumatology Authors: Ching ‐Huang Ho, Andrea A. Silva, Jon T. Giles, Joan M. Bathon, Daniel H. Solomon, Katherine P. Liao, I‐Cheng Ho Tags: Concise Communication Source Type: research

Association of Higher Hydroxychloroquine Blood Levels With Reduced Thrombosis Risk in Systemic Lupus Erythematosus
This study was undertaken to examine the usefulness of HCQ blood monitoring in predicting thrombosis risk in a longitudinal SLE cohort.MethodsHCQ levels were serially quantified from EDTA whole blood by liquid chromatography –tandem mass spectrometry. The mean HCQ blood levels calculated prior to thrombosis or until the last visit were compared usingt-tests between patients with and those without thrombosis. Pooled logistic regression was used to analyze the association between rates of thrombosis and HCQ blood level. Rate ratios (RRs) and 95% confidence intervals (95% CIs) were calculated.ResultsIn 739 patients with...
Source: Arthritis and Rheumatology - May 30, 2021 Category: Rheumatology Authors: Michelle Petri, Maximilian F. Konig, Jessica Li, Daniel W. Goldman Tags: Full Length Source Type: research

The Vasculopathy of Juvenile Dermatomyositis: Endothelial Injury, Hypercoagulability, and Increased Arterial Stiffness
ObjectiveVasculopathy is considered central to the pathogenesis of juvenile dermatomyositis (DM) and is associated with severe extramuscular manifestations. We undertook this study to investigate the hypothesis that the vasculopathy of juvenile DM can be noninvasively tracked by examining biomarkers of endothelial injury, subclinical inflammation, hypercoagulability, and vascular arterial stiffness.MethodsThe study population was a UK cohort of children with juvenile DM. Circulating endothelial cells (CECs) and microparticles (MPs) were identified using immunomagnetic bead extraction and flow cytometry, respectively. Plasm...
Source: Arthritis and Rheumatology - May 28, 2021 Category: Rheumatology Authors: Charalampia Papadopoulou, Ying Hong, Petra Krol, Muthana Al Obaidi, Clarissa Pilkington, Lucy  R. Wedderburn, Paul A. Brogan, Despina Eleftheriou Tags: Original Article Source Type: research

Risk Factors for COVID ‐19 and Rheumatic Disease Flare in a US Cohort of Latino Patients
ConclusionOur findings indicate that Latino patients with rheumatic diseases have a higher rate of COVID-19 compared with the general Latino population. Obesity is a risk factor for COVID-19, and COVID-19 is a risk factor for rheumatic disease flare. Latino patients with risk factors should be closely followed up, especially post –COVID-19 in anticipation of disease flare. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 28, 2021 Category: Rheumatology Authors: Alice Fike, Julia Hartman, Christopher Redmond, Sandra G. Williams, Yanira Ruiz ‐Perdomo, Jun Chu, Sarfaraz Hasni, Michael M. Ward, James D. Katz, Pravitt Gourh Tags: Brief Report Source Type: research

Contribution of a European ‐Prevalent Variant near CD83 and an East Asian–Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome‐Wide Association Study Meta‐Analyses
ObjectiveTofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA), psoriatic arthritis, and ulcerative colitis, and has been previously investigated for psoriasis (PsO). This meta-analysis of genome-wide association studies (GWAS) was performed to identify genetic factors associated with increased risk/faster onset of herpes zoster (HZ) in subjects with RA or PsO receiving tofacitinib treatment, and to determine potential mechanisms that could be attributed to the varying rates of HZ across ethnicities.MethodsIn an ethnicity/indication-specific, trans-ethnic, trans-population meta-analysis of GWA...
Source: Arthritis and Rheumatology - May 28, 2021 Category: Rheumatology Authors: Nan Bing, Huanyu Zhou, Xing Chen, Tomohiro Hirose, Yuta Kochi, Yumi Tsuchida, Kazuyoshi Ishigaki, Shuji Sumitomo, Keishi Fujio, Baohong Zhang, Hernan Valdez, Michael S. Vincent, David Martin, James D. Clark Tags: Original Article Source Type: research

Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology
ConclusionThe findings of the present study indicate a new layer to the molecular complexity of SSc, contributing to a better understanding of the pathogenesis of the disease. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 28, 2021 Category: Rheumatology Authors: Martin Kerick, David Gonz ález‐Serna, Elena Carnero‐Montoro, Maria Teruel, Marialbert Acosta‐Herrera, Zuzanna Makowska, Anne Buttgereit, Sepideh Babaei, Guillermo Barturen, Elena López‐Isac, PRECISESADS Clinical Consortium, Ralf Lesch Tags: Original Article Source Type: research

Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis
This study was undertaken to assess the role of the lymphangiogenic factors vascular endothelial growth factor C (VEGF-C) and angiopoietin 2 (Ang-2) and the soluble forms of their respective cognate receptors, soluble VEGF receptor 3 (sVEGFR-3) and soluble TIE-2, in patients with SSc, and to evaluate their predictive ability as markers for PAH development in SSc.MethodsIn this cohort study, we used multiplex bead assays to assess serum levels of lymphangiogenic factors in 2 well-characterized SSc cohorts: an unselected identification cohort of SSc patients from Oslo University Hospital (n = 371), and a PAH-enriched validat...
Source: Arthritis and Rheumatology - May 28, 2021 Category: Rheumatology Authors: Henriette Didriksen, Øyvind Molberg, Håvard Fretheim, Einar Gude, Suzana Jordan, Cathrine Brunborg, Vyacheslav Palchevskiy, Torhild Garen, Øyvind Midtvedt, Arne K. Andreassen, Oliver Distler, John Belperio, Anna‐Maria Hoffmann‐Vold Tags: Full Length Source Type: research

Mediation of Interleukin ‐23 and Tumor Necrosis Factor–Driven Reactive Arthritis by Chlamydia‐Infected Macrophages in SKG Mice
ConclusionC muridarum load is higher in SKG mice than in BALB/c mice. Whereas proinflammatory IL-23 produced by neutrophils contributes to the initiation ofC muridarum–mediated ReA, macrophage depletion reducesC muridarum dissemination to other tissues, tissue burden, and the development of arthritis. TNF inhibition was also shown to suppress arthritis development. Our data suggest that enhanced bacterial dissemination in macrophages of SKG mice drives the TNF production needed for persistent arthritis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 28, 2021 Category: Rheumatology Authors: Xavier Romand, Xiao Liu, M. Arifur Rahman, Zaied Ahmed Bhuyan, Claire Douillard, Reena Arora Kedia, Nathan Stone, Dominique Roest, Zi Huai Chew, Amy J. Cameron, Linda M. Rehaume, Aur élie Bozon, Mohammed Habib, Charles W. Armitage, Minh Vu Tags: Original Article Source Type: research