Phosphatidic Acid Promoting the Generation of Interleukin ‐17A Producing Double‐Negative T Cells by Enhancing mTORC1 Signaling in Lupus
ConclusionThe accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2024 Category: Rheumatology Authors: Wenjing Li,
Xiaojun Tang,
Yuanyuan Zheng,
Xuefeng Xu,
Nan Zhao,
Betty P. Tsao,
Xuebing Feng,
Lingyun Sun Tags: Full Length Source Type: research
American College of Rheumatology (ACR) and Food and Drug Administration (FDA) Summit: Summary of the Meeting May 17 ‐18, 2022
On May 17-18, 2022, the ACR and the FDA co-sponsored a public meeting to address topics of mutual interest and importance in assessing long-term safety and clinical efficacy, as well as novel approaches to clinical trials in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). During the two-day consensus-building summit, rheumatologists, other health care professionals, and FDA staff provided a broad perspective on current clinical development challenges and potential approaches to address them. Key takeaways are summarized in this document, including issues related to innovative clinical trial designs, use of novel o...
Source: Arthritis and Rheumatology - April 16, 2024 Category: Rheumatology Authors: Jonathan Kay,
Nikolay P. Nikolov,
Michael H. Weisman,
for the
American College of Rheumatology Committee on Research Tags: Special Article Source Type: research
The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti-DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti-DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provok...
Source: Arthritis and Rheumatology - April 16, 2024 Category: Rheumatology Authors: David S. Pisetsky Tags: Review Source Type: research
Incidence of Uveitis in Patients With Axial Spondylarthritis Treated With Biologics or Targeted Synthetics: A Systematic Review and Network Meta ‐Analysis
ConclusionAnti-TNF mAbs, JAKi, and anti –IL-17 appear protective against AU events in individuals with AxSpA, with no significant differences in risk of AU between treatments. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 13, 2024 Category: Rheumatology Authors: Katie Bechman,
Zijing Yang,
Maryam Adas,
Deepak Nagra,
Ali S U ğuzlar,
Mark D. Russell,
Nicky Wilson,
Sophia Steer,
Sam Norton,
James Galloway Tags: Full Length Source Type: research
Standing on Shoulders: Interferon Research From Viral Interference to Lupus Pathogenesis and Treatment
The discovery of interferon in the 1950s represents much more than the identification of the first cytokine and the key mediator of antiviral host defense. Defining the molecular nature and complexity of the type I interferon family, as well as its inducers and molecular mechanisms of action, was the work of investigators working at the highest level and producing insights of great consequence. Current knowledge of receptor –ligand interactions, cell signaling, and transcriptional regulation derives from studies of type I interferon. It is on the shoulders of the giants who produced that knowledge that others stand and h...
Source: Arthritis and Rheumatology - April 12, 2024 Category: Rheumatology Authors: Mary K. Crow,
Mikhail Olferiev,
Kyriakos A. Kirou Tags: Review Source Type: research
Risk of Relapse of Antineutrophil Cytoplasmic Antibody –Associated Vasculitis in a Randomized Controlled Trial of Plasma Exchange and Glucocorticoids
ConclusionIn patients with severe ANCA-associated vasculitis, relapses remain common; neither the use of PLEX nor an initial glucocorticoid tapering regimen impacted relapse risk. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 9, 2024 Category: Rheumatology Authors: Mats L. Junek,
Peter A. Merkel,
Eswari Vilayur,
Ron Wald,
Nader Khalidi,
David Jayne,
Michael Walsh,
for the PEXIVAS Investigators,
Kathy Paizis,
Donna Reidlinger,
Alicia Morrish,
Sunil V Badve,
Elaine Pascoe,
Peta ‐Anne Paul‐Brent,
Laur Tags: Brief Report Source Type: research
EphB2 receptor promotes dermal fibrosis in systemic sclerosis
ConclusionOur data implicate TGF- β regulation of EphB2 overexpression and kinase-mediated forward signaling in the development of dermal fibrosis in SSc. EphB2 thus represents a potential new therapeutic target for SSc. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 9, 2024 Category: Rheumatology Authors: Erika SA Egal,
Severin Donald Kamdem,
Masaaki Yoshigi,
Ching ‐Chu Yang,
Sarah Pellizzari,
Ernest M Kameni,
My N Helms,
Shervin Assassi,
Mark Henkemeyer,
Tracy M Frech,
Patrice N Mimche Tags: Full Length Source Type: research
A GITRL ‐mTORC1‐GM‐CSF positive loop promotes pathogenic Th17 response in exacerbating Primary Sjögren's Syndrome
ConclusionsOur results identified the pathogenic role of GITRL in exacerbating disease activity and promoting pathogenic Th17 response in pSS through a GITRL/mTORC1/GM-CSF positive loop. These findings suggest GITRL might be a promising therapeutic target in the treatment of pSS. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 9, 2024 Category: Rheumatology Authors: Yuzhou Gan,
Haotian Zhou,
Yixue Guo,
Bo Huang,
Hongjiang Liu,
Ziye Wang,
Zijun Li,
Xiaozhen Zhao,
Huaqun Zhu,
Qimao Han,
Hua Ye,
Jing He,
Qingwen Wang,
Zhanguo Li,
Xiaolin Sun Tags: Full Length Source Type: research
