Clinical Images: Wong ‐type dermatomyositis in an African American patient
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 17, 2021 Category: Rheumatology Authors: Christina E. Bax, Madison Grinnell, Josef Symon S. Concha, Victoria P. Werth Tags: Clinical Image Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 17, 2021 Category: Rheumatology Authors: Laure Delaval, Benjamin Terrier Tags: Letters Source Type: research

Interleukin ‐7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjögren’s Syndrome
ConclusionThese results suggest the presence of an IL ‐7/IFNγ amplification loop involving SGECs and T cells in primary SS. IL‐7 was secreted by SGECs stimulated with type I or type II IFN and, in turn, activated T cells that secrete type II IFN. An anti–IL‐7R antibody decreased the IFN signature in T cells in primary SS and could be of therap eutic interest. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 16, 2021 Category: Rheumatology Authors: Elodie Rivi ère, Juliette Pascaud, Alexandre Virone, Anastasia Dupré, Bineta Ly, Audrey Paoletti, Raphaèle Seror, Nicolas Tchitchek, Michael Mingueneau, Nikaïa Smith, Darragh Duffy, Lydie Cassard, Nathalie Chaput, Sabrina Pengam, Vanessa Tags: Full Length Source Type: research

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS –CoV‐2 and Hyperinflammation in Pediatric COVID‐19: Version 2
ConclusionOur understanding of SARS –CoV‐2–related syndromes in the pediatric population continues to evolve. This guidance document reflects currently available evidence coupled with expert opinion, and will be revised as further evidence becomes available. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 16, 2021 Category: Rheumatology Authors: Lauren A. Henderson, Scott W. Canna, Kevin G. Friedman, Mark Gorelik, Sivia K. Lapidus, Hamid Bassiri, Edward M. Behrens, Anne Ferris, Kate F. Kernan, Grant S. Schulert, Philip Seo, Mary Beth F. Son, Adriana H. Tremoulet, Rae S. M. Yeung, Am Tags: Full Length Source Type: research

A Novel RELA Truncating Mutation in a Familial Beh çet’s Disease–like Mucocutaneous Ulcerative Condition
ConclusionOur data indicate that RELA loss ‐of‐function mutations cause BD‐like autoinflammation and NMO via impaired NF‐κB signaling and increased apoptosis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: Fahd Adeeb, Emma R. Dorris, Niamh E. Morgan, Dylan Lawless, Aqeel Maqsood, Wan Lin Ng, Orla Killeen, Eoin P. Cummins, Cormac T. Taylor, Sinisa Savic, Anthony G. Wilson, Alexander Fraser Tags: Brief Report Source Type: research

Epicardial adipose tissue volume is a marker of subclinical coronary atherosclerosis in Rheumatoid arthritis
ABSTRACTObjectivesTo assess epicardial adipose tissue volume (EATv) and its link to coronary atherosclerosis and plaque morphology in patients with rheumatoid arthritis (RA) and age ‐ and gender‐matched controls.MethodsComputed tomography angiography evaluated EATv and coronary plaque in 139 RA patients and 139 non ‐RA controls. All models assessing the effect of EATv on plaque adjusted for age, gender, hypertension, diabetes, dyslipidemia, smoking, family history of coronary artery disease, and obesity (body mass index≥30 kg/m2).ResultsMean ( ±standard deviation [SD]) log‐transformed EATv was similar in ...
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: George A Karpouzas, Panteha Rezaeian, Sarah R Ormseth, Ivana Hollan, Matthew J Budoff Tags: FULL LENGTH Source Type: research

Giant iliopsoas bursitis in systemic juvenile idiopathic arthritis
AbstractA 4 ‐year‐old boy with systemic juvenile idiopathic arthritis (sJIA) relapsed while on tacrolimus and tocilizumab (TCZ). He presented with right groin pain and claudication. The patient had mild tenderness and restricted range of motion in his right hip joint on physical examination. Furthermore, no mass was palpable. Laboratory findings revealed a highly elevated level of serum matrix metalloproteinase‐3 (MMP‐3; 551 ng/dL). (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: Asami Shimbo, Yuko Akutsu, Susumu Yamazaki, Masaki Shimizu, Masaaki Mori Tags: CLINICAL IMAGE Source Type: research

Genome ‐wide reduction in chromatin accessibility and unique transcription factor footprints in endothelial cells and fibroblasts in scleroderma skin
ConclusionOur data uncovered the chromatin blueprint of dcSSc, and suggested that neuronal ‐related characteristics of SSc ECs and fibroblasts could be a culprit for dysregulated angiogenesis and enhanced fibrosis. Targeting key pathways and transcription factors identified might present novel therapeutic approaches in SSc. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: Pei ‐Suen Tsou, Pamela J. Palisoc, Mustafa Ali, Dinesh Khanna, Amr H Sawalha Tags: FULL LENGTH Source Type: research

Elevated urate does not alter bone turnover markers. Randomized controlled trial of inosine supplementation in post ‐menopausal women
AbstractObjectiveObservational studies have consistently reported that serum urate positively correlates with bone mineral density (BMD). The aim of this study was to determine whether moderate hyperuricaemia induced by inosine supplements influences bone turnover markers in post ‐menopausal women over a six‐month period.MethodsOne hundred and twenty post ‐menopausal women were recruited into a six‐month randomised, double‐blind, placebo‐controlled trial. Key exclusion criteria were osteoporosis, previous fragility fracture, bisphosphonate therapy, gout, kidney stones, and urine pH ≤5.0. Participants were ra...
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: Nicola Dalbeth, Anne Horne, Borislav Mihov, Angela Stewart, Gregory D Gamble, Tony R Merriman, Lisa K Stamp, Ian R Reid Tags: FULL LENGTH Source Type: research

Reply to Prophylactic Anticoagulation: Comment on the ACR Guidance for Management of Multisystem Inflammatory Syndrome in Children
AbstractWe thank Dr. Kotnik and colleagues for their commentary on the American College of Rheumatology ’s clinical guidance for pediatric patients with multisystem inflammatory syndrome in children (MIS‐C). The use of anticoagulation in this population remains an intensely debated topic with little clinical evidence to guide treatment decisions. For this reason, the task force was only able to ac hieve consensus on recommending anticoagulation in patients with larger coronary artery aneurysms (CAAs) (z‐score>10) and significant cardiac dysfunction (ejection fraction
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: Lauren A. Henderson, Kevin G. Friedman, Kate F. Kernan, Scott W. Canna, Mark Gorelik, Sivia K. Lapidus, Hamid Bassiri, Edward M. Behrens, Anne Ferris, Grant S. Schulert, Philip Seo, Mary Beth F. Son, Adriana H. Tremoulet, Rae S.M Yeung, Davi Tags: REPLY Source Type: research

Prophylactic anticoagulation: comment on the American College of Rheumatology Guidance for Management of Multisystem Inflammatory Syndrome in Children
AbstractThe American College of Rheumatology guidance for management of pediatric patients with multisystem inflammatory syndrome in children (MIS ‐C) associated with SARS‐CoV‐2 have been recently published. The guidance was prepared by the multidisciplinary Task Force and provide a very rational approach to management of this condition. There is, however, one area in which we are in disagreement. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: Barbara Faganel Kotnik, Mojca Zajc Avramovi č, Lidija Kitanovski, Tadej Avčin Tags: LETTER TO THE EDITOR Source Type: research

TRPV2 is involved in induction of lubricin and suppression of ectopic endochondral ossification in articular joints
ConclusionThis study shows regulation of articular cartilage by TRPV2 through Prg4 induction and suppression of ectopic ossification. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 15, 2021 Category: Rheumatology Authors: Hideki Nakamoto, Yuki Katanosaka, Ryota Chijimatsu, Daisuke Mori, Fengjun Xuan, Fumiko Yano, Yasunori Omata, Yuji Maenohara, Yasutaka Murahashi, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi, Yuki Taniguchi, Motoi Kanagawa, Tags: FULL LENGTH Source Type: research

A Picture is Worth A Thousand Words, but Only if it is a Good Picture
AbstractEdward Tufte, considered by some as the Leonardo Da Vinci of scientific illustrations, described that, “Excellence in statistical graphics consists of complex ideas communicated with clarity, precision, and efficiency. Graphical display should: show the data, … make large data sets coherent, encourage the eye to compare different pieces of data, … and be closely integrated with the statistical and verbal descriptions of a data set.”(1) While Tufte wrote this in 2001, before many of the current analytic technologies were developed, the concepts still apply. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2021 Category: Rheumatology Authors: Daniel H. Solomon, Bryce A. Binstadt, David T. Felson, Peter A. Nigrovic Tags: EDITORIAL Source Type: research

Outcomes of a Mobile App to Monitor Patient Reported Outcomes in Rheumatoid Arthritis: A Randomized Controlled Trial
ConclusionsA mobile app designed to collect ePRO data on RA symptoms did not significantly improve patient satisfaction or disease activity compared to care coordination alone. However, both patients and physicians reported positive experiences with the app. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: Yvonne C. Lee, Fengxin Lu, Joshua Colls, Dee Luo, Penny Wang, Dorothy D. Dunlop, Lutfiyya N. Muhammad, Jing Song, Kaleb Michaud, Daniel H. Solomon Tags: FULL LENGTH Source Type: research

Sj ögren’s disease, not syndrome
AbstractSj ögren’s syndrome should henceforth be known as Sjögren’s disease. Our call for this is based on the precedence for such name changes in rheumatology as well as important differences between syndrome and disease. In addition, the struggle faced by Sjögren’s patients to gain recognition for t his serious autoimmune disease is difficult when some describe it as a collection of nuisance symptoms. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: Alan N. Baer, Katherine M. Hammitt Tags: LETTER TO THE EDITOR Source Type: research

ROR γt licenses the differentiation and function of a unique subset of Tfh cells in response to immunogenic self‐DNA in systemic lupus erythematosus
ConclusionImmunogenic self ‐DNA instructs ICOS‐dispensable IL‐17+Tfh cells via ROR γt for IgG anti‐dsDNA response, serving as promising therapeutic targets for lupus patients. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: Zhenke Wen, Lin Xu, Wei Xu, Sidong Xiong Tags: FULL LENGTH Source Type: research

ACR, AAD, RDS, and AAO 2020 Joint Statement on Hydroxychloroquine Use with Respect to Retinal Toxicity
AbstractPrescribing clinicians and eye care specialists share responsibility for safely prescribing hydroxychloroquine (HCQ) and screening for the potential risk of retinopathy. Two relevant national societies, the American College of Rheumatology (ACR) and the American Academy of Ophthalmology (AAO), have independently offered management guidelines (1, 2), but this is the first joint statement to emphasize points of agreement that should be recognized by practitioners in all specialties. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: James T. Rosenbaum, Karen H. Costenbader, Julianna Desmarais, Ellen M. Ginzler, Nicole Fett, Susan M. Goodman, James R. O ’Dell, Gabriela Schmajuk, Victoria P. Werth, Ronald B. Melles, Michael F. Marmor Tags: SPECIAL ARTICLE Source Type: research

Camptothecin and topotecan, inhibitors of transcription factor Fli ‐1 and topoisomerase, markedly ameliorate lupus nephritis in NZBWF1 mice and reduce the production of inflammatory mediators in human renal cells
ConclusionThe results indicate that low dose CPT and TPT could be repurposed to treat lupus nephritis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: Xuan Wang, Jim C. Oates, Kristi L. Helke, Gary S. Gilkeson, Xian K. Zhang Tags: FULL LENGTH Source Type: research

Aim2 Couples with Ube2i for Sumoylation ‐mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus
ConclusionThis study demonstrates a critical role for Aim2 in an optimal Ube2i ‐mediated sumoylation‐based suppression of IFN‐I generation and development of SLE, the Aim2‐Ube2i axis can thus be a novel target for intervention. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: Ailing Lu, Shuxian Wu, Junling Niu, Mengmeng Cui, Mengdan Chen, William L. Clapp, Betsy J. Barnes, Guangxun Meng Tags: FULL LENGTH Source Type: research

The TNFRSF11B mutation associated with calcium pyrophosphate deposition disease results in ineffective osteoclast suppression
ConclusionsWe show here that OPG ‐XL is a loss‐of‐function mutation as it relates to RANKL‐mediated osteoclastogenesis and thus may permit increased OC number and heightened bone turnover. Further studies will be necessary to demonstrate how this mutation contributes to arthritis in individuals carrying this mutation. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: Elizabeth Mitton ‐Fitzgerald, Claudia M. Gohr, Charlene J Williams, Amaryllis Ortiz, Gabriel Mbalaviele, Ann K. Rosenthal Tags: BRIEF REPORT Source Type: research

Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma
ObjectiveIntravenous iloprost improves Raynaud ’s phenomenon (RP) and promotes healing of digital ulcers in systemic sclerosis (SSc; scleroderma). Despite a short half‐life, its clinical efficacy lasts weeks. Endothelial adherens junctions, which are formed by VE‐cadherin clustering between endothelial cells (ECs), regulate endothelial pro perties including barrier function, endothelial‐to‐mesenchymal transition (EndoMT), and angiogenesis. We undertook this study to investigate the hypothesis that junctional disruption contributes to vascular dysfunction in SSc, and that the protective effect of iloprost is m...
Source: Arthritis and Rheumatology - February 8, 2021 Category: Rheumatology Authors: Pei ‐Suen Tsou, Pamela J. Palisoc, Nicholas A. Flavahan, Dinesh Khanna Tags: Full Length Source Type: research

LBP and CD14, cofactors of toll ‐like receptors, are essential for low‐grade inflammation‐induced exacerbation of post‐traumatic osteoarthritis
ConclusionLBP and CD14, which are accessory molecules of TLRs, are necessary for the exacerbation of post ‐traumatic OA cartilage destruction caused by low‐grade inflammation, such as that triggered by HFD or endotoxemia. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 8, 2021 Category: Rheumatology Authors: Yoonkyung Won, Jeong ‐In Yang, Seulki Park, Jang‐Soo Chun Tags: FULL LENGTH Source Type: research

TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis: a longitudinal analysis from the ALBERTA FORCAST cohort
ConclusionTNFi reduce spinal radiographic progression in patients with radiographic axSpA which might be partially uncoupled from their effects on ASDAS inflammation. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: Alexandre Sepriano, Sofia Ramiro, Stephanie Wichuk, Praveena Chiowchanwisawakit, Joel Paschke, D ésirée van der Heijde, Robert Landewé, Walter P. Maksymowych Tags: FULL LENGTH Source Type: research

Tocilizumab Prevents Progression of Early Systemic Sclerosis Associated Interstitial Lung Disease
ConclusionTocilizumab in early SSc ‐ associated interstitial lung disease with progressive skin disease stabilized forced vital capacity over 48 weeks, independent of the extent of quantitative radiographic interstitial lung disease or fibrosis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: David Roofeh, Celia J F Lin, Jonathan Goldin, Grace Hyun Kim, Daniel E Furst, Christopher P Denton, Suiyuan Huang, Dinesh Khanna, The focuSSced investigators Tags: FULL LENGTH Source Type: research

Could compensatory autoantibody production affect RA etiopathogenesis?
AbstractThe report from El ‐Gabalawy and coworkers represents an important chapter in their studies of rheumatoid arthritis (RA) in a unique First Nation (FN) patient cohort and their at‐risk first‐degree relatives (FDR)(1). These members of the Cree and Chippewa tribes in rural Manitoba Canada share racial/ethnic (and presumed genetic) features distinct from other RA cohorts. Here, the investigators show that during the preclinical phase, when patients were asymptomatic, these FN FDR express serum RA disease‐associated anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies and rh eu...
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: Gregg J. Silverman Tags: EDITORIAL Source Type: research

Expansion of alternative autoantibodies does not follow the evolution of anti ‐citrullinated protein antibodies in preclinical rheumatoid arthritis ‐ An analysis in at‐risk first‐degree relatives
ConclusionWhile alternative autoimmunity and ANA positivity is widely prevalent in FN population, including asymptomatic, seronegative FDR, expansion of alternative autoimmunity in FDR does not occur in parallel to ACPA expansion and is restricted to established RA patients. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Liam O ’Neil, Mackenzie A. Jantz, Marvin J. Fritzler, Hani El‐Gabalawy Tags: FULL LENGTH Source Type: research

Specific T follicular helper signature in Takayasu Arteritis
ConclusionsWe established a specific Tfh signature in in both circulating and aorta infiltrating CD4+ T cells of TA patients. Tfh and B cells cooperation might be critical in the occurrence of vascular inflammation in TA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: AC. Desbois, P. R égnier, V. Quiniou, A. Lejoncour, A. Maciejewski‐Duval, C. Comarmond, H. Vallet, M. Rosenzwag, G. Darrasse‐Jèze, N. Derian, J Pouchot, M Samson, B Bienvenu, P. Fouret, F. Koskas, M Garrido, D. Sène, P. Bruneval, Tags: FULL LENGTH Source Type: research

Long ‐Term Outcomes in Patients with Connective Tissue Disease‐Associated Pulmonary Arterial Hypertension in the Modern Treatment Era: Meta‐Analyses of Randomized, Controlled Trials and Observational Registries
AbstractObjectiveData on the magnitude of benefit of modern pulmonary arterial hypertension (PAH) therapies in connective tissue disease ‐associated PAH (CTD‐PAH) are limited. We performed meta‐analyses of randomized, controlled trials (RCTs) and registries to quantify this benefit (PROSPERO# CRD42020167119).MethodsPubMed and EMBASE were searched for articles reporting data from RCTs or registries published 1/1/2000 –11/25/2019. Eligibility criteria included multicenter studies with ≥30 CTD‐PAH patients. RCTs had to evaluate approved PAH therapy and report long‐term clinical morbidity/mortality or 6‐mi...
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: Dinesh Khanna, Carol Zhao, Rajan Saggar, Stephen C. Mathai, Lorinda S. Chung, J. Gerry Coghlan, Mehul Shah, John Hartney, Vallerie McLaughlin Tags: FULL LENGTH Source Type: research

New Therapeutic Targets in Antineutrophil Cytoplasm Antibody –Associated Vasculitis
Antineutrophil cytoplasm antibody (ANCA) –associated vasculitis (AAV) is a rare systemic autoimmune disease that is characterized by necrotizing inflammation of predominantly the small blood vessels and the presence of circulating ANCAs directed against myeloperoxidase or proteinase 3. Current treatment strategies for severe disease, sup ported by the findings of several well‐coordinated randomized controlled trials, aim to induce remission with high‐dose glucocorticoids and either rituximab or cyclophosphamide, followed by relapse prevention with a period of sustained low‐dose treatment. This approach has dram...
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: Maria Prendecki, Stephen P. McAdoo Tags: Review Source Type: research

Combining datasets as well as therapies shows improved outcome in connective tissue disease associated pulmonary hypertension
AbstractThe article of Khanna et al [1] is an important summary of more than two decades of progress in management of connective tissue disease (CTD) associated pulmonary hypertension (PH) that provides an important platform for further advances. It also clearly shows the positive impact of current practice with combination therapy introduced early and an emphasis on proactive screening to make an early diagnosis of PH. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 4, 2021 Category: Rheumatology Authors: Christopher P. Denton, Julia Spierings Tags: EDITORIAL Source Type: research

Allele ‐Specific Quantification of HLA–DRB1 Transcripts Reveals Imbalanced Allelic Expression That Modifies the Amino Acid Effects in HLA–DRβ1
ConclusionOur findings illustrate the advantage of integrating quantitative and qualitative changes in HLA –DRB1 into a single model for understanding HLA–DRB1 associations. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 3, 2021 Category: Rheumatology Authors: Sehwan Chun, So ‐Young Bang, Eunji Ha, Jing Cui, Ki‐Nam Gu, Hye‐Soon Lee, Kwangwoo Kim, Sang‐Cheol Bae Tags: Full Length Source Type: research

Long ‐Term Safety and Efficacy of Subcutaneous Tanezumab Versus Nonsteroidal Antiinflammatory Drugs for Hip or Knee Osteoarthritis: A Randomized Trial
AbstractObjectiveAssessment of long ‐term safety and 16‐week efficacy of subcutaneous tanezumab in patients with hip or knee OA.MethodsThis was a randomized, double ‐blind, double‐dummy, active‐controlled (nonsteroidal antiinflammatory drug [NSAID]), phase III safety trial (56‐week treatment/24‐week post‐treatment follow‐up) in adults receiving stable dose NSAID therapy at the time of screening and WOMAC1 Pain and Physical Function scores ≥5; patient’s global assessment of osteoarthritis (PGA‐OA; “fair,” “poor,” or “very poor”); history of inadequate pain rel...
Source: Arthritis and Rheumatology - February 3, 2021 Category: Rheumatology Authors: Marc C. Hochberg, John A. Carrino, Thomas J. Schnitzer, Ali Guermazi, David A Walsh, Alexander White, Satoru Nakajo, Robert J. Fountaine, Anne Hickman, Glenn Pixton, Lars Viktrup, Mark T. Brown, Christine R. West, Kenneth M. Verburg Tags: FULL LENGTH Source Type: research

Association of Race and Ethnicity With COVID ‐19 Outcomes in Rheumatic Disease: Data From the COVID‐19 Global Rheumatology Alliance Physician Registry
ConclusionSimilar to findings in the general US population, racial/ethnic minorities with rheumatic disease and COVID ‐19 had increased odds of hospitalization and ventilatory support. These results illustrate significant health disparities related to COVID‐19 in people with rheumatic diseases. The rheumatology community should proactively address the needs of patients currently experiencing inequitable health outcomes during the pandemic. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 2, 2021 Category: Rheumatology Authors: Milena A. Gianfrancesco, Liza A. Leykina, Zara Izadi, Tiffany Taylor, Jeffrey A. Sparks, Carly Harrison, Laura Trupin, Stephanie Rush, Gabriela Schmajuk, Patricia Katz, Lindsay Jacobsohn, Tiffany Y. Hsu, Kristin M. D ’Silva, Naomi Serling Tags: Full Length Source Type: research

Suppression of Serum Interferon ‐γ Levels as a Potential Measure of Response to Ustekinumab Treatment in Patients With Systemic Lupus Erythematosus
ObjectiveIn a previously reported phase II randomized, placebo ‐controlled, interventional trial, we demonstrated that treatment with ustekinumab, an anti–interleukin‐12 (IL‐12)/IL‐23 p40 neutralizing monoclonal antibody, improved global and organ‐specific measures of disease activity in patients with active systemic lupus erythematosus (SLE). Utili zing the biomarker data from this phase II clinical study, we sought to determine whether modulation of the expression of IL‐12, IL‐23, or both cytokines by ustekinumab is associated with clinical efficacy in patients with SLE.MethodsThis phase II randomized...
Source: Arthritis and Rheumatology - February 1, 2021 Category: Rheumatology Authors: Matteo Cesaroni, Loqmane Seridi, Matthew J. Loza, Jessica Schreiter, Kristen Sweet, Carol Franks, Keying Ma, Ashley Orillion, Kim Campbell, Robert M. Gordon, Patrick Branigan, Peter Lipsky, Ronald Vollenhoven, Bevra H. Hahn, George C. Tsokos Tags: Brief Report Source Type: research

Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor β Signaling
This study was conducted to determine the osteocytic contributions of TGFβ signaling to OA.MethodsTo identify the role of osteocytic TGF β signaling in joint homeostasis, we used 16‐week‐old male mice (n = 9–11 per group) and female mice (n = 7–11 per group) with an osteocyte‐intrinsic ablation of TGFβ receptor type II (TβRIIocy −/− mice) and assessed defects in cartilage degeneration, subchondral bone plate (SBP) thickness, and SBP sclerostin expression. To further investigate these mechanisms in 16 ‐week‐old male mice, we perturbed joint homeostasis by subjecting 8‐...
Source: Arthritis and Rheumatology - February 1, 2021 Category: Rheumatology Authors: Karsyn N. Bailey, Jeffrey Nguyen, Cristal S. Yee, Neha S. Dole, Alexis Dang, Tamara Alliston Tags: Full Length Source Type: research

Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis
ConclusionOxylipin networks differ across stages during the earliest phases of RA. These distinct oxylipin networks could potentially elucidate pathways with clinical relevance for disease progression, clinical heterogeneity, and treatment response. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Javier Rodr íguez-Carrio, Roxana Coras, Mercedes Alperi-López, Patricia López, Catalina Ulloa, Francisco Javier Ballina-García, Aaron M. Armando, Oswald Quehenberger, Mónica Guma, Ana Suárez Tags: Full Length Source Type: research

Further investigation of representation of women as authors of rheumatology articles from 2005 to 2020: comment on the article by Bagga et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Jennifer Velasco, Shikha Singla, Michael Putman, Abigail A. Thorgerson, Elizabeth Suelzer, Courtney B. Crayne Tags: Letters Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Iris Navarro-Mill án, Mary K. Crow Tags: Letters Source Type: research

Use of apremilast in patients with psoriatic arthritis during the COVID ‐19 pandemic: comment on the article by Mikuls et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Pankaj Bansal, Amandeep Goyal, Austin Cusick, Fawad Aslam Tags: Letters Source Type: research

Anakinra in COVID ‐19—how to interpret elevations of serum liver enzymes: comment on the article by Navarro‐Millàn et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Giulio Cavalli, Lorenzo Dagna Tags: Letters Source Type: research

Type 1 Interferon –Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
ConclusionWe identified a role for type I IFN signaling in driving STAT4 activation and production of IL ‐21 and IFNγ by Tfh cells in murine and human lupus. Enhanced STAT4 activation in Tfh cells may underlie pathogenic B cell responses in both murine and human lupus. These data indicate that STAT4 guides pathogenic cytokine and immunoglobulin production in SLE, demonstrating a potential therapeuti c target to modulate autoimmunity. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Xuemei Dong, Olivia Q. Antao, Wenzhi Song, Gina M. Sanchez, Krzysztof Zembrzuski, Fotios Koumpouras, Alexander Lemenze, Joe Craft, Jason S. Weinstein Tags: Full Length Source Type: research

Characterization and Function of Tumor Necrosis Factor alpha and Interleukin ‐6‐Induced Osteoclasts in Rheumatoid Arthritis
ConclusionOur results demonstrate that TNF α and IL‐6‐induced osteoclasts may contribute to the pathology of inflammatory arthritis associated with joint destruction, such as RA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Kazuhiro Yokota, Kojiro Sato, Takashi Miyazaki, Yoshimi Aizaki, Shinya Tanaka, Miyoko Sekikawa, Noritsune Kozu, Yuho Kadono, Hiromi Oda, Toshihide Mimura Tags: FULL LENGTH Source Type: research

COVID ‐19 Reinfection in a Patient Receiving Immunosuppression for ANCA‐associated Vasculitis
AbstractA 61 ‐year‐old South Asian woman presented in early April 2020, during the first peak of the COVID‐19 pandemic, with acute onset dry cough, dyspnea, fever, and myalgia. Initial laboratory tests were suggestive of COVID‐19 (neutrophil:lymphocyte ratio 10.3, platelets 517x109/L, CRP 236mg/L, D ‐dimer 5794µg/L, ferritin 528µg/L, troponin 881ng/L), and infection was confirmed by SARS‐CoV‐2 PCR testing of a nasopharyngeal swab. She received supportive care for COVID‐19 and had gradual resolution of fever and myalgia over the following 14 days. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2021 Category: Rheumatology Authors: Kavita Gulati, Maria Prendecki, Candice Clarke, Michelle Willicombe, Stephen McAdoo Tags: LETTER TO THE EDITOR Source Type: research

Treat ‐to‐target in gout management? Comment on the article by FitzGerald et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 28, 2021 Category: Rheumatology Authors: Michael R. Kolber, Joey Ton Tags: Letters Source Type: research

Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 28, 2021 Category: Rheumatology Authors: Tuhina Neogi, Nicola Dalbeth, Ted R. Mikuls, Amy S. Turner, John D. FitzGerald Tags: Letters Source Type: research

Trends in utilization of urate ‐lowering therapies following the US Food and Drug Administration’s boxed warning on febuxostat
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 28, 2021 Category: Rheumatology Authors: Seoyoung C. Kim, Tuhina Neogi, Erin Kim, Joyce Lii, Rishi J. Desai Tags: Letters Source Type: research

Spondylitis as a Rare Manifestation of Granulomatosis With Polyangiitis
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 28, 2021 Category: Rheumatology Authors: Matthias H. Busch, Joop P. Aendekerk, Astrid M. L. Oude Lashof, Pieter Paassen Tags: Clinical Image Source Type: research

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(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 27, 2021 Category: Rheumatology Tags: Clinical Connections Source Type: research

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(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 27, 2021 Category: Rheumatology Tags: Issue Information Source Type: research

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(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 27, 2021 Category: Rheumatology Tags: Journal Club Source Type: research