Association of autoantibody quantification with systemic lupus erythematosus disease activity: comment on the article by Kim et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 19, 2019 Category: Rheumatology Authors: Xiaojun Tang, Mingzhe Ning, Yantong Zhu, Yun Zhu, Yang Xu, Si Wu, Xuebing Feng Tags: Letters Source Type: research

Could the levels of inflammatory biomarkers predict osteoarthritis? Comment on the article by Roemer et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 19, 2019 Category: Rheumatology Authors: Zhen ‐Han Deng, Chao Cheng, Jian Tian, Fang‐Jie Zhang Tags: Letters Source Type: research

The limitation and racial difference of the plasma microbiome in SLE disease
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 17, 2019 Category: Rheumatology Authors: Elizabeth Ogunrinde, Zejun Zhou, Gary Gilkeson, Wei Jiang Tags: Reply To Letter To The Editor Source Type: research

Randomized, Double ‐Blind, Placebo‐Controlled Trial of Intraarticular Trans‐Capsaicin for Pain Associated With Osteoarthritis of the Knee
ObjectiveTo assess the efficacy and safety of high ‐purity synthetic trans‐capsaicin (CNTX‐4975) in patients with chronic moderate‐to‐severe osteoarthritis (OA)–associated knee pain.MethodsIn this phase II multicenter double ‐blind study, patients ages 45–80 years who had stable knee OA were randomized in a 2:1:2 ratio to receive a single intraarticular injection of placebo, CNTX‐4975 0.5 mg, or CNTX‐4975 1.0 mg. The primary efficacy end point was area under the curve (AUC) for change from baseline in daily West ern Ontario and McMaster Universities Osteoarthritis Index pain with walking score (...
Source: Arthritis and Rheumatology - July 17, 2019 Category: Rheumatology Authors: Randall M. Stevens, John Ervin, Jennifer Nezzer, Yeni Nieves, Kimberly Guedes, Robin Burges, Peter D. Hanson, James N. Campbell Tags: Original Article Source Type: research

Bone marrow edema and ankylosis of the sacroiliac joints: Spondyloarthritis, they said
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 17, 2019 Category: Rheumatology Authors: Frank Verhoeven, Maxime Sondag, Cl ément Prati, Daniel Wendling Tags: Clinical Image Source Type: research

Neutrophil extracellular trap formation is intrinsically distinct in ANCA ‐associated vasculitis and systemic lupus erythematosus
AbstractObjectivesDifferent studies have demonstrated that neutrophil extracellular traps (NETs) may be involved in the pathophysiology of both ANCA ‐associated vasculitis (AAV) and systemic lupus erythematosus (SLE). AAV and SLE are clinically and pathologically divergent autoimmune diseases with different autoantibodies. However, the respective autoantigens recognized in AAV and SLE have been shown to be an intricate part of NETs. Therefore, we hypothesized that the mechanisms of NET formation and the composition of NETs might be distinct between AAV and SLE.MethodsTo investigate this hypothesis, we directly compared A...
Source: Arthritis and Rheumatology - July 16, 2019 Category: Rheumatology Authors: Laura S. van Dam, Tineke Kraaij, Sylvia W. A Kamerling, Jaap A. Bakker, Uli H. Scherer, Ton J. Rabelink, Cees van Kooten, Y.K. Onno Teng Tags: Full Length Source Type: research

Toward Accelerated Authorization and Access to New Medicines for Juvenile Idiopathic Arthritis
ConclusionEnsuring new medicines are authorized in a timely manner to meet the needs of JIA patients worldwide is critical. Approaches should include: open dialogue between regulatory agencies, pharmaceutical companies and other stakeholders to develop and implement novel study designs; including patient and clinician perspectives to define meaningful trial outcomes; and changing existing study plans.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 16, 2019 Category: Rheumatology Authors: Laura E. Schanberg, Athimalaipet V Ramanan, Fabrizio De Benedetti, Timothy Beukelman, Guy S. Eakin, Vincent Del Gaizo, Sarah Ringold, Richard Vesely, Suzanne Schrandt, Thomas Jaki, Androniki Bili, James B. Chung, Stephanie De Bono, Wendy Doug Tags: Full Length Source Type: research

There may be other explanations for the confusing finding in the divergence in the results between first ‐degree relatives and SLE patients
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 16, 2019 Category: Rheumatology Authors: Zaixing Yang, Yan Liang Tags: Letter to the Editor Source Type: research

MRI Lesions in the Sacroiliac Joints for Differentiation of Patients with Axial Spondyloarthritis from Postpartum Women, Patients with Disc Herniation, Cleaning Staff, Long Distance Runners and Healthy Persons ‐ A Prospective Cross‐sectional Study of 204 Participants
ConclusionsBME and fat lesions were most pronounced in axSpA, but also occurred in other groups, particularly women with postpartum pain. Erosion above a certain threshold, backfill and ankylosis were highly specific for axSpA.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 16, 2019 Category: Rheumatology Authors: Seng ül Seven, Mikkel Østergaard, Lone Morsel‐Carlsen, Inge Juul Sørensen, Birthe Bonde, Gorm Thamsborg, Jens Jørgen Lykkegaard, Oliver Hendricks, Niklas Rye Jørgensen, Susanne Juhl Pedersen Tags: Full Length Source Type: research

What level of inflammation leads to structural damage in the sacroiliac joints?
ConclusionsWhileextensiveSIJ BMO was a strong independent predictor for development of structural lesions,limited/intermediateBMO were mostly transient and only rarely evolved intoextensiveBMO or structural lesions. These findings enhance our understanding of the natural development of SIJ lesions and indicate different progression patterns forlimited/intermediate vs.extensiveBMO, possibly due to different aetiologies.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 16, 2019 Category: Rheumatology Authors: Bodil Arnbak, Tue S. Jensen, Berit Schi øttz‐Christensen, Susanne J. Pedersen, Mikkel Østergaard, Ulrich Weber, Oliver Hendricks, Anna Zejden, Claus Manniche, Anne G. Jurik Tags: Full Length Source Type: research

Clinical Applicability of Ultrasound in Systemic Large Vessel Vasculitides
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 16, 2019 Category: Rheumatology Authors: Alen Brkic, Lene Terslev, Uffe M øller Døhn, Søren Torp‐Pedersen, Wolfgang A Schmidt, Andreas P Diamantopoulos Tags: Review Article Source Type: research

MicroRNA ‐125b Regulates Fibroblast Apoptosis Proliferation in Systemic Sclerosis
AbstractObjectiveThe aim of the study was to analyze the expression, regulation and role of microRNA ‐125b (miR‐125b) in systemic sclerosis (SSc).MethodsMiR ‐125b expression was assessed by qPCR on RNA from dermal fibroblasts and whole skin biopsies of healthy controls (HC) and SSc patients. To identify downstream effectors, RNA from HC fibroblasts after miR‐125b knockdown was sequenced and further validated using qPCR and Western blot. Fibrosis, ap optosis and proliferation were assessed by Caspase‐Glo 3/7 assay, Western blot, immunofluorescence for cleaved caspase 3 and Annexin V live assay in dermal fibroblast...
Source: Arthritis and Rheumatology - July 16, 2019 Category: Rheumatology Authors: Anastasiia Kozlova, Elena Pachera, Britta Maurer, Astrid J üngel, Jörg H.W. Distler, Gabriela Kania, Oliver Distler Tags: Full Length Source Type: research

Human cartilage homogenates influence the crystallization of monosodium urate (MSU) and the inflammatory response to MSU crystals: a potential link between osteoarthritis and gout
ConclusionsIn the presence of elevated urate, human cartilage homogenates increase MSU crystal formation and promote the formation of smaller crystals which have greater inflammatory potential. These processes may contribute to the predilection of gout to osteoarthritic joints.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 11, 2019 Category: Rheumatology Authors: Ashika Chhana, Bregina Pool, Yicheng Wei, Ally Choi, Ryan Gao, Jacob Munro, Jillian Cornish, Nicola Dalbeth Tags: Full Length Source Type: research

A rare side effect of checkpoint inhibitor therapy:Nivolumab induced axial polyarthritis of the facet and costovertebral joints
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 11, 2019 Category: Rheumatology Authors: Jonas Feist, Antoine Murray, Alla Skapenko, Hendrik Schulze ‐Koops Tags: Clinical Image Source Type: research

Upadacitinib versus Placebo or Adalimumab in Patients with Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase 3, Double ‐Blind, Randomized Controlled Trial
AbstractObjectiveTo evaluate efficacy, including inhibition of radiographic progression, and safety of upadacitinib, a JAK1 ‐selective inhibitor, vs placebo and adalimumab in patients with rheumatoid arthritis and an inadequate response to methotrexate.Methods1629 patients with inadequate response to methotrexate were randomized (2:2:1) to once ‐daily upadacitinib 15mg, placebo, or adalimumab 40mg, on stable background methotrexate. Primary endpoints were ACR20 and DAS28CRP
Source: Arthritis and Rheumatology - July 9, 2019 Category: Rheumatology Authors: Roy Fleischmann, Aileen L Pangan, In ‐Ho Song, Eduardo Mysler, Louis Bessette, Charles Peterfy, Patrick Durez, Andrew J Ostor, Yihan Li, Yijie Zhou, Ahmed A Othman, Mark C Genovese Tags: Full Length Source Type: research

The IgG2 Isotype of Anti –Transcription Intermediary Factor 1γ Autoantibodies Is a Biomarker of Cancer and Mortality in Adult Dermatomyositis
ConclusionOur findings indicate that anti ‐TIF1γ IgG2 is a potential new biomarker of cancer that should be helpful in identifying the risk of mortality in anti‐TIF1γ–positive DM patients. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 8, 2019 Category: Rheumatology Authors: Audrey Aussy, Manuel Fr éret, Laure Gallay, Didier Bessis, Thierry Vincent, Denis Jullien, Laurent Drouot, Fabienne Jouen, Pascal Joly, Isabelle Marie, Alain Meyer, Jean Sibilia, Brigitte Bader‐Meunier, Eric Hachulla, Mohammed Hamidou, S Tags: Original Article Source Type: research

Failure of etanercept and methotrexate in combination to surpass etanercept alone in psoriatic arthritis (PsA) – what about the joint counts?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 4, 2019 Category: Rheumatology Authors: Arghya Chattopadhyay, Shefali K Sharma, G S R S N K Naidu, Varun Dhir Tags: Letter to the Editor Source Type: research

Exploratory study of MYD88 L265P, rare NLRP3 variants and clonal hematopoiesis prevalence in patients with Schnitzler's Syndrome
ConclusionA shared molecular mechanism accounting for the pathogenesis of inflammation in SchS remains elusive. CH is not associated with other somatic mutations found in SchS or aCAPS patients.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 3, 2019 Category: Rheumatology Authors: Shelly Pathak, Dorota M Rowczenio, Roger G Owen, Gina M Doody, Darren J Newton, Claire Taylor, Jan Taylor, Catherine Cargo, Philip N Hawkins, Karoline Krause, Helen J Lachmann, Sinisa Savic Tags: Brief Report Source Type: research

Comparative effectiveness of certolizumab pegol, abatacept and biosimilar infliximab in patients with rheumatoid arthritis treated in routine care. Observational data from the Danish DANBIO registry emulating a randomized trial
ConclusionThe surrogate randomization procedure enabled head ‐to‐head comparison of certolizumab pegol, abatacept and CT‐P13. Although some differences in the estimated effectiveness were observed across drugs, confidence intervals were wide and statistical significance was not reached.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 3, 2019 Category: Rheumatology Authors: Kathrine L. Gr øn, Bente Glintborg, Mette Nørgaard, Frank Mehnert, Mikkel Østergaard, Lene Dreyer, Niels S. Krogh, Jakob B. Bjorner, Merete L. Hetland Tags: Full Length Source Type: research

Takotsubo and Takayasu: A reason to rhyme?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 3, 2019 Category: Rheumatology Authors: Shir Lynn Lim, Ching Ching Ong, D.P.S. Dissanayake, Lynette Li San Teo, Sen Hee Tay Tags: Clinical Image Source Type: research

Activation of the Peroxisome Proliferator –Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis
This study was undertaken to investigate the contribution of PGC‐1β to circulating osteoclast precursors and its link to bone destruction in RA.MethodsPGC ‐1β expression in RA peripheral blood CD14+ monocytes was increased and showed correlation with joint destruction shown on radiographs. Cells from RA patients or healthy controls were transfected with a lentivirus vector for PGC‐1β gene silencing or overexpression and cultured with macrophage colony‐stimulating factor and RANKL. Bone resorption activity, bone‐degrading enzymes, and signaling molecules were measured in these mature osteoclasts.Res...
Source: Arthritis and Rheumatology - July 3, 2019 Category: Rheumatology Authors: Jian ‐Da Ma, Jun Jing, Jun‐Wei Wang, Ying‐Qian Mo, Qian‐Hua Li, Jian‐Zi Lin, Le‐Feng Chen, Lan Shao, Pierre Miossec, Lie Dai Tags: Original Article Source Type: research

Glucocorticoid Dosages and Acute ‐Phase Reactant Levels at Giant Cell Arteritis Flare in a Randomized Trial of Tocilizumab
ConclusionMost GCA flares occurred while patients were still receiving prednisone. Acute ‐phase reactant levels were not reliable indicators of flare in patients treated with TCZ plus prednisone or with prednisone alone. The addition of TCZ to prednisone facilitates earlier GCA control. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 3, 2019 Category: Rheumatology Authors: John H. Stone, Katie Tuckwell, Sophie Dimonaco, Micki Klearman, Martin Aringer, Daniel Blockmans, Elisabeth Brouwer, Maria C. Cid, Bhaskar Dasgupta, Juergen Rech, Carlo Salvarani, Hendrik Schulze ‐Koops, Georg Schett, Robert Spiera, Sebast Tags: Original Article Source Type: research

Disease Burden in Osteoarthritis Is Similar to That of Rheumatoid Arthritis at Initial Rheumatology Visit and Significantly Greater Six Months Later
ObjectiveTo analyze disease burden in osteoarthritis (OA) according to Multidimensional Health Assessment Questionnaire (MDHAQ)/Routine Assessment of Patient Index Data 3 (RAPID3) scores at the initial visit and the 6 ‐month follow‐up visit, compared with rheumatoid arthritis (RA) as a benchmark for high disease burden.MethodsAll patients with all diagnoses at the Rush University Medical Center Division of Rheumatology complete a paper MDHAQ at all visits, saved as a PDF in the electronic health record. MDHAQ 0 –10 scores for physical function, pain, and patient global assessment (compiled into RAPID3 0–30 ...
Source: Arthritis and Rheumatology - July 3, 2019 Category: Rheumatology Authors: Jacquelin R. Chua, Shakeel Jamal, Mariam Riad, Isabel Castrejon, Anne ‐Marie Malfait, Joel A. Block, Theodore Pincus Tags: Original Article Source Type: research

Pim ‐1 As a Therapeutic Target in Lupus Nephritis
This study was undertaken to test the hypothesis that inhibition of Pim‐1 would have therapeutic potential in patients with LN.MethodsPim ‐1 expression was analyzed in lupus‐prone (NZB × NZW)F1 mice (n = 6), human peripheral blood mononuclear cells (PBMCs) from SLE patients (n = 10), and glomeruli from patients with LN (n = 8). The therapeutic effect of the Pim‐1 inhibitor AZD1208 was assessed in the same murine lupus model (n = 10 mice per group). In vitro analysis was conducted to explore the mechanisms of action of Pim‐1 in mouse and human podocytes after Pim‐1 expression had been induced by anti&ndash...
Source: Arthritis and Rheumatology - July 2, 2019 Category: Rheumatology Authors: Rong Fu, Yong Xia, Meirong Li, Renxiang Mao, Chaohuan Guo, Mianjing Zhou, Hechang Tan, Meiling Liu, Shuang Wang, Niansheng Yang, Jijun Zhao Tags: Original Article Source Type: research

Unraveling the role of NSAIDs in the link between osteoarthritis and cardiovascular disease via causal mediation analysis – a guide to interpretation
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 1, 2019 Category: Rheumatology Authors: Kazuki Yoshida, Rishi Desai Tags: Editorial Source Type: research

MALT1 ‐deletion in T‐cells protects against the development of auto‐immune arthritis, but causes spontaneous osteoporosis
AbstractObjectivesMALT1 plays a crucial role in innate and adaptive immune signaling by modulating the threshold for activation of immune cells, including regulatory T ‐cells (Tregs). Therefore, MALT1 is regarded an interesting therapeutic target in several immune‐mediated diseases. Our goal was to examine the role of MALT1 in rheumatoid arthritis (RA).MethodsMALT1 ‐activation was assessed by measuring CYLD‐cleavage in lymphocytes of mice subjected to collagen‐induced arthritis (CIA). The impact of MALT1‐deficiency on arthritis was evaluated by inducing CIA and collagen‐antibody induced arthritis (CAIA) inMal...
Source: Arthritis and Rheumatology - July 1, 2019 Category: Rheumatology Authors: Elisabeth Gilis, Djoere Gaublomme, Jens Staal, Koen Venken, Maarten Dhaenens, Stijn Lambrecht, Julie Coudenys, Tine Decruy, Nadia Schryvers, Yasmine Driege, Emilie Dumas, Annelies Demeyer, Am élie De Muynck, Jolanda van Hengel, Luc Van Hoor Tags: Full Length Source Type: research

Winners of the 2018 American College of Rheumatology Annual Image Competition
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 1, 2019 Category: Rheumatology Authors: Rhonda Austell Tags: Special Source Type: research

Call for Caution in Using the Pain DETECT Questionnaire for Patient Stratification Without Additional Clinical Assessments: Comment on the Article by Soni et al
Arthritis&Rheumatology, Volume 71, Issue 7, Page 1201-1202, July 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Authors: Eivind Hasvik, Anne Julsrud Haugen, Lars Gr øvle Tags: Letters Source Type: research

Issue Information
Arthritis&Rheumatology, Volume 71, Issue 7, July 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Tags: Issue Information Source Type: research

Clinical Connections
Arthritis&Rheumatology, Volume 71, Issue 7, July 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Tags: Clinical Connections Source Type: research

In This Issue
Arthritis&Rheumatology, Volume 71, Issue 7, July 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Tags: In This Issue Source Type: research

ACR Announcements
Arthritis&Rheumatology, Volume 71, Issue 7, July 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Tags: ACR Announcements Source Type: research

Call for Caution in Using the Pain DETECT Questionnaire for Patient Stratifi cation Without Additional Clinical Assessments: Comment on the Article by Soni et al
Arthritis&Rheumatology, Volume 71, Issue 7, Page 1201-1202, July 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Authors: Eivind Hasvik, Anne Julsrud Haugen, Lars Gr øvle Tags: Letters Source Type: research

A Phase II Trial of Lutikizumab, an Anti –Interleukin‐1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis
ConclusionThe limited improvement in the WOMAC pain score and the lack of synovitis improvement with lutikizumab, together with published results from trials of other IL ‐1 inhibitors, suggest that IL‐1 inhibition is not an effective analgesic/antiinflammatory therapy in most patients with knee OA and associated synovitis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Authors: Roy M. Fleischmann, Henning Bliddal, Francisco J. Blanco, Thomas J. Schnitzer, Charles Peterfy, Su Chen, Li Wang, Sheng Feng, Philip G. Conaghan, Francis Berenbaum, Jean ‐Pierre Pelletier, Johanne Martel‐Pelletier, Ole Vaeterlein, Gurjit Tags: Original Article Source Type: research

Bone Lesions in Erdheim ‐Chester Disease
Arthritis&Rheumatology, Volume 71, Issue 7, Page 1206-1206, July 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 26, 2019 Category: Rheumatology Authors: Jean W. Liew, Gordon Starkebaum Tags: Clinical Image Source Type: research

Comparative study of infliximab versus adalimumab in refractory uveitis due to Beh çet's disease, National multicenter study of 177 cases
ConclusionAlthough IFX and ADA yields efficacy refractory BD uveitis, ADA appears to be associated with better outcome than IFX after one ‐year follow‐up.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 25, 2019 Category: Rheumatology Authors: Bel én Atienza‐Mateo, José Luis Martín‐Varillas, Vanesa Calvo‐Río, Rosalía Demetrio‐Pablo, Emma Beltrán, Juan Sánchez‐Bursón, Marina Mesquida, Alfredo Adan, María Victoria Hernández, Marisa Hernández‐Garfella, Elia Valls Tags: Full Length Source Type: research

The maternal and paternal effects on clinical and surgical definitions of osteoarthritis
ConclusionOA in the mother increased the risk of surgical and clinical definitions of hip, knee and hand OA in the offspring and particularly in daughters. Our findings imply that heredity of OA may be linked to maternal genes and/or maternal ‐specific factors such as the fetal environment.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 25, 2019 Category: Rheumatology Authors: Eirik Weldingh, Marianne Bakke Johnsen, K åre Birger Hagen, Nina Østerås, May Arna Risberg, Bård Natvig, Barbara Slatkowsky‐Christensen, Anne Marie Fenstad, Ove Furnes, Lars Nordsletten, Karin Magnusson Tags: Brief Report Source Type: research

Pneumoproteins KL ‐6 and CCL‐18 Predict Progression of Interstitial Lung Disease in Systemic Sclerosis
AbstractObjectiveTo investigate the relationship between Krebs von den Lungen ‐6 [KL‐6] and CC chemokine ligand 2 [CCL‐18]) with severity and progression of systemic sclerosis‐related interstitial lung disease (SSc‐ILD).MethodsPatients enrolled in Scleroderma Lung Study (SLS) II (cyclophosphamide [CYC] versus mycophenolate mofetil [MMF]) were included. Baseline and 12 ‐month plasma samples were analyzed by ELISA to assess CCL‐18 and KL‐6 levels. The forced vital capacity (FVC) and the diffusing capacity for carbon monoxide (DLCO) were measured every 3 months. Joint models were created to investigate the rel...
Source: Arthritis and Rheumatology - June 24, 2019 Category: Rheumatology Authors: Elizabeth R. Volkmann, Donald P. Tashkin, Masataka Kuwana, Ning Li, Michael D. Roth, Julio Charles, Faye N. Hant, Galina S. Bogatkevich, Tanjina Akter, Grace Kim, Jonathan Goldin, Dinesh Khanna, Philip J. Clements, Daniel E. Furst, Robert M. Tags: Full Length Source Type: research

Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2019 Category: Rheumatology Authors: Claas H. Hinze, Dirk Foell Tags: Reply to Letter to the Editor Source Type: research

Fibrocytes in Chronic Periaortitis
ConclusionsFibrocytes are enriched in the peripheral blood of CP patients and infiltrate target lesions; their accumulation in the pathologic tissue might be driven by CXCL12, and Th2 ‐skewed immune responses are likely to facilitate their differentiation.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2019 Category: Rheumatology Authors: Maria Nicastro, Rosanna Vescovini, Federica Maritati, Alessandra Palmisano, Maria L. Urban, Monia Incerti, Paride Fenaroli, Francesco Peyronel, Giuseppe D. Benigno, Domenica Mangieri, Riccardo Volpi, Gabriella Becchi, Paola Romagnani, Domenic Tags: Full Length Source Type: research

Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus ‐like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis
AbstractObjectiveGlutaminase 1 (Gls1) is the first enzyme in glutaminolysis. The selective Gls1 inhibitor Bis ‐2‐(5‐phenylacetamido‐1,3,4‐thiadiazol‐2‐yl)ethyl sulfide (BPTES) suppresses Th17 development and ameliorates experimental autoimmune encephalomyelitis (EAE). However, whether inhibition of glutaminolysis is beneficial for the treatment of systemic lupus erythematosus (SLE) and the inv olved mechanisms are still unknown.MethodsMRL/lpr mice were treated by BPTES or vehicle control and disease activity was examined. Then na ïve CD4+ T cells from patients with SLE were cultured under Th17 conditions...
Source: Arthritis and Rheumatology - June 24, 2019 Category: Rheumatology Authors: Michihito Kono, Nobuya Yoshida, Kayaho Maeda, Abel Su árez‐Fueyo, Vasileios C. Kyttaris, George C. Tsokos Tags: Full Length Source Type: research

Questions regarding the relationship between serum levels of S100A8/A9 and S100A12 and the maintenance of clinically inactive disease in JIA: Comment on the article by Claas H. Hinze et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 24, 2019 Category: Rheumatology Authors: Emmanuelle Rochette, Bruno Pereira, Etienne Merlin Tags: Letter to the Editor Source Type: research

Clinical Images: Dual ‐energy computed tomography for the noninvasive diagnosis of coexisting gout and calcium pyrophosphate deposition disease
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 20, 2019 Category: Rheumatology Authors: Rami Hajri, Steven D. Hajdu, Thomas H ügle, Pascal Zufferey, Laurent Guiral, Fabio Becce Tags: Clinical Images Source Type: research

Measuring circulating complement activation products in myeloperoxidase and proteinase 3 antineutrophil cytoplasmic antibody vasculitis
AbstractObjectiveThere is accumulating evidence that complement activation is important in ANCA vasculitis pathogenesis. Our objective was to investigate complement activation in MPO ‐ANCA and PR3‐ANCA vasculitis after determining optimal methods for measuring activated complement factors in circulation.MethodsSubjects included 98 patients with ANCA vasculitis (45 MPO ‐ANCA, 53 PR3‐ANCA) and 35 healthy controls. Plasma was obtained from blood collected in EDTA tubes including no or 100 μg/mL futhan. Bb, C3a, C5a, sC5b‐9, properdin, and C4d levels were measured by ELISA. Group comparisons were made using Wilcox...
Source: Arthritis and Rheumatology - June 19, 2019 Category: Rheumatology Authors: Eveline Y. Wu, Elizabeth A. McInnis, Sonia Boyer ‐Suavet, Carmen E. Mendoza, Lydia T. Aybar, Kristin B. Kennedy, Caroline J. Poulton, Candace D. Henderson, Yichun Hu, Susan L. Hogan, Peiqi Hu, Hong Xiao, Patrick H. Nachman, J. Charles Jenne Tags: Full Length Source Type: research

Response to letters: Denosumab Versus Risedronate in Glucocorticoid ‐Induced Osteoporosis: Final Results of a Twenty‐Four–Month Randomized, Double‐Blind, Double‐Dummy Trial
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 19, 2019 Category: Rheumatology Authors: Kenneth G. Saag, Piet Geusens, Willem F. Lems Tags: Reply to Letter to the Editor Source Type: research

Bisphosphonates remain a first choice treatment for glucocorticoid ‐induced osteoporosis: Comment on the Article by Saag et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 19, 2019 Category: Rheumatology Authors: Elena Gonzalez Rodriguez, B érengère Aubry‐Rozier, Delphine Stoll, Olivier Lamy Tags: Letter to the Editor Source Type: research

Denosumab – where does it stand in the GIOP armamentarium?
AbstractWe read with interest, the article on ‘Denosumab vs. risedronate in glucocorticoid‐induced osteoporosis: final results of a 24‐month randomized, double‐blind, double‐dummy trial ‘ by Saag KG et al. [1] Osteoporosis in a setting of glucocorticoid‐induced osteoporosis (GIOP) is challenging because of issues with drug adhere nce (due to the pill burden) and the presence of multiple comorbidities. Denosumab is a welcome addition in the armamentarium of this disease due to its once‐in‐six months dosing, which is associated with better adherence than bisphosphonates[2] and its renal safety ...
Source: Arthritis and Rheumatology - June 19, 2019 Category: Rheumatology Authors: Arghya Chattopadhyay, Shefali K Sharma, Aman Sharma, Sanjay jain, Varun Dhir Tags: Letter to the Editor Source Type: research

The Association of Pulmonary Haemorrhage, Positive PR3 ‐ANCA and Urinary Red Blood Cell Casts with Venous Thromboembolism in ANCA‐Associated Vasculitis
ConclusionPatients with ANCA ‐associated vasculitis with pulmonary haemorrhage, positive PR3‐ANCA, heart involvement and presence of red blood cell casts are at an increased risk to develop VTEs. Further studies are needed to confirm and expand these findings and to explore the mechanisms of hypercoagulability in these pati ents with the aim of informing potential targets for therapeutic intervention.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 19, 2019 Category: Rheumatology Authors: Andreas Kronbichler, Johannes Leierer, Jae Il Shin, Peter A. Merkel, Robert Spiera, Philip Seo, Carol A. Langford, Gary S. Hoffman, Cees G.M. Kallenberg, E. William St.Clair, Paul Brunetta, Fernando C. Fervenza, Duvuru Geetha, Karina A. Keogh Tags: Brief Report Source Type: research

Novel Inter ‐omic Analysis Reveals Relationships Between Diverse Gut Microbiota and Host Immune Dysregulation in HLA‐B27‐Induced Experimental Spondyloarthritis
ConclusionsInter ‐omic and network anaylsis of gut microbes and the host immune response in experimental SpA provides an unprecedented view of organisms strongly linked to dysregulated IL‐23, IL‐17, IL‐1, IFN‐γ, and TNF pathways. Functional similarities between these organisms may explain why different ge netic backgrounds exhibit common patterns of immune dysregulation, possibly through perturbation of similar metabolic pathways. These results highlight the power of linking analyses of gut microbiota with the host immune response to gain insights into role of dysbiotic microbes in SpA beyond taxonom ic pro...
Source: Arthritis and Rheumatology - June 19, 2019 Category: Rheumatology Authors: Tejpal Gill, Stephen R. Brooks, James T. Rosenbaum, Mark Asquith, Robert A. Colbert Tags: Brief Report Source Type: research

Hypertrophic osteoarthropathy presenting with joint pain in cystic fibrosis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - June 19, 2019 Category: Rheumatology Authors: Elizabeth Clarke, Rowland Bright ‐Thomas Tags: Clinical Image Source Type: research