Phosphatidic Acid Promoting the Generation of Interleukin ‐17A Producing Double‐Negative T Cells by Enhancing mTORC1 Signaling in Lupus

ConclusionThe accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus.

Source: Arthritis and Rheumatology - April 17, 2024 Category: Rheumatology Authors: Wenjing Li, Xiaojun Tang, Yuanyuan Zheng, Xuefeng Xu, Nan Zhao, Betty P. Tsao, Xuebing Feng, Lingyun Sun Tags: Full Length Source Type: research