Single-cell sequencing reveals distinct immune cell features in cutaneous lesions of pemphigus vulgaris and bullous pemphigoid
Clin Immunol. 2024 Apr 15:110219. doi: 10.1016/j.clim.2024.110219. Online ahead of print.ABSTRACTBullous pemphigoid (BP) and pemphigus vulgaris (PV) are two common subtypes of autoimmune bullous disease (AIBD). The key role of circulating autoreactive immune cells contributing to skin damage of AIBD has been widely recognized. Nevertheless, the immune characteristics in cutaneous lesions remain unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell VDJ sequencing (scRNA-seq) to generate transcriptional profiles for cells and T/B cell clonetype in skin lesions of BP and PV. We found that the prop...
Source: Clinical Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Zhi Hu Meiling Zheng Ziyu Guo Wenhui Zhou Wenyu Zhou Nan Yao Guiying Zhang Qianjin Lu Ming Zhao Source Type: research
ICOS agonist vopratelimab modulates follicular helper T cells and improves B cell function in common variable immunodeficiency
Clin Immunol. 2024 Apr 13:110217. doi: 10.1016/j.clim.2024.110217. Online ahead of print.ABSTRACTCommon variable immunodeficiency (CVID) is an immune defect characterized by hypogammaglobulinemia and impaired development of B cells into plasma cells. As follicular helper T cells (TFH) play a central role in humoral immunity, we examined TFH cells in CVID, and investigated whether an inducible T cell co-stimulator (ICOS) agonist, vopratelimab, could modulate TFH, B cell interactions and enhance immunoglobulin production. CVID subjects had decreased TFH17 and increased TFH1 subsets; this was associated with increased transit...
Source: Clinical Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Ali Sepahi Hsi-En Ho Prapti Vyas Benjamin Umiker Katalin Kis-Toth Dmitri Wiederschain Lin Radigan Charlotte Cunningham-Rundles Source Type: research
ICOS agonist vopratelimab modulates follicular helper T cells and improves B cell function in common variable immunodeficiency
Clin Immunol. 2024 Apr 13:110217. doi: 10.1016/j.clim.2024.110217. Online ahead of print.ABSTRACTCommon variable immunodeficiency (CVID) is an immune defect characterized by hypogammaglobulinemia and impaired development of B cells into plasma cells. As follicular helper T cells (TFH) play a central role in humoral immunity, we examined TFH cells in CVID, and investigated whether an inducible T cell co-stimulator (ICOS) agonist, vopratelimab, could modulate TFH, B cell interactions and enhance immunoglobulin production. CVID subjects had decreased TFH17 and increased TFH1 subsets; this was associated with increased transit...
Source: Clinical Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Ali Sepahi Hsi-En Ho Prapti Vyas Benjamin Umiker Katalin Kis-Toth Dmitri Wiederschain Lin Radigan Charlotte Cunningham-Rundles Source Type: research
Porto-sinusoidal vascular disorder and nephrotic-range proteinuria due to venous vasculitis in Beh çet's disease
We report a case of an Iranian male that presented with porto-sinusoidal vascular disorder due to venous vasculitis as initial manifestation of BD. Despite immunosuppression and anticoagulation, he subsequently developed severe nephrotic-range proteinuria that mimicked a primary renal disease but was completely and immediately ameliorated by stenting of the vena cava. This demonstrates that the proteinuria was caused by increased intraglomerular pressure due to venous outflow obstruction as a consequence of venous vasculitis. To our knowledge, this is the first report of massive proteinuria caused by venous obstruction of ...
Source: Clinical Immunology - April 12, 2024 Category: Allergy & Immunology Authors: M E Annink T B van der Houwen J J T H Roelofs R B Takkenberg J A M van Laar N C van der Weerd A E Hak A J Kwakernaak Source Type: research
Porto-sinusoidal vascular disorder and nephrotic-range proteinuria due to venous vasculitis in Beh çet's disease
We report a case of an Iranian male that presented with porto-sinusoidal vascular disorder due to venous vasculitis as initial manifestation of BD. Despite immunosuppression and anticoagulation, he subsequently developed severe nephrotic-range proteinuria that mimicked a primary renal disease but was completely and immediately ameliorated by stenting of the vena cava. This demonstrates that the proteinuria was caused by increased intraglomerular pressure due to venous outflow obstruction as a consequence of venous vasculitis. To our knowledge, this is the first report of massive proteinuria caused by venous obstruction of ...
Source: Clinical Immunology - April 12, 2024 Category: Allergy & Immunology Authors: M E Annink T B van der Houwen J J T H Roelofs R B Takkenberg J A M van Laar N C van der Weerd A E Hak A J Kwakernaak Source Type: research
Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
CONCLUSIONS: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.PMID:38604255 | DOI:10.1016/j.clim.2024.110214 (Source: Clinical Immunology)
Source: Clinical Immunology - April 11, 2024 Category: Allergy & Immunology Authors: E M D Smith A Aggarwal J Ainsworth E Al-Abadi T Avcin L Bortey J Burnham C Ciurtin C M Hedrich S Kamphuis L Lambert D M Levy L Lewandowski N Maxwell E Morand S Özen C E Pain A Ravelli C Saad Magalhaes C Pilkington D Schonenberg-Meinema C Scott K Tullus M Source Type: research
Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
CONCLUSIONS: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.PMID:38604255 | DOI:10.1016/j.clim.2024.110214 (Source: Clinical Immunology)
Source: Clinical Immunology - April 11, 2024 Category: Allergy & Immunology Authors: E M D Smith A Aggarwal J Ainsworth E Al-Abadi T Avcin L Bortey J Burnham C Ciurtin C M Hedrich S Kamphuis L Lambert D M Levy L Lewandowski N Maxwell E Morand S Özen C E Pain A Ravelli C Saad Magalhaes C Pilkington D Schonenberg-Meinema C Scott K Tullus M Source Type: research
P75 < sup > NTR+ < /sup > CD64 < sup > + < /sup > neutrophils promote sepsis-induced acute lung injury
In this study, we found a significant elevation of CD64+ neutrophils, which highly expressed p75 neurotrophin receptor (p75NTR) in peripheral blood of mice and patients with sepsis-induced ALI. p75NTR+CD64+ neutrophils were also abundantly expressed in the lung of ALI mice induced by lipopolysaccharide. Conditional knock-out of the myeloid lineage's p75NTR gene improved the survival rates, attenuated lung tissue inflammation, reduced neutrophil infiltration and enhanced the phagocytic functions of CD64+ neutrophils. In vitro, p75NTR+CD64+ neutrophils exhibited an upregulation and compromised phagocytic activity in blood sa...
Source: Clinical Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Di Fu Shan Gao Jia-Nan Li Yan-Hui Cui Yan-Wei Luo Yan-Jun Zhong Qiao Li Cong Luo Ru-Ping Dai Ru-Yi Luo Zhao-Lan Hu Source Type: research
P75 < sup > NTR+ < /sup > CD64 < sup > + < /sup > neutrophils promote sepsis-induced acute lung injury
In this study, we found a significant elevation of CD64+ neutrophils, which highly expressed p75 neurotrophin receptor (p75NTR) in peripheral blood of mice and patients with sepsis-induced ALI. p75NTR+CD64+ neutrophils were also abundantly expressed in the lung of ALI mice induced by lipopolysaccharide. Conditional knock-out of the myeloid lineage's p75NTR gene improved the survival rates, attenuated lung tissue inflammation, reduced neutrophil infiltration and enhanced the phagocytic functions of CD64+ neutrophils. In vitro, p75NTR+CD64+ neutrophils exhibited an upregulation and compromised phagocytic activity in blood sa...
Source: Clinical Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Di Fu Shan Gao Jia-Nan Li Yan-Hui Cui Yan-Wei Luo Yan-Jun Zhong Qiao Li Cong Luo Ru-Ping Dai Ru-Yi Luo Zhao-Lan Hu Source Type: research
New and emerging therapies for systemic lupus erythematosus
Clin Immunol. 2024 Apr 4:110200. doi: 10.1016/j.clim.2024.110200. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targetin...
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Eleni Papachristodoulou Vasileios C Kyttaris Source Type: research
Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia
CONCLUSION: Our findings present a provocative possibility of resetting R-loops as a therapeutic intervention to correct both immune deficiency and malignancy in T-cell acute lymphoblastic leukemia patients and a novel role of WASp in the epigenetic regulation of T helper cell differentiation in T-ALL patients, anticipating WASp's requirement for the suppression of T-ALL progression.PMID:38582251 | DOI:10.1016/j.clim.2024.110204 (Source: Clinical Immunology)
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: R Pradeep Sudeshna Rakshit Geetha Shanmugam Melvin George Koustav Sarkar Source Type: research
New and emerging therapies for systemic lupus erythematosus
Clin Immunol. 2024 Apr 4:110200. doi: 10.1016/j.clim.2024.110200. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targetin...
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Eleni Papachristodoulou Vasileios C Kyttaris Source Type: research
Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia
CONCLUSION: Our findings present a provocative possibility of resetting R-loops as a therapeutic intervention to correct both immune deficiency and malignancy in T-cell acute lymphoblastic leukemia patients and a novel role of WASp in the epigenetic regulation of T helper cell differentiation in T-ALL patients, anticipating WASp's requirement for the suppression of T-ALL progression.PMID:38582251 | DOI:10.1016/j.clim.2024.110204 (Source: Clinical Immunology)
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: R Pradeep Sudeshna Rakshit Geetha Shanmugam Melvin George Koustav Sarkar Source Type: research
New and emerging therapies for systemic lupus erythematosus
Clin Immunol. 2024 Apr 4:110200. doi: 10.1016/j.clim.2024.110200. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targetin...
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Eleni Papachristodoulou Vasileios C Kyttaris Source Type: research
Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia
CONCLUSION: Our findings present a provocative possibility of resetting R-loops as a therapeutic intervention to correct both immune deficiency and malignancy in T-cell acute lymphoblastic leukemia patients and a novel role of WASp in the epigenetic regulation of T helper cell differentiation in T-ALL patients, anticipating WASp's requirement for the suppression of T-ALL progression.PMID:38582251 | DOI:10.1016/j.clim.2024.110204 (Source: Clinical Immunology)
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: R Pradeep Sudeshna Rakshit Geetha Shanmugam Melvin George Koustav Sarkar Source Type: research
