Interleukin 4 promotes anti-inflammatory macrophages that clear cartilage debris and inhibits osteoclast development to protect against osteoarthritis
CONCLUSION: Our findings demonstrate that IL-4 protects against osteoarthritis in a myeloid and STAT6-dependent manner. Further, IL-4 can promote an immunomodulatory microenvironment in which joint-resident macrophages polarize towards an M2 phenotype and efficiently clear pro-inflammatory debris, and osteoclasts maintain a homeostatic level of activity in subchondral bone. These findings support a role for IL-4 modulation of myeloid cell types in maintenance of joint health and identify a pathway that could provide therapeutic benefit for osteoarthritis.PMID:34126239 | DOI:10.1016/j.clim.2021.108784 (Source: Clinical Immunology)
Source: Clinical Immunology - June 14, 2021 Category: Allergy & Immunology Authors: Ericka P von Kaeppler Qian Wang Harini Raghu Michelle S Bloom Heidi Wong William H Robinson Source Type: research

Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS
Clin Immunol. 2021 Jun 9;229:108780. doi: 10.1016/j.clim.2021.108780. Online ahead of print.ABSTRACTOverlapping clinical features promoted the discussion of whether Kawasaki disease (KD) and PIMS-TS share pathophysiological features and disease outcomes. Medical records from English patients with KD (2015-02/20, N = 27) and PIMS-TS (02/2020-21, N = 34) were accessed to extract information. Children with PIMS-TS were older and more frequently of minority ethnicity background. They patients more commonly exhibited cytopenias and hyperferritinemia, which associated with diffuse cardiac involvement and functional impairment. I...
Source: Clinical Immunology - June 12, 2021 Category: Allergy & Immunology Authors: Susanna Felsenstein Phuoc Duong Steven Lane Caroline Jones Clare E Pain Christian M Hedrich Source Type: research

Immunological abnormalities in patients with early-onset ataxia with ocular motor apraxia and hypoalbuminemia
In this study, we report that EAOH patients have immunological abnormalities, including lymphopenia; decreased levels of CD4+ T-cells, CD8+ T-cells, and B-cells; hypogammaglobulinemia; low T-cell recombination excision circles and kappa-deleting element recombination circles; and oligoclonality of T-cell receptor β-chain variable repertoire. These immunological abnormalities vary among the EAOH patients. Additionally, mild radiosensitivity in the lymphocytes obtained from the patients with EAOH was demonstrated. These findings suggested that the immunological abnormalities and mild radiosensitivity evident in patients...
Source: Clinical Immunology - June 12, 2021 Category: Allergy & Immunology Authors: Tamaki Kato Yoshiteru Tamura Hiroshi Matsumoto Osamu Kobayashi Hideaki Ishiguro Masaya Ogawa Koyo Tsujikawa Yasuhiro Hasegawa Mitsuhiro Sakamoto Masaaki Konagaya Hideki Houzen Masatoshi Takagi Kohsuke Imai Tomohiro Morio Akio Yokoseki Osamu Onodera Shigea Source Type: research

Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults
The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Antibody levels against endemic hCoVs start to rise at a very early age, reaching to overall 100% seroprevalence. No difference in the antibody levels was detected for OC43 but the magnitude of 229E-specific antibodies was significantly higher in the sera of children. OC43 and 229E hCoV antibody levels of children correlated significantly with each other and with the level of cross-reactive SARS-CoV-2 antibodies, whereas these correlations compl...
Source: Clinical Immunology - June 12, 2021 Category: Allergy & Immunology Authors: Kirsi Tamminen Marjo Salminen Vesna Blazevic Source Type: research

Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS
Clin Immunol. 2021 Jun 9:108780. doi: 10.1016/j.clim.2021.108780. Online ahead of print.ABSTRACTOverlapping clinical features promoted the discussion of whether Kawasaki disease (KD) and PIMS-TS share pathophysiological features and disease outcomes. Medical records from English patients with KD (2015-02/20, N = 27) and PIMS-TS (02/2020-21, N = 34) were accessed to extract information. Children with PIMS-TS were older and more frequently of minority ethnicity background. They patients more commonly exhibited cytopenias and hyperferritinemia, which associated with diffuse cardiac involvement and functional impairment. In so...
Source: Clinical Immunology - June 12, 2021 Category: Allergy & Immunology Authors: Susanna Felsenstein Phuoc Duong Steven Lane Caroline Jones Clare E Pain Christian M Hedrich Source Type: research

Immunological abnormalities in patients with early-onset ataxia with ocular motor apraxia and hypoalbuminemia
In this study, we report that EAOH patients have immunological abnormalities, including lymphopenia; decreased levels of CD4+ T-cells, CD8+ T-cells, and B-cells; hypogammaglobulinemia; low T-cell recombination excision circles and kappa-deleting element recombination circles; and oligoclonality of T-cell receptor β-chain variable repertoire. These immunological abnormalities vary among the EAOH patients. Additionally, mild radiosensitivity in the lymphocytes obtained from the patients with EAOH was demonstrated. These findings suggested that the immunological abnormalities and mild radiosensitivity evident in patients...
Source: Clinical Immunology - June 12, 2021 Category: Allergy & Immunology Authors: Tamaki Kato Yoshiteru Tamura Hiroshi Matsumoto Osamu Kobayashi Hideaki Ishiguro Masaya Ogawa Koyo Tsujikawa Yasuhiro Hasegawa Mitsuhiro Sakamoto Masaaki Konagaya Hideki Houzen Masatoshi Takagi Kohsuke Imai Tomohiro Morio Akio Yokoseki Osamu Onodera Shigea Source Type: research

Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults
The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Antibody levels against endemic hCoVs start to rise at a very early age, reaching to overall 100% seroprevalence. No difference in the antibody levels was detected for OC43 but the magnitude of 229E-specific antibodies was significantly higher in the sera of children. OC43 and 229E hCoV antibody levels of children correlated significantly with each other and with the level of cross-reactive SARS-CoV-2 antibodies, whereas these correlations compl...
Source: Clinical Immunology - June 12, 2021 Category: Allergy & Immunology Authors: Kirsi Tamminen Marjo Salminen Vesna Blazevic Source Type: research

Interaction between Ras and Bcl2L12 in B cells suppresses IL-10 expression
In conclusion, Bcl2L12 interacts with Ras activation to compromise immune tolerance in the tonsils by inhibiting the IL-10 expression in tBCs. Inhibition of Bcl2L12 can restore the IL-10 expression in tBCs.PMID:34116211 | DOI:10.1016/j.clim.2021.108775 (Source: Clinical Immunology)
Source: Clinical Immunology - June 11, 2021 Category: Allergy & Immunology Authors: Jianxiang Li Gui Yang Xiang-Qian Luo Li-Hua Mo Shu-Yao Qiu Li-Tao Yang Da-Bo Liu Yun-Fang An Ping-Chang Yang Source Type: research

Genetic variant within CDK6 regulates immune response to palbociclib treatment
Clin Immunol. 2021 Jun 8:108777. doi: 10.1016/j.clim.2021.108777. Online ahead of print.ABSTRACTEveryone carries a set of genetic variants that contribute to regulation of the levels of blood cells, with unknown clinical impact. One of them, rs445 within the cell-cycle checkpoint gene CDK6, reduces the levels of myeloid cell types including granulocytes. We treated CD3+ T cells and whole blood with palbociclib in 41 individuals, who were stratified by genotype for analyses. In T cells we assessed cell cycle and apoptosis, whereas in whole blood, apoptosis in activated (CD11b+), unactivated (CD11b-) granulocytes, cytotoxic ...
Source: Clinical Immunology - June 11, 2021 Category: Allergy & Immunology Authors: Valentina Serra Valeria Orr ù Maristella Steri Edoardo Fiorillo Francesco Cucca Magdalena Zoledziewska Source Type: research

Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency
Clin Immunol. 2021 Jun 8:108779. doi: 10.1016/j.clim.2021.108779. Online ahead of print.ABSTRACTCTLA4-haploinsufficiency is a complex disease of immune dysregulation presenting with a broad spectrum of clinical manifestations. CTLA4-Fc fusion proteins such as abatacept have been described to alleviate immune dysregulation in several adult cases of CTLA4-haploinsufficiency. However, until now only few cases of pediatric CTLA4-haploinsufficiency treated with abatacept have been described. Here we present two pediatric cases of severe CTLA4-haploinsufficiency refractory to conventional immunosuppressive therapies that respond...
Source: Clinical Immunology - June 11, 2021 Category: Allergy & Immunology Authors: Anna-Lisa Lanz Martin Riester Philipp Peters Tobias Schwerd Eberhard Lurz Mohammad Samer Hajji Meino Rohlfs Julia Ley-Zaporozhan Christoph Walz Daniel Kotlarz Christoph Klein Michael H Albert Fabian Hauck Source Type: research

Combining multi-antigenic immunodot with indirect immunofluorescence on HEp-2 cells improves the diagnosis of systemic sclerosis
Clin Immunol. 2021 Jun 7:108774. doi: 10.1016/j.clim.2021.108774. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is associated, in nearly all patients, with autoantibodies (Ab). Accordingly, and in order to identify major (anti-CEN A/B and anti-Topo I) but also minor Abs, the usefulness of combining indirect immunofluorescence (IIF) on HEp-2 cells with an 11 multi-antigenic SSc immunodot was explored. 1689 samples tested at the request of clinicians, were evaluated retrospectively. The positivity rate was 28.8% and the diagnosis of SSc was supported for 232 samples. Two groups of Abs were considered: group 1, Abs (...
Source: Clinical Immunology - June 10, 2021 Category: Allergy & Immunology Authors: Bost Chlo é Fortenfant Fran çoise Antoine Blancher Pugnet Gr égory Renaudineau Yves Source Type: research

Combining multi-antigenic immunodot with indirect immunofluorescence on HEp-2 cells improves the diagnosis of systemic sclerosis
Clin Immunol. 2021 Jun 7:108774. doi: 10.1016/j.clim.2021.108774. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is associated, in nearly all patients, with autoantibodies (Ab). Accordingly, and in order to identify major (anti-CEN A/B and anti-Topo I) but also minor Abs, the usefulness of combining indirect immunofluorescence (IIF) on HEp-2 cells with an 11 multi-antigenic SSc immunodot was explored. 1689 samples tested at the request of clinicians, were evaluated retrospectively. The positivity rate was 28.8% and the diagnosis of SSc was supported for 232 samples. Two groups of Abs were considered: group 1, Abs (...
Source: Clinical Immunology - June 10, 2021 Category: Allergy & Immunology Authors: Bost Chlo é Fortenfant Fran çoise Antoine Blancher Pugnet Gr égory Renaudineau Yves Source Type: research

Dynamics of HIV reservoir decay and na ïve CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatment
CONCLUSIONS: INR maintained significantly higher viral reservoir and lower naïve CD4 T-cells compared with CR during 5-year ART, however, the rates of reservoir decay and naïve CD4 T-cell percentage growth within INR were not lower than that in CR over time.PMID:34102315 | DOI:10.1016/j.clim.2021.108773 (Source: Clinical Immunology)
Source: Clinical Immunology - June 8, 2021 Category: Allergy & Immunology Authors: Lu-Xue Zhang Jin-Wen Song Chao Zhang Xing Fan Hui-Huang Huang Ruo-Nan Xu Jia-Ye Liu Ji-Yuan Zhang Li-Feng Wang Chun-Bao Zhou Lei Jin Ming Shi Fu-Sheng Wang Yan-Mei Jiao Source Type: research

Dynamics of HIV reservoir decay and na ïve CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatment
CONCLUSIONS: INR maintained significantly higher viral reservoir and lower naïve CD4 T-cells compared with CR during 5-year ART, however, the rates of reservoir decay and naïve CD4 T-cell percentage growth within INR were not lower than that in CR over time.PMID:34102315 | DOI:10.1016/j.clim.2021.108773 (Source: Clinical Immunology)
Source: Clinical Immunology - June 8, 2021 Category: Allergy & Immunology Authors: Lu-Xue Zhang Jin-Wen Song Chao Zhang Xing Fan Hui-Huang Huang Ruo-Nan Xu Jia-Ye Liu Ji-Yuan Zhang Li-Feng Wang Chun-Bao Zhou Lei Jin Ming Shi Fu-Sheng Wang Yan-Mei Jiao Source Type: research

Dynamics of HIV reservoir decay and na ïve CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatment
CONCLUSIONS: INR maintained significantly higher viral reservoir and lower naïve CD4 T-cells compared with CR during 5-year ART, however, the rates of reservoir decay and naïve CD4 T-cell percentage growth within INR were not lower than that in CR over time.PMID:34102315 | DOI:10.1016/j.clim.2021.108773 (Source: Clinical Immunology)
Source: Clinical Immunology - June 8, 2021 Category: Allergy & Immunology Authors: Lu-Xue Zhang Jin-Wen Song Chao Zhang Xing Fan Hui-Huang Huang Ruo-Nan Xu Jia-Ye Liu Ji-Yuan Zhang Li-Feng Wang Chun-Bao Zhou Lei Jin Ming Shi Fu-Sheng Wang Yan-Mei Jiao Source Type: research

Farnesol induces protection against murine CNS inflammatory demyelination and modifies gut microbiome
Clin Immunol. 2021 Jun 3:108766. doi: 10.1016/j.clim.2021.108766. Online ahead of print.ABSTRACTFarnesol is a 15‑carbon organic isoprenol synthesized by plants and mammals with anti-oxidant, anti-inflammatory, and neuroprotective activities. We sought to determine whether farnesol treatment would result in protection against murine experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis (MS). We compared disease progression and severity in C57BL/6 mice treated orally with 100 mg/kg/day farnesol solubilized in corn oil to corn-oil treated and untreated EAE mice. Farnesol significant...
Source: Clinical Immunology - June 6, 2021 Category: Allergy & Immunology Authors: Lacey B Sell Christina C Ramelow Hannah M Kohl Kristina Hoffman Jasleen K Bains William J Doyle Kevin D Strawn Theresa Hevrin Trevor O Kirby K Michael Gibson Jean-Baptiste Roullet Javier Ochoa-Rep áraz Source Type: research

Farnesol induces protection against murine CNS inflammatory demyelination and modifies gut microbiome
Clin Immunol. 2021 Jun 3:108766. doi: 10.1016/j.clim.2021.108766. Online ahead of print.ABSTRACTFarnesol is a 15‑carbon organic isoprenol synthesized by plants and mammals with anti-oxidant, anti-inflammatory, and neuroprotective activities. We sought to determine whether farnesol treatment would result in protection against murine experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis (MS). We compared disease progression and severity in C57BL/6 mice treated orally with 100 mg/kg/day farnesol solubilized in corn oil to corn-oil treated and untreated EAE mice. Farnesol significant...
Source: Clinical Immunology - June 6, 2021 Category: Allergy & Immunology Authors: Lacey B Sell Christina C Ramelow Hannah M Kohl Kristina Hoffman Jasleen K Bains William J Doyle Kevin D Strawn Theresa Hevrin Trevor O Kirby K Michael Gibson Jean-Baptiste Roullet Javier Ochoa-Rep áraz Source Type: research

Effective DNA damage response after acute but not chronic immune challenge: SARS-CoV-2 vaccine versus Systemic Lupus Erythematosus
Clin Immunol. 2021 Jun 2:108765. doi: 10.1016/j.clim.2021.108765. Online ahead of print.ABSTRACTWhether and how an acute immune challenge may affect DNA Damage Response (DDR) is unknown. By studying vaccinations against Influenza and SARS-CoV-2 (mRNA-based) we found acute increases of type-I interferon-inducible gene expression, oxidative stress and DNA damage accumulation in blood mononuclear cells of 9 healthy controls, coupled with effective anti-SARS-CoV-2 neutralizing antibody production in all. Increased DNA damage after SARS-CoV-2 vaccine, partly due to increased oxidative stress, was transient, whereas the inherent...
Source: Clinical Immunology - June 5, 2021 Category: Allergy & Immunology Authors: Panagiotis A Ntouros Nikolaos I Vlachogiannis Maria Pappa Adrianos Nezos Clio P Mavragani Maria G Tektonidou Vassilis L Souliotis Petros P Sfikakis Source Type: research

Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus
Clin Immunol. 2021 Jun 2;229:108764. doi: 10.1016/j.clim.2021.108764. Online ahead of print.ABSTRACTC57BL/6 mice with pristane-induced lupus develop macrophage-dependent diffuse alveolar hemorrhage (DAH), which is blocked by treatment with liver X receptor (LXR) agonists and is exacerbated by low IL-10 levels. Serp-1, a myxomavirus-encoded serpin that impairs macrophage activation and plasminogen activation, blocks DAH caused by MHV68 infection. We investigated whether Serp-1 also could block DAH in pristane-induced lupus. Pristane-induced DAH was prevented by treatment with recombinant Serp-1 and macrophages from Serp1-tr...
Source: Clinical Immunology - June 5, 2021 Category: Allergy & Immunology Authors: Haoyang Zhuang Shuhong Han Li Lu Westley H Reeves Source Type: research

Effective DNA damage response after acute but not chronic immune challenge: SARS-CoV-2 vaccine versus Systemic Lupus Erythematosus
Clin Immunol. 2021 Jun 2:108765. doi: 10.1016/j.clim.2021.108765. Online ahead of print.ABSTRACTWhether and how an acute immune challenge may affect DNA Damage Response (DDR) is unknown. By studying vaccinations against Influenza and SARS-CoV-2 (mRNA-based) we found acute increases of type-I interferon-inducible gene expression, oxidative stress and DNA damage accumulation in blood mononuclear cells of 9 healthy controls, coupled with effective anti-SARS-CoV-2 neutralizing antibody production in all. Increased DNA damage after SARS-CoV-2 vaccine, partly due to increased oxidative stress, was transient, whereas the inherent...
Source: Clinical Immunology - June 5, 2021 Category: Allergy & Immunology Authors: Panagiotis A Ntouros Nikolaos I Vlachogiannis Maria Pappa Adrianos Nezos Clio P Mavragani Maria G Tektonidou Vassilis L Souliotis Petros P Sfikakis Source Type: research

Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus
Clin Immunol. 2021 Jun 2:108764. doi: 10.1016/j.clim.2021.108764. Online ahead of print.ABSTRACTC57BL/6 mice with pristane-induced lupus develop macrophage-dependent diffuse alveolar hemorrhage (DAH), which is blocked by treatment with liver X receptor (LXR) agonists and is exacerbated by low IL-10 levels. Serp-1, a myxomavirus-encoded serpin that impairs macrophage activation and plasminogen activation, blocks DAH caused by MHV68 infection. We investigated whether Serp-1 also could block DAH in pristane-induced lupus. Pristane-induced DAH was prevented by treatment with recombinant Serp-1 and macrophages from Serp1-treate...
Source: Clinical Immunology - June 5, 2021 Category: Allergy & Immunology Authors: Haoyang Zhuang Shuhong Han Li Lu Westley H Reeves Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13;228:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples wer...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13;228:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13;228:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples wer...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13;228:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13;228:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples wer...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13;228:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13;228:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples wer...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13;228:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13;228:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples wer...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13;228:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13;228:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13;228:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an adult patient with mild autoimmune lymphoproliferative syndrome (ALPS)
Clin Immunol. 2021 May 13:108757. doi: 10.1016/j.clim.2021.108757. Online ahead of print.NO ABSTRACTPMID:33992756 | DOI:10.1016/j.clim.2021.108757 (Source: Clinical Immunology)
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Giulio Tessarin Cinzia Mazza Manuela Baronio Luisa Gazzurelli Stefano Rossi Daniele Moratto Raffaele Badolato Anne Rensing-Ehl Stephan Ehl Klaus Warnatz Carlo Rosanelli Enrico Morello Alessandro Plebani Vassilios Lougaris Source Type: research

DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clin Immunol. 2021 May 13:108756. doi: 10.1016/j.clim.2021.108756. Online ahead of print.ABSTRACTScleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS) compared to matched healthy controls. Genome-wide DNA methylation changes in peripheral blood mononuclear cell samples were as...
Source: Clinical Immunology - May 16, 2021 Category: Allergy & Immunology Authors: Patrick Coit Kaila L Schollaert Emily M Mirizio Kathryn S Torok Amr H Sawalha Source Type: research