A family history of SCID and unrevealing WES: An approach to management and guidance of patients.
We describe how Sanger sequencing of parents was used to study the genomic regions that were poorly covered by WES, and how immune phenotyping results were used in the setting of genetic counseling. PMID: 32629161 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - July 3, 2020 Category: Allergy & Immunology Authors: Mehawej C, Khayat CD, Hamdan N, Chouery E, Platt CD Tags: Clin Immunol Source Type: research

Editorial: Psoriatic arthritis; overcoming the challenges by creating opportunities.
PMID: 32621978 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - July 1, 2020 Category: Allergy & Immunology Authors: Bell S, Nahle Z, Adamopoulos IE Tags: Clin Immunol Source Type: research

The IL-2 - IL-2 receptor pathway in health and disease: the role of the soluble IL-2 receptor.
Abstract The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is ...
Source: Clinical Immunology - June 30, 2020 Category: Allergy & Immunology Authors: Damoiseaux J Tags: Clin Immunol Source Type: research

Activated double-negative T cells (CD3+CD4-CD8-HLA-DR+) define response to renal denervation for resistant hypertension.
CONCLUSIONS: 'Responders' significantly present with lower absolute values of activated DN T cells and have lower and more stable values of total T CD8+, CD4+, and naïve T CD8+ cells. These cell types may be able to predict response to RDN. PMID: 32619647 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 30, 2020 Category: Allergy & Immunology Authors: Silva JD, Almeida JS, Rodrigues-Santos P, Rosa MS, Gonçalves L Tags: Clin Immunol Source Type: research

Imatinib for COVID-19: A case report.
iz-Ruiz J, Martín-López JVS PMID: 32599278 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 26, 2020 Category: Allergy & Immunology Authors: Morales-Ortega A, Bernal-Bello D, Llarena-Barroso C, Frutos-Pérez B, Duarte-Millán MÁ, de Viedma-García VG, Farfán-Sedano AI, Canalejo-Castrillero E, Ruiz-Giardin JM, Ruiz-Ruiz J, Martín-López JVS Tags: Clin Immunol Source Type: research

Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment.
Abstract Approximately 15% of patients with coronavirus disease 2019 (COVID-19) experience severe disease, and 5% progress to critical stage that can result in rapid death. No vaccines or antiviral treatments have yet proven effective against COVID-19. Patients with severe COVID-19 experience elevated plasma levels of pro-inflammatory cytokines, which can result in cytokine storm, followed by massive immune cell infiltration into the lungs leading to alveolar damage, decreased lung function, and rapid progression to death. As many of the elevated cytokines signal through Janus kinase (JAK)1/JAK2, inhibition of the...
Source: Clinical Immunology - June 22, 2020 Category: Allergy & Immunology Authors: Yeleswaram S, Smith P, Burn T, Covington M, Juvekar A, Li Y, Squier P, Langmuir P Tags: Clin Immunol Source Type: research

COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential.
CONCLUSIONS: As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8+ T and NK cells. GrA+CD8+ T and perforin+ NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19. PMID: 32574709 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 20, 2020 Category: Allergy & Immunology Authors: Jiang Y, Wei X, Guan J, Qin S, Wang Z, Lu H, Qian J, Wu L, Chen Y, Chen Y, Lin X Tags: Clin Immunol Source Type: research

Psoriatic arthritis under the influence of IFN γ.
Psoriatic arthritis under the influence of IFNγ. Clin Immunol. 2020 Jun 20;:108513 Authors: Dai H, Adamopoulos IE Abstract Psoriasis is a common multifactorial autoimmune disease of the skin, and in a large percentage of patients, immune responses involve nail and joint pathology, which develop psoriatic arthritis (PsA). Historically, T helper 1 (Th1)-derived-IFN-γ was abundantly detected in psoriatic skin and its correlation with development and severity of PsO, led to an early classification of psoriasis as a Th1-mediated disease. Investigations of the cellular and molecular mechanisms o...
Source: Clinical Immunology - June 20, 2020 Category: Allergy & Immunology Authors: Dai H, Adamopoulos IE Tags: Clin Immunol Source Type: research

Allergic skin inflammation and S. aureus skin colonization are mutually reinforcing.
Abstract Atopic dermatitis (AD) lesional skin is often colonized with S. aureus, and the load of S. aureus correlates with disease severity. However, a causative and mechanistic link between S. aureus skin colonization and severity of AD is not well established. We made use of well-established mouse model of AD elicited by epicutaneous sensitization of tape stripped skin with ovalbumin to investigate the relationship between allergic skin inflammation and cutaneous S. aureus colonization. Topical application of S aureus exacerbated allergic skin inflammation induced by epicutaneous sensitization with ovalbumin, wh...
Source: Clinical Immunology - June 19, 2020 Category: Allergy & Immunology Authors: Leyva-Castillo JM, McGurk A, Raif Geha MD Tags: Clin Immunol Source Type: research

Circulating anti-C3b IgG in lupus nephritis: A large cohort study.
Abstract The current study aimed to analyze the clinical significance and bio-functional properties of anti-C3b IgG based on a lupus nephritis cohort. We found that the prevalence of anti-C3b IgG in our cohort was 47.8%. Patients with positive anti-C3b IgG had significantly higher SLEDAI, lower circulating C3 and C4 levels. Anti-C3b IgG levels were positively correlated with C3 or C1q deposition in kidneys and several active pathological lesions. The positivity of anti-C3b IgG was an independent risk factor for the composite endpoints in the subgroup of proliferative lupus nephritis patients. In vitro, the purifie...
Source: Clinical Immunology - June 18, 2020 Category: Allergy & Immunology Authors: Tao J, Song D, Liu XL, Yu F, Zhao MH Tags: Clin Immunol Source Type: research

Neutralizing natural anti-IL-17F autoantibodies protect Autoimmune Polyendocrine Syndrome Type 1 (APS-1) patients from asthma.
PMID: 32544610 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 13, 2020 Category: Allergy & Immunology Authors: Jokinen M, Edelman S, Krohn K, Kankainen M, Ranki A Tags: Clin Immunol Source Type: research

Development of child immunity in the context of COVID-19 pandemic.
Abstract Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children. PMID: 32544611 [PubMed - as supplied by publ...
Source: Clinical Immunology - June 13, 2020 Category: Allergy & Immunology Authors: Kloc M, Ghobrial RM, Kuchar E, Lewicki S, Kubiak JZ Tags: Clin Immunol Source Type: research

X-linked inhibitor of apoptosis protein deficiency complicated with Crohn's disease-like enterocolitis and Takayasu arteritis: A case report.
Abstract X-linked inhibitor of apoptosis protein (XIAP) deficiency results in monogenic inflammatory bowel disease. To date, no vasculitis associated with XIAP deficiency has been reported. A 10-year-old boy was diagnosed with Crohn's disease and he responded poorly to conventional treatment for Crohn's disease. He was dependent on corticosteroids and parenteral nutrition. To manage severe colitis, he underwent ileostomy followed by ileocolectomy for an ileo-sigmoid fistula. At the age of 15 years, he developed IgA vasculitis and at the age of 17 years, he developed refractory Takayasu arteritis (TAK), which w...
Source: Clinical Immunology - June 12, 2020 Category: Allergy & Immunology Authors: Takeuchi I, Kawai T, Nambu M, Migita O, Yoshimura S, Nishimura K, Yoshioka T, Ogura M, Kyodo R, Shimizu H, Ito S, Kato M, Onodera M, Hata K, Matsubara Y, Arai K Tags: Clin Immunol Source Type: research

Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy.
CONCLUSION: In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE. PMID: 32535188 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 11, 2020 Category: Allergy & Immunology Authors: Fabio C, Antonella C, Patrizia RQ, Francesco C, Annalisa R, Laura G, Caterina C, Rebecca L, Andrea P, Alberto A, Carlo S, Eleonora B, Maria F, Cristina T, Sergio C, Giacomo M, Efgeny F, Stefano F, Marzia S, Carlo M, Michele C, Luigi B, Maria SA, Massimo C Tags: Clin Immunol Source Type: research

IL-27: An endogenous constitutive repressor of human monocytes.
We report here that human monocytes are repressed by endogenous IL-27, in that the addition of an anti-IL-27 neutralizing antibody increases the production of pro-inflammatory cytokines ex vivo. We observed that neutralizing monocyte-derived IL-27 leads to increased IL-17A production by CD4+ T cells and a down-regulation of the IL-17 modulating ectonucleotidase CD39 on monocytes. The locus that contains the IL27 gene has been linked to susceptibility for type 1 diabetes (T1D). Interestingly, ex vivo monocytes from subjects with T1D produce more IL-27 suggesting this upregulation of IL-27 acts as a negative feedback loop to...
Source: Clinical Immunology - June 9, 2020 Category: Allergy & Immunology Authors: Frangieh M, McHenry A, Phillips R, Ye C, Bernier A, Laffell L, Elyaman W, Bradshaw EM Tags: Clin Immunol Source Type: research

Sicca syndrome following immune checkpoint inhibition.
Abstract The recent approval of Immunologic checkpoint inhibitors as an effective therapeutic strategy against cancer came at the cost of toxicities mediated by an excessive activation of immune system against health tissues, including among others musculoskeletal and sicca complaints.The latter occur in the context of an entity reminiscent of Sjogren's syndrome, with distinct characteristics such as abrupt onset, male predominance, lower prevalence of autoantibodies and response to steroids. PMID: 32531346 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 9, 2020 Category: Allergy & Immunology Authors: Mavragani CP, Moutsopoulos HM Tags: Clin Immunol Source Type: research

Circulating Th1/17 cells serve as a biomarker of disease severity and a target for early intervention in AChR-MG patients.
Abstract Interleukin-17-expressing CD4+ T helper 17 (Th17) cells are considered to be critical regulators of thymic inflammation in AChR-MG patients. However, Th17 cells are functionally heterogeneous and circulating Th17 subsets are incompletely understood in AChR-MG patients. Here, we studied characteristics of Th17 subsets in peripheral blood from treatment-naïve AChR-MG patients, patients treated with immunosuppressants, as well as healthy controls. We found increased frequencies of circulating Th1-like Th17 (Th1/17) (IFN-γ + IL-17 + CD4 + CD3+) cells, which declined earlier than convent...
Source: Clinical Immunology - June 8, 2020 Category: Allergy & Immunology Authors: Ma Q, Ran H, Li Y, Lu Y, Liu X, Huang H, Yang W, Yu L, Chen P, Huang X, Qiu L, Lin Z, Ou C, Liu W Tags: Clin Immunol Source Type: research

Antibody-dependent enhancement and COVID-19: Moving toward acquittal.
PMID: 32526272 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 8, 2020 Category: Allergy & Immunology Authors: Yager EJ Tags: Clin Immunol Source Type: research

A plea for the pathogenic role of immune complexes in severe Covid-19.
aud P PMID: 32526273 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 8, 2020 Category: Allergy & Immunology Authors: Vuitton DA, Vuitton L, Seillès E, Galanaud P Tags: Clin Immunol Source Type: research

Immune competence and respiratory symptoms in patients with ataxia telangiectasia: A prospective follow-up study.
CONCLUSIONS: Mild symptoms like chronic cough were present in A-T patients, possibly indicating ongoing silent crippling disease. PMID: 32504779 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - June 3, 2020 Category: Allergy & Immunology Authors: Wölke S, Donath H, Bakhtiar S, Trischler J, Schubert R, Zielen S Tags: Clin Immunol Source Type: research

SAP interacts with CD28 to inhibit PD-1 signaling in T lymphocytes.
Abstract T cell co-stimulation is important for the maintenance of immunologic tolerance. Co-inhibitory receptors including programmed cell death-1 (PD-1) confer peripheral tolerance to prevent autoimmunity. SAP (SH2D1A) is an adaptor molecule that is important in T cell signaling and has been shown to interact with signaling lymphocytic activation molecule (SLAM) family receptors also in the context of self-tolerance. We recently reported that SAP interferes with PD-1 function. In the current study, we investigated the levels of SAP and PD-1 in patients with rheumatoid arthritis (RA) to further understand what ro...
Source: Clinical Immunology - June 3, 2020 Category: Allergy & Immunology Authors: Sandigursky S, Philips M, Mor A Tags: Clin Immunol Source Type: research

Treating COVID-19 with colchicine in community healthcare setting.
PMID: 32492478 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 31, 2020 Category: Allergy & Immunology Authors: Della-Torre E, Della-Torre F, Kusanovic Pcp M, Scotti R, Alvise-Ramirez G, Dagna L, Tresoldi M Tags: Clin Immunol Source Type: research

Circulating cells and exosomes in acute myelogenous leukemia and their role in disease progression and survival.
Abstract Acute myelogenous leukemia (AML) is an aggressive hematological malignancy associated with high rates of mortality. This incidence is due to the complexity in which the AML cells interact with other healthy human cells. These phenomena create an environment that favors the expansion of leukemic cells, which will affect the patient's prognosis. An important aspect is the ability of AML cells to evade immune responses via targeting and signaling immune cells to suppress anti-tumor responses. Many studies have reported that associations among components in the peripheral bloodstream might modulate leukemic p...
Source: Clinical Immunology - May 31, 2020 Category: Allergy & Immunology Authors: Miyamoto KN, Bonatto D Tags: Clin Immunol Source Type: research

IL-21+ CD4+ T helper cells co-expressing IFN- γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis.
IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis. Clin Immunol. 2020 May 30;:108484 Authors: Fischer J, Dirks J, Haase G, Holl-Wieden A, Hofmann C, Girschick H, Morbach H Abstract Juvenile Idiopathic Arthritis (JIA) is currently classified into seven subgroups. Recently, antinuclear antibody (ANA) positive JIA patients were suggested to encompass a clinically homogenous new subgroup. CD4+ T helper (Th) cells play an essential role in JIA pathogenesis. Herein, we analyzed cytokine e...
Source: Clinical Immunology - May 30, 2020 Category: Allergy & Immunology Authors: Fischer J, Dirks J, Haase G, Holl-Wieden A, Hofmann C, Girschick H, Morbach H Tags: Clin Immunol Source Type: research

Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients.
nas I Abstract The lymphopenia exhibited in patients with COVID-19 has been associated with a worse prognosis in the development of the disease. To understand the factors associated with a worse evolution of COVID-19, we analyzed comorbidities, indicators of inflammation such as CRP and the ratio of neutrophils/lymphocytes, as well as the count of blood cells with T-lymphocyte subtypes in 172 hospitalized patients with COVID-19 pneumonia. Patients were grouped according to their needs for mechanical ventilation (ICU care) or not. Within the comorbidities studied, obesity was the only associated with greater severi...
Source: Clinical Immunology - May 29, 2020 Category: Allergy & Immunology Authors: Urra JM, Cabrera CM, Porras L, Ródenas I Tags: Clin Immunol Source Type: research

Type 3 hypersensitivity in COVID-19 vasculitis.
Abstract Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden around the world. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release s...
Source: Clinical Immunology - May 29, 2020 Category: Allergy & Immunology Authors: Roncati L, Ligabue G, Fabbiani L, Malagoli C, Gallo G, Lusenti B, Nasillo V, Manenti A, Maiorana A Tags: Clin Immunol Source Type: research

Immunoglobulin free light chains as an inflammatory biomarker of heart failure with myocarditis.
CONCLUSIONS: This study suggests that FLC kappa/lambda ratio is a promising biomarker of heart failure with myocarditis. PMID: 32479987 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 29, 2020 Category: Allergy & Immunology Authors: Matsumori A, Shimada T, Nakatani E, Shimada M, Tracy S, Chapman NM, Drayson MT, Hartz VL, Mason JW Tags: Clin Immunol Source Type: research

B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease.
Abstract B-cell clonal expansion has been sporadically described in the blood and/or renal tissue of patients with glomerulonephritides, albeit with unclear pathogenetic role. Herein, using spectratyping analysis, we observed oligoclonal intrarenal B-cell populations in 59% of glomerulonephritis patients with podocyte injury (6/7 with focal segmental glomerulosclerosis, 1/3 minimal change disease, 1/3 idiopathic membranous nephropathy, 3/4 IgA nephropathy, 2/5 membranous lupus nephritis), 20% of glomerulonephritis patients without podocyte involvement (4/13 with mesangial or proliferative lupus nephritis, 0/3 idio...
Source: Clinical Immunology - May 29, 2020 Category: Allergy & Immunology Authors: Kolovou K, Laskari K, Roumelioti M, Tektonidou M, Panayiotidis P, Boletis JN, Marinaki S, Sfikakis PP Tags: Clin Immunol Source Type: research

Immunostaining of galactose-deficient IgA1 by KM55 is not specific for immunoglobulin A nephropathy.
CONCLUSIONS: Immunostaining for Gd-IgA1 by KM55 is not specific for IgA nephropathy, but weak or negative staining may favor incidental IgA deposits. PMID: 32479989 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 29, 2020 Category: Allergy & Immunology Authors: Zhao L, Peng L, Yang D, Chen S, Lan Z, Zhu X, Yuan S, Chen G, Liu Y, Liu H Tags: Clin Immunol Source Type: research

Expression pattern of the interferon regulatory factor family members in influenza virus induced local and systemic inflammatory responses.
In this study, we found that all members of IRF family responded to influenza virus. The IRF family expression profile seems to be related to the pathogenicity of the particular influenza virus strain. The influenza virus mainly relies on endosomal TLR signals and the positive feedback loop of IFN-I to cause either direct or indirect different expression of all IRF family members locally or systemically. Interestingly, IRF6 was somewhat different from other IRF family members during influenza virus infection. Overall, the expression profile of the IRF family may be a valuable reference for the prevention and treatment of i...
Source: Clinical Immunology - May 29, 2020 Category: Allergy & Immunology Authors: Tuerxun W, Wang Y, Cui C, Yang L, Wang S, Yu Y, Wang L Tags: Clin Immunol Source Type: research

Not your average joint: Towards precision medicine in psoriatic arthritis.
We describe the applications of precision medicine in risk stratification, drug selection, and treatment response prediction in psoriatic arthritis, for which targeted, personalized approaches are steadily emerging. PMID: 32473975 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 28, 2020 Category: Allergy & Immunology Authors: Castillo R, Scher JU Tags: Clin Immunol Source Type: research

Racial disparity in Covid-19 mortality rates - A plausible explanation.
PMID: 32473354 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 27, 2020 Category: Allergy & Immunology Authors: Tal Y, Adini A, Eran A, Adini I Tags: Clin Immunol Source Type: research

HLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patients.
A, Moreau P Abstract Chronic hepatitis C virus (HCV) infection induces liver damage and the HCV/ Human Immunodeficiency Virus (HIV)-coinfection may further contribute to its progression. The HLA-G molecule inhibits innate and adaptive immunity and may be deleterious for chronically virus-infected cells. We studied 204 HCV-mono-infected patients, 142 HCV/HIV-coinfected patients, 104 HIV-mono-infected patients and 163 healthy subjects. HLA-G liver expression was similarly induced in HCV and HCV/HIV specimens, increasing with advanced fibrosis and necroinflammatory activity, and with increased levels of liver functio...
Source: Clinical Immunology - May 26, 2020 Category: Allergy & Immunology Authors: Bertol BC, Dias FC, Debortoli G, Souto BM, Mendonça PB, Araújo RC, Santana RC, Ramalho LNZ, Castelli EC, de Lourdes Candolo Martinelli A, Mendes-Junior CT, Carosella ED, Donadi EA, Moreau P Tags: Clin Immunol Source Type: research

Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI).
h H Abstract STING-associated vasculopathy with onset in infancy (SAVI) is an autoimmune disease caused by heterozygous gain of function mutations of STING (stimulator of interferon genes) that had initially been classified as a type I interferonopathy. We recently reported a genetically engineered mouse strain carrying a common SAVI-associated STING mutation. These STING N153S/WT mice reproduce key features of SAVI, including lung inflammation, loss of T cells in spleen and blood, splenomegaly and thymic hypoplasia. Here we show that αβ T lymphocytopenia is due to disrupted T cell development and is as...
Source: Clinical Immunology - May 26, 2020 Category: Allergy & Immunology Authors: Siedel H, Roers A, Rösen-Wolff A, Luksch H Tags: Clin Immunol Source Type: research

Potential of immunotherapies in the mediation of antileukemic responses for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) - With a focus on Dendritic cells of leukemic origin (DCleu).
Abstract New (non-immunotherapeutic) treatment-strategies for AML/MDS-patients are under development. DC and 'leukemia-derived DC' (DCleu) connect the innate and the adaptive immunesystem and (re-)activate it, in their capacity as professional antigen-presenting cells (APCs). They can be generated ex vivo from mononuclear (MNC)-cell fractions or whole blood (WB), containing the -physiological-cellular/soluble microenvironment of individual patients using various DC-generating methods or (for WB) minimalized 'kits', containing granulocyte-macrophage-colony-stimulating-factor (GM-CSF) and a second response-modifier....
Source: Clinical Immunology - May 25, 2020 Category: Allergy & Immunology Authors: Ansprenger C, Amberger DC, Schmetzer HM Tags: Clin Immunol Source Type: research

Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases.
PMID: 32461193 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 24, 2020 Category: Allergy & Immunology Authors: Vojdani A, Kharrazianb D Tags: Clin Immunol Source Type: research

Retraction notice to "Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model" [Clin. Immunol. 201 (2019) 35-47].
Retraction notice to "Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model" [Clin. Immunol. 201 (2019) 35-47]. Clin Immunol. 2020 May 21;:108460 Authors: Wang J, Sui RX, Miao Q, Wang Q, Song LJ, Yu JZ, Li YH, Xiao BG, Cun-GenMa PMID: 32448554 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 21, 2020 Category: Allergy & Immunology Authors: Wang J, Sui RX, Miao Q, Wang Q, Song LJ, Yu JZ, Li YH, Xiao BG, Cun-GenMa Tags: Clin Immunol Source Type: research

Can Ticagrelor be used to prevent sepsis-induced coagulopathy in COVID-19?
PMID: 32445671 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 20, 2020 Category: Allergy & Immunology Authors: Omarjee L, Meilhac O, Perrot F, Janin A, Mahe G Tags: Clin Immunol Source Type: research

Supplements for COVID-19: A modifiable environmental risk.
PMID: 32417594 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 14, 2020 Category: Allergy & Immunology Authors: Young TK, Zampella JG Tags: Clin Immunol Source Type: research

Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.
PMID: 32405269 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 13, 2020 Category: Allergy & Immunology Authors: Omarjee L, Janin A, Perrot F, Laviolle B, Meilhac O, Mahe G Tags: Clin Immunol Source Type: research

Chronic non-bacterial osteomyelitis and autoinflammatory bone diseases.
PMID: 32389739 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - May 7, 2020 Category: Allergy & Immunology Authors: Zhao Y, Ferguson PJ Tags: Clin Immunol Source Type: research

A phase I study of loco-regional immunotherapy by transbronchial injection of α-galactosylceramide-pulsed antigen presenting cells in patients with lung cancer.
A phase I study of loco-regional immunotherapy by transbronchial injection of α-galactosylceramide-pulsed antigen presenting cells in patients with lung cancer. Clin Immunol. 2020 May 06;:108457 Authors: Ishibashi F, Sakairi Y, Iwata T, Moriya Y, Mizobuchi T, Hoshino H, Yoshida S, Hanaoka H, Yoshino I, Motohashi S Abstract We conducted a phase I study of the trans-bronchial injection of α-galactosylceramide (αGalCer)-pulsed antigen presenting cells (APCs) to evaluate their safety, immune responses, and anti-tumor activities. Patients with advanced or recurrent non-small cell lung can...
Source: Clinical Immunology - May 6, 2020 Category: Allergy & Immunology Authors: Ishibashi F, Sakairi Y, Iwata T, Moriya Y, Mizobuchi T, Hoshino H, Yoshida S, Hanaoka H, Yoshino I, Motohashi S Tags: Clin Immunol Source Type: research

Significance of KIR like natural killer cell receptors in autoimmune disorders.
Abstract Killer cell immunoglobulin-like receptors (KIRs), act as the regulators for the cytolytic activity of natural killer and certain T cells by interacting with the HLA class I ligands. KIRs have been shown to contribute to the pathogenesis of several autoimmune diseases. However, their specific roles are still not very clear. Autoimmune diseases are multifactorial in nature, highlighting the influence of both genetic and environmental factors. The innate immune response plays an important role in autoimmunity as it alters the self-glycans that mimic molecular patterns found on different intracellular pathoge...
Source: Clinical Immunology - May 3, 2020 Category: Allergy & Immunology Authors: Agrawal S, Prakash S Tags: Clin Immunol Source Type: research

Circulating dendritic cells are severely decreased in idiopathic pulmonary fibrosis with a potential value for prognosis prediction.
Abstract Dendritic cells (DCs) accumulate in the lung of patients affected by idiopathic pulmonary fibrosis (IPF). We measured the frequencies of circulating conventional CD1c + and CD141+ cells (namely, cDC2 and cDC1) and of plasmacytoid CD303+ DCs in a cohort of 60 therapy naive IPF patients by flow cytometry. Peripheral levels of reactive oxygen species (ROS) and of pro-inflammatory and Th1/Th2 polarizing cytokines were also analyzed. All blood DC subtypes were significantly reduced in IPF patients in comparison to age- and sex-matched controls, while ROS and interleukin (IL-6) levels were augmented. IL-6 e...
Source: Clinical Immunology - May 3, 2020 Category: Allergy & Immunology Authors: Galati D, Zanotta S, Polistina GE, Coppola A, Capitelli L, Bocchino M Tags: Clin Immunol Source Type: research

Generation of high-affinity CMV-specific T cells for adoptive immunotherapy using IL-2, IL-15, and IL-21.
Abstract Cytomegalovirus (CMV) infection remains a life-threatening condition in individuals with a suppressed immune system. CMV may also represent a clinically relevant target for immune responses in CMV-positive malignancies. We established a protocol to expand CMV-specific T cells (CMV-T) using peripheral blood mononuclear cells (PBMCs). PBMCs from 16 HLA-A*0201 donors were cultured with a cytokine cocktail comprising IL-2/IL-15/IL-21 along with overlapping peptides from CMV-pp65. Ten days later, T cells were stimulated with anti-CD3 (OKT3) and irradiated autologous PBMCs. CMV-T were detected by HLA-A*0201 CMV...
Source: Clinical Immunology - May 3, 2020 Category: Allergy & Immunology Authors: Luo XH, Meng Q, Liu Z, Paraschoudi G Tags: Clin Immunol Source Type: research

Biosimilars in pediatric rheumatology and their introduction into routine care.
Abstract Biosimilars are biologic medications that are slightly altered versions of already approved biologic disease modifying anti-rheumatic drugs (bDMARDs). They can be manufactured after the original product's patent protection expires. The advent of biosimilar use in pediatric rheumatology started with the biosimilar to infliximab in 2013. Since then, more biosimilars have been made available including etanercept, rituximab and adalimumab. This manuscript briefly reviews the history of biosimilar introduction to treatment and suggests strategies for the adoption of biosimilar drugs in services specialized in ...
Source: Clinical Immunology - April 30, 2020 Category: Allergy & Immunology Authors: Cuevas OA, Hedrich CM Tags: Clin Immunol Source Type: research

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101.
Abstract Acute respiratory distress syndrome (ARDS) is a devastating clinical manifestation of COVID-19 pneumonia and is mainly based on an immune-driven pathology. Mounting evidence suggests that COVID-19 is fueled by a maladaptive host inflammatory response that involves excessive activation of innate immune pathways. While a "cytokine storm" involving IL-6 and other cytokines has been documented, complement C3 activation has been implicated as an initial effector mechanism that exacerbates lung injury in preclinical models of SARS-CoV infection. C3-targeted intervention may provide broader therapeutic...
Source: Clinical Immunology - April 29, 2020 Category: Allergy & Immunology Authors: Mastaglio S, Ruggeri A, Risitano AM, Angelillo P, Yancopoulou D, Mastellos DC, Huber-Lang M, Piemontese S, Assanelli A, Garlanda C, Lambris JD, Ciceri F Tags: Clin Immunol Source Type: research

DNMT3B deficiency presenting as severe combined immune deficiency: A case report.
Abstract Immunodeficiency, Centromeric instability and Facial anomalies (ICF) syndrome is a group of rare autosomal recessive disorders. The immune disease in the ICF syndrome consists mainly of humoral immunodeficiency. T-cell dysfunction has previously been suspected to be part of the syndrome's spectrum. However, patients with ICF display, at a young age, a normal number of T cells that tend to decline throughout disease progression due to apoptosis. Biallelic mutations in the DNMT3B gene account for around 50% of ICF cases (ICF type 1). The remaining half may be linked to ZBTB24, CDCA7 or HELLS. Here we report...
Source: Clinical Immunology - April 29, 2020 Category: Allergy & Immunology Authors: Mehawej C, Khalife H, Hanna-Wakim R, Dbaibo G, Farra C Tags: Clin Immunol Source Type: research

Efficacy of tofacitinib for slowly progressive interstitial lung disease in a patient with anti-MDA5 antibody-positive dermatomyositis.
PMID: 32360518 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - April 29, 2020 Category: Allergy & Immunology Authors: Takatani A, Koga T, Fujita Y, Fukui S, Endo Y, Shimizu T, Kawakami A Tags: Clin Immunol Source Type: research

Dupilumab to treat severe atopic dermatitis in autosomal dominant hyper-IgE syndrome.
PMID: 32360519 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - April 29, 2020 Category: Allergy & Immunology Authors: Sogkas G, Hirsch S, Jablonka A, Witte T, Schmidt RE, Atschekzei F Tags: Clin Immunol Source Type: research