Novel signatures associated with systemic lupus erythematosus clinical response to IFN-alpha/-omega inhibition
CONCLUSIONS: These signatures may enable enrichment for treatment responders when using IFN-I-suppressing treatments in SLE.PMID:33626969 | DOI:10.1177/0961203321995576 (Source: Lupus)
Source: Lupus - February 25, 2021 Category: Rheumatology Authors: Loqmane Seridi Matteo Cesaroni Ashley Orillion Jessica Schreiter Marc Chevrier Stanley Marciniak Thi-Sau Migone William Stohl Walter Winn Chatham Richard Alan Furie Jacqueline Benson Jarrat Jordan Source Type: research

Smoking exposure in pack-years predicts cutaneous manifestations and damage in systemic lupus erythematosus
CONCLUSIONS: Smoking was an independent risk factor for cutaneous SLE. High pack-year exposure and non-White race increased chronic skin manifestations and SDI damage. Findings suggested a dose relationship between smoking and cutaneous SLE damage, making cessation messaging important to potentially improve outcomes and reduce some disparities.PMID:33626970 | DOI:10.1177/0961203321995257 (Source: Lupus)
Source: Lupus - February 25, 2021 Category: Rheumatology Authors: Nnenna Ezeh Trevor McKown Shivani Garg Christie M Bartels Source Type: research

Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic lupus erythematosus on immunosuppressants: A non-concurrent cohort study
Lupus. 2021 Feb 24:961203321995238. doi: 10.1177/0961203321995238. Online ahead of print.ABSTRACTBACKGROUND: Prophylactic trimethoprim-sulfamethoxazole (TMP-SMX) prevents pneumocystis jirovecii infection in SLE on immunosuppression. Its role in preventing other major infections in immuno suppressed SLE patients is unknown.METHODS: A non-concurrent cohort study was conducted on patients of SLE fulfilling SLICC and/or ACR 1997 criteria, who received tapering dose of steroid starting with ≥0.5 mg/kg/day of prednisolone or equivalent dose of deflazacort and mycophenolate mofetil ≥1 g/day (or equivalent dose of mycophenol...
Source: Lupus - February 25, 2021 Category: Rheumatology Authors: Salil A Ganu Ashish J Mathew Ambily Nadaraj L Jeyaseelan Debashish Danda Source Type: research

Distribution of IgG subclass anti-nuclear antibodies (ANAs) in systemic lupus erythematosus
Lupus. 2021 Feb 23:961203321995242. doi: 10.1177/0961203321995242. Online ahead of print.ABSTRACTOBJECTIVES: Our study purpose was to detect the distribution of anti-nuclear antibody (ANA) IgG subclasses in patients with systemic lupus erythematosus (SLE) and to evaluate their influence on the inflammatory process in SLE.METHODS: We determined the serum levels of ANA IgG subclasses from 70 SLE patients, 25 patients with other autoimmune diseases (OAD), and 25 healthy controls using ELISA. The serum level of total ANA IgG and the avidity of ANA IgG, dsDNA IgG, and dsDNA IgG subclasses were analysed by ELISA.RESULTS: The res...
Source: Lupus - February 24, 2021 Category: Rheumatology Authors: Yanli Zeng Yan Zhang Qinggui Chen Qinghe Huang Yiqiang Lin Xuelian Wang Jia Jia Wang Longcan Jiang Yun Xiao Source Type: research

Correlation between the clinical remission and histological remission in repeat biopsy findings of quiescent proliferative lupus nephritis
Lupus. 2021 Feb 20:961203321995251. doi: 10.1177/0961203321995251. Online ahead of print.ABSTRACTBACKGROUND: The optimal duration of maintenance therapy is controversial in proliferative lupus nephritis (LN). Discordance between clinical parameters of renal remission and histological findings has made repeat biopsy a compulsory tool to confirm the histological remission (HR), but the timing is debatable. Aim of this study was to find the correlation of sustained complete clinical remission (CR) in sever lupus nephritis with histological findings on repeat kidney biopsy and appropriate duration of treatment in maintenance p...
Source: Lupus - February 22, 2021 Category: Rheumatology Authors: Uttara Das Ravi Patel Swarnalatha Guditi Gangadhar Taduri Source Type: research

Breastfeeding in women affected by systemic lupus erythematosus: Rate, duration and associated factors
CONCLUSIONS: SLE women didn't show lower breastfeeding rate in comparison with general population but they presented higher prevalence of early discontinuation within three months. Early interruption was positively associated with smoking, BMI, joint involvement; meanwhile disease duration and HCQ treatment during postpartum were positively associated with a longer breastfeeding duration.PMID:33611966 | DOI:10.1177/0961203321995263 (Source: Lupus)
Source: Lupus - February 22, 2021 Category: Rheumatology Authors: Valeria Orefice Fulvia Ceccarelli Carmelo Pirone Paola Galoppi Francesca Romana Spinelli Cristiano Alessandri Roberto Brunelli Giuseppina Perrone Fabrizio Conti Source Type: research

Correlation between the clinical remission and histological remission in repeat biopsy findings of quiescent proliferative lupus nephritis
Lupus. 2021 Feb 20:961203321995251. doi: 10.1177/0961203321995251. Online ahead of print.ABSTRACTBACKGROUND: The optimal duration of maintenance therapy is controversial in proliferative lupus nephritis (LN). Discordance between clinical parameters of renal remission and histological findings has made repeat biopsy a compulsory tool to confirm the histological remission (HR), but the timing is debatable. Aim of this study was to find the correlation of sustained complete clinical remission (CR) in sever lupus nephritis with histological findings on repeat kidney biopsy and appropriate duration of treatment in maintenance p...
Source: Lupus - February 22, 2021 Category: Rheumatology Authors: Uttara Das Ravi Patel Swarnalatha Guditi Gangadhar Taduri Source Type: research

Breastfeeding in women affected by systemic lupus erythematosus: Rate, duration and associated factors
CONCLUSIONS: SLE women didn't show lower breastfeeding rate in comparison with general population but they presented higher prevalence of early discontinuation within three months. Early interruption was positively associated with smoking, BMI, joint involvement; meanwhile disease duration and HCQ treatment during postpartum were positively associated with a longer breastfeeding duration.PMID:33611966 | DOI:10.1177/0961203321995263 (Source: Lupus)
Source: Lupus - February 22, 2021 Category: Rheumatology Authors: Valeria Orefice Fulvia Ceccarelli Carmelo Pirone Paola Galoppi Francesca Romana Spinelli Cristiano Alessandri Roberto Brunelli Giuseppina Perrone Fabrizio Conti Source Type: research

'Black and white and every wrong colour': The medical history of Jane Austen and the possibility of systemic lupus erythematosus
Lupus. 2021 Feb 17:961203321995260. doi: 10.1177/0961203321995260. Online ahead of print.ABSTRACTJane Austen died 200 years ago at the age of 41 and authors have attributed her premature death to a wide variety of causes, which include Addison's disease and lymphoma.We have reviewed all of her available letters and extricated relevant medical information which reveal rheumatism, facial skin lesions, fever and marked fluctuation of these symptoms. The severity of these symptoms increased, leading to her death within a year.This range of clinical features fulfils the most recent classification criteria for systemic lupus ery...
Source: Lupus - February 18, 2021 Category: Rheumatology Authors: Michael D Sanders Elizabeth M Graham Source Type: research

New insights in gut-liver axis in wild-type murine imiquimod-induced lupus
CONCLUSION: This study is the first to demonstrate early fecal calprotectin increase and liver activation of TLR4- NFκB pathway in wild-type murine imiquimod-induced lupus.PMID:33596715 | DOI:10.1177/0961203321995254 (Source: Lupus)
Source: Lupus - February 18, 2021 Category: Rheumatology Authors: Georges Maalouly Joelle Hajal Charbel Noujeim Michel Choueiry Hussein Nassereddine Viviane Smayra Youakim Saliba Nassim Fares Source Type: research

Elevated urinary IL-36gamma in patients with active lupus nephritis and response to treatment
Lupus. 2021 Feb 16:961203321995246. doi: 10.1177/0961203321995246. Online ahead of print.ABSTRACTINTRODUCTION: IL-36 is a new member of the IL-1 family with pro-inflammatory properties. Serum levels of IL-36 are elevated in patients with Systemic Lupus Erythematosus (SLE). However, no data is available on urinary levels of IL-36 in Lupus Nephritis (LN). In psoriasis expression of IL-36 is site specific and expressed in skin. Hence, we studied urinary levels of IL-36 cytokines in SLE patients.METHODS: A total of 196 patients with SLE [97 active LN patients (ALN), 42 inactive LN (ILN) and 57 active lupus patients with no ren...
Source: Lupus - February 17, 2021 Category: Rheumatology Authors: Sanjukta Majumder Pratibha Singh Rudrarpan Chatterjee Sarit Sekhar Pattnaik Amita Aggarwal Source Type: research

Incidence and prevalence of immune thrombocytopenia under the copayment waiver policy for pediatric patients in Korea: Data from the National Health Claims Database
Lupus. 2021 Feb 16:961203321995247. doi: 10.1177/0961203321995247. Online ahead of print.ABSTRACTThe purpose of this study was to investigate the epidemiology of immune thrombocytopenia (ITP) under the copayment waiver policy for pediatric patients in Korea. The data were collected from the National Health Insurance Claims Database of Korea. ITP was identified based on the diagnostic code D69.38 from the Korean Standard Classification of Diseases. Patients between one and 18 years old, who had at least one health insurance claim for ITP as a final diagnosis, from 1 January 2016, to 31 December 2017, were analyzed. Prevalen...
Source: Lupus - February 17, 2021 Category: Rheumatology Authors: Sung-Hoon Park Sang Gyu Kwak Ji Yoon Kim Source Type: research

Clinical manifestations in patients with antiphospholipid antibodies: Beyond thrombosis and pregnancy loss
Lupus. 2021 Feb 16:961203321995248. doi: 10.1177/0961203321995248. Online ahead of print.ABSTRACTThe clinical spectrum of the antiphospholipid syndrome (APS) encompasses additional manifestations other than thrombosis and pregnancy morbidity, which may potentially affect every organ and system. The pathophysiology of APS indeed cannot be explained exclusively by a prothrombotic state and the "extra-criteria" manifestations of the syndrome should be attributed to other mechanisms, such as inflammation, complement and platelet activation. In this case-series, we report patients with uncommon clinical APS presentati...
Source: Lupus - February 17, 2021 Category: Rheumatology Authors: Irene Cecchi Massimo Radin Elena Rubini Silvia G Foddai Alice Barinotti Dario Roccatello Savino Sciascia Source Type: research

Improvement of lupus-associated fatigue with modafinil: Report of two cases
In conclusion, our report demonstrates, for the first time, that MODA treatment is a potential pharmacological treatment option in selected patients with LAF. Clinical trials in SLE are required to confirm our observations.PMID:33588615 | DOI:10.1177/0961203321995252 (Source: Lupus)
Source: Lupus - February 16, 2021 Category: Rheumatology Authors: Peter Korsten Silvia Piantoni Source Type: research

Elevated urinary IL-36 γ in patients with active lupus nephritis and response to treatment.
Elevated urinary IL-36γ in patients with active lupus nephritis and response to treatment. Lupus. 2021 Feb 16;:961203321995246 Authors: Majumder S, Singh P, Chatterjee R, Pattnaik SS, Aggarwal A Abstract INTRODUCTION: IL-36 is a new member of the IL-1 family with pro-inflammatory properties. Serum levels of IL-36 are elevated in patients with Systemic Lupus Erythematosus (SLE). However, no data is available on urinary levels of IL-36 in Lupus Nephritis (LN). In psoriasis expression of IL-36 is site specific and expressed in skin. Hence, we studied urinary levels of IL-36 cytokines in SLE patient...
Source: Lupus - February 16, 2021 Category: Rheumatology Authors: Majumder S, Singh P, Chatterjee R, Pattnaik SS, Aggarwal A Tags: Lupus Source Type: research

Incidence and prevalence of immune thrombocytopenia under the copayment waiver policy for pediatric patients in Korea: Data from the National Health Claims Database.
Abstract The purpose of this study was to investigate the epidemiology of immune thrombocytopenia (ITP) under the copayment waiver policy for pediatric patients in Korea. The data were collected from the National Health Insurance Claims Database of Korea. ITP was identified based on the diagnostic code D69.38 from the Korean Standard Classification of Diseases. Patients between one and 18 years old, who had at least one health insurance claim for ITP as a final diagnosis, from 1 January 2016, to 31 December 2017, were analyzed. Prevalent cases were defined as patients who used, at least one time, any medica...
Source: Lupus - February 16, 2021 Category: Rheumatology Authors: Park SH, Kwak SG, Kim JY Tags: Lupus Source Type: research

Clinical manifestations in patients with antiphospholipid antibodies: Beyond thrombosis and pregnancy loss.
Abstract The clinical spectrum of the antiphospholipid syndrome (APS) encompasses additional manifestations other than thrombosis and pregnancy morbidity, which may potentially affect every organ and system. The pathophysiology of APS indeed cannot be explained exclusively by a prothrombotic state and the "extra-criteria" manifestations of the syndrome should be attributed to other mechanisms, such as inflammation, complement and platelet activation. In this case-series, we report patients with uncommon clinical APS presentations, to highlight relevant peculiarities of the syndrome, potentially paving th...
Source: Lupus - February 16, 2021 Category: Rheumatology Authors: Cecchi I, Radin M, Rubini E, Foddai SG, Barinotti A, Roccatello D, Sciascia S Tags: Lupus Source Type: research

Improvement of lupus-associated fatigue with modafinil: Report of two cases.
In conclusion, our report demonstrates, for the first time, that MODA treatment is a potential pharmacological treatment option in selected patients with LAF. Clinical trials in SLE are required to confirm our observations. PMID: 33588615 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - February 15, 2021 Category: Rheumatology Authors: Korsten P, Piantoni S Tags: Lupus Source Type: research

Cutaneous manifestations of antiphospholipid syndrome.
Abstract Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder in which autoantibodies are produced against a variety of phospholipids and phospholipid-binding proteins. The purpose of this article is to review cutaneous findings in patients with APS diagnosis. An overview regarding prevalence, description, pathogenesis and histopathology, are described for cutaneous manifestations of APS. PMID: 33583236 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - February 14, 2021 Category: Rheumatology Authors: Gomez-Flores M, Herrera-Argaez G, Vazquez-Martinez O, Herz-Ruelas M, Ocampo-Candiani J, Villarreal-Martinez A, Galarza-Delgado DA, Hernandez-Galarza I, Chavez-Alvarez S Tags: Lupus Source Type: research

Subacute cutaneous lupus erythematosus triggered after measles vaccination.
This report presents a case of a previously healthy female patient who developed SCLE after measles vaccination and progressed to SLE and thereby suggests a possible trigger of the disease. PMID: 33573457 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - February 11, 2021 Category: Rheumatology Authors: de Mattos ABN, Garbo Baroni L, Zanotto LL, Furian MEA Tags: Lupus Source Type: research

Association between alcohol intake and the risk of systemic lupus erythematosus: A systematic review and meta-analysis.
Abstract OBJECTIVES: Previous studies have reported inconsistent results on the relationship between alcohol intake and the risk of systemic lupus erythematosus (SLE). Therefore, we conducted a systematic review and meta-analysis to illustrate the potential role of alcohol intake on the progression of SLE. METHODS: An electronic search of the PubMed, EmBase, and the Cochrane library databases was conducted from their inception up to March 2020. Observational studies that investigated the role of alcohol intake on the risk of SLE were eligible for inclusion in this study. The pooled odds ratio (OR) with 95% co...
Source: Lupus - February 8, 2021 Category: Rheumatology Authors: Wang J, Liu J, Pan L, Guo L, Liu C, Yang S Tags: Lupus Source Type: research

Cutaneous, systemic features and laboratory characteristics of late- versus adult-onset systemic lupus erythematosus in 1006 Thai patients.
Abstract BACKGROUND: Age at disease onset may modulate systemic lupus erythematosus (SLE), but its relation to cutaneous/extracutaneous manifestation remains understudied. OBJECTIVE: To compare the cutaneous, systemic features, laboratory characteristics, and disease severity between late- and adult-onset SLE patients. METHODS: Analyses of the cutaneous, systemic involvement, laboratory investigations, SLE disease activity index 2000 (SLEDAI-2K), and disease damage were performed to compare between groups. RESULTS: Of 1006 SLE patients, 740 and 226 had adult- (15-50 years) and late-onset (>...
Source: Lupus - February 7, 2021 Category: Rheumatology Authors: Chanprapaph K, Tubtieng I, Pratumchat N, Thadanipon K, Rattanakaemakorn P, Suchonwanit P Tags: Lupus Source Type: research

Autoantibodies to Annexin A2 and cerebral thrombosis: Insights from a mouse model.
CONCLUSIONS: This study supports the hypothesis that auto-antibodies to ANXA2 are an independent risk factor for cerebral thrombosis. Consequently, we propose screening for anti-ANXA2 antibodies should be more widely used and patients that exhibit the manifestations of APS should be closely monitored by physicians. PMID: 33554716 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - February 7, 2021 Category: Rheumatology Authors: Weiss R, Bushi D, Mindel E, Bitton A, Diesendruck Y, Gera O, Drori T, Zmira O, Aharoni SA, Agmon-Levin N, Kashi O, Benhar I, Golderman V, Orion D, Chapman J, Shavit-Stein E Tags: Lupus Source Type: research

Age differences in secular trends in black-white disparities in mortality from systemic lupus erythematosus among women in the United States from 1988 to 2017.
CONCLUSIONS: Black adults, youths and adolescents had four to seven times higher SLE mortality rates than their white counterparts and the black-white disparities persisted during the past three decades. On the contrast, black women had less than two times higher all-causes mortality rates than their white counterparts and black-white disparities significantly diminish during the past three decades. PMID: 33535903 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - February 3, 2021 Category: Rheumatology Authors: Guo Q, Liang M, Duan J, Zhang L, Kawachi I, Lu TH Tags: Lupus Source Type: research

Bioinformatic analysis of key biomarkers and immune filtration of skin biopsy in discoid lupus erythematosus.
CONCLUSION: This bioinformatic study selected key biomarkers from the contrast between DLE and NC skin samples and is the first research to analyze immune cell filtration in DLE. PMID: 33530816 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - February 2, 2021 Category: Rheumatology Authors: Xiang M, Chen Q, Feng Y, Wang Y, Wang J, Liang J, Xu J Tags: Lupus Source Type: research

Do anti-DFS70 antibodies temper disease activity and progression in SLE?
PMID: 33530817 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - February 2, 2021 Category: Rheumatology Authors: Choi MY, E Clarke A, Fritzler MJ Tags: Lupus Source Type: research

Outcome of clinical and subclinical myocardial injury in systemic lupus erythematosus - A prospective cohort study.
Abstract OBJECTIVES: To determine the outcome of subclinical lupus myocarditis (LM) over twelve months with regards to: mortality; incidence of clinical LM and change in imaging parameters (echocardiography and cardiac magnetic resonance [CMR]). To evaluate the impact of immunosuppression on CMR evidence of myocardial tissue injury. METHODS: SLE patients with and without CMR evidence of myocardial injury (as per 2009 Lake Louise criteria [LLC]) were included. Analysis at baseline and follow-up included: clinical evaluation, laboratory and imaging analyses (echocardiography and CMR). Clinical LM was defined as...
Source: Lupus - February 1, 2021 Category: Rheumatology Authors: du Toit R, Herbst PG, Ackerman C, Pecoraro AJ, Claassen D, Cyster HP, Reuter H, Doubell AF Tags: Lupus Source Type: research

Pediatric systemic lupus erythematosus with lupus anticoagulant hypoprothrombinemia syndrome-A case series with review of literature.
CONCLUSION: High index of suspicion is needed when child with lupus presents with bleeding manifestations for early diagnosis and treatment. PMID: 33509039 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 28, 2021 Category: Rheumatology Authors: Kocheril AP, Vettiyil GI, George AS, Shah S, Geevar T, Dave RG, T SK Tags: Lupus Source Type: research

Self-perceived quality of life of primary antiphospholipid syndrome patients using vitamin K antagonist.
CONCLUSION: Despite the high adherence to treatment and knowledge of VKA therapy, self-perceived HRQOL is poor in patients with PAPS and is mainly affected by VKA therapy. Searching for better treatment options is warranted. PMID: 33509064 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 28, 2021 Category: Rheumatology Authors: de Oliveira Vaz C, de Moraes Mazetto Fonseca B, Nascimento Silva Vasconcelos PE, Brito Bastos L, Cursino MA, Coelho França Quintanilha J, Tripiquia Vechiatto Mesquita GL, Rosa Dos Santos AP, Cardoso Jacintho B, Oliveira JD, Annichino-Bizzachi J, Andrade Tags: Lupus Source Type: research

Acute respiratory distress syndrome and COVID-19 in a child with systemic lupus erythematosus.
We report a case of COVID-19 in a pediatric patient with systemic lupus erythematosus (SLE), who presented with respiratory distress marked by increased work of breathing and low oxygen saturation. Lab tests confirmed COVID-19, and showed lymphocytopenia and elevated markers of inflammation and coagulopathy. Chest X-ray showed bilateral mid-lung opacities, and the patient required intubation early in his disease course. Imaging and clinical findings were consistent with acute respiratory distress syndrome (ARDS) with inflammation. The patient was treated with different combinations of antivirals (hydroxychloroquine and rem...
Source: Lupus - January 28, 2021 Category: Rheumatology Authors: Sukhdeo S, Negroponte E, Rajasekhar H, Gaur S, Horton DB, Malhotra A, Moorthy LN Tags: Lupus Source Type: research

The importance of pregnancy planning in lupus pregnancies.
CONCLUSION: This study identifies pregnancy intention as a potentially modifiable risk factor for poor outcomes in women with lupus. It highlights a unique population of women with lupus at high risk for pregnancy and infant complications: those ambivalent about pregnancy. These women may not be effectively engaging in health behaviors that prevent pregnancy nor those that will prepare for a safe pregnancy. With effective pregnancy planning and contraception guidance, we may decrease their risk for maternal-fetal morbidity and mortality. PMID: 33509066 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 28, 2021 Category: Rheumatology Authors: Rajendran A, Eudy AM, Balevic SJ, Clowse MEB Tags: Lupus Source Type: research

A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group.
Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project. PMID: 33509067 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 28, 2021 Category: Rheumatology Authors: Gómez-Puerta JA, Pons-Estel GJ, Quintana R, Nieto R, Serrano Morales RM, Harvey GB, Wojdyla D, Scolnik M, Funes Soaje C, Alba Moreyra P, Novatti E, Arizpe F, Berbotto GA, González Lucero L, Porta S, Pérez N, Rodriguez AM, Appenzeller S, de Oliveira E S Tags: Lupus Source Type: research

Legionella pneumophila as a cause of cavitary lung disease in systemic lupus erythematous.
We report a case of cavitary pneumonia caused by L. pneumophila in a 64-year-old female patient with SLE. We also highlight reasons why SLE patients are more prone to L. pneumophila infections. The importance of using correct diagnostic methods for recognizing and treating such infections is also discussed, as mistreatment of cavitary lesions in SLE patients with steroid therapy can have fatal outcomes as the infectious process can significantly worsen. PMID: 33497300 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Khokher W, Kesireddy N, Adunse J, Mudiyanselage PH, Iftikhar S, Assaly R Tags: Lupus Source Type: research

Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus.
In this study, we performed a case-control study to explore the association between Period 2 (PER2) gene single nucleotide polymorphisms (SNPs) and the susceptibility of systemic lupus erythematosus (SLE). A total of 492 SLE patients and 493 healthy controls were included. The improved multiple ligase detection reaction (iMLDR) was used for genotyping. The correlations between four SNPs of PER2 (rs10929273, rs11894491, rs36124720, rs934945) and the genetic susceptibility and clinical manifestations of SLE were analyzed. Significant differences were observed in the distributions of allele frequencies and genotype under domi...
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Dan YL, Zhao CN, Mao YM, Wu Q, He YS, Hu YQ, Xiang K, Yang XK, Sam NB, Wu GC, Pan HF Tags: Lupus Source Type: research

Mean platelet volume may not be a marker for disease activity in children with systemic lupus erythematosus.
PMID: 33497302 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Beyan C, Beyan E Tags: Lupus Source Type: research

Hospitalization in patients with systemic lupus erythematosus at Tawam Hospital, United Arab Emirates (UAE): Rates, causes, and factors associated with length of stay.
CONCLUSION: A significant proportion of patients with SLE were hospitalized during their disease course. The hospitalization rate in this study appears to be higher than those reported elsewhere. Disease flare is the leading cause of admission in patients with SLE in this relatively young cohort. Lupus nephritis has been found to be significantly related to longer LOS. Measurements taken to reduce the incidence and severity of flares would likely decrease hospitalization rate and LOS in patients with SLE. PMID: 33497303 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Aldarmaki R, Al Khogali HI, Al Dhanhani AM Tags: Lupus Source Type: research

Routine testing for hyposplenism in a lupus clinic diagnoses; new cases and opportunities for intervention.
PMID: 33497304 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Ko T, Yeo AL, Luu S, Dendle C, Woolley I, Morand E, Hoi A Tags: Lupus Source Type: research

Resolution of huge thrombi in bilateral ventricles caused by severe lupus cardiomyopathy.
Abstract Ventricular thrombus is an uncommon, severe condition with high morbidity and mortality. Simultaneous left and right ventricular thrombi caused by lupus myocardiopathy have not been previously reported in the literature. This case presents a 42-year-old woman who has bilateral ventricular thrombi with reduced left ventricular ejection fraction (35.4%) and acute kidney injury. Pro-brain natriuretic peptide was>35000 pg/mL. Systemic lupus erythematosus was confirmed based on multiorgan injuries including malar rash, anemia, renal injury, positive antinuclear, anti-Smith antibodies, and decreased c...
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Liu X, Lei S, Huang H, Wu Y, Hu ZX Tags: Lupus Source Type: research

Increased cancer risk in patients with cutaneous lupus erythematosus and systemic lupus erythematosus compared with the general population: A Danish nationwide cohort study.
CONCLUSION: The overall risk of cancer was significantly increased in both patients with CLE and SLE. SIRs for hematological, pancreatic and lung cancers were elevated in both groups. Extra awareness of cancer in patients with SLE and patients with CLE should be considered. PMID: 33497306 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Westermann R, Zobbe K, Cordtz R, Haugaard JH, Dreyer L Tags: Lupus Source Type: research

Identification and stratification of systemic lupus erythematosus patients into two transcriptionally distinct clusters based on IFN-I signature.
CONCLUSIONS: Identification of two distinct clusters of patients based on IFN-I signature provided new insights into the heterogeneity of underlying disease pathogenesis of Indian SLE cohort. Importantly, patient within those clusters retain their distinct expression dynamics of IFN-I signature over the time course of one year despite change in disease activity. This study will guide clinicians and researchers while designing future clinical trials on Indian SLE cohort. PMID: 33497307 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 26, 2021 Category: Rheumatology Authors: Shobha V, Mohan A, Malini AV, Chopra P, Karunanithi P, Subramani Thulasingam S, Selvam S, Deyati A, Srivastava R, Basavanthappa S, Lemos N, Sunitha SM, Mazumder Tagore D, Anand A, Pant S, Jayaswal V, Ramarao M, Dudhgaonkar S Tags: Lupus Source Type: research

The effect of smoking on cumulative damage in systemic lupus erythematosus: An incident cohort study.
CONCLUSIONS: In this incident SLE cohort, past or current smoking predicted new SLE damage 4-5 years earlier. After adjustment, current smokers and patients with a pack-year history of>10 years accumulated damage at twice the rate of never smokers. PMID: 33470148 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 20, 2021 Category: Rheumatology Authors: McKown T, Schletzbaum M, Unnithan R, Wang X, Ezeh N, Bartels CM Tags: Lupus Source Type: research

The impact of low muscle function on health-related quality of life in Indonesian women with systemic lupus erythematosus.
Abstract OBJECTIVE: There was no study aimed at evaluating the effect of muscle function on SLE patients' quality of life using the Sarcopenia Quality of Life (SarQoL) questionnaire. METHODS: This cross-sectional study recruited 61 women with SLE consecutively, muscle function was measured with Jamar handheld-dynamometer and 6-meter walk test, HRQoL was measured with Sarcopenia Quality of Life (SarQoL) questionnaire. The cut-off point for low muscle strength (
Source: Lupus - January 20, 2021 Category: Rheumatology Authors: Sumantri S, Rengganis I, Laksmi PW, Hidayat R, Koesnoe S, Shatri H Tags: Lupus Source Type: research

Bilateral finger ischemia due to hand artery thrombosis caused by repeated movements.
var A PMID: 33470150 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 20, 2021 Category: Rheumatology Authors: Perdan Pirkmajer K, Kramarič J, Tomšič M, Hočevar A Tags: Lupus Source Type: research

Ultrasound characterization of the nail bed in patients with systemic lupus erythematosus.
o AC, Silveira LH Abstract OBJECTIVE: To characterize the ultrasound findings of the nail plate and nail bed in systemic lupus erythematosus (SLE) and its association with nail dystrophy. METHODS: Thirty-two SLE patients, 36 patients with osteoarthritis (OA) and 20 healthy individuals were studied. High-frequency linear ultrasound was performed in nails of the second to fifth fingers in all participants. Disease activity (SLEDAI-2K index), accrued organ damage (SLICC/ACR index), autoantibody profile, and Raynaud's phenomenon were also assessed in SLE patients. RESULTS: Nail bed thickness in SLE patients ...
Source: Lupus - January 20, 2021 Category: Rheumatology Authors: Ferrusquia-Toriz D, Hernández-Díaz C, Amezcua-Guerra LM, Ventura-Ríos L, Higuera-Ortiz V, Lozada-Navarro AC, Silveira LH Tags: Lupus Source Type: research

Analysis of trends and causes of death in SLE patients over a 40-years period in a cohort of patients in the United Kingdom.
CONCLUSIONS: This retrospective review shows how epidemiological factors, causes of death and treatment of SLE patients have changed during the last 40 years in the UCLH cohort. PMID: 33472522 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 20, 2021 Category: Rheumatology Authors: Lorenzo-Vizcaya A, Isenberg D Tags: Lupus Source Type: research

Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: A nationwide population-based study.
CONCLUSIONS: The risk and burden of SLE are high among women during their childbearing years. This calls for special attention to this particular population group when allocating health resources. PMID: 33460342 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 18, 2021 Category: Rheumatology Authors: Chung MK, Park JS, Lim H, Lee CH, Lee J Tags: Lupus Source Type: research

Myositis in systemic lupus erythematosus.
CONCLUSION: We found a low incidence of myositis in our SLE cohort. A cluster of variables, particularly non-Caucasian race/ethnicity, arthritis, Raynaud's phenomenon, and anti-Smith antibodies were associated with risk of developing myositis in SLE. These variables may aid clinicians in identifying SLE patients at highest risk for this important complication. PMID: 33461416 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 18, 2021 Category: Rheumatology Authors: Cotton T, Niaki OZ, Zheng B, Pineau CA, Fritzler M, Vinet E, Clarke AE, Bernatsky S Tags: Lupus Source Type: research

Rituximab - The first twenty years.
Abstract It is now two decades since Rituximab was first used in the treatment of patients with systemic lupus erythematosus. There have been many challenges but in spite of failing to meet its primary endpoints in two clinical trials it is widely used for many aspects of lupus, its side-effects and the possibility that combining it with Benlysta may be of value. We also consider the proposal that it may provide a useful initial therapy. In this review, we consider the place of Rituximab in the treatment of lupus and anticipate how developments in fully-humanized anti-CD20 monoclonals may well extend the "the...
Source: Lupus - January 17, 2021 Category: Rheumatology Authors: Leandro M, Isenberg DA Tags: Lupus Source Type: research

When POTS is the tip of the iceberg: Rare cases of dysautonomia as a possible manifestation of another disorder.
CONCLUSION: In rare cases, POTS can present as a possible manifestation of genetic, neoplastic or neurotoxic disorders. Unusual clinical features that fall outside of the typical spectrum of dysautonomia can point toward the presence of another disorder and help guide further diagnostic investigation. PMID: 33459162 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 17, 2021 Category: Rheumatology Authors: Blitshteyn S Tags: Lupus Source Type: research

"Protenuria in SLE: Is it always lupus?"
We report the case of a 23-year-old woman with a 6-year-long history of SLE presenting with proteinuria after a three-year remission on hydroxychloroquine. Kidney histological examination showed alterations inconsistent with lupus nephritis and suggestive of hydroxychloroquine toxicity or Fabry disease. The latter was confirmed by genetic assay. PMID: 33413001 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - January 7, 2021 Category: Rheumatology Authors: Celia AI, Priori R, Cerbelli B, Diomedi-Camassei F, Leuzzi V, Scrivo R, Alessandri C, d'Amati G, Conti F Tags: Lupus Source Type: research