Renal function deterioration is an independent mortality determinant in Koreans diagnosed with lupus nephritis
Lupus. 2021 Oct;30(12):1896-1905. doi: 10.1177/09612033211038823.ABSTRACTOBJECTIVE: To evaluate the predictors of mortality, mortality rate, and causes of death in patients with lupus nephritis (LN) depending on final renal function.METHODS: The cohort included 401 Korean patients diagnosed with LN between 1985 and 2019. We retrospectively analyzed the clinical and laboratory indices, treatment response, and the final renal function. The final renal function was defined by the last stable level of eGFR measured in an out-patient department more than 3 times before death occurred and was categorized into five groups dependi...
Source: Lupus - November 23, 2021 Category: Rheumatology Authors: Howook Jeon Jennifer Lee Ji Hyeon Ju Wan-Uk Kim Sung-Hwan Park Su-Jin Moon Seung-Ki Kwok Source Type: research

Renal function deterioration is an independent mortality determinant in Koreans diagnosed with lupus nephritis
Lupus. 2021 Oct;30(12):1896-1905. doi: 10.1177/09612033211038823.ABSTRACTOBJECTIVE: To evaluate the predictors of mortality, mortality rate, and causes of death in patients with lupus nephritis (LN) depending on final renal function.METHODS: The cohort included 401 Korean patients diagnosed with LN between 1985 and 2019. We retrospectively analyzed the clinical and laboratory indices, treatment response, and the final renal function. The final renal function was defined by the last stable level of eGFR measured in an out-patient department more than 3 times before death occurred and was categorized into five groups dependi...
Source: Lupus - November 23, 2021 Category: Rheumatology Authors: Howook Jeon Jennifer Lee Ji Hyeon Ju Wan-Uk Kim Sung-Hwan Park Su-Jin Moon Seung-Ki Kwok Source Type: research

Renal function deterioration is an independent mortality determinant in Koreans diagnosed with lupus nephritis
Lupus. 2021 Oct;30(12):1896-1905. doi: 10.1177/09612033211038823.ABSTRACTOBJECTIVE: To evaluate the predictors of mortality, mortality rate, and causes of death in patients with lupus nephritis (LN) depending on final renal function.METHODS: The cohort included 401 Korean patients diagnosed with LN between 1985 and 2019. We retrospectively analyzed the clinical and laboratory indices, treatment response, and the final renal function. The final renal function was defined by the last stable level of eGFR measured in an out-patient department more than 3 times before death occurred and was categorized into five groups dependi...
Source: Lupus - November 23, 2021 Category: Rheumatology Authors: Howook Jeon Jennifer Lee Ji Hyeon Ju Wan-Uk Kim Sung-Hwan Park Su-Jin Moon Seung-Ki Kwok Source Type: research

Renal function deterioration is an independent mortality determinant in Koreans diagnosed with lupus nephritis
Lupus. 2021 Oct;30(12):1896-1905. doi: 10.1177/09612033211038823.ABSTRACTOBJECTIVE: To evaluate the predictors of mortality, mortality rate, and causes of death in patients with lupus nephritis (LN) depending on final renal function.METHODS: The cohort included 401 Korean patients diagnosed with LN between 1985 and 2019. We retrospectively analyzed the clinical and laboratory indices, treatment response, and the final renal function. The final renal function was defined by the last stable level of eGFR measured in an out-patient department more than 3 times before death occurred and was categorized into five groups dependi...
Source: Lupus - November 23, 2021 Category: Rheumatology Authors: Howook Jeon Jennifer Lee Ji Hyeon Ju Wan-Uk Kim Sung-Hwan Park Su-Jin Moon Seung-Ki Kwok Source Type: research

Utilization of glucocorticoids among White and Black patients with systemic lupus erythematosus: Observations from the enrollment visit of a prospective registry
Lupus. 2021 Nov 21:9612033211055817. doi: 10.1177/09612033211055817. Online ahead of print.ABSTRACTBACKGROUND: Black patients with systemic lupus erythematosus (SLE) face higher rates of morbidity and mortality compared to White patients. Long-term glucocorticoid use has been associated with worse health outcomes among patients with SLE. We sought to quantify chronic glucocorticoid use among Black and White patients with SLE within a prospective registry.METHODS: Using enrollment data from a registry at a large academic institution, we compared glucocorticoid use among Black and White patients with SLE. Multivariable logis...
Source: Lupus - November 22, 2021 Category: Rheumatology Authors: James K Sullivan Emily A Littlejohn Source Type: research

Premature rupture of membranes - A cause of foetal complications among lupus: A cohort study, systematic review and meta-analysis
CONCLUSIONS: PROM, both at term and preterm, occurs more frequently in women with lupus than in the general population. A history of serositis, anti-RN, infections and immunosuppression during pregnancy may increase the susceptibility to PROM. The systematic review did not find any study with the main objective of evaluating PROM/PPROM in women with lupus.PMID:34806483 | DOI:10.1177/09612033211045056 (Source: Lupus)
Source: Lupus - November 22, 2021 Category: Rheumatology Authors: Fl ávia Cunha Dos Santos Marcela Lacerda Ignacchiti Bruna Rodrigues Luis Guillermo Velarde Roger Abramino Levy Guilherme Ramires de Jes ús Nilson Ramires de Jes ús Carlos Augusto Ferreira de Andrade Evandro Mendes Klumb Source Type: research

Health-Related Quality of Life and fatigue are associated with a higher work productivity impairment in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort
Conclusion: A poor HRQoL and higher levels of fatigue were associated with a higher percentage of absenteeism, presenteeism, and overall work impairment in SLE patients.PMID:34806488 | DOI:10.1177/09612033211052485 (Source: Lupus)
Source: Lupus - November 22, 2021 Category: Rheumatology Authors: Cristina Reategui-Sokolova Roc ío Violeta Gamboa-Cárdenas Mariela Medina Francisco Zevallos-Miranda Paola Alejandra Ze ña-Huancas Claudia Elera-Fitzcarrald Victor Pimentel-Quiroz Jose Alfaro-Lozano Cesar Pastor-Asurza Risto Perich-Campos Zoila Rodrigue Source Type: research

Utilization of glucocorticoids among White and Black patients with systemic lupus erythematosus: Observations from the enrollment visit of a prospective registry
Lupus. 2021 Nov 21:9612033211055817. doi: 10.1177/09612033211055817. Online ahead of print.ABSTRACTBACKGROUND: Black patients with systemic lupus erythematosus (SLE) face higher rates of morbidity and mortality compared to White patients. Long-term glucocorticoid use has been associated with worse health outcomes among patients with SLE. We sought to quantify chronic glucocorticoid use among Black and White patients with SLE within a prospective registry.METHODS: Using enrollment data from a registry at a large academic institution, we compared glucocorticoid use among Black and White patients with SLE. Multivariable logis...
Source: Lupus - November 22, 2021 Category: Rheumatology Authors: James K Sullivan Emily A Littlejohn Source Type: research

Premature rupture of membranes - A cause of foetal complications among lupus: A cohort study, systematic review and meta-analysis
CONCLUSIONS: PROM, both at term and preterm, occurs more frequently in women with lupus than in the general population. A history of serositis, anti-RN, infections and immunosuppression during pregnancy may increase the susceptibility to PROM. The systematic review did not find any study with the main objective of evaluating PROM/PPROM in women with lupus.PMID:34806483 | DOI:10.1177/09612033211045056 (Source: Lupus)
Source: Lupus - November 22, 2021 Category: Rheumatology Authors: Fl ávia Cunha Dos Santos Marcela Lacerda Ignacchiti Bruna Rodrigues Luis Guillermo Velarde Roger Abramino Levy Guilherme Ramires de Jes ús Nilson Ramires de Jes ús Carlos Augusto Ferreira de Andrade Evandro Mendes Klumb Source Type: research

Health-Related Quality of Life and fatigue are associated with a higher work productivity impairment in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort
Conclusion: A poor HRQoL and higher levels of fatigue were associated with a higher percentage of absenteeism, presenteeism, and overall work impairment in SLE patients.PMID:34806488 | DOI:10.1177/09612033211052485 (Source: Lupus)
Source: Lupus - November 22, 2021 Category: Rheumatology Authors: Cristina Reategui-Sokolova Roc ío Violeta Gamboa-Cárdenas Mariela Medina Francisco Zevallos-Miranda Paola Alejandra Ze ña-Huancas Claudia Elera-Fitzcarrald Victor Pimentel-Quiroz Jose Alfaro-Lozano Cesar Pastor-Asurza Risto Perich-Campos Zoila Rodrigue Source Type: research

Prevalence and risk factors for serositis in patients with systemic lupus erythematosus: A case-control study
CONCLUSION: The overall prevalence of serositis was 9.42%, being significantly higher in men (30%). Therefore, male gender constitutes a risk factor for serositis, and almost one third of men will develop this manifestation, so greater awareness is required in SLE men. CrithidiaDNA+ was also identified as a risk factor, and it should be determined in all SLE patients. Cases significantly received more corticosteroid pulses and higher maximum doses in relation to other SLE severe manifestations, which could imply a more aggressive form of SLE in patients with serositis.PMID:34794346 | DOI:10.1177/09612033211049305 (Source: Lupus)
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Laura Gimeno-Torres Irene Carri ón-Barberà Xavier Dur án Eduardo Villegas Jordi Monfort Tarek Carlos Salman-Monte Source Type: research

Early onset left ventricular remodeling in juvenile systemic lupus erythematosus; Insight from 3-dimensional speckle tracking echocardiography
Lupus. 2021 Nov 18:9612033211051302. doi: 10.1177/09612033211051302. Online ahead of print.ABSTRACTBACKGROUND: Early diagnosis and treatment of myocardial affection in patients with systemic lupus erythematosus (SLE) are crucial.OBJECTIVES: To evaluate the ventricular systolic function in juvenile-onset systemic lupus erythematosus (j-SLE) patients by 3-D speckle tracking echocardiography (3D-STE) and to determine the predictors of left ventricular (LV) dysfunction if present.METHODS: Twenty-six SLE patients without heart failure and 21 healthy controls were studied by standard echocardiogram and 3D-STE. Conventional param...
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Hala M Agha Mahmoud A Othman Sonia El-Saiedi Fatma El Zahrae Hassan Heba Taher Amal El-Sisi Rodina Sobhy Antoine A El Massih Source Type: research

Validity and reliability of patient reported outcomes measurement information system computerized adaptive tests in systemic lupus erythematous
CONCLUSIONS: These results provide evidence on the reliability and validity of PROMIS CAT in SLE in a Canadian cohort.PMID:34797991 | DOI:10.1177/09612033211051275 (Source: Lupus)
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Mitra Moazzami Patricia Katz Dennisse Bonilla Lisa Engel Jiandong Su Pooneh Akhavan Nicole Anderson Oshrat E Tayer-Shifman Dorcas Beaton Zahi Touma Source Type: research

Prevalence and risk factors for serositis in patients with systemic lupus erythematosus: A case-control study
CONCLUSION: The overall prevalence of serositis was 9.42%, being significantly higher in men (30%). Therefore, male gender constitutes a risk factor for serositis, and almost one third of men will develop this manifestation, so greater awareness is required in SLE men. CrithidiaDNA+ was also identified as a risk factor, and it should be determined in all SLE patients. Cases significantly received more corticosteroid pulses and higher maximum doses in relation to other SLE severe manifestations, which could imply a more aggressive form of SLE in patients with serositis.PMID:34794346 | DOI:10.1177/09612033211049305 (Source: Lupus)
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Laura Gimeno-Torres Irene Carri ón-Barberà Xavier Dur án Eduardo Villegas Jordi Monfort Tarek Carlos Salman-Monte Source Type: research

Early onset left ventricular remodeling in juvenile systemic lupus erythematosus; Insight from 3-dimensional speckle tracking echocardiography
Lupus. 2021 Nov 18:9612033211051302. doi: 10.1177/09612033211051302. Online ahead of print.ABSTRACTBACKGROUND: Early diagnosis and treatment of myocardial affection in patients with systemic lupus erythematosus (SLE) are crucial.OBJECTIVES: To evaluate the ventricular systolic function in juvenile-onset systemic lupus erythematosus (j-SLE) patients by 3-D speckle tracking echocardiography (3D-STE) and to determine the predictors of left ventricular (LV) dysfunction if present.METHODS: Twenty-six SLE patients without heart failure and 21 healthy controls were studied by standard echocardiogram and 3D-STE. Conventional param...
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Hala M Agha Mahmoud A Othman Sonia El-Saiedi Fatma El Zahrae Hassan Heba Taher Amal El-Sisi Rodina Sobhy Antoine A El Massih Source Type: research

Validity and reliability of patient reported outcomes measurement information system computerized adaptive tests in systemic lupus erythematous
CONCLUSIONS: These results provide evidence on the reliability and validity of PROMIS CAT in SLE in a Canadian cohort.PMID:34797991 | DOI:10.1177/09612033211051275 (Source: Lupus)
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Mitra Moazzami Patricia Katz Dennisse Bonilla Lisa Engel Jiandong Su Pooneh Akhavan Nicole Anderson Oshrat E Tayer-Shifman Dorcas Beaton Zahi Touma Source Type: research

Prevalence and risk factors for serositis in patients with systemic lupus erythematosus: A case-control study
CONCLUSION: The overall prevalence of serositis was 9.42%, being significantly higher in men (30%). Therefore, male gender constitutes a risk factor for serositis, and almost one third of men will develop this manifestation, so greater awareness is required in SLE men. CrithidiaDNA+ was also identified as a risk factor, and it should be determined in all SLE patients. Cases significantly received more corticosteroid pulses and higher maximum doses in relation to other SLE severe manifestations, which could imply a more aggressive form of SLE in patients with serositis.PMID:34794346 | DOI:10.1177/09612033211049305 (Source: Lupus)
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Laura Gimeno-Torres Irene Carri ón-Barberà Xavier Dur án Eduardo Villegas Jordi Monfort Tarek Carlos Salman-Monte Source Type: research

Early onset left ventricular remodeling in juvenile systemic lupus erythematosus; Insight from 3-dimensional speckle tracking echocardiography
Lupus. 2021 Nov 18:9612033211051302. doi: 10.1177/09612033211051302. Online ahead of print.ABSTRACTBACKGROUND: Early diagnosis and treatment of myocardial affection in patients with systemic lupus erythematosus (SLE) are crucial.OBJECTIVES: To evaluate the ventricular systolic function in juvenile-onset systemic lupus erythematosus (j-SLE) patients by 3-D speckle tracking echocardiography (3D-STE) and to determine the predictors of left ventricular (LV) dysfunction if present.METHODS: Twenty-six SLE patients without heart failure and 21 healthy controls were studied by standard echocardiogram and 3D-STE. Conventional param...
Source: Lupus - November 19, 2021 Category: Rheumatology Authors: Hala M Agha Mahmoud A Othman Sonia El-Saiedi Fatma El Zahrae Hassan Heba Taher Amal El-Sisi Rodina Sobhy Antoine A El Massih Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients - Analysis of the German LuLa study
CONCLUSION: In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.PMID:34739350 | DOI:10.1177/09612033211045063 (Source: Lupus)
Source: Lupus - November 5, 2021 Category: Rheumatology Authors: Anna Kernder Christina D üsing Jutta Richter Ralph Brinks Rebecca Fischer-Betz Borgi Winkler-Rohlfing Martin Aringer Matthias Schneider Gamal Chehab Source Type: research

Patient-reported outcome measures in systemic lupus erythematosus by a web-based application: A randomized, crossover, agreement study
CONCLUSION: For the first time ever, equivalence and comparability between two electronic device types for various PROMs were demonstrated among patients with SLE. Implementation of the device is expected to improve the management of SLE.PMID:34719299 | DOI:10.1177/09612033211051641 (Source: Lupus)
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Line Uhrenholt Simone H østgaard Julie F Pedersen Robin Christensen Lene Dreyer Henrik C B Leffers Peter C Taylor Vibeke Strand S øren Jacobsen Anne Voss Jon W Gregersen Salome Kristensen Source Type: research

Association of the premature immunosenescence with the presence and severity of anemia among patients with systemic lupus erythematosus
This study aimed to observe the correlation between immunosenescence with anemia in SLE.METHODS: This research was a cross-sectional study with the subject was 60 women with SLE aged 16-45 years old. Subjects were recorded for the demographic and clinical data, complete blood counts, iron status (iron serum, total iron-binding capacity, and transferrin saturation), ferritin, inflammatory markers (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]), and anti-dsDNA levels. Immunosenescence was observed by measuring the senescent T cells from peripheral blood mononuclear cells (PBMC) by flow cytometry, counted ...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kusworini Handono Cesarius Singgih Wahono Mirza Zaka Pratama Handono Kalim Source Type: research

Low disease activity state in juvenile-onset systemic lupus erythematosus
Lupus. 2021 Nov 1:9612033211054399. doi: 10.1177/09612033211054399. Online ahead of print.ABSTRACTOBJECTIVES: To determine the rate of achieving The Lupus Low Disease Activity State (LLDAS) in children with systemic lupus erythematosus (SLE) for tracing pertinent treatment modalities.METHODS: A total of 122 juvenile-onset SLE (jSLE) patients from six pediatric rheumatology centers in Turkey were enrolled in the study. LLDAS-50 was defined as encountering LLDAS for at least 50% of the observation time. According to the achievement of LLDAS-50, clinical features, immunological profiles, and treatments of patients with jSLE h...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kubra Ozturk Sen ğul Caglayan Ayse Tanatar Esra Baglan Gulcin Yener Otar Gulsah Kavrul Kayaalp Serife Gul Karadag Ferhat Demir Hafize Emine Sonmez Semanur Ozdel Mustafa Cakan Nuray Aktay Ayaz Betul Sozeri PeRA-Research Group Source Type: research

Patient-reported outcome measures in systemic lupus erythematosus by a web-based application: A randomized, crossover, agreement study
CONCLUSION: For the first time ever, equivalence and comparability between two electronic device types for various PROMs were demonstrated among patients with SLE. Implementation of the device is expected to improve the management of SLE.PMID:34719299 | DOI:10.1177/09612033211051641 (Source: Lupus)
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Line Uhrenholt Simone H østgaard Julie F Pedersen Robin Christensen Lene Dreyer Henrik C B Leffers Peter C Taylor Vibeke Strand S øren Jacobsen Anne Voss Jon W Gregersen Salome Kristensen Source Type: research

Association of the premature immunosenescence with the presence and severity of anemia among patients with systemic lupus erythematosus
This study aimed to observe the correlation between immunosenescence with anemia in SLE.METHODS: This research was a cross-sectional study with the subject was 60 women with SLE aged 16-45 years old. Subjects were recorded for the demographic and clinical data, complete blood counts, iron status (iron serum, total iron-binding capacity, and transferrin saturation), ferritin, inflammatory markers (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]), and anti-dsDNA levels. Immunosenescence was observed by measuring the senescent T cells from peripheral blood mononuclear cells (PBMC) by flow cytometry, counted ...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kusworini Handono Cesarius Singgih Wahono Mirza Zaka Pratama Handono Kalim Source Type: research

Low disease activity state in juvenile-onset systemic lupus erythematosus
Lupus. 2021 Nov 1:9612033211054399. doi: 10.1177/09612033211054399. Online ahead of print.ABSTRACTOBJECTIVES: To determine the rate of achieving The Lupus Low Disease Activity State (LLDAS) in children with systemic lupus erythematosus (SLE) for tracing pertinent treatment modalities.METHODS: A total of 122 juvenile-onset SLE (jSLE) patients from six pediatric rheumatology centers in Turkey were enrolled in the study. LLDAS-50 was defined as encountering LLDAS for at least 50% of the observation time. According to the achievement of LLDAS-50, clinical features, immunological profiles, and treatments of patients with jSLE h...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kubra Ozturk Sen ğul Caglayan Ayse Tanatar Esra Baglan Gulcin Yener Otar Gulsah Kavrul Kayaalp Serife Gul Karadag Ferhat Demir Hafize Emine Sonmez Semanur Ozdel Mustafa Cakan Nuray Aktay Ayaz Betul Sozeri PeRA-Research Group Source Type: research

Patient-reported outcome measures in systemic lupus erythematosus by a web-based application: A randomized, crossover, agreement study
CONCLUSION: For the first time ever, equivalence and comparability between two electronic device types for various PROMs were demonstrated among patients with SLE. Implementation of the device is expected to improve the management of SLE.PMID:34719299 | DOI:10.1177/09612033211051641 (Source: Lupus)
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Line Uhrenholt Simone H østgaard Julie F Pedersen Robin Christensen Lene Dreyer Henrik C B Leffers Peter C Taylor Vibeke Strand S øren Jacobsen Anne Voss Jon W Gregersen Salome Kristensen Source Type: research

Association of the premature immunosenescence with the presence and severity of anemia among patients with systemic lupus erythematosus
This study aimed to observe the correlation between immunosenescence with anemia in SLE.METHODS: This research was a cross-sectional study with the subject was 60 women with SLE aged 16-45 years old. Subjects were recorded for the demographic and clinical data, complete blood counts, iron status (iron serum, total iron-binding capacity, and transferrin saturation), ferritin, inflammatory markers (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]), and anti-dsDNA levels. Immunosenescence was observed by measuring the senescent T cells from peripheral blood mononuclear cells (PBMC) by flow cytometry, counted ...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kusworini Handono Cesarius Singgih Wahono Mirza Zaka Pratama Handono Kalim Source Type: research

Low disease activity state in juvenile-onset systemic lupus erythematosus
Lupus. 2021 Nov 1:9612033211054399. doi: 10.1177/09612033211054399. Online ahead of print.ABSTRACTOBJECTIVES: To determine the rate of achieving The Lupus Low Disease Activity State (LLDAS) in children with systemic lupus erythematosus (SLE) for tracing pertinent treatment modalities.METHODS: A total of 122 juvenile-onset SLE (jSLE) patients from six pediatric rheumatology centers in Turkey were enrolled in the study. LLDAS-50 was defined as encountering LLDAS for at least 50% of the observation time. According to the achievement of LLDAS-50, clinical features, immunological profiles, and treatments of patients with jSLE h...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kubra Ozturk Sen ğul Caglayan Ayse Tanatar Esra Baglan Gulcin Yener Otar Gulsah Kavrul Kayaalp Serife Gul Karadag Ferhat Demir Hafize Emine Sonmez Semanur Ozdel Mustafa Cakan Nuray Aktay Ayaz Betul Sozeri PeRA-Research Group Source Type: research

Patient-reported outcome measures in systemic lupus erythematosus by a web-based application: A randomized, crossover, agreement study
CONCLUSION: For the first time ever, equivalence and comparability between two electronic device types for various PROMs were demonstrated among patients with SLE. Implementation of the device is expected to improve the management of SLE.PMID:34719299 | DOI:10.1177/09612033211051641 (Source: Lupus)
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Line Uhrenholt Simone H østgaard Julie F Pedersen Robin Christensen Lene Dreyer Henrik C B Leffers Peter C Taylor Vibeke Strand S øren Jacobsen Anne Voss Jon W Gregersen Salome Kristensen Source Type: research

Association of the premature immunosenescence with the presence and severity of anemia among patients with systemic lupus erythematosus
This study aimed to observe the correlation between immunosenescence with anemia in SLE.METHODS: This research was a cross-sectional study with the subject was 60 women with SLE aged 16-45 years old. Subjects were recorded for the demographic and clinical data, complete blood counts, iron status (iron serum, total iron-binding capacity, and transferrin saturation), ferritin, inflammatory markers (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]), and anti-dsDNA levels. Immunosenescence was observed by measuring the senescent T cells from peripheral blood mononuclear cells (PBMC) by flow cytometry, counted ...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kusworini Handono Cesarius Singgih Wahono Mirza Zaka Pratama Handono Kalim Source Type: research

Low disease activity state in juvenile-onset systemic lupus erythematosus
Lupus. 2021 Nov 1:9612033211054399. doi: 10.1177/09612033211054399. Online ahead of print.ABSTRACTOBJECTIVES: To determine the rate of achieving The Lupus Low Disease Activity State (LLDAS) in children with systemic lupus erythematosus (SLE) for tracing pertinent treatment modalities.METHODS: A total of 122 juvenile-onset SLE (jSLE) patients from six pediatric rheumatology centers in Turkey were enrolled in the study. LLDAS-50 was defined as encountering LLDAS for at least 50% of the observation time. According to the achievement of LLDAS-50, clinical features, immunological profiles, and treatments of patients with jSLE h...
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Kubra Ozturk Sen ğul Caglayan Ayse Tanatar Esra Baglan Gulcin Yener Otar Gulsah Kavrul Kayaalp Serife Gul Karadag Ferhat Demir Hafize Emine Sonmez Semanur Ozdel Mustafa Cakan Nuray Aktay Ayaz Betul Sozeri PeRA-Research Group Source Type: research

Patient-reported outcome measures in systemic lupus erythematosus by a web-based application: A randomized, crossover, agreement study
CONCLUSION: For the first time ever, equivalence and comparability between two electronic device types for various PROMs were demonstrated among patients with SLE. Implementation of the device is expected to improve the management of SLE.PMID:34719299 | DOI:10.1177/09612033211051641 (Source: Lupus)
Source: Lupus - November 1, 2021 Category: Rheumatology Authors: Line Uhrenholt Simone H østgaard Julie F Pedersen Robin Christensen Lene Dreyer Henrik C B Leffers Peter C Taylor Vibeke Strand S øren Jacobsen Anne Voss Jon W Gregersen Salome Kristensen Source Type: research

Dissociation in SLE: A part of lupus fog?
DISCUSSION: In most patients with SLE and neuropsychiatric symptoms, dissociative symptoms are within normal range, regardless of underlying etiology. Dissociative fog is present, but uncommon. Lupus fog is most likely not associated with dissociation.PMID:34715747 | DOI:10.1177/09612033211050347 (Source: Lupus)
Source: Lupus - October 30, 2021 Category: Rheumatology Authors: Rory C Monahan Anne Me Blonk Esther Baptist Huub Am Middelkoop Margreet Kloppenburg Tom Wj Huizinga Nic J van der Wee Gerda M Steup-Beekman Source Type: research

Association between systemic lupus erythematosus and risk of cervical atypia: A meta-analysis
Lupus. 2021 Oct 29:9612033211048129. doi: 10.1177/09612033211048129. Online ahead of print.ABSTRACTBACKGROUND: Previous studies showed conflicting results regarding the association between systemic lupus erythematosus (SLE) and risk of cervical atypia. Therefore, the present study aimed to make a meta-analysis to summarize results of studies regarding association between SLE and risk of cervical atypia.METHODS: We searched for articles published before March 2021 in in the following databases: PubMed, EMBASE, Web of Science, Medline and Google Scholar. Odds ratios (ORs) and relative risks (RRs) with their 95% confidence in...
Source: Lupus - October 30, 2021 Category: Rheumatology Authors: Yanya Chen Xuewei Wu Lu Liu Source Type: research

Dissociation in SLE: A part of lupus fog?
DISCUSSION: In most patients with SLE and neuropsychiatric symptoms, dissociative symptoms are within normal range, regardless of underlying etiology. Dissociative fog is present, but uncommon. Lupus fog is most likely not associated with dissociation.PMID:34715747 | DOI:10.1177/09612033211050347 (Source: Lupus)
Source: Lupus - October 30, 2021 Category: Rheumatology Authors: Rory C Monahan Anne Me Blonk Esther Baptist Huub Am Middelkoop Margreet Kloppenburg Tom Wj Huizinga Nic J van der Wee Gerda M Steup-Beekman Source Type: research

Association between systemic lupus erythematosus and risk of cervical atypia: A meta-analysis
Lupus. 2021 Oct 29:9612033211048129. doi: 10.1177/09612033211048129. Online ahead of print.ABSTRACTBACKGROUND: Previous studies showed conflicting results regarding the association between systemic lupus erythematosus (SLE) and risk of cervical atypia. Therefore, the present study aimed to make a meta-analysis to summarize results of studies regarding association between SLE and risk of cervical atypia.METHODS: We searched for articles published before March 2021 in in the following databases: PubMed, EMBASE, Web of Science, Medline and Google Scholar. Odds ratios (ORs) and relative risks (RRs) with their 95% confidence in...
Source: Lupus - October 30, 2021 Category: Rheumatology Authors: Yanya Chen Xuewei Wu Lu Liu Source Type: research

Summary of the 12th Meeting of the European Forum on antiphospholipid antibodies ONLINE
This report summarizes major studies and new research projects presented during the online forum meeting.PMID:34696636 | DOI:10.1177/09612033211055010 (Source: Lupus)
Source: Lupus - October 26, 2021 Category: Rheumatology Authors: Aleksandra Djokovic Ljudmila Stojanovich Source Type: research

Summary of the 12th Meeting of the European Forum on antiphospholipid antibodies ONLINE
This report summarizes major studies and new research projects presented during the online forum meeting.PMID:34696636 | DOI:10.1177/09612033211055010 (Source: Lupus)
Source: Lupus - October 26, 2021 Category: Rheumatology Authors: Aleksandra Djokovic Ljudmila Stojanovich Source Type: research

Summary of the 12th Meeting of the European Forum on antiphospholipid antibodies ONLINE
This report summarizes major studies and new research projects presented during the online forum meeting.PMID:34696636 | DOI:10.1177/09612033211055010 (Source: Lupus)
Source: Lupus - October 26, 2021 Category: Rheumatology Authors: Aleksandra Djokovic Ljudmila Stojanovich Source Type: research

Summary of the 12th Meeting of the European Forum on antiphospholipid antibodies ONLINE
This report summarizes major studies and new research projects presented during the online forum meeting.PMID:34696636 | DOI:10.1177/09612033211055010 (Source: Lupus)
Source: Lupus - October 26, 2021 Category: Rheumatology Authors: Aleksandra Djokovic Ljudmila Stojanovich Source Type: research

The new 2019-EULAR/ACR classification criteria specific domains at diagnosis can predict damage accrual in 670 childhood-onset systemic lupus erythematosus patients
Lupus. 2021 Oct 25:9612033211054397. doi: 10.1177/09612033211054397. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate if the 2019-European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) criteria at diagnosis of childhood-onset systemic lupus erythematosus (cSLE) are associated with higher rates of early damage scored by Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI).METHODS: This retrospective multicenter study included 670 cSLE patients with ≤5 years of disease duration. All patients fulfilled both 2019-EULAR/ACR and 1997-AC...
Source: Lupus - October 25, 2021 Category: Rheumatology Authors: Ana C Pitta Clovis A Silva Carlos E Insfr án Sandra G Pasoto Vitor C Trindade Glaucia V Novak Ana P Sakamoto Maria T Terreri Rosa Mr Pereira Claudia S Magalh ães Adriana R Fonseca Aline G Islab ão Ana Pl Assad Izabel M Buscatti Adriana M Elias Daniela Source Type: research