Bronchiolitis obliterans organizing pneumonia as the pulmonary manifestation of lupus: A review of three cases.
CONCLUSION: BOOP is a rare pulmonary manifestation in lupus. It can be diagnosed early with more precision using computerised tomography of lung without waiting for biopsy report. This will result in a better prognosis by rapid initiation of corticosteroid and immunosuppressive treatment. PMID: 33103988 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 26, 2020 Category: Rheumatology Authors: Baisya R, Devarasetti PK, Uppin SG, Narayanan R, Rajasekhar L, Sreejitha KS Tags: Lupus Source Type: research

Reticular erythematous mucinosis: Literature review and case report of a 24-year-old patient with systemic erythematosus lupus.
We report a case of REM, including the clinical and histopathological findings. Also, a systematic review of 94 English-language reported cases is provided. The described criteria for clinical and histopathological diagnosis are highlighted in order to REM can be confidently diagnosed. PMID: 33096958 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 23, 2020 Category: Rheumatology Authors: Ocanha-Xavier JP, Cola-Senra CO, Xavier-Junior JCC Tags: Lupus Source Type: research

Multimorbidity among incident Finnish systemic lupus erythematosus patients during 2000-2017.
The objective of the study was to examine the risk of other morbidities among patients with systemic lupus erythematosus (SLE). A total of 1006 adult new-onset SLE patients were identified during 1.1.2000- 31.12.2014 from the register of Social Insurance Institution. For each case three general population controls matched according to age, sex and place of residence at the index day were sampled from the population register. Both groups were followed up from the index date until the end of 2017 or until death. The national register on specialized care was explored to gather broadly their 12 organ-specific morbidities, whic...
Source: Lupus - October 22, 2020 Category: Rheumatology Authors: Kariniemi S, Rantalaiho V, Virta LJ, Puolakka K, Sokka-Isler T, Elfving P Tags: Lupus Source Type: research

Portal vein thrombosis, livedo reticularis, polymicrobial sepsis and high antiphospholipid antibody titers in a newborn: A clinicopathological conference of antiphospholipid-associated neonatal syndrome.
We describe a 5-week-old infant who developed fever, portal vein thrombosis and livedo reticularis like skin rash. Evaluation for thrombosis revealed high titers of antiphospholipid (aPL) antibodies (dual positive) in the child without any evidence of aPL antibodies in the mother, suggesting a de novo production in the child. Autopsy findings revealed umbilical vein sepsis with thrombosis of portal vein secondary to gram positive cocci which led to multiple liver and lung abscesses. Additionally, the baby had disseminated Cytomegalovirus (CMV) disease (acquired postnatally) involving walls of umbilical and portal vein, liv...
Source: Lupus - October 22, 2020 Category: Rheumatology Authors: Chaudhary H, Jindal P, Pandiarajan V, Kumar J, Sudhakar M, Ezhumalai G, Nada R, Gupta K Tags: Lupus Source Type: research

Characterization of autoantibodies and cytokines related to cutaneous lupus erythematosus.
CONCLUSION: Serum anti-RPLP0, anti-galectin3 antibodies, IFN-α, IFN-λ1 and IL-17A/F are associated with the occurrence of lupus skin lesions regardless of the systemic complications, whereas the profiles of these inflammatory mediators vary with the subtypes of lupus skin lesions. PMID: 33086919 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 22, 2020 Category: Rheumatology Authors: Hu FQ, Zhang YP, Yin J, Tang ZQ, Han YF, Shi ZR, Tan GZ, Wang L Tags: Lupus Source Type: research

Mean platelet volume in children with systemic lupus erythematosus.
CONCLUSION: MPV increased in active phase of patients with SLE and can be an easy, rapid, inexpensive and simple method to assess disease activity in children with SLE. PMID: 33092466 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 22, 2020 Category: Rheumatology Authors: A Talat M, An Allah M, Khalifa NA, Sakr MMH, Mohammed EM, K Amin E Tags: Lupus Source Type: research

Improving sensitivity of the connective tissue disease screening questionnaire: A comparative study of various scoring methods.
CONCLUSION: The adapted CSQ with the classification criteria-based scoring achieved relatively high sensitivities in detecting autoimmune rheumatic diseases, suggesting this could be employed as the first step in population screening. PMID: 33092467 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 22, 2020 Category: Rheumatology Authors: Xiang L, Low AHL, Leung YY, Fong W, Gandhi M, Xin X, Uy EJ, Sparks JA, Karlson EW, Thumboo J Tags: Lupus Source Type: research

Venous thrombosis in a systemic lupus erythematosus patient with antiphospholipid antibodies coinciding with mild Covid-19.
is CM PMID: 33092468 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 22, 2020 Category: Rheumatology Authors: Elena AM, Silvia SD, Francisco RJ, Rubén CH, Luis CM Tags: Lupus Source Type: research

SIGLEC1 (CD169) is a sensitive biomarker for the deterioration of the clinical course in childhood systemic lupus erythematosus.
Abstract BACKGROUND: To analyse the validity of membrane-bound SIGLEC1 (CD169) as a sensitive biomarker for monitoring disease activity in pediatric systemic lupus erythematosus (SLE). METHODS: 27 children and adolescents with SLE were followed for a mean of 13.5 months. During consecutive routine visits SLEDAI-2k, C3, C4 and ds-DNA values were determined. Additionally, expression of SIGLEC1 on monocytes was determined by flow cytometry. The amount of PE-labelled CD169 mAb bound per monocyte was analyzed using QuantiBRITE™ PE tubes. Associations between biomarkers and the clinical course were inv...
Source: Lupus - October 20, 2020 Category: Rheumatology Authors: Stuckrad SLV, Klotsche J, Biesen R, Lieber M, Thumfart J, Meisel C, Unterwalder N, Kallinich T Tags: Lupus Source Type: research

What is the value of repeat kidney biopsies in patients with lupus nephritis?
alindo M, Praga M Abstract INTRODUCTION: Recent studies with protocol biopsies have shown a mismatch between clinical and histological remission in lupus nephritis (LN). We aimed to evaluate histological changes in repeat kidney biopsies by clinical indication in patients with LN. METHODS: We analyzed 107 patients with LN in which a kidney biopsy was performed between 2008 and 2018. Of those, we included 26 (24.2%) who had ≥2 kidney biopsies. Classification was done according to the International Society of Nephrology/Renal Pathology Society. RESULTS: Mean time between biopsies was 71.5 ±...
Source: Lupus - October 20, 2020 Category: Rheumatology Authors: Morales E, Trujillo H, Bada T, Alonso M, Gutiérrez E, Rodríguez E, Gutiérrez E, Galindo M, Praga M Tags: Lupus Source Type: research

Associations of site-specific CD4+-T-cell hypomethylation within CD40-ligand promotor and enhancer regions with disease activity of women with systemic lupus erythematosus.
CONCLUSION: Site-specific hypomethylation of the CD40L promotor in CD4+-T-cells show associations with disease activity in female SLE patients. PMID: 33081589 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 20, 2020 Category: Rheumatology Authors: Vordenbäumen S, Rosenbaum A, Gebhard C, Raithel J, Sokolowski A, Düsing C, Chehab G, Richter JG, Brinks R, Rehli M, Schneider M Tags: Lupus Source Type: research

Prevention of recurrent miscarriage in women with antiphospholipid syndrome: A systematic review and network meta-analysis.
CONCLUSIONS: Our findings support the use of low-dose aspirin plus heparin as the first-line treatment for prevention of RM in women with APS, and support the efficacy of hydroxychloroquine, IVIG, and prednisone when added to current treatment regimens. More large-scale, high-quality RCTs are needed to confirm these findings, and new pharmacological options should be further evaluated. PMID: 33081590 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 20, 2020 Category: Rheumatology Authors: Yang Z, Shen X, Zhou C, Wang M, Liu Y, Zhou L Tags: Lupus Source Type: research

Next stop in the treatment of refractory systemic lupus erythematosus: B-cell targeted combined therapy.
Conclusion: Further randomized clinical trials are needed to examine this drug sequencing protocol in SLE patients. PMID: 33081591 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 20, 2020 Category: Rheumatology Authors: Bela MM, Espinosa G, Cervera R Tags: Lupus Source Type: research

Pediatric catastrophic antiphospholipid syndrome patient evolving to systemic lupus erythematosus.
CONCLUSION: This article reports a very unusual presentation which is rarely reported and clinicians should be alert to the possibility that CAPS may be the presenting event for SLE patients, condition known in adults and should also be remembered in pediatric scenario. PMID: 33081592 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 20, 2020 Category: Rheumatology Authors: Carvalho JF, Silva FF, Shoenfeld Y Tags: Lupus Source Type: research

Mortality in patients with systemic lupus erythematosus and neuropsychiatric involvement: A retrospective analysis from a tertiary referral center in the Netherlands.
CONCLUSION: Mortality was increased in both major NPSLE and minor/non-NPSLE patients in comparison with the general population. There was no difference in mortality between major NPSLE and minor/non-NPSLE patients. PMID: 33079617 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 20, 2020 Category: Rheumatology Authors: Monahan RC, Fronczek R, Eikenboom J, Middelkoop HA, Beaart-van de Voorde LJ, Terwindt GM, van der Wee NJ, Rosendaal FR, Huizinga TW, Kloppenburg M, Steup-Beekman GM Tags: Lupus Source Type: research

Clinical management of Lupus patients during the COVID-19 pandemic.
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV-2), the virus causing Coronavirus disease 2019 (COVID-19), has had a huge impact on health services with a high mortality associated with complications including pneumonia and acute respiratory distress syndrome. Historical evidence suggests that Lupus patients have a higher incidence of several viral infections. This is likely due to a combination of immune dysfunction, immunosuppressive therapy and excess co-morbidities. In this context there has been concern that Lupus patients may be at a higher risk of developing COVID-19 and suffering a severe ...
Source: Lupus - October 15, 2020 Category: Rheumatology Authors: Mason A, Rose E, Edwards CJ Tags: Lupus Source Type: research

Early damage as measured by SLICC/ACR damage index is a predictor of hospitalization in systemic lupus erythematosus (SLE).
Abstract BACKGROUND: Hospital admissions and re-admissions in lupus patients are common occurrences that can lead to poor prognosis. OBJECTIVES: We evaluated the leading causes of all-cause hospitalizations and their predictive factors in the Malaysian multi-ethnic SLE patients. METHODS: This is a retrospective study involving 300 SLE patients. Demographic data and details of hospitalizations from the year 1988 until 2019 were reviewed. Baseline and latest disease activity (SLEDAI-2 K) and SLICC/ACR damage index (SDI) scores were evaluated. To be eligible for this study, their SLE diagnosis and di...
Source: Lupus - October 12, 2020 Category: Rheumatology Authors: Raman L, Yahya F, Ng CM, Sockalingam S, Ramasamy K, Ratnam R, Raja J Tags: Lupus Source Type: research

A decade follow-up: On the prevalence, distribution and clinical correlates of myocardial fibrosis, as detected by cardiac magnetic resonance, in systemic lupus erythematosus.
PMID: 33040648 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 12, 2020 Category: Rheumatology Authors: Verma R, Balaraju V, Seneviratne M, Garsia R, Adelstein S, Puranik R, Dennis M Tags: Lupus Source Type: research

Pathological manifestation of autoimmune myocarditis is detected prior to glomerulonephritis in a murine model of lupus nephritis.
CONCLUSIONS: Histopathology, functional abnormalities, and enhanced cMRI signals indicative of myocarditis are detected in NZM2410 mice without glomerulonephritis, which supports the primary pathological role of autoimmune-mediated, cardiac-targeted inflammation in lupus. PMID: 33045900 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 12, 2020 Category: Rheumatology Authors: Young NA, Jablonski K, Schwarz E, Okafor I, Hampton J, Valiente GR, Henry C, Harb P, Barger J, Bratasz A, Kalyanasundaram A, Ardoin SP, Jarjour WN Tags: Lupus Source Type: research

A comparison and review of three sets of classification criteria for systemic lupus erythematosus for distinguishing systemic lupus erythematosus from pure mucocutaneous manifestations in the lupus disease spectrum.
Y, Ren X, Xue H, Wei Z, Chen J, Li F, Ling G, Luo H, Zhao H, Yang S, Cui Y, Lin Y, Yao X, Sun L, Guo Q, Fang H, Zeng K, Deng D, Zhang J, Li Y, Pu X, Liao X, Dang X, Huang D, Liang Y, Sun Q, Xie H, Zeng L, Huang C, Diao Q, Tao J, Yu J, Li Z, Xu H, Li H, Lai W, Liu X, Wu J, Li T, Lei T, Sun Q, Li Y, Zhang G, Huang X, Lu Q Abstract Although the original purpose of the systemic lupus erythematosus (SLE) classification criteria was to distinguish SLE from other mimic diseases, and to facilitate sample selection in scientific research, they have become widely used as diagnostic criteria in clinical situations. It is not...
Source: Lupus - October 7, 2020 Category: Rheumatology Authors: Jin H, Huang T, Wu R, Zhao M, Wu H, Long H, Yin H, Liao J, Luo S, Liu Y, Zhang Q, Zhang P, Tan Y, Luo S, Huang X, Deng Y, Liao W, Duan L, Chen J, Zhou Y, Yin J, Qiu H, Yuan J, Wang Z, Li M, Wu X, Chen L, Cai L, Huang C, Li Q, Tang B, Yu B, Li X, Gao X, Hu Tags: Lupus Source Type: research

Validation of the adjusted global antiphospholipid syndrome score in systemic lupus erythematosus patients in Argentina.
Abstract INTRODUCTION: Assessment of risk both for pregnancy morbidity and thrombosis in the presence of anti-phospholipid antibodies (aPL) is still a challenge in Systemic Lupus Erythematosus (SLE) patients. The Global Antiphospholipid Syndrome Score (GAPSS) takes into account the aPL profile (criteria and non-criteria aPL), the conventional cardiovascular risk factors and the autoimmune antibody profile. An adjusted model of the score (aGAPSS) excluding anti-phosphatidylserine/Prothrombin (aPS/PT), suggests that the score is able to stratify patients for their rate of events making it widely applicable in daily ...
Source: Lupus - October 7, 2020 Category: Rheumatology Authors: Garcia L, Velloso MS, Martire MV, Savy F, Arizpe F, Garcia N, Testi A, Pena C, Costi AC, Isnardi C, Capelusnik D, Mazza S, Curi YS, Collado V, Rodriguez MF, Scarafia S, Pisoni C, de la Torre M, Seewald A, Riva ME, Garcia M Tags: Lupus Source Type: research

Impact of the COVID-19 pandemic on patients with systemic lupus erythematosus: Observations from an Indian inception cohort.
CONCLUSION: The current COVID-19 pandemic has made a huge impact on our SLE patients. Patients faced difficulty in the availability of medicines, missed the doses of medicines, had financial constraints, and spent more money on health during the pandemic. PMID: 33019877 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 6, 2020 Category: Rheumatology Authors: Rathi M, Singh P, Bi HP, Shivanna A, Kavadichanda C, Tripathy SR, Parthasarathy J, Tota S, Maurya S, Vijayalekshmi V, Bhavani D, Jain A, Gupta R, Danda D, Rajasekhar L, Negi VS, Shobha V, Das B, Aggarwal A Tags: Lupus Source Type: research

Proton magnetic resonance spectroscopy (1H-MRS) in rheumatic autoimmune diseases: A systematic review.
CONCLUSION: The presence of neurometabolite abnormalities in patients without ouvert CNS manifestations, suggests that systemic inflammation, atherosclerosis or abnormal vascular reactivity may be associated with subclinical CNS manifestations. MRS may be a usefull non-invasive method for screening patients with risk for CNS manifestations. PMID: 33019878 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 6, 2020 Category: Rheumatology Authors: Frittoli RB, Pereira DR, Rittner L, Appenzeller S Tags: Lupus Source Type: research

The combined role of clinical, reflectance confocal microscopy and dermoscopy applied to chronic discoid cutaneous lupus and subacutus lupus erythematosus: A case series and literature review.
In this study, we reported dermoscopic and RCM features about 9 patients affected by subacute and chronic lupus erythematosus retrospectively analyzed. PMID: 33019879 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 6, 2020 Category: Rheumatology Authors: Mazzilli S, Vollono L, Diluvio L, Botti E, Costanza G, Campione E, Donati M, Prete MD, Orlandi A, Bianchi L, Gonzalez S Tags: Lupus Source Type: research

Cytomegalovirus-induced cutaneous ulcer mimicking vasculitis in a patient with systemic lupus erythematous: A case report and review of the literature.
In this report, a very rare clinical form of CMV infection manifesting as cutaneous necrotizing vasculitis on the lower extremity is described and the literature regarding this case is reviewed. PMID: 33012246 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 4, 2020 Category: Rheumatology Authors: Hajihashemi Z, Bidari-Zerehpoosh F, Zahedi K, Eslami B, Mozafari N Tags: Lupus Source Type: research

Cerebral artery dissection secondary to antiphospholipid syndrome: A report of two cases and a literature review.
CONCLUSIONS: The current report described two rare cases of ischemic stroke caused by CAD secondary to APS, along with a review of the literature; the patients displayed characteristic clinical manifestations, implying specific mechanisms for cerebral artery disorders secondary to APS. PMID: 33016197 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 3, 2020 Category: Rheumatology Authors: Iseki T, Yamashita Y, Ueno Y, Hira K, Miyamoto N, Yamashiro K, Tsunemi T, Teranishi K, Yatomi K, Nakajima S, Kijima C, Oishi H, Hattori N Tags: Lupus Source Type: research

Autoimmune thyroid diseases, autoimmune hepatitis, celiac disease and type 1 diabetes mellitus in pediatric systemic lupus erythematosus: Results from the CARRA Legacy Registry.
CONCLUSION: In cSLE, PA is associated with more hospitalizations and aggressive immunotherapy use. Although lupus disease activity improved over time, patients' QoL neither improved over time nor differed by having other autoimmune disease. Prospective, case-control, long-term follow-up studies on cSLE are needed to validate our results. MESH KEY INDEXING TERMS: Pediatric systemic lupus erythematosus; Autoimmune diseases; Outcome assessment. PMID: 33016198 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 3, 2020 Category: Rheumatology Authors: AlAhmed O, Sivaraman V, Moore-Clingenpeel M, Ardoin SP, Bout-Tabaku S, CARRA registry investigators Tags: Lupus Source Type: research

Altered oxidative stress markers in relation to T cells, NK cells & killer immunoglobulin receptors that are associated with disease activity in SLE patients.
Altered oxidative stress markers in relation to T cells, NK cells & killer immunoglobulin receptors that are associated with disease activity in SLE patients. Lupus. 2020 Sep 30;:961203320959441 Authors: Tandon A, Anupam K, Kaushal J, Gautam P, Sharma A, Bhatnagar A Abstract Systemic Lupus Erythematosus is an autoimmune disease with symptoms pervasive to all organ systems. It affects more females as compared to males (in the ratio 9:1). Oxidative stress plays a major role in the pathogenesis of SLE and other autoimmune diseases. In order to understand the relationship between cell specific oxidati...
Source: Lupus - September 29, 2020 Category: Rheumatology Authors: Tandon A, Anupam K, Kaushal J, Gautam P, Sharma A, Bhatnagar A Tags: Lupus Source Type: research

In-hospital mortality and its predictors in a cohort of SLE from Northern India.
CONCLUSION: Infections are the most common cause of in-hospital mortality in SLE and TB still accounts for 15% of deaths related to infection. Vasculitis, myositis, cardiovascular and gastrointestinal involvement emerged as novel predictors of mortality in our cohort. PMID: 32998621 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 29, 2020 Category: Rheumatology Authors: Pattanaik SS, Muhammed H, Chatterjee R, Naveen R, Lawrence A, Agarwal V, Misra DP, Gupta L, Misra R, Aggarwal A Tags: Lupus Source Type: research

Biologics targeting type I interferons in SLE: A meta-analysis and systematic review of randomised controlled trials.
Abstract OBJECTIVE: The feed-forward loop of type I interferons (IFNs) production and subsequent immunopathology of systemic lupus erythematosus (SLE) has been hypothesised to be disrupted with inhibition of IFNα or type I IFN receptor subunit 1 (IFNAR). This systematic review and meta-analysis present the treatment efficacy and safety profile of monoclonal antibodies inhibiting IFNα or IFNAR. METHODS: A search was done using Medline, Embase and ClinicalTrials.gov for biologics targeting IFNα or IFNAR in SLE up to 3 Jan 2020. For the meta-analysis, analyses of binary variables were pooled us...
Source: Lupus - September 21, 2020 Category: Rheumatology Authors: Koh JWH, Ng CH, Tay SH Tags: Lupus Source Type: research

Prevalence, involved domains, and predictor of cognitive dysfunction in systemic lupus erythematosus.
CONCLUSION: The prevalence of SLE-related CD was 67.9% in our study and SLE-related CD was not associated with disease activity. Serum anti-NMDAR antibody can be used as a predictor for SLE-related CD. PMID: 32938321 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 16, 2020 Category: Rheumatology Authors: Yue R, Gurung I, Long XX, Xian JY, Peng XB Tags: Lupus Source Type: research

Detection of putative autoantibodies in systemic lupus erythematous using a novel native-conformation protein microarray platform.
CONCLUSION: A high-throughput protein microarray platform allows detection and quantification of putative lupus-related autoantibodies which are of potential pathophysiological and prognostic significance in SLE patients. PMID: 32941107 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 16, 2020 Category: Rheumatology Authors: Mak A, Kow NY, Ismail NH, Anuar ND, Rutt NH, Cho J, Rosli NSBM, Dharmahidari B Tags: Lupus Source Type: research

'More extraordinary than mundane  … ' A phenomenological analysis of the experiences of individuals living with CLE and their taking care in the sun.
CONCLUSION: This study provides a nuanced insight into the lived experiences of individuals with CLE and their photoprotective practices. Taking care in the sun is not a simplistic process. Beyond the biomedical model of illness, the social impact that CLE has on individuals has a dominant influence on their photoprotective behaviours. Such insights could help healthcare professionals tailor photoprotective advice. PMID: 32941108 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 16, 2020 Category: Rheumatology Authors: McGarry B, O'Kane D, McCourt C, Gormley GJ Tags: Lupus Source Type: research

Juvenile lupus and serum vitamin D levels: A cross-sectional study.
This study was conducted on 100 patients with JSLE and 100 healthy children as controls. Disease duration and SLEDAI for disease activity were evaluated. CBC, anti-dsDNA, C3,C4,24hr urinary proteins, creatinine, estimated glomerular filtration rate(e-GFR),Ca,P,PTH, 25 (OH) D levels, and bone mineral density(BMD)Z score were measured. RESULTS: There were significant differences in mean 25(OH)D concentration between patients group (19.37 ± 9.72 ng/ml) and controls 35.90 ± 9.66 ng/ml(p 
Source: Lupus - September 12, 2020 Category: Rheumatology Authors: Tabra SAA, Abdelnabi HH, Darwish NFM, El-Barbary AM, AbdelGhafar MT, Abu-Zaid MH Tags: Lupus Source Type: research

Unilateral facial erythematous patch as the presenting sign of systemic lupus erythematosus.
Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can have many cutaneous manifestations including malar rash, discoid rash or oral ulcer. Isolated unilateral involvement of face is uncommon in SLE. It lacks typical clinical features of LE, and may impose a diagnostic challenge for clinicians. Herein we report a case of 62-year-old woman presenting with a 2-year history of erythematous patches on left cheek and eyelid. Initially, she was diagnosed as having recurrent blepharitis or cellulitis that did not respond to conventional treatment with ophthalmic medicaments. As time went by...
Source: Lupus - September 12, 2020 Category: Rheumatology Authors: Ha DL, Lee GW, Shin K, Kim HS, Ko HC, Kim BS, Kim MB Tags: Lupus Source Type: research

Cell-free DNA profiling in patients with lupus nephritis.
CONCLUSIONS: We showed that cfDNA profiling may help to distinguish SLE patients with renal involvement and severe disease course from patients with more favorable outcomes. We suggest cfDNA profile a promising SLE biomarker. PMID: 32924831 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 12, 2020 Category: Rheumatology Authors: Truszewska A, Wirkowska A, Gala K, Truszewski P, Krzemień-Ojak Ł, Perkowska-Ptasińska A, Mucha K, Pączek L, Foroncewicz B Tags: Lupus Source Type: research

Prevalence and incidence of systemic lupus erythematosus in Tucum án, Argentina.
CONCLUSION: The prevalence of SLE in the province of Tucumán was 34.9 cases/100.000 inhabitants. PMID: 32924832 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 12, 2020 Category: Rheumatology Authors: Gonzalez Lucero L, Barbaglia AL, Bellomio VI, Bertolaccini MC, Machado Escobar MA, Sueldo HR, Yacuzzi MS, Carrizo GA, Robles N, Rengel S, Cristofari A, Leal MO, Vasquez DL, Quinteros A, Seleme G, Molina MJ, Pera OL, Dip R, Olea AC, Torres AY, Espindola Ec Tags: Lupus Source Type: research

Severe pulmonary arterial hypertension and interstitial pneumonia related to systemic lupus erythematosus successfully treated with mycophenolate mofetil: A novel case report.
CONCLUSION: In SLE complicated by PAH/IP, reports on the efficacy of MMF are scarce, and our findings suggested that MMF may be a treatment option in such cases. PMID: 32914681 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 10, 2020 Category: Rheumatology Authors: Nawata M, Nagayasu A, Fujita Y, Nawata A, Saito K, Tanaka Y Tags: Lupus Source Type: research

A cat's scratch or a wolf's bite?
Abstract Bartonella henselae endocarditis mimicking systemic vasculitis has been reported in patients with valvulopathy. Herein, we describe a patient with B. henselae endocarditis involving a prosthetic pulmonic valve with positive anti-dsDNA antibodies misdiagnosed with systemic lupus erythematosus (SLE) based on the revised classification SLE criteria. PMID: 32903135 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 8, 2020 Category: Rheumatology Authors: Shmuely H, Chernin G, Giladi M, Zimhony O, Miller EB Tags: Lupus Source Type: research

Association of anti-NR2 and U1RNP antibodies with neurotoxic inflammatory mediators in cerebrospinal fluid from patients with neuropsychiatric systemic lupus erythematosus.
CONCLUSIONS: CSF anti-NR2 and anti-U1RNP Abs have different effects on the elevation of CSF IM levels in patients with NPSLE. Additional effect of anti-U1RNP Abs on anti-NR2 Ab-mediated NP manifestation, however, was not recognized in our study. PMID: 32883159 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 2, 2020 Category: Rheumatology Authors: Kondo-Ishikawa S, Fujii T, Ishigooka N, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Ohmura K, Mimori T Tags: Lupus Source Type: research

Sixteenth international congress on antiphospholipid antibodies task force. Report on obstetric antiphospholipid syndrome.
This report will address evidence-based medicine related to obstetric APS, including limitations on our current management, the relationship between antibodies against domain 1 of β2GPI and obstetric morbidity, hydroxychloroquine use in patients with obstetric APS and factors associated with thrombosis after obstetric APS. Finally, future directions for better understanding this complex condition are also reported by the Task Force coordinators. PMID: 32883160 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 2, 2020 Category: Rheumatology Authors: de Jesús GR, Benson AE, Chighizola CB, Sciascia S, Branch DW Tags: Lupus Source Type: research

Factors associated with quality of life in cutaneous lupus erythematosus using the Revised Wilson and Cleary Model.
Abstract OBJECTIVES: The purpose of this study was to characterize the impact of cutaneous lupus erythematosus (CLE) in adults and identify the clinical and non-clinical factors associated with quality of life (QoL), using the Revised Wilson and Cleary Model. METHODS: 101 patients diagnosed with CLE were included in this cross-sectional study. QoL was measured with the Cutaneous Lupus Erythematosus Quality of Life (CLEQoL) scale and disease activity and damage with the Cutaneous Lupus Activity and Severity Index (CLASI). Patient demographics, clinical, and disease characteristics were also collected. Descript...
Source: Lupus - September 2, 2020 Category: Rheumatology Authors: Ogunsanya ME, Cho SK, Hudson A, Chong BF Tags: Lupus Source Type: research

Erratum to urinary C3d is elevated in patients with active lupus nephritis and a fall in its level after 3 months predicts response at 6 months on follow up.
Authors: PMID: 32878555 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 2, 2020 Category: Rheumatology Tags: Lupus Source Type: research

The Arabic LupusPRO: A Cross-Cultural Validation of a Disease-Specific Patient-Reported Outcome Tool for Quality of Life in Lupus Patients.
CONCLUSION: The Arabic version of LupusPRO v1.8 is a reliable and valid tool for measuring quality of life among Arabic speaking SLE patients. PMID: 32878556 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 1, 2020 Category: Rheumatology Authors: Elkaraly NE, Nasef SI, Omar AS, Fouad AM, Jolly M, Mohamed AE Tags: Lupus Source Type: research

Lupus nephritis-related issues during COVID-19 pandemic quarantine.
va CA PMID: 32878557 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - September 1, 2020 Category: Rheumatology Authors: Pedrosa T, Kupa LVK, Aikawa NE, Pasoto SG, Bonfá E, Silva CA Tags: Lupus Source Type: research

The multi-targets mechanism of hydroxychloroquine in the treatment of systemic lupus erythematosus based on network pharmacology.
CONCLUSIONS: Our research provides protein targets affected by HCQ in the treatment of SLE. Three key targets (CDK2, ESR1 and CDK1) involving 1766 proteins become the multi-targets mechanism of HCQ in the treatment of SLE. As well, the research also provides a new idea for introducing network pharmacology into the evaluation of the drugs with multi-targets in dermatology. PMID: 32854577 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - August 26, 2020 Category: Rheumatology Authors: Xie B, Geng Q, Xu J, Lu H, Luo H, Hu Y, Song X Tags: Lupus Source Type: research

A case of recombinant human follitropin alfa-induced subacute cutaneous lupus erythematosus presenting with erythema multiforme-like lesion.
PMID: 32847460 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - August 25, 2020 Category: Rheumatology Authors: Wang L, Chen SY, Ju Q Tags: Lupus Source Type: research

Ambulatory blood pressure in patients with systemic lupus erythematosus: Association with markers of immune activation.
Conclusion: In patients with SLE, nocturnal blood pressure and attenuated nocturnal blood pressure dipping were significantly associated with several innate and adaptive immune system biomarkers. PMID: 32842866 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - August 24, 2020 Category: Rheumatology Authors: Carranza-Leon DA, Oeser A, Wu Q, Stein CM, Ormseth MJ, Chung CP Tags: Lupus Source Type: research

Corrigendum to Profiling of non-criteria antiphospholipid antibodies in patients with SLE: Differentiation of thrombotic SLE patients and risk of recurrence of thrombosis.
Authors: PMID: 32842867 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - August 24, 2020 Category: Rheumatology Tags: Lupus Source Type: research

Bullous lupus as the first manifestation of systemic lupus erythematosus in the pediatric population: A diagnostic challenge in daily practice.
CONCLUSIONS: In this pediatric series, BSLE tends to have a monophasic behavior associated with neuropsychiatric, skeletal, and hematological involvement in 40% of the patients, and with good prognosis. PMID: 32842868 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - August 24, 2020 Category: Rheumatology Authors: Torres Saavedra FA, Campo LR, Mendez MV, Barreneche NM, Suaza GAV, Restrepo JDR, Martinez-Gomez M Tags: Lupus Source Type: research