Factors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort.
cute;n-Díaz R, Alarcón GS, Pons-Estel BA Abstract AIM: The aim of this study was to identify factors predictive of serious infections over time in patients with systemic lupus erythematosus (SLE). METHODS: A multi-ethnic, multi-national Latin American SLE cohort was studied. Serious infection was defined as one that required hospitalization, occurred during a hospitalization or led to death. Potential predictors included were sociodemographic factors, clinical manifestations (per organ involved, lymphopenia and leukopenia, independently) and previous infections at baseline. Disease activity (SLE...
Source: Lupus - July 10, 2019 Category: Rheumatology Authors: Pimentel-Quiroz VR, Ugarte-Gil MF, Harvey GB, Wojdyla D, Pons-Estel GJ, Quintana R, Esposto A, García MA, Catoggio LJ, Cardiel MH, Barile LA, Amigo MC, Sato EI, Bonfa E, Borba E, Lavras Costallat LT, Neira OJ, Massardo L, Guibert-Toledano M, Chacón-Día Tags: Lupus Source Type: research

Choroidal thickness, area and vascular analysis with automated binarization of patients with juvenile systemic lupus erythematosus.
PMID: 31291844 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - July 10, 2019 Category: Rheumatology Authors: Chay IW, Tan CS Tags: Lupus Source Type: research

Differences in clinico-pathological characteristics and outcomes between proteinase 3-ANCA positivity and myeloperoxidase-ANCA positivity in lupus nephritis.
Abstract BACKGROUND: Owing to the low prevalence of anti-neutrophil cytoplasmic antibodies (ANCA) in lupus nephritis (LN), there is no study about the differences between proteinase 3 (PR3)-ANCA positivity and myeloperoxidase (MPO)-ANCA positivity in LN until now. METHODS: Here we perform a retrospective study to determine whether there are differences in clinic-pathological characteristics and renal outcomes between PR3-ANCA-positive LN patients and MPO-ANCA-positive LN patients. RESULTS: A total of 26 (27.4%) PR3-ANCA-positive LN patients and 69 (72.6%) MPO-ANCA-positive LN patients (p 
Source: Lupus - July 10, 2019 Category: Rheumatology Authors: Li C, Wang JJ, Zhou ML, Liang DD, Yang J, Zhu HX, Hu WX, Zhang HT Tags: Lupus Source Type: research

Analysis of HLA-G expression in renal tissue in lupus nephritis: a pilot study.
CONCLUSION: This study demonstrates that HLA-G is expressed in renal tissue in LN. Our retrospective data suggest that its expression could correlate with response to treatment. PMID: 31291846 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - July 10, 2019 Category: Rheumatology Authors: Foschi V, Bortolotti D, Doyle AF, Stratigou V, Stephens L, Trivedi P, Rinaldi R, Padovan M, Bortoluzzi A, Lightstone L, Cairns TD, Botto M, Cook TH, Rizzo R, Govoni M, Pickering MC Tags: Lupus Source Type: research

Usefulness of soluble CD163 as a biomarker for macrophage activation syndrome associated with systemic lupus erythematosus.
Abstract OBJECTIVE: We aimed to study the usefulness of serum soluble CD163 (sCD163) as a biomarker for macrophage activation syndrome (MAS) associated with systemic lupus erythematosus (SLE). METHODS: Serum sCD163 levels were retrospectively measured by enzyme-linked immunosorbent assay for SLE patients associated with MAS (SLE-MAS), lupus nephritis (LN), or autoimmune hemolytic anemia (AIHA) and/or immune thrombocytopenia (ITP) and healthy controls (HCs). Posttreatment samples were also evaluated in the available SLE-MAS patients. The associations between serum sCD163 levels and clinical information were st...
Source: Lupus - June 29, 2019 Category: Rheumatology Authors: Nishino A, Katsumata Y, Kawasumi H, Hirahara S, Kawaguchi Y, Yamanaka H Tags: Lupus Source Type: research

Increased blood pressure visit-to-visit variability in patients with systemic lupus erythematosus: association with inflammation and comorbidity burden.
Abstract BACKGROUND: Blood pressure visit-to-visit variability is a novel risk factor for deleterious long-term cardiac and renal outcomes in the general population. We hypothesized that patients with systemic lupus erythematosus (SLE) have greater blood pressure visit-to-visit variability than control subjects and that blood pressure visit-to-visit variability is associated with a higher comorbidity burden. METHODS: We studied 899 patients with SLE and 4172 matched controls using de-identified electronic health records from an academic medical center. We compared blood pressure visit-to-visit variability mea...
Source: Lupus - June 20, 2019 Category: Rheumatology Authors: Reese T, Dickson AL, Shuey MM, Gandelman JS, Barnado A, Barker KA, Neal JE, Khan OA, Dupont WD, Stein CM, Chung CP Tags: Lupus Source Type: research

Spectrum of cutaneous lupus erythematosus in South Africans with systemic lupus erythematosus.
We describe the prevalence and spectrum of lupus-specific (cutaneous lupus erythematosus) and non-specific cutaneous features amongst mostly black South Africans with systemic lupus erythematosus. PATIENTS AND METHODS: A retrospective record review of 298 South Africans (262 blacks and 36 non-blacks) with systemic lupus erythematosus was carried out. Cutaneous features were classified according to the Gilliam and Sontheimer classification of cutaneous lupus. RESULTS: Most (81.5%) patients were black African females. The mean (SD) age at diagnosis and follow-up duration were 35.0 (11.8) and 8.0 (5.9) years, respec...
Source: Lupus - June 19, 2019 Category: Rheumatology Authors: Koch K, Tikly M Tags: Lupus Source Type: research

Prognostic markers of lymphoma development in primary Sj ögren syndrome.
Prognostic markers of lymphoma development in primary Sjögren syndrome. Lupus. 2019 Jun 19;:961203319857132 Authors: Retamozo S, Brito-Zerón P, Ramos-Casals M Abstract Sjögren syndrome is a systemic autoimmune disease that principally affects women between the fourth and sixth decades of life who present with sicca symptomatology caused by dryness of the main mucosal surfaces. The clinical spectrum of Sjögren syndrome extends from dryness to systemic involvement. Since 1978, Sjögren syndrome has been closely associated with an enhanced risk of lymphoma, one of the most sever...
Source: Lupus - June 19, 2019 Category: Rheumatology Authors: Retamozo S, Brito-Zerón P, Ramos-Casals M Tags: Lupus Source Type: research

Aquaporin-4 IgG antibody-related disorders in patients with juvenile systemic lupus erythematosus.
CONCLUSIONS: The findings of this study indicate that some patients with juvenile systemic lupus erythematosus develop antibodies against aquaporin-4 and may be at risk of developing a neurological clinical phenotype. We suggest that all juvenile systemic lupus erythematosus patients should be systematically screened for the presence of AQP4-Ab and this may help identify a high risk for neurological involvement in juvenile systemic lupus erythematosus. PMID: 31213132 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - June 18, 2019 Category: Rheumatology Authors: Moraitis E, Stathopoulos Y, Hong Y, Al-Obaidi M, Mankad K, Hacohen Y, Sen D, Hemingway C, Eleftheriou D Tags: Lupus Source Type: research

Clinical features, outcomes and risk factors for posterior reversible encephalopathy syndrome in systemic lupus erythematosus: a case-control study.
CONCLUSIONS: PRES may be a reversible neurological deficit in patients with SLE other than neuropsychiatric lupus. Our results indicate two new risk factors for PRES and that PRES is associated with a higher mortality rate. PMID: 31208267 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - June 17, 2019 Category: Rheumatology Authors: Cui HW, Lei RY, Zhang SG, Han LS, Zhang BA Tags: Lupus Source Type: research

Direct cost of lupus care in the developing world: the case of Colombia.
CONCLUSIONS: The direct cost of lupus care in the developing world may be higher than expected; in addition, access to healthcare may not be equal for the entire population. PMID: 31204587 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - June 15, 2019 Category: Rheumatology Authors: Prada SI, Perez AM, Nieto-Aristizábal I, Tobón GJ Tags: Lupus Source Type: research

Real-world electronic health record identifies antimalarial underprescribing in patients with lupus nephritis.
Abstract Antimalarials (AMs) reduce disease activity and improve survival in patients with systemic lupus erythematosus (SLE), but studies have reported low AM prescribing frequencies. Using a real-world electronic health record cohort, we examined if patient or provider characteristics impacted AM prescribing. We identified 977 SLE cases, 94% of whom were ever prescribed an AM. Older patients and patients with SLE nephritis were less likely to be on AMs. Current age (odds ratio = 0.97, p 
Source: Lupus - June 12, 2019 Category: Rheumatology Authors: Xiong WW, Boone JB, Wheless L, Chung CP, Crofford LJ, Barnado A Tags: Lupus Source Type: research

Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study.
The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions -986 (G/A), -602 (G/A), -4 (A/G) and SNP C/T (rs3124954) located in intron 1, with susceptibility to pSLE in Egyptian children and adolescents. METHODS: This was a multicenter study of 280 patients diagnosed with pSLE, and 280 well-matched healthy controls. The FCN2 promoter polymorphisms at -986 G/A (rs3124952), -602 G/A (rs3124953), -4 A/G (rs17514136) and SNP C/T (rs3124954) located in intron 1 were genotyped by polymerase chain reaction, while serum ficolin-2 levels were assessed using enzyme-linke...
Source: Lupus - June 10, 2019 Category: Rheumatology Authors: Elkoumi MA, Emam AA, Allah MAN, Sherif AH, Abdelaal NM, Mosabah A, Zakaria MT, Soliman MM, Salah A, Sedky YM, Mashali MH, Elashkar SSA, Hafez SFM, Hashem MIA, Elshreif AM, Youssef M, Fahmy DS, Sallam MM, Nawara AM, Elgohary EA, Ahmed AA, Fahim MS, Fawzi M Tags: Lupus Source Type: research

Ten-year fracture risk by FRAX and osteoporotic fractures in patients with systemic autoimmune diseases.
This study aimed to compare the applicability of FRAX for autoimmune disease patients. This retrospective study recruited rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS) patients with bone mineral density (BMD) tests. Patients with any osteoporotic fractures were identified. Taiwan-specific FRAX with and without BMD were then calculated. In total, 802 patients (451 RA, 233 SLE and 118 pSS) were enrolled in this study. The cumulative incidences of osteoporotic fractures in the RA, SLE and pSS patients were 43.0%, 29.2% and 33.1%, respectively. For those with a previous o...
Source: Lupus - June 9, 2019 Category: Rheumatology Authors: Lai EL, Huang WN, Chen HH, Hsu CY, Chen DY, Hsieh TY, Hung WT, Lin CT, Lai KL, Tang KT, Chen YM, Chen YH Tags: Lupus Source Type: research

A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus.
Abstract Hydroxychloroquine (HCQ) has been used to treat systemic lupus erythematosus (SLE) in Japan since 2015. We herein report a case of SLE that developed generalized pustular psoriasis (GPP) following the administration of HCQ. Twenty-one days after the HCQ treatment, a pustular rash with itching appeared on the auricle, scalp, and forearm, and spread rapidly to the face and body trunk with a high fever and arthralgia. Skin biopsy showed pustule formation under the cornified layer, neutrophil infiltration, the destruction of keratinocytes, and spongiform pustules of Kogoj. The patient was diagnosed with GPP. ...
Source: Lupus - June 5, 2019 Category: Rheumatology Authors: Shindo E, Shikano K, Kawazoe M, Yamamoto T, Kusunoki N, Hashimoto Y, Nanki T Tags: Lupus Source Type: research

Interleukin-23 deficiency alters thymic selection in lupus-prone mice.
Abstract We have previously reported that IL-23 receptor deficiency in MRL. lpr mice ameliorates lupus by altering the balance of pro- and anti-inflammatory cytokines in secondary lymphoid organs. As IL-23 may also impact thymic selection, we evaluated the effect of IL-23 on thymic T cell development in lupus-prone mice. We generated IL-23p19-deficient MRL. lpr mice and harvested their thymus at 8 weeks of age. We found that the late stage double negative DN4 population was increased in IL-23p19-/- MRL. lpr mice when compared to IL-23p19+/+ MRL. lpr mice. Despite this, mature thymocytes (CD24-TCRβ+) were decr...
Source: Lupus - June 5, 2019 Category: Rheumatology Authors: Dai H, Kyttaris VC Tags: Lupus Source Type: research

Cost-effectiveness of a peer mentoring intervention to improve disease self-management practices and self-efficacy among African American women with systemic lupus erythematosus: analysis of the Peer Approaches to Lupus Self-management (PALS) pilot study.
CONCLUSION: These findings suggest that the PALS intervention was effective in improving patient-level factors and was cost-effective. Future research will need to validate these findings in a larger sample. PMID: 31166867 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - June 5, 2019 Category: Rheumatology Authors: Williams EM, Dismuke CL, Faith TD, Smalls BL, Brown E, Oates JC, Egede LE Tags: Lupus Source Type: research

Changing hospitalization trends for systemic lupus erythematosus and rheumatoid arthritis in England.
Abstract OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic, multisystemic, immune-mediated disorder associated with a substantial hospitalization risk. As a comparatively rare disease, there is a sparsity of research examining the burden of hospital admission in the contemporary era. We aim to describe national trends in hospitalization rates in England between 1998 and 2015 for SLE, using rheumatoid arthritis (RA) and general population rates as comparison cohorts for benchmarking. METHODS: Hospital admission rates, emergency and day-case admission rates, length of stay and bed days used were calcu...
Source: Lupus - June 4, 2019 Category: Rheumatology Authors: Hannah J, Galloway J, Kaul A Tags: Lupus Source Type: research

Prevalence of cognitive impairment using the Montreal Cognitive Assessment questionnaire among patients with systemic lupus erythematosus: a cross-sectional study at two tertiary centres in Malaysia.
CONCLUSION: Over one-third of patients with SLE in our cohort were found to have MCI. Risk factors included male gender, lower educational level, higher pain score and presence of anticardiolipin IgM. Physicians are encouraged to perform routine screening to detect cognitive dysfunction in patients with SLE in their clinical practice as part of a more comprehensive management. PMID: 31159651 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - June 4, 2019 Category: Rheumatology Authors: Kanapathy A, Nik Jaafar NR, Shaharir SS, Chan LF, Rozita M, Ch'ng SS Tags: Lupus Source Type: research

Differential tissue expression of erythroblast macrophage protein in a MRL/lpr mouse model of lupus.
CONCLUSIONS: Our data showed that EMP is ubiquitously expressed in macrophages at all of the tissues of the lupus and control mice. However, the expression of EMP in bone marrow and liver tissues of lupus mice was higher than in the control mice, which indicates that EMP may be important in the development of SLE. PMID: 31132907 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 27, 2019 Category: Rheumatology Authors: Fan H, Li N, Fan P, Hu X, Liang K, Zhang S, Cheng X, Wu Y Tags: Lupus Source Type: research

Menorrhagia: an underappreciated problem in pre-menopausal women with systemic lupus erythematosus.
PMID: 31132915 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 27, 2019 Category: Rheumatology Authors: Wincup C, McDonnell TCR, Rahman A Tags: Lupus Source Type: research

Obstetric outcomes in patients with primary thrombotic and obstetric antiphospholipid syndrome and its relation to the antiphospholipid antibody profile.
haireti R Abstract INTRODUCTION: Previous studies suggested different obstetric outcomes between patients with thrombotic or obstetric antiphospholipid syndrome, but the data are inconclusive. AIMS: To investigate obstetric outcomes and their relation to the antiphospholipid antibody profile in primary thrombotic or obstetric antiphospholipid syndrome patients and compare those to a control population. MATERIALS AND METHODS: A retrospective single-centre study on a cohort of 30 pregnant women with primary antiphospholipid syndrome treated at Karolinska University Hospital Solna, Sweden between 2000 and 2...
Source: Lupus - May 27, 2019 Category: Rheumatology Authors: Högdén A, Antovic A, Berg E, Bremme K, Chaireti R Tags: Lupus Source Type: research

Four-year follow-up of two patients on maintenance therapy with fondaparinux and mycophenolate mofetil for microthrombotic antiphospholipid syndrome.
CONCLUSIONS: As described in our small cohort, patients with APS who suffer from microthrombotic arterial disease may benefit from maintenance therapy of anticoagulation with fondaparinux and immunosuppression with MMF, an approach which may be worthy of further trial. Fondaparinux does not require attention to diet, monitoring, and cumbersome bridging that is typical of warfarin therapy. MMF provides immunosuppression while sparing the side effects of steroid treatment. PMID: 31122135 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 24, 2019 Category: Rheumatology Authors: Baron BW, Baron JM Tags: Lupus Source Type: research

Association between hydroxychloroquine levels and disease activity in a predominantly Hispanic systemic lupus erythematosus cohort.
Abstract OBJECTIVES: Hydroxychloroquine (HCQ) is a key therapy in systemic lupus erythematosus (SLE). Medication non-adherence is reported in up to 80% of lupus patients and results in increased morbidity, mortality, and health care utilization. HCQ levels are a sensitive and reliable method to assess medication adherence. Our study evaluated the role of HCQ level measurement in routine clinical care and its association with disease activity in a predominantly Hispanic population. METHODS: SLE patients from the Columbia University Lupus cohort treated with HCQ for ≥ 6 months and reporting med...
Source: Lupus - May 24, 2019 Category: Rheumatology Authors: Geraldino-Pardilla L, Perel-Winkler A, Miceli J, Neville K, Danias G, Nguyen S, Dervieux T, Kapoor T, Giles J, Askanase A Tags: Lupus Source Type: research

Spontaneous recovery from suppressed B cell production and proliferation caused by intrauterine azathioprine exposure in the fetal period.
PMID: 31126211 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 24, 2019 Category: Rheumatology Authors: Kaneko K, Kawai T, Watanabe N, Wada Y, Onodera M, Murashima A Tags: Lupus Source Type: research

Retiform non-blanchable purpuric plaques in a patient with systemic lupus erythematosus.
We present an unusual case of LV occurring in the setting of acute kidney injury secondary to lupus nephritis. It is important to differentiate LV from vasculitis as the treatment recommendation centers on anticoagulation therapy rather than immunosuppression. Additionally, antiphospholipid syndrome should be ruled out in cases of systemic lupus erythematosus with LV due to risk of thrombotic events. PMID: 31126212 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 24, 2019 Category: Rheumatology Authors: Grinnell M, Bath A, DiMaio D, Hultgren T, Hearth-Holmes M Tags: Lupus Source Type: research

Domain I of β2GPI is capable of blocking serum IgA antiphospholipid antibodies binding in vitro: an effect enhanced by PEGylation.
CONCLUSIONS: Inhibition of IgA aβ2GPI by DI is possible and can be enhanced by biochemical modification in a subset of patients. PMID: 31126213 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 24, 2019 Category: Rheumatology Authors: Albay A, Artim-Esen B, Pericleous C, Wincup C, Giles I, Rahman A, McDonnell T Tags: Lupus Source Type: research

Lupus is associated with poorer outcomes after primary total hip arthroplasty.
CONCLUSIONS: Lupus was associated with a higher risk of implant infection, transfusion, discharge to an inpatient facility and higher hospital charges post-primary THA. Insight into modifiable factors associated with these outcomes may improve outcomes in patients with lupus undergoing THA. PMID: 31117886 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 22, 2019 Category: Rheumatology Authors: Singh JA, Cleveland JD Tags: Lupus Source Type: research

Successful short desensitization for the eruption of hydroxychloroquine.
PMID: 31112453 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 21, 2019 Category: Rheumatology Authors: Hayami T, Tanaka T, Fujimoto N Tags: Lupus Source Type: research

Clinical characteristics of pediatric cutaneous lupus erythematosus: experience from a tertiary referral center in Korea.
This study revealed unique characteristics of pediatric CLE, further warranting a comprehensive review among various ethnicities to understand the wide spectrum of CLE in the pediatric population. PMID: 31112454 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 21, 2019 Category: Rheumatology Authors: Lee SK, Baek J, Roh JY, Kim HJ Tags: Lupus Source Type: research

Pregnancy outcome in women with active and inactive lupus nephritis: A prospective cohort study.
In conclusion, lupus nephritis, per se, is not a risk factor for poor pregnancy outcome; rather, it is the lupus nephritis activity at the onset of pregnancy. PMID: 31084235 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 13, 2019 Category: Rheumatology Authors: Attia DH, Mokbel A, Haggag HM, Naeem N Tags: Lupus Source Type: research

Assessing the relative impact of lupus nephritis on mortality in a population-based systemic lupus erythematosus cohort.
CONCLUSION: In this population-based SLE cohort, we found that LN was associated with increased morbidity and mortality, whereas SLE patients who did not develop LN had good overall prognoses regarding survival. PMID: 31072277 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 9, 2019 Category: Rheumatology Authors: Reppe Moe SE, Molberg Ø, Strøm EH, Lerang K Tags: Lupus Source Type: research

Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus.
CONCLUSION: HCQ may improve organ involvement in SLE by modulating S100 protein levels, especially in patients with renal or skin involvement. PMID: 31068068 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 8, 2019 Category: Rheumatology Authors: Wakiya R, Kameda T, Ueeda K, Nakashima S, Shimada H, Mansour MF, Kato M, Miyagi T, Miyatake N, Kadowaki N, Dobashi H Tags: Lupus Source Type: research

Soluble TNF-R1, VEGF and other cytokines as markers of disease activity in systemic lupus erythematosus and lupus nephritis.
Abstract BACKGROUND: Current non-invasive methods of assessing disease activity in systemic lupus erythematosus (SLE) are of limited sensitivity and specificity. Testing includes acute phase markers, autoantibodies and complement levels. Although measurements of dsDNA antibodies and complement C3/C4 levels are routine, they remain of limited value. Improved blood and urine markers may help in early detection of flare, distinction between flare and chronic damage, and monitoring response to therapy. METHODS: A total of 87 patients with SLE were tested for the following cytokines in serum and urine: monocyte ch...
Source: Lupus - May 2, 2019 Category: Rheumatology Authors: Adhya Z, El Anbari M, Anwar S, Mortimer A, Marr N, Karim MY Tags: Lupus Source Type: research

Breastfeeding in the systemic lupus erythematosus patient.
PMID: 31046571 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 2, 2019 Category: Rheumatology Authors: Francis A, Nusbaum J, Melendez Torres A, Spruill T, Buyon J, Mehta-Lee S Tags: Lupus Source Type: research

The diagnostic accuracies of the 2012 SLICC criteria and the proposed EULAR/ACR criteria for systemic lupus erythematosus classification are comparable.
ouml;wall C Abstract In a joint effort, the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) recently proposed new criteria for the classification of systemic lupus erythematosus (SLE) with the overarching goal to identify potential participants for clinical studies. Herein, we present the first independent evaluation of these criteria in comparison with older classification grounds using an adult Scandinavian study population of confirmed SLE cases and individuals with SLE-mimicking conditions. We included 56 confirmed SLE cases meeting the 1982 ACR criteria (ACR-82) and/o...
Source: Lupus - May 2, 2019 Category: Rheumatology Authors: Dahlström Ö, Sjöwall C Tags: Lupus Source Type: research

Predictors for seasonal influenza vaccination and reasons for inadequate vaccination coverage against a broad spectrum of vaccine-preventable diseases: a cross-sectional study among a Brazilian cohort of adult patients with systemic lupus erythematosus.
PMID: 31042124 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 1, 2019 Category: Rheumatology Authors: Vieira de Rezende RP, Mattos GA, de Mello Leal Augusto R, Machado Gayer CR, Mendes Klumb E Tags: Lupus Source Type: research

Right ventricular thrombus in a case of neonatal lupus: case report.
We reported a neonatal lupus of a Sjogren's syndrome mother with recurrent miscarriage secondary to antiphospholipid syndrome; seronegative to anticardiolipin antibodies, lupus anticoagulant and B2GP1. She was serologically positive to antiphosphatidylethanolamine and antiprothrombin antibodies, anti-SSA/Ro and anti-SSB/La. The neonate developed neonatal lupus complicated with right ventricular thrombus assumed to be induced by maternal transmission of antiphosphatidylethanolamine and antiprothrombin antibodies, treated successfully with tissue plasminogen activator and warfarin. PMID: 31042125 [PubMed - as supplied b...
Source: Lupus - May 1, 2019 Category: Rheumatology Authors: Elnady B, Alqarni MM, Mostafa MA, Fouda ES Tags: Lupus Source Type: research

Oxidative stress and vitamin D receptor BsmI gene polymorphism in Egyptian children with systemic lupus erythematosus: a single center study.
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown exact etiology. Vitamin D receptor gene ( VDR) and oxidative stress play important roles in the pathogenesis of SLE. Here we investigated the genotypes and allelic frequencies of VDR BsmI polymorphism as well as their relationship with oxidative stress markers in Egyptian SLE children. We conducted a cross-sectional comparative study at Mansoura University Children's Hospital, Egypt from 2014 to 2018 including 100 SLE children and 100 controls. We investigated both groups for VDR BsmI polymorphism using polymerase chain reaction. Oxi...
Source: Lupus - May 1, 2019 Category: Rheumatology Authors: Fouad H, Yahia S, Elsaid A, Hammad A, Wahba Y, El-Gilany AH, Abdel-Aziz AF Tags: Lupus Source Type: research

A systemic lupus erythematosus patient with thunderclap headache: reversible cerebral vasoconstriction syndrome.
Abstract Headaches are common in patients with systemic lupus erythematosus (SLE). It is important to identify the exact cause of headaches in SLE to avoid unnecessary steroid or immunosuppressive therapy like in neuropsychiatric SLE. A 35-year-old woman with SLE suddenly developed severe headache. Magnetic resonance angiography showed multifocal segmental narrowing of cerebral arteries, suggestive of central nervous system vasculitis. However, lack of abnormal enhancement in vessel wall imaging indicated reversible cerebral vasoconstriction syndrome (RCVS) rather than central nervous system vasculitis. The patien...
Source: Lupus - May 1, 2019 Category: Rheumatology Authors: Chung SW, Lee KM, Heo SH, Ra R, Hong SJ, Yang HI, Lee SH, Song R, Lee YA Tags: Lupus Source Type: research

A review of the evidence and cost of therapies for cutaneous lupus erythematosus.
This article seeks to provide an overview of the efficacy, safety, and cost of therapeutic options for CLE. PMID: 31042129 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - May 1, 2019 Category: Rheumatology Authors: Rosen JD, Paul S, Maderal A Tags: Lupus Source Type: research

Distinctive features of positive anti-cell antibody tests (indirect immunofluorescence on HEp-2 cells) in patients with non-autoimmune diseases.
The objective of this study was to determine whether characteristics of positive results in the indirect immunofluorescence assay on HEp-2 cells for anti-cell antibodies (HEp-2 IFA) differ between patients with non-autoimmune diseases (NADs) and patients with systemic autoimmune rheumatic diseases (SARDs). METHODS: Cross-sectional observational study comparing HEp-2 IFA test results in three groups: (a) 558 NAD patients comprising four subgroups (cancer ( n = 95), infectious diseases ( n = 148), psychiatric diseases ( n = 163), common non-infectious chronic diseases ( n&thinsp...
Source: Lupus - April 26, 2019 Category: Rheumatology Authors: Agustinelli RA, Rodrigues SH, Mariz HA, Prado MS, Andrade LEC Tags: Lupus Source Type: research

Diet and lupus: what do the patients think?
CONCLUSIONS: This project successfully gathered patient information regarding diet and systemic lupus erythematosus over a short timeframe using an anonymous social media platform. The survey provided evidence that patients support further research and potential diet intervention studies investigating the effect of diet on the symptoms of systemic lupus erythematosus. PMID: 31027464 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - April 26, 2019 Category: Rheumatology Authors: Robinson GA, Mcdonnell T, Wincup C, Martin-Gutierrez L, Wilton J, Kalea AZ, Ciurtin C, Pineda-Torra I, Jury EC Tags: Lupus Source Type: research

Elevated levels of IL-24 in systemic lupus erythematosus patients.
CONCLUSION: The inflammatory cytokine correlated with SLE disease activity, and may be involved in this disease pathogenesis. PMID: 31023128 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - April 25, 2019 Category: Rheumatology Authors: Li RC, Guo J, Su LC, Huang AF Tags: Lupus Source Type: research

Corticosteroid-associated lupus pancreatitis: a case series and systematic review of the literature.
CONCLUSION: In a small but substantial proportion of patients with lupus who develop pancreatitis, it occurs within days to weeks of starting medium-to-high dose corticosteroids. Many of these patients continue to receive corticosteroids, and some receive more aggressive immunosuppression. However, they have significant mortality, and further studies are required to identify appropriate treatment in this subgroup of patients. PMID: 31023131 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - April 25, 2019 Category: Rheumatology Authors: Dwivedi P, Kumar RR, Dhooria A, Adarsh MB, Malhotra S, Kakkar N, Naidu S, Sharma SK, Sharma A, Jain S, Dhir V Tags: Lupus Source Type: research

Photosensitivity and photoprotection in patients with lupus erythematosus.
Abstract Lupus erythematosus (LE) represents a spectrum of inflammatory autoimmune disease comprising varying clinical entities ranging from primary cutaneous to systemic disease. There is a clear relationship between ultraviolet irradiation (UVR) and the clinical manifestations of LE in both adult and pediatric populations. Although it has been established that UVR exacerbates pre-existing LE, it remains unclear whether UVR induces the development of the disease. This review serves to discuss effective photoprotective measures in LE and describe the pathogenic relationship of UVR and LE. PMID: 31023132 [PubM...
Source: Lupus - April 25, 2019 Category: Rheumatology Authors: Ahluwalia J, Marsch A Tags: Lupus Source Type: research

Association between the interferon regulatory factor 5 rs2004640 functional polymorphism and systemic lupus erythematosus: an updated meta-analysis.
Abstract OBJECTIVE: The aim of this study is to determine whether the functional interferon regulatory factor 5 ( IRF5) polymorphism rs2004640 is associated with susceptibility to systemic lupus erythematosus (SLE) in multiple ethnic populations. METHODS: A meta-analysis was conducted on the T allele of the IRF5 rs2004640 polymorphism in all study participants as well as each ethnic population. RESULTS: Twenty research articles that included 28 comparative studies of 20,892 patients and 24,930 controls were included in the meta-analysis. The Asian population had a much lower prevalence of the T allele th...
Source: Lupus - April 24, 2019 Category: Rheumatology Authors: Bae SC, Lee YH Tags: Lupus Source Type: research

Protein S deficiency revealed by skin necrosis in a patient with lupus.
Abstract Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had not received warfarin and without APL antibodies who developed extensive skin necrosis due to protein S deficiency. It is important to investigate protein S deficiency in patients with lupus and extensive skin ulcers as it is a sign of arterial thrombosis and venous thromboembolism. PMI...
Source: Lupus - April 24, 2019 Category: Rheumatology Authors: Plana-Pla A, Bielsa Marsol I, Ferrandiz Foraster C Tags: Lupus Source Type: research

Clinical, neuroimaging and immunological phenotype of South African neuropsychiatric systemic lupus erythematosus patients.
Abstract Neuropsychiatric systemic lupus erythematosus (NPSLE) is an important cause of morbidity and mortality. We undertook this observational retrospective study of patients with NPSLE who had brain magnetic resonance imaging (MRI) to determine the indications for MRI and the correlation of clinical and laboratory findings with MRI. We identified 83 NPSLE patients (84.3% women) seen at Inkosi Albert Luthuli Central Hospital in Durban, South Africa, between June 2003 and May 2017. The mean age at SLE diagnosis was 26.24 ± 12.81 years and the median interval to NPSLE was 11.0 (interquartile r...
Source: Lupus - April 24, 2019 Category: Rheumatology Authors: Mvambo N, Bhigjee AI, Mody GM Tags: Lupus Source Type: research

Renal transplantation for lupus nephritis: non-adherence and graft survival.
CONCLUSION: Poor adherence to immunosuppressive therapy is common and has been shown to associate with a trend towards increased graft failure in patients with LN requiring rTp. This is the first paper to report that shorter periods on dialysis prior to transplantation might lead to increased non-adherence in lupus patients. PMID: 30982400 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - April 13, 2019 Category: Rheumatology Authors: Ntatsaki E, Vassiliou VS, Velo-Garcia A, Salama AD, Isenberg DA Tags: Lupus Source Type: research