Forensic Science, Medicine, and Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A case of fatal poisoning caused by etomidate: evidence from pathological and toxicological analyses
This report describes a rare case of a 47-year-old man who died from acute intoxication after oral ingestion of liquid containing etomidate. The cause of death was conclusively attributed to etomidate based on a comprehensive investigation, including autopsy, histopathological examination, toxicological analysis, and biochemical analysis. This is the first reported case of a fatality solely resulting from the oral ingestion of etomidate, which can provide valuable insights for future forensic investigations involving etomidate poisoning. Therefore, it is imperative to share this case with the scientific community. (Source:...
Source: Forensic Science, Medicine, and Pathology - April 23, 2024 Category: Forensic Medicine Source Type: research

The time-dependent expression of FPR2 and ANXA1 in murine deep vein thrombosis model and its relation to thrombus age
In this study, we investigated the time-dependent expressions of formyl peptide receptor 2 (FPR2) and Annexin A1 (ANXA1) in a stasis-induced deep vein thrombosis (DVT) murine model, with the aim of obtaining useful information for thrombus age timing. A total of 75 ICR mice were randomly classified into thrombosis group and control group. In thrombosis group, a DVT model was established by ligating the inferior vena cava (IVC) of mice, and thrombosed IVCs were harvested at 1, 3, 5, 7, 10, 14, and 21  days after modeling. In control group, IVCs without thrombosis were taken as control samples. The expressions of FPR2 and A...
Source: Forensic Science, Medicine, and Pathology - April 23, 2024 Category: Forensic Medicine Source Type: research

Forensic Discrimination of condom lubricants using ATR-FTIR spectroscopy in combination with chemometrics- effect of matrices, pre-coital and post-coital conditions
In conclusion, this study presents a comprehensive approach to analysing condom lubricants, offering a potential breakthrough in the investigation of sexual assault cases, coupled with the ability to counter false accusations. (Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - April 19, 2024 Category: Forensic Medicine Source Type: research

Collagen and elastic fibers assessment of the human heart valves for age estimation in Thais using image analysis
AbstractThe study investigated the relationship between the histological compositions of the tricuspid, pulmonary, mitral, and aortic valves, and age. All 85 fresh human hearts were obtained with an age range between 20 and 90  years. The central area of the valves was conducted to analyze the density of collagen and elastic fibers by using an image analysis program. Neural network function in MATLAB was used for classification data and accuracy test of the age predictive model. Overall, a gradual increase in the density of collagen and elastic fibers was demonstrated with age in all valve types. The pulmonary valve cusps...
Source: Forensic Science, Medicine, and Pathology - April 18, 2024 Category: Forensic Medicine Source Type: research

A novel conservative technique to allow oral opening and overcome rigor mortis during medicolegal autopsy
This study presents a novel conservative technique to increase oral opening and overcome rigor mortis during medicolegal autopsy (MLA). The method proposes a myotomy of the temporalis and masseter muscles, taking advantage of the incisions of the cranial opening procedures, to achieve a significant oral opening ( ≥ 30 mm) in fresh cadavers with established rigor mortis without altering facial aesthetics. The study was performed on 48 individuals aged between 18 and 66 years (20 males and 28 females) who were autopsied at the Instituto Nacional de Patología Forense Dr. Sergio Sarita Valdez (Santo Doming o, Dominican R...
Source: Forensic Science, Medicine, and Pathology - April 17, 2024 Category: Forensic Medicine Source Type: research

Mechanical trauma in children and adolescents in Berlin
This study analyzes trauma mechanisms in deceased pediatric patients. Fatal pediatric trauma cases aged 0 –18 years who underwent forensic autopsy in the Federal State of Berlin, Germany, between 2008 until 2018 were enrolled in this retrospective study. Autopsy protocols were analyzed regarding demographic characteristics, trauma mechanisms, injury patterns, resuscitation measures, survival times as well as place, and cause of death. 71 patients (73% male) were included. Traffic accidents (40%) were the leading cause of trauma, followed by falls from height >  3 m (32%), railway accidents (13%), third party viol...
Source: Forensic Science, Medicine, and Pathology - April 16, 2024 Category: Forensic Medicine Source Type: research

Self-mutilation: a systematic review
AbstractSelf-mutilation lesions can represent a clinical diagnosis challenge for healthcare professionals, as patients do not admit to self-mutilation. This leads to failed diagnoses due to the similarity of this condition to other diseases. Searches on the subject were carried out at the PubMed, Peri ódicos Capes, Scopus, Science Direct and WoS databases, according to the following inclusion criteria: articles in English, Portuguese or Spanish, published from 2018 to June 2023, encompassing case reports, case series and literature reviews. Men are slight more affected by self-mutilation injurie s, also presenting the mos...
Source: Forensic Science, Medicine, and Pathology - April 13, 2024 Category: Forensic Medicine Source Type: research

A fatal misdiagnosis of page kidney – case report
AbstractPage kidney is a condition where external compression of the renal artery and renal parenchyma leads to subsequent ischaemia and activation of renin-angiotensin-aldosterone axis. A 42-year-old female with hirsutism, hypertension and diabetes was diagnosed with a right adrenal mass and underwent laparoscopic adrenalectomy. Her hypertension worsened postoperatively and was managed medically. Subsequently she developed a right flank pain on the fifth postoperative day and died suddenly the next day. Autopsy revealed a pale body with cushingoid appearance. Surgical scars were healthy. Internal examination of the abdome...
Source: Forensic Science, Medicine, and Pathology - April 13, 2024 Category: Forensic Medicine Source Type: research

Traumatic fractures in an early 19th century museum skeleton suggest the homicide of an old Munich character: the history of “Finessensepperl” (Finesse Joseph)
AbstractThe well preserved skeleton of Joseph Huber, a very well-known historical character of the 19th century Munich, also nicknamed “Finessen-Sepperl”, is the starting point of the reconstruction of life and death of this historical individual. He was known as apostilion d ´amour (love ’s messenger) of the Royal Bavarian capital with numerous comments and anecdotes and a few biographical sketches that indicate he remained well until the last few years of his life where requests for his duties lessened. The skeleton shows a small-sized male individual with almost complete loss of teeth, but otherwise very well-min...
Source: Forensic Science, Medicine, and Pathology - April 12, 2024 Category: Forensic Medicine Source Type: research

Recent trends in an uncommon method of carbon monoxide suicide
ConclusionCB suicide is perceived to be widely accessible and painless and is therefore becoming a popular suicide method. Monitoring future trends will be important to determine whether intervention is required. (Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - April 11, 2024 Category: Forensic Medicine Source Type: research

Acanthosis nigricans – a potentially useful clue to the presence of significant occult disease at autopsy
AbstractA 19-year-old male was found dead in his apartment. At autopsy he was morbidly obese (Body mass index; BMI – 40.5) with multiple areas of velvety pigmented thickening of the skin in folds around the neck, in the axillae, in the inframammary regions, over the anterior waistline and groin regions and over the dorsal aspects of the feet. These had the typical appearance of acanthosis nigricans. Internal e xamination revealed aspiration of gastric contents into the airways. Vitreous humour biochemistry showed markedly elevated levels of both glucose (62.9 mmol/L) and β-hydroxybutyrate (13.54 mmol/L). Death was, th...
Source: Forensic Science, Medicine, and Pathology - April 11, 2024 Category: Forensic Medicine Source Type: research

Determination of lamotrigine in human plasma by HPLC-PDA. Application to forensic samples
ConclusionA new HPLC method for the determination of lamotrigine in human plasma was developed and validated. A liquid-liquid extraction using small volumes of buffer and ethylacetate was optimized. The proposed method is suitable for forensic toxicological analysis. (Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - April 10, 2024 Category: Forensic Medicine Source Type: research

InDEL instability in two different tumoral tissues and its forensic significance
In conclusion, low InDel mutation rates compared to STR instability, make InDel analysis from paraffin blocks suitable for forensic genetic identification. However, researchers should keep in mind that there may be differences between the profiles of the tumoral tissues taken as reference and the actual case. In addition, by incorporating additional markers such as SNPs and microhaplotypes with low mutation rates into the study alongside Indels, researchers can significantly enhance the discrimination power in identification processes. (Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - April 3, 2024 Category: Forensic Medicine Source Type: research

Estimating dental age of New Zealand juveniles and subadults using Demirjian's method
AbstractReference data for dental age estimate is sparse in New Zealand (NZ), with only two contemporary studies. Te Moananui et al. (J For Sci. 53(2),2008) presented modified Demirjian percentile curves to estimate dental age of Pasifika, M āori, and European males and females (n = 1383), while Timmins et al. (Forensic Sci Med Pathol. 8:101–8, 2012) found the Demirjian method (1973) was valid for a smaller sample (n  = 200) of unknown ancestry. The study presented here sought to validate the Demirjian and the Te Moananui methods for a sample of the NZ population of unknown ancestry and a subgroup of known anc...
Source: Forensic Science, Medicine, and Pathology - April 3, 2024 Category: Forensic Medicine Source Type: research

Determining the manner of death in victims in drug-induced psychosis: a case of an atypical head stab wound
AbstractThis case report presents a rare case of an atypical head stab wound suffered by a drug addict and inflicted with a screwdriver during drug-induced psychosis. It describes the diagnostic and treatment procedures in the hospital and the findings of the subsequent autopsy. It also analyzes the review of the interpretation of the CT scans made upon admission and the subsequent treatment by an independent medical review panel, which revealed signs of medical mismanagement. Therefore, it also discusses the legal consequences that the case may have involved for the attending physicians in addition to the consequences for...
Source: Forensic Science, Medicine, and Pathology - March 27, 2024 Category: Forensic Medicine Source Type: research