The role of endothelin II type A receptor (ETAR) in transplant injury
Transpl Immunol. 2021 Nov 15;70:101505. doi: 10.1016/j.trim.2021.101505. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Antibody-mediated rejection is the leading cause of deterioration of graft function and graft loss after kidney transplantation. Recent studies have reported an increasing role of non-HLA antibodies in the humoral injury after kidney transplantation. We decided to present the influence of non-HLA antibodies - anti-endothelin II type A receptor (ETAR) on a transplanted kidney and characterize the significance of their receptor.RECENT FINDINGS: The role of non-HLA antibodies is still uncertain. Many studi...
Source: Transplant Immunology - November 18, 2021 Category: Transplant Surgery Authors: Katarzyna Nowa ńska Krzysztof Wi śnicki Magdalena Kuriata-Kordek Magdalena Krajewska Miros ław Banasik Source Type: research

The role of endothelin II type A receptor (ETAR) in transplant injury
Transpl Immunol. 2021 Nov 15;70:101505. doi: 10.1016/j.trim.2021.101505. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Antibody-mediated rejection is the leading cause of deterioration of graft function and graft loss after kidney transplantation. Recent studies have reported an increasing role of non-HLA antibodies in the humoral injury after kidney transplantation. We decided to present the influence of non-HLA antibodies - anti-endothelin II type A receptor (ETAR) on a transplanted kidney and characterize the significance of their receptor.RECENT FINDINGS: The role of non-HLA antibodies is still uncertain. Many studi...
Source: Transplant Immunology - November 18, 2021 Category: Transplant Surgery Authors: Katarzyna Nowa ńska Krzysztof Wi śnicki Magdalena Kuriata-Kordek Magdalena Krajewska Miros ław Banasik Source Type: research

The role of endothelin II type A receptor (ETAR) in transplant injury
Transpl Immunol. 2021 Nov 15:101505. doi: 10.1016/j.trim.2021.101505. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Antibody-mediated rejection is the leading cause of deterioration of graft function and graft loss after kidney transplantation. Recent studies have reported an increasing role of non-HLA antibodies in the humoral injury after kidney transplantation. We decided to present the influence of non-HLA antibodies - anti-endothelin II type A receptor (ETAR) on a transplanted kidney and characterize the significance of their receptor.RECENT FINDINGS: The role of non-HLA antibodies is still uncertain. Many studies ...
Source: Transplant Immunology - November 18, 2021 Category: Transplant Surgery Authors: Katarzyna Nowa ńska Krzysztof Grubizna Magdalena Kuriata-Kordek Magdalena Krajewska Miros ław Banasik Source Type: research

The role of endothelin II type A receptor (ETAR) in transplant injury
Transpl Immunol. 2021 Nov 15:101505. doi: 10.1016/j.trim.2021.101505. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Antibody-mediated rejection is the leading cause of deterioration of graft function and graft loss after kidney transplantation. Recent studies have reported an increasing role of non-HLA antibodies in the humoral injury after kidney transplantation. We decided to present the influence of non-HLA antibodies - anti-endothelin II type A receptor (ETAR) on a transplanted kidney and characterize the significance of their receptor.RECENT FINDINGS: The role of non-HLA antibodies is still uncertain. Many studies ...
Source: Transplant Immunology - November 18, 2021 Category: Transplant Surgery Authors: Katarzyna Nowa ńska Krzysztof Grubizna Magdalena Kuriata-Kordek Magdalena Krajewska Miros ław Banasik Source Type: research

The role of endothelin II type A receptor (ETAR) in transplant injury
Transpl Immunol. 2021 Nov 15:101505. doi: 10.1016/j.trim.2021.101505. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Antibody-mediated rejection is the leading cause of deterioration of graft function and graft loss after kidney transplantation. Recent studies have reported an increasing role of non-HLA antibodies in the humoral injury after kidney transplantation. We decided to present the influence of non-HLA antibodies - anti-endothelin II type A receptor (ETAR) on a transplanted kidney and characterize the significance of their receptor.RECENT FINDINGS: The role of non-HLA antibodies is still uncertain. Many studies ...
Source: Transplant Immunology - November 18, 2021 Category: Transplant Surgery Authors: Katarzyna Nowa ńska Krzysztof Grubizna Magdalena Kuriata-Kordek Magdalena Krajewska Miros ław Banasik Source Type: research

A study of the mechanisms responsible for the action of new immunosuppressants and their effects on rat small intestinal transplantation
In this report, we summarize our previous studies not only regarding the above drugs, but on an anti-complement drug and a JAK inhibitor as well.PMID:34785307 | DOI:10.1016/j.trim.2021.101497 (Source: Transplant Immunology)
Source: Transplant Immunology - November 17, 2021 Category: Transplant Surgery Authors: Shuji Miyagawa Tasuku Kodama Rei Matsuura Pei-Chi Lo Rieko Sakai Chiyoshi Toyama Yuichi Takama Yoshiyuki Ihara Yoichi Kakuta Kazuaki Yamanaka Katsuyoshi Matsunami Hiroshi Eguchi Akira Maeda Hiroomi Okuyama Source Type: research

A study of the mechanisms responsible for the action of new immunosuppressants and their effects on rat small intestinal transplantation
In this report, we summarize our previous studies not only regarding the above drugs, but on an anti-complement drug and a JAK inhibitor as well.PMID:34785307 | DOI:10.1016/j.trim.2021.101497 (Source: Transplant Immunology)
Source: Transplant Immunology - November 17, 2021 Category: Transplant Surgery Authors: Shuji Miyagawa Tasuku Kodama Rei Matsuura Pei-Chi Lo Rieko Sakai Chiyoshi Toyama Yuichi Takama Yoshiyuki Ihara Yoichi Kakuta Kazuaki Yamanaka Katsuyoshi Matsunami Hiroshi Eguchi Akira Maeda Hiroomi Okuyama Source Type: research

A study of the mechanisms responsible for the action of new immunosuppressants and their effects on rat small intestinal transplantation
In this report, we summarize our previous studies not only regarding the above drugs, but on an anti-complement drug and a JAK inhibitor as well.PMID:34785307 | DOI:10.1016/j.trim.2021.101497 (Source: Transplant Immunology)
Source: Transplant Immunology - November 17, 2021 Category: Transplant Surgery Authors: Shuji Miyagawa Tasuku Kodama Rei Matsuura Pei-Chi Lo Rieko Sakai Chiyoshi Toyama Yuichi Takama Yoshiyuki Ihara Yoichi Kakuta Kazuaki Yamanaka Katsuyoshi Matsunami Hiroshi Eguchi Akira Maeda Hiroomi Okuyama Source Type: research

T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses
Transpl Immunol. 2021 Nov 10;70:101495. doi: 10.1016/j.trim.2021.101495. Online ahead of print.ABSTRACTCytokines produced by T helper cells (Th cells) have essential roles in the body's defense against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward intracellular pathogens while T helper type 2 (Th2) cells are considered to be critical for the helminthic parasites' elimination swine-origin influenza A (H1N1) virus, a disease led to an epidemic in 2009 and rapidly spread globally via human-to-human transmission. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndro...
Source: Transplant Immunology - November 14, 2021 Category: Transplant Surgery Authors: Elahe Aleebrahim-Dehkordi Bahareh Molavi Melika Mokhtari Niloofar Deravi Mobina Fathi Tara Fazel Mehdi Mohebalizadeh Pooneh Koochaki Parnian Shobeiri Ali Hasanpour-Dehkordi Source Type: research

Urinary CXCL10 specifically relates to HLA-DQ eplet mismatch load in kidney transplant recipients
CONCLUSIONS: uCXCL10 specifically relates to HLA-DQ eplet mismatch load. This relationship can partly explain the previously reported association between uCXCL10 excretion and graft inflammation. An adequate evaluation of any potential non-invasive biomarker, such as uCXCL10, must take into account the HLA molecular mismatch.PMID:34774739 | DOI:10.1016/j.trim.2021.101494 (Source: Transplant Immunology)
Source: Transplant Immunology - November 14, 2021 Category: Transplant Surgery Authors: David San Segundo Sandra A Guiral-Foz Adalberto Benito-Hern ández Andr é Renaldo Fernández Alvaro Arnau Rosal ía Valero Mar ía Angeles Ramos-Barrón Mar ía Teresa García-Unzueta Jos é María Gómez-Ortega Marcos L ópez-Hoyos Juan Carlos Ruiz Emil Source Type: research

MiR-702-3p inhibits the inflammatory injury in septic H9c2 cells by regulating NOD1
CONCLUSION: MiR-702-3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR-702-3p may be a potential new target for the treatment of SIC.PMID:34774740 | DOI:10.1016/j.trim.2021.101493 (Source: Transplant Immunology)
Source: Transplant Immunology - November 14, 2021 Category: Transplant Surgery Authors: Chun Liu Yang Yang Guiwen Liang Aixian Zhang Feng Xu Source Type: research

T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses
Transpl Immunol. 2021 Nov 10:101495. doi: 10.1016/j.trim.2021.101495. Online ahead of print.ABSTRACTCytokines produced by T helper cells (Th cells) have essential roles in the body's defense against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward intracellular pathogens while T helper type 2 (Th2) cells are considered to be critical for the helminthic parasites' elimination swine-origin influenza A (H1N1) virus, a disease led to an epidemic in 2009 and rapidly spread globally via human-to-human transmission. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome ...
Source: Transplant Immunology - November 14, 2021 Category: Transplant Surgery Authors: Elahe Aleebrahim-Dehkordi Bahareh Molavi Melika Mokhtari Niloofar Deravi Mobina Fathi Tara Fazel Mehdi Mohebalizadeh Pooneh Koochaki Parnian Shobeiri Ali Hasanpour-Dehkordi Source Type: research

Urinary CXCL10 specifically relates to HLA-DQ eplet mismatch load in kidney transplant recipients
CONCLUSIONS: uCXCL10 specifically relates to HLA-DQ eplet mismatch load. This relationship can partly explain the previously reported association between uCXCL10 excretion and graft inflammation. An adequate evaluation of any potential non-invasive biomarker, such as uCXCL10, must take into account the HLA molecular mismatch.PMID:34774739 | DOI:10.1016/j.trim.2021.101494 (Source: Transplant Immunology)
Source: Transplant Immunology - November 14, 2021 Category: Transplant Surgery Authors: David San Segundo Sandra A Guiral-Foz Adalberto Benito-Hern ández Andr é Renaldo Fernández Alvaro Arnau Rosal ía Valero Mar ía Angeles Ramos-Barrón Mar ía Teresa García-Unzueta Jos é María Gómez-Ortega Marcos L ópez-Hoyos Juan Carlos Ruiz Emil Source Type: research

MiR-702-3p inhibits the inflammatory injury in septic H9c2 cells by regulating NOD1
CONCLUSION: MiR-702-3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR-702-3p may be a potential new target for the treatment of SIC.PMID:34774740 | DOI:10.1016/j.trim.2021.101493 (Source: Transplant Immunology)
Source: Transplant Immunology - November 14, 2021 Category: Transplant Surgery Authors: Chun Liu Yang Yang Guiwen Liang Aixian Zhang Feng Xu Source Type: research

Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients
In conclusion, we show that immunoglobulin and autoreactive antibody levels are not significantly different in COPD LTx recipients that develop PGD. However, using a novel IgG glycomic analysis we were able to demonstrate multiple significant increases in IgG1 specific N-glycan signatures that were predictive of PGD development. Taken together, these data represent a potential novel method for identifying COPD patients at risk for PGD development and may provide clues to mechanisms by which antibody N-glycan signatures could contribute to antibody-mediated PGD pathogenesis.PMID:34767945 | DOI:10.1016/j.trim.2021.101491 (So...
Source: Transplant Immunology - November 12, 2021 Category: Transplant Surgery Authors: Alexander McQuiston Danielle Scott Dianna Nord Logan Langerude Andres Pelaez Tiago Machuca Anand Mehta Jason D Chrisie Peggi Angel Carl Atkinson Source Type: research

Complete recovery of complicated methotrexate-induced liver cirrhosis in a patient with psoriasis: A case report
This study emphasizes the reversibility of MTX-induced liver cirrhosis: cirrhosis is not aggressive, can be reversible, and is dose- and duration-dependent.PMID:34767946 | DOI:10.1016/j.trim.2021.101492 (Source: Transplant Immunology)
Source: Transplant Immunology - November 12, 2021 Category: Transplant Surgery Authors: Said El Hage Dany Akiki Jad Masri Majd Roustom Source Type: research

Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients
In conclusion, we show that immunoglobulin and autoreactive antibody levels are not significantly different in COPD LTx recipients that develop PGD. However, using a novel IgG glycomic analysis we were able to demonstrate multiple significant increases in IgG1 specific N-glycan signatures that were predictive of PGD development. Taken together, these data represent a potential novel method for identifying COPD patients at risk for PGD development and may provide clues to mechanisms by which antibody N-glycan signatures could contribute to antibody-mediated PGD pathogenesis.PMID:34767945 | DOI:10.1016/j.trim.2021.101491 (So...
Source: Transplant Immunology - November 12, 2021 Category: Transplant Surgery Authors: Alexander McQuiston Danielle Scott Dianna Nord Logan Langerude Andres Pelaez Tiago Machuca Anand Mehta Jason D Chrisie Peggi Angel Carl Atkinson Source Type: research

Complete recovery of complicated methotrexate-induced liver cirrhosis in a patient with psoriasis: A case report
This study emphasizes the reversibility of MTX-induced liver cirrhosis: cirrhosis is not aggressive, can be reversible, and is dose- and duration-dependent.PMID:34767946 | DOI:10.1016/j.trim.2021.101492 (Source: Transplant Immunology)
Source: Transplant Immunology - November 12, 2021 Category: Transplant Surgery Authors: Said El Hage Dany Akiki Jad Masri Majd Roustom Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22;69:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with three years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with 3 years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with 3 years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3  years: The road towards new recommendations
Transpl Immunol. 2021 Oct 22:101490. doi: 10.1016/j.trim.2021.101490. Online ahead of print.ABSTRACTBACKGROUND: Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).OBJECTIVE: This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.MATERIAL AND METHODS: Records of 80 adult kidney transplant patients were reviewed with 3 years of the follow-up. All patients had panel reactive antibodies (PRA)
Source: Transplant Immunology - October 25, 2021 Category: Transplant Surgery Authors: Maroun Abou-Jaoud é Said El Hage Dany Akiki Rita Araman Source Type: research

Perceived body image and distress after liver tansplantation in recipients
This study's aim was to determine the relationship between the perception of self-body image and the level of distress in patients who had liver transplantation surgery.METHOD: This study was performed as a descriptive and cross-sectional study with the attendance of 120 liver transplant patients hospitalized in the liver transplant center of a training and research hospital. Self-body image was measured based on the Body Image Questionnaire (BIQ) on a scale of 40 (lowest) to 200 (highest) with the optimal BIQ score of 135-200. The level of distress was evaluated by the Distress Thermometer (DT) on a scale of 0 (None) to 1...
Source: Transplant Immunology - October 24, 2021 Category: Transplant Surgery Authors: Bilsev Demirrn Semra Bulbuloglurn Source Type: research

Prospective multi-centric study to analyze pre-transplant compatibility algorithm for live-related donor kidney transplant in Indian setting: The "Delhi approach"!
CONCLUSIONS: Our results showed that the algorithm of FCXM with HAS produced the best sensitivity of 100%. The specificity of 76.1% indicate that the combined FCXM+HAS assays may detect up to 24.9% false positive results. We suggest that these false-positives may be easily resolved by performing the virtual crossmatch based on HAI (SAB) results. In our reflex testing algorithmic approach only 49% patients needed HAI (SAB). Finally, our results suggested that the CDCXM assay may be discontinued in pre-transplant workup owing to its very low sensitivity (12.1%).PMID:34688882 | DOI:10.1016/j.trim.2021.101487 (Source: Transplant Immunology)
Source: Transplant Immunology - October 24, 2021 Category: Transplant Surgery Authors: K Tiwari Aseem Handoo Anil Choudhary Mohit Mehra Simmi Bacchas Virender Yadav Ayushi Negi Avinash Chopra Ramona Source Type: research

Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors
This study aimed to compare preoperative chemoradiotherapy (CRT) with postoperative CRT regarding survival, local control, disease control, sphincter preservation, toxicity and also prognostic factors for the treatment of locally advanced rectal cancer.METHODS: Records of 140 patients with locally advanced rectal cancer who received preoperative or postoperative CRT were analyzed retrospectively. We compared the treatment groups (preoperative vs postoperative) according to baseline characteristics (demographic and rectal cancer disease characteristics), and also carried out the survival analyses.RESULTS: From January 2010 ...
Source: Transplant Immunology - October 23, 2021 Category: Transplant Surgery Authors: Mursel Duzova Hamit Basaran Gokcen Inan Osman Vefa Gul Orhan Onder Eren Muslu Kaz ım Korez Source Type: research

The effect of navigation programme on the management of symptoms related to head and neck radiotherapy
This study aims to determine the effect of navigation programme in the management of symptoms related to head and neck cancer (HNC) radiotherapy.METHODS: This randomized, controlled and experimental study was conducted between November 2018 and March 2020 with the participation of 88 patients with HNC receiving radiotherapy. Referring to the pre-prepared randomization checklist, 41 people were randomized to the experimental group and 47 to the control group. While the standard treatment approaches of the hospital were applied to all patients, the patients in the experimental group were applied an additional nursing navigat...
Source: Transplant Immunology - October 23, 2021 Category: Transplant Surgery Authors: Ulku Saygili Duzova Gulbeyaz Can Source Type: research

The impact of different doses of antithymocyte globulin conditioning on immune reconstitution upon hematopoietic stem cell transplantation
CONCLUSION: The ATG therapy at higher and lower doses led to a delayed reconstitution of T cells and the inversion of CD4/CD8 ratio for at least one year after HSCT.PMID:34678462 | DOI:10.1016/j.trim.2021.101486 (Source: Transplant Immunology)
Source: Transplant Immunology - October 22, 2021 Category: Transplant Surgery Authors: Yahan Li Mingyang Wang Xiaosheng Fang Yujie Jiang Xiaohui Sui Ying Li Xin Liu Xianghua Wang Dongyue Lu Xue Sun Hongzhi Xu Xin Wang Source Type: research

Hyperacute rejection in ABO-incompatible kidney transplantation: Significance of isoagglutinin subclass
DISCUSSION: Hyperacute rejection resulting from increased IgG1 isoagglutinin subclass has not been previously confirmed using flow cytometry. Unfortunate outcome of this rejection case provides insight to how we should approach and ensure successful ABO-incompatible kidney transplantation.PMID:34678463 | DOI:10.1016/j.trim.2021.101484 (Source: Transplant Immunology)
Source: Transplant Immunology - October 22, 2021 Category: Transplant Surgery Authors: John Jeongseok Yang Chung Hee Baek Hyosang Kim Hyunwook Kwon Sung Shin Young Hoon Kim Sang-Hyun Hwang Heung-Bum Oh Su-Kil Park Duck Cho Dae-Hyun Ko Source Type: research

Evaluation of rejection, infection, and malignancy outcomes in elderly liver transplant recipients receiving a similar level of immunosuppression compared to a younger group
Transpl Immunol. 2021 Oct 18;69:101485. doi: 10.1016/j.trim.2021.101485. Online ahead of print.ABSTRACTElderly liver transplant (LTx) recipients at a lower risk of acute rejection compared to younger recipients due to immunosenescence. As such, they may benefit from reduced immunosuppression (IS) to minimize infectious and malignant complications. We aimed to evaluate outcomes in LTx recipients ≥60 years compared to a younger group of LTx recipients aged 18-59 years maintained on a similar level of IS. This was a single-center retrospective evaluation of adult LTx recipients from 2013 to 2018 who received methylpredniso...
Source: Transplant Immunology - October 21, 2021 Category: Transplant Surgery Authors: Bassem Almalki Clare Kane Kathleen Cunningham Carly D'Agostino Antonia Novak Michelle Kapugi Daniela Ladner Jamie Schulte Source Type: research

Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?
Transpl Immunol. 2021 Oct 14;69:101482. doi: 10.1016/j.trim.2021.101482. Online ahead of print.ABSTRACTCell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODE...
Source: Transplant Immunology - October 17, 2021 Category: Transplant Surgery Authors: Mepur H Ravindranath Edward J Filippone Carly J Amato-Menker Fernando A Arosa Ballabh Das Yijun Ou Allen J Norin Source Type: research

Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?
Transpl Immunol. 2021 Oct 14;69:101482. doi: 10.1016/j.trim.2021.101482. Online ahead of print.ABSTRACTCell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODE...
Source: Transplant Immunology - October 17, 2021 Category: Transplant Surgery Authors: Mepur H Ravindranath Edward J Filippone Carly J Amato-Menker Fernando A Arosa Ballabh Das Yijun Ou Allen J Norin Source Type: research

Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?
Transpl Immunol. 2021 Oct 14;69:101482. doi: 10.1016/j.trim.2021.101482. Online ahead of print.ABSTRACTCell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODE...
Source: Transplant Immunology - October 17, 2021 Category: Transplant Surgery Authors: Mepur H Ravindranath Edward J Filippone Carly J Amato-Menker Fernando A Arosa Ballabh Das Yijun Ou Allen J Norin Source Type: research

Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?
Transpl Immunol. 2021 Oct 14:101482. doi: 10.1016/j.trim.2021.101482. Online ahead of print.ABSTRACTCell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODES S...
Source: Transplant Immunology - October 17, 2021 Category: Transplant Surgery Authors: Mepur H Ravindranath Edward J Filippone Carly J Amato-Menker Fernando A Arosa Ballabh Das Yijun Ou Allen J Norin Source Type: research

Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?
Transpl Immunol. 2021 Oct 14:101482. doi: 10.1016/j.trim.2021.101482. Online ahead of print.ABSTRACTCell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODES S...
Source: Transplant Immunology - October 17, 2021 Category: Transplant Surgery Authors: Mepur H Ravindranath Edward J Filippone Carly J Amato-Menker Fernando A Arosa Ballabh Das Yijun Ou Allen J Norin Source Type: research

Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?
Transpl Immunol. 2021 Oct 14:101482. doi: 10.1016/j.trim.2021.101482. Online ahead of print.ABSTRACTCell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODES S...
Source: Transplant Immunology - October 17, 2021 Category: Transplant Surgery Authors: Mepur H Ravindranath Edward J Filippone Carly J Amato-Menker Fernando A Arosa Ballabh Das Yijun Ou Allen J Norin Source Type: research

Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?
Transpl Immunol. 2021 Oct 14:101482. doi: 10.1016/j.trim.2021.101482. Online ahead of print.ABSTRACTCell surface HLA class I consists of trimers, i.e., alpha - heavy chain, beta - 2 - microglobulin, and a peptide, termed closed conformers (CC) on non-activated lymphocytes. HLA class I and class II may also exist, respectively, as alpha-chain only or alpha and beta - chain only on activated cells termed open conformers (OC). We extend previous studies using an OC-specific monoclonal antibody that demonstrate LABScreen HLA class I and II single antigen beads (SABs) contain a mixture of open and closed conformers. LIFECODES S...
Source: Transplant Immunology - October 17, 2021 Category: Transplant Surgery Authors: Mepur H Ravindranath Edward J Filippone Carly J Amato-Menker Fernando A Arosa Ballabh Das Yijun Ou Allen J Norin Source Type: research

Fear of COVID 19 and social effects in liver transplant patients
CONCLUSION: The results show that it is important for transplant centers to be able to provide guidance and psychological counseling services to liver transplant patients, who are significantly affected by COVID 19, through telemedicine or various technological opportunities.PMID:34626805 | PMC:PMC8494991 | DOI:10.1016/j.trim.2021.101479 (Source: Transplant Immunology)
Source: Transplant Immunology - October 9, 2021 Category: Transplant Surgery Authors: Runida Do ğan Emine Kaplan Serin Nazl ıcan Bağci Source Type: research

Fear of COVID 19 and social effects in liver transplant patients
CONCLUSION: The results show that it is important for transplant centers to be able to provide guidance and psychological counseling services to liver transplant patients, who are significantly affected by COVID 19, through telemedicine or various technological opportunities.PMID:34626805 | PMC:PMC8494991 | DOI:10.1016/j.trim.2021.101479 (Source: Transplant Immunology)
Source: Transplant Immunology - October 9, 2021 Category: Transplant Surgery Authors: Runida Do ğan Emine Kaplan Serin Nazl ıcan Bağci Source Type: research

Fear of COVID 19 and social effects in liver transplant patients
CONCLUSION: The results show that it is important for transplant centers to be able to provide guidance and psychological counseling services to liver transplant patients, who are significantly affected by COVID 19, through telemedicine or various technological opportunities.PMID:34626805 | PMC:PMC8494991 | DOI:10.1016/j.trim.2021.101479 (Source: Transplant Immunology)
Source: Transplant Immunology - October 9, 2021 Category: Transplant Surgery Authors: Runida Do ğan Emine Kaplan Serin Nazl ıcan Bağci Source Type: research

Fear of COVID 19 and social effects in liver transplant patients
CONCLUSION: The results show that it is important for transplant centers to be able to provide guidance and psychological counseling services to liver transplant patients, who are significantly affected by COVID 19, through telemedicine or various technological opportunities.PMID:34626805 | PMC:PMC8494991 | DOI:10.1016/j.trim.2021.101479 (Source: Transplant Immunology)
Source: Transplant Immunology - October 9, 2021 Category: Transplant Surgery Authors: Runida Do ğan Emine Kaplan Serin Nazl ıcan Bağci Source Type: research