Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study
CONCLUSION: PTDM in transplant patients had milder microvascular complications than usually expected in Type 1/2 diabetes in non-transplant patients. DR was not strongly associated with DKD in PTDM patients. Furthermore, de-novo DKD development was associated with poor glycaemic control and increased proteinuria.PMID:38403198 | DOI:10.1016/j.trim.2024.102012 (Source: Transplant Immunology)
Source: Transplant Immunology - February 25, 2024 Category: Transplant Surgery Authors: None Abdullah Indrajeet Momin Anupma Kaul Dharmendra Bhadauria Narayan Prasad Manas Behera Manas Patel Ravi Kushwaha Monika Yachha Aneesh Srivastava Source Type: research

Role of HLA matching and donor specific antibody development in long-term survival, acute rejection and cardiac allograft vasculopathy
In this study it is analyzed retrospectively the influence of HLA matching and anti-HLA antibodies on overall survival, AMR and CAV in heart transplantation. For this retrospective study are recruited heart transplanted patients at the Cardiac Transplantation Centre of Naples between 2000 and 2019. Among the 155 heart transplant patients, the mean number of HLA-A, B, -DR MM (0 to 6) between donor and recipient was 4.5 ± 1.1. The results show a negative association between MM HLA-DR and survival (p = 0.01). Comparison of patients with 0-1 MM at each locus to all others with 2 MM, for both HLA class I and class II, has not ...
Source: Transplant Immunology - February 25, 2024 Category: Transplant Surgery Authors: Dario Costa Antonietta Picascia Vincenzo Grimaldi Cristiano Amarelli Andrea Petraio Anna Levi Mario Di Donato Anna Virginia Adriana Pirozzi Carmela Fiorito Giusi Moccia Aurora Gallo Mariagrazia Strozziero Claudio Marra Marisa De Feo Francesco Cacciatore C Source Type: research

Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study
CONCLUSION: PTDM in transplant patients had milder microvascular complications than usually expected in Type 1/2 diabetes in non-transplant patients. DR was not strongly associated with DKD in PTDM patients. Furthermore, de-novo DKD development was associated with poor glycaemic control and increased proteinuria.PMID:38403198 | DOI:10.1016/j.trim.2024.102012 (Source: Transplant Immunology)
Source: Transplant Immunology - February 25, 2024 Category: Transplant Surgery Authors: None Abdullah Indrajeet Momin Anupma Kaul Dharmendra Bhadauria Narayan Prasad Manas Behera Manas Patel Ravi Kushwaha Monika Yachha Aneesh Srivastava Source Type: research

Role of HLA matching and donor specific antibody development in long-term survival, acute rejection and cardiac allograft vasculopathy
In this study it is analyzed retrospectively the influence of HLA matching and anti-HLA antibodies on overall survival, AMR and CAV in heart transplantation. For this retrospective study are recruited heart transplanted patients at the Cardiac Transplantation Centre of Naples between 2000 and 2019. Among the 155 heart transplant patients, the mean number of HLA-A, B, -DR MM (0 to 6) between donor and recipient was 4.5 ± 1.1. The results show a negative association between MM HLA-DR and survival (p = 0.01). Comparison of patients with 0-1 MM at each locus to all others with 2 MM, for both HLA class I and class II, has not ...
Source: Transplant Immunology - February 25, 2024 Category: Transplant Surgery Authors: Dario Costa Antonietta Picascia Vincenzo Grimaldi Cristiano Amarelli Andrea Petraio Anna Levi Mario Di Donato Anna Virginia Adriana Pirozzi Carmela Fiorito Giusi Moccia Aurora Gallo Mariagrazia Strozziero Claudio Marra Marisa De Feo Francesco Cacciatore C Source Type: research

Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study
CONCLUSION: PTDM in transplant patients had milder microvascular complications than usually expected in Type 1/2 diabetes in non-transplant patients. DR was not strongly associated with DKD in PTDM patients. Furthermore, de-novo DKD development was associated with poor glycaemic control and increased proteinuria.PMID:38403198 | DOI:10.1016/j.trim.2024.102012 (Source: Transplant Immunology)
Source: Transplant Immunology - February 25, 2024 Category: Transplant Surgery Authors: None Abdullah Indrajeet Momin Anupma Kaul Dharmendra Bhaduaria Narayan Prasad Manas Behera Manas Patel Ravi Kushwaha Monika Yachha Aneesh Srivastava Source Type: research

Role of HLA matching and donor specific antibody development in long-term survival, acute rejection and cardiac allograft vasculopathy
In this study it is analyzed retrospectively the influence of HLA matching and anti-HLA antibodies on overall survival, AMR and CAV in heart transplantation. For this retrospective study are recruited heart transplanted patients at the Cardiac Transplantation Centre of Naples between 2000 and 2019. Among the 155 heart transplant patients, the mean number of HLA-A, B, -DR MM (0 to 6) between donor and recipient was 4.5 ± 1.1. The results show a negative association between MM HLA-DR and survival (p = 0.01). Comparison of patients with 0-1 MM at each locus to all others with 2 MM, for both HLA class I and class II, has not ...
Source: Transplant Immunology - February 25, 2024 Category: Transplant Surgery Authors: Dario Costa Antonietta Picascia Vincenzo Grimaldi Cristiano Amarelli Andrea Petraio Anna Levi Mario Di Donato Anna Virginia Adriana Pirozzi Carmela Fiorito Giusi Moccia Aurora Gallo Mariagrazia Strozziero Claudio Marra Marisa De Feo Francesco Cacciatore C Source Type: research

Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study
CONCLUSION: PTDM in transplant patients had milder microvascular complications than usually expected in Type 1/2 diabetes in non-transplant patients. DR was not strongly associated with DKD in PTDM patients. Furthermore, de-novo DKD development was associated with poor glycaemic control and increased proteinuria.PMID:38403198 | DOI:10.1016/j.trim.2024.102012 (Source: Transplant Immunology)
Source: Transplant Immunology - February 25, 2024 Category: Transplant Surgery Authors: None Abdullah Indrajeet Momin Anupma Kaul Dharmendra Bhaduaria Narayan Prasad Manas Behera Manas Patel Ravi Kushwaha Monika Yachha Aneesh Srivastava Source Type: research

Long-term remission of infantile Takayasu arteritis associated with germline CBL syndrome after allogeneic hematopoietic stem cell transplantation: A case report and literature review
We report a female patient with growth delay, developmental issues, and congenital heart disease who was admitted at 14 months of age with massive splenomegaly, lymphadenopathy, fever, and hypertension. Body imaging studies revealed arterial stenosis and wall inflammation of the aorta and multiple thoracic and abdominal branches. Whole exome sequencing revealed a pathogenic variant in CBL with loss of heterozygosity in blood cells, diagnosing CBL syndrome, complicated by JMML and TA. Allogeneic HSCT induced remission of JMML and TA, permitting discontinuation of immunosuppression after 12 months. Six years later, her TA is...
Source: Transplant Immunology - February 23, 2024 Category: Transplant Surgery Authors: Elizabeth Munoz-Osores Mervin Pi ñones Francisco Barriga Mar ía Angélica Wietstruck Guillermo P érez-Mateluna Cecilia Mellado Mariana Aracena Rodrigo Parra Cristi án García Arturo Borzutzky Source Type: research

Conversion from twice-daily everolimus to once-daily sirolimus in long-term stable liver transplant recipients
CONCLUSION: The results of our study indicate that conversion from once-daily EVR to once-daily SIR in stable LT patients is safe, but needs dose adaptations and careful monitoring.PMID:38395088 | DOI:10.1016/j.trim.2024.102014 (Source: Transplant Immunology)
Source: Transplant Immunology - February 23, 2024 Category: Transplant Surgery Authors: J érôme Dumortier Olivier Boillot Source Type: research

Long-term remission of infantile Takayasu arteritis associated with germline CBL syndrome after allogeneic hematopoietic stem cell transplantation: A case report and literature review
We report a female patient with growth delay, developmental issues, and congenital heart disease who was admitted at 14 months of age with massive splenomegaly, lymphadenopathy, fever, and hypertension. Body imaging studies revealed arterial stenosis and wall inflammation of the aorta and multiple thoracic and abdominal branches. Whole exome sequencing revealed a pathogenic variant in CBL with loss of heterozygosity in blood cells, diagnosing CBL syndrome, complicated by JMML and TA. Allogeneic HSCT induced remission of JMML and TA, permitting discontinuation of immunosuppression after 12 months. Six years later, her TA is...
Source: Transplant Immunology - February 23, 2024 Category: Transplant Surgery Authors: Elizabeth Munoz-Osores M Mervin Pi ñones Francisco Barriga Mar ía Angélica Wietstruck Guillermo P érez-Mateluna Cecilia Mellado Mariana Aracena Rodrigo Parra Cristi án García Arturo Borzutzky Source Type: research

Conversion from twice-daily everolimus to once-daily sirolimus in long-term stable liver transplant recipients
CONCLUSION: The results of our study indicate that conversion from once-daily EVR to once-daily SIR in stable LT patients is safe, but needs dose adaptations and careful monitoring.PMID:38395088 | DOI:10.1016/j.trim.2024.102014 (Source: Transplant Immunology)
Source: Transplant Immunology - February 23, 2024 Category: Transplant Surgery Authors: J érôme Dumortier Olivier Boillot Source Type: research

Retrospective analysis on incidence and risk factors of post-transplant diabetes mellitus after lung transplantation and its association with clinical outcomes
CONCLUSION: Advanced age, elevated HbA1c levels, KCNJ11 gene polymorphism, and early exposure to tacrolimus are all significant risk factors for PTDM following LTx. The clinical implications of these factors warrant attention.PMID:38342328 | DOI:10.1016/j.trim.2024.102008 (Source: Transplant Immunology)
Source: Transplant Immunology - February 11, 2024 Category: Transplant Surgery Authors: Wenwen Du Xiaoxing Wang Dan Zhang Xianbo Zuo Source Type: research

H < sub > 2 < /sub > S alleviates renal ischemia and reperfusion injury by suppressing ERS-induced autophagy
CONCLUSIONS: Our results suggest that the CSE/H2S system is an important therapeutic target for protecting against renal IRI, and it may protect renal tubule epithelial cells from IRI by suppressing ERS-induced autophagy.PMID:38342329 | DOI:10.1016/j.trim.2024.102006 (Source: Transplant Immunology)
Source: Transplant Immunology - February 11, 2024 Category: Transplant Surgery Authors: Sujuan Feng Jiawei Ji Han Li Xiaodong Zhang Source Type: research

Retrospective analysis on incidence and risk factors of post-transplant diabetes mellitus after lung transplantation and its association with clinical outcomes
CONCLUSION: Advanced age, elevated HbA1c levels, KCNJ11 gene polymorphism, and early exposure to tacrolimus are all significant risk factors for PTDM following LTx. The clinical implications of these factors warrant attention.PMID:38342328 | DOI:10.1016/j.trim.2024.102008 (Source: Transplant Immunology)
Source: Transplant Immunology - February 11, 2024 Category: Transplant Surgery Authors: Wenwen Du Xiaoxing Wang Dan Zhang Xianbo Zuo Source Type: research

H < sub > 2 < /sub > S alleviates renal ischemia and reperfusion injury by suppressing ERS-induced autophagy
CONCLUSIONS: Our results suggest that the CSE/H2S system is an important therapeutic target for protecting against renal IRI, and it may protect renal tubule epithelial cells from IRI by suppressing ERS-induced autophagy.PMID:38342329 | DOI:10.1016/j.trim.2024.102006 (Source: Transplant Immunology)
Source: Transplant Immunology - February 11, 2024 Category: Transplant Surgery Authors: Sujuan Feng Jiawei Ji Han Li Xiaodong Zhang Source Type: research