Tacrolimus impairs airway mucociliary clearance of rats
CONCLUSIONS: TAC impairs airway mucociliary clearance of rats.PMID:38199268 | DOI:10.1016/j.trim.2024.101990 (Source: Transplant Immunology)
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: Maristela Prado E Silva S ônia de Fátima Soto Francine Maria de Almeida Aristides Tadeu Correia Paulo Manuel P êgo-Fernandes Rogerio Pazetti Source Type: research
Investigating the effect of pre-transplant thrombocytopenia and anemia on the engraftment and long-term survival in multiple myeloma patients
CONCLUSION: Thrombocytopenia and anemia before transplantation are related to slower Plt/WBC engraftment and as prognostic factors might predict the long-term survival of MM patients following ASCT.PMID:38199269 | DOI:10.1016/j.trim.2024.101991 (Source: Transplant Immunology)
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: Dariush Kadkhoda Maryam Nikoonezhad Hossein Bonakchi Mahshid Mehdizadeh Abbas Hajifathali Ahmad Reza Baghestani Leila Jabarinanva Ali Akbar Khadem Maboudi Source Type: research
Allogeneic hematopoietic stem cell transplantation: A single-center experience, 2017 to 2021
CONCLUSION: Donor type and donor age significantly impacted HSCT outcomes in our analysis, thus emphasizing the importance of rigorous donor selection in risk stratification and suggesting potential benefits for younger donors.PMID:38199270 | DOI:10.1016/j.trim.2024.101989 (Source: Transplant Immunology)
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: Patr ícia Cristina Lopes da Silva Guilherme Campos Muzzi Maressa Ribeiro Vilela Raquel A Fabreti-Oliveira Source Type: research
Conversion from calcineurin inhibitors to belatacept-based immunosuppressive therapy skews terminal proliferation of non-classical monocytes and lowers lymphocyte counts
Transpl Immunol. 2024 Feb;82:101976. doi: 10.1016/j.trim.2023.101976. Epub 2024 Jan 8.ABSTRACTBelatacept, a modified form of CTLA-Ig that blocks CD28-mediated co-stimulation of T cells, is an immune-suppressant that can be used as an alternative to calcineurin inhibitors (CNIs). In kidney transplant recipients, belatacept has been associated with improved renal function and reduced cardiovascular toxicity. Monocytes as well as T-lymphocytes play causal roles in the pathophysiology of atherosclerotic disease. We hypothesized that the beneficial impact of the use of belatacept over CNIs on cardiovascular risk could be partly...
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: O W Bredewold A M van Oeveren-Rietdijk B Florijn J I Rotmans J W de Fijter C van Kooten A J van Zonneveld H C de Boer Source Type: research
Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning
CONCLUSION: MMUD with better GVHD prophylaxis might be preferred over CB in patients with older age and comorbidities.PMID:38185390 | DOI:10.1016/j.trim.2024.101988 (Source: Transplant Immunology)
Source: Transplant Immunology - January 7, 2024 Category: Transplant Surgery Authors: Masatomo Kuno Hideo Koh Kentaro Ido Kazuki Sakatoku Yosuke Makuuchi Teruhito Takakuwa Asao Hirose Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Mika Nakamae Masayuki Hino Hirohisa Nakamae Source Type: research
Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning
CONCLUSION: MMUD with better GVHD prophylaxis might be preferred over CB in patients with older age and comorbidities.PMID:38185390 | DOI:10.1016/j.trim.2024.101988 (Source: Transplant Immunology)
Source: Transplant Immunology - January 7, 2024 Category: Transplant Surgery Authors: Masatomo Kuno Hideo Koh Kentaro Ido Kazuki Sakatoku Yosuke Makuuchi Teruhito Takakuwa Asao Hirose Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Mika Nakamae Masayuki Hino Hirohisa Nakamae Source Type: research
Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning
CONCLUSION: MMUD with better GVHD prophylaxis might be preferred over CB in patients with older age and comorbidities.PMID:38185390 | DOI:10.1016/j.trim.2024.101988 (Source: Transplant Immunology)
Source: Transplant Immunology - January 7, 2024 Category: Transplant Surgery Authors: Masatomo Kuno Hideo Koh Kentaro Ido Kazuki Sakatoku Yosuke Makuuchi Teruhito Takakuwa Asao Hirose Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Mika Nakamae Masayuki Hino Hirohisa Nakamae Source Type: research
The association between activation of the ERK1/2-NF- κB signaling pathway by TIMP2 expression and chronic renal allograft dysfunction in the CRAD rat model
CONCLUSION: A decrease of TIMP2 can alleviate the progression of inflammation in CRAD via inhibition of the ERK1/2-NF-κB signaling pathway.PMID:38184210 | DOI:10.1016/j.trim.2023.101984 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Tong Chen Shiquan Wu Ling Feng Siyu Long Yu Liu Caibin Zhang Wenqian Lu Yuli Shen Shanshan Jiang Wenya Chen Guoai Hong Li Zhou Fang Wang Yuechan Luo Hequn Zou Source Type: research
Recruiting refugees and migrants as potential hematopoietic stem cell donors to serve patients of comparable ethnicities with rare human leucocyte antigen patterns - The BluStar.NRW project in North Western Germany
Transpl Immunol. 2024 Jan 4:101985. doi: 10.1016/j.trim.2024.101985. Online ahead of print.ABSTRACTCurrently, approximately 19 million people with a migration background live in Germany. The majority of those descend from regions where the population has a genetically different distribution of HLA antigens when compared to the HLA frequencies usually found in North Western Europe. In case of severe haematological disorders of these individuals, allogeneic stem cell transplantation may be the treatment of choice. However, finding appropriate histocompatible hematopoietic stem cell donors continues to be a major challenge. I...
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: F M Heinemann C Baumgart C Binder V B örger J Fischer A Heinold C Jim énez Klingberg V Lenz S Riebschl äger T Zeiler P A Horn L Kordelas Source Type: research
Neutrophil: Lymphocyte and platelet: Lymphocyte ratios measured before transplantation and their correlation with new-onset diabetes post-transplantation in renal transplant recipients
CONCLUSION: NLR and PLR measured before transplantation were good predictors for NODAT in the first 2 years post-renal transplantation.PMID:38184212 | DOI:10.1016/j.trim.2023.101979 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Nguyen Thi Thuy Dung Pham Vu Thuy Nguyen Tr í Tue Truong Quy Kien Nguyen Van Duc Diem Thi Van Do Manh Ha Nguyen Thi Thu Ha Phan Ba Nghia Nguyen Trung Kien Tran Van Hinh Nguyen Minh Nui Pham Quoc Toan Nguyen Duc Loc Dang Thi Viet Ha Do Gia Tuyen Le Viet T Source Type: research
Caffeine and naloxone treated mesenchymal stem cells improve symptoms and reduce inflammation in a mouse model of ulcerative colitis
CONCLUSION: MSCs treated with caffeine and naloxone can enhance the immunoregulatory potential of these. As a result, treated MSCs can lead to improved clinical signs and reduced inflammatory parameters in mice with UC, making this approach a useful way for controlling and treating the disease. However, additional research is needed to access the mechanism behind the stronger immune system regulatory effects of treated MSCs in UC treatment.PMID:38184213 | DOI:10.1016/j.trim.2024.101986 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Milad Beygi Jalal Shayegh Hadi Esmaeili Gouvarchin Ghaleh Source Type: research
Effect of GVHD on the gut and intestinal microflora
Transpl Immunol. 2024 Jan 4:101977. doi: 10.1016/j.trim.2023.101977. Online ahead of print.ABSTRACTGraft-versus-host disease (GVHD) is one of the most important cause of death in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The gastrointestinal tract is one of the most common sites affected by GVHD. However, there is no gold standard clinical practice for diagnosing gastrointestinal GVHD (GI-GVHD), and it is mainly diagnosed by the patient's clinical symptoms and related histological changes. Additionally, GI-GVHD causes intestinal immune system disorders, damages intestinal epithelia...
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Hao Ji Shuai Feng Yuan Liu Yue Cao HuiQuan Lou Zengzheng Li Source Type: research
Identification and characterization of two immune-related subtypes in human chronic kidney disease
CONCLUSION: Among 131 DEIRG genes, four genes (PTPRC, CD69, CD8A, and CD28) were identified as potential biomarkers associated with the immune cell infiltration in CKD patients, which may provide a novel insight for immunotherapy for CKD.PMID:38184215 | DOI:10.1016/j.trim.2023.101983 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Xiangdong Fang Yanxia Chen Yan Chen Minzi Qiu Jinjing Huang Ben Ke Source Type: research
Validation of the kidney donor profile index (KDPI) for deceased donor kidney transplants in China
CONCLUSION: We recommend that the KDPI scoring system can be employed as an effective tool to predict kidney transplantation outcomes in deceased donation in China.PMID:38184216 | DOI:10.1016/j.trim.2023.101961 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Bo Yu Yiting Liu Tianyu Wang Yalong Zhang Jiayu Guo Chenyang Kong Zhongbao Chen Xiaoxiong Ma Jiangqiao Zhou Tao Qiu Source Type: research
Relationships, race/ethnicity, gender, age, and living kidney donation evaluation willingness
Transpl Immunol. 2024 Jan 4:101980. doi: 10.1016/j.trim.2023.101980. Online ahead of print.ABSTRACTRacial/ethnic and gender disparities in living donor kidney transplantation are large and persistent but incompletely explained. One previously unexplored potential contributor to these disparities is differential willingness to donate to recipients in specific relationships such as children, parents, and friends. We collected and analyzed data from an online sample featuring an experimental vignette in which respondents were asked to rate their willingness to donate to a randomly chosen member of their family or social netwo...
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Jonathan Daw Mary K Roberts Zarmeen Salim Nathaniel D Porter Ashton M Verdery Selena E Ortiz Source Type: research
