Serum IL-6 predicts risk of kidney transplant failure independently of immunological risk
In this study, we aimed to determine whether serum IL-6 levels are associated with immunological risk, allograft rejection and outcomes in kidney transplant (Ktx) patients. We retrospectively analyzed the data of 104 patients who underwent Ktx at our center between 2011 and 2015. The patients were divided into high- and low-risk groups (n = 52 per group) based on panel reactive antibody (PRA) percentage ≥ 35%, the existence of pre-Ktx donor-specific antibodies (DSA), or a previous transplant. IL-6 concentrations were measured before and at 3 months, 12 months, and 3 years after Ktx. Serum IL-6 levels tended to be higher ...
Source: Transplant Immunology - March 28, 2024 Category: Transplant Surgery Authors: Julius Friedmann Antonia Schuster Simone Reichelt-Wurm Bernhard Banas Tobias Bergler Louisa Steines Source Type: research
Nocardiosis in kidney transplant recipients: A tertiary care center experience
CONCLUSION: Nocardia may cause a late-manifesting infection beyond the traditional window. The cotrimoxazole prophylaxis may not be sufficient for Nocardia prevention.PMID:38537681 | DOI:10.1016/j.trim.2024.102041 (Source: Transplant Immunology)
Source: Transplant Immunology - March 27, 2024 Category: Transplant Surgery Authors: Rungmei Marak None Abdullah Manas Behera Anupma Kaul Dharmendra Bhaduaria Narayan Prasad Manas Patel Ravi Kushwaha Monika Yachha Source Type: research
Nocardiosis in kidney transplant recipients: A tertiary care center experience
CONCLUSION: Nocardia may cause a late-manifesting infection beyond the traditional window. The cotrimoxazole prophylaxis may not be sufficient for Nocardia prevention.PMID:38537681 | DOI:10.1016/j.trim.2024.102041 (Source: Transplant Immunology)
Source: Transplant Immunology - March 27, 2024 Category: Transplant Surgery Authors: Rungmei Marak None Abdullah Manas Behera Anupma Kaul Dharmendra Bhaduaria Narayan Prasad Manas Patel Ravi Kushwaha Monika Yachha Source Type: research
Circular RNA circEfnb2 promotes cell injury after cerebral infarction by sponging miR-202-5p and regulating TRAF3 expression
CONCLUSION: Our results suggest that circEfnb2 deficiency may decrease OGD/R-induced HT22 cell damage by modulating the miR-202-5p/TRAF3 axis. This explanation may provide a new direction for cerebral infarction potential therapeutic targets.PMID:38527707 | DOI:10.1016/j.trim.2024.102042 (Source: Transplant Immunology)
Source: Transplant Immunology - March 25, 2024 Category: Transplant Surgery Authors: Limin Tu Wei Cheng Xudong Wang Zhixin Li Xing Li Source Type: research
Circular RNA circEfnb2 promotes cell injury after cerebral infarction by sponging miR-202-5p and regulating TRAF3 expression
CONCLUSION: Our results suggest that circEfnb2 deficiency may decrease OGD/R-induced HT22 cell damage by modulating the miR-202-5p/TRAF3 axis. This explanation may provide a new direction for cerebral infarction potential therapeutic targets.PMID:38527707 | DOI:10.1016/j.trim.2024.102042 (Source: Transplant Immunology)
Source: Transplant Immunology - March 25, 2024 Category: Transplant Surgery Authors: Limin Tu Wei Cheng Xudong Wang Zhixin Li Xing Li Source Type: research
The contribution of the donor vascularised hand and face allograft in transplant rejection: An immunological perspective
Transpl Immunol. 2024 Mar 21;84:102035. doi: 10.1016/j.trim.2024.102035. Online ahead of print.ABSTRACTOvercoming immunological rejection remains a barrier to the safe adoption of Vascularised Composite Allotransplantation (VCA). To mitigate this risk, clinical protocols have been derived from solid organ transplantation, targeting recipient immunomodulation, yet VCA is unique. Face and hand composite allografts are composed of multiple different tissues, each with their own immunological properties. Experimental work suggests that allografts carry variable numbers and populations of donor leukocytes in an organ specific m...
Source: Transplant Immunology - March 22, 2024 Category: Transplant Surgery Authors: Kavit R Amin James E Fildes Source Type: research
Prior cytomegalovirus reactivation may lead to worse bacterial bloodstream infection outcomes in HSCT patients
CONCLUSIONS: CMV reactivation in BBSI patients is related to higher mortality 1-year after allo-HSCT. Further studies on a larger cohort are needed to better understanding the mechanism of CMV reactivation influence.PMID:38518827 | DOI:10.1016/j.trim.2024.102038 (Source: Transplant Immunology)
Source: Transplant Immunology - March 22, 2024 Category: Transplant Surgery Authors: Shanshan Li Yang Xiao Mei Jia Source Type: research
The contribution of the donor vascularised hand and face allograft in transplant rejection: An immunological perspective
Transpl Immunol. 2024 Mar 20:102035. doi: 10.1016/j.trim.2024.102035. Online ahead of print.ABSTRACTOvercoming immunological rejection remains a barrier to the safe adoption of Vascularised Composite Allotransplantation (VCA). To mitigate this risk, clinical protocols have been derived from solid organ transplantation, targeting recipient immunomodulation, yet VCA is unique. Face and hand composite allografts are composed of multiple different tissues, each with their own immunological properties. Experimental work suggests that allografts carry variable numbers and populations of donor leukocytes in an organ specific mann...
Source: Transplant Immunology - March 22, 2024 Category: Transplant Surgery Authors: Kavit R Amin James E Fildes Source Type: research
Prior cytomegalovirus reactivation may lead to worse bacterial bloodstream infection outcomes in HSCT patients
CONCLUSIONS: CMV reactivation in BBSI patients is related to higher mortality 1-year after allo-HSCT. Further studies on a larger cohort are needed to better understanding the mechanism of CMV reactivation influence.PMID:38518827 | DOI:10.1016/j.trim.2024.102038 (Source: Transplant Immunology)
Source: Transplant Immunology - March 22, 2024 Category: Transplant Surgery Authors: Shanshan Li Yang Xiao Mei Jia Source Type: research
The contribution of the donor vascularised hand and face allograft in transplant rejection: An immunological perspective
Transpl Immunol. 2024 Mar 20:102035. doi: 10.1016/j.trim.2024.102035. Online ahead of print.ABSTRACTOvercoming immunological rejection remains a barrier to the safe adoption of Vascularised Composite Allotransplantation (VCA). To mitigate this risk, clinical protocols have been derived from solid organ transplantation, targeting recipient immunomodulation, yet VCA is unique. Face and hand composite allografts are composed of multiple different tissues, each with their own immunological properties. Experimental work suggests that allografts carry variable numbers and populations of donor leukocytes in an organ specific mann...
Source: Transplant Immunology - March 22, 2024 Category: Transplant Surgery Authors: Kavit R Amin James E Fildes Source Type: research
Prior cytomegalovirus reactivation may lead to worse bacterial bloodstream infection outcomes in HSCT patients
CONCLUSIONS: CMV reactivation in BBSI patients is related to higher mortality 1-year after allo-HSCT. Further studies on a larger cohort are needed to better understanding the mechanism of CMV reactivation influence.PMID:38518827 | DOI:10.1016/j.trim.2024.102038 (Source: Transplant Immunology)
Source: Transplant Immunology - March 22, 2024 Category: Transplant Surgery Authors: Shanshan Li Yang Xiao Mei Jia Source Type: research
Predictors of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation: Insights from a real-world experience
CONCLUSIONS: CMV disease leads to significantly inferior survival after an allogeneic hematopoietic cell transplantation. Recipient CMV seropositive status was associated with the risk of CMV viremia and CMV disease, and this was not abrogated with the use of Letermovir prophylaxis.PMID:38513813 | DOI:10.1016/j.trim.2024.102039 (Source: Transplant Immunology)
Source: Transplant Immunology - March 21, 2024 Category: Transplant Surgery Authors: Matthew McGuirk Moazzam Shahzad Muhammad Kashif Amin Muhammad Atif Khan Polina Bellman Dinesh Pal Mudaranthakam Shaun DeJarnette Forat Lutfi Nausheen Ahmed Rajat Bansal Haitham Abdelhakim Chelsea Gorsline Dennis Matthew Shoemaker Al-Ola Abdallah Leyla Shu Source Type: research
Predictors of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation: Insights from a real-world experience
CONCLUSIONS: CMV disease leads to significantly inferior survival after an allogeneic hematopoietic cell transplantation. Recipient CMV seropositive status was associated with the risk of CMV viremia and CMV disease, and this was not abrogated with the use of Letermovir prophylaxis.PMID:38513813 | DOI:10.1016/j.trim.2024.102039 (Source: Transplant Immunology)
Source: Transplant Immunology - March 21, 2024 Category: Transplant Surgery Authors: Matthew McGuirk Moazzam Shahzad Muhammad Kashif Amin Muhammad Atif Khan Polina Bellman Dinesh Pal Mudaranthakam Shaun DeJarnette Forat Lutfi Nausheen Ahmed Rajat Bansal Haitham Abdelhakim Chelsea Gorsline Dennis Matthew Shoemaker Al-Ola Abdallah Leyla Shu Source Type: research
Effect of a Hispanic outreach program on referral and liver transplantation volume at a single center
CONCLUSIONS: A targeted outreach program for Hispanic patients with end-stage liver disease effectively increased the total number of Hispanic LT referrals and recipients. However, many of the patients who were referred were ineligible for LT, most frequently for financial reasons. These results highlight the need for additional research into the most effective ways to ameliorate financial barriers to LT in this high-need community.PMID:38499048 | DOI:10.1016/j.trim.2024.102034 (Source: Transplant Immunology)
Source: Transplant Immunology - March 18, 2024 Category: Transplant Surgery Authors: Sudha Kodali Constance M Mobley Elizabeth W Brombosz Analisa Lopez Riki Graves John Ontiveros Marcela Velazquez Ashish Saharia Yee Lee Cheah Caroline J Simon Christian Valverde Alphonse Brown Julie Corkrean Linda W Moore Edward A Graviss David W Victor Ke Source Type: research
Efficacy and safety of cladribine in combination with busulfan and cyclophosphamide as an intensive conditioning regimen preceding allogeneic hematopoietic stem cell transplantation in relapsed or refractory acute myeloid leukemia
CONCLUSION: Cladribine plus BuCy intensive conditioning regimen before allo-HSCT exhibits favorable treatment efficacy with acceptable toxicity in R/R AML patients.PMID:38499049 | DOI:10.1016/j.trim.2024.102037 (Source: Transplant Immunology)
Source: Transplant Immunology - March 18, 2024 Category: Transplant Surgery Authors: Fang Xiao Huanxu Guo Xueqian Yan Meiying Qi Jingyi Zhang Source Type: research
