Protective effects and mechanisms of dapagliflozin on renal ischemia/reperfusion injury
CONCLUSION: These findings documented that dapagliflozin protected kidneys from I/R injury suggesting its therapeutic potential.PMID:38325526 | DOI:10.1016/j.trim.2024.102010 (Source: Transplant Immunology)
Source: Transplant Immunology - February 7, 2024 Category: Transplant Surgery Authors: None Qiuxiao-Zhu None Huiyao-Hao Na Li None Zibo-Liu None Qian-Wang None Linyi-Shu None Lihui-Zhang Source Type: research
Hemophagocytic lymphohistiocytosis after solid organ transplantation: A challenge for clinicians
Transpl Immunol. 2024 Feb 1;83:102007. doi: 10.1016/j.trim.2024.102007. Online ahead of print.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a rare inflammatory disorder with a high mortality rate and a wide range of symptoms. Solid organ transplantation, which provides patients with a unique immunosuppressive state, is a less common predisposing factor for HLH. HLH after solid organ transplantation (HLH-SOT) is very rare and fatal. It is hard to diagnose and treat and extremely understudied. The use of immunosuppressants makes the situation of HLH-SOT more complex. This review summarizes the existing literature on HL...
Source: Transplant Immunology - February 2, 2024 Category: Transplant Surgery Authors: Shanshan Xu Kang He Source Type: research
Efficacy and Safety in Early application of Ruxolinitib for high-risk: Acute lymphoblastic leukemia to prevent GVHD and recurrence after allogeneic hematopoietic stem cell transplantation
CONCLUSIONS: Our preliminary observations suggest that an early application of ruxolitinib can safely and effectively prevent the occurrence of GVHD after allo-HSCT for the high-risk ALL patients. However, ruxolitinib may have a limited effect on preventing the ALL recurrence of high-risk patients.PMID:38302005 | DOI:10.1016/j.trim.2023.101978 (Source: Transplant Immunology)
Source: Transplant Immunology - February 1, 2024 Category: Transplant Surgery Authors: Qian Cheng Yishu Tang Feiyang Liu Xin Li Dan Fang Source Type: research
Interleukin-10 GCC/GCC haplotype is associated high risk of acute GVHD in patients undergoing allogeneic HSCT in the southern of Brazil
CONCLUSION: The results obtained show the IL-10 GCC/GCC haplotype can be an important biomarker to identify the greatest risk of aGVHD in the patient undergoing HSCT.PMID:38286299 | DOI:10.1016/j.trim.2024.102002 (Source: Transplant Immunology)
Source: Transplant Immunology - January 29, 2024 Category: Transplant Surgery Authors: Mariela Granero Farias Camila Andrade Dos Santos Alessandra Aparecida Paz Liane Esteves Daudt Source Type: research
Nephrotic proteinuria and hematuria with newly diagnosed IgA nephropathy after liver transplant: A case report
CONCLUSION: We reported a liver recipient, who was taking sirolimus, developing nephrotic proteinuria and hematuria with IgA nephropathy. Further studies need to be carried out to disclose mechanism behind this phenomenon.PMID:38272322 | DOI:10.1016/j.trim.2024.102003 (Source: Transplant Immunology)
Source: Transplant Immunology - January 25, 2024 Category: Transplant Surgery Authors: Tingli Wang Honghong Ren Dan Yin Hongyu Qiu Source Type: research
Exploration of the shared gene signatures and biological mechanisms between ischemia-reperfusion injury and antibody-mediated rejection in renal transplantation
CONCLUSION: Inflammation is a key mechanism that links IRI and ABMR, with a potential role played by CD4 memory T cells. Furthermore, TNFAIP3, IRF1, and EGR2 are implicated in the underlying mechanism between IRI and ABMR.PMID:38266883 | DOI:10.1016/j.trim.2024.102001 (Source: Transplant Immunology)
Source: Transplant Immunology - January 24, 2024 Category: Transplant Surgery Authors: Shan Jiang Hua Su Source Type: research
Probiotics, gut microbiome, and cardiovascular diseases: An update
Transpl Immunol. 2024 Jan 21;83:102000. doi: 10.1016/j.trim.2024.102000. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are one of the most challenging diseases and many factors have been demonstrated to affect their pathogenesis. One of the major factors that affect CVDs, especially atherosclerosis, is the gut microbiota (GM). Genetics play a key role in linking CVDs with GM, in addition to some environmental factors which can be either beneficial or harmful. The interplay between GM and CVDs is complex due to the numerous mechanisms through which microbial components and their metabolites can influence CVDs....
Source: Transplant Immunology - January 23, 2024 Category: Transplant Surgery Authors: Laura Dosh Maya Ghazi Karim Haddad Jad El Masri Jihad Hawi Angelo Leone Charbel Basset Alice Gerges Geagea Rosalyn Jurjus Abdo Jurjus Source Type: research
Retraction notice to "Inhibition of miR-495-3p ameliorated sevoflurane induced damage through BDNF/ERK/CREB signaling pathways in HT22 cells" [Transplant Immunology, Volume75, December 2022, 101708]
Transpl Immunol. 2024 Jan 18:101992. doi: 10.1016/j.trim.2024.101992. Online ahead of print.NO ABSTRACTPMID:38242727 | DOI:10.1016/j.trim.2024.101992 (Source: Transplant Immunology)
Source: Transplant Immunology - January 19, 2024 Category: Transplant Surgery Authors: Xiaomei Chen Chongyi Li Rui Zeng Ling Qiu Jianhang Huang Ning Wang Xia Ren Xingwu Lin Source Type: research
Renal transplantation for infantile and juvenile cystinosis: Two case report and review of the literature
This report discusses the outcomes of two young adult patients of Middle Eastern descent with cystinosis who underwent KT. The first patient, diagnosed with infantile nephropathic cystinosis treated by cystine-depleting therapy, was operated by KT at the age of 18. The second patient, diagnosed with juvenile cystinosis, underwent transplantation at the age of 35 after being treated with hemodialysis. Our report describes detailed pre- and postoperative managements, including laboratory results, and pharmacological interventions. Both cases highlighted the varying clinical manifestations and disease severity between infanti...
Source: Transplant Immunology - January 15, 2024 Category: Transplant Surgery Authors: Karen El Ghoul Dany Akiki Nagi Nawfal Maroun Abou Jaoude Source Type: research
The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation
CONCLUSIONS: Higher leptin levels and low values of IL-10 might play a role in rejection and de novo DSA production.PMID:38218229 | DOI:10.1016/j.trim.2023.101982 (Source: Transplant Immunology)
Source: Transplant Immunology - January 13, 2024 Category: Transplant Surgery Authors: Ivana Dedinsk á Patr ícia Kleinová Katar ína Macháleková Karol Gra ňák Matej Vnu čák Monika Belian činová Source Type: research
Upregulation of IDO gene expression reduces the immunogenicity of epidermal cells and strengthens the immune protection of epidermal cells during transplantation treatment of wounds
CONCLUSION: Our results suggest that the upregulation of IDO expression in epidermal stem cells can reduce their immunogenicity by promoting Tregs, thus inducing the immune protection of epidermal stem cells.PMID:38218230 | DOI:10.1016/j.trim.2024.101987 (Source: Transplant Immunology)
Source: Transplant Immunology - January 13, 2024 Category: Transplant Surgery Authors: Kun Zhang Xinzhu Liu Peng Luo Zhisheng Li Hongqing Zhao Dawei Li Zhaoxing Liu Bohan Zhang Chuanan Shen Source Type: research
Tacrolimus impairs airway mucociliary clearance of rats
CONCLUSIONS: TAC impairs airway mucociliary clearance of rats.PMID:38199268 | DOI:10.1016/j.trim.2024.101990 (Source: Transplant Immunology)
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: Maristela Prado E Silva S ônia de Fátima Soto Francine Maria de Almeida Aristides Tadeu Correia Paulo Manuel P êgo-Fernandes Rogerio Pazetti Source Type: research
Investigating the effect of pre-transplant thrombocytopenia and anemia on the engraftment and long-term survival in multiple myeloma patients
CONCLUSION: Thrombocytopenia and anemia before transplantation are related to slower Plt/WBC engraftment and as prognostic factors might predict the long-term survival of MM patients following ASCT.PMID:38199269 | DOI:10.1016/j.trim.2024.101991 (Source: Transplant Immunology)
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: Dariush Kadkhoda Maryam Nikoonezhad Hossein Bonakchi Mahshid Mehdizadeh Abbas Hajifathali Ahmad Reza Baghestani Leila Jabarinanva Ali Akbar Khadem Maboudi Source Type: research
Allogeneic hematopoietic stem cell transplantation: A single-center experience, 2017 to 2021
CONCLUSION: Donor type and donor age significantly impacted HSCT outcomes in our analysis, thus emphasizing the importance of rigorous donor selection in risk stratification and suggesting potential benefits for younger donors.PMID:38199270 | DOI:10.1016/j.trim.2024.101989 (Source: Transplant Immunology)
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: Patr ícia Cristina Lopes da Silva Guilherme Campos Muzzi Maressa Ribeiro Vilela Raquel A Fabreti-Oliveira Source Type: research
Conversion from calcineurin inhibitors to belatacept-based immunosuppressive therapy skews terminal proliferation of non-classical monocytes and lowers lymphocyte counts
Transpl Immunol. 2024 Feb;82:101976. doi: 10.1016/j.trim.2023.101976. Epub 2024 Jan 8.ABSTRACTBelatacept, a modified form of CTLA-Ig that blocks CD28-mediated co-stimulation of T cells, is an immune-suppressant that can be used as an alternative to calcineurin inhibitors (CNIs). In kidney transplant recipients, belatacept has been associated with improved renal function and reduced cardiovascular toxicity. Monocytes as well as T-lymphocytes play causal roles in the pathophysiology of atherosclerotic disease. We hypothesized that the beneficial impact of the use of belatacept over CNIs on cardiovascular risk could be partly...
Source: Transplant Immunology - January 10, 2024 Category: Transplant Surgery Authors: O W Bredewold A M van Oeveren-Rietdijk B Florijn J I Rotmans J W de Fijter C van Kooten A J van Zonneveld H C de Boer Source Type: research
