The administration of oral mucosal mesenchymal-derived stem cells improves hepatic inflammation, oxidative stress, and histopathology following traumatic brain injury
CONCLUSION: Therapy with i.v. OMSCs administration after TBI reduces liver injury, as measured by inflammation and oxidative stress. The use of OMSCs can be considered for treatment of liver injury caused by TBI.PMID:37918577 | DOI:10.1016/j.trim.2023.101950 (Source: Transplant Immunology)
Source: Transplant Immunology - November 2, 2023 Category: Transplant Surgery Authors: Eshagh Alizadeh Nazanin Sabet Zahra Soltani Mohammad Khaksari Elham Jafari Saeed Karamouzian Source Type: research
Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation
CONCLUSION: Polymorphisms in the Sestrin2/Sestrin3/ mTOR gene may confer certain protection/predisposition for NODAT.PMID:37918578 | DOI:10.1016/j.trim.2023.101947 (Source: Transplant Immunology)
Source: Transplant Immunology - November 2, 2023 Category: Transplant Surgery Authors: Don Vu Tariq Shah Prashant Sakharkar David I Min Source Type: research
The frequency of peripheral PD-1 < sup > + < /sup > TCD4 < sup > + < /sup > cells is reversely associated with serum creatinine levels in recipients of kidney allografts
Transpl Immunol. 2023 Oct 31:101946. doi: 10.1016/j.trim.2023.101946. Online ahead of print.ABSTRACTThe long-term survival of solid organ allografts remains a challenge for organ transplantation systems worldwide. T-cell exhaustion has been supposed to be associated with immunologic tolerance in transplantation and might reflect the immunologic status in recipients. The aim of the present study was to compare the TCD4+ cells of kidney transplant recipients with high and low serum creatinine levels for their expressions of PD-1 and TIGIT as two well-known exhaustion markers. Blood samples were taken from 20 kidney allograft...
Source: Transplant Immunology - November 2, 2023 Category: Transplant Surgery Authors: Alireza Mardomi Maryam KarajiBani Farahnoosh Farnood Sepideh Zununi Vahed Mohmmadreza Ardalan Source Type: research
Temsirolimus is a promising immunomodulatory agent for enhanced transplantation outcomes
CONCLUSIONS: Temsirolimus exhibited potent immunosuppressive effects, emerging as a strong candidate to mitigate organ transplant rejection.PMID:37918580 | DOI:10.1016/j.trim.2023.101952 (Source: Transplant Immunology)
Source: Transplant Immunology - November 2, 2023 Category: Transplant Surgery Authors: Xianguo Li Zuojie Peng Ke An Mengjiao Xue Zhenzhen Wang Junjie Xia Zhongquan Qi Xiaogang Shu Source Type: research
Asarinin inhibits immunological rejection via the Toll-like receptor-myeloid differentiation factor 88 signaling pathway in vitro
Transpl Immunol. 2023 Oct 31:101949. doi: 10.1016/j.trim.2023.101949. Online ahead of print.ABSTRACTAsarinin has been found to prolong allograft survival and inhibit post-transplant immune rejection via the Toll-like receptor (TLR) signaling pathway. However, the underlying mechanism is not completely understood. Therefore, elucidating the possible pathophysiological role of asarinin in the TLR signaling pathway is essential. Here, dendritic cells were isolated from Sprague-Dawley® rats and cultured with splenocytes from Wistar rats treated with asarinin, lipopolysaccharide (LPS), and/or dimethyl sulfoxide. mRNA expressio...
Source: Transplant Immunology - November 2, 2023 Category: Transplant Surgery Authors: Lili Zhang Yanxia Sun Zhen Yang Ping Xia Source Type: research
Research progress on CD8+ T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21;81:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide f...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
Research progress on CD8+ T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21;81:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide f...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
Research progress on CD8+ T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21;81:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide f...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
Research progress on CD8+ T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21;81:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide f...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
Research progress on CD8+ T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21;81:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide f...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
Research progress on CD8 + T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide fres...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
Research progress on CD8 + T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide fres...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
Research progress on CD8 + T cell immune regulation in allogenic transplantation
Transpl Immunol. 2023 Oct 21:101945. doi: 10.1016/j.trim.2023.101945. Online ahead of print.ABSTRACTWith advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse reactions and complications. Therefore, there is a continuing need to explore new immunological approaches to provide fres...
Source: Transplant Immunology - October 23, 2023 Category: Transplant Surgery Authors: Haowen Jiang Wenmei Fan Source Type: research
The potential of mesenchymal stem cells to induce immune tolerance to allogeneic transplants
Transpl Immunol. 2023 Oct 20:101939. doi: 10.1016/j.trim.2023.101939. Online ahead of print.ABSTRACTOrgan allograft transplantation is an effective treatment plan for patients with organ failure. Although the application of continuous immunosuppressants makes successful allograft survival possible, the patients' long-term survival rate and quality of life are not ideal. Therefore, it is necessary to find a new strategy to alleviate transplant rejection by developing therapies for permanent allograft acceptance. One promising approach is the application of tolerogenic mesenchymal stem cells (MSCs). Extensive research on MSC...
Source: Transplant Immunology - October 22, 2023 Category: Transplant Surgery Authors: Shaochen Yu Jian Lu Source Type: research
In persons with CIDP, auto-HSCT can be conducted fully on an outpatient basis and induces significant clinical responses: A prospective study in a single center
CONCLUSION: aHSCT conducted fully in an outpatient basis, employing the conditioning regimen of the "Mexican method" appears to be a feasible therapeutic option for persons with CIDP. Additional studies are needed to confirm these observations.PMID:37866669 | DOI:10.1016/j.trim.2023.101944 (Source: Transplant Immunology)
Source: Transplant Immunology - October 22, 2023 Category: Transplant Surgery Authors: Merittzel Abigail Montes-Robles Mois és Manuel Gallardo-Pérez Edgar J Hern ández-Flores Mar ía de Lourdes Pastelín-Martínez Daniela S ánchez-Bonilla Max Robles-Nasta Guillermo Oca ña-Ramm Juan Carlos Olivares-Gazca Guillermo J Ruiz-Delgado Guiller Source Type: research
