Advances in the mechanisms related to follicle loss after frozen-thawed ovarian tissue transplantation
Transpl Immunol. 2023 Sep 20:101935. doi: 10.1016/j.trim.2023.101935. Online ahead of print.ABSTRACTOvaries are important reproductive and endocrine organs in women. Ovarian tissue cryopreservation and transplantation technology can not only solve the fertility problems of patients, but also may improve female endocrine problems. This is particularly important for patients in urgent need of radiotherapy and chemotherapy, and for women with prepubertal malignant tumors. However, follicle loss after freeze-thawing is a key challenge for effective ovarian tissue transplantation and leads to poor transplant outcomes. Therefore...
Source: Transplant Immunology - September 22, 2023 Category: Transplant Surgery Authors: Changli Han Qin Zeng Libing He Zonghui Luan Ruyue Liu Guohui Zhang Weixin Liu Source Type: research
An analysis of the relationship between donor and recipient biomarkers and kidney graft function, dysfunction, and rejection
CONCLUSIONS: Donor serum TIMP-2 and uNAG levels are useful predictive biomarkers because they can provide the donor-based prediction for RGF.PMID:37739236 | DOI:10.1016/j.trim.2023.101934 (Source: Transplant Immunology)
Source: Transplant Immunology - September 22, 2023 Category: Transplant Surgery Authors: Yi-Jie Mao Dong-Sheng Xu Shuang-De Liu Jie-Ke Yan Xiao-Li Liu Xu-Feng Zhang Wen-Gu Pan Chuan Tian Source Type: research
Advances in the mechanisms related to follicle loss after frozen-thawed ovarian tissue transplantation
Transpl Immunol. 2023 Sep 20:101935. doi: 10.1016/j.trim.2023.101935. Online ahead of print.ABSTRACTOvaries are important reproductive and endocrine organs in women. Ovarian tissue cryopreservation and transplantation technology can not only solve the fertility problems of patients, but also may improve female endocrine problems. This is particularly important for patients in urgent need of radiotherapy and chemotherapy, and for women with prepubertal malignant tumors. However, follicle loss after freeze-thawing is a key challenge for effective ovarian tissue transplantation and leads to poor transplant outcomes. Therefore...
Source: Transplant Immunology - September 22, 2023 Category: Transplant Surgery Authors: Changli Han Qin Zeng Libing He Zonghui Luan Ruyue Liu Guohui Zhang Weixin Liu Source Type: research
An analysis of the relationship between donor and recipient biomarkers and kidney graft function, dysfunction, and rejection
CONCLUSIONS: Donor serum TIMP-2 and uNAG levels are useful predictive biomarkers because they can provide the donor-based prediction for RGF.PMID:37739236 | DOI:10.1016/j.trim.2023.101934 (Source: Transplant Immunology)
Source: Transplant Immunology - September 22, 2023 Category: Transplant Surgery Authors: Yi-Jie Mao Dong-Sheng Xu Shuang-De Liu Jie-Ke Yan Xiao-Li Liu Xu-Feng Zhang Wen-Gu Pan Chuan Tian Source Type: research
Durable complete response to early immunotherapy discontinuation in a kidney transplant recipient with advanced cutaneous squamous cell carcinoma: A case report and review of literature
CONCLUSION: Organ transplant recipients with complete response to immunotherapy for cutaneous squamous cell carcinoma may continue to respond despite early treatment cessation. This may reduce the risks of late immune-related adverse events and acute graft rejection.PMID:37734447 | DOI:10.1016/j.trim.2023.101932 (Source: Transplant Immunology)
Source: Transplant Immunology - September 21, 2023 Category: Transplant Surgery Authors: Ziyao Lu Mohammed Afzal Keisuke Shirai Source Type: research
Durable complete response to early immunotherapy discontinuation in a kidney transplant recipient with advanced cutaneous squamous cell carcinoma: A case report and review of literature
CONCLUSION: Organ transplant recipients with complete response to immunotherapy for cutaneous squamous cell carcinoma may continue to respond despite early treatment cessation. This may reduce the risks of late immune-related adverse events and acute graft rejection.PMID:37734447 | DOI:10.1016/j.trim.2023.101932 (Source: Transplant Immunology)
Source: Transplant Immunology - September 21, 2023 Category: Transplant Surgery Authors: Ziyao Lu Mohammed Afzal Keisuke Shirai Source Type: research
Association between blood transfusion after kidney transplantation and risk for the development of de novo HLA donor-specific antibodies and poor clinical outcomes: A single-center retrospective study
CONCLUSIONS: Our study showed that blood transfusion after transplantation is associated with the occurrence of de novo DSAs increasing an immunological risk for poor clinical outcomes for kidney transplantation recipients.PMID:37730183 | DOI:10.1016/j.trim.2023.101930 (Source: Transplant Immunology)
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Zhong-Yu Kang Chun Liu Wei Liu Daihong Li Source Type: research
Bioequivalence evaluation and blood concentration estimation of generic and branded tacrolimus in healthy subjects under fasting: A randomized, four-periods, two-sequences, complete repeated, crossover study
CONCLUSION: Generic tacrolimus (Ruibeirong®) is bioequivalent to branded tacrolimus (Astagraf XL®) with tolerable safety, which AUC predictive equations work well and are interchangeable between the two products.PMID:37730184 | DOI:10.1016/j.trim.2023.101933 (Source: Transplant Immunology)
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Yulin Niu Gongbin Lan Jina Wang Tianzhong Yan Peng Jin Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.202...
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Association between blood transfusion after kidney transplantation and risk for the development of de novo HLA donor-specific antibodies and poor clinical outcomes: A single-center retrospective study
CONCLUSIONS: Our study showed that blood transfusion after transplantation is associated with the occurrence of de novo DSAs increasing an immunological risk for poor clinical outcomes for kidney transplantation recipients.PMID:37730183 | DOI:10.1016/j.trim.2023.101930 (Source: Transplant Immunology)
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Zhong-Yu Kang Chun Liu Wei Liu Daihong Li Source Type: research
Bioequivalence evaluation and blood concentration estimation of generic and branded tacrolimus in healthy subjects under fasting: A randomized, four-periods, two-sequences, complete repeated, crossover study
CONCLUSION: Generic tacrolimus (Ruibeirong®) is bioequivalent to branded tacrolimus (Astagraf XL®) with tolerable safety, which AUC predictive equations work well and are interchangeable between the two products.PMID:37730184 | DOI:10.1016/j.trim.2023.101933 (Source: Transplant Immunology)
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Yulin Niu Gongbin Lan Jina Wang Tianzhong Yan Peng Jin Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.202...
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Identification of biomarkers of renal ischemia-reperfusion injury by bioinformatics analysis and single-cell sequencing analysis combined with in vivo validation
CONCLUSION: cyp1a1 and pdk4 were identified to play important roles in renal IRI. This research provides a new perspective and basis for studying the pathogenesis of renal IRI and developing new treatments.PMID:37704087 | DOI:10.1016/j.trim.2023.101928 (Source: Transplant Immunology)
Source: Transplant Immunology - September 13, 2023 Category: Transplant Surgery Authors: Qin Zhu Shiqi Ren Zhaoyang Sun Jun Qin Xiaoming Sheng Source Type: research
Identification of biomarkers of renal ischemia-reperfusion injury by bioinformatics analysis and single-cell sequencing analysis combined with in vivo validation
CONCLUSION: cyp1a1 and pdk4 were identified to play important roles in renal IRI. This research provides a new perspective and basis for studying the pathogenesis of renal IRI and developing new treatments.PMID:37704087 | DOI:10.1016/j.trim.2023.101928 (Source: Transplant Immunology)
Source: Transplant Immunology - September 13, 2023 Category: Transplant Surgery Authors: Qin Zhu Shiqi Ren Zhaoyang Sun Jun Qin Xiaoming Sheng Source Type: research
Identification of biomarkers of renal ischemia-reperfusion injury by bioinformatics analysis and single-cell sequencing analysis combined with in vivo validation
CONCLUSION: cyp1a1 and pdk4 were identified to play important roles in renal IRI. This research provides a new perspective and basis for studying the pathogenesis of renal IRI and developing new treatments.PMID:37704087 | DOI:10.1016/j.trim.2023.101928 (Source: Transplant Immunology)
Source: Transplant Immunology - September 13, 2023 Category: Transplant Surgery Authors: Qin Zhu Shiqi Ren Zhaoyang Sun Jun Qin Xiaoming Sheng Source Type: research
