Caffeine and naloxone treated mesenchymal stem cells improve symptoms and reduce inflammation in a mouse model of ulcerative colitis
CONCLUSION: MSCs treated with caffeine and naloxone can enhance the immunoregulatory potential of these. As a result, treated MSCs can lead to improved clinical signs and reduced inflammatory parameters in mice with UC, making this approach a useful way for controlling and treating the disease. However, additional research is needed to access the mechanism behind the stronger immune system regulatory effects of treated MSCs in UC treatment.PMID:38184213 | DOI:10.1016/j.trim.2024.101986 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Milad Beygi Jalal Shayegh Hadi Esmaeili Gouvarchin Ghaleh Source Type: research
Effect of GVHD on the gut and intestinal microflora
Transpl Immunol. 2024 Jan 4:101977. doi: 10.1016/j.trim.2023.101977. Online ahead of print.ABSTRACTGraft-versus-host disease (GVHD) is one of the most important cause of death in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The gastrointestinal tract is one of the most common sites affected by GVHD. However, there is no gold standard clinical practice for diagnosing gastrointestinal GVHD (GI-GVHD), and it is mainly diagnosed by the patient's clinical symptoms and related histological changes. Additionally, GI-GVHD causes intestinal immune system disorders, damages intestinal epithelia...
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Hao Ji Shuai Feng Yuan Liu Yue Cao HuiQuan Lou Zengzheng Li Source Type: research
Identification and characterization of two immune-related subtypes in human chronic kidney disease
CONCLUSION: Among 131 DEIRG genes, four genes (PTPRC, CD69, CD8A, and CD28) were identified as potential biomarkers associated with the immune cell infiltration in CKD patients, which may provide a novel insight for immunotherapy for CKD.PMID:38184215 | DOI:10.1016/j.trim.2023.101983 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Xiangdong Fang Yanxia Chen Yan Chen Minzi Qiu Jinjing Huang Ben Ke Source Type: research
Validation of the kidney donor profile index (KDPI) for deceased donor kidney transplants in China
CONCLUSION: We recommend that the KDPI scoring system can be employed as an effective tool to predict kidney transplantation outcomes in deceased donation in China.PMID:38184216 | DOI:10.1016/j.trim.2023.101961 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Bo Yu Yiting Liu Tianyu Wang Yalong Zhang Jiayu Guo Chenyang Kong Zhongbao Chen Xiaoxiong Ma Jiangqiao Zhou Tao Qiu Source Type: research
Relationships, race/ethnicity, gender, age, and living kidney donation evaluation willingness
Transpl Immunol. 2024 Jan 4:101980. doi: 10.1016/j.trim.2023.101980. Online ahead of print.ABSTRACTRacial/ethnic and gender disparities in living donor kidney transplantation are large and persistent but incompletely explained. One previously unexplored potential contributor to these disparities is differential willingness to donate to recipients in specific relationships such as children, parents, and friends. We collected and analyzed data from an online sample featuring an experimental vignette in which respondents were asked to rate their willingness to donate to a randomly chosen member of their family or social netwo...
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Jonathan Daw Mary K Roberts Zarmeen Salim Nathaniel D Porter Ashton M Verdery Selena E Ortiz Source Type: research
Influence of HLA-A, B, and -DRB1 genes and panel-reactive antibodies on the waitlist time for kidney transplantation in the state of Sao Paulo-Brazil
CONCLUSION: The length of stay on the waitlist is influenced by the frequency of the HLA alleles of the DRB1 locus and the degree of sensitization.PMID:38184218 | DOI:10.1016/j.trim.2023.101981 (Source: Transplant Immunology)
Source: Transplant Immunology - January 6, 2024 Category: Transplant Surgery Authors: Camila Ravazzi-Gauch Ludimila Leite Marzochi Miklos Maximiliano Bajay Marizete Peixoto Medeiros Heloisa Cristina Caldas Mario Abbud-Filho Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation
CONCLUSION: VEGF-R1 levels are found to be increased in pediatric patients developing SOS, reflecting the severity of morbidity. sVEGF-R1 were unassociated with both CLS and ES. The potential of sVEGF-R1 as a clinically useful biomarker for SOS should be further explored to improve pre-transplant SOS-risk assessment, SOS-severity grading, and to guide treatment.PMID:38122992 | DOI:10.1016/j.trim.2023.101975 (Source: Transplant Immunology)
Source: Transplant Immunology - December 20, 2023 Category: Transplant Surgery Authors: Denise Elb æk Horan Katrine Kielsen Sarah Wegener Weischendorff Maria Ebbesen S ørum Marte B Kammersgaard Marianne Ifversen Claus Nielsen Lars P Ryder P är I Johansson Klaus M üller Source Type: research
