Differential effects of peritoneal and hemodialysis on circulating regulatory T cells one month post initiation of renal replacement therapy.
Conclusionː Our study is the first to evaluate longitudinal effects of dialysis on Treg cells in uremia and suggests that PD was more effective in increasing Treg levels 1 month post initiation of dialysis and may contribute to improvement of inflammatory status. Thus, PD may contribute to better outcomes for patients with renal dysfunction, also maintaining homeostasis of peritoneal and renal tissues. PMID: 33074093 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 19, 2020 Category: Urology & Nephrology Authors: Caprara C, Corradi V, Scalzotto E, Frigo AC, Proglio M, Sharma R, Ronco C Tags: Clin Nephrol Source Type: research

Retrospective single-arm cohort study of steroid-dependent minimal change nephrotic syndrome treated with very low-dose rituximab.
Conclusions regarding the best rituximab (RTX) dose to maintain remission and reduce immunosuppressant dependence in adult patients with steroid-dependent minimal change nephrotic syndrome (MCNS) are inconsistent. We report the first low-dose (
Source: Clinical Nephrology - October 19, 2020 Category: Urology & Nephrology Authors: Fujimoto K, Kagaya Y, Kumano S, Fujii A, Tsuruyama Y, Matsuura T, Yamazaki K, Nomura K, Okada K, Okino K, Adachi H, Furuichi K, Yokoyama H Tags: Clin Nephrol Source Type: research

Gender in acute kidney disease: A  narrative review.
Gender in acute kidney disease: A narrative review. Clin Nephrol. 2020 Oct 19;: Authors: Ciarambino T, Para O, Giordano M Abstract Acute kidney injury (AKI) occurs in 3.2 - 9.6% of hospital admissions and in 2.1 - 22.1% of prevalent intensive care unit patients, worldwide. There is a sexual dimorphism in the AKI evolution with implications of sex hormones, endothelin etc. We provide a mini-review on the gender-related differences in the AKI evolution. PMID: 33074095 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 19, 2020 Category: Urology & Nephrology Authors: Ciarambino T, Para O, Giordano M Tags: Clin Nephrol Source Type: research

Long-term renal outcomes of IgA nephropathy presenting with different levels of proteinuria.
CONCLUSION: Patients with proteinuria levels> 0.30 g/d already have a higher risk of doubling of baseline Scr, suggesting the necessity of early intervention in patients presenting with minimal proteinuria. PMID: 32990213 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 28, 2020 Category: Urology & Nephrology Authors: Ai Z, Zhou Q, Huang F, Yang Q, Yu X Tags: Clin Nephrol Source Type: research

Haptoglobin phenotype among patients with  IgA nephropathy: Impact on disease progression and response to treatment.
CONCLUSION: The prevalence of Hp 1-1 phenotype is higher in IgAN patients than in the general population in Israel, and even more than in patients with CKD or subjects on hemodialysis. Patients with Hp 2-2 exhibited a better renal response to the routine therapies. PMID: 32909539 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Habbashe N, Kinaneh S, Hassan K, Armaly Z Tags: Clin Nephrol Source Type: research

The surge in nephrology consultations and inpatient dialysis services during the COVID-19 pandemic.
PMID: 32909540 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Hirsch JS, Uppal NN, Finger M, Barnett R, Fishbane S, Ng JH Tags: Clin Nephrol Source Type: research

An auspicious triumph of recovery from dialysis-requiring acute kidney injury in COVID-19 in a patient with chronic kidney disease, α-1 antitrypsin deficiency, and liver transplant: A case report.
We report a unique case of an immunosuppressed 67-year-old female with homozygous Z-allele mutation A1AT deficiency and liver transplant with baseline chronic kidney disease (CKD) stage IIIa with creatinine of 1 mg/dL and glomerular filtration rate (GFR) of 49 mL/min/1.73m2 ~ 6 months before the presentation. She presented with COVID-19 mediated hypoxic respiratory failure complicated by AKI requiring provisional renal replacement therapy with recovery of kidney function with a new baseline of creatinine of 1.6 - 1.8 mg/dL with GFR of 31 mL/min/1.73m2. PMID: 32909541 [PubMed - as supplied by publisher] ...
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: De Souza L, Nwanji V, Kaur G Tags: Clin Nephrol Source Type: research

Tonsillectomy for IgA nephropathy.
PMID: 32909542 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Geara AS Tags: Clin Nephrol Source Type: research

The case for tonsillectomy in IgA nephropathy.
PMID: 32909543 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Hilburg R, Coppock GM Tags: Clin Nephrol Source Type: research

The case against tonsillectomy in IgA nephropathy.
PMID: 32909544 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: El Kassis Y Tags: Clin Nephrol Source Type: research

Acute interstitial nephritis following treatment with direct-acting antiviral agents in hepatitis C virus-infected patients: A case series.
Abstract Hepatitis C virus (HCV) infection has been associated with several extrahepatic adverse clinical outcomes, including an accelerated rate of loss of kidney function in patients with chronic kidney disease (CKD) and an increased mortality in patients with CKD and kidney failure on hemodialysis. Clinical trials using direct-acting antiviral (DAA) agents have uniformly achieved sustained viral response at 12 weeks (SVR12) rates of> 90% in the general population as well as in patients with CKD/kidney failure on hemodialysis. Sofosbuvir is a DAA prodrug that is phosphorylated into the active metabo...
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Duque JC, Dejman A, Venkat V, Hernandez M, Roth D, Ladino MA Tags: Clin Nephrol Source Type: research

Outcomes of COVID-19-positive kidney transplant recipients: A single-center experience.
PMID: 32909546 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Katz-Greenberg G, Yadav A, Gupta M, Martinez-Cantarin MP, Gulati R, Ackerman L, Belden K, Singh P Tags: Clin Nephrol Source Type: research

Non-obstructive coronary angiogram findings prior to kidney transplantation do not predict post-transplant cardiac events.
CONCLUSION: Dialysis duration, morbid obesity, diabetes control, and tacrolimus levels may represent modifiable risk factors to reduce cardiac events in kidney transplant recipients with non-obstructive cardiac catheterization findings at the time of transplant. PMID: 32909547 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Aziz F, Dhingra R, Anders M, Parajuli S, Mandelbrot D, Djamali A Tags: Clin Nephrol Source Type: research

Peritoneal magnesium elimination and its  clinical relevance in peritoneal dialysis patients.
This study aims to evaluate the peritoneal magnesium elimination characteristics in comparison to other small solutes and the influence of peritoneal transport status. MATERIALS AND METHODS: Peritoneal elimination of magnesium, blood-urea-nitrogen (BUN), and creatinine during a 4-hour peritoneal equilibration test (PET) was assessed in 30 stable PD patients. Absolute magnesium elimination was compared overall and between creatinine transport tertiles. RESULTS: Median age was 61 years, 50% of patients were male, 20% were on automated PD treatment. Serum magnesium was 0.84 mmol/L, and dialysate magnesium at the end...
Source: Clinical Nephrology - September 6, 2020 Category: Urology & Nephrology Authors: Holzmann-Littig C, McCallum W, Heemann U, Renders L, Bietenbeck A, Steubl D Tags: Clin Nephrol Source Type: research

Infection-related glomerulonephritis mimicking lupus nephritis.
This report provides further detail regarding the patient's clinical issues. PMID: 32893813 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 6, 2020 Category: Urology & Nephrology Authors: Alawieh R, Satoskar A, Obole E, Hebert L, Ayoub I Tags: Clin Nephrol Source Type: research

Cobalt alloy hip prostheses and new-onset heart failure in patients with and without chronic kidney disease.
PMID: 32893814 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 6, 2020 Category: Urology & Nephrology Authors: Mavrakanas TA, Kamal O, Charytan DM Tags: Clin Nephrol Source Type: research

Cancer surveillance imaging: Does repeated iodinated contrast exposure impact long-term kidney function?
CONCLUSION: Older age, diabetes, and longer operating time, but not cumulative contrast exposure were found to be associated with worse long-term renal outcomes following surgical resection in patients with early-stage colorectal cancer who survived 3 years. PMID: 32870145 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Heinen J, Hsu M, Selby LV, Russo AE, Nash GM, Jaimes EA, Shingarev R Tags: Clin Nephrol Source Type: research

Safety and efficacy of placement of tunneled hemodialysis catheter without the use of fluoroscopy.
acute;zsi L, Rosivall L Abstract INTRODUCTION: The implantation of acute or chronic vascular accesses for hemodialysis (HD) in end-stage kidney disease patients is a critical skill procedure for nephrologists, with an impact on short- and long-term outcomes of the modality and patient survival. Placement circumstances, however, may depend on the availability of technological support and will likely vary across the world. MATERIALS AND METHODS: We retrospectively reviewed our local experience with ultrasound-guided tunneled dialysis catheter (TDC) insertions but without access to fluoroscopic guidance. Data we...
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Pethő Á, Tapolyai M, Szakács-Pál T, Orosz P, Dézsi L, Rosivall L Tags: Clin Nephrol Source Type: research

Long-term data on two sisters with C3GN due to an identical, homozygous CFH mutation and autoantibodies.
This study underlines the concept of a personalized-medicine approach in complement-associated diseases after thorough evaluation of the individual risk profile in each patient. PMID: 32870147 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Hackl A, Erger F, Skerka C, Wenzel A, Tschernoster N, Ehren R, Burgmaier K, Riehmer V, Licht C, Kirschfink M, Weber LT, Altmueller J, Zipfel PF, Habbig S Tags: Clin Nephrol Source Type: research

Nephrotic syndrome in the setting of LECT2 amyloidosis: Take a look at the podocyte.
In this report, we highlight the importance of amyloid typing, as the deposition of several amyloidotic proteins in the kidneys is not associated with heavy proteinuria. We present two cases of patients who presented with sudden-onset nephrotic syndrome and kidney biopsies showing interstitial, vascular, and/or mesangial LECT2 amyloidosis. Further examination by electron microscopy demonstrated diffuse foot process effacement consistent with minimal change disease and no amyloid deposition in the glomerular basement membrane. Both patients had complete remission after glucocorticoid treatment. We conclude that the presence...
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Valdés-Lagunes DA, Méndez-Pérez RA, de la Cruz MA, Uribe-Uribe NO, Mejía-Vilet JM Tags: Clin Nephrol Source Type: research

Pre-transplant AT1R antibodies and long-term outcomes in kidney transplant recipients with a functioning graft for more than 5 years.
CONCLUSION: Our study indicates that in patients with a functioning kidney allograft> 5 years, pre-transplant AT1R antibodies may be associated with a greater risk of rejection and late graft failure. PMID: 32870149 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Aziz F, Jung-Hynes B, Parajuli S, Redfield RR, Astor BC, Mandelbrot D, Hidalgo L, Djamali A Tags: Clin Nephrol Source Type: research

The potential additive role of PleurX drainage system in an end-stage renal disease patient on hemodialysis with persisting cardiac ascites.
uml;p T PMID: 32870150 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Okamoto K, Perry AM, Jenssen F, Ullian ME, Fülöp T Tags: Clin Nephrol Source Type: research

Effect of renin-angiotensin system blockers on contrast-induced acute kidney injury in patients with normal or mild-to-moderate reduced kidney function undergoing coronary angiography: A  systematic review and meta-analysis.
CONCLUSION: In patients with relatively-preserved renal function, the association of RAS blockers with an increased risk of CI-AKI after contrast media exposure was inconclusive, as sensitivity analysis showed conflicting results and bias. Although this study did not demonstrate significant evidence, it indicated that clinicians need to be vigilant in assessing the potential risk for RAS blockers to cause CI-AKI in low-risk patients. PMID: 32870151 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Yamada T, Fujisaki T, Chopra N, Yamaji T, Azushima K, Kobayashi R, Kinguchi S, Urate S, Suzuki T, Abe E, Wakui H, Tamura K, Steinberg D Tags: Clin Nephrol Source Type: research

Renal involvement and favorable outcome in a child with mastocytosis 
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Renal involvement and favorable outcome in a child with mastocytosis
. Clin Nephrol. 2020 Aug 24;: Authors: Cho H, Kim JY, Lee Y, Kwon GY Abstract Mastocytosis is a rare myeloproliferative disease in which mast cells abnormally accumulate in the skin, bone marrow, intestine, liver, spleen, and lymph nodes. Characterized by uncontrolled proliferation of aberrant mast cells, the disease can present either cutaneously or systemically. Mast cells facilitate the immune response and inflammation, and mastocytosis with renal involvement has been rarely reported in adults. Here, we describe a pediatric case...
Source: Clinical Nephrology - August 23, 2020 Category: Urology & Nephrology Authors: Cho H, Kim JY, Lee Y, Kwon GY Tags: Clin Nephrol Source Type: research

Acute kidney injury in ICU - Does it matter where?
PMID: 32729816 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 29, 2020 Category: Urology & Nephrology Authors: Heering P, Jones E, Schmitz M, Dlamini T, Rayner B Tags: Clin Nephrol Source Type: research

Serum Klotho is correlated to cardiovascular complications of chronic kidney disease in children 
.
CONCLUSION: (1) In children with CKD, decreased sKl might be a marker of elevated central blood pressure. (2) Both sKl decrease and FGF23 increase could possibly contribute to left ventricular hypertrophy in this group of patients. PMID: 32729817 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 29, 2020 Category: Urology & Nephrology Authors: Okarska-Napierała M, Skrzypczyk P, Pietrzak R, Stelmaszczyk-Emmel A, Górska E, Werner B, Pańczyk-Tomaszewska M Tags: Clin Nephrol Source Type: research

Etelcalcetide versus placebo for secondary hyperparathyroidism in patients receiving hemodialysis: A meta-analysis of randomized controlled trials 
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Etelcalcetide versus placebo for secondary hyperparathyroidism in patients receiving hemodialysis: A meta-analysis of randomized controlled trials
. Clin Nephrol. 2020 Jul 30;: Authors: Zhu Y, Ou J, Liu X, Xie Z Abstract AIMS: The aim of the study was to evaluate the efficacy and safety of etelcalcetide for the treatment of secondary hyperparathyroidism (SHPT) in patients receiving hemodialysis, and a meta-analysis was performed using randomized controlled trials (RCTs). MATERIALS AND METHODS: We searched studies published on PubMed, Cochrane Central Register of Controlled Trials, and Embase to...
Source: Clinical Nephrology - July 29, 2020 Category: Urology & Nephrology Authors: Zhu Y, Ou J, Liu X, Xie Z Tags: Clin Nephrol Source Type: research

Medicinal plants and renal failure: A case-control study.
Abstract AIMS: Medicinal plants contain many active constituents that can cause adverse effects on kidneys that are often unrecognized. The aim of our work was to study the association between the regular use of medicinal plants and the risk of chronic renal failure in hospitalized patients in four departments of Mohammed VI University Hospital. MATERIALS AND METHODS: A case-control study was performed from January 2018 to December 2018. The cases were patients with a first-time diagnosis of chronic renal failure and without family history of kidney diseases or pre-existing renal disease. One control was matc...
Source: Clinical Nephrology - July 26, 2020 Category: Urology & Nephrology Authors: Naouaoui S, Fadili W, Chettati M, Laouad I Tags: Clin Nephrol Source Type: research

From Bartter's syndrome to renal tubular acidosis in a patient with Hashimoto's thyroiditis: A case report 
.
We report an HT patient who initially developed hypokalemic metabolic alkalosis and then developed metabolic acidosis within a few years. To our knowledge, this is the first report of two completely opposite acid-base disturbances associated with renal tubular diseases occurring consecutively in the same patient with HT. Our case may provide a valuable clue for exploring the mechanism of renal involvement in autoimmune diseases. PMID: 32691728 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 20, 2020 Category: Urology & Nephrology Authors: Wang S, Dong B, Wang C, Lu J, Shao L Tags: Clin Nephrol Source Type: research

Clinicopathological features of IgG4-related kidney disease 
.
CONCLUSION: IgG4-RKD should be diagnosed by combining the clinical data and renal pathological changes, and it should be differentiated from a variety of diseases. Although ANCA-associated vasculitis (AAV) and IgG4-related disease are distinguishable in most cases, coexistence of ANCA-GN and IgG4-RKD should be considered in some special cases. PMID: 32691729 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 20, 2020 Category: Urology & Nephrology Authors: Zhang P, Yin Q, Wang W, Yao Q, Zou Y, Li G, Wang J Tags: Clin Nephrol Source Type: research

Co-infection with SARS-CoV-2 and parainfluenza virus in a hemodialysis patient: A case report 
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CONCLUSION: Our case underscores the possibility of SARS-CoV-2 co-infection with other pathogens in hemodialysis patients and the importance of early identification of COVID-19. PMID: 32691730 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 20, 2020 Category: Urology & Nephrology Authors: He H, Liao C, Wang R, Wu T, Zhang J, Hu C, Shui H Tags: Clin Nephrol Source Type: research

Prevalence of the NPHS2 variants p.R229Q, p.A242V, and p.R138Q in patients with focal segmental glomerulosclerosis 
.
CONCLUSION: In these patients with familial or sporadic FSGS, the prevalence of p.R229Q and p.A242V variants in children was 5% and in adults 12.9%. More studies of patients with FSGS could better define a strategy for genetic analysis and therapeutic management. PMID: 32691731 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 20, 2020 Category: Urology & Nephrology Authors: de Almeida R, da Silva WC, Garbin HI, Itaquy TP, Dos Santos Pereira F, Garcia CD, Keitel E, Sales Luiz Vianna F, Veronese FV Tags: Clin Nephrol Source Type: research

Planting a seed: Joining efforts to establish a successful, self-sustained kidney transplant program in Honduras.
PMID: 32631483 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 6, 2020 Category: Urology & Nephrology Authors: Castellanos AL, Valladares E, Strup S, Bautista B, Bendeck S, Gedaly R Tags: Clin Nephrol Source Type: research

Why do people waste differently on dialysis? Important insights from other chronic diseases with a focus on microRNAs.
Abstract Premature muscle tiring (fatigue) is an important complication of advanced kidney disease, and results in a reduced ability to walk and exercise. As patients move from pre-dialysis care to dialysis, they begin to lose their residual kidney function and experience muscle wasting. Not all patients on dialysis are affected equally by the loss of muscle mass, and the effect of dialysis mode (peritoneal dialysis and hemodialysis) on muscle wasting is not known. This review will explore molecular mechanisms relevant to muscle wasting in end-stage kidney disease and in particular address some important insights ...
Source: Clinical Nephrology - July 6, 2020 Category: Urology & Nephrology Authors: Navaratnarajah A, Brown EA, Kemp P Tags: Clin Nephrol Source Type: research

Fluid overload is an independent predictor of atrial fibrillation in end-stage renal disease: A  prospective study using insertable cardiac and body composition monitors
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CONCLUSION: The occurrence of AF is independently associated with BCM-measured fluid overload, which is common among ESRD patients.
. PMID: 32631485 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 6, 2020 Category: Urology & Nephrology Authors: Kaartinen K, Rautavaara J, Aitkoski A, Anttonen O, Ahvonen J, Vilpakka M, Koistinen J, Vääräniemi K, Miettinen M, Ylitalo A, Laine K, Ojanen S, Kerola T, Nieminen T Tags: Clin Nephrol Source Type: research

A formula predicting the effective dose of febuxostat in chronic kidney disease patients with asymptomatic hyperuricemia based on a retrospective study and a validation cohort 
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This study aimed to determine a formula that predicts the effective dose of febuxostat in patients with an estimated glomerular filtration rate (eGFR)
Source: Clinical Nephrology - June 25, 2020 Category: Urology & Nephrology Authors: Aoun M, Salloum R, Dfouni A, Sleilaty G, Chelala D Tags: Clin Nephrol Source Type: research

Investigation of methods for more accurate estimation of kidney function in people with high muscle mass 
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Investigation of methods for more accurate estimation of kidney function in people with high muscle mass
. Clin Nephrol. 2020 Jun 26;: Authors: Ichigi M, Nakatani S, Murakami M, Harada Y, Utsumi S, Ogata M, Maehara Y, Ikeda H, Shimada H, Fukunaga M, Narita Y, Saruwatari J, Kondo Y, Ishitsuka Y, Irie T, Kadowaki D, Hirata S Abstract Serum creatinine (SCr) levels depend on muscle mass and are therefore elevated in people with high muscle mass, potentially leading to underestimation of kidney function in this population. Although recent therapeutic guidelines have shown measurement of serum cystatin C ...
Source: Clinical Nephrology - June 25, 2020 Category: Urology & Nephrology Authors: Ichigi M, Nakatani S, Murakami M, Harada Y, Utsumi S, Ogata M, Maehara Y, Ikeda H, Shimada H, Fukunaga M, Narita Y, Saruwatari J, Kondo Y, Ishitsuka Y, Irie T, Kadowaki D, Hirata S Tags: Clin Nephrol Source Type: research

Malignancy-induced lactic acidosis in adult lymphoma 
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Malignancy-induced lactic acidosis in adult lymphoma
. Clin Nephrol. 2020 Jun 26;: Authors: Duriseti P, Moreno Vanegas Y, Jaber BL, Balakrishnan VS, Madias NE Abstract Malignancy-induced lactic acidosis (MILA), a rare paraneoplastic phenomenon, is mostly described with hematologic malignancies (lymphomas and leukemias) but has also been reported with solid tumors. It is a subset of type B lactic acidosis being mediated without evidence of tissue hypoperfusion. Lymphoma-induced lactic acidosis is often considered an oncologic emergency and is associated with an increased risk of mortality and poor pr...
Source: Clinical Nephrology - June 25, 2020 Category: Urology & Nephrology Authors: Duriseti P, Moreno Vanegas Y, Jaber BL, Balakrishnan VS, Madias NE Tags: Clin Nephrol Source Type: research

Efficacy of abatacept treatment for focal segmental glomerulosclerosis and minimal change disease: A systematic review of case reports, case series, and observational studies 
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Efficacy of abatacept treatment for focal segmental glomerulosclerosis and minimal change disease: A systematic review of case reports, case series, and observational studies
. Clin Nephrol. 2020 Jun 26;: Authors: Hansrivijit P, Puthenpura MM, Ghahramani N Abstract INTRODUCTION: The efficacy of abatacept has been demonstrated mainly in case reports, case series, and observational studies with small sample size. With current evidence, it is premature to conclude that abatacept is an effective treatment for nephrotic syndrome. MATERIALS AND METHODS: We searched MEDLINE, SCOPUS, and Cochrane Libra...
Source: Clinical Nephrology - June 25, 2020 Category: Urology & Nephrology Authors: Hansrivijit P, Puthenpura MM, Ghahramani N Tags: Clin Nephrol Source Type: research

Concomitant monoclonal immunoglobulin deposition disease and crystalglobulin-induced nephropathy with a membranoproliferative pattern of glomerular injury 
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We present a case of a patient with acute kidney injury, and a subsequent kidney biopsy notably revealed concurrent monoclonal immunoglobulin deposition disease (MIDD) and crystalglobulin-induced nephropathy secondary to an IgM/κ monoclonal protein that resulted in a membranoproliferative pattern of glomerular injury. The two process were distinctly evident by ultrastructural crystalline and non-crystalline (as seen with cases of more conventional MIDD) deposits in the glomeruli. The paraprotein constituency is novel (IgM/κ) for crystalglobulin-induced nephropathy (prior cases exhibited IgG/κ restriction)...
Source: Clinical Nephrology - June 25, 2020 Category: Urology & Nephrology Authors: Pichler Sekulic S, Negrea L, Pradhan N, Kalahasti P, Kansal S, Sekulic M Tags: Clin Nephrol Source Type: research

An examination of multiple explanations for  secondary hyperparathyroidism
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CONCLUSIONS: The only theory of SHPT that our data support is the tradeoff-in-the-nephron hypothesis. Other theories are not supported.
. PMID: 32567541 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 21, 2020 Category: Urology & Nephrology Authors: Phelps KR, Mason DL Tags: Clin Nephrol Source Type: research

Resolution of IgA and C3 immune deposits in  Staphylococcus infection-associated glomerulonephritis in a kidney transplant recipient
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We present a combined kidney-pancreas transplant patient who developed SAGN due to Staphylococcus aureus bacteremia from an old infected arteriovenous (AV) graft, which occurred after a long period of stable allograft function. Clinical improvement occurred following surgical debridement and appropriate antibiotics with subsequent clearance of bacteremia. However, 3 weeks later he presented with severe acute kidney injury related to rapidly progressive glomerulonephritis. Renal allograft biopsy revealed immune complex glomerulonephritis with predominance of IgA and C3 in subendothelial and mesangial deposits, consistent wi...
Source: Clinical Nephrology - June 21, 2020 Category: Urology & Nephrology Authors: Nguyen N, Chikkalingaiah KM, Walker PD, Wall BM Tags: Clin Nephrol Source Type: research

Risk factors affecting renal function and survival of patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis 
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Risk factors affecting renal function and survival of patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
. Clin Nephrol. 2020 Jun 22;: Authors: Ge Y, Yang G, Yu X, Sun B, Zhang B, Zeng M, Wang N, Mao H, Xing C Abstract OBJECTIVE: To determine the prognostic values of clinical and laboratory features at the time of presentation on renal function and survival of patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. (MPO-ANCA GN). MATERIALS AND METHODS: A total of 119 patients (52 males and 67 females) with M...
Source: Clinical Nephrology - June 21, 2020 Category: Urology & Nephrology Authors: Ge Y, Yang G, Yu X, Sun B, Zhang B, Zeng M, Wang N, Mao H, Xing C Tags: Clin Nephrol Source Type: research

Nomenclature for Kidney Function and Disease: Executive Summary and Glossary From a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.
PMID: 32553097 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 18, 2020 Category: Urology & Nephrology Authors: Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Cheung M, Jadoul M, Winkelmayer WC Tags: Clin Nephrol Source Type: research

COVID-19: Nephrology preparedness checklist.
PMID: 32452756 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 25, 2020 Category: Urology & Nephrology Authors: Geara AS, Neyra JA Tags: Clin Nephrol Source Type: research

Vascular injury and COVID-19-related mortality: What lies below the tip of the iceberg?
PMID: 32452757 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 25, 2020 Category: Urology & Nephrology Authors: Izzedine H, Jhaveri KD, Perazella MA Tags: Clin Nephrol Source Type: research

Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial 
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Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial
. Clin Nephrol. 2020 May 25;: Authors: Nowak KL, Chonchol M, Jovanovich A, You Z, Ambrosius WT, Cho ME, Glasser S, Lash J, Simmons DL, Taylor A, Weiner D, Rastogi A, Oparil S, Supiano MA Abstract AIMS: Arterial stiffness increases with both advancing age and chronic kidney disease (CKD) and may contribute to kidney function decline, but evidence is inconsistent. We hypothesized that greater baseline arterial stiffness (assessed as pulse pressure (PP) and carotid-femoral pulse-wave velocity CFPWV)) was...
Source: Clinical Nephrology - May 24, 2020 Category: Urology & Nephrology Authors: Nowak KL, Chonchol M, Jovanovich A, You Z, Ambrosius WT, Cho ME, Glasser S, Lash J, Simmons DL, Taylor A, Weiner D, Rastogi A, Oparil S, Supiano MA Tags: Clin Nephrol Source Type: research

A generic method for analysis of plasma concentrations 
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A generic method for analysis of plasma concentrations
. Clin Nephrol. 2020 May 08;: Authors: Phelps KR, Gosmanova EO Abstract The purpose of this NephEd contribution is to introduce a generic method for analyzing plasma concentrations ([x]p). The method is applicable to substances that are filtered by glomeruli, reabsorbed or secreted by tubules, and excreted in urine. The equality from which the method follows states that the filtration rate of substance x is the sum of excretion and net reabsorption rates of x (Fx = Ex + TRx). If x is completely ultrafilterable, Fx = GFR[x]p, and [x]p = Ex/GFR + ...
Source: Clinical Nephrology - May 7, 2020 Category: Urology & Nephrology Authors: Phelps KR, Gosmanova EO Tags: Clin Nephrol Source Type: research

Low-dose gabapentin-induced lower extremity edema in a young peritoneal dialysis patient.
PMID: 32352370 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 29, 2020 Category: Urology & Nephrology Authors: Ice A, Naljayan M, Yazdi F, Reisin E Tags: Clin Nephrol Source Type: research

The impact of vascular calcification among dialysis-dependent South African patients: A  5-year follow-up study
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CONCLUSION: There was no significant progression in vascular calcification among Blacks. After adjusting for increased parathyroidectomy rates, there was a greater progression of vascular calcification amongst non-Blacks compared to Blacks.
. PMID: 32352371 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 29, 2020 Category: Urology & Nephrology Authors: Simba K, Borkum M, Strauss N, Basera W, Swanepoel C, Freercks R, Rayner BL Tags: Clin Nephrol Source Type: research