Carotid intima-media thickness in children with  idiopathic nephrotic syndrome: A single center cross-sectional study
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Carotid intima-media thickness in children with idiopathic nephrotic syndrome: A single center cross-sectional study
. Clin Nephrol. 2019 May 13;: Authors: Skrzypczyk P, Kuźma-Mroczkowska E, Kułagowska J, Brzewski M, Okarska-Napierała M, Pańczyk-Tomaszewska M Abstract AIM: Our aim was to assess common carotid artery intima-media thickness (cIMT) in children with idiopathic nephrotic syndrome (INS) and to find relation between cIMT and clinical and biochemical parameters in these patients. MATERIALS AND METHODS: In 50 children with INS we retrospectively evaluated: cIMT ((mm) ...
Source: Clinical Nephrology - May 13, 2019 Category: Urology & Nephrology Authors: Skrzypczyk P, Kuźma-Mroczkowska E, Kułagowska J, Brzewski M, Okarska-Napierała M, Pańczyk-Tomaszewska M Tags: Clin Nephrol Source Type: research

Analysis of circulating lncRNA expression profiles in patients with diabetes mellitus and diabetic nephropathy: Differential expression profile of circulating lncRNA 
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Analysis of circulating lncRNA expression profiles in patients with diabetes mellitus and diabetic nephropathy: Differential expression profile of circulating lncRNA
. Clin Nephrol. 2019 May 13;: Authors: Yang Y, Lv X, Fan Q, Wang X, Xu L, Lu X, Chen T Abstract BACKGROUND: In order to elucidate the epigenetic mechanism and explore new biomarkers for diabetes and diabetic nephropathy, circulating lncRNA and mRNA expression profiles of normal control, diabetes mellitus, and diabetic nephropathy patients were analyzed. MATERIALS AND METHODS: Serum samples from diabetic nephropathy patients (DN), d...
Source: Clinical Nephrology - May 13, 2019 Category: Urology & Nephrology Authors: Yang Y, Lv X, Fan Q, Wang X, Xu L, Lu X, Chen T Tags: Clin Nephrol Source Type: research

A rare case of atypical chronic lymphocytic leukemia presenting as acute kidney injury.
PMID: 31079599 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 13, 2019 Category: Urology & Nephrology Authors: Wen YK Tags: Clin Nephrol Source Type: research

Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease 
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CONCLUSION: Based on the literature reviewed in this manuscript, it is proposed that further research evaluating the efficacy of endothelin antagonists in treatment of cystic kidney disease is warranted. More human studies need to be performed with larger sample sizes. Therefore, the recommendation for treatment is inconclusive at this time.
. PMID: 30990410 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 16, 2019 Category: Urology & Nephrology Authors: Raina R, Chauvin A, Vajapey R, Khare A, Krishnappa V Tags: Clin Nephrol Source Type: research

Recurrent spontaneous hemorrhage in end-stage renal disease.
PMID: 30990411 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 16, 2019 Category: Urology & Nephrology Authors: Vasquez-Rios G, Daher G, Huebner S, Vo TM Tags: Clin Nephrol Source Type: research

Effects of denosumab on hypercalcemia and bone mineral density loss in kidney transplant recipients 
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Effects of denosumab on hypercalcemia and bone mineral density loss in kidney transplant recipients
. Clin Nephrol. 2019 Apr 16;: Authors: Nanmoku K, Shinzato T, Kubo T, Shimizu T, Yagisawa T Abstract BACKGROUND: Hypercalcemia and bone mineral density (BMD) loss are serious problems associated with post-transplant chronic kidney disease-mineral and bone disorder. The present study aimed to clarify the effects of denosumab on hypercalcemia complicated with BMD loss in kidney transplant recipients. MATERIALS AND METHODS: Among 100 consecutive adult kidney transplant recipients, 16 patients with s...
Source: Clinical Nephrology - April 16, 2019 Category: Urology & Nephrology Authors: Nanmoku K, Shinzato T, Kubo T, Shimizu T, Yagisawa T Tags: Clin Nephrol Source Type: research

Kidney recovery in patients discharged to an acute rehabilitation facility with acute kidney injury requiring hemodialysis 
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CONCLUSION: Almost 2/3 of AKI-RRT patients discharged to an affiliated LTACH with ongoing HD need recovered kidney function. Anemia and the number of HD sessions and intradialytic hypotension episodes were associated with kidney recovery. Future studies should focus on developing risk-stratification tools for kidney recovery and determining best practices to promote recovery in this susceptible population.
. PMID: 30990413 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 16, 2019 Category: Urology & Nephrology Authors: McAdams M, Ortiz-Soriano V, Jordan M, Armentrout B, Vasquez-Rios G, Lima F, Sawaya BP, Neyra JA Tags: Clin Nephrol Source Type: research

Cast nephropathy associated with monoclonal immunoglobulin M-secreting mucosa-associated lymphoid tissue B-cell lymphoma 
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Cast nephropathy associated with monoclonal immunoglobulin M-secreting mucosa-associated lymphoid tissue B-cell lymphoma
. Clin Nephrol. 2019 Apr 09;: Authors: Luan H, Wang C, Xing X, Shao L Abstract The kidney is among the various anatomical sites involved in mucosa-associated lymphoid tissue (MALT) lymphoma. A variety of renal pathological types, including membranous glomerulopathy, membranoproliferative glomerulonephritis, crescentic IgA nephropathy, minimal change disease, and cryoglobulinemic glomerulopathy, have been reported in MALT lymphoma patients. However, cast nephropathy is extremely ra...
Source: Clinical Nephrology - April 9, 2019 Category: Urology & Nephrology Authors: Luan H, Wang C, Xing X, Shao L Tags: Clin Nephrol Source Type: research

Probucol for the prevention of contrast-induced acute kidney injury in patients undergoing coronary angiography or percutaneous coronary intervention: A meta-analysis of randomized controlled trials 
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Probucol for the prevention of contrast-induced acute kidney injury in patients undergoing coronary angiography or percutaneous coronary intervention: A meta-analysis of randomized controlled trials
. Clin Nephrol. 2019 Apr 09;: Authors: Xin W, Lin Z, Zhang T, Jia S Abstract BACKGROUND: The results of pilot randomized controlled trials (RCTs) evaluating probucol treatment on the risk of contrast-induced acute kidney injury (CI-AKI) are inconsistent. We aimed to perform a meta-analysis of RCTs to systematically evaluate the influence of probucol on the incidence of CI-AKI. MATERIALS AND METHODS:...
Source: Clinical Nephrology - April 9, 2019 Category: Urology & Nephrology Authors: Xin W, Lin Z, Zhang T, Jia S Tags: Clin Nephrol Source Type: research

Regression of chronic kidney disease in a patient with AL amyloidosis: A case report 
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CONCLUSION: This case shows that renal recovery in AL amyloidosis may be possible and also highlights the importance of continued therapy in order to achieve clonal response and recovery of organ function.
. PMID: 30935458 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Rowland TA, Gillmore J, Bhandari S Tags: Clin Nephrol Source Type: research

When acute kidney injury in the intensive care unit is not acute tubular necrosis: A case report of κ-light chain crystalline tubulopathy
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CONCLUSION: This case describes a rare presentation of κ light chain crystalline tubulopathy and illustrates the value of a comprehensive evaluation for acute kidney injury to enable prompt diagnosis and therapy.
. PMID: 30935459 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Shah N, Rosales I, Smith RN, Berchuck JE, Yee AJ, Tolkoff-Rubin N Tags: Clin Nephrol Source Type: research

Hyponatremia secondary to transient renal salt wasting (TRSW): A not so uncommon observation in the elderly 
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Hyponatremia secondary to transient renal salt wasting (TRSW): A not so uncommon observation in the elderly
. Clin Nephrol. 2019 Apr 02;: Authors: Musch W, Decaux G Abstract AIMS: We attempted to classify 115 consecutive nonedematous hyponatremic patients according to their history and saline responsiveness. We hereby describe 6 out of them presenting a transient renal salt wasting (TRSW) state of unknown origin. MATERIALS AND METHODS: Six patients with an initial SNa of 126 ± 3 mEq/L were included in the study. They were treated with 2 L isotonic saline infusion over 24 hours. The ...
Source: Clinical Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Musch W, Decaux G Tags: Clin Nephrol Source Type: research

Lupus nephritis: A historical appraisal of how  a skin lesion became a kidney disease
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Lupus nephritis: A historical appraisal of how a skin lesion became a kidney disease
. Clin Nephrol. 2019 Mar 22;: Authors: Airy M, Eknoyan G Abstract "Lupus nephritis", a serious complication of systemic lupus erythematosus (SLE), is an entity of recent vintage. The term "lupus", derived from Latin for wolf, was introduced in the Middle Ages to denote nondescript erosive skin lesions which resembled wolf bites that were known theretofore by their Greek name of "herpes esthiomenos", used in the Hippocratic Corpus for the spread of the lesions like a crawling s...
Source: Clinical Nephrology - March 22, 2019 Category: Urology & Nephrology Authors: Airy M, Eknoyan G Tags: Clin Nephrol Source Type: research

Serum bone markers in ROD patients across the spectrum of decreases in GFR: Activin A increases before all other markers 
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Serum bone markers in ROD patients across the spectrum of decreases in GFR: Activin A increases before all other markers
. Clin Nephrol. 2019 Mar 13;: Authors: Lima F, Mawad H, El-Husseini AA, Davenport DL, Malluche HH Abstract INTRODUCTION: Renal osteodystrophy (ROD) develops early in chronic kidney disease (CKD) and progresses with loss of kidney function. While intact parathyroid hormone (PTH), 1,25-dihydroxyvitamin D3 (1,25D), and fibroblast growth factor-23 (FGF-23) levels are usually considered the primary abnormalities in ROD development, the role of serum activin A elevations in CKD and its ...
Source: Clinical Nephrology - March 13, 2019 Category: Urology & Nephrology Authors: Lima F, Mawad H, El-Husseini AA, Davenport DL, Malluche HH Tags: Clin Nephrol Source Type: research

The association of nephrolithiasis with prescription opioid use 
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The association of nephrolithiasis with prescription opioid use
. Clin Nephrol. 2019 Mar 13;: Authors: Pais VM, Sites BD Abstract OBJECTIVE: To characterize opioid utilization among those with nephrolithiasis in a national cohort. MATERIALS AND METHODS: We performed cross sectional analysis of participants in the Medical Expenditure Panel Surveys during 2008 - 2014. Sample weights were employed for analysis of complex survey design. Those reporting occurrence of "renal or ureteral calculus" during the survey period represented the cohort of stone formers (SFs). Receipt of op...
Source: Clinical Nephrology - March 13, 2019 Category: Urology & Nephrology Authors: Pais VM, Sites BD Tags: Clin Nephrol Source Type: research

Association of baseline histopathology and kidney donor risk index with graft outcomes in  deceased donor kidney transplantation
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Association of baseline histopathology and kidney donor risk index with graft outcomes in deceased donor kidney transplantation
. Clin Nephrol. 2019 Mar 08;: Authors: Park KS, Park SJ, Park H, Kim M, Park J, Chung HC, Cho HR, Lee JS Abstract BACKGROUND: Donor organ quality is a key determinant of graft outcomes in deceased donor kidney transplantation (DDKT). The predictive values of baseline histopathology and several clinical scoring systems for long-term graft outcomes have been evaluated, but the results remain controversial. MATERIALS AND METHODS: We screened 167 patients who underwen...
Source: Clinical Nephrology - March 8, 2019 Category: Urology & Nephrology Authors: Park KS, Park SJ, Park H, Kim M, Park J, Chung HC, Cho HR, Lee JS Tags: Clin Nephrol Source Type: research

Comparison of clinical assessment and multifrequency bioimpedance analysis as methods of estimating volume status in peritoneal dialysis patients - A single-center experience 
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Comparison of clinical assessment and multifrequency bioimpedance analysis as methods of estimating volume status in peritoneal dialysis patients - A single-center experience
. Clin Nephrol. 2019 Mar 08;: Authors: Vujicic B, Dorcic G, Babic V, Rundic A, Devcic B, Simac DV, Zaputovic L, Racki S Abstract INTRODUCTION: Clinical assessment (CA) is frequently used for the evaluation of volume status in peritoneal dialysis (PD) patients despite its subjectivity. Multiple-frequency bioelectrical impedance analysis (MF-BIA) is objective, accurate, and quick, proving to be a promising technique for measuring...
Source: Clinical Nephrology - March 8, 2019 Category: Urology & Nephrology Authors: Vujicic B, Dorcic G, Babic V, Rundic A, Devcic B, Simac DV, Zaputovic L, Racki S Tags: Clin Nephrol Source Type: research

Retraction of the original article "Persian version of thirst distress scale (TDS) in patients on hemodialysis: Factor structure and psychometric properties.
Retraction of the original article "Persian version of thirst distress scale (TDS) in patients on hemodialysis: Factor structure and psychometric properties. Clin Nephrol. 2019 Mar 05;: Authors: Jafari H Abstract Retraction of the original article "Persian version of thirst distress scale (TDS) in patients on hemodialysis: Factor structure and psychometric properties" by Amir Hossein Goudarzian, Azar Jafari, Belgüzar Kara, Mozhgan Taebi, and Hedayat Jafari in Clinical Nephrology,Vol 91 - No. 2/2019, pp 72 - 78. doi: 10.5414/CN109406: Dear Editor in Chief, When our article was publi...
Source: Clinical Nephrology - March 5, 2019 Category: Urology & Nephrology Authors: Jafari H Tags: Clin Nephrol Source Type: research

Long-term low-dose maintenance glucocorticoids in ANCA vasculitis.
Abstract PMID: 30821684 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 1, 2019 Category: Urology & Nephrology Authors: Rodrigues JC, Walsh M Tags: Clin Nephrol Source Type: research

Mitigating risk of glucocorticoid toxicity during the maintenance phase of ANCA vasculitis treatment.
Abstract PMID: 30821685 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 1, 2019 Category: Urology & Nephrology Authors: Singh HK, Pendergraft Iii WF Tags: Clin Nephrol Source Type: research

Long-term low-dose corticosteroids for maintenance of remission in ANCA vasculitis: Friend or foe?
Abstract PMID: 30821686 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 1, 2019 Category: Urology & Nephrology Authors: O'Shaughnessy MM Tags: Clin Nephrol Source Type: research

Comparison of different equations for estimated glomerular filtration rate in Han Chinese patients with chronic kidney disease.
CONCLUSION: For assessment of renal function, the EPI_Cr equation performed the best and remained an acceptable alternative to the EPI_Cr_CysC equation in the absence of cystatin C.
. PMID: 30802202 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: Yan C, Wu B, Zeng M, Yang G, Ouyang C, Zhang B, Wang N, Xing C, Mao H Tags: Clin Nephrol Source Type: research

The efficacy and safety of retroperitoneoscopic renal pedicle ligation of lymphatic disconnection versus open surgery in the treatment of chyluria: A systematic review and meta-analysis 
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CONCLUSION: Compared with OS, RRPLD has several advantages such as shorter operative time, less intraoperative blood loss, and lower incidence of complications. Thus, it may be an efficacious and safe therapeutic modality for chyluria.
. PMID: 30802203 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: You W, Luan B, Cheng T, Rao H, Yuan D, Wang W, Su J, Wang Y, Sun Z, Zhong W, Zhu J Tags: Clin Nephrol Source Type: research

Ferumoxytol for iron deficiency anemia in  patients undergoing hemodialysis. The FACT randomized controlled trial
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Ferumoxytol for iron deficiency anemia in patients undergoing hemodialysis. The FACT randomized controlled trial
. Clin Nephrol. 2019 Feb 25;: Authors: Macdougall IC, Strauss WE, Dahl NV, Bernard K, Li Z Abstract BACKGROUND: Patients with chronic kidney disease (CKD) undergoing dialysis often require intravenous iron for iron deficiency anemia (IDA). MATERIALS AND METHODS: The Ferumoxytol for Anemia of CKD Trial (FACT), a randomized, multicenter, open-label, phase 4 study, compared the long-term safety and efficacy of ferumoxytol with iron sucrose for the treatment of IDA in patients ...
Source: Clinical Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: Macdougall IC, Strauss WE, Dahl NV, Bernard K, Li Z Tags: Clin Nephrol Source Type: research

What is the best fluid type for management of patients with an identified acute kidney injury? 
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What is the best fluid type for management of patients with an identified acute kidney injury?
. Clin Nephrol. 2019 Feb 25;: Authors: Bulman J, Chacko B Abstract Acute kidney injury and fluid management are linked in a close and complex relationship. The exact nature of this relationship and the role of differing fluid composition in the development of acute kidney injury has been studied within several populations. Several recent large studies have highlighted that we should be judicious in our approach and aware of the risks and benefits different fluid management regimens pose to those at risk of...
Source: Clinical Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: Bulman J, Chacko B Tags: Clin Nephrol Source Type: research

Acute kidney injury incidence in patients with hematological malignancy treated with meropenem and vancomycin for febrile neutropenia.
Abstract PMID: 30738491 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 10, 2019 Category: Urology & Nephrology Authors: Kobayashi S, Yasu T, Momo K Tags: Clin Nephrol Source Type: research

Burden, access, and disparities in kidney disease.
Abstract Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight that many countries still lack ac...
Source: Clinical Nephrology - February 1, 2019 Category: Urology & Nephrology Authors: Crews DC, Bello AK, Saadi G, For The World Kidney Day Steering Committee Tags: Clin Nephrol Source Type: research

Maintenance therapy for lupus nephritis with mycophenolate mofetil or azathioprine. A meta-analysis 
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CONCLUSION: MMF seems more effective than AZA as maintenance therapy for LN although the differences did not reach statistical significance. Furthermore, the MMF group incurred lower risk of leukopenia than AZA. However, more RCTs are needed to confirm the conclusion.
. PMID: 30686286 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 28, 2019 Category: Urology & Nephrology Authors: Deng J, Xie H, Zhu L, Luo L, Xie H Tags: Clin Nephrol Source Type: research

Impaired cognition in hemodialysis patients: The Montreal Cognitive Assessment (MoCA) and important clues for testing 
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Impaired cognition in hemodialysis patients: The Montreal Cognitive Assessment (MoCA) and important clues for testing
. Clin Nephrol. 2019 Jan 28;: Authors: Erken E, Altunoren O, Senel ME, Tuncel D, Yilmaz T, Ganidagli SE, Demircioglu D, Gungor O Abstract BACKGROUND: Cognitive impairment is common among hemodialysis (HD) patients and is associated with poor treatment compliance and mortality. The aim of this study is to evaluate relatively young HD patients with less comorbidities using the Montreal Cognitive Assessment (MoCA) and identify clues for earlier detection of cognitive impairment with the...
Source: Clinical Nephrology - January 28, 2019 Category: Urology & Nephrology Authors: Erken E, Altunoren O, Senel ME, Tuncel D, Yilmaz T, Ganidagli SE, Demircioglu D, Gungor O Tags: Clin Nephrol Source Type: research

The importance of correct estimation of renal function for drug treatment in hospitalized elderly patients, especially women: A  prospective observational study
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DISCUSSION: The C&Gcc, C&Guc, and BIS2 equations gave the best estimate of kidney function in relation to mGFR for drug dosing in the elderly. The eGFR methods showed significantly higher clearance than mGFR, C&Gcc, C&Guc, and BIS2. RRDs that needed dose adjustment were common in this geriatric population. If the eGFR formulas (MDRD4, CKD-EPI, and CAPA) are used instead of C&Gcc, C&Guc, and BIS2, higher and potentially more risky doses of RRDs may be administered to geriatric patients over 75 years, women in particular.
. PMID: 30686288 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 28, 2019 Category: Urology & Nephrology Authors: Helldén A, Bergman U, Odar-Cederlöf I Tags: Clin Nephrol Source Type: research

Familial interstitial nephritis: 42 years from case series to genetic diagnosis.
Abstract PMID: 30686289 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 28, 2019 Category: Urology & Nephrology Authors: Clissold RL, Bingham C, Shaw-Smith C Tags: Clin Nephrol Source Type: research

Risk factors affecting arteriovenous access patency in nocturnal home hemodialysis patients 
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CONCLUSION: AV accesses appear to have a finite duration of functionality, with history of renal transplant being a protective factor, and more dysfunction was found in AV grafts. Access-related factors account for frequent dysfunction rather than patient or HHD factors. The role of access surveillance, especially in patients having high risk of dysfunction, remains to be investigated.
. PMID: 30663973 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 21, 2019 Category: Urology & Nephrology Authors: Mok MMY, Chan CT Tags: Clin Nephrol Source Type: research

Patients' perspectives on dialysis decision-making and end-of-life care 
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CONCLUSION: Most dialysis patients wish to have more frequent discussions about their disease, prognosis, and EoLC planning. Findings from this study can inform the design of future interventions.
. PMID: 30663974 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 21, 2019 Category: Urology & Nephrology Authors: Saeed F, Sardar MA, Davison SN, Murad H, Duberstein PR, Quill TE Tags: Clin Nephrol Source Type: research

Changes in primary glomerulonephritis in Singapore over four decades 
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Changes in primary glomerulonephritis in Singapore over four decades
. Clin Nephrol. 2019 Jan 21;: Authors: Woo KT, Chan CM, Lim C, Choo J, Chin YM, Teng WL, Loh AHL, Choong HL, Tan HK, Wong KS, Lee GSL, Lee EJC, Fook-Chong S, Tan PH, Foo M Abstract This review of 3,289 native kidney biopsies over the past four decades in Singapore documents the changing pattern of biopsy-proven glomerulonephritis (GN)from that of a third world country to that of a developed nation. In the 1st decade, mesangial proliferative GN was the most common form of primary GN, similar to the Asian region. In the 2nd decade, t...
Source: Clinical Nephrology - January 21, 2019 Category: Urology & Nephrology Authors: Woo KT, Chan CM, Lim C, Choo J, Chin YM, Teng WL, Loh AHL, Choong HL, Tan HK, Wong KS, Lee GSL, Lee EJC, Fook-Chong S, Tan PH, Foo M Tags: Clin Nephrol Source Type: research

Remission of nephrotic syndrome after resolution of renal artery stenosis in a patient with a single functional kidney.
Abstract PMID: 30663976 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 21, 2019 Category: Urology & Nephrology Authors: Schiefer J, Chatzikyrkou C, Mertens PR, Liakopoulos V Tags: Clin Nephrol Source Type: research

Treatment of iron deficiency in patients with chronic kidney disease: A prospective observational study of iron isomaltoside (NIMO Scandinavia) 
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CONCLUSION: Iron isomaltoside shows a good effectiveness and safety profile in predialysis CKD patients. However, some patients did not receive adequate iron doses to allow for optimal correction of their iron deficiency anemia.
. PMID: 30614439 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 7, 2019 Category: Urology & Nephrology Authors: Jensen G, Gøransson LG, Fernström A, Furuland H, Christensen JH Tags: Clin Nephrol Source Type: research

The clinical and pathological features of adefovir dipivoxil-related renal impairment 
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CONCLUSION: Nephrotoxicity developed in patients undergoing long-term ADV treatment and was partially reversible after drug cessation. Tubulointerstitial lesions and heteromorphic mitochondria were the predominant pathological changes. Patients with ADV-induced renal impairment should replace ADV with other antiviral agents other than tenofovir.
. PMID: 30614440 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 7, 2019 Category: Urology & Nephrology Authors: Lv Y, Li X, Liang S, Liang D, Xu F, Zhu X, Zeng C Tags: Clin Nephrol Source Type: research

Telavancin-associated acute kidney injury 
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We present a case of a 47-year-old man with methicillin-resistant Staphylococcus aureus bacteremia treated with telavancin, who developed AKI after 5 weeks of intravenous therapy. Acute tubular injury with lysosomal proliferation and acute interstitial nephritis were observed on kidney biopsy. To our knowledge, this is the first reported case of AKI due to telavancin that has documented kidney histopathology.
. PMID: 30614441 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 7, 2019 Category: Urology & Nephrology Authors: Cavanaugh C, Moeckel GW, Perazella MA Tags: Clin Nephrol Source Type: research

Acute kidney injury due to Djembe drumming.
Y, Bover J Abstract PMID: 30574861 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 21, 2018 Category: Urology & Nephrology Authors: Molina-Andújar A, Del Carpio J, García-Herrera A, Arce Y, Bover J Tags: Clin Nephrol Source Type: research

Nephrotic state substantially enhances apparent mycophenolic acid clearance 
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Nephrotic state substantially enhances apparent mycophenolic acid clearance
. Clin Nephrol. 2018 Dec 21;: Authors: Kirpalani A, Rothfels L, Sharma AP, Rodriguez Cuellar C, Filler G Abstract BACKGROUND: Several factors may decrease plasma protein binding of mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), and potentially enhance its clearance. It is unclear if MMF dose adjustments are required for the treatment of steroid-resistant nephrotic syndrome (SRNS). Therapeutic drug monitoring of MPA levels is not widely utilized in the treatment of steroid-resistant nephrotic syn...
Source: Clinical Nephrology - December 21, 2018 Category: Urology & Nephrology Authors: Kirpalani A, Rothfels L, Sharma AP, Rodriguez Cuellar C, Filler G Tags: Clin Nephrol Source Type: research

Comment on "Vitamin E supplementation improves high-density lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis" by Mune et al. Clinical Nephrology DOI 10.5414/CN109197 e-pub: April 9, 2018.
Comment on "Vitamin E supplementation improves high-density lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis" by Mune et al. Clinical Nephrology DOI 10.5414/CN109197 e-pub: April 9, 2018. Clin Nephrol. 2018 Dec 19;: Authors: Ravarotto V, Simioni F, Pagnin E, Calò LA Abstract PMID: 30563608 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 19, 2018 Category: Urology & Nephrology Authors: Ravarotto V, Simioni F, Pagnin E, Calò LA Tags: Clin Nephrol Source Type: research

Helping patients and the profession: Nephrology-oriented point-of-care ultrasound program for internal medicine residents.
Abstract PMID: 30563609 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 19, 2018 Category: Urology & Nephrology Authors: Koratala A, Bhattacharya D, Kazory A Tags: Clin Nephrol Source Type: research

External validation of prediction models for mortality in an incident dialysis population 
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CONCLUSION: The survival probability model by Hemke et al. [6] may be preferred for mortality prediction in incident dialysis patients. The Liu index could be used to predict hospital admissions in the same population. Available models demonstrated only modest performance in predicting either outcome. Therefore, alternative models need to be developed.
. PMID: 30526813 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 11, 2018 Category: Urology & Nephrology Authors: Mavrakanas TA, Asfour K, Vasilevsky M, Barré PE, Alam A Tags: Clin Nephrol Source Type: research

Persian version of thirst distress scale (TDS) in patients on hemodialysis: Factor structure and psychometric properties 
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Persian version of thirst distress scale (TDS) in patients on hemodialysis: Factor structure and psychometric properties
. Clin Nephrol. 2018 Dec 11;: Authors: Goudarzian AH, Jafari A, Kara B, Taebi M, Jafari H Abstract BACKGROUND: Patients on hemodialysis can experience thirst distress. However, there is no valid and reliable Persian instrument to measure this condition in such patients. The present study aims to determine the psychometric properties of the Persian version of the thirst distress scale (TDS) for patients on hemodialysis. MATERIALS AND METHODS: Our sample consisted of 142 hemodi...
Source: Clinical Nephrology - December 11, 2018 Category: Urology & Nephrology Authors: Goudarzian AH, Jafari A, Kara B, Taebi M, Jafari H Tags: Clin Nephrol Source Type: research

Hemodynamic effects of hemodialyzer pump speed on arteriovenous fistulas 
.
Hemodynamic effects of hemodialyzer pump speed on arteriovenous fistulas
. Clin Nephrol. 2018 Dec 11;: Authors: Hammes M, McGill RL, Basu A, Blicharski T, Delaney K Abstract AIM: Arteriovenous fistulas (AVF) are the optimal vascular access for hemodialysis although many fistulas fail. The impetus to increase hemodialyzer blood flow (QB) in order to maximize solute clearances may be counterbalanced if AVF suffer adverse hemodynamic effects from accelerated pump flows. The optimal QB to maintain adequate hemodialysis without potentially contributing to AVF dysfunction is unknown. The aim of this study...
Source: Clinical Nephrology - December 11, 2018 Category: Urology & Nephrology Authors: Hammes M, McGill RL, Basu A, Blicharski T, Delaney K Tags: Clin Nephrol Source Type: research

BK virus nephropathy and multiorgan involvement in a child with heart transplantation 
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BK virus nephropathy and multiorgan involvement in a child with heart transplantation
. Clin Nephrol. 2018 Dec 11;: Authors: Lee Y, Kim YJ, Cho H Abstract BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Before ...
Source: Clinical Nephrology - December 11, 2018 Category: Urology & Nephrology Authors: Lee Y, Kim YJ, Cho H Tags: Clin Nephrol Source Type: research

Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy 
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We report the experience of treating patients with C3GN in association with monoclonal gammopathy with corticosteroid at a single center. MATERIALS AND METHODS: Corticosteroid therapy alone was used to treat 6 patients with C3GN who were also found to have monoclonal gammopathy at the time of presentation. RESULTS: Median age of this cohort was 65 years. Median estimated glomerular filtration rate (eGFR) by MDRD equation was 31.6 mL/min/1.73m2 at presentation. After a median duration of follow-up of 23.5 months, all patients showed improvement in proteinuria: median proteinuria reduced from 2.3 to 0.5 g/d. Four o...
Source: Clinical Nephrology - November 26, 2018 Category: Urology & Nephrology Authors: Sathick IJ, Zand L, Nasr SH, Leung N Tags: Clin Nephrol Source Type: research

Risk factors for graft loss in kidney transplant recipients with g3 glomerulitis: A single-center experience 
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CONCLUSION: Severe glomerulitis was associated with a high prevalence of TG and graft loss at 4 years. Live donor status, kidney function (Scr), and tubular injury (t- and ct-scores) were independently associated with graft loss. Interventional mechanistic clinical trials are needed to better understand the pathogenesis and outcomes of g3 glomerulitis.
. PMID: 30474594 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 26, 2018 Category: Urology & Nephrology Authors: Aziz F, Parajuli S, Mohamed M, Garg N, Muth B, Mandelbrot D, Ellis T, Zhong W, Djamali A Tags: Clin Nephrol Source Type: research

A case of membranous nephropathy characterized by atypical distribution of  phospholipase A2 receptor
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A case of membranous nephropathy characterized by atypical distribution of phospholipase A2 receptor
. Clin Nephrol. 2018 Nov 26;: Authors: Hyodo T, Saito K, Kono K, Nishi S, Itoh T, Hara S Abstract A 77-year-old man was referred to our hospital with persistent proteinuria and progressive lower leg edema. Past history was unremarkable except for hypertension. Autoimmune diseases, infections, and malignancies were excluded based on clinical and laboratory test results. Renal biopsy specimens showed membranous nephropathy with segmental distribution of spikes and bubbling appearance. Double conto...
Source: Clinical Nephrology - November 26, 2018 Category: Urology & Nephrology Authors: Hyodo T, Saito K, Kono K, Nishi S, Itoh T, Hara S Tags: Clin Nephrol Source Type: research

Identification of new α-galactosidase A mutation responsible for Fabry disease: A case report.
Identification of new α-galactosidase A mutation responsible for Fabry disease: A case report. Clin Nephrol. 2018 Nov 26;: Authors: Battaglia Y, Scalia S, Rinaldi R, Storari A, Mignani R, Russo D, Duro G Abstract PMID: 30474596 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 26, 2018 Category: Urology & Nephrology Authors: Battaglia Y, Scalia S, Rinaldi R, Storari A, Mignani R, Russo D, Duro G Tags: Clin Nephrol Source Type: research