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Gram-negative bloodstream infections in hemodialysis patients: A retrospective study 
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CONCLUSION: In a cohort of HD patients with BSI, no significant differences were found between Gram-negative and Gram-positive BSIs, besides source of infection. A urinary or abdominal source strongly suggests a Gram-negative pathogen. Otherwise, patient's characteristics, clinical presentation, and previous cultures, all cannot accurately predict the causative pathogen of BSI, and broad-spectrum antibiotics should be used empirically.
. PMID: 29648529 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 12, 2018 Category: Urology & Nephrology Authors: Shimon O, Green H, Eliakim-Raz N, Rozen-Zvi B, Ben-Zvi H, Zohar I, Bishara J, Yahav D Tags: Clin Nephrol Source Type: research

Clinical and histological features of antineutrophil cytoplasmic antibody-associated vasculitis related to antithyroid drugs 
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Clinical and histological features of antineutrophil cytoplasmic antibody-associated vasculitis related to antithyroid drugs
. Clin Nephrol. 2018 Apr 12;: Authors: Hasegawa J, Hoshino J, Sekine A, Hayami N, Suwabe T, Sumida K, Mise K, Ueno T, Yamanouchi M, Hazue R, Sawa N, Ohashi K, Fujii T, Takaichi K, Ubara Y Abstract BACKGROUND: Antithyroid drugs such as propylthiouracil and methimazole have been reported to cause antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but little is known about long-term outcomes. MATERIALS AND METHODS: We identified AAV patients who underwen...
Source: Clinical Nephrology - April 12, 2018 Category: Urology & Nephrology Authors: Hasegawa J, Hoshino J, Sekine A, Hayami N, Suwabe T, Sumida K, Mise K, Ueno T, Yamanouchi M, Hazue R, Sawa N, Ohashi K, Fujii T, Takaichi K, Ubara Y Tags: Clin Nephrol Source Type: research

Controversies in Clinical Nephrology: Optimizing renal replacement therapy deliverables through multidisciplinary work in the intensive care unit.
Abstract Two essential elements to provide effective RRT to critically ill patients with AKI in the ICU are: 1) the multidisciplinary interplay among intensivists, nephrologists, pharmacists, nurses, nutritionists, and other key members of the acute-care team for personalized therapy (i.e., RRT candidacy, timing of RRT initiation, RRT goals for solute control, RRT goals for fluid removal/regulation, renal recovery evaluation, RRT de-escalation, etc.) and 2) the iterative assessment and adjustment of RRT goals according to the clinical status of the patient. Therefore, the vehicle for effective RRT in the ICU requi...
Source: Clinical Nephrology - April 10, 2018 Category: Urology & Nephrology Authors: Neyra JA, Goldstein SL Tags: Clin Nephrol Source Type: research

Controversies in Clinical Nephrology: Challenges of performing renal replacement therapy in the intensive care unit - The nephrologist perspective.
sky P Abstract Nephrologists play a key role in the management of the critically ill patient requiring CRRT. Having clear organizational guidelines, open collaboration, and cross-enrichment is the approach most likely to lead to the best patient outcomes. PMID: 29633701 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 10, 2018 Category: Urology & Nephrology Authors: Cerdá J, Tolwani A, Palevsky P Tags: Clin Nephrol Source Type: research

Controversies in Clinical Nephrology: Challenges of performing renal replacement therapy in the intensive care unit - The intensivist perspective.
Abstract In 2017, models of care in the best institutions around the world are no longer at the extremes discussed above. In the UK, intensivists with specialist renal interest and, not uncommonly, joint specialist training in nephrology are able to provide clinical expertise, devise more flexible RRT protocols, and provide liaison with specialist renal services without compromising speed and integration of RRT into integrated organ support. Similarly, in nephrology-led care, renal specialists are becoming more subspecialized, with acute nephrology physicians and nurses having a much greater presence in the ICU an...
Source: Clinical Nephrology - April 10, 2018 Category: Urology & Nephrology Authors: Prowle JR Tags: Clin Nephrol Source Type: research

Proteinuria: A presenting manifestation of  mirror syndrome in pregnancy
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Proteinuria: A presenting manifestation of mirror syndrome in pregnancy
. Clin Nephrol. 2018 Apr 10;: Authors: Banoth P, Chaudhary K Abstract Hypertension and proteinuria in pregnant women are most commonly signs of preeclampsia which develops after 20 weeks of gestation. There are rare incidences of uncontrolled hypertension and nephrotic range proteinuria even in the first trimester of pregnancy which can be indicators of severe underlying fetal and placental abnormalities rather than preeclampsia. A G2P0 30-year-old Caucasian woman was admitted to University Hospital for the incidental ...
Source: Clinical Nephrology - April 10, 2018 Category: Urology & Nephrology Authors: Banoth P, Chaudhary K Tags: Clin Nephrol Source Type: research

Diastolic blood pressure variability in 24 hour-ABPM and outcomes of chronic kidney disease 
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CONCLUSION: These findings suggest that DBP variability in 24-hour ABPM may be a good prognostic factor for the outcomes of CKD. Further studies are needed to determine the impact of 24-hour ABPM BPV on CKD progression and its differences from VVV.
. PMID: 29633704 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 10, 2018 Category: Urology & Nephrology Authors: Sahutoglu T, Sakaci T Tags: Clin Nephrol Source Type: research

Early postoperative measurement of fibroblast growth factor 23 predicts severe acute kidney injury in infants after cardiac surgery 
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CONCLUSION: Early measurement of FGF23 has predictive ability in infants who develop sAKI after CS with cardiopulmonary bypass.
. PMID: 29633705 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 10, 2018 Category: Urology & Nephrology Authors: Volovelsky O, Gist KM, Terrell TC, Bennett MR, Cooper DS, Alten JA, Goldstein SL Tags: Clin Nephrol Source Type: research

Vitamin E supplementation improves high-densitiy lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis 
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CONCLUSION: In ESKD patients undergoing hemodialysis, vitamin E supplementation significantly improved the HDL function of CEC and, in diabetic patients, endothelial function. These effects were independent of Hp phenotype.
. PMID: 29628022 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 9, 2018 Category: Urology & Nephrology Authors: Mune M, Uto-Kondo H, Iteya I, Fujii Y, Ikeda S, Ikewaki K Tags: Clin Nephrol Source Type: research

Antinephritis-associated plasmin receptor (NAPlr) antibody-positive glomerulonephritis caused by Aggregatibacter actinomycetemcomitans bacteremia: a case report.
We report the case of a 64-year-old man who experienced repeated fever for several months and presented with progressively-deteriorating renal function. He had previously undergone aortic valve replacement. Aggregatibacter actinomycetemcomitans, a component of the oral flora, was detected in a blood culture. Renal biopsy showed diffuse proliferative glomerulonephritis. Immunofluorescence staining of the kidney specimen was positive for immunoglobulins, complements, and NAPlr. The patient was diagnosed with infectious endocarditis and IRGN. Six weeks of intravenous antibiotic therapy improved the patient's clinical conditio...
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Komaru Y, Ishioka K, Oda T, Ohtake T, Kobayashi S Tags: Clin Nephrol Source Type: research

Fibrillary glomerulonephritis in an HIV patient without concurrent hepatitis C infection: Case  report and review of the literature
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Fibrillary glomerulonephritis in an HIV patient without concurrent hepatitis C infection: Case report and review of the literature
. Clin Nephrol. 2018 Mar 26;: Authors: Zhang L, Carson JM, Lucia MS Abstract The most common renal disease associated with human immunodeficiency virus infection (HIV) is HIV-associated nephropathy (HIVAN), especially in the African American patient population. However, various patterns of glomerulonephritis (GN) are not uncommon, collectively accounting for nearly half of the renal biopsies performed in HIV patients. Most GNs that occur in HIV patients are immune c...
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Zhang L, Carson JM, Lucia MS Tags: Clin Nephrol Source Type: research

Variability of serum phosphorus and its  association with mortality among hemodialysis patients
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CONCLUSION: Higher phosphorus CV was independently correlated with all-cause and CVD mortality. Low phosphorus variability with on-target levels resulted in decreased patient mortality. Thus, stable serum phosphorus levels may improve survival in MHD patients.
. PMID: 29578398 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Zhu M, Dou L, Zhu M, Liu S, Zhan Y, Lu J, Ni Z, Qian J, Cai H, Zhang W Tags: Clin Nephrol Source Type: research

Mini-review of kidney disease following hematopoietic stem cell transplant 
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Mini-review of kidney disease following hematopoietic stem cell transplant
. Clin Nephrol. 2018 Mar 26;: Authors: Sedhom R, Sedhom D, Jaimes E Abstract Advancements in hematopoietic cell transplantation (HCT) have broadened indications for its use and resulted in more long-term survivors. Stem cell transplantation is associated with several well-known toxicities, although renal complications are not well defined. Acute and chronic kidney disease remains a common complication following transplantation itself. Incidence and risk factors for the development of chronic kidney disease (CKD) is less well ...
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Sedhom R, Sedhom D, Jaimes E Tags: Clin Nephrol Source Type: research

Incidence and timing of inadvertent nephrostomy catheter displacement in  patients with ureteral obstruction
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CONCLUSION: There were no significant differences in the nephrostomy catheter displacement-free survival rates between the two types of catheters. Regardless of the type of catheter, our results indicated that careful handling and guiding during catheter placement are important for all patients because of the high risk of inadvertent events.
. PMID: 29578400 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Niwa N, Matsumoto K, Kikuchi E, Yazawa S, Takeda T, Morita S, Kosaka T, Shinoda K, Mizuno R, Shinojima T, Asanuma H, Oya M Tags: Clin Nephrol Source Type: research

Association between preoperative renin-angiotensin system inhibitor use and postoperative acute kidney injury risk in patients with hypertension 
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Association between preoperative renin-angiotensin system inhibitor use and postoperative acute kidney injury risk in patients with hypertension
. Clin Nephrol. 2018 Mar 26;: Authors: Xu N, Long Q, He T, Liu X, Dai H, Lu Y, Wen J, Wu Q, Yuan H Abstract PURPOSE: To determine whether preoperative renin-angiotensin system (RAS) inhibitor use within 7 days of noncardiac surgery is associated with a lower incidence of postoperative acute kidney injury (AKI) in hypertensive patients. MATERIALS AND METHODS: We retrospectively analyzed 12,545 hypertensive patients undergoing noncardiac surgery at the T...
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Xu N, Long Q, He T, Liu X, Dai H, Lu Y, Wen J, Wu Q, Yuan H Tags: Clin Nephrol Source Type: research

Chemotherapeutic agents eligible for prior dosing in pancreatic cancer patients requiring hemodialysis: a systematic review 
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CONCLUSION: This work supports the application of dialyzable chemotherapeutic agents in patients with PDAC in standard dose when HD is performed shortly after the infusion.
. PMID: 29578402 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Hann A, Nosalski E, Hermann PC, Egger J, Seufferlein T, Keller F Tags: Clin Nephrol Source Type: research

Patient-reported outcomes (PROs) argue against the limited use of peritoneal dialysis in  end-stage renal disease
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CONCLUSION: This single-center cross-section with a modest number of patients but an almost 100% patient response shows that having 40% of patients on PD is possible with excellent results in terms of patient-reported outcomes. A structured patient education with attention to personal needs of patients, an adequate infrastructure for PD, and a dedicated team with ongoing patient support are key factors. Sharing best practices may help to slow down or even reverse the decline of PD, which is a pity both for patients and society.
. PMID: 29578403 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: de Fijter CWH, van Diepen ATN, Amiri F, Dekker FW, Krediet RT Tags: Clin Nephrol Source Type: research

Priapism and hemodialysis: Case report and literature review 
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CONCLUSION: Priapism is a rarely reported complication of dialysis in adult patients and has not been described in pediatric dialysis patients. The etiology remains unclear but is hypothesized to be multifactorial including heparin-associated effects and epoetin administration. In our patients, commonality between the two included presumed high androgen levels (given age) and borderline to high hemoglobin levels in patients receiving epoetin alfa. This in combination with prior studies highlights the possible role epoetin administration may play. The role of heparin remains a possibility but is unclear. Further studies are...
Source: Clinical Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Shih WV, Wong C Tags: Clin Nephrol Source Type: research

Renovascular disease: Is there still a role for revascularization? 
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This article reviews the current knowledge on advantages and limitations of interventional techniques in the management of patients with atherosclerotic renovascular disease.
. PMID: 29493505 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 1, 2018 Category: Urology & Nephrology Authors: Campese V, Adenuga G Tags: Clin Nephrol Source Type: research

Risk factors of peritonitis during early  peritoneal dialysis in patients with 
ANCA-associated systemic vasculitis
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This study investigated the risk factors of peritonitis during early peritoneal dialysis for renal failure in patients with antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (AASV). This study enrolled hospitalized AASV patients with renal failure who underwent peritoneal dialysis at the Department of Nephrology of our hospital between 2008 and 2015. The primary aim of this study was to perform a retrospective analysis to characterize peritonitis during the early period (≤ 8 weeks) of dialysis, and to compare the differences in initial clinical manifestations, vasculitis activity, immun...
Source: Clinical Nephrology - February 21, 2018 Category: Urology & Nephrology Authors: Liu G, Chen J Tags: Clin Nephrol Source Type: research

Hepcidin and proinflammatory markers in  children with chronic kidney disease: A case-control study
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CONCLUSION: A positive correlation between hepcidin and other inflammatory biomarkers in non-dialyzed, iron- and EPO-naïve pediatric CKD patients suggests a role of these markers in higher hepcidin production and its contribution to iron-restricted erythropoiesis across the spectrum of CKD. Median hepcidin levels were highest in those with impaired iron trafficking, followed by those with no iron deficiency, followed by those with absolute iron deficiency, suggesting that in an iron-replete state, high hepcidin levels inhibit iron absorption from the gut and release from iron storing cells, thus restricting erythropoi...
Source: Clinical Nephrology - February 16, 2018 Category: Urology & Nephrology Authors: Goyal KK, Saha A, Sahi PK, Kaur M, Dubey NK, Goyal P, Upadhayay AD Tags: Clin Nephrol Source Type: research

Uremia: A historical reappraisal of what happened 
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Uremia: A historical reappraisal of what happened
. Clin Nephrol. 2018 Feb 16;: Authors: Raghavan R, Eknoyan G Abstract Urea was identified as a urinary salt in 1662 and was the first organic bodily product to be synthesized in vitro in 1828. This heralded the end of an era that defined disease as an imbalance between vital life forces, and catalyzed the merging of organic chemical sciences into clinical medicine. The term urée (urea) was introduced in 1803, its accumulation in blood was dubbed urémie (uremia) in 1847, and the procedure for its removal from urine across semi-permeable ...
Source: Clinical Nephrology - February 16, 2018 Category: Urology & Nephrology Authors: Raghavan R, Eknoyan G Tags: Clin Nephrol Source Type: research

A novel UMOD gene mutation associated with chronic kidney failure at a young age.
We describe here a novel heterozygous mutation of UMOD (c.249C>G; p.Cys83Trp) in an affected 9-year-old boy with progressive renal impairment and hyperuricemia. His mother is also affected and received renal transplantation at the age of 31 years. We assume that this variant is likely to be the causative mutation in this family as it segregates with the disease, it is not present in the genomic databases, and it is predicted to be damaging by the principal software tools. Considering the progressive renal impairment of our proband at an early age (serum creatinine elevation at the age of 6, hyperuricemia at the age...
Source: Clinical Nephrology - February 9, 2018 Category: Urology & Nephrology Authors: Carucci NS, Caridi G, Lugani F, Barone C, Conti G Tags: Clin Nephrol Source Type: research

Successful use of rituximab in glomerular basement membrane nephritis associated with  HIV interstitial nephritis secondary to Castleman disease
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We report a case of glomerular basement membrane crescentic glomerulonephritis and multicentric Castleman disease-associated interstitial nephritis in a patient with human immunodeficiency virus (HIV) infection. The patient received corticosteroids, cyclophosphamide, and plasmapheresis, and within 3 weeks, there was worsening thrombocytopenia, anemia, and renal function requiring initiation of hemodialysis. He then received 8 weekly doses of rituximab, and there was steady improvement in renal function, such that he stopped dialysis within 6 weeks and has remained in disease remission at 1-year follow-up. Th...
Source: Clinical Nephrology - February 9, 2018 Category: Urology & Nephrology Authors: Calabro N, Henriksen K, Lim SH, Kerns E Tags: Clin Nephrol Source Type: research

Post-prophylaxis monitoring of CMV following renal transplantation.
PMID: 29424338 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 9, 2018 Category: Urology & Nephrology Authors: Lea-Henry T, Chacko B Tags: Clin Nephrol Source Type: research

A study of urinary Tamm-Horsfall protein excretion in adult type 2 diabetes mellitus 
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CONCLUSION: Increased albuminuria and decreased GFR are predictors of decreased urinary THP excretion. Distal convoluted tubule lesion may precede glomerular damage in a portion of T2DM patients.
. PMID: 29393842 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 2, 2018 Category: Urology & Nephrology Authors: Zheng M, Ye S, Chen Y, Chen M Tags: Clin Nephrol Source Type: research

Successful treatment of nephrotic syndrome induced by lambda light chain deposition disease using lenalidomide: A case report and  review of the literature
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CONCLUSIONS: We presented a very rare case report describing the successful treatment of LCDD (λ chain)-induced nephrotic syndrome with lenalidomide.
. PMID: 29393843 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 2, 2018 Category: Urology & Nephrology Authors: Mima A, Nagahara D, Tansho K Tags: Clin Nephrol Source Type: research

What we do and do not know about women and  kidney diseases; questions unanswered and answers unquestioned: Reflection on World Kidney Day and International Women's Day
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What we do and do not know about women and kidney diseases; questions unanswered and answers unquestioned: Reflection on World Kidney Day and International Women's Day
. Clin Nephrol. 2018 Feb 02;: Authors: Piccoli GB, Alrukhaimi M, Liu ZH, Zakharova E, Levin A Abstract Chronic kidney disease affects ~ 10% of the world's adult population: It is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's heal...
Source: Clinical Nephrology - February 2, 2018 Category: Urology & Nephrology Authors: Piccoli GB, Alrukhaimi M, Liu ZH, Zakharova E, Levin A Tags: Clin Nephrol Source Type: research

Comparison of dialysate and plasma NTproBNP in prediction of clinical outcomes of  diabetic and nondiabetic peritoneal dialysis patients
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Comparison of dialysate and plasma NTproBNP in prediction of clinical outcomes of diabetic and nondiabetic peritoneal dialysis patients
. Clin Nephrol. 2018 Jan 19;: Authors: Koz S, Sahin I, Kayatas M, Koz ST Abstract BACKGROUND: Plasma level of N-terminal pro-brain natriuretic peptide (P-NTproBNP) is a useful marker in prediction of mortality in peritoneal dialysis (PD) patients. However, the predictive value of spent dialysate counterpart (D-NTproBNP) of plasma NTproBNP on mortality and dropout is not known. MATERIALS AND METHODS: Simultaneous P-NTproBNP and D-NTproBNP assays were perfor...
Source: Clinical Nephrology - January 19, 2018 Category: Urology & Nephrology Authors: Koz S, Sahin I, Kayatas M, Koz ST Tags: Clin Nephrol Source Type: research

Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndrome 
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CONCLUSION: In this case, we believe that EBV triggered both HPS and tubulointerstitial nephritis. Steroid therapy successfully treated the inflammatory syndrome, allowing renal function recovery without compromising EBV infection resolution.
. PMID: 29350173 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 19, 2018 Category: Urology & Nephrology Authors: Godinho I, Nogueira E, Jorge S, Alves AT, Gomes da Costa A Tags: Clin Nephrol Source Type: research

Automated peritoneal dialysis could rapidly improve left heart failure by increasing peritoneal dialysis ultrafiltration: a single-center observational clinical study 
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Automated peritoneal dialysis could rapidly improve left heart failure by increasing peritoneal dialysis ultrafiltration: a single-center observational clinical study
. Clin Nephrol. 2018 Jan 19;: Authors: Yang C, Liu J, Gong N, Lin Y, He Y, Yi Z, Hu L, Jiang J, Ai J Abstract Ultrafiltration failure (UFF) is a major cause of water retention, left heart failure (LHF), and peritoneal dialysis (PD) failure. Automated peritoneal dialysis (APD) might have better ultrafiltration (UF) than continuous ambulatory peritoneal dialysis (CAPD). Here, we have studied whether short-term APD could increase UF and i...
Source: Clinical Nephrology - January 19, 2018 Category: Urology & Nephrology Authors: Yang C, Liu J, Gong N, Lin Y, He Y, Yi Z, Hu L, Jiang J, Ai J Tags: Clin Nephrol Source Type: research

Update on the nephrotoxicity of  novel anticancer agents
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This article will review the various kidney lesions observed with these new classes of anticancer drugs.
. PMID: 29350175 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 19, 2018 Category: Urology & Nephrology Authors: Nussbaum EZ, Perazella MA Tags: Clin Nephrol Source Type: research

Risk of complications with use of aspirin during renal biopsy: A systematic review.
CONCLUSIONS: There is low-quality evidence on the effect of aspirin on bleeding risk from PRB. It is reasonable to discontinue aspirin 7 - 10 days prior to nonemergent biopsies, in accordance with guidelines. Given the results from the primary studies, it is reasonable to perform randomized controlled trials to obtain high-quality evidence to inform clinical practice.
. PMID: 29319492 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 10, 2018 Category: Urology & Nephrology Authors: Kumar V, Mitchell MD, Umscheid CA, Berns JS, Hogan JJ Tags: Clin Nephrol Source Type: research

Cyclosporine for the treatment of lupus nephritis in patients with systemic lupus erythematosus.
This study aimed to assess retrospectively the efficacy and safety of cyclosporin A (CsA) therapy in patients with lupus nephritis (LN). MATERIALS AND METHODS: From September 2005 to August 2015, eligible patients with LN undergoing CsA treatment were enrolled in the study. Medical charts as well as clinical and laboratory data were retrospectively reviewed. The data were evaluated at 0, 1, 6, 12 month(s) after the start of CsA. Serum creatinine (SCr), estimated glomerular filtration rate (eGFR), urine protein/creatinine ratio (uPCR), complement components C3, C4, and anti-double stranded DNA antibody (anti-dsDNA) tit...
Source: Clinical Nephrology - January 10, 2018 Category: Urology & Nephrology Authors: Yang TH, Wu TH, Chang YL, Liao HT, Hsu CC, Tsai CY, Chou YC Tags: Clin Nephrol Source Type: research

Trend of peritoneal transport and impact on patient survival: A 10-year follow-up cohort study 
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CONCLUSION: A centripetal trend of change in peritoneal transport was observed in the first year. High peritoneal transport was associated with poorer patient outcomes only after the first few years of PD. The initial peritoneal transport status was not a determinant factor of patient survival in long-term PD.
. PMID: 29292691 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 2, 2018 Category: Urology & Nephrology Authors: Jiang C, Lo WK Tags: Clin Nephrol Source Type: research

Beh çet's syndrome and focal segmental glomerulosclerosis with nephrotic syndrome - successful treatment with etanercept
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We describe a case of a 49-year-old woman with relapsing BS symptoms coinciding with new-onset development of nephrotic syndrome. Renal biopsy showed focal segmental glomerulosclerosis (FSGS) that was treated with prednisone and etanercept for BS therapy. Both proteinuria and BS symptoms responded to treatment with complete remission. To our knowledge, our report is the first to show evidence of a possible connection between BS and FSGS and discusses the pathophysiologic mechanism that explains this link.
. PMID: 29292692 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 2, 2018 Category: Urology & Nephrology Authors: Leonard D, Cortese C, Wadei HM, Porter Ii IE, Aslam N Tags: Clin Nephrol Source Type: research

Efficacy and safety of everolimus plus low-dose calcineurin inhibitor vs. mycophenolate mofetil plus standard-dose calcineurin inhibitor in renal transplant recipients: A systematic review and meta-analysis 
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CONCLUSION: EVR plus low-dose CNI regimen was similar in efficacy and safety to MMF plus standard-dose CNI regimen after KT. However, this should be confirmed by further studies.
. PMID: 29292693 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 2, 2018 Category: Urology & Nephrology Authors: He L, Deng J, Yang B, Jiang W Tags: Clin Nephrol Source Type: research

Adult nephrotic syndrome complicated by spontaneous pneumococcal peritonitis: A case report.
PMID: 29249228 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Makedonov I, Clark EG, Kanchi P, Brown PA Tags: Clin Nephrol Source Type: research

Thrombotic microangiopathy in patients with diabetic nephropathy is associated with low VEGF expression and end-stage renal disease 
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Thrombotic microangiopathy in patients with diabetic nephropathy is associated with low VEGF expression and end-stage renal disease
. Clin Nephrol. 2017 Dec 18;: Authors: Hernández-Arteaga K, Soto-Abraham V, Pérez-Navarro M, de León-Garza B, Rodríguez-Matías A, Olvera-Soto MG, Valdez-Ortiz R Abstract BACKGROUND: Thrombotic microangiopathy (TMA) has been associated with diabetic nephropathy, but its pathogenesis is unknown. OBJECTIVES: To determine the role of vascular endothelial growth factor (VEGF) expression in patients with TMA and diabetes mellitus. ...
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Hernández-Arteaga K, Soto-Abraham V, Pérez-Navarro M, de León-Garza B, Rodríguez-Matías A, Olvera-Soto MG, Valdez-Ortiz R Tags: Clin Nephrol Source Type: research

Full age spectrum equation may be an alternative method to estimate the glomerular filtration rate in Chinese patients with chronic kidney disease 
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Full age spectrum equation may be an alternative method to estimate the glomerular filtration rate in Chinese patients with chronic kidney disease
. Clin Nephrol. 2017 Dec 18;: Authors: Chai L, Wang M, Cai K, Luo Q, Yi H, Wu J Abstract OBJECTIVE: To assess the performance of the full age spectrum (FAS) equation in comparison to other equations in subjects with chronic kidney disease (CKD) for the first time in China. MATERIALS AND METHODS: The measured glomerular filtration rate (mGFR) obtained by the 99mTc-diethylenetriamine pentaacetic acid renogram was used as the reference standard. Bias, p...
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Chai L, Wang M, Cai K, Luo Q, Yi H, Wu J Tags: Clin Nephrol Source Type: research

Hemoglobinuric acute kidney injury in a patient with a kinked prosthetic aortic graft 
.
We present a case of microangiopathic hemolytic anemia and hemoglobinuric AKI presenting 9 days after repair of an ascending aortic dissection with a prosthetic graft. After an unremarkable recovery following the initial procedure, the patient presented on postoperative day 9 with dyspnea, fatigue, and cola-colored urine. Attempts to manage conservatively with intravenous fluids, blood pressure control, and erythrocyte transfusion were unsuccessful. A magnetic resonance angiography revealed narrowing of the ascending aorta with a kink, causing turbulent blood flow. Surgical intervention was indicated due to persistent...
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Sheelvanth HV, Sayeed KA, Whittier WA Tags: Clin Nephrol Source Type: research

An integrated pathology and ultrasonography-based simulation for training in performing kidney biopsy 
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CONCLUSION: A novel KBSW is an effective educational tool to acquire proficiency in PKB performance and could help regain interest among trainees in performing PKBs.
. PMID: 29249232 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Sharma SG, Arthur JM, Bonsib SM, Phelan KD, Singh M, Karakala N, Bulloch KW, Niyyar VD, Velez JCQ Tags: Clin Nephrol Source Type: research

Abatacept efficacy in steroid-resistant minimal-change disease revealed by the speed of proteinuria reduction after the start of abatacept 
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Abatacept efficacy in steroid-resistant minimal-change disease revealed by the speed of proteinuria reduction after the start of abatacept
. Clin Nephrol. 2017 Dec 18;: Authors: Dado D, Parikh S, Ayoub I, Rovin B, Nadasdy T, Hebert L Abstract A unique characteristic of the response of minimal-change disease (MCD) or focal and segmental glomerulosclerosis (FSGS) to steroid therapy is that the remission of proteinuria occurs quickly, for example, within 4 - 6 weeks of the onset of steroid therapy, even in those with severe nephrotic syndrome. Remission of proteinuria in MCD and FSGS can also...
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Dado D, Parikh S, Ayoub I, Rovin B, Nadasdy T, Hebert L Tags: Clin Nephrol Source Type: research

High-dose melphalan and autologous hematopoietic stem cell transplant in patient  with C3 glomerulonephritis associated with monoclonal gammopathy
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We present a case of a 55-year-old man with IgG-κ gammopathy-associated C3 glomerulonephritis (C3GN) with bone marrow biopsy demonstrating 5 - 10 κ-restricted plasma cells. Following chemotherapy treatment unfortunately, the patient encountered relapsing courses of the disease. The patient subsequently received high-dose melphalan treatment followed by autologous hematopoietic stem cell transplant (ASCT). At 8 months follow-up, the patient remained hematologic response with stable kidney function. Since ASCT can offer durable hematologic remission, ASCT can potentially be a curative treatment option for pa...
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Lepori N, Cheungpasitporn W, Sethi S, Murray D, Kumar S, Leung N, Giridhar KV, Fervenza FC Tags: Clin Nephrol Source Type: research

Kidney stone composition in the Kingdom of Saudi Arabia 
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CONCLUSION: This study represents one of the largest characterizations of stone composition in the Middle East. There remains a significant gender disparity in stone prevalence in the Eastern Province of KSA, with males affected to a significantly greater extent. Calcium oxalate is the most common type of stone, and this is true for both men and women. Future investigations of dietary and environmental factors can build on these initial epidemiologic findings.
. PMID: 29249235 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Amir A, Matlaga BR, Ziemba JB, Sheikh S Tags: Clin Nephrol Source Type: research

Oxaliplatin-induced acute tubulointerstitial nephritis: Two case reports 
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This report describes two patients who had received repetitive combination chemotherapy including oxaliplatin for the treatment of metastatic colon cancer and who visited the emergency department with acute kidney injury several days after experiencing a hypersensitivity reaction to oxaliplatin. In both cases, the pathologic diagnosis was acute tubulointerstitial nephritis, and corticosteroid therapy resulted in improved renal function. Induction of acute tubulointerstitial nephritis by oxaliplatin has rarely been reported.
. PMID: 29231160 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 12, 2017 Category: Urology & Nephrology Authors: Choi YJ, Oh KH, Kang HR, Lee SJ Tags: Clin Nephrol Source Type: research

Pleural and pericardial effusion in a long-term PD patient - a defying diagnosis 
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We present the case of a 37-year-old woman on PD for 24 months exhibiting a left pleural and pericardial effusion following pneumonia. Pleural fluid was initially compatible with an exudate with a high glucose concentration and later with a transudate. In order to clarify the suspicion of an ongoing shunt an abdominal scintigraphy was performed confirming the diagnosis of a peritoneopleuropericardial communication. This case underlines the importance of considering this unusual diagnosis in a patient on long-term PD. Its timely diagnosis is important to stop PD and start hemodialysis.
. PMID: 29231161 [PubMed -...
Source: Clinical Nephrology - December 12, 2017 Category: Urology & Nephrology Authors: Godinho I, Dias JM, Rodrigues N, Silva H, Jorge S, Abreu CP, Lopes JA Tags: Clin Nephrol Source Type: research

Evaluation of clinical outcomes among nonvalvular atrial fibrillation patients treated with rivaroxaban or warfarin, stratified by renal  function
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Evaluation of clinical outcomes among nonvalvular atrial fibrillation patients treated with rivaroxaban or warfarin, stratified by renal function
. Clin Nephrol. 2017 Dec 12;: Authors: Weir MR, Haskell L, Berger JS, Ashton V, Laliberté F, Crivera C, Brown K, Lefebvre P, Schein J Abstract BACKGROUND: Renal dysfunction increases the risk of thromboembolic and bleeding events in patients with nonvalvular atrial fibrillation (NVAF). MATERIALS AND METHODS: Adult NVAF patients with ≥ 6 months prior to first warfarin or rivaroxaban dispensing were selected from the IMS Health Real-World...
Source: Clinical Nephrology - December 12, 2017 Category: Urology & Nephrology Authors: Weir MR, Haskell L, Berger JS, Ashton V, Laliberté F, Crivera C, Brown K, Lefebvre P, Schein J Tags: Clin Nephrol Source Type: research

Durable renal response after combination of bortezomib, corticosteroids, rituximab, and plasmapheresis for late antibody-mediated renal transplant rejection 
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CONCLUSION: Renal allograft survival was 82% at 4 years after bortezomib-based therapy for late onset AMR; toxicity profile of this regimen was acceptable. Eradication of DSAs may not be necessary for meaningful and durable renal response.
. PMID: 29208204 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 6, 2017 Category: Urology & Nephrology Authors: Ding Y, Francis J, Gautam A, Pelletier L, Sanchorawala V, Quillen K Tags: Clin Nephrol Source Type: research

Dense deposit disease associated with multiple myeloma 
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Dense deposit disease associated with multiple myeloma
. Clin Nephrol. 2017 Dec 06;: Authors: Alkhunaizi AM, AlKhatti AA, Nasr SH, Alexander MP Abstract Dense deposit disease (DDD) is a very rare pathological finding associated with activation of the final complement pathway. DDD has been rarely found in association with multiple myeloma (MM). Here we report a patient with MM presenting with renal failure, anemia, and bone pain. The renal biopsy showed DDD. The patient received anti-myeloma treatment and responded well. The case is discussed and literature reviewed.
. PMID: 29208205 [PubMed -...
Source: Clinical Nephrology - December 6, 2017 Category: Urology & Nephrology Authors: Alkhunaizi AM, AlKhatti AA, Nasr SH, Alexander MP Tags: Clin Nephrol Source Type: research