The expression of platelet-derived growth factor receptor alpha-positive cells in the stenotic tissue of ureteropelvic junction obstruction in children 
.
CONCLUSION: This study identified the expression of PDGFRα+ cells in the human UPJ. Our results demonstrate the expression of SK3 channels in PDGFRα+ cells was decreased in UPJO, and SK3 channels may be involved in the pathogenesis of UPJO by perturbing the UPJ peristalsis.
. PMID: 32049626 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 12, 2020 Category: Urology & Nephrology Authors: Wang T, Zhang W, Han W Tags: Clin Nephrol Source Type: research

Phosphates in medications: Impact on dialysis  patients
.
Phosphates in medications: Impact on dialysis patients
. Clin Nephrol. 2020 Feb 12;: Authors: Sawin DA, Ma L, Stennett A, Ofsthun N, Himmele R, Kossmann RJ, Maddux FW Abstract Maintaining phosphorus balance in in-center hemodialysis (ICHD) patients is problematic despite recommended dietary restriction, dialysis, and phosphate binder use. Rarely is P content in prescribed medications considered, but this source should raise concern. Data was obtained from the Fresenius Kidney Care (FKC) electronic data warehouse Knowledge Center and MedReview-eRx accessed Surescripts, housing> 80% of US...
Source: Clinical Nephrology - February 12, 2020 Category: Urology & Nephrology Authors: Sawin DA, Ma L, Stennett A, Ofsthun N, Himmele R, Kossmann RJ, Maddux FW Tags: Clin Nephrol Source Type: research

Kidney health for everyone everywhere - from prevention to detection and equitable access to care.
Abstract The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Crucially, however, the onset and progression of CKD is often preventable. In 2020, the World Kidney Day campaign highlights the importance of preventive interventions - be it primary, secondary or tertiary. This complementing article focuses on outlining...
Source: Clinical Nephrology - February 4, 2020 Category: Urology & Nephrology Authors: Li PK, Garcia-Garcia G, Lui SF, Andreoli S, Fung WW, Hradsky A, Kumaraswami L, Liakopoulos V, Rakhimova Z, Saadi G, Strani L, Ulasi I, Kalantar-Zadeh K Tags: Clin Nephrol Source Type: research

Predictive value of renal resistive index for the  onset of acute kidney injury and its non-recovery: A systematic review and meta-analysis
.
Predictive value of renal resistive index for the onset of acute kidney injury and its non-recovery: A systematic review and meta-analysis
. Clin Nephrol. 2020 Feb 04;: Authors: Wu H, Liu K, Darko IN, Xu X, Li L, Xing C, Mao H Abstract BACKGROUND: The predictive value of Doppler-based renal resistive index (RRI) for acute kidney injury (AKI) has not been fully elucidated. The present meta-analysis was carried out to disclose the correlation between AKI and RRI, and to investigate the predictive value of RRI for the onset of AKI and its recovery. MATERIALS AND METHODS: We searched PubMed, E...
Source: Clinical Nephrology - February 4, 2020 Category: Urology & Nephrology Authors: Wu H, Liu K, Darko IN, Xu X, Li L, Xing C, Mao H Tags: Clin Nephrol Source Type: research

Doubts about the efficacy of tolvaptan for polycystic kidney disease.
PMID: 32000887 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 30, 2020 Category: Urology & Nephrology Authors: Anderson CL Tags: Clin Nephrol Source Type: research

Reply to Dr. Anderson's letter.
PMID: 32000888 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 30, 2020 Category: Urology & Nephrology Authors: Gansevoort RT Tags: Clin Nephrol Source Type: research

Kidney dysfunction is associated with risk of cardiovascular events in middle-aged and elderly population with hypertension: A  5-year community-based cohort study in China
.
CONCLUSION: Moderate to severe kidney dysfunction was an independent risk predictor of CVD events. Among subjects with hypertension or poorly controlled blood pressure level, the presence of CKD significantly increased the risks of CVD events and stroke.
. PMID: 31983380 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 27, 2020 Category: Urology & Nephrology Authors: Gu X, Fang X, Ji X, Tang Z, Wang C, Guan S, Wu X, Liu H, Zhang Z Tags: Clin Nephrol Source Type: research

A child with atypical hemolytic uremic syndrome: Is there a rationale to stop eculizumab?
PMID: 31983381 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 27, 2020 Category: Urology & Nephrology Authors: Kersnik Levart T Tags: Clin Nephrol Source Type: research

What every nephrologist needs to know about hydroxychloroquine toxicity 
.
This report describes such a situation, which had devastating consequences for the patient. On this basis we suggest that this report is a story worth telling, and should encourage the nephrologist to be more involved in their patients' HCQ management.
. PMID: 31983382 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 27, 2020 Category: Urology & Nephrology Authors: Ayoub I, Singh P, Ardoin S, Brodsky S, Hebert L Tags: Clin Nephrol Source Type: research

Relationship between abdominal aortic calcification on plain radiograph and coronary artery calcification detected by computed tomography in hemodialysis patients 
.
Relationship between abdominal aortic calcification on plain radiograph and coronary artery calcification detected by computed tomography in hemodialysis patients
. Clin Nephrol. 2020 Jan 27;: Authors: Cho A, Jung HY, Park HC, Oh J, Kim J, Lee YK Abstract PURPOSE: Abdominal aortic calcification (AAC) can be assessed easily using a plain radiograph. We investigated the relationship between AAC assessed by plain radiography and coronary artery calcification (CAC) assessed by computed tomography (CT). MATERIALS AND METHODS: 62 hemodialysis patients who underwent lumbar lateral radiography and mult...
Source: Clinical Nephrology - January 27, 2020 Category: Urology & Nephrology Authors: Cho A, Jung HY, Park HC, Oh J, Kim J, Lee YK Tags: Clin Nephrol Source Type: research

Boswellia serrata extract ingestion and glomerular filtration rate.
t E PMID: 31983384 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 27, 2020 Category: Urology & Nephrology Authors: Lhotta K, Sprenger-Mähr H, Zitt E Tags: Clin Nephrol Source Type: research

Effect of nurse-led food exchange intervention for patients undergoing peritoneal dialysis 
.
Effect of nurse-led food exchange intervention for patients undergoing peritoneal dialysis
. Clin Nephrol. 2020 Jan 15;: Authors: Luo Y, Huang Y, Zhang Y, Xiang J, Wu Q Abstract AIM: We aimed to apply nurse-led food exchange model intervention to peritoneal dialysis (PD) patients and verify its effectiveness. BACKGROUND: Protein-energy malnutrition is a prominent problem in patients on PD, and it has been estimated that 40% of PD patients suffer from malnutrition to some extent. INTRODUCTION: The rate of malnutrition among PD patients has been relatively high in recent years. Although a lo...
Source: Clinical Nephrology - January 15, 2020 Category: Urology & Nephrology Authors: Luo Y, Huang Y, Zhang Y, Xiang J, Wu Q Tags: Clin Nephrol Source Type: research

Can ferric citrate lead to iron overload in peritoneal dialysis patients? 
.
We present a series of 3 PD patients who developed iron overload while receiving FC for management of hyperphosphatemia. These cases highlight the importance of close monitoring of iron studies and question whether a lower maximum dose of FC should be recommended in PD patients. Further studies are needed to assess the safety of the maximum approved dose of FC among PD patients.
. PMID: 31933474 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 14, 2020 Category: Urology & Nephrology Authors: Aslam N, Govani M, Basdeo LM, Wadei HM Tags: Clin Nephrol Source Type: research

The ongoing search for a robust clinical prediction model of ICU AKI.
PMID: 31933475 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 14, 2020 Category: Urology & Nephrology Authors: McCoy IE, Chertow GM Tags: Clin Nephrol Source Type: research

Coincidental crystalline light chain cast nephropathy, light chain proximal tubulopathy, and urine crystallopathy: A case report and review of the literature 
.
We report here the co-occurrence of these two monoclonal crystalline forms of acute kidney injury in a 66-year-old woman with known history of κ-restricted multiple myeloma. Additionally, forms suggestive of a crystalline morphology were observed in the urine sediment. Clinicians who observe similar crystalline structures on renal biopsy or in urine sediment should have a high index of suspicion for underlying multiple myeloma as a unifying diagnosis.
. PMID: 31907143 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 7, 2020 Category: Urology & Nephrology Authors: Lerner G, Moradi S, Cohen-Bucay A, Chen H, Sanchorawala V, Gordon CE, Henderson JM Tags: Clin Nephrol Source Type: research

Monoclonal immunoglobulin G1 κ-type atypical antiglomerular basement membrane disease accompanied by necrotizing glomerulonephritis
.
CONCLUSION: We described an atypical variant of anti-GBM disease due to monoclonal IgG1-κ. Unlike usual atypical anti-GBM disease cases, we observed crescent formation in our patient. Further investigations are needed to identify the cause of nondetectable serum anti-GBM antibodies and to describe the causal relationships between clinicopathological features and the pattern of IgG subclass and light chain in atypical anti-GBM disease.
. PMID: 31854296 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 19, 2019 Category: Urology & Nephrology Authors: Tsuji T, Ohashi N, Sato T, Goto D, Nagata S, Matsuyama T, Naito Y, Tsuji N, Isobe S, Fujikura T, Kato A, Fujigaki Y, Shimizu A, Yasuda H Tags: Clin Nephrol Source Type: research

Nontraditional (non-Western pharmaceutical) treatments for chronic kidney disease.
Abstract Nontraditional, non-Western medicines, often called complementary and alternative medicines (CAM), for chronic kidney disease (CKD) patients are, potentially, a huge low-cost therapy resource for poorer populations in the world. Use of CAM, particularly from plant sources, is common in poorer communities, but the scientific basis for their use is still under-researched and under-published. This review presents information on the treatment of kidney disease with CAM, particularly CKD and its closely associated cardiovascular disease (CVD), which might benefit vulnerable populations. The challenges of devel...
Source: Clinical Nephrology - December 12, 2019 Category: Urology & Nephrology Authors: Gobe GC, Wojcikowski K Tags: Clin Nephrol Source Type: research

Clinical significance of urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in immunoglobulin A nephropathy 
.
Clinical significance of urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in immunoglobulin A nephropathy
. Clin Nephrol. 2019 Dec 12;: Authors: Kim JS, Jeong KH Abstract AIMS: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes. Recently, it was reported that TWEAK may play an important role in the pathogenesis of kidney damage. In the present study, we investigated the role of TWEAK in immunoglobulin A nephropathy (IgAN). MATERIALS AND METHODS: The levels of serum TWEAK (sTWEAK) and urinary TWEAK ...
Source: Clinical Nephrology - December 12, 2019 Category: Urology & Nephrology Authors: Kim JS, Jeong KH Tags: Clin Nephrol Source Type: research

Resolution of syphilis-related rapidly progressive glomerulonephritis with penicillin therapy: Case report 
.
We report a rare case of RPGN secondary to latent syphilis, which resolved with penicillin treatment in the absence of immunosuppressive therapy. A 28-year-old Black male with a history of HIV was evaluated for severe acute kidney injury, nephrotic-range proteinuria, and active urine sediment. Serologies for glomerulonephritis were negative. Rapid plasma reagin and treponema pallidum particle agglutination assay were reactive, confirming syphilis diagnosis. Kidney biopsy revealed focal and segmental necrotizing and crescentic lesion. Patient received weekly benzathine penicillin (PCN) for 3 weeks, and renal function improv...
Source: Clinical Nephrology - December 9, 2019 Category: Urology & Nephrology Authors: Nandikanti DK, George LK, Walker PD, Kumar A, Wall BM Tags: Clin Nephrol Source Type: research

The relationship between urinary kidney injury molecule-1 and blood bone metabolism markers in patients with chronic kidney disease 
.
CONCLUSION: UKIM-1/uCr levels are increased with the deterioration of CKD stage and are correlated with the development of CKD-mineral and bone disorder (CKD-MBD).
. PMID: 31793871 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 3, 2019 Category: Urology & Nephrology Authors: Yin C, Cheng C, Wang J, Zhang L, Purrunsing Y, Yang G, Zeng M, Huang H, Ren W, Ye Y, Ma H, Xing C, Wang N Tags: Clin Nephrol Source Type: research

Female gender and overestimation of glomerular filtration rate: Independent predictors of acute kidney injury after liver transplantation 
.
Female gender and overestimation of glomerular filtration rate: Independent predictors of acute kidney injury after liver transplantation
. Clin Nephrol. 2019 Dec 03;: Authors: Tinti F, Melandro F, Umbro I, Fiacco F, Zavatto A, Ginanni Corradini S, Lai S, Berloco PB, Rossi M, Mitterhofer AP Abstract Acute kidney injury (AKI) in liver transplant (LT) setting is a recognized complication and is related to increased morbidity and mortality. Pre-LT renal function is difficult to estimate, in particular for the female gender. The aim of the study was to evaluate the incidence of post-LT AKI, its relation...
Source: Clinical Nephrology - December 3, 2019 Category: Urology & Nephrology Authors: Tinti F, Melandro F, Umbro I, Fiacco F, Zavatto A, Ginanni Corradini S, Lai S, Berloco PB, Rossi M, Mitterhofer AP Tags: Clin Nephrol Source Type: research

Burden of disease: Closing the gaps in the burden of end-stage kidney disease in Latin America.
Abstract End-stage kidney disease (ESKD) represents a major challenge for Latin America (LA). The Latin American Dialysis and Renal Transplantation Registry (LADRTR) has published several reports, and its continuity has implied a sustained effort of the nephrology community to improve care of ESKD in the region; this paper summarizes results of the year 2014. Methods have been reported previously; participant countries complete annual surveys collecting data on incident and prevalent patients undergoing renal replacement therapy (RRT) in all modalities. 20 countries participated in the surveys (more than 90% of th...
Source: Clinical Nephrology - December 3, 2019 Category: Urology & Nephrology Authors: Gonzalez-Bedat MC, Rosa-Diez G, Ferreiro-Fuentes A, Douthat W, Cueto-Manzano A, Fernandez-Cean JM Tags: Clin Nephrol Source Type: research

Burden of disease: Prevalence and incidence of endstage renal disease in Middle Eastern countries.
CONCLUSION: There is a high CKD burden in the ME countries. There needs to be emphasis on prevention of ESRD and provision of adequate care for the total ESRD patient population. National renal registries are needed to monitor the status of ESRD patients. Health expenditures should be increased to cover all aspects of RRT in ME Countries. PMID: 31793874 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 3, 2019 Category: Urology & Nephrology Authors: Shaheen FAM, Al-Attar B, Ahmad MK, Follero PM Tags: Clin Nephrol Source Type: research

The role of serum E-selectin level and E-selectin gene S128R polymorphism on the  enlargement of renal cyst in patients with polycystic kidney disease: Genetic background of renal cyst growth
.
CONCLUSION: PKD patients with CC variants of the E-selectin gene S128R polymorphism are at greater risk of cyst enlargement. The results of the present study should be confirmed with further studies with large sample size and longer duration of follow-up.
. PMID: 31746731 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 20, 2019 Category: Urology & Nephrology Authors: Esen B, Sayin T, Akbas H, Gokmen ES, Atay AE, Guzel SP, Gorgulu N, Yavuz DG Tags: Clin Nephrol Source Type: research

Chronic interstitial nephritis of nontraditional causes in Salvadoran agricultural communities.
This article summarizes the results obtained from a series of studies conducted to identify the epidemiology and clinical behavior of this disease, proposing a case definition and an etiopathogenic hypothesis. Methods included a survey of CKD in agricultural communities studying 2,388 people ≥ 18 years and 1,755
Source: Clinical Nephrology - November 8, 2019 Category: Urology & Nephrology Authors: Herrera Valdés R, Almaguer López M, Orantes Navarro CM, López Marín L, Brizuela Díaz EG, Bayarre Vea H, Amaya Medina JC, Silva Ayçaguer LC, Vela Parada XF, Zelaya Quezada S, Orellana de Figueroa P, Smith González M, Chávez Muñoz Y, García Ortiz Tags: Clin Nephrol Source Type: research

Renal thrombotic microangiopathy during nintedanib treatment for idiopathic pulmonary fibrosis 
.
We describe a case of a 45-year-old male who presented with isolated proteinuria of 1.3 g/g Cr 3 years after beginning nintedanib treatment. The kidney biopsy revealed histological features consistent with renal TMA. He underwent single lung transplantation 6 months later, which enabled cessation of nintedanib, and, 1 month later, his proteinuria results were negative. Unlike other types of TKIs, the pathological findings of nintedanib-induced nephrotoxicities have been limitedly reported. This is the first case of isolated proteinuria likely caused by nintedanib-induced TMA.
. PMID: 31699213 [PubMed - as supplied b...
Source: Clinical Nephrology - November 8, 2019 Category: Urology & Nephrology Authors: Inoue D, Nishi H, Honda K, Ishii T, Abe H, Sato M, Nangaku M Tags: Clin Nephrol Source Type: research

Response to treatment in kidney transplant recipients with acute antibody-mediated rejection: A follow-up biopsy study 
.
CONCLUSION: With effective antibody mediated rejection (AMR) therapy, renal function parameters were significantly improved. Histologically, improvement in tubulointerstitial inflammation may be responsible for this process. However, progressive chronic changes, particularly in the glomeruli, are noteworthy.
. PMID: 31670649 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 31, 2019 Category: Urology & Nephrology Authors: Taslı Alkan F, Tatar E, Karatas M, Simsek C, Can Tercan I, Aykas A, Uslu A Tags: Clin Nephrol Source Type: research

Correlation of IL-6 secretion and hyponatremia with the use of CD19+ chimeric antigen receptor T-cells 
.
CONCLUSION: Hyponatremia is common in patients who received CD19+ CAR T-cells. There is an inverse linear relationship between IL-6 levels and nadir Na (p = 0.001). Further studies will be needed to confirm a causative relationship between IL-6 levels and hyponatremia following CD19+ CAR T-cell infusion.
. PMID: 31670650 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 31, 2019 Category: Urology & Nephrology Authors: Dixon BN, Daley RJ, Buie LW, Hsu M, Park JH, Brentjens RJ, Purdon TJ, Latcha S Tags: Clin Nephrol Source Type: research

Alemtuzumab induction for retransplantation after primary transplant with alemtuzumab induction 
.
CONCLUSION: Patients with repeat courses of ALEM induction across multiple transplants may have a higher incidence of fungal infection. Future studies are needed to explore this risk, particularly in light of current drug manufacturer allocation practices and potential increased utilization by transplant centers.
. PMID: 31670651 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 31, 2019 Category: Urology & Nephrology Authors: Descourouez JL, Jorgenson MR, Parajuli S, Mandelbrot DA, Leverson GE, Odorico JS, Redfield RR Tags: Clin Nephrol Source Type: research

Mechanisms of kidney disease in Sneddon's syndrome: Case report and literature review 
.
We report a case of Sneddon's syndrome with chronic kidney disease, associated with features of endarteritis obliterans in the skin and the kidney. The clinical presentation of our patient is compared to previously reported cases of Sneddon's syndrome with biopsy-proven kidney disease. We also discuss the differential diagnosis, pathophysiological mechanisms, relationship with antiphospholipid syndrome, and management of patients with Sneddon's syndrome and kidney disease. This clinical observation supports the systemic nature of Sneddon's syndrome and provides insights into the mechanisms by which this rare but probably u...
Source: Clinical Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Ghislain L, Aydin S, Marot L, Demoulin N, Morelle J Tags: Clin Nephrol Source Type: research

Bartter syndrome type III with only a synonymous mutation of the CLCNKB gene 
.
In this report, we describe an adult patient with longstanding clinical symptoms of fatigue, polyuria, polydipsia, mental retardation, and physical dysplasia along with hypokalemia and metabolic alkalosis as laboratory findings. With these clinical symptoms, a patient can be diagnosed with BS type III. Renal biopsy and genetic testing were performed for further confirmation of the diagnosis, revealing renin granular deposits in the juxtaglomerular apparatus (JA) with JA hyperplasia. DNA sequencing detected a heterozygous synonymous mutation, c.1140G>A, in exon 12 of the CLCNKB gene, which could be traced back to a heter...
Source: Clinical Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Xue Y, Wang B, Tang R, Ni H, Chen P, Liu BC, Zhang X Tags: Clin Nephrol Source Type: research

Effects of allopurinol pretreatment on the risk of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled trials 
.
Effects of allopurinol pretreatment on the risk of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled trials
. Clin Nephrol. 2019 Oct 29;: Authors: Xin W, Lin Z, Zhang T, Jia S Abstract BACKGROUND: Treatment with allopurinol has been suggested to reduce the incidence of contrast-induced acute kidney injury (CI-AKI). However, results of previous randomized controlled trials (RCTs) are not consistent. We performed a meta-analysis to evaluate the influence of allopurinol on the risk of CI-AKI. MATERIALS AND METHO...
Source: Clinical Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Xin W, Lin Z, Zhang T, Jia S Tags: Clin Nephrol Source Type: research

Suspension precipitation: A simple sediment-collecting method for microbiological culturing in diagnosis of peritonitis 
.
CONCLUSION: The suspension precipitation method is a simple, convenient, and reliable peritoneal sediment-collecting method that is suitable for a wide array of uses, particularly in basic-level hospitals without centrifugation technology.
. PMID: 31661062 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Ye P, Ye H, Zhang L, Yu C, Liang Z, Zhang Z, Li W, Wu K, Kong Y Tags: Clin Nephrol Source Type: research

The association of smoking with ultrasound-measured kidney dimensions 
.
The association of smoking with ultrasound-measured kidney dimensions
. Clin Nephrol. 2019 Oct 29;: Authors: Farhat A, Jones IA, Saadat S, Dornhofer K, Kong C, Nguyen T, Lahham S, Fox JC Abstract PURPOSE: Ultrasound is considered a preferred first-line imaging technique for the assessment of kidney function. The potential relationship between tobacco smoke exposure and ultrasound-measured renal characteristics has yet to be explored. We hypothesized that exposure to tobacco smoke would be associated with reduced kidney dimensions. MATERIALS AND METHODS: This was a cross-sectional study that inc...
Source: Clinical Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Farhat A, Jones IA, Saadat S, Dornhofer K, Kong C, Nguyen T, Lahham S, Fox JC Tags: Clin Nephrol Source Type: research

Eculizumab in post-transplant C3 glomerulonephritis caused by a C3 mutation 
.
In this report, we describe the successful use of eculizumab to treat a patient with recurrent post-transplant C3GN caused by a C3 gene gain-of-function mutation, and also review the published literature regarding the use of eculizumab for the treatment of recurrent C3 glomerulopathy.
. PMID: 31661064 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Kim JS, Foster KW, Westphal SG Tags: Clin Nephrol Source Type: research

Chronic disease burdens of incident U.S.  dialysis patients, 1996 - 2015
.
DISCUSSION: Mortality and cardiovascular disease burden have declined for dialysis patients in the United States despite an aging population that is increasingly hypertensive and diabetic. Comorbid disease burdens among HD and PD patients have diverged over time, with PD patients having fewer comorbid conditions.
. PMID: 31599226 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 10, 2019 Category: Urology & Nephrology Authors: McGill RL, Bragg-Gresham JL, He K, Lacson EK, Miskulin DC, Saran R Tags: Clin Nephrol Source Type: research

Screening for sleep disorders in patients with advanced chronic kidney disease or end-stage kidney disease 
.
CONCLUSION: Commonly used screening questionnaires do not accurately predict sleep disorders in the context of advanced CKD or ESKD. Wrist actigraphy accurately identifies those with low sleep efficiency and long time spent awake after sleep onset, who are likely to have the highest diagnostic yield with PSG. Neither approach obviates the need for PSG for accurate diagnosis of sleep disorders in this population.
. PMID: 31599227 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 10, 2019 Category: Urology & Nephrology Authors: Kennedy C, Kane T, Costello R, Conlon P Tags: Clin Nephrol Source Type: research

Rupture of peritoneal dialysis catheter with no drainage failure.
PMID: 31599228 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 10, 2019 Category: Urology & Nephrology Authors: Rodriguez-Santos R, Garcia-Everett A, Kessler R, Bansal S Tags: Clin Nephrol Source Type: research

Pregnancy outcomes and chronic kidney disease: Ecuadorian single center experience 
.
DISCUSSION: Pregnancy in women with ESRD is complicated by increased adverse maternal and fetal outcomes, these remain high in women with kidney disease notwithstanding advances in obstetric and neonatal care. A HD condition seems to be related to worse outcomes. Preconception counseling and tight control after conception, including multidisciplinary evaluation and individualized therapy should be done.
. PMID: 31587752 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 7, 2019 Category: Urology & Nephrology Authors: Moscoso-Solorzano GT, Farfan Jimenez AG Tags: Clin Nephrol Source Type: research

Quality of life in patients with autosomal dominant tubulointerstitial kidney disease 
.
CONCLUSION: Genetic testing of presymptomatic patients for ADTKD is reasonable when requested. This study provides reassurance regarding the impact on QOL of the increased use of genetic testing to diagnose kidney disease. ADTKD has a significant impact on QOL, with depression, not anxiety, being more prevalent in affected individuals.
. PMID: 31587753 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 7, 2019 Category: Urology & Nephrology Authors: Bleyer AJ, Kidd K, Johnson E, Robins V, Martin L, Taylor A, Pinder AJ, Bowline I, Frankova V, Živná M, Taylor KB, Kim N, Baek JJ, Hartmannová H, Hodaňová K, Vyleťal P, Votruba M, Kmoch S Tags: Clin Nephrol Source Type: research

Cinacalcet for secondary hyperparathyroidism in end-stage renal disease patients below age 5 years 
.
Cinacalcet for secondary hyperparathyroidism in end-stage renal disease patients below age 5 years
. Clin Nephrol. 2019 Oct 07;: Authors: Joseph C, Shah S, Geer J, Juarez-Calderon M, Srivaths PR, Swartz SJ Abstract BACKGROUND: Management of chronic kidney disease mineral bone disorder (CKD-MBD) in pediatric patients with end-stage renal disease (ESRD) is challenging. While the use of calcimimetics is well-studied in adults on dialysis, few studies have been performed in pediatrics. Little is known about the use of cinacalcet in young children with ESRD. The aim of this study was to report the effica...
Source: Clinical Nephrology - October 7, 2019 Category: Urology & Nephrology Authors: Joseph C, Shah S, Geer J, Juarez-Calderon M, Srivaths PR, Swartz SJ Tags: Clin Nephrol Source Type: research

Estimation of glomerular filtration rate based on dry lean body mass in kidney transplant recipients 
.
CONCLUSION: Dry lean body mass improves the performance of GFR equations in our kidney transplant cohort.
. PMID: 31587755 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 7, 2019 Category: Urology & Nephrology Authors: Borštnar Š, Lindič J, Ležaič L, Sočan A, Godnov U, Kovač D Tags: Clin Nephrol Source Type: research

The association between proinflammatory cytokines and kidney function, body composition, and nutritional markers in nondialysis-dependent chronic kidney disease  patients with diabetes mellitus type 2
.
CONCLUSION: In CKD patients with diabetes mellitus type 2 during conservative treatment, IL-6 levels were associated with kidney function expressed by eGFR. IL-6 levels and IFN-γ levels negatively correlated with the amount of muscle mass. Cytokines did not show any association with the amount of fat tissue this study.
. PMID: 31549627 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 24, 2019 Category: Urology & Nephrology Authors: Rymarz A, Rzeszotarska A, Boniecka I, Korsak J, Niemczyk S Tags: Clin Nephrol Source Type: research

Outcomes of malignant melanoma in kidney transplant recipients 
.
Outcomes of malignant melanoma in kidney transplant recipients
. Clin Nephrol. 2019 Sep 24;: Authors: Di Bartolomeo S, Rolak S, Joachim E, Xu YG, Astor BC, Parajuli S Abstract Kidney transplant recipients (KTRs) have an increased risk of skin cancer. We analyzed the outcomes of KTRs transplanted at our center between January 1, 1994, and December 31, 2015, who reported pretransplant melanoma or had post-transplant de novo melanoma. Of 6,522 kidney or kidney with pancreas transplant recipients, 37 had pretransplant melanoma. After adjustment of multiple variables, pretransplant melanoma was associate...
Source: Clinical Nephrology - September 24, 2019 Category: Urology & Nephrology Authors: Di Bartolomeo S, Rolak S, Joachim E, Xu YG, Astor BC, Parajuli S Tags: Clin Nephrol Source Type: research

Prevalence and incidence of chronic kidney disease in Cuba.
This article's objective is to describe CKD's integration into Cuba's National Noncommunicable Diseases (NCD) Program and the main outcomes regarding the burden of CKD and associated risk factors in Cuba. Cuba offers free health services to all its citizens on the basis of a strong primary healthcare system focused on prevention. The CKD National Program is coordinated by the Institute of Nephrology and includes the National Program for Prevention of CKD, which addresses all levels of prevention. The following indicators for renal replacement treatment are from 2016. The incidence of new patients on dialysis was 109 per mi...
Source: Clinical Nephrology - September 24, 2019 Category: Urology & Nephrology Authors: Herrera Valdés R, Almaguer López M, Chipi Cabrera JA, Pérez-Oliva Díaz JF, Landrove Rodríguez O, Mármol Sóñora A Tags: Clin Nephrol Source Type: research

Hypertension and kidney disease progression.
Abstract Hypertension is a common finding in patients with chronic kidney disease (CKD) and it is associated with kidney disease progression. Hypertensive nephropathy is a diagnosis, mostly based on clinical suspicion and defines many cases of CKD of unknown etiology. The risk of progression of hypertension-attributed nephropathy seems to have a genetic background as has been demonstrated in African-American patients with APOL1 gene risk variants.
. PMID: 31549630 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 24, 2019 Category: Urology & Nephrology Authors: Rigo D, Orias M Tags: Clin Nephrol Source Type: research

Interleukin-6, procalcitonin, and vascular endothelial growth factor in plasma and dialysate correlate with dialysis adequacy in continuous ambulatory peritoneal dialysis patients.
PMID: 31496510 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2019 Category: Urology & Nephrology Authors: Boonyarittipong M, Kurathong S, Trakarnvanich T Tags: Clin Nephrol Source Type: research

Comparison of urea clear space and eKt/V during online hemodiafiltration.
PMID: 31496511 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2019 Category: Urology & Nephrology Authors: Nakayama T, Kawauchi R, Hirano K Tags: Clin Nephrol Source Type: research

Basilic vein transposition-radial artery fistula created using the no-touch technique 
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CONCLUSION: Forearm BVT-AVF created by the no-touch technique is a good alternative access for patients in whom the standard arteriovenous fistula cannot be established.
. PMID: 31496512 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2019 Category: Urology & Nephrology Authors: Ye TT, Zhang L, Shen JM, Li WW, He D, Shi CH, Deng YY Tags: Clin Nephrol Source Type: research

Cardiologists' and nephrologists' management of atrial fibrillation in hemodialysis patients 
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Cardiologists' and nephrologists' management of atrial fibrillation in hemodialysis patients
. Clin Nephrol. 2019 Sep 09;: Authors: Marcus L, Mackeigan L, Leblanc K, Orlov D, Mitsakakis N, Austin Z, Jassal SV, Battistella M Abstract BACKGROUND: Antithrombotic therapy for stroke prevention in atrial fibrillation (AF) is considered a standard of care, but for hemodialysis (HD) patients the benefits are unclear, and bleeding risks are high. Our study objective was to compare cardiologists' and nephrologists' stroke prevention practices in different patient risk scenarios. MATERIALS AND METHODS: A ...
Source: Clinical Nephrology - September 9, 2019 Category: Urology & Nephrology Authors: Marcus L, Mackeigan L, Leblanc K, Orlov D, Mitsakakis N, Austin Z, Jassal SV, Battistella M Tags: Clin Nephrol Source Type: research