A unique case of purple urine: A case report and literature review.
We present a case of purple urine in a patient who received methylene blue and hydroxocobalamin for catecholamine-refractory vasodilatory shock. The patient's purple urinary discoloration is presumed to have resulted from a combination of the blue and red pigments of methylene blue and hydroxocobalamin, respectively. As these drugs are increasingly being used to treat vasoplegia in cardiopulmonary bypass, it is important for clinicians to be aware of this benign cause of urine discoloration. PMID: 33605870 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 19, 2021 Category: Urology & Nephrology Authors: Aklilu AM, Avigan ZM, Brewster UC Tags: Clin Nephrol Source Type: research

The relevance of performing 24-hour ambulatory blood pressure and pulse wave  analysis in kidney transplant recipients.
Conclusion: In kidney transplant recipients, 24-hour ABPM was superior to office BP in defining hypertensive status that qualified for modification of therapy, but PWA did not contribute to risk assessment. PMID: 33605871 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 19, 2021 Category: Urology & Nephrology Authors: Mzingeli L, Jones E, Barday Z, Rayner B Tags: Clin Nephrol Source Type: research

Renally inappropriate medications in elderly patients with chronic kidney disease.
PMID: 33605872 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 19, 2021 Category: Urology & Nephrology Authors: Yasu T, Hayashi D, Saitoh M, Yashiro Y, Shirota M Tags: Clin Nephrol Source Type: research

Evolution of IgA nephropathy in Singapore over four decades and a comparison of two cohorts from the first and fourth decade.
CONCLUSION: The Oxford MEST classification offers a robust and expressive classification for early and late disease progression with respect to the development of end-stage renal disease (ESRD). E and S seem to be indices of continuing disease activity with progressive glomerulosclerosis, probably still amenable to therapy, but T was a predictive indicator for those destined for ESRD and no longer amenable to therapy. PMID: 33605873 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 19, 2021 Category: Urology & Nephrology Authors: Woo KT, Chan CM, Foo M, Lim C, Choo J, Chin YM, Teng EWL, Mohamed Yusoff PA, Mok I, Kwek JL, Tan HZ, Loh AHL, Choong HL, Tan HK, Wong KS, Lee GSL, Lee E, Tan PH, Tan CS Tags: Clin Nephrol Source Type: research

Impact of left ventricular function on tissue perfusion and renal outcomes in patients with sepsis.
Abstract AIMS: Left ventricular (LV) dysfunction is a predictor of mortality in patients with sepsis. However, it remains uncertain whether LV dysfunction aggravates tissue perfusion, leading to organ failure, or whether it has an independent impact. We investigated the association between LV dysfunction and tissue perfusion, and their impacts on renal outcomes in patients with sepsis. MATERIALS AND METHODS: We retrospectively reviewed 162 adult patients with sepsis who met the Sepsis-3 definition, including 83 (51.2%) with normal LV function, 39 (24.1%) with diastolic dysfunction (septal E/e' ratio> ...
Source: Clinical Nephrology - February 19, 2021 Category: Urology & Nephrology Authors: Moon JI, Shin J, Hwang JH, Kim WY, Kim SH Tags: Clin Nephrol Source Type: research

Solitary renal mass in Waldenstr öm macroglobulinemia.
Solitary renal mass in Waldenström macroglobulinemia. Clin Nephrol. 2021 Feb 09;: Authors: Hamill M, Doyle B, Quinn J PMID: 33560218 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Hamill M, Doyle B, Quinn J Tags: Clin Nephrol Source Type: research

Aplastic crisis secondary to parvovirus B19 primoinfection as an infrequent cause of anemia in an immunocompetent, non-dialysis chronic kidney disease patient.
PMID: 33560219 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Guillen E, Hermida E, Rodas L, Broseta JJ, Cases A Tags: Clin Nephrol Source Type: research

Unusual ischemic kidney injury presenting as slowly declining graft function and successful use of oral desmopressin in a kidney transplant recipient with subclinical central diabetes insipidus.
We present the case of a 36-year-old Japanese female who was diagnosed with subclinical/partial CDI post KT. CDI was caused by a sequela of suprasellar germinoma. Graft function gradually declined without evidence of hypovolemia or hypernatremia, and a kidney biopsy revealed advanced ischemic kidney injury. Although daily oral DDAVP administration did not increase extracellular fluid volume, treatment resulted in a gradual improvement of graft function, and a follow-up transplanted kidney biopsy indicated substantial recovery. PMID: 33560220 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Kaneko S, Usui J, Kawanishi K, Ishii R, Takahashi K, Suzuki H, Saito C, Oda T, Nagata M, Yamagata K Tags: Clin Nephrol Source Type: research

COVID-19 and the kidney: A South African state healthcare experience.
In conclusion, we report a high rate of AKI and poor prognosis in those requiring kidney replacement therapy, a better prognosis than anticipated was found in our chronic dialysis cohort, and high numbers of admissions were required for renal transplant recipients. PMID: 33560221 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Jones ESW, Davidson BJ, Barday Z, Barday Z, Davids MR, Thomson D, Day CA, Hussey H, Vermeulen A, Chothia MY, Nel J, Wearne N Tags: Clin Nephrol Source Type: research

Refractory ascites induced by mycophenolate in a pediatric kidney transplant patient.
Abstract Common side effects of mycophenolate mofetil (MMF) are diarrhea, leukopenia, and infectious complication. The polymorphisms of enzymes affecting MMF clearance could be related to MMF toxicity, and in vitro study revealed that high MMF levels might cause endothelial dysfunction. A 7-year-old Korean male with end-stage renal disease on peritoneal dialysis due to mesangial proliferative glomerulonephritis received a kidney transplantation (KT) from a deceased donor, and immunosuppressive medications including MMF, tacrolimus, and methylprednisolone were started after KT. The patient developed oliguria immedi...
Source: Clinical Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Kim JY, Jang JH, Cho H Tags: Clin Nephrol Source Type: research

Fluctuating creatinine with azacitidine administration.
PMID: 33560223 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Kallis C, Luger S, Hogan J, Geara AS Tags: Clin Nephrol Source Type: research

Living well with kidney disease by patient and care-partner empowerment: Kidney health for everyone everywhere.
Abstract Living with chronic kidney disease (CKD) is associated with hardships for patients and their care-partners. Empowering patients and their care-partners, including family members or friends involved in their care, may help minimize burden and consequences of CKD-related symptoms to enable life participation. There is a need to broaden the focus on living well with kidney disease and re-engagement in life, including emphasis on patients being in control. The World Kidney Day (WKD) Joint Steering Committee has declared 2021 the year of "Living Well with Kidney Disease" in an effort to increase educ...
Source: Clinical Nephrology - February 2, 2021 Category: Urology & Nephrology Authors: Kalantar-Zadeh K, Li PK, Tantisattamo E, Kumaraswami L, Liakopoulos V, Lui SF, Ulasi I, Andreoli S, Balducci A, Dupuis S, Harris T, Hradsky A, Knight R, Kumar S, Ng M, Poidevin A, Saadi G, Tong A, For The World Kidney Day Steering Committee Tags: Clin Nephrol Source Type: research

Efficacy of ferumoxytol versus sodium ferric gluconate in anemia management in outpatient hemodialysis patients: A  prospective cohort study.
CONCLUSION: Both iron products maintained hemoglobin levels, but patients receiving ferumoxytol had lower iron indices and received more blood transfusions compared to patients who received sodium ferric gluconate. PMID: 33433318 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 12, 2021 Category: Urology & Nephrology Authors: El Nekidy WS, El-Masri MM, Kadri A, Soong DC Tags: Clin Nephrol Source Type: research

Tumoral calcinosis due to severe hyperphosphatemia and secondary hyperparathyroidism without vascular calcification in a hemodialysis patient.
We report a case of a 32-year-old man who was undergoing chronic hemodialysis and had hyperphosphatemia and secondary hyperparathyroidism (SHPT) with multiple tumoral calcinosis (TC) lesions refractory to drug therapy. Total parathyroidectomy and autotransplantation were performed, and he recovered from TC within 3 months. Several soft-tissue calcifications were present, but neither computed tomography (CT) before diagnosis nor CT performed 12 months after surgery detected evidence of vascular calcification (VC), despite persistence of hyperphosphatemia. This patient had a high calcium (Ca) × phosphate (P) product an...
Source: Clinical Nephrology - January 12, 2021 Category: Urology & Nephrology Authors: Saito T, Mizobuchi M, Hamada T, Sugiyama M, Miyazawa N, Morikawa T, Matsumoto K, Yoshitake O, Aoki T, Murakami M, Honda H Tags: Clin Nephrol Source Type: research

Diagnostic value of electron microscopy detection using abdominal fat pad biopsy in  systemic amyloidosis.
CONCLUSION: Therefore, preliminary diagnosis of suspected cases can be made by Congo red staining, but the final diagnosis requires an electron microscopic examination. PMID: 33433320 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 12, 2021 Category: Urology & Nephrology Authors: Wang D, Wang Y, Liu B, Liu Y, Sun S Tags: Clin Nephrol Source Type: research

Developing and validating a risk score model for prediction of acute kidney injury in non-ICU hospitalized patients.
Abstract BACKGROUND: Acute kidney injury (AKI) is a common complication in hospitalized patients. Several risk score models have been designed for intensive care unit (ICU) patients. We aim to establish a new risk prediction score for AKI patients in general wards. MATERIALS AND METHODS: All hospitalized ward patients who developed AKI were included in our study. To develop a new prediction score model we used the data collected from 107 patients who developed AKI. We used our prospective validation cohort (122 patients) to develop and validate this prediction score model of AKI. RESULTS: Of 10,243 patie...
Source: Clinical Nephrology - January 12, 2021 Category: Urology & Nephrology Authors: Elrewihby W, Kasem H, Raghib A, Salah Y, Kora M Tags: Clin Nephrol Source Type: research

Acute kidney injury in patients hospitalized with febrile urinary tract infections: A  prospective observational study.
Acute kidney injury in patients hospitalized with febrile urinary tract infections: A prospective observational study. Clin Nephrol. 2020 Dec 23;: Authors: Bobbili RK, Deepanjali S, Rajesh NG, Ramesh A, Medha R Abstract BACKGROUND: Febrile urinary tract infection (fUTI) can be associated with acute kidney injury (AKI). We aimed to study the risk factors for AKI, its pathophysiological categories, and the role of urinary neutrophil gelatinase-associated lipocalin (uNGAL) in differentiating these categories in patients hospitalized with fUTI. MATERIALS AND METHODS: We prospectively studied pat...
Source: Clinical Nephrology - December 23, 2020 Category: Urology & Nephrology Authors: Bobbili RK, Deepanjali S, Rajesh NG, Ramesh A, Medha R Tags: Clin Nephrol Source Type: research

The unresolved epidemic of chronic kidney disease of uncertain origin (CKDu) around the  world: A review and new insights.
The unresolved epidemic of chronic kidney disease of uncertain origin (CKDu) around the world: A review and new insights. Clin Nephrol. 2020 Dec 10;: Authors: Campese VM Abstract EPIDEMIOLOGY: An increasing number of inhabitants of Central America have developed a form of chronic kidney disease of unknown cause, named Mesoamerican nephropathy (MeN). Because similar epidemics have been reported in other parts of the world, such as Sri Lanka, India, Egypt, and Tunisia, this condition is currently called chronic kidney disease of uncertain origin (CKDu). CLINICAL PRESENTATION: This disease is c...
Source: Clinical Nephrology - December 10, 2020 Category: Urology & Nephrology Authors: Campese VM Tags: Clin Nephrol Source Type: research

The clinical impacts of sleep apnea on mortality and allograft function in kidney transplant patients: A meta-analysis.
CONCLUSION: With 14-year follow-up, SA in kidney transplant patients was not associated with worsening clinical and allograft outcomes, such as graft loss, graft failure, and mortality. However, additional observational studies are needed to confirm this finding. PMID: 33287952 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 8, 2020 Category: Urology & Nephrology Authors: Hansrivijit P, Kanderi T, Puthenpura MM, Ghahramani N, Thongprayoon C, Cheungpasitporn W Tags: Clin Nephrol Source Type: research

Going to war with COVID-19: Strategies for SARS-CoV-2 management in the Padua Nephrology and Dialysis Unit's hemodialysis facility.
CONCLUSION: We attribute the low COVID-19 incidence noted so far for patients in our hemodialysis facilities to the early detection and prompt isolation of suspected patients per our specific plan along with the prompt application of preventive measures. PMID: 33250072 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 30, 2020 Category: Urology & Nephrology Authors: Dian S, Simeone M, Rossi B, Scaparrotta G, Fragasso A, Carretta G, Capizzi A, Donato D, Cianci V, Cattelan AM, Calò LA Tags: Clin Nephrol Source Type: research

Atypical hemolytic uremic syndrome with C3 mutation: A case report and literature review.
CONCLUSION: This is the first case of a novel C3 mutation (p.Asn153Asn) in a patient with aHUS. Further studies are needed to confirm the association between this mutation and the CFH level. PMID: 33210998 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 19, 2020 Category: Urology & Nephrology Authors: Liu J, Xiao J, Chen L, Peng Y Tags: Clin Nephrol Source Type: research

Feasibility and outcomes of native arteriovenous fistula in octogenarians.
Abstract INTRODUCTION: While the native arteriovenous fistula (AVF) is the preferred dialysis access, it is a matter of debate for individuals older than 80 years due to reduced primary patency rates. MATERIALS AND METHODS: We initiated a single-center, observational retrospective analysis of adult dialysis patients from January 2015 to December 2018. We included all patients older than 70 years with a minimum of 12 months of follow-up, beginning from the AVF creation. Patients were separated into two groups, octogenarians (> 80 years old) and controls (70 - 79 years old). The primary end po...
Source: Clinical Nephrology - November 19, 2020 Category: Urology & Nephrology Authors: Daulasim A, Seris P, Maheas C, Hude I, Ridel C, Touzot M Tags: Clin Nephrol Source Type: research

Predictors of renal outcomes in crescentic and  mixed class of ANCA-associated glomerulonephritis.
Predictors of renal outcomes in crescentic and mixed class of ANCA-associated glomerulonephritis. Clin Nephrol. 2020 Nov 19;: Authors: You X, Zhang J, Ding X, Zhang J, Zhou Q, Lu G Abstract BACKGROUND: The aim of this study was to investigate the predictors of renal outcomes in crescentic and mixed class of ANCA-associated glomerulonephritis. MATERIALS AND METHODS: We systematically reviewed the medical records of patients with ANCA-associated glomerulonephritis admitted to our hospital from December 2008 to December 2018, and found 30 patients with crescentic and 40 patients with mixed ANCA...
Source: Clinical Nephrology - November 19, 2020 Category: Urology & Nephrology Authors: You X, Zhang J, Ding X, Zhang J, Zhou Q, Lu G Tags: Clin Nephrol Source Type: research

A case of temporary metastatic pulmonary calcification in a patient with hyperparathyroidism on peritoneal dialysis.
CONCLUSION: In a patient on PD, this is the first case of MPC that developed due to acute hypercalcemia, hyperphosphatemia, and dehydration and in which the ectopic pulmonary calcification clearly decreased with optimization of iPTH. PMID: 33211001 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 19, 2020 Category: Urology & Nephrology Authors: Kawase K, Takagi K, Mizuno M, Horie M Tags: Clin Nephrol Source Type: research

Impact of COVID-19 pandemic on CKD outpatient management.
PMID: 33211002 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 19, 2020 Category: Urology & Nephrology Authors: Riccio E, Rizzo M, Rossano R, Pisani A Tags: Clin Nephrol Source Type: research

Acute kidney injury in renal trauma patients.
CONCLUSION: AKI occurred in 60% of cases with RT, and it was significantly associated with high-grade RT. Further studies will be required to confirm this association in other populations, which could lead to an earlier and proactive management of AKI in this setting. PMID: 33211003 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 19, 2020 Category: Urology & Nephrology Authors: Chávez-Iñiguez JS, Ibarra-Estrada MA, Claure-Del Granado R, de Quevedo AA, Maggiani-Aguilera P, Cervantes-Sánchez C, Valdivia-Cerda V, López-Ceja M, Moreno-Alvarado RA, Romo-Rosales FD, García-García G Tags: Clin Nephrol Source Type: research

Clinicopathological profile and outcomes of infection-related glomerulonephritis in adults.
CONCLUSION: IRGN can have an aggressive course in adults, with renal recovery continuing beyond 3 months. IFTA, glomerulosclerosis, IgA deposits, and history of DM are significant negative predictors of clinical outcome, and there is no proven benefit of steroids. PMID: 33191900 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 16, 2020 Category: Urology & Nephrology Authors: Ramineni S, Bandi VK Tags: Clin Nephrol Source Type: research

The effectiveness of a specialized team intervention on prognosis in patients undergoing continuous renal replacement therapy: A retrospective cohort study.
CONCLUSION: In this study, no significant difference was found in patient outcomes between both groups. The results suggest that the CRRT team should have integrated protocols and play a core role in CRRT management. PMID: 33191901 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 16, 2020 Category: Urology & Nephrology Authors: Shimada H, Kataoka Y, Tsunemitsu T, Takeoka H Tags: Clin Nephrol Source Type: research

COVID-19 in chronic hemodialysis patients: A  report of 9 cases in Madrid, Spain.
We describe in depth the clinical, analytical, and radiological details of 9 hemodialysis patients from a single center in Madrid (Spain) diagnosed with COVID-19. Furthermore, we describe and discuss the therapeutic aspects and the patients' outcomes. DISCUSSION: We present one of the first case series of chronic hemodialysis patients with COVID-19. Between March 14 and April 8, 2020, out of 76 prevalent patients in our hemodialysis unit, 9 (11.8%) patients were diagnosed with COVID-19. The most common symptoms were fever (77.8%), asthenia (77.8%), cough (55.6%), and dyspnea (33.3%). A total of 3 patients developed se...
Source: Clinical Nephrology - November 6, 2020 Category: Urology & Nephrology Authors: de la Flor Merino JC, Valga Amado F, Marschall A, Linares Grávalos T, Canepa-Escaro F, Ruiz Cícero E, Albarracín Sierra C, Gallegos Bayas G, Rodeles Del Pozo M Tags: Clin Nephrol Source Type: research

Tocilizumab preserves renal function in rheumatoid arthritis with AA amyloidosis and end-stage kidney disease: Two case reports.
Conclusion: These two cases suggest that tocilizumab may preserve renal function in the setting of end-stage kidney disease and shift the point of no return for RA patients with AA amyloidosis and renal dysfunction. PMID: 33155543 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 6, 2020 Category: Urology & Nephrology Authors: Fukuda M, Sawa N, Hoshino J, Ohashi K, Motoaki M, Ubara Y Tags: Clin Nephrol Source Type: research

A case of extreme hyperphosphatemia due to sodium phosphate enemas successfully treated with sustained low efficiency dialysis.
PMID: 33141015 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 3, 2020 Category: Urology & Nephrology Authors: Di Mario F, Peyronel F, Greco P, Giunta R, Regolisti G, Fiaccadori E Tags: Clin Nephrol Source Type: research

Diffuse "background" monoclonal light chain staining on kidney biopsies in the absence of electron-dense deposits - putting it into perspective: A retrospective cohort study.
CONCLUSION: It is important to recognize and document this finding in the biopsy report, but by itself, it should not be classified as MIg-associated kidney disease even in the face of strong staining intensity. A thorough hematologic work-up is critically important to unmask underlying active myeloma, which many patients may have. But equally important is to avoid inadvertent clone-directed therapy in patients who do not have active myeloma despite the background monoclonal staining. A protocol for periodic monitoring with hematologic and renal parameters to watch for possible malignant transformation is recommend for tim...
Source: Clinical Nephrology - October 23, 2020 Category: Urology & Nephrology Authors: Satoskar AA, Alsanani A, Brodsky SV, Cassol C, Prosek J, Kandukurti K, Ayoub I, Khan A, Devarakonda S, Nadasdy T Tags: Clin Nephrol Source Type: research

Differential effects of peritoneal and hemodialysis on circulating regulatory T cells one month post initiation of renal replacement therapy.
Conclusionː Our study is the first to evaluate longitudinal effects of dialysis on Treg cells in uremia and suggests that PD was more effective in increasing Treg levels 1 month post initiation of dialysis and may contribute to improvement of inflammatory status. Thus, PD may contribute to better outcomes for patients with renal dysfunction, also maintaining homeostasis of peritoneal and renal tissues. PMID: 33074093 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 19, 2020 Category: Urology & Nephrology Authors: Caprara C, Corradi V, Scalzotto E, Frigo AC, Proglio M, Sharma R, Ronco C Tags: Clin Nephrol Source Type: research

Retrospective single-arm cohort study of steroid-dependent minimal change nephrotic syndrome treated with very low-dose rituximab.
Conclusions regarding the best rituximab (RTX) dose to maintain remission and reduce immunosuppressant dependence in adult patients with steroid-dependent minimal change nephrotic syndrome (MCNS) are inconsistent. We report the first low-dose (
Source: Clinical Nephrology - October 19, 2020 Category: Urology & Nephrology Authors: Fujimoto K, Kagaya Y, Kumano S, Fujii A, Tsuruyama Y, Matsuura T, Yamazaki K, Nomura K, Okada K, Okino K, Adachi H, Furuichi K, Yokoyama H Tags: Clin Nephrol Source Type: research

Gender in acute kidney disease: A  narrative review.
Gender in acute kidney disease: A narrative review. Clin Nephrol. 2020 Oct 19;: Authors: Ciarambino T, Para O, Giordano M Abstract Acute kidney injury (AKI) occurs in 3.2 - 9.6% of hospital admissions and in 2.1 - 22.1% of prevalent intensive care unit patients, worldwide. There is a sexual dimorphism in the AKI evolution with implications of sex hormones, endothelin etc. We provide a mini-review on the gender-related differences in the AKI evolution. PMID: 33074095 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 19, 2020 Category: Urology & Nephrology Authors: Ciarambino T, Para O, Giordano M Tags: Clin Nephrol Source Type: research

Long-term renal outcomes of IgA nephropathy presenting with different levels of proteinuria.
CONCLUSION: Patients with proteinuria levels> 0.30 g/d already have a higher risk of doubling of baseline Scr, suggesting the necessity of early intervention in patients presenting with minimal proteinuria. PMID: 32990213 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 28, 2020 Category: Urology & Nephrology Authors: Ai Z, Zhou Q, Huang F, Yang Q, Yu X Tags: Clin Nephrol Source Type: research

Haptoglobin phenotype among patients with  IgA nephropathy: Impact on disease progression and response to treatment.
CONCLUSION: The prevalence of Hp 1-1 phenotype is higher in IgAN patients than in the general population in Israel, and even more than in patients with CKD or subjects on hemodialysis. Patients with Hp 2-2 exhibited a better renal response to the routine therapies. PMID: 32909539 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Habbashe N, Kinaneh S, Hassan K, Armaly Z Tags: Clin Nephrol Source Type: research

The surge in nephrology consultations and inpatient dialysis services during the COVID-19 pandemic.
PMID: 32909540 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Hirsch JS, Uppal NN, Finger M, Barnett R, Fishbane S, Ng JH Tags: Clin Nephrol Source Type: research

An auspicious triumph of recovery from dialysis-requiring acute kidney injury in COVID-19 in a patient with chronic kidney disease, α-1 antitrypsin deficiency, and liver transplant: A case report.
We report a unique case of an immunosuppressed 67-year-old female with homozygous Z-allele mutation A1AT deficiency and liver transplant with baseline chronic kidney disease (CKD) stage IIIa with creatinine of 1 mg/dL and glomerular filtration rate (GFR) of 49 mL/min/1.73m2 ~ 6 months before the presentation. She presented with COVID-19 mediated hypoxic respiratory failure complicated by AKI requiring provisional renal replacement therapy with recovery of kidney function with a new baseline of creatinine of 1.6 - 1.8 mg/dL with GFR of 31 mL/min/1.73m2. PMID: 32909541 [PubMed - as supplied by publisher] ...
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: De Souza L, Nwanji V, Kaur G Tags: Clin Nephrol Source Type: research

Tonsillectomy for IgA nephropathy.
PMID: 32909542 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Geara AS Tags: Clin Nephrol Source Type: research

The case for tonsillectomy in IgA nephropathy.
PMID: 32909543 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Hilburg R, Coppock GM Tags: Clin Nephrol Source Type: research

The case against tonsillectomy in IgA nephropathy.
PMID: 32909544 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: El Kassis Y Tags: Clin Nephrol Source Type: research

Acute interstitial nephritis following treatment with direct-acting antiviral agents in hepatitis C virus-infected patients: A case series.
Abstract Hepatitis C virus (HCV) infection has been associated with several extrahepatic adverse clinical outcomes, including an accelerated rate of loss of kidney function in patients with chronic kidney disease (CKD) and an increased mortality in patients with CKD and kidney failure on hemodialysis. Clinical trials using direct-acting antiviral (DAA) agents have uniformly achieved sustained viral response at 12 weeks (SVR12) rates of> 90% in the general population as well as in patients with CKD/kidney failure on hemodialysis. Sofosbuvir is a DAA prodrug that is phosphorylated into the active metabo...
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Duque JC, Dejman A, Venkat V, Hernandez M, Roth D, Ladino MA Tags: Clin Nephrol Source Type: research

Outcomes of COVID-19-positive kidney transplant recipients: A single-center experience.
PMID: 32909546 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Katz-Greenberg G, Yadav A, Gupta M, Martinez-Cantarin MP, Gulati R, Ackerman L, Belden K, Singh P Tags: Clin Nephrol Source Type: research

Non-obstructive coronary angiogram findings prior to kidney transplantation do not predict post-transplant cardiac events.
CONCLUSION: Dialysis duration, morbid obesity, diabetes control, and tacrolimus levels may represent modifiable risk factors to reduce cardiac events in kidney transplant recipients with non-obstructive cardiac catheterization findings at the time of transplant. PMID: 32909547 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Aziz F, Dhingra R, Anders M, Parajuli S, Mandelbrot D, Djamali A Tags: Clin Nephrol Source Type: research

Peritoneal magnesium elimination and its  clinical relevance in peritoneal dialysis patients.
This study aims to evaluate the peritoneal magnesium elimination characteristics in comparison to other small solutes and the influence of peritoneal transport status. MATERIALS AND METHODS: Peritoneal elimination of magnesium, blood-urea-nitrogen (BUN), and creatinine during a 4-hour peritoneal equilibration test (PET) was assessed in 30 stable PD patients. Absolute magnesium elimination was compared overall and between creatinine transport tertiles. RESULTS: Median age was 61 years, 50% of patients were male, 20% were on automated PD treatment. Serum magnesium was 0.84 mmol/L, and dialysate magnesium at the end...
Source: Clinical Nephrology - September 6, 2020 Category: Urology & Nephrology Authors: Holzmann-Littig C, McCallum W, Heemann U, Renders L, Bietenbeck A, Steubl D Tags: Clin Nephrol Source Type: research

Infection-related glomerulonephritis mimicking lupus nephritis.
This report provides further detail regarding the patient's clinical issues. PMID: 32893813 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 6, 2020 Category: Urology & Nephrology Authors: Alawieh R, Satoskar A, Obole E, Hebert L, Ayoub I Tags: Clin Nephrol Source Type: research

Cobalt alloy hip prostheses and new-onset heart failure in patients with and without chronic kidney disease.
PMID: 32893814 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 6, 2020 Category: Urology & Nephrology Authors: Mavrakanas TA, Kamal O, Charytan DM Tags: Clin Nephrol Source Type: research

Cancer surveillance imaging: Does repeated iodinated contrast exposure impact long-term kidney function?
CONCLUSION: Older age, diabetes, and longer operating time, but not cumulative contrast exposure were found to be associated with worse long-term renal outcomes following surgical resection in patients with early-stage colorectal cancer who survived 3 years. PMID: 32870145 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Heinen J, Hsu M, Selby LV, Russo AE, Nash GM, Jaimes EA, Shingarev R Tags: Clin Nephrol Source Type: research

Safety and efficacy of placement of tunneled hemodialysis catheter without the use of fluoroscopy.
acute;zsi L, Rosivall L Abstract INTRODUCTION: The implantation of acute or chronic vascular accesses for hemodialysis (HD) in end-stage kidney disease patients is a critical skill procedure for nephrologists, with an impact on short- and long-term outcomes of the modality and patient survival. Placement circumstances, however, may depend on the availability of technological support and will likely vary across the world. MATERIALS AND METHODS: We retrospectively reviewed our local experience with ultrasound-guided tunneled dialysis catheter (TDC) insertions but without access to fluoroscopic guidance. Data we...
Source: Clinical Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Pethő Á, Tapolyai M, Szakács-Pál T, Orosz P, Dézsi L, Rosivall L Tags: Clin Nephrol Source Type: research