Cyclosporine benefits patients through more rapid remission of proteinuria in lupus nephritis
(European League Against Rheumatism) The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2019) suggest maintenance therapy with cyclosporine (CYA) results in more rapid remission of proteinuria compared to mycophenolate mofetil (MMF) or azathioprine (AZA) in patients with lupus nephritis. The efficacy of CYA, MMF and AZA in obtaining and maintaining remission of lupus nephritis (LN) is comparable over the long term. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 12, 2019 Category: International Medicine & Public Health Source Type: news
type-2-diabetes-cardiorenal-post-hoc-analysis
New post-hoc analysis shows consistent cardiorenal risk reductions of empagliflozin in a sub-group of adults with type 2 diabetes and chronic kidney disease without overt proteinuriaFindings from a post-hoc analysis of the EMPA-REG OUTCOME ® trial in adults with type 2 diabetes and chronic kidney disease without overt proteinuria were presented at the 79th American Diabetes Association Scientific Sessions® (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - June 10, 2019 Category: Research Source Type: news
Sparsentan Cuts Proteinuria in Rare Kidney Disorder
(MedPage Today) -- Significant reduction in UP/C ratio with higher doses in focal segmental glomerulosclerosis patients (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - October 29, 2018 Category: Urology & Nephrology Source Type: news
Proteinuria Flags Risk for Post-Op Kidney Injury
(MedPage Today) -- Even trace levels of urinary protein tied to elevated rate of acute renal impairment (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - July 5, 2018 Category: Surgery Source Type: news
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models
Progressive kidney diseases are often associated with scarring of the kidney’s filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical for glomerular filtration, and leads to proteinuria and kidney failure. Inherited forms of FSGS are caused by Rac1-activating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal remodeling in podocytes. Whether TRPC5 activity mediates FSGS onset and progression is unknown. We identified a small molecule, AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuri...
Source: ScienceNOW - December 7, 2017 Category: Science Authors: Zhou, Y., Castonguay, P., Sidhom, E.-H., Clark, A. R., Dvela-Levitt, M., Kim, S., Sieber, J., Wieder, N., Jung, J. Y., Andreeva, S., Reichardt, J., Dubois, F., Hoffmann, S. C., Basgen, J. M., Montesinos, M. S., Weins, A., Johnson, A. C., Lander, E. S., Ga Tags: Medicine, Diseases reports Source Type: news
What is the Genetic Inheritance of Alport Syndrome?
Discussion
Alport Syndrome is a genetic disease classically associated with progressive renal disease often leading to end stage renal disease, variable sensory neuronal deafness and ocular findings (perimacular retinopathy).
A. Cecil Alport built on the work of others evaluating families with nephritis and/or hematuria. However he very clearly describes the third generation of a family with an X-linked dominant pattern and also emphasizes the syndrome’s associated deafness.
Alport writes:
“It will be seen from this that nearly all the children of three generations of one family suffer from hematuria or nep...
Source: PediatricEducation.org - August 28, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
The Effects of Short Sleep Duration on Proteinuria and CKD The Effects of Short Sleep Duration on Proteinuria and CKD
Are short sleepers at a higher risk of developing proteinuria and chronic kidney disease?Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 25, 2017 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice
Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin receptor (APLNR, or APJ), is a circulating hormone secreted by the placenta. Elabela but not Apelin knockout pregnant mice exhibit PE-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis. In mice, infusion of exogenous ELA normalizes hypertension, proteinuria, and birth weight. ELA, ...
Source: ScienceNOW - August 17, 2017 Category: Science Authors: Ho, L., van Dijk, M., Chye, S. T. J., Messerschmidt, D. M., Chng, S. C., Ong, S., Yi, L. K., Boussata, S., Goh, G. H.-Y., Afink, G. B., Lim, C. Y., Dunn, N. R., Solter, D., Knowles, B. B., Reversade, B. Tags: Development reports Source Type: news
Anti-preeclampsia hormone discovered
A study published inScience reports on the discovery of a micropeptide that protects pregnant mice from proteinuria and hypertension, two hallmarks of preeclampsia.The Scientist (Source: Society for Endocrinology)
Source: Society for Endocrinology - July 7, 2017 Category: Endocrinology Source Type: news
YAP-mediated mechanotransduction determines the podocytes response to damage
Podocytes are terminally differentiated cells of the kidney filtration barrier. They are subjected to physiological filtration pressure and considerable mechanical strain, which can be further increased in various kidney diseases. When injury causes cytoskeletal reorganization and morphological alterations of these cells, the filtration barrier may become compromised and allow proteins to leak into the urine (a condition called proteinuria). Using time-resolved proteomics, we showed that podocyte injury stimulated the activity of the transcriptional coactivator YAP and the expression of YAP target genes in a rat model of g...
Source: Signal Transduction Knowledge Environment - April 11, 2017 Category: Science Authors: Rinschen, M. M., Grahammer, F., Hoppe, A.-K., Kohli, P., Hagmann, H., Kretz, O., Bertsch, S., Höhne, M., Göbel, H., Bartram, M. P., Gandhirajan, R. K., Krüger, M., Brinkkoetter, P.-T., Huber, T. B., Kann, M., Wickström, S. Tags: STKE Research Articles Source Type: news
Maternal Smoking During Pregnancy Linked to Child Proteinuria Maternal Smoking During Pregnancy Linked to Child Proteinuria
Women who smoke during pregnancy may be more likely to have children with kidney damage than mothers who steer clear of cigarettes, a study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 30, 2016 Category: Consumer Health News Tags: Pediatrics News Source Type: news
Smoking in Pregnancy Tied to Kidney Damage in Kids
THURSDAY, Dec. 22, 2016 -- Children of mothers who smoke during pregnancy may be at increased risk for kidney damage, a new study warns.
Researchers looked at test results for excessive protein in the urine (proteinuria) -- which is a sign of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 22, 2016 Category: Journals (General) Source Type: news
Dual-Pathway Inhibitor Targets Glomerular Disease Dual-Pathway Inhibitor Targets Glomerular Disease
A hypertension drug might benefit patients with primary focal segmental glomerulosclerosis, a rare kidney disease characterized by proteinuria, suggest early results from the DUET trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 28, 2016 Category: Consumer Health News Tags: Nephrology News Source Type: news
Three risk factors suggest a reduction in healthy renal function in patients with diabetes
Patients with diabetes and suffering from acute kidney injury (AKI), proteinuria and uncontrolled blood sugar experience a sharp reduction in the number of years they have healthy renal function before being forced onto dialysis, according to researchers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 21, 2016 Category: Science Source Type: news
Three risk factors suggest a reduction in healthy renal function in patients with diabetes
(University of Cincinnati Academic Health Center) Patients with diabetes and suffering from acute kidney injury, proteinuria and uncontrolled blood sugar experience a sharp reduction in the number of years they have healthy renal function before being forced onto dialysis, according to researchers at the University of Cincinnati College of Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2016 Category: Global & Universal Source Type: news
