type-2-diabetes-cardiorenal-post-hoc-analysis

New post-hoc analysis shows consistent cardiorenal risk reductions of empagliflozin in a sub-group of adults with type 2 diabetes and chronic kidney disease without overt proteinuriaFindings from a post-hoc analysis of the EMPA-REG OUTCOME ® trial in adults with type 2 diabetes and chronic kidney disease without overt proteinuria were presented at the 79th American Diabetes Association Scientific Sessions®
Source: Boehringer Ingelheim Corporate News - Category: Research Source Type: news

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Limited evidence has indicated that addition of a steroidal mineralocorticoid receptor antagonist (MRA) to the standard of care reduces proteinuria in patients with diabetic kidney disease (DKD); however, ther...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Conclusion: eGFR equations incorporating cystatin C are superior to eGFR based on creatinine alone for detecting kidney injury in the early stage. The independent association between cystatin C and glomerular classifications might contribute to it. PMID: 31636737 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
This study aimed to clarify the renal status in elderly patients with type 2 diabetes.Participants and methodsThere were 978 patients with type 2 diabetes who were classified into three groups: Group 1 (aged
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Up to 50% of patients with type 2 diabetes have chronic kidney disease (CKD) [1], characterized by steady decline in kidney function leading to end stage renal disease (ESRD). To monitor kidney function, to classify the stages and to decide the treatment, estimated glomerular filtration rate (eGFR) is commonly used. Indication of renal replacement is always based on eGFR, not albuminuria or proteinuria. Therefore, it is crucial to assess eGFR, followed by identifying and treating at-risk patients for progressive kidney disease.
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Conclusions– Serum uric acid significantly predicted proteinuria in both genders. Moreover, in women with type 2 diabetes and stages 1 and 2 CKD, while the association between eGFR and proteinuria was lost, serum uric acid level was independently correlated with the presence of proteinuria.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
CONCLUSION: The association of normoalbuminuria is common in DKD. The decline of renal function is slower in normoalbuminuria; however, the risk factors, clinical progression, and renal pathology in these patients need to be further explored.
. PMID: 31198168 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
Conclusions: The data we present here support the need to implement routine kidney biopsies in normoalbuminuric diabetic subjects in the early stages of CKD. Such strategy may help to improve risk stratification in diabetic patients and guide therapeutic decisions during the early stages of the disease.Am J Nephrol
Source: American Journal of Nephrology - Category: Neurology Source Type: research
Abstract BACKGROUND: In the absence of a histological diagnosis, persistent albuminuria is globally accepted as the main diagnostic criteria for diabetic kidney disease (DKD). METHODS: In the present retrospective study, we evaluated data from an Italian cohort of 42 deceased diabetic donors (mainly with type 2 diabetes). Using the kidney biopsies obtained at the time of donation to evaluate single or double allocation based on Karpinski score, we determined the prevalence of histological lesions attributable to diabetes. RESULTS: All 42 donors presented with proteinuria in the normal range and an estima...
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
Inflammasome-driven release of interleukin(IL)-1β is a central element of many forms of sterile inflammation and has been evident to promote the onset and progression of diabetic kidney disease. We microdissected glomerular and tubulointerstitial samples from kidney biopsies of patients with diabetic kidney disease and found expression of IL-1β mRNA. Immunostaining of such kidney biopsies across a broad spectrum of diabetic kidney disease stages revealed IL-1β positivity in a small subset of infiltrating immune cell. Thus, we speculated on a potential of IL-1β as a therapeutic target and neutralizing th...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we investigated the antihypertensive effect and underlying mechanisms of P. asiatica L. seeds extract (PASE) in spontaneously hypertensive rat (SHR). Male SHRs were treated with 2.5 mg/kg of fosinopril (FOS) and 400 mg/kg of PASE orally per day for once or 12 weeks. SHR or Wistar-Kyoto rats (WKY) receiving vehicle (distilled water) was used as control. The results demonstrated systolic, diastolic, and mean blood pressures (SBP, DBP, and MBP) were significantly lowered after single and long-term intragastric administration of PASE. The cardiac and aortic index and collagen accumulation were improved in the PA...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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