Meta-analysis: Efficacy and safety of dual blockade of the renin-angiotensin system
The objective of the current systematic review and meta-analysis was to compare the long term efficacy of dual RAS blockade (any two of ACE inhibitors, angiotensin receptor blockers, or aliskiren) with monotherapy, and to evaluate adverse events in patients receiving dual therapy compared with monotherapy. A systematic literature search (PubMed, Embase, Cochrane central register of controlled trials; Jan 1990-Aug 2012; no language restriction) identified 33 RCTs (total n=68,405; 71% men) reporting the outcomes of ... (Source: NeLM - Cardiovascular Medicine)
Source: NeLM - Cardiovascular Medicine - January 29, 2013 Category: Cardiology Source Type: news
IGFBP2 predicts renal function in diabetes
This study by Narayanan and colleagues points towards a potential new clinical biomarker for the long-term outcome of diabetic kidney disease. The IGF family of proteins has been repeatedly implicated in the development of diabetic nephropathy, a major complication of diabetes and the most common end-stage renal disease. In a cohort of 436 type 2 diabetics, Narayanan and colleagues found that a high IGFBP2 concentration at baseline was associated with a decreased glomerular filtration rate over an 8-year period and an increase in proteinuria, indicative of longitudinal deterioration in renal function. Narayanan et al. (201...
Source: Society for Endocrinology - January 8, 2013 Category: Endocrinology Source Type: news
Preeclampsia: Pathophysiology, Management, and Maternal and Fetal Sequelae
Preeclampsia is a unique, complicated problem of pregnancy that is prevalent worldwide. The maternal effects of severe disease may involve multiple organ systems. Consequences of disease for the infant include possible prematurity, fetal growth restriction, placental abruption, or intrauterine fetal demise. In addition, long-term effects of disease have been studied in both mothers and children. Although the exact cause of preeclampsia is not fully understood, increasing evidence points to abnormal placentation and an imbalance of antiangiogenic factors. Specifically, soluble Fms-like tyrosine kinase-1 has been investigate...
Source: NeoReviews recent issues - January 1, 2013 Category: Pediatrics Authors: McDonnold, M., Olson, G. Tags: Fetus and Newborn Infant Articles Source Type: news
KCA-ASCO Young Investigator Award
KCA and the and the ASCO Grants Selection Committee announce the selection of the 2007 Young Investigator Award:Patricia Tang, MD, Princess Margaret HospitalAbstractWith the advent of anti-angiogenic therapies (AAT) for cancer treatment, a number of adverse effects have been identified in patients; importantly these include proteinuria (due to disruption of the glomerular filtration barrier) and hypertension. Hypertension appears to be a class effect of AAT, whereas proteinuria has been reported with bevacizumab, VEGF Trap, and AZD2171. The physiological mechanisms underlying the hypertension and pr...
Source: Kidney Cancer Association - March 4, 2007 Category: Urology & Nephrology Source Type: news
KCA-ASCO Young Investigator Award
KCA and the and the ASCO Grants Selection Committee announce the selection of the 2007 Young Investigator Award:
Patricia Tang, MD, Princess Margaret Hospital
Abstract
With the advent of anti-angiogenic therapies (AAT) for cancer treatment, a number of adverse effects have been identified in patients; importantly these include proteinuria (due to disruption of the glomerular filtration barrier) and hypertension. Hypertension appears to be a class effect of AAT, whereas proteinuria has been reported with bevacizumab, VEGF Trap, and AZD2171. The physiological mechanisms underlying the hypertension ...
Source: Kidney Cancer Association - March 4, 2007 Category: Urology & Nephrology Source Type: news
KCA-ASCO Young Investigator Award
KCA and the and the ASCO Grants Selection Committee announce the selection of the 2007 Young Investigator Award:Patricia Tang, MD, Princess Margaret HospitalAbstractWith the advent of anti-angiogenic therapies (AAT) for cancer treatment, a number of adverse effects have been identified in patients; importantly these include proteinuria (due to disruption of the glomerular filtration barrier) and hypertension. Hypertension appears to be a class effect of AAT, whereas proteinuria has been reported with bevacizumab, VEGF Trap, and AZD2171. The physiological mechanisms underlying the hypertension and pr...
Source: Kidney Cancer Association - March 4, 2007 Category: Urology & Nephrology Source Type: news
