Meta-analysis: Efficacy and safety of dual blockade of the renin-angiotensin system

The objective of the current systematic review and meta-analysis was to compare the long term efficacy of dual RAS blockade (any two of ACE inhibitors, angiotensin receptor blockers, or aliskiren) with monotherapy, and to evaluate adverse events in patients receiving dual therapy compared with monotherapy. A systematic literature search (PubMed, Embase, Cochrane central register of controlled trials; Jan 1990-Aug 2012; no language restriction) identified 33 RCTs (total n=68,405; 71% men) reporting the outcomes of ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news