PPIs may affect responses to atezolizumab in patients with urothelial cancer
(American Association for Cancer Research) Proton pump inhibitor (PPI) use was associated with worse outcomes in patients with urothelial cancer treated with the immunotherapeutic atezolizumab (Tecentriq), compared with patients who did not use PPIs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

PPI Use Is Negative Prognostic Marker in Urothelial Cancer
WEDNESDAY, Sept. 16, 2020 -- For patients with advanced urothelial cancer treated with atezolizumab, proton pump inhibitor (PPI) use is a negative prognostic marker, according to a study published online Sept. 15 in Clinical Cancer Research. Ashley... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 16, 2020 Category: Pharmaceuticals Source Type: news

If PPIs Are Onboard, Atezolizumab May Not Work for Bladder Cancer If PPIs Are Onboard, Atezolizumab May Not Work for Bladder Cancer
Your patients with atezolizumab-treated bladder cancer may not benefit if they are on a PPI.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - September 15, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Stop the PPI to Lower COVID-19 Risk? Stop the PPI to Lower COVID-19 Risk?
A patient wants to stop taking her proton pump inhibitor because she's heard that it increases risk for COVID. What would you recommend?Medscape Family Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 19, 2020 Category: Consumer Health News Tags: Family Medicine/Primary Care Article Source Type: news

PPIs and COVID-19 Risk: A Closer Look at the Data PPIs and COVID-19 Risk: A Closer Look at the Data
Dr Darrell Gray discusses the strengths, limitations, and takeaways from this important new study.Medscape Gastroenterology (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 30, 2020 Category: Gastroenterology Tags: Gastroenterology Commentary Source Type: news

Risk for COVID-19 Increased for Adults Taking PPIs
FRIDAY, July 10, 2020 -- Adults taking proton pump inhibitors (PPIs) have an increased risk for having a positive COVID-19 test, with evidence of a dose-response relationship, according to a study published online July 7 in preprint format in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 10, 2020 Category: Pharmaceuticals Source Type: news

Coronavirus: Heartburn and indigestion drugs may increase risk
A new study found from Cedar-Sinai in Los Angeles found those who took PPIs once daily had a 2.15 times greater risk of contracting COVID-19 compared to those not taking the medication. (Source: the Mail online | Health)
Source: the Mail online | Health - July 8, 2020 Category: Consumer Health News Source Type: news

Drug-Drug Interactions to Avoid in Patients With GI Cancer Drug-Drug Interactions to Avoid in Patients With GI Cancer
Patients with gastrointestinal tumors can have potentially life-threatening complications from drug-drug interactions, including, for example, reactions between PPIs and cepacitabine.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 8, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Popular Heartburn Drugs Linked to Heightened COVID-19 Risk
A popular form of heartburn medication may increase a person’s risk of developing COVID-19, according to a new study, lengthening the already long list of risk factors for the virus. In the study, published Tuesday in pre-print form in the American Journal of Gastroenterology, scientists led by Cedars-Sinai Medical Center’s Dr. Brennan Spiegel conducted an online survey involving more than 86,000 people. Among them, more than 53,000 reported abdominal pain or discomfort, acid reflux, heartburn or regurgitation, and answered questions about the medications they took to relieve those symptoms. Of those, more than...
Source: TIME: Health - July 7, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

The SHOCKING truth about antacids and their effect on your gut health
(Natural News) Acid-reducing agents (ARAs) like antacids and proton pump inhibitors (PPIs) are some of the most common medications prescribed for the treatment of heartburn. A recent study published in the Journal of Clinical Biochemistry and Nutrition found that long-term use of PPIs leads to a decrease in the amount of Faecalibacterium, one of the most beneficial bacteria in the human... (Source: NaturalNews.com)
Source: NaturalNews.com - June 18, 2020 Category: Consumer Health News Source Type: news

Proton Pump Inhibitor Therapy May Up Fracture Risk in Children
THURSDAY, April 2, 2020 -- Proton pump inhibitors (PPIs) taken for acid reflux may lead to an increased risk for fractures in children and adolescents, according to a study published online March 12 in the Journal of Pediatric Gastroenterology and... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 2, 2020 Category: Pharmaceuticals Source Type: news

Proton Pump Inhibitors and Dementia
Hospitals can be dangerous places for older adults. One of these dangers is inappropriate medications — the most common of which is proton pump inhibitors (PPIs). Patients who are discharged taking a PPI often continue to receive it after their admission to a skilled nursing facility. But care needs to be taken: if the PPI is inappropriate, it must be discontinued. As this article highlights, PPIs have many risks to be considered when assessing their continued use with long-term care patients. (Source: Caring for the Ages)
Source: Caring for the Ages - April 1, 2020 Category: Health Management Authors: Sanaz MoharramZadeh, Nader Tavakoli, Amrit Parhar Source Type: news

Fracture Risk Appears Higher With PPIs Than With H2RAs Fracture Risk Appears Higher With PPIs Than With H2RAs
Proton-pump inhibitors (PPIs) appear to carry a higher risk of bone fractures than histamine-2 receptor antagonists (H2RAs), according to two new studies, one in South Korean women and one in kidney-transplant recipients in the U.S.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - March 30, 2020 Category: Orthopaedics Tags: Family Medicine/Primary Care News Source Type: news

The Effects of PPIs on the Microbiome of the Digestive Tract The Effects of PPIs on the Microbiome of the Digestive Tract
Using evidence from next-generation sequencing studies, this review examined the association of PPIs with alterations to gut microbiota. What are the implications of PPI-induced dysbiosis?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 30, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Proton Pump Inhibitors May Up Fracture Risk in Children
WEDNESDAY, March 25, 2020 -- Proton pump inhibitor (PPI) use in children is associated with a small but significant increased risk for any fracture, according to a study published online March 16 in JAMA Pediatrics. Yun-Han Wang, from the Karolinska... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 25, 2020 Category: Pharmaceuticals Source Type: news

Use of PPIs Tied to Cognitive Issues in Breast Cancer Survivors
Concentration, memory problems reported in breast cancer patients at different stages of survivorship (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 3, 2020 Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Gynecology, Internal Medicine, Neurology, Oncology, Pharmacy, Journal, Source Type: news

Use of PPIs Tied to Cognitive Issues in Breast Cancer Survivors
TUESDAY, March 3, 2020 -- Use of acid reflux drugs (proton pump inhibitors [PPIs]) during and after cancer treatment may be tied to impaired memory and concentration in breast cancer survivors, according to a study recently published in the Journal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 3, 2020 Category: Pharmaceuticals Source Type: news

The Risks of Proton Pump Inhibitors During Pregnancy The Risks of Proton Pump Inhibitors During Pregnancy
Questions remain concerning the safety of PPI use during pregnancy. This meta-analysis assessed the risk of adverse neonatal outcomes associated with maternal intake of PPIs.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 2, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Could Heartburn Meds Lead to Drug-Resistant Germs?
The findings do not prove that PPIs -- which include popular brands such as Prilosec (omeprazole), Prevacid (lansoprazole) and Nexium (esomeprazole) -- are the cause, experts said.         But they are the latest to raise safety questions about the top-selling prescription and over-the-counter medicines. (Source: WebMD Health)
Source: WebMD Health - February 25, 2020 Category: Consumer Health News Source Type: news

GI-Bleeding Prophylaxis Benefits Higher-Risk Critically Ill Patients GI-Bleeding Prophylaxis Benefits Higher-Risk Critically Ill Patients
Prophylaxis with proton-pump inhibitors (PPIs) or histamine-2-receptor antagonists (H2RAs) significantly reduces gastrointestinal bleeding in higher-risk critically ill patients, but not in patients at low risk of bleeding, according to a systematic review and network meta-analysis.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 27, 2020 Category: Intensive Care Tags: Gastroenterology News Source Type: news

Ben-Gurion University researchers slash pre-drug screening time from years to days
(American Associates, Ben-Gurion University of the Negev) 'Our new approach will increase the understanding of the mechanisms and evolutionary origins of specific PPIs, and facilitate the rational design of specific inhibitors that can discriminate between structurally similar protein targets,' says Professor Niv Papo of BGU's Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute for Biotechnology in the Negev (NIBN). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 22, 2020 Category: Cancer & Oncology Source Type: news

Low-Value PPI Prescriptions Among Older Adults Low-Value PPI Prescriptions Among Older Adults
Older adults are particularly vulnerable to adverse events associated with PPIs. How prevalent is the prescribing of potentially low-value PPI prescriptions to adults 65 and older?Journal of the American Geriatrics Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 14, 2020 Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news

Half of Patients on PPIs for GERD Still Have Persistent Symptoms
TUESDAY, Dec. 24, 2019 -- Gastroesophageal reflux disorder (GERD) symptoms are common, and more than half of patients taking daily proton pump inhibitor (PPI) therapy continue to experience persistent symptoms, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 24, 2019 Category: Pharmaceuticals Source Type: news

Do PPIs Increase the Risk for Renal Damage or Mortality? Do PPIs Increase the Risk for Renal Damage or Mortality?
Dr Tejas Desai looks into the latest analysis on the potential adverse effects of proton pump inhibitors and asks whether de-escalation measures should be implemented.Medscape Nephrology (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - December 23, 2019 Category: Gastroenterology Tags: Nephrology Viewpoint Source Type: news

Continuous PPI Use May Increase Risk for Acute Gastroenteritis
WEDNESDAY, Nov. 27, 2019 -- Continuous use of proton pump inhibitor (PPI) therapy is associated with an increased risk for acute gastroenteritis (AGE) during winter epidemic periods with peak circulation of enteric viruses, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 27, 2019 Category: Pharmaceuticals Source Type: news

Prescription antacids may increase risk for stomach infections
Stomach acid-reducing drugs known as proton pump inhibitors, or PPIs, nearly doubled people's risk for developing an intestinal viral infection in a recent study -- particularly in those 45 years of age and older. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 27, 2019 Category: Consumer Health News Source Type: news

Study Finds No Support for Purported Side Effects of PPIs Study Finds No Support for Purported Side Effects of PPIs
Proton-pump inhibitor (PPI) use is not associated with an increased risk of dementia, pneumonia or intestinal infections, and an association with chronic kidney disease (CKD) was likely due to residual confounding, new research suggests.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - November 15, 2019 Category: Intensive Care Tags: Gastroenterology News Source Type: news

PPIs Tied to Infections in Children With Normal CYP2C19 Function PPIs Tied to Infections in Children With Normal CYP2C19 Function
Proton pump inhibitor (PPI) therapy is associated with higher infection rates in children with normal CYP2C19 function, with infections occurring in 40% of such infants in a retrospective study.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - November 10, 2019 Category: Pathology Tags: Pediatrics News Source Type: news

PPIs: Placing Putative Adverse Effects in Proper Perspective PPIs: Placing Putative Adverse Effects in Proper Perspective
Are doctors modifying PPI therapy based on solid scientific evidence? Most serious adverse effects attributed to PPIs are based on observational data.Current Opinion in Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 30, 2019 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Surgery Best Option in the Uncommon Case When PPIs Fail to Stem Heartburn Surgery Best Option in the Uncommon Case When PPIs Fail to Stem Heartburn
When heartburn is refractory to proton-pump inhibitor (PPI) treatment, antireflux surgery is a better option than reflux-reducing medication such as baclofen or treatment with neuromodulators, a new clinical trial shows.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - October 18, 2019 Category: Surgery Tags: Gastroenterology News Source Type: news

Surgery May Be Best Option for Some With Refractory Heartburn
WEDNESDAY, Oct. 16, 2019 -- In patients who truly have proton pump inhibitor (PPI)-refractory heartburn, including those with reflux hypersensitivity, surgery may be the best treatment option, according to a study published in the Oct. 16 issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 16, 2019 Category: Pharmaceuticals Source Type: news

Sepsis in patients with cirrhosis awaiting liver transplantation: new trends and management
Bacterial infections are more frequent and severe in patients with advanced liver disease and, therefore, in liver transplant candidates. The increased risk of infection in these patients parallels the severity of the immune dysfunction associated with cirrhosis, featured by systemic inflammation and progressive immunodeficiency. Other factors contribute to this risk, such as genetic polymorphisms, proton-pump inhibitor overuse, the numerous invasive procedures and hospitalizations these patients go through, or the immunosuppressive effects of malnutrition or alcohol abuse. Bacterial infections have a great impact on disea...
Source: Current Awareness Service for Health (CASH) - September 19, 2019 Category: Consumer Health News Source Type: news

H. pylori eradication linked to reduced risk of gastric cancer
Gastric cancer incidence and death half as likely over 22 years after short-term H. pylori treatment Related items fromOnMedica Antivirals cut liver cancer risk after hepatitis C Statins might not cut colorectal cancer risk after all Antibiotics, H2RAs and PPIs linked to child obesity Long-term use of PPIs linked to doubling in stomach cancer risk Taking aspirin with a PPI reduces risk of oesophageal cancer (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 12, 2019 Category: UK Health Source Type: news

36% of proton pump inhibitor prescriptions for older adults may be unneeded
FINDINGSOne in eight older adults was prescribed proton pump inhibitor drugs, which are used to treat gastric ulcers or to prevent gastrointestinal bleeding in those taking blood thinners. About 36 percent of those prescriptions were potentially unnecessary, a study found, primarily because people took them far longer than the often-recommended eight weeks.BACKGROUNDOlder Americans frequently receive  low-value care, which is care that has no net benefit to the individual and has the potential to harm them. Low-value care contributes significantly to higher health costs. Most people are unaware of the potential toxici...
Source: UCLA Newsroom: Health Sciences - September 5, 2019 Category: Universities & Medical Training Source Type: news

Proton Pump Inhibitor Use in Infants and Children Proton Pump Inhibitor Use in Infants and Children
PPIs are approved for use in pediatric patients, but these drugs have been associated with some potentially serious adverse effects. Find out what there is to know.Pediatric Pharmacotherapy (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - August 22, 2019 Category: Allergy & Immunology Tags: Pediatrics Journal Article Source Type: news

Researchers Weigh Benefits, Risks of PPIs
PPIs, or proton pump inhibitors, are among the most common prescription drugs and are used to treat acid reflux, heartburn, indigestion, gastroesophageal reflux disease (GERD), and stomach ulcers. (Source: WebMD Health)
Source: WebMD Health - July 31, 2019 Category: Consumer Health News Source Type: news

Taking heartburn pills DOUBLES your risk of developing an allergy
Researchers in Austria studied the health records of more than 8million people, finding that patients on drugs like PPIs often returned to their doctor to get anti-allergy drugs. (Source: the Mail online | Health)
Source: the Mail online | Health - July 30, 2019 Category: Consumer Health News Source Type: news

Stomach acid-reducing drugs may raise risk of future allergies – study
Lead scientist hopes findings raise awareness about proton-pump inhibitors ’ side-effectsPrescription medicines to reduce stomach acid are associated with an increased risk of developing allergies, according to a study.The research suggests people prescribed proton-pump inhibitors (PPIs) are twice as likely to be prescribed anti-allergy drugs in future years.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - July 30, 2019 Category: Science Authors: Anna Ploszajski Tags: Medical research Drugs Science Health Society Source Type: news

PPIs Appear Largely Safe in Multiyear Trial PPIs Appear Largely Safe in Multiyear Trial
Proton pump inhibitors were not associated with any adverse event when used for three3 years, except for an increased risk for enteric infections, new findings show.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 22, 2019 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Brief nurse-led educational support plus alginates can wean patients off PPIs
And avoid potential long-term health risks and mounting prescription costs, say researchers Related items fromOnMedica Doctors welcome drop in Scotland ’s alcohol consumption Not so ‘smart’ drugs MHRA tightens licence restrictions on valproate for women Marijuana legalisation linked to rise in abuse and car crashes TB could be cured by four months ’ treatment in many patients (Source: OnMedica Latest News)
Source: OnMedica Latest News - July 17, 2019 Category: UK Health Source Type: news

H pylori Raises Phosphate Binder Pill Burden in Dialysis H pylori Raises Phosphate Binder Pill Burden in Dialysis
If those with Helicobacter pylori don't take a proton pump inhibitor or sodium bicarbonate, they have a higher phosphate binder pill burden, researchers report, between six and nine tablets a day.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 20, 2019 Category: Consumer Health News Tags: Nephrology News Source Type: news

FDA Drug Safety Communication: Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors
Update: 3/23/2011 FDA has determined an osteoporosis and fracture warning on the over-the-counter (OTC) proton pump inhibitor (PPI) medication “Drug Facts” label is not indicated at this time. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 19, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Heartburn Drugs Again Tied to Fatal Risks
Research in recent years has linked long-term use of drugs called proton pump inhibitors (PPIs) to increased risks of various diseases and premature death. These latest findings point to the specific causes of death. (Source: WebMD Health)
Source: WebMD Health - June 6, 2019 Category: Consumer Health News Source Type: news

Large placebo-controlled trial confirms safety of proton pump inhibitors (PPIs)
(American Gastroenterological Association) For patients taking proton pump inhibitors (PPIs) to treat gastroesophageal disease (GERD) or other acid-related conditions, new research puts safety concerns to rest. In a large, multi-year, randomized trial studying the safety of proton pump inhibitors (PPIs), researchers find no evidence to support claims that PPIs cause serious health issues such as pneumonia, chronic kidney disease, diabetes and dementia. This research is published in Gastroenterology, the official journal of the American Gastroenterological Association, as an article in press. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 6, 2019 Category: International Medicine & Public Health Source Type: news

Excess Cause-Specific Mortality Tied to Chronic Proton Pump Inhibitor Use
FRIDAY, May 31, 2019 -- Taking proton pump inhibitors (PPIs) is associated with an excess of cause-specific mortality, according to a study published online May 30 in The BMJ. Yan Xie, M.P.H., from St. Louis Health Care System, and colleagues... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 31, 2019 Category: Pharmaceuticals Source Type: news

Heartburn drugs linked to fatal heart and kidney disease, stomach cancer
(Washington University in St. Louis) A study by researchers at Washington University School of Medicine in St. Louis and Veterans Affairs St. Louis Health Care System has linked long-term use of such popular heartburn drugs -- called proton pump inhibitors (PPIs) -- to fatal cases of cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. More than 15 million Americans have prescriptions for PPIs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: news

Improper Proton Pump Inhibitor Prescriptions Criticized Improper Proton Pump Inhibitor Prescriptions Criticized
Popularity of the stomach- and intestine-protecting drugs has skyrocketed, but related adverse events, like osteoporotic fractures, C difficile infection, and pneumonia, are problematic.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 22, 2019 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Antibiotics, PPIs Tied to Higher C. Diff Risk in Hospitalized Children
THURSDAY, March 21, 2019 -- Previous antibiotic exposure and use of proton pump inhibitors (PPIs) may be risk factors for Clostridioides (formerly Clostridium) difficile infection (CDI) in hospitalized pediatric patients, according to a review... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 21, 2019 Category: Pharmaceuticals Source Type: news

Antibiotics and PPIs linked to increased risk of infectious diarrhea in children
(Society for Healthcare Epidemiology of America) Prior antibiotic exposure and use of acid suppressing medications known as proton pump inhibitors (PPIs) may increase the risk for hospitalized children to contract dangerous Clostridioides difficile infections, according to a study published today in Infection Control& Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 7, 2019 Category: Infectious Diseases Source Type: news

Slow Medicine: Why Are We Lukewarm About PPIs in the ICU?
(MedPage Today) -- Let's look at the research (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - March 4, 2019 Category: Gastroenterology Source Type: news