New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures

Conclusions:
These new resources offer substantial advances to classical toxicity testing paradigms by including genetically sensitive individuals that may inform toxicity risks for sensitive subpopulations. Both in vivo and complementary in vitro resources provide platforms with which to reduce uncertainty by providing population-level data around biological variability. https://doi.org/10.1289/EHP1274

Received: 25 October 2016
Revised: 19 April 2017
Accepted: 27 April 2017
Published: 15 August 2017
Address correspondence to K.A. McAllister, Program Administrator, Genes, Environment, and Health Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, P.O. Box 12233 (MD EC-21), Research Triangle Park, NC 27709 USA. Telephone: [phone]. Email: [e-mail]
The authors declare they have no actual or potential competing financial interests.
Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [e-mail]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.

Introduction
Environmental scientists worldwide are tasked with assessing health risks of environmental ex...

Source: EHP Research - August 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research