New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures

Conclusions: These new resources offer substantial advances to classical toxicity testing paradigms by including genetically sensitive individuals that may inform toxicity risks for sensitive subpopulations. Both in vivo and complementary in vitro resources provide platforms with which to reduce uncertainty by providing population-level data around biological variability. https://doi.org/10.1289/EHP1274 Received: 25 October 2016 Revised: 19 April 2017 Accepted: 27 April 2017 Published: 15 August 2017 Address correspondence to K.A. McAllister, Program Administrator, Genes, Environment, and Health Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, P.O. Box 12233 (MD EC-21), Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4528. Email: Mcallis2@niehs.nih.gov The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Introduction Environmental scientists worldwide are tasked with assessing health risks...
Source: EHP Research - Category: Environmental Health Authors: Tags: Review Source Type: research

Related Links:

ConclusionsIn this model, compared with IPG SCS or with CMM, Wireless SCS is a superior strategy.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Clinical Research Source Type: research
Hematopoietic stem cell (HSC) attrition is considered the key event underlying progressive BM failure (BMF) in Fanconi anemia (FA), the most frequent inherited BMF disorder in humans. However, despite major advances, how the cellular, biochemical, and molecular alterations reported in FA lead to HSC exhaustion remains poorly understood. Here, we demonstrated in human and mouse cells that loss-of-function of FANCA or FANCC, products of 2 genes affecting more than 80% of FA patients worldwide, is associated with constitutive expression of the transcription factor microphthalmia (MiTF) through the cooperative, unscheduled act...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis. Dysregulated Notch signaling has also been implicated in human disease, including multiple forms of cancer, and represents an emerging therapeutic target. Successful development of such therapeutics requires a detailed understanding of potential on-target toxicities. Here, we identify autosomal dominant mutations of the canonical Notch ligand Jagged1 (or JAG1) as a cause of peripheral nerve disease in 2 unrelated families with the hereditary axonal neuropathy Charcot-Marie-T...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionThe results of this study showed that the pain is more observable in cold temperament group, therefore we can empower the gynecologists, midwives and nurses in this field by practical training for them and accordingly contribute to reduce the use of chemical drugs by women with primary dysmenorrhea as well as increasing their efficacy in daily activities and improving their quality of life and their physical and mental health.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Publication date: Available online 17 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Krishna Prasad Acharya, Niran Adhikari, Muhammad TariqAbstractThe agro-climatic conditions, socio-economic situation, poor sanitation, low hygiene and health standards in Nepal are major contributing factors to the emergence of scrub typhus in Nepal. These outbreaks, along with poor diagnostic facilities, can lead to severe economic losses in a resource-limited country like Nepal. Diseases like avian influenza, leptospirosis, brucellosis, tuberculosis and rabies, that cause heavy socio-economic burden, have received...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
BACKGROUND: Barodontalgia, barometric pressure-induced dental pain, may jeopardize diving/flight safety. The aim of this systematic review was to investigate the rate of barodontalgia among military and civilian divers and aircrews based on previous...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Over 90% of suicides in the West could be diagnosed with mental disorders, while only 50-70% of Chinese suicides had mental disorders. Using data from a case-control study on suicide attempt, we aimed to compare characteristics and risk factors between sui...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Rural and Agricultural Issues Source Type: news
We examined as...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Adolescence is a key window of vulnerability for depression, the leading cause of disability worldwide. The prevention of depression among young people is therefore of substantial public health importance. A growing body of large-scale data now support...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Unintentional injuries in and around the home are important causes of preventable death and disability among young children globally. In Nepal, there is a lack of data regarding home injuries and home hazards to guide the development of effecti...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
More News: Academies | Acetaminophen | Addiction | African Health | African Sleeping Sickness | Alcoholism | Angola | Biology | Brain | Cancer | Cancer & Oncology | Cardiology | Chemistry | Cholesterol | Chronic Pain | Clinical Trials | Complementary Medicine | Congo Health | Databases & Libraries | Depression | Diabetes | Diets | Disability | Eating Disorders & Weight Management | Ebola | Endocrinology | Environmental Health | Epidemiology | Fluoxetine | France Health | Gastroenterology | Genetics | Green Tea | Guinea Health | Heart | Herbs | History of Medicine | Inflammatory Bowel Disease | Iraq Health | Israel Health | Laboratory Medicine | Liver | Lortab | Men | Metabolic Syndrome | Middle East Health | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Nutrition | Obesity | Occupational Health | Oral Cancer | Overdose | Pain | Pain Management | Papanicolaou (Pap) Smear | Pathology | Physiology | Prozac | Respiratory Medicine | Science | Sleeping Sickness | South Africa Health | Statistics | Stem Cell Therapy | Stem Cells | Study | Substance Abuse | Sudan Health | Syria Health | Toxicology | Training | Tuberculosis | Universities & Medical Training | Urology & Nephrology | Wales Health | Workshops