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Increased acetaminophen related calls to Finnish PIC better reflect acetaminophen sales than serious poisonings - Parry MJ, Isoniemi H, Koivusalo AM, Hoppu K.
OBJECTIVE: Acetaminophen (APAP) or paracetamol is a commonly encountered medicine in poisonings. We studied the changes in APAP related calls to the Finnish poison information centre (FPIC), and serious intoxications, involving hepatotoxicity or death in 2... (Source: SafetyLit)
Source: SafetyLit - August 25, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Orbivan (Butalbital, Acetaminophen, and Caffeine Capsules, USP) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 24, 2017 Category: Drugs & Pharmacology Source Type: news

What Are the Side Effects of Acetaminophen?
Title: What Are the Side Effects of Acetaminophen?Category: Doctor's& Expert's views on SymptomsCreated: 8/4/2017 12:00:00 AMLast Editorial Review: 8/4/2017 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - August 4, 2017 Category: Neurology Source Type: news

FDA Drug Safety Communication: Addition of another concentration of liquid acetaminophen marketed for infants
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 3, 2017 Category: Drugs & Pharmacology Source Type: news

Comprehensive Initiative Has Positive Impact on Opioid Rx
Reductions in all tracked outcomes, including 95 % drop in brand name opioid - acetaminophen products (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - August 1, 2017 Category: Psychiatry Tags: Family Medicine, Geriatrics, Gynecology, Internal Medicine, Emergency Medicine, Neurology, Nursing, Orthopedics, Pharmacy, Psychiatry, Rheumatology, Surgery, Anesthesiology & Pain, Journal, Source Type: news

Potential acetaminophen and opioid overdoses in young children prescribed combination acetaminophen/opioid preparations - Basco WTJ, Garner SS, Ebeling M, Hulsey TC, Simpson K.
INTRODUCTION: Combination preparations of acetaminophen/opioid are the most common opioid form prescribed to children. We tested the hypothesis that dispensed prescriptions of acetaminophen/opioid preparations more appropriately match acetaminophen dosing ... (Source: SafetyLit)
Source: SafetyLit - July 31, 2017 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Public health: acetaminophen (APAP) hepatotoxicity- isn't it time for APAP to go away? - Lee WM.
Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP is capable of causing dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the U.S. alone, as we... (Source: SafetyLit)
Source: SafetyLit - July 26, 2017 Category: International Medicine & Public Health Tags: Commentary Source Type: news

acetaminophen (Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain)
Title: acetaminophen (Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 7/20/2017 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - July 20, 2017 Category: Anesthesiology Source Type: news

When Can a Doctor Help Your Back Pain?
Treatment TermsBack pain TagsBack pain Sub-Title Answers to Common Back Pain Questions Overview More than eight in 10 people will experience back pain at some point in their lives. In most cases, the pain goes away over time. If your back pain is severe or does not improve, you may need medical care. Here are answers to some common questions about back pain and tips on when to seek help. Content Blocks Header Why Does My Back Hurt? ContentThere are various reasons why your back can hurt, including muscle pain, disc pain, joint pain, or nerve pain. In most cases, these are not harmful or dangerous. “There are...
Source: dukehealth.org: Duke Health News - June 28, 2017 Category: Consumer Health News Authors: mf205 at duke.edu Source Type: news

Tramadol with or without paracetamol (acetaminophen) for cancer pain
This Cochrane Review finds very low quality data suggesting tramadol produced pain relief in some adults with pain due to cancer and is not as effective as morphine. There is no evidence for children. The place of tramadol in managing cancer pain and its role as step 2 of the WHO analgesic ladder is unclear. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 28, 2017 Category: Consumer Health News Source Type: news

Does paracetamol taken in pregnancy affect masculinity?
Conclusion Headlines like those in the media about this study are likely to alarm pregnant women who have taken or may need to take paracetamol in pregnancy. While the study's results can't be dismissed altogether, there are three important things to bear in mind: Studies in mice don't always translate into results in humans. The doses of paracetamol that produced the effects in mice were the equivalent of three times higher than the maximum daily dose for adult humans. The pregnant mice were fed paracetamol every day throughout the last two-thirds of their pregnancy. Most pregnant women take paracetamol at the re...
Source: NHS News Feed - June 23, 2017 Category: Consumer Health News Tags: Pregnancy/child Medication Source Type: news

Medical News Today: Prenatal acetaminophen may affect masculinity
New research examines the effects of prenatal exposure to the common painkiller acetaminophen on the behavior and brain structure of adult male mice. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 22, 2017 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news

Lannett Receives Approval For Hydrocodone Bitartrate and Acetaminophen Tablets USP, 5 mg/300 mg, 7.5 mg/300 mg And 10 mg/300 mg
PHILADELPHIA, June 22, 2017 -- (Healthcare Sales & Marketing Network) -- Lannett Company, Inc. (NYSE: LCI) today announced that it received approval from the U.S. Food and Drug Administration (FDA) of its Abbreviated New Drug Application (ANDA) for Hydroc... Biopharmaceuticals, Generics, FDA Lannett, Hydrocodone, Acetaminophen, Vicodin (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 22, 2017 Category: Pharmaceuticals Source Type: news

Acetaminophen: A viable alternative for preventing acute mountain sickness
(Elsevier) Trekking and mountain climbing are quickly growing in popularity, but.one of the challenges that climbers face is acute mountain sickness (AMS). Previous studies have shown that ibuprofen is an effective way to reduce the risk of AMS. Investigators wanted to find out if acetaminophen, a commonly used anti-pain medicine like ibuprofen, would have a comparable effect. They found almost no difference in the performance of both drugs, suggesting that acetaminophen may be another effective prophylactic treatment for AMS. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 19, 2017 Category: International Medicine & Public Health Source Type: news

Allzital (Allzital Butalbital and Acetaminophen Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 5, 2017 Category: Drugs & Pharmacology Source Type: news

Roxicet (Oxycodone and Acetaminophen ) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 5, 2017 Category: Drugs & Pharmacology Source Type: news

Tylox (Oxycodone and Acetaminophen Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 1, 2017 Category: Drugs & Pharmacology Source Type: news

CertaDose, the Revolutionary Children ’s Syringe Can Prevent Accidental Overdoses, Launches on Indiegogo
Denver, Colo. - CertaDose, an innovative syringe that addresses the most common type of medical error in children - medication dosing errors - launched today on Indiegogo. CertaDose is a fast, accurate and safe way to measure children’s medication and helps eliminate dosage errors, which medical experts believe to be the number one killer of children. Emergency Room Doctor Caleb Hernandez developed the CertaDose Syringe to provide a simple method to measure and confirm the correct dose for any infant or child. “Each year, 140,000 children are harmed and about 7,000 children die needlessly due to dosing err...
Source: JEMS Patient Care - May 23, 2017 Category: Emergency Medicine Authors: CertaDose Tags: Patient Care Industry News Source Type: news

CertaDose, the Revolutionary Children ’s Syringe Can Prevent Accidental Overdoses, Launches on Indiegogo
Denver, Colo. - CertaDose, an innovative syringe that addresses the most common type of medical error in children - medication dosing errors - launched today on Indiegogo. CertaDose is a fast, accurate and safe way to measure children’s medication and helps eliminate dosage errors, which medical experts believe to be the number one killer of children. Emergency Room Doctor Caleb Hernandez developed the CertaDose Syringe to provide a simple method to measure and confirm the correct dose for any infant or child. “Each year, 140,000 children are harmed and about 7,000 children die needlessly due to dosing err...
Source: JEMS: Journal of Emergency Medical Services News - May 23, 2017 Category: Emergency Medicine Authors: CertaDose Tags: Patient Care Industry News Source Type: news

Risk prediction of hepatotoxicity in paracetamol poisoning - Wong A, Graudins A.
CONTEXT: Paracetamol (acetaminophen) poisoning is the most common cause of acute liver failure in the developed world. A paracetamol treatment nomogram has been used for over four decades to help determine whether patients will develop hepatotoxicity witho... (Source: SafetyLit)
Source: SafetyLit - May 2, 2017 Category: Global & Universal Tags: Home and Consumer Product Safety Source Type: news

Biologists Are Using Robots and Technology to Battle Alien Plants and Animals
(WASHINGTON) — A robot zaps and vacuums up venomous lionfish in Bermuda. A helicopter pelts Guam’s trees with poison-baited dead mice to fight the voracious brown tree snake. A special boat with giant winglike nets stuns and catches Asian carp in the U.S. Midwest. In the fight against alien animals that invade and overrun native species, the weird and wired wins. “Critters are smart — they survive,” said biologist Rob “Goose” Gosnell, head of U.S. Department of Agriculture’s wildlife services in Guam, where brown tree snakes have gobbled up nearly all the native birds. &ldquo...
Source: TIME.com: Top Science and Health Stories - April 28, 2017 Category: Consumer Health News Authors: Seth Borenstein / AP Tags: Uncategorized Environment onetime technology Source Type: news

Co-ingestion of willow bark tea and acetaminophen associated with fatal infantile fulminant liver failure - Dinakaran D, Bristow E, Armanious H, Garros D, Yap J, Noga M, Sergi C.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - April 26, 2017 Category: Global & Universal Tags: Age: Infants and Children Source Type: news

p53 critical to recovering from acetaminophen overdose
A new study shows that after an acetaminophen overdose, the p53 protein plays a key role in preventing the progression of liver damage and signaling the liver to repair itself. The findings could lead to new treatments for people who overdose on this popular pain reliever and fever reducer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 26, 2017 Category: Science Source Type: news

Unsealed Documents Reveal Prince's Doctor Prescribed Meds For Singer Under Another Name
Opioid painkiller were found in pop star Prince’s home after his sudden death a year ago, and investigators were told that the musician had history of withdrawals “believed to be the result of abuse of prescription medication,” according to court documents unsealed on Monday. According to a search warrant of Prince’s Paisley Park complex outside Minneapolis, investigators found several pills labeled Watson 853 - the identifier for the generic hydrocodone-acetaminophen - in various rooms. A search also turned up other “numerous narcotic controlled substance pills” in various containers, s...
Source: Healthy Living - The Huffington Post - April 17, 2017 Category: Consumer Health News Source Type: news

Hepatotoxicity of paracetamol and related fatalities - Tittarelli R, Pellegrini M, Scarpellini MG, Marinelli E, Bruti V, di Luca NM, Busard ò FP, Zaami S.
Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available over-the-counter as a single formulation or in combination with other substances and, as indicated by the World Health Organiza... (Source: SafetyLit)
Source: SafetyLit - April 11, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Kids' Solid-dose Acetaminophen Products Transition to Single Strength
Manufacturers of pediatric solid-dose acetaminophen products are transitioning to a single strength of 160-mg chewables in the United States, which will be dubbed " Children's. " (Source: AAFP News)
Source: AAFP News - April 7, 2017 Category: Primary Care Source Type: news

Acetaminophen and children: Why dose matters
(Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - March 29, 2017 Category: Consumer Health News Source Type: news

Longer Duration of NSAID, Acetaminophen Use Associated With Hearing Loss in Women
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - March 18, 2017 Category: Orthopaedics Tags: Perspective Source Type: news

"Tampering to death": a fatal codeine intoxication due to a homemade purification of a medical formulation - Fais P, Pigaiani N, Cecchetto G, Montisci M, Gottardo R, Viel G, Pascali JP, Tagliaro F.
Many homemade tamper processes of medical codeine formulations are available on selected "forums" on the Internet, where recreational codeine users claim to be able to purify codeine by removing additives, such as acetaminophen, to avoid or limit adverse e... (Source: SafetyLit)
Source: SafetyLit - March 17, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Percocet (Oxycodone and Acetaminophen) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 15, 2017 Category: Drugs & Pharmacology Source Type: news

Consumer Healthcare Products Association response to Major et al., "Trends in rates of acetaminophen-related adverse events in the United States", Pharmacoepidemiology & Drug Safety, May 2016, 25: 590-8 - Sirois JE.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - March 9, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Response to Consumer Healthcare Products Association letter to "Trend in rates of acetaminophen-related adverse events in the United States" - Pham T, Major JM, Chai G, Moeny D, Wang C, Blum MD.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - March 9, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Lupin launches pain relief drug in US
Lupin said it had received final approval from the US health regulator for its Hydrocodone Bitartrate and Acetaminophen tablets used for providing pain relief. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 9, 2017 Category: Pharmaceuticals Source Type: news

Looking for relief, pregnant women turn to marijuana despite medical advice
According to data from the Centers for Disease Control and Prevention ’s National Vital Statistics Reports, more than one in five U.S. births now occur in states where marijuana is legal. That ’s triggered a concern among health professionals about the use of marijuana by pregnant women.Along with the broader availability of marijuana comes the perception that it is a harmless substance, health professionals say. But pregnant women, who may be seeking relief from a variety of ailments, should be aware of the potential health consequences of marijuana use.To understand how marijuana affects expectant mother...
Source: UCLA Newsroom: Health Sciences - March 2, 2017 Category: Universities & Medical Training Source Type: news

Trezix Capsules (Acetaminophen, Caffeine and Dihydrocodeine Bitartrate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 28, 2017 Category: Drugs & Pharmacology Source Type: news

Safety Risks of Baltic Amber Teething Necklaces and Similar Cultural Practices?
Discussion Amber is fossilized tree resin that is prized for its beautiful colors from deep brown to caramel, yellow, green or even white. It is promoted for its “healing properties” although there is not scientific evidence that supports the many potentiated mechanisms of these properties. One of the most consistent is that amber contains succinic acid which proponents believe is absorbed through the skin and is a pain reliever. Succinic acid was actually first purified from amber in 1546 by a German chemist. Succinic acid in humans is an important part of the Krebs cycle and acts as an important metabolite in...
Source: PediatricEducation.org - February 27, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Duration of Analgesic Use and Risk of Hearing Loss in Women Duration of Analgesic Use and Risk of Hearing Loss in Women
Frequent use of analgesics including aspirin, NSAIDs, and acetaminophen has been associated with a higher risk of hearing loss. How might duration of use impact this risk?American Journal of Epidemiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 22, 2017 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

What Causes Hyperammonemia?
Discussion Reye’s syndrome (RS)is named for Dr. Douglas Reye who along with Drs. G. Morgan and J. Baral described encephalopathy and fatty accumulation and degeneration in children in a 1963 Lancet article. RS usually affects children but can occur at all ages. All organs can be affected but the liver and brain are primarily affected causing liver failure and encephalopathy as toxic metabolites (especially ammonia) accumulate, and intracranial hypertension and cerebral edema occurs. As the ammonia levels begin to rise (> 100 mg/dL) patients lose their appetite, have nausea and emesis and mental status changes whic...
Source: PediatricEducation.org - February 20, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Fight pain naturally with these powerful natural remedies
(Natural News) Every day, millions of people rush to the pharmacy for some over-the-counter (OTC) or prescription pain medication. Most of us who live with the debilitating effects of chronic pain would do almost anything to find relief. While painkillers like ibuprofen, acetaminophen (the active ingredient in Tylenol) or the more addictive opioid drugs can... (Source: NaturalNews.com)
Source: NaturalNews.com - February 13, 2017 Category: Consumer Health News Source Type: news

Do not get a serum acetaminophen level less than 4 hours after an acute ingestion
4 out of 5 stars Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine? Yarema MC et al. Clin Toxicol 2017 Feb;55:102-108. Abstract For decades the decision whether or not to treat acute acetaminophen [APAP] toxicity with N-acetylcysteine (NAC) has been guided by a serum APAP level drawn 4 or more hours after ingestion. The thought was that before 4 hours the level might be misleading because absorption of the drug might not be complete. This paper addresses the question of whether an earlier level can be suffic...
Source: The Poison Review - February 9, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical acetaminophen antidote APAP N-acetylcysteine rumack-matthew nomogram treatment Source Type: news

Charleston Laboratories, Inc. and Daiichi Sankyo, Inc. Receive Complete Response Letter from FDA for NDA for CL-108 (hydrocodone, acetaminophen, promethazine) Tablets
JUPITER, Fla., and PARSIPPANY, N.J., Feb. 3, 2017 /PRNewswire/ -- Charleston Laboratories, Inc., and Daiichi Sankyo, Inc., confirmed today that the U.S. Food and Drug Administration (FDA) has issued a Complete Response Letter (CRL) regarding the New... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - February 3, 2017 Category: Drugs & Pharmacology Source Type: news

Endocet (Oxycodone and Acetaminophen Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 31, 2017 Category: Drugs & Pharmacology Source Type: news

Acetaminophen and Codeine Phosphate Oral Suspension USP (Capital and Codeine) (New - Discontinuation)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 27, 2017 Category: Drugs & Pharmacology Source Type: news

Protein involved in blood clotting stimulates liver repair
A new pathway in the body that stimulates liver repair has been uncovered by researchers. Using an experimental model of high-dosage acetaminophen, the team found that liver injury activated blood clotting, which then stimulated liver repair. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 18, 2017 Category: Science Source Type: news

Protein involved in blood clotting stimulates liver repair
(Michigan State University) A team of Michigan State University researchers, led by James Luyendyk in the College of Veterinary Medicine, has uncovered a new pathway in the body that stimulates liver repair.Using an experimental model of high-dosage acetaminophen, the team found that liver injury activated blood clotting, which then stimulated liver repair.The study is published online in the Journal of Hepatology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 18, 2017 Category: Global & Universal Source Type: news

Oxycodone vs. Vicodin (hydrocodone/acetaminophen)
Title: Oxycodone vs. Vicodin (hydrocodone/acetaminophen)Category: MedicationsCreated: 1/3/2017 12:00:00 AMLast Editorial Review: 1/4/2017 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - January 4, 2017 Category: Anesthesiology Source Type: news

Trezix Capsules (Acetaminophen, Caffeine and Dihydrocodeine Bitartrate) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 30, 2016 Category: Drugs & Pharmacology Source Type: news

Over the counter painkillers linked to hearing loss
In a study of women, longer durations of NSAID and acetaminophen use were associated with slightly higher risks of hearing loss, but duration of Aspirin use was not. (Source: CBC | Health)
Source: CBC | Health - December 23, 2016 Category: Consumer Health News Tags: News/Health Source Type: news

The pain of chronic loneliness can be detrimental to your health
The changes came so gradually that, for a long time, Paula Dutton didn ’t realize she was in trouble. This was just modern life, after all — the cross-country distance from her close-knit family in Philadelphia, the end of a 10-year marriage, the death of one parent and then the other. By the time Dutton retired from her job, she was lonely to a degree that shocked and frightened her.“I just suddenly realized I was all alone and had no one around me and no one I could turn to,” says Dutton, now 71. “I had a lot of pity parties, I can tell you — and with all kinds of anxiety and depressio...
Source: UCLA Newsroom: Health Sciences - December 22, 2016 Category: Universities & Medical Training Source Type: news