Update on herbal and dietary supplement-induced liver injury: current gaps and future directions - Weber S, Gerbes AL.
Drug-induced liver injury (DILI) is a rare but potentially life-threatening condition, which accounts for the majority of acute liver failure cases in the US and EU. Unlike direct hepatoxicity, which is mainly caused by acetaminophen, idiosyncratic DILI is... (Source: SafetyLit)
Source: SafetyLit - October 30, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

FDA Approves Maxigesic IV to be Marketed in the U.S. as Combogesic IV (acetaminophen and ibuprofen) for the Management of Pain
Maxigesic® IV, a potent non-opioid painkiller, to be marketed in the U.S. under the tradename Combogesic® IV Liège, Belgium– 18 OCTOBER 2023 - Hyloris Pharmaceuticals SA (Euronext Brussels: HYL), a specialty biopharma... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - October 18, 2023 Category: Drugs & Pharmacology Source Type: news

Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective - Chiew AL, Isbister GK.
INTRODUCTION: Acetaminophen (paracetamol) is a commonly used analgesic and antipyretic agent, which is safe in therapeutic doses. Acetaminophen poisoning due to self-harm or repeated supratherapeutic ingestion is a common cause of acute liver injury. Acety... (Source: SafetyLit)
Source: SafetyLit - September 19, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Paracetamol (acetaminophen) poisoning: the early years - Prescott LF.
Paracetamol (acetaminophen) was marketed in the 1950s as a non-prescription analgesic/antipyretic without any preclinical toxicity studies. It became used increasingly for self-poisoning, particularly in the UK and was belatedly found to cause acute liver ... (Source: SafetyLit)
Source: SafetyLit - September 18, 2023 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania
Conclusions and practical implications: Nonopioid medications, specifically nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen alone or in combination with acetaminophen, are recommended for managing acute dental pain after 1 or more tooth extractions (that is, simple and surgical) and the temporary management of toothache in children (conditional recommendation, very low certainty). According to the US Food and Drug Administration, the use of codeine and tramadol in children for managing acute pain is contraindicated.  (Source: Dental Technology Blog)
Source: Dental Technology Blog - September 1, 2023 Category: Dentistry Source Type: news

New Guideline for Managing Toothache in Kids New Guideline for Managing Toothache in Kids
NSAIDs with or without acetaminophen can lessen dental pain when definitive treatment is not immediately available, according to new recommendations.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 31, 2023 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Avoid Opioids for Short-Term Dental Pain in Kids, New Guidelines Say
MONDAY, Aug. 28, 2023 -- Children having short-term dental pain from extractions or toothache should not be prescribed opioids but rather manage those aches with over-the-counter ibuprofen and/or acetaminophen, according to new guidelines. The... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 28, 2023 Category: General Medicine Source Type: news

Recommendations Developed for Acetaminophen Poisoning
THURSDAY, Aug. 10, 2023 -- In a consensus statement published online Aug. 8 in JAMA Network Open, recommendations are presented for the management of patients with acetaminophen poisoning. Richard C. Dart, M.D., Ph.D., from the University of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 11, 2023 Category: Pharmaceuticals Source Type: news

The 5-Steps to Relieve Tinnitus
My patient T.K. was a wreck. He looked like he hadn’t slept in a week. I asked him what was going on. “It’s nothing you can fix, doc,” he said. “I’ve been to three specialists, and they all told me the same thing… “I’ve got tinnitus, and I just have to live with it.” Luckily, I was able to help him. Tinnitus is an aggravating, nerve-racking, and unseen condition. The constant ringing in your ears robs you of sleep, makes you miserable as it drowns out your hearing, and, over time, makes you more prone to illness. Tinnitus also shatters your focus and concentration. Sadly, up to 25% of the U.S. populatio...
Source: Al Sears, MD Natural Remedies - August 9, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Source Type: news

New Consensus on Managing Acetaminophen Poisoning New Consensus on Managing Acetaminophen Poisoning
Experts trained in multiple relevant clinical specialties have developed a consensus statement on emergency management of acetaminophen poisoning.Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - August 8, 2023 Category: Psychiatry Tags: Psychiatry News Source Type: news

Whatever Happened To Cabinet Health After Shark Tank?
Learn More Whatever Happened To Cabinet Health After Shark Tank? Sustainability is becoming increasingly relevant discussion point within our everyday lives, from which car we drive to where we get our clothes. Entrepreneurs and close friends Russell Gong and Achal Patel saw their own way to…#russellgong #achalpatel #cabinethealth #patel #acetaminophen #sharktank #markcuban #fda #barbaracorcoran #lorigreiner (Source: Reuters: Health)
Source: Reuters: Health - July 30, 2023 Category: Consumer Health News Source Type: news

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease - Chidiac AS, Buckley NA, Noghrehchi F, Cairns R.
INTRODUCTION: Paracetamol is one of the most used medicines worldwide and is the most common important poisoning in high-income countries. In overdose, paracetamol causes dose-dependent hepatotoxicity. Acetylcysteine is an effective antidote, however despi... (Source: SafetyLit)
Source: SafetyLit - July 19, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Acute esophageal necrosis following acetaminophen overdose: an unreported cause of black esophagus - Dziadkoweic KN, Reddy R, Marcus AJ.
Description Acute esophageal necrosis (AEN), also known as "black esophagus" or Gurvits syndrome, is an uncommon finding with an unclear etiology and pathogenesis. This condition often presents as an upper gastrointestinal bleed in older men with multiple ... (Source: SafetyLit)
Source: SafetyLit - July 12, 2023 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

Tea Woman Charged with Tampering with Consumer Products and Obtaining Controlled Substances by Fraud
FDA OCI, Brittany Enstad, Tea, South Dakota, indict, R.N., nurse, OxyContin, hydrocodone bitartrate, oxycodone hydrochloride, oxycodone and acetaminophen, remove, blister pack, replace, different, medications, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - June 12, 2023 Category: Medical Law Authors: DOJ Source Type: news

‘Spermageddon’: Why men are at the centre of a global fertility crisis
A recent bombshell study found that sperm counts are plummeting faster than we thought. What is driving this trend, and can we reverse it? Staring at negative pregnancy tests, enduring the rollercoaster of fertility treatments and the heartbreak of miscarriages: struggling to conceive a child can…#hagailevine #shannaswan #richardsharpe #euronewsnext #bradleyanawalt #countdown #joerogans #danish #pfas #acetaminophen (Source: Reuters: Health)
Source: Reuters: Health - May 26, 2023 Category: Consumer Health News Source Type: news