Prophylactic cyclo-oxygenase inhibitor drugs for the prevention of morbidity and mortality in extremely preterm infants: a clinical practice guideline incorporating family values and preferences
Importance
Prophylactic cyclo-oxygenase inhibitors (COX-Is) such as indomethacin, ibuprofen and acetaminophen may prevent morbidity and mortality in extremely preterm infants (born ≤28 weeks’ gestation). However, there is controversy around which COX-I, if any, is the most effective and safest, which has resulted in considerable variability in clinical practice.
Our objective was to develop rigorous and transparent clinical practice guideline recommendations for the prophylactic use of COX-I drugs for the prevention of mortality and morbidity in extremely preterm infants.
The Grading of Recommendatio...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Mitra, S., Whitehead, L., Smith, K., Maclean, B., Nixon, R., Veysey, A., Campbell-Yeo, M., Kuhle, S., Gale, C., Soll, R., Dorling, J., Johnston, B. C. Tags: Reviews Source Type: research
Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
CONCLUSION: The available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.STUDY REGISTRATION: PROSPERO (CRD42021286495); first submitted 19 November 2021.PMID:38622469 | DOI:10.1007/s12630-024-02760-y (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Danilo Osorio Diana Maldonado Koen Rijs Caroline van der Marel Markus Klimek Jose A Calvache Source Type: research
Rapid identification of potential nonsteroidal anti-inflammatory drug overdose-induced liver toxicity and prediction of follow-up exposure: Integrating bioanalytical and population pharmacokinetic assay
Biomed Chromatogr. 2024 Apr 15:e5877. doi: 10.1002/bmc.5877. Online ahead of print.ABSTRACTNonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs that can cause liver toxicity. The aim of this study was to integrate bioanalytical and population pharmacokinetic (PopPK) assay to rapidly screen and quantify the concentrations of NSAIDs in plasma and monitor clinical safety. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous quantification of acetaminophen (APAP), flurbiprofen (FLB), aspirin (ASP), and ibuprofen (IBP), four commonly used NSAIDs....
Source: Biomedical Chromatography : BMC - April 15, 2024 Category: Biomedical Science Authors: Sufeng Zhou Tangping Zhao Jie Wang Luming Wang Zimo Zhang Jinying Zhu Yuqing Zhao Ying Zhu Hao Sun Feng Shao Source Type: research
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation
This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism.PMID:38621493 | DOI:10.1016/j.chemosphere.2024.142006 (Source: Chemosphere)
Source: Chemosphere - April 15, 2024 Category: Chemistry Authors: Rodrigo B Carneiro Gisele M Gomes Franciele P Camargo Marcelo Zaiat Álvaro J Santos-Neto Source Type: research
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation
This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism.PMID:38621493 | DOI:10.1016/j.chemosphere.2024.142006 (Source: Chemosphere)
Source: Chemosphere - April 15, 2024 Category: Chemistry Authors: Rodrigo B Carneiro Gisele M Gomes Franciele P Camargo Marcelo Zaiat Álvaro J Santos-Neto Source Type: research
Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
CONCLUSION: The available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.STUDY REGISTRATION: PROSPERO (CRD42021286495); first submitted 19 November 2021.PMID:38622469 | DOI:10.1007/s12630-024-02760-y (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Danilo Osorio Diana Maldonado Koen Rijs Caroline van der Marel Markus Klimek Jose A Calvache Source Type: research
Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
ConclusionThe available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.Study registrationPROSPERO (CRD42021286495); first submitted 19 November 2021. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - April 15, 2024 Category: Anesthesiology Source Type: research
GSE255835 The p21+ Perinecrotic Hepatocytes Produce the Chemokine Cxcl14 After a Severe Acetaminophen Overdose Promoting Hepatocyte Injury and Delaying Regeneration
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
The p21 < sup > + < /sup > Perinecrotic Hepatocytes Produce the Chemokine CXCL14 After a Severe Acetaminophen Overdose Promoting Hepatocyte Injury and Delaying Regeneration
Toxicology. 2024 Apr 11:153804. doi: 10.1016/j.tox.2024.153804. Online ahead of print.ABSTRACTFifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality. We hypothesized that a discrete popu...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: David S Umbaugh Nga T Nguyen Sawyer H Smith Anup Ramachandran Hartmut Jaeschke Source Type: research
The p21 < sup > + < /sup > perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration
Toxicology. 2024 Apr 12;504:153804. doi: 10.1016/j.tox.2024.153804. Online ahead of print.ABSTRACTFifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality. We hypothesized that a discrete ...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: David S Umbaugh Nga T Nguyen Sawyer H Smith Anup Ramachandran Hartmut Jaeschke Source Type: research
Novel Topical Treatments for Itch
AbstractThe experience of itch often poses a burden on patient quality of life and has the capacity to inflict significant suffering. Topical therapies are a mainstay of treatment for many cutaneous and systemic diseases and afford patients the opportunity to manage their conditions without many of the systemic side effects of non-topical therapies. We review a multitude of new topical medications targeting the skin, immune system, and neural receptors. The list includes Janus kinase inhibitors, tyrosine kinase inhibitors, phosphodiesterase inhibitors, transient receptor vanilloid inhibitors, topical cannabinoids, and topi...
Source: Dermatology and Therapy - April 13, 2024 Category: Dermatology Source Type: research
Environmental risk assessment of selected pharmaceuticals in hospital wastewater in nothern vietnam
This study investigated the occurrence of selected pharmaceuticals in influent and effluent of wastewater treatment plants of 12 hospitals in Hanoi and 3 northern cities of Vietnam during dry and rainy seasons. In addition, environmental risk of pharmaceuticals in both hospital influents and effluents were evaluated based on risk quotients (RQs). Nine selected pharmaceutical compounds including sulfamethoxazole (SMX), naproxen (NPX), diclofenac (DCF), ibuprofen (IBU), acetaminophen (ACT), carbamazepine (CBM), iopromide (IOP), atenolol (ATN), and caffeine (CAF) were frequently detected in most influent and effluent wastewat...
Source: Chemosphere - April 12, 2024 Category: Chemistry Authors: Anh T P Hoang Manh Cuong Do Kyoung-Woong Kim Source Type: research
Effect of an intravenous acetaminophen/ibuprofen fixed-dose combination on postoperative opioid consumption and pain after video-assisted thoracic surgery: a double-blind randomized controlled trial
ConclusionPerioperative administration of acetaminophen/ibuprofen significantly decreased analgesic needs in patients undergoing VATS, providing an effective postoperative pain management strategy, and potentially minimizing the need for stronger analgesics. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 12, 2024 Category: Surgery Source Type: research
Is postnatal acetaminophen therapy problematic for preterm infants?
Pediatr Res. 2024 Apr 10. doi: 10.1038/s41390-024-03204-5. Online ahead of print.NO ABSTRACTPMID:38600300 | DOI:10.1038/s41390-024-03204-5 (Source: Pediatric Research)
Source: Pediatric Research - April 10, 2024 Category: Pediatrics Authors: Richard J Martin Anna Maria Hibbs Source Type: research
