Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult.
Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice
https://www.fightaging.org/archives/2023/03/increased-mir-181a-5p-expression-improves-neural-stem-cell-activity-learning-and-memory-in-old-mice/
Neurogenesis occurs throughout life to support the changes in neural structure inherent in learning and memory. It also provides some resilience to brain injury, when it comes to maintaining and restoring function. In the process of neurogenesis, new daughter neurons are generated by neural stem cells, and then mature and integrate into existing neural networks in brain tissue. This is all largely studied in mice, due to the difficulties inherent in obtaining access to living human brains, but despite some debate it is reasonable to assume that learning and memory in our species are similarly supported by ongoing neurogenesis throughout life.
Unfortunately, stem cell populations decline in activity with advancing age. This is in part the r...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
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