Fight Aging! Newsletter, July 8th 2019

In this study, we identify a link between members of the genus Veillonella and exercise performance. We observed an increase in Veillonella relative abundance in marathon runners postmarathon and isolated a strain of Veillonella atypica from stool samples. Inoculation of this strain into mice significantly increased exhaustive treadmill run time. Veillonella utilize lactate as their sole carbon source, which prompted us to perform a shotgun metagenomic analysis in a cohort of elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative abundance postexercise. Using labeled lactate in mice, we demonstrate that serum lactate crosses the epithelial barrier into the lumen of the gut. We also show that intrarectal instillation of propionate is sufficient to reproduce the increased treadmill run time performance observed with V. atypica gavage. Taken together, these studies reveal that V. atypica improves run time via its metabolic conversion of exercise-induced lactate into propionate, thereby identifying a natural, microbiome-encoded enzymatic process that enhances athletic performance. First Cryopreservation Following Use of Assisted Death Legislation in California https://www.fightaging.org/archives/2019/07/first-cryopreservation-following-use-of-assisted-death-legislation-in-california/ Simple human dignity and self-ownership demands the right to end one's own life on one's own terms, and to be ab...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Is erector spinae plane block an effective strategy to improve postsurgical analgesia?BMC Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
What can serum calprotectin levels tell us about disease activity and severity in inflammatory rheumatic diseases?Arthritis Research &Therapy
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Authors: Mjaess G, Karam A, Aoun F, Albisinni S, Roumeguère T Abstract COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help und...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
HIGH blood pressure risk could be lowered by making some diet or exercise changes. You could lower your chances of developing deadly hypertension symptoms and signs by doing certain exercises at home. But this is the gym workout routine you should avoid, or you risk high blood pressure symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
TYPE 2 diabetes affects roughly more than one in 16 people in the UK with around 3.9 million living with the dangerous condition. Finding healthy ways to help lower your blood sugar is pertinent when it comes to living with the condition and according to experts, drinking this beverage will help lower your blood sugar. What is it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
HOW TO live longer: A long and healthy life is universally appealing but it requires tenacious commitment. There is no panacea but specific dietary decisions have been shown to support you in this endeavour, including drinking an herbal tea.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
AbstractBackgroundThe aim of the study was to determine factors predicting lymph node metastasis in patients with T1 or T2 colon cancer.MethodsA total of 906 patients with T1 or T2 colon cancer who underwent colon resection with regional lymphadenectomy in a tertiary hospital, from January 2008 to December 2013, were analyzed. The prognostic factors for LN metastasis and the risk factors for survival were analyzed.ResultsThere were 728 patients (80.4%) without lymph node metastasis (LN-negative group) and 178 patients (19.6%) with lymph node metastasis (LN-positive group). Tumor invasion depth (P
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionsThe addition of ICT before NCRT seemingly shows no survival benefit on patients with LARC, and might increase the toxicity.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
SummaryChemotherapy has always been the first therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) with untreatable oncogenic mutations. However, chemotherapy has demonstrated limited success and is associated with severe side effects. This research aimed to investigate the antitumor efficacy and cytotoxic safety of the conjugate ZHER2:V2-pemetrexed, a novel targeted chemotherapeutic drug. In this context, human epidermal growth factor receptor 2 (HER2)  + A549 lung xenografts were treated using ZHER2:V2-pemetrexed, pemetrexed or physiological saline. Therapeutic efficacy was monit...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
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