Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid

Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitive marker of CNS involvement compared with serum analyses alone.BackgroundOrganic psychiatric disorders might be of immunological, infectious, epileptic, neurodegenerative, traumatic, metabolic, or vascular origins (1, 2). In recent years, limbic or nonlimbic autoimmune encephalitis received increased interest because each can mimic primary psychiatric and neuropsychiatric disorders (2–4). Most of these disorders are associated with autoantibodies (abs) directed against antigens on the cell surface or in the intracellular compartment (5). Hashimoto thyroiditis and rheumatic disorders, such as systemic lupus erythematosus (SLE), can also be associated with psychiatric involvement that allows for successful immunomodulatory treatment approaches (6–9).SLE is a prototypic systemic autoimmune disease that can affect the central nervous system (CNS) as ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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ConclusionPositron emission computed tomography is useful for the diagnosis of head and neck squamous cell carcinoma, improving the patient's staging especially when detecting cervical and distant metastases. Therefore, we consider that the use of positron emission computed tomography for the staging of patients with head and neck squamous cell carcinoma is a diagnostic test to be considered.ResumoIntroduçãoO carcinoma espinocelular de cabeça e pescoço é o sétimo tumor maligno mais comum. Os avanços no tratamento melhoraram as taxas de sobrevida global nos últimos ano...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 20 July 2019Source: Pharmacological ResearchAuthor(s): Jiasi Wu, Yu Luo, Qing Jiang, Sheng Li, Wenge Huang, Li Xiang, Deming Liu, Yingfan Hu, Ping Wang, Xiaoxia Lu, Guolin Zhang, Fei Wang, Xianli MengAbstractInflammasome mediates the activation of caspase-1, which promotes the secretion of proinflammatory cytokines. In this work, we aimed to investigate whether natural compounds from a Traditional Chinese Medicine prescription called San-Huang-Xie-Xin-Tang exert its clinical efficacy by inhibiting inflammasome activation and the underlying mechanism. The inhibitory effects of compounds on...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionThese results clearly demonstrated the lignans from Schisandra sphenanthera exert hepatoprotective effects against LCA-induced cholestasis by activation of PXR. These lignans may provide an effective approach for the prevention and treatment of cholestatic liver injury.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 July 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): B. Bancalari, B. Llombart, C. Requena, J.B. Vendrell
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
DiscussionWe estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Justin GreiweAbstractAs technology improves and telehealth companies continue to innovate, the ways in which physicians can provide care for their patients is constantly expanding. Providing quality healthcare is no longer constrained by local commutes and a brick and mortar footprint, but instead can be provided at a local, regional and national level in ways that were not feasible in the past. The possibilities are endless as we enter a brave new world where medicine and technology meet. But what e...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionOver 60% of Medicare patients with asthma continued and were adherent to omalizumab over 12-month follow-up. Patient age, LIS status, and the numbers of evaluation and management physician visits were among factors associated with treatment adherence and discontinuation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusions and implicationsThe predictive patterns of phonological awareness on reading fluency are complex and depend on many factors, while vocabulary knowledge is an important and consistent predictor for both deaf and hearing children.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: Available online 20 July 2019Source: Materials Today: ProceedingsAuthor(s): S. Sathish, V. Anandakrishnan, Manoj GuptaAbstractMagnesium based metal-metal composite was synthesized through the disintegrated melt deposition technique with the inclusion of aluminium and titanium powders. To examine the metallurgical features of the metal-metal composite the samples of the produced composite was subjected to x-ray diffraction analysis and scanning electron microscopy analysis. To study the tribology of the metal-metal composite, pins of composites were subjected to dry sliding wear test as per standards and t...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Joanna Michalska, Maciej Sowa, Magdalena Piotrowska, Magdalena Widziołek, Grzegorz Tylko, Grzegorz Dercz, Robert P. Socha, Anna M. Osyczka, W. SimkaAbstractThe present work concerns the surface modification of The Ti-13Nb-13Zr alloy by electropolishing and plasma electrolytic oxidation (PEO) process in Ca-containing electrolytes: calcium formate and calcium lactate solutions (0.1–1.0 mol dm−3) under voltages of 200 and 400 V. As a result of the PEO process, a porous oxide layer containing incorporated calciu...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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