Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid

Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitive marker of CNS involvement compared with serum analyses alone.BackgroundOrganic psychiatric disorders might be of immunological, infectious, epileptic, neurodegenerative, traumatic, metabolic, or vascular origins (1, 2). In recent years, limbic or nonlimbic autoimmune encephalitis received increased interest because each can mimic primary psychiatric and neuropsychiatric disorders (2–4). Most of these disorders are associated with autoantibodies (abs) directed against antigens on the cell surface or in the intracellular compartment (5). Hashimoto thyroiditis and rheumatic disorders, such as systemic lupus erythematosus (SLE), can also be associated with psychiatric involvement that allows for successful immunomodulatory treatment approaches (6–9).SLE is a prototypic systemic autoimmune disease that can affect the central nervous system (CNS) as ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Publication date: Available online 26 May 2020Source: Inorganic Chemistry CommunicationsAuthor(s): Li Xiao, Jin-Meng Yang, Gao-Yuan Huang, Yue Zhao, Hai-Bin Zhu
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
New J. Chem., 2020, Advance Article DOI: 10.1039/D0NJ00320D, PaperHengbo Zhang, Fuquan Niu, Shaoyu Li, Yanhong Yin, Hongyu Dong, Hongyun Yue, Zhaoxia Cao, Shuting Yang Co/Co9S8 anchored to N,S co-doped carbon nanosheets resulting T-CCSNC electrocatalysts show excellent ORR and OER catalytic activity and stability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
J. Mater. Chem. A, 2020, Accepted Manuscript DOI: 10.1039/D0TA04240D, PaperShao-Ling Chang, Fong-Yi Cao, Kuo-Hsiu Huang, Wei-Liang Lee, Meng-Hsun Lee, Chain Shu Hsu, Yen-Ju Cheng NC-FIC nonfullerene acceptor, using a didodecylnaphthodithiophene (NDT) embedded octacyclic ladder-type donor NC, had been described previously. In this work, a new cross-shaped TC-FIC nonfullerene acceptor is designed by substitution of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
J. Mater. Chem. A, 2020, Accepted Manuscript DOI: 10.1039/D0TA01636E, Paperfangfang cai, hongjian peng, Honggang Chen, Jun Yuan, Jiefeng Hai, Tsz-Ki Lau, Ju Wang, Yunbin Hu, Wei Liu, Xinhui Lu, Yingping Zou In comparison with symmetric small molecule acceptors (SMAs), their asymmetric counterparts have received much less attention. Organic solar cells (OSCs) based on asymmetric non-fullerene SMAs previously reported show relatively low... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Green Chem., 2020, Accepted Manuscript DOI: 10.1039/D0GC01194K, CommunicationAjmal Khan, Junjie Zhang, Shahid Khan The development of green, economical and sustainable chemical processes is one of the primary challenges in organic chemistry. Herein, we report a recoverable heterogenous palladium catalysis for the stereoselective synthesis... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - Category: Chemistry Authors: Source Type: research
Authors: Zhang XL, Liu Z Abstract The aim of this study is to explore the regulatory effect of micro ribonucleic acid (miR)-19a on diabetic retinopathy (DR) through mediating the phosphatase and tensin homolog deleted on chromosome ten (PTEN)/protein kinase B (Akt) signaling pathway. Thirty male Sprague-Dawley rats were first divided into Healthy group, DR group and miR-19a inhibitor group. The DR model was induced by intraperitoneal injection of streptozotocin (STZ) (60 mg/kg). The retinal tissues were dissected and RGCs were isolated. The expression level of miR-19a therein was determined using quantitative polym...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Exclusive:Australian researchers query origin of data used for Lancet study, but stress there is no evidence drug is a safe or effective treatment•Sign up for Guardian Australia ’s daily coronavirus email•Download the free Guardian app to get the most important news notificationsQuestions have been raised by Australian infectious disease researchers about a study published in the Lancet which prompted the World Health Organization to halt global trials of the drug hydroxychloroquine to treat Covid-19.Thestudy published on Friday found Covid-19 patients who received the malaria drug were dying at higher rate...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Coronavirus outbreak Health Australia news World Health Organization Infectious diseases New South Wales Victoria Source Type: news
CONCLUSIONS: In patients at high risk of restenosis, non-inferiority of BVS compared with EES in terms of TLF was met at 1 year. BVS carried a higher risk of device thrombosis and TVMI than EES. PMID: 32451321 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
CONCLUSIONS: Both the WATCHMAN and the ACP/Amulet occluder provide excellent procedural results with comparable implantation success and no differences with respect to procedural safety and long-term effectiveness. PMID: 32451320 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Acute pulmonary embolism (PE) is associated with high in-hospital morbidity and mortality, both via cardiorespiratory decompensation and the bleeding complications of treatment. Thrombolytic therapy can be life-saving in those with high-risk PE, but requires careful patient selection. Patients with PE and systemic arterial hypotension ( “massive PE”) should receive thrombolytic therapy unless severe contraindications are present. Patients with PE and right ventricular dysfunction/injury, but without hypotension (“submassive PE”), should be considered for thrombolysis on a case-by-case basis, conside...
Source: Critical Care Clinics - Category: Intensive Care Authors: Source Type: research
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