First test to detect recently discovered autoimmune disease associated with testicular cancer
Mayo Clinic Laboratories has launched a first-of-its-kind test to detect an autoimmune disease called testicular cancer-associated paraneoplastic encephalitis. The test, available nationally and internationally, detects the Kelch-like protein 11 antibody, or KLHL11, and is a result of the breakthrough study from 2019 that discovered the disease. This test has already provided patients, such as Steven Wopperer of [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - June 16, 2021 Category: Hospital Management Source Type: news
Arthritis As an Initial Presentation of Malignancy Arthritis As an Initial Presentation of Malignancy
These two patients were initially diagnosed and treated for rheumatic diseases, but were later found to have paraneoplastic arthritis related to occult malignancy.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 18, 2021 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
Phencyclidine: a rare cause of saccadic intrusions - Shameer Nijam MN, Thambirajah N, Vithanawasam D, Vithanage K, Liyanage DS, Gooneratne IK, Senanayake S.
Saccadic intrusions such as opsoclonus and ocular flutter are often due to a paraneoplastic or a parainfectious condition. Toxins/drugs may rarely cause them. Herein, we report a rare case of ocular flutter/opsoclonus due to phencyclidine (PCP) toxicity. O... (Source: SafetyLit)
Source: SafetyLit - November 25, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Scientists discover autoimmune disease associated with testicular cancer
(University of California - San Francisco) Using advanced technology, scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and University of California, San Francisco (UCSF), have discovered an autoimmune disease that appears to affect men with testicular cancer.Called 'testicular cancer-associated paraneoplastic encephalitis,' the disease causes severe neurological symptoms in men. They progressively lose control of their limbs, eye movements, and speech. The disease begins with a testicular tumor, which may cause the immune system to attack the brain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 3, 2019 Category: International Medicine & Public Health Source Type: news
Scientists discover autoimmune disease associated with testicular cancer
Technology that uncovered antibody has potential to identify other autoimmune diseases ROCHESTER, Minn. -- Using advanced technology, scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and University of California, San Francisco (UCSF), have discovered an autoimmune disease that appears to affect men with testicular cancer. Called "testicular cancer-associated paraneoplastic encephalitis," the disease causes severe neurological [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 2, 2019 Category: Research Source Type: news
Autoimmune Dementia Autoimmune Dementia
This review summarizes the available evidence concerning the diagnosis and care of autoimmune and paraneoplastic encephalitis patients with associated cognitive impairment.Seminars in Neurology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 12, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
FDG PET/CT Can Find Malignancy Source in Paraneoplastic Syndrome FDG PET/CT Can Find Malignancy Source in Paraneoplastic Syndrome
A new meta-analysis shows that 18F-FDG PET, and 18F-FDG PET/CT in particular, are useful diagnostic tools in paraneoplastic syndrome.Medscape Radiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 25, 2017 Category: Consumer Health News Tags: Hematology-Oncology Viewpoint Source Type: news
Paraneoplastic IGF-2 From a Malignant Renal Solitary TumorParaneoplastic IGF-2 From a Malignant Renal Solitary Tumor
What caused this non-diabetic patient to have hypoglycemia? BMC Endocrine Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 5, 2014 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Paraneoplastic hypoglcemia induced by MSFT
Hypoglycemia is a common medical emergency and is the most frequent complication induced by anti-diabetic treatment. However, it can be observed in other conditions unrelated to diabetes such as insulinoma, autoimmune disorders, and neoplasia.
Mohammedi et al. report the case of a rare cause of severe and recurrent hypoglycemia in a 77-year-old woman with a malignant solitary fibrous tumor (MSFT). A diagnosis of a non-islet cell tumor-induced hypoglycemia (NICTH) was established by the presence of incompletely processed precursors of IGF2 (big IGF2) in plasma electrophoresis. Therapy with corticostero...
Source: Society for Endocrinology - June 26, 2014 Category: Endocrinology Source Type: news
What Is Paraneoplastic Syndrome?
Definition of paraneoplastic syndrome, a variety of symptoms due to the presence of a tumor in the body. (Source: About.com Lung Cancer)
Source: About.com Lung Cancer - May 13, 2014 Category: Cancer & Oncology Tags: health Source Type: news
Robert Darnell elected to National Academy of Sciences
Darnell, who focuses on understanding a group of rare brain diseases, the paraneoplastic neurologic disorders (PNDs), and how they arise in conjunction with immune responses to cancer, is one of 84 newly elected members announced today by the Academy.
More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 29, 2014 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors New York Genome Center robert darnell U.S. National Academy of Sciences Source Type: news
Must-read: Anti-NMDA Receptor Encephalitis
4.5 out of 5 stars
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis: an etiology worth considering in the differential of delirium. Punja M et al. Clin Toxicol 2013 Aug 20 [Epub ahead of print]
Abstract
This important paper is a must-read, especially for toxicologists who have not heard of this under-appreciated neurological disorder. (I was not aware of it until several days ago, when I found out that a friend of a relative had received the diagnosis.) Anti-NMDA encephalitis was first described in 2005. Advanced cases often develop altered mental status, autonomic instability, increased muscle tone, and move...
Source: The Poison Review - August 28, 2013 Category: Toxicology Authors: Leon Tags: Best of TPR Medical anti-n-methyl-d-aspartate receptor anti-NMDA receptor encephalitis autoimmune neurologic Source Type: news
Paraneoplastic Necrotizing Myopathy in Lung CancerParaneoplastic Necrotizing Myopathy in Lung Cancer
Paraneoplastic necrotizing myopathy is a recently defined clinical entity, characterized by massive necrosis of muscle fibers. What was the underlying cause in this patient? Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Treatment for paraneoplastic neuropathies
Source: Cochrane
Area: Evidence > Disease Focused Reviews
Background
It is not unusual to observe peripheral nervous system involvement in people with tumours outside the nervous system. Any part of the peripheral nervous system can be involved, from sensory and motor neurons to nerve roots and plexuses, from distal trunks to neuromuscular junctions. Pathogenesis also varies from direct infiltration by cancer cells, to treatment toxicity, to metabolic derangement, cachexia, infections and paraneoplastic syndromes.
Paraneoplastic neurological syndromes are symptoms or signs resulti...
Source: NeLM - Disease Focused Reviews - January 3, 2013 Category: Internal Medicine Source Type: news
