'Hypercoagulation,' Antiphospholipid Antibodies Seen in COVID-19
Marked coagulopathy and presence of antiphospholipid antibodies and cerebral infarcts in patients with COVID-19 suggest the infection represents a 'hypercoagulable' state, experts write. (Source: WebMD Health)
Source: WebMD Health - April 15, 2020 Category: Consumer Health News Source Type: news

' Hypercoagulation,' Antiphospholipid Antibodies Seen in COVID-19'Hypercoagulation,' Antiphospholipid Antibodies Seen in COVID-19
Marked coagulopathy and presence of antiphospholipid antibodies and cerebral infarcts in patients with COVID-19 suggest the infection represents a'hypercoagulable'state, experts write.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - April 14, 2020 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Landmark Phase 3 VOYAGER PAD Study of XARELTO ® (rivaroxaban) Plus Aspirin Shows Significant Benefit in Patients with Symptomatic Peripheral Artery Disease (PAD) after Lower-Extremity Revascularization
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI[1] major bleeding. VOYAGER PAD is the only study to show a significant benefi...
Source: Johnson and Johnson - March 28, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Highlights Continued Commitment to Cardiovascular & Metabolic Healthcare Solutions with Late-Breaking Data at the First Fully Virtual American College of Cardiology Scientific Session
RARITAN, N.J., March 20, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that it will unveil late-breaking data from its leading cardiovascular and metabolism portfolio during the virtual American College of Cardiology’s 69th Annual Scientific Session together with the World Congress of Cardiology (ACC.20/WCC) on March 28-30, 2020. Notably, four late-breaking abstracts for XARELTO® (rivaroxaban) will be presented, including data from the Phase 3 VOYAGER PAD study in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization.Click to...
Source: Johnson and Johnson - March 20, 2020 Category: Pharmaceuticals Source Type: news

Rivaroxaban Misfires in Antiphospholipid Syndrome Rivaroxaban Misfires in Antiphospholipid Syndrome
Rivaroxaban not only failed to show noninferiority to warfarin, but trended toward higher thrombosis risk in patients with APS.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 17, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Study Compares Anticoagulants for Antiphospholipid Syndrome
TUESDAY, Oct. 15, 2019 -- In thrombotic antiphospholipid antibody syndrome (APS), rivaroxaban is not noninferior to dose-adjusted vitamin K antagonists (VKAs), according to a study published online Oct. 15 in the Annals of Internal Medicine. Josep... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 15, 2019 Category: Pharmaceuticals Source Type: news

DAPT for Preventing Thrombosis in Antiphospholipid Syndrome DAPT for Preventing Thrombosis in Antiphospholipid Syndrome
Can dual antiplatelet therapy effectively prevent thrombosis recurrence in patients with antiphospholipid syndrome? How does it compare to warfarin?Rheumatology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 4, 2019 Category: Allergy & Immunology Tags: Rheumatology Journal Article Source Type: news

How common gut bacteria trigger a lethal autoimmune disease
Antiphospholipid syndrome, an immune system disorder that raises the risk of blood clots, may be triggered by the common gut bactrium Roseburia intestinalis. (Source: Yale Science and Health News)
Source: Yale Science and Health News - June 18, 2019 Category: Universities & Medical Training Source Type: news

A probable case of catastrophic antiphospholipid syndrome: Should high-dose steroids be given in the setting of polymicrobial sepsis?
In this clinical vignette, we present a case of a 59-year-old woman with catastrophic antiphospholipid syndrome likely triggered by polymicrobial sepsis. The diagnostic criteria and clinical manifestations of catastrophic antiphospholipid syndrome are reviewed. We also compare diagnostic criteria and clinical manifestations with other clinical entities in the differential diagnosis, including thrombotic thrombocytopenic purpura-hemolytic-uremic syndrome, disseminated intravascular coagulation, sepsis, and inflammatory bowel disease. Catastrophic antiphospholipid syndrome is a rare, but lethal condition, and treatment recom...
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news

Impeding white blood cells in antiphospholipid syndrome reduced blood clots
(Michigan Medicine - University of Michigan) A new study examined APS at the cellular level and found that two drugs reduced development of blood clots in mice affected with the condition. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 25, 2019 Category: International Medicine & Public Health Source Type: news

Antiphospholipid Syndrome: Insights Into a Rare Autoimmune Disease Antiphospholipid Syndrome: Insights Into a Rare Autoimmune Disease
A conversation with Dr Doruk Erkan about the proper diagnosis and management of this life-threatening clotting disease.Hospital for Special Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 29, 2019 Category: Consumer Health News Tags: Rheumatology Expert Interview Source Type: news

Presence of Antiphospholipid Antibodies Tied to First-Time MI
FRIDAY, Nov. 30, 2018 -- There is a strong and independent association between the presence of antiphospholipid antibodies (aPLs) and first-time myocardial infarction (MI), according to a research letter published recently in the Annals of Internal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 30, 2018 Category: Pharmaceuticals Source Type: news

Pregnancy and APS: Results Look Encouraging (CME/CE)
(MedPage Today) -- Intrauterine fetal death was the first sign in most women with antiphospholipid syndrome (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 7, 2018 Category: Rheumatology Source Type: news

Antiphospholipid Antibody Linked to First MI Antiphospholipid Antibody Linked to First MI
The case-control PAROKRANK study identified a strong association between an anticardiolipin antibody and MI, but also raises a host of new questions about the relationship.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 23, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

Antibodies Common in Autoimmune Disorders Could Be MI Risk Factor
(MedPage Today) -- Antiphospholipid antibodies out-predicted conventional factors (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 23, 2018 Category: Rheumatology Source Type: news

Antibodies linked to heart attacks
(Karolinska Institutet) Levels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoimmune co-morbidity, a study from Karolinska Institutet in Sweden published in The Annals of Internal Medicine reports. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 22, 2018 Category: International Medicine & Public Health Source Type: news

Across the Table on Antiphospholipid Syndrome
(MedPage Today) -- Jack Cush, MD, and Doruk Erkan, MD, MPH, discuss this sometimes frustrating condition (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - December 31, 2017 Category: American Health Source Type: news

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis
Blood coagulation functions as part of the innate immune system by preventing bacterial invasion, and it is critical to stopping blood loss (hemostasis). Coagulation involves the external membrane surface of activated platelets and leukocytes. Using lipidomic, genetic, biochemical, and mathematical modeling approaches, we found that enzymatically oxidized phospholipids (eoxPLs) generated by the activity of leukocyte or platelet lipoxygenases (LOXs) were required for normal hemostasis and promoted coagulation factor activities in a Ca2+- and phosphatidylserine (PS)–dependent manner. In wild-type mice, hydroxyeicosatet...
Source: Signal Transduction Knowledge Environment - November 28, 2017 Category: Science Authors: Lauder, S. N., Allen-Redpath, K., Slatter, D. A., Aldrovandi, M., OConnor, A., Farewell, D., Percy, C. L., Molhoek, J. E., Rannikko, S., Tyrrell, V. J., Ferla, S., Milne, G. L., Poole, A. W., Thomas, C. P., Obaji, S., Taylor, P. R., Jones, S. A., de Groot Tags: STKE Research Articles Source Type: news

Heartbroken woman, 23, who lost five babies in six years
Shannon Reed, 23, from Prudhoe, near Newcastle, has been diagnosed with 'sticky blood syndrome', or antiphospholipid syndrome - after years of mystery surrounding her miscarriages. (Source: the Mail online | Health)
Source: the Mail online | Health - November 8, 2017 Category: Consumer Health News Source Type: news

Antiphospholipid syndrome: diagnosis and management
Dr Anisur Rahman and Dr Salma Ahmed discuss the diagnosis and management of antiphospholipid syndrome (APS). (Source: GP Online Education)
Source: GP Online Education - September 13, 2017 Category: Primary Care Tags: Autoimmune disorders Source Type: news

Heparin, ASA Aids Live Birth With Antiphospholipid Antibody Heparin, ASA Aids Live Birth With Antiphospholipid Antibody
Unfractionated heparin added to aspirin is superior to aspirin alone in promoting live births among women with antiphospholipid syndrome and recurrent pregnancy loss, a meta-analysis shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 20, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Prevalence of Antiphospholipid Syndrome Up for Roma SLE
Roma systemic lupus erythematosus patients also have significantly higher prevalence of abortions (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 14, 2017 Category: Cancer & Oncology Tags: Gynecology, Oncology, Pathology, Rheumatology, Journal, Source Type: news

Antiphospholipid Syndrome: Role of Vascular Endothelial Cells Antiphospholipid Syndrome: Role of Vascular Endothelial Cells
This review explores the role of vascular endothelial cell dysfunction in antiphospholipid syndrome, an autoimmune prothrombotic condition. Might this pathway provide a viable target for therapy?Journal of the American College of Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 5, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Gut bacteria may be a trigger for antiphospholipid syndrome
The gut microbiomes of patients with antiphospholipid syndrome show higher levels of phospholipid-producing bacteria, and this findings point to microbes being a trigger for this life-threatening disease, according to new research. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 13, 2016 Category: Science Source Type: news

Gut bacteria may be a trigger for antiphospholipid syndrome
(American College of Rheumatology) The gut microbiomes of patients with antiphospholipid syndrome show higher levels of phospholipid-producing bacteria, and this findings point to microbes being a trigger for this life-threatening disease, according to new research findings presented this week at the American College of Rheumatology Annual Scientific Meeting in Washington. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 12, 2016 Category: Global & Universal Source Type: news

Rivaroxaban 'could be a safe treatment option for antiphospholipid syndrome'
The drug rivaroxaban could be an effective means of treating some patients with thromboticantiphospholipid syndrome, according to a new study. Led by University College London and funded byArthritis Research UK, the research has suggested that the drug - which works by inhibiting the formation of blood clots - could be a useful tool in the treatment of those with this serious condition, which affects approximately 15 per cent of patients withlupus and may also occur on its own. The danger of antiphospholipid syndrome Thrombotic antiphospholipid syndrome is classified as a rare condition, but is probably underdiagnosed. It ...
Source: Arthritis Research UK - August 30, 2016 Category: Rheumatology Source Type: news

Antiphospholipid Syndrome
Title: Antiphospholipid SyndromeCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 8/29/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - August 29, 2016 Category: Rheumatology Source Type: news

Pravastatin Shows Promise in Pregnant Women With Antiphospholipid Syndrome Pravastatin Shows Promise in Pregnant Women With Antiphospholipid Syndrome
Pravastatin may improve pregnancy outcomes in women with antiphospholipid syndrome (APS) refractory to standard antithrombotic therapy, a new study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 1, 2016 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

I Never Thought Stroke Would Happen to Me
by Myra Wilson, Stroke Survivor On November 3, 2014, I was in nursing school working as a student nurse at a hospital in Seattle. My first sign that something was not quite right was when I was walking through the nursing station and both of my eyes went blurry. I could still see color but I couldn't see letters. It was blurry for about 30 seconds before clearing up again. I was going to lunch and went to give a report to another nurse. The nurse noticed while I was speaking that I slurred my speech. I didn't notice my speech was slurred at all. It was at that time that I experienced a sudden sharp pain on the right s...
Source: Healthy Living - The Huffington Post - May 14, 2016 Category: Consumer Health News Source Type: news

Can Infections Trigger Autoimmunity? (CME/CE)
(MedPage Today) -- Case reports suggest a post-infectious association with antiphospholipid syndrome (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - May 10, 2016 Category: Consumer Health News Source Type: news

Newer Anticoagulants Helpful in Antiphospholipid Syndrome (CME/CE)
(MedPage Today) -- But lack of reversal agents for some complicates the picture (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - February 12, 2016 Category: Cardiology Source Type: news

Osmosis Question of the Week Feb 5, 2016Osmosis Question of the Week Feb 5, 2016
This week's question involves antiphospholipid syndrome. Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 5, 2016 Category: Consumer Health News Tags: Med Students Interactive Quiz Source Type: news

Antibody Signals Adverse Pregnancy Outcome (CME/CE)
(MedPage Today) -- Lupus anticoagulant was the only antiphospholipid antibody linked with poor birth outcome (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - January 22, 2016 Category: OBGYN Source Type: news

What Are Common Inherited Thrombophilias?
Discussion Thrombophilia is the increased risk of thromboembolic disease due to a disorder. Thrombophilia can be inherited or acquired (such as antiphospholipid syndrome). The risk of thromboembolic events is much lower in children than adults. At-risk patients should avoid: Dehydration Sitting for prolonged time periods during travel Obesity Smoking Estrogen containing oral contraceptives Common inherited thrombophilias include: Prothrombin (Factor II mutation) Second most common Genetics: 1-2% prevalence is variable depending on location and ethnic background. Cause: Abnormal point mutation of the prothrombin gene t...
Source: PediatricEducation.org - May 25, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Thrombotic Complications Still a Problem in APS (CME/CE)
(MedPage Today) -- Events and related deaths persist in patients with antiphospholipid syndrome. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 14, 2015 Category: Cardiology Source Type: news

Woman heartbroken after suffering SEVEN miscarriages finally has a baby
Samantha Bourner, 33, from Kent, suffered recurrent miscarriages due to Antiphospholipid syndrome, which increases the chance of blood clots and raises the risk of miscarriage. (Source: the Mail online | Health)
Source: the Mail online | Health - February 19, 2015 Category: Consumer Health News Source Type: news

Genes Predict Thombotic Risk
(MedPage Today) -- Screen for antiphospholipid antibodies in patients with autoimmune diseases. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 22, 2014 Category: Primary Care Source Type: news

Study Compares Anticoagulants for Antiphospholipid Syndrome
Authors find rivaroxaban not noninferior to vitamin K antagonists for secondary thromboprophylaxis (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 11, 2014 Category: Cancer & Oncology Tags: Internal Medicine, Oncology, Pharmacy, Rheumatology, Journal, Source Type: news

Drug Target Linked to Antiphospholipid SyndromeDrug Target Linked to Antiphospholipid Syndrome
The mammalian target of rapamycin complex pathway is activated in the vascular lesions that occur in patients with antiphospholipid syndrome. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 24, 2014 Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news

Antiphospholipid Antibodies and Bleeding From Renal BiopsyAntiphospholipid Antibodies and Bleeding From Renal Biopsy
A study identified the clinical and histologic risk factors for bleeding after renal biopsy in patients with lupus nephritis. Medscape Rheumatology (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - July 16, 2014 Category: Rheumatology Tags: Rheumatology Viewpoint Source Type: news

Headaches, fatigue, dizziness and memory problems: Hughes Syndrome explained
AS PART of Hughes Syndrome Awareness Month, experts explain the little-known disease, also known as Antiphospholipid Syndrome and more common than Parkinson's and multiple sclerosis, and advise what to do if you think might be at risk (Source: Daily Express - Health)
Source: Daily Express - Health - May 21, 2014 Category: Consumer Health News Source Type: news

Neonatal Antiphospholipid Syndrome
Antiphospholipid antibody syndrome (APS) during pregnancy may result in pregnancy morbidity and passive transfer of antibodies to the fetus, resulting in an increased risk of prematurity, intrauterine growth restriction, thrombocytopenia, and developmental delay. Antiphospholipid antibodies may have an impact on neurodevelopment during fetal life. Although rare, persistence of these antibodies in the neonate may lead to thromboembolism, particularly if there is a concurrent infection and/or inherited thrombophilic disorders. Affected pregnant women need to be identified early during gestation so that they can have close mo...
Source: NeoReviews recent issues - May 1, 2014 Category: Pediatrics Authors: Magalhaes, C. S., Suppo de Souza Rugolo, L. M., Trindade, C. E. P. Tags: Articles Source Type: news

TLC Immunostaining for Detection of “Antiphospholipid” Antibodies
Thin-layer chromatography (TLC) is a nonquantitative technique, which has been employed in the detection of antiphospholipid (aPL) antibodies. Antiphospholipid syndrome (APS) is the most frequently acquired thrombophilia, characterized by thrombosis and obstetric manifestations associated to an autoimmune trait, represented by the positivity of antiphospholipid (aPL) antibodies. Immunoassays for anticardiolipin (aCL) and anti-β2 glycoprotein I (aβ2GPI) antibodies and clotting tests for lupus anticoagulant (LA) represent the standard tests for the routine detection of aPL. The term “seronegative APS” h...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Measurement of Malondialdehyde, Glutathione, and Glutathione Peroxidase in SLE Patients
Oxidative stress contributes to chronic inflammation of tissues and plays a central role in immunomodulation, which may lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome. Markers of oxidative damage include malondialdehyde (MDA), antioxidant scavengers as glutathione (GSH), and glutathione peroxidase (GSH Px), which all correlate well with SLE disease activity. Amelioration of some clinical manifestations of SLE may be expected by targeting lipid peroxidation with dietary or pharmacological antioxidants. (Source: Springer protocols feed by Immunology)
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

Laboratory Tests for the Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent vascular thrombosis (VT) and/or pregnancy morbidity (PM) in the presence of persistent antiphospholipid antibodies (aPL), detected by lupus anticoagulant (LA), anticardiolipin (aCL) antibody, and/or anti‐β2 glycoprotein I (aβ2GPI) antibody assays. These aPL, considered to be diagnostic markers and pathogenic drivers of APS, are a heterogeneous group of antibodies directed against anionic phospholipids, phospholipid-binding plasma proteins, and phospholipid–protein complexes. Although APS is currently considered as a singl...
Source: Springer protocols feed by Immunology - February 7, 2014 Category: Allergy & Immunology Source Type: news

IgA Antiphospholipid Antibodies: Growing Clinical RelevanceIgA Antiphospholipid Antibodies: Growing Clinical Relevance
Testing for these autoantibodies may identify additional patients with clinical features of antiphospholipid antibody syndrome. Medscape Rheumatology (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - January 17, 2014 Category: Rheumatology Tags: Rheumatology Viewpoint Source Type: news

Antiphospholipid Syndrome
Title: Antiphospholipid SyndromeCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 1/10/2014 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - January 10, 2014 Category: Rheumatology Source Type: news

Biomarker Predicts Poor Pregnancy Outcomes in Lupus, APLBiomarker Predicts Poor Pregnancy Outcomes in Lupus, APL
Angiogenic factor dysregulation early in pregnancy can predict pre-eclampsia and poor fetal and maternal outcomes, enabling early intervention in women with lupus or antiphospholipid syndrome (APL). Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 29, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Aspirin Prophylaxis Adequate for Antiphospholipid AntibodiesAspirin Prophylaxis Adequate for Antiphospholipid Antibodies
Adding warfarin to aspirin doesn't seem to improve thromboprophylaxis in patients with antiphospholipid antibodies (aPL), according to results from the ALIWAPAS study. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 22, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Invasive Aspergillosis vs Antiphospholipid SyndromeInvasive Aspergillosis vs Antiphospholipid Syndrome
Invasive aspergillosis is a frequently missed diagnosis. This case study tells why. American Journal of Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 24, 2013 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news