Effect of Compound Kushen Injection, a Natural Compound Mixture, and Its Identified Chemical Components on Migration and Invasion of Colon, Brain, and Breast Cancer Cell Lines
Conclusion
The primary outcome of this study is the demonstration that cancer cell migration and invasion rates are significantly reduced by CKI, suggesting that therapeutic activity of CKI in human cancer patients may arise in part from downregulation of a panel of key molecular targets necessary for adhesion and motility in metastasis. The secondary outcome of this study is that multiple compounds in CKI, acting together, are responsible for this effect.
Data Availability
Data were submitted to NCBI Gene Expression Omnibus (GEO), with RNA_Seq. Accession Number GSE125743, available at https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125743.
Author Contributions
SN, TA, DA, and AY designed the study, analyzed the data and wrote the manuscript. SN and TA conducted the experiments and JC, JP, MD, YH-L, and ZQ assisted with experiments and analysis.
Funding
This work was supported by the Australian Research Council (grants DP160104641 and DP190101745); special international corporation project of traditional Chinese medicine (GZYYGJ2017035); the Chinese National Project for Standardization of Chinese Materia Medica (ZYBZH-C-JIN-43); and The University of Adelaide Zendong Australia China Centre for Molecular Chinese Medicine.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
The authors th...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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