Fight Aging! Newsletter, December 11th 2023

In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. « Back to Top Klotho as a Biomarker of the Influence of Lifestyle Choice on Health https://www.fightaging.org/archives/2023/12/klotho-as-a-biomarker-of-the-influence-of-lifestyle-choice-on-health/ Klotho is a longevity-associated protein that operates both within the cell and also as a circulating signal protein. It is longevity-associated in the sense that upregulation increases life span and downregulation reduces life span in mice, but also in the sense that measured klotho levels correlate with health and life expectancy in human epidemiological studies. Klotho may largely operate by maintaining kidney function into late life, but researchers have found that it may also help brain cells resist the harmful effects of an aged environment. In today's open access paper, the authors make the interesting point that while epigenetic clocks are ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs