Fournier Gangrene Is Safety Concern With SGLT2 Inhibitors
MONDAY, May 13, 2019 -- Fournier gangrene (FG) is a safety concern for adults with diabetes receiving treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors, according to a study published online May 7 in the Annals of Internal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 13, 2019 Category: Pharmaceuticals Source Type: news

Study warns of flesh-eating genital infection linked to diabetes drugs
A new study echoes a previous FDA warning about the link between Type 2 diabetes drugs known as SGLT2 inhibitors and the genital infection called Fournier gangrene. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - May 10, 2019 Category: Pharmaceuticals Source Type: news

SGLT2, Fournier Gangrene Link Is'Compelling'--What to Do? SGLT2, Fournier Gangrene Link Is'Compelling'--What to Do?
Fournier gangrene is an uncommon but unignorable adverse event associated with SGLT2 inhibitors. What does this mean for clinical practice?Medscape (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - May 8, 2019 Category: Internal Medicine Tags: Internal Medicine Commentary Source Type: news

Diabetes Drugs Carry Risk of Gangrene of Genitals
Popular diabetes drugs known as SGLT2 inhibitors are linked with an increased risk of developing a flesh-eating bacteria that attacks the genitals, a rare condition known as Fournier gangrene. (Source: WebMD Health)
Source: WebMD Health - May 8, 2019 Category: Consumer Health News Source Type: news

Fournier Gangrene Alarm: More Cases Linked to Diabetes Drugs Fournier Gangrene Alarm: More Cases Linked to Diabetes Drugs
Physicians prescribing SGLT2 inhibitors, a newer class of diabetes drugs, are advised to"have a high index of suspicion" about the potentially fatal complication.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 6, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

SGLT2 Inhibitors for Diabetes Linked to Rare'Flesh-Eating' Genital Infection
MONDAY, May 6, 2019 -- Say you have type 2 diabetes and you are taking a newer class of medications to treat your disease -- but one day you notice pain, redness and a foul odor in your genital area. If this happens, new research suggests you need... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 6, 2019 Category: General Medicine Source Type: news

Novel therapies slow CKD progression in patients with diabetes
(ERA-EDTA) The recently published CREDENCE study showed that SGLT2 inhibitors can slow progression of chronic kidney disease (CKD) in diabetes patients in addition to the effects seen with RAAS blockade. Canagliflozin was associated with a 34% risk reduction of the renal end point. The SONAR study had shown that the selective endothelin A receptor antagonist, atrasentan, reduced the risk of renal events in a specially selected CKD cohort with diabetes to a similar extent (35%). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 26, 2019 Category: International Medicine & Public Health Source Type: news

CREDENCE Takes SGLT2 Inhibitors'to the Next Level'CREDENCE Takes SGLT2 Inhibitors'to the Next Level '
What are the clinical implications of the CREDENCE trial? Dr Harpreet Bajaj shares his perspective on this landmark study.Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 25, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology Expert Column Source Type: news

Less HF Hospitalization on Dapagliflozin in Diabetes at Any LVEF Less HF Hospitalization on Dapagliflozin in Diabetes at Any LVEF
Survivals gains were seen in DECLARE-TIMI 58 only in those with low ejection fractions. Preliminary, but it suggests an SGLT2 inhibitor benefit in a range of people with diabetes and heart failure.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - April 4, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Diabetes and Kidney Complications Garnering Attention at ISN Diabetes and Kidney Complications Garnering Attention at ISN
First results indicating that an SGLT2 inhibitor could improve outcomes for patients with diabetes and chronic kidney disease will be presented at the upcoming nephrology world congress.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 26, 2019 Category: Consumer Health News Tags: Nephrology News Source Type: news

Low EF Heart Failure Benefits Most From SGLT2 Diabetes Drug
(MedPage Today) -- DECLARE substudy doesn't leave HFpEF entirely out, though (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 20, 2019 Category: Cardiology Source Type: news

EU Panel OKs Sotagliflozin for Some With Type 1 Diabetes EU Panel OKs Sotagliflozin for Some With Type 1 Diabetes
The decision includes a list of requirements for use of the SGLT1/ SGLT2 inhibitor in select patients to minimize DKA risk. The EU approval will be the first worldwide for sotagliflozin.International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 1, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology News Alert Source Type: news

SGLT2 Inhibitors to Prevent HF: Time to Get More Proactive? SGLT2 Inhibitors to Prevent HF: Time to Get More Proactive?
Drs Pi ñ a and Butler discuss the accumulating'consistent'data regarding SGLT2 inhibitors for prevention of heart failure in patients with diabetes.theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 4, 2019 Category: Consumer Health News Tags: Cardiology Commentary Source Type: news

Canagliflozin Not Linked to Fractures in Large Database Study Canagliflozin Not Linked to Fractures in Large Database Study
Risk associated with SGLT2 inhibitor may be limited to patients with type 2 diabetes who have additional fracture risk.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 31, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Is One SGLT2 (Or GLP-1) Just Like Another for Cardiac Benefit? Is One SGLT2 (Or GLP-1) Just Like Another for Cardiac Benefit?
A new consensus document from ACC acknowledges the'twofer'benefits of some antidiabetic drugs.Medscape Internal Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 31, 2018 Category: Consumer Health News Tags: Family Medicine/Primary Care Commentary Source Type: news

SGLT2 Inhibitors: Is This the Start of a New Era? SGLT2 Inhibitors: Is This the Start of a New Era?
Gregory Nichols discusses exciting new clinical trial results demonstrating the benefits of SGLT2 inhibitors, as presented at the AHA 2018 Scientific Sessions.Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 7, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Article Source Type: news

Certain SGLT2 Inhibitors, GLP-1 RAs for T2DM Also Cut CV Risk
THURSDAY, Nov. 29, 2018 -- Certain sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) demonstrate significant cardiovascular (CV) benefit and should be used for reducing CV risk in patients... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 29, 2018 Category: Pharmaceuticals Source Type: news

Pumps, Pipes, and Filters: SGLT2 Inhibitors for Most Type 2 Diabetes? Pumps, Pipes, and Filters: SGLT2 Inhibitors for Most Type 2 Diabetes?
The new SGLT2 inhibitors should be considered for use in most patients with type 2 diabetes because of their benefits in reducing heart failure and renal disease, according to a new meta-analysis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 23, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Empa ACC Expert Consensus Decision Pathway
American College of Cardiology recommends empagliflozin as preferred SGLT2 inhibitor for adults with type 2 diabetes and established cardiovascular disease in new Expert Consensus Decision Pathway (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 23, 2018 Category: Research Source Type: news

Higher Risk for Amputation, DKA With SGLT2 Inhibitors for T2DM
FRIDAY, Nov. 16, 2018 -- Use of sodium glucose cotransporter 2 (SGLT2) inhibitors is associated with an increased risk for lower-limb amputation and diabetic ketoacidosis compared with use of glucagon-like peptide 1 (GLP1) receptor agonists,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 16, 2018 Category: Pharmaceuticals Source Type: news

Some Diabetes Drugs, Higher Amputation Risk Linked
People on sodium-glucose cotransporter2 (SGLT2) inhibitors were twice as likely to require a lower limb amputation as people taking another type of diabetes medication, Scandinavian researchers have found. (Source: WebMD Health)
Source: WebMD Health - November 15, 2018 Category: Consumer Health News Source Type: news

Certain Diabetes Meds Tied to Higher Odds for Amputation
THURSDAY, Nov. 15, 2018 -- A specific class of diabetes medication appears to double the risk of losing a leg or foot to amputation, a new study reports. People on sodium-glucose cotransporter2 (SGLT2) inhibitors were twice as likely to require a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 15, 2018 Category: General Medicine Source Type: news

SGLT2 Inhibitors for Diabetes Linked to Increased Risk for Amputation
THURSDAY, Nov. 15, 2018 -- A specific class of diabetes medication appears to double the risk of losing a leg or foot to amputation, a new study reports. People on sodium-glucose cotransporter2 (SGLT2) inhibitors were twice as likely to require a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 15, 2018 Category: General Medicine Source Type: news

Researchers identify a mechanism that fuels cancer cells ’ growth
FINDINGSScientists at theUCLA Jonsson Comprehensive Cancer Center have identified sodium glucose transporter 2, or SGLT2, as a mechanism that lung cancer cells can utilize to obtain glucose, which is key to their survival and promotes tumor growth. The finding provides evidence that SGLT2 may be a novel biomarker that scientists can use to help diagnose precancerous lung lesions and early-stage lung cancers.BACKGROUNDCancer cells require large amounts of glucose to survive and grow. Past research has established that passive glucose transporters, or GLUTs, are the primary means the body uses to deliver glucose to tumors. H...
Source: UCLA Newsroom: Health Sciences - November 15, 2018 Category: Universities & Medical Training Source Type: news

SGLT2 Inhibitor Amputation Risk Seen in Real-World Diabetes Study SGLT2 Inhibitor Amputation Risk Seen in Real-World Diabetes Study
The risk of lower limb amputations and diabetic ketoacidosis associated with use of SGLT2 inhibitors for type 2 diabetes are notable but small, the Scandinavian authors note.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 15, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

For the Good of Your Patients, Use SGLT2 Inhibitors For the Good of Your Patients, Use SGLT2 Inhibitors
Don't let mixed messages about SGLT2 inhibitors and reports of adverse effects deter you from prescribing these drugs, says Per-Henrik Groop.Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 14, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Commentary Source Type: news

Empagliflozin May Reduce LV Mass in Patients With CVD, Diabetes Empagliflozin May Reduce LV Mass in Patients With CVD, Diabetes
EMPA-HEART Cardiolink-6 trial results suggest that the SGLT2 inhibitor is linked to reduced left ventricular mass, a surrogate for reduced heart failure, in patients with CVD and type 2 diabetes.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 13, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

AHA: Mixed Results with Dapagliflozin in T2D Patients
(MedPage Today) -- SGLT2 inhibitor didn't change MACE rate, but did result in other positive CV outcomes (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 10, 2018 Category: Cardiology Source Type: news

DECLARE-TIMI 58: Dapagliflozin Cuts Heart Failure in Diabetes DECLARE-TIMI 58: Dapagliflozin Cuts Heart Failure in Diabetes
The trial did not show a significant reduction in major adverse cardiovascular events but does extend the heart failure benefits of SGLT2 inhibitors to the primary prevention population.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 10, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

Canagliflozin (Invokana) Gets FDA Nod for CV Protection Canagliflozin (Invokana) Gets FDA Nod for CV Protection
The SGLT2 inhibitor is the first oral diabetes medication approved to reduce the risk of cardiovascular events in patients with type 2 diabetes and heart disease.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 31, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

EASE: Empagliflozin Beneficial in Type 1 Diabetes, DKA a Risk EASE: Empagliflozin Beneficial in Type 1 Diabetes, DKA a Risk
Speakers at EASD present divergent risk-benefit analyses for use of SGLT2 inhibitors in type 1 diabetes.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 11, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

SGLT2 Inhibitor-Amputation Link in Diabetes -- Is it Hypovolemia? SGLT2 Inhibitor-Amputation Link in Diabetes -- Is it Hypovolemia?
Observational study finds an increased amputation risk with diuretic use in people with diabetes, suggesting that the hypovolemic mechanism may also explain the amputation risk seen with canagliflozin.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 2, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

DECLARE-TIMI 58: HF Benefit for Dapagliflozin in Diabetes? DECLARE-TIMI 58: HF Benefit for Dapagliflozin in Diabetes?
Top-line data from DECLARE-TIMI 58 hint that CV benefit of the SGLT2 inhibitor dapagliflozin for type 2 diabetes is driven by improvement in heart failure, but 60% of patients were primary prevention.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 25, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

EU Okays CV Benefit Labeling for Canagliflozin in Diabetes EU Okays CV Benefit Labeling for Canagliflozin in Diabetes
The European label for the SGLT2 inhibitor canagliflozin for type 2 diabetes will now include positive cardiovascular benefit results from the CANVAS trial, while a decision from the US FDA is forthcoming.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 21, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

La FDA advierte acerca de casos poco frecuentes de una infecci ón grave del área genital con los inhibidores del SGLT2 para la diabetes
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 7, 2018 Category: Drugs & Pharmacology Source Type: news

La FDA advierte acerca de casos poco frecuentes de una infecci ó n grave del á rea genital con los inhibidores del SGLT2 para la diabetes
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 7, 2018 Category: Drugs & Pharmacology Source Type: news

FDA: Labeling requirements to add 2m hours to medtech industry ’ s regulatory burden
New FDA labeling regulations submitted to the FDA’s Office of Management and Budget are expected to add an additional approximate 1.6 million hours of work to record keepers at the agency and in the industry, according to an FDA notice The added burden comes from changes to the federal watchdog’s medical device labeling regulations, which the agency is actively seeking comments on. With the changes, the agency expects a burden of approximately 3.3 million hours for itself and 9.2 million hours for third-party disclosures, up approximately 1.6 million hours since the last OMB approval, according to the release. ...
Source: Mass Device - September 5, 2018 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Regulatory/Compliance Source Type: news

How One Class Of Diabetes Medications May Lead To Flesh-Eating Genital Infections
If you are taking canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, or any other sodium-glucose cotransporter-2 (SGLT2) inhibitor, you may want to pay attention to this FDA warning. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 1, 2018 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

FDA warns of flesh-eating genital infection linked to diabetes drug
The FDA this week warned of serious flesh-eating bacterial infections, or necrotizing fasciitis, reported by patients taking sodium-glucose cotransporter-2 (SGLT2) inhibitors intended for treating type 2 diabetes. The federal watchdog said that between March 2013 and May 2018, 12 cases of Fournier’s gangrene, a rare but life-threatening bacterial infection of the tissue under the skin that surrounds muscles, nerves, fat and blood vessels of the perineum, were reported by users of the drug. Read the whole story on our sister site, Drug Delivery Business News The post FDA warns of flesh-eating genital infection linked ...
Source: Mass Device - August 31, 2018 Category: Medical Devices Authors: Fink Densford Tags: Diabetes Food & Drug Administration (FDA) Source Type: news

Flesh-eating infection linked to diabetes drugs that killed one and left 11 others hospitalized
Fournier's gangrene - an infection of the scrotum, the penis, or the perineum - has been linked to SGLT2 inhibitors, which lower blood sugar in adults with type 2 diabetes so far infecting 12 people. (Source: the Mail online | Health)
Source: the Mail online | Health - August 30, 2018 Category: Consumer Health News Source Type: news

FDA Warns of Serious Genital Infection With Diabetes Meds
The FDA is warning about rare cases of necrotizing fasciitis – sometimes called “flesh-eating bacteria” -- of the genitals and genital area in patients taking type 2 diabetes drugs known as SGLT2 inhibitors. (Source: WebMD Health)
Source: WebMD Health - August 30, 2018 Category: Consumer Health News Source Type: news

FDA Warns of Common Diabetes Meds', SGLT2 Inhibitors, Link to Dangerous Genital Infection
THURSDAY, Aug. 30, 2018 -- Rare but serious genital infections, as well as one death, have been reported in some patients taking a certain class of type 2 diabetes medicine, the U.S. Food and Drug Administration says. As a result, the FDA has... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 30, 2018 Category: General Medicine Source Type: news

FDA Warns of Serious Genital Infection With SGLT2 Inhibitors FDA Warns of Serious Genital Infection With SGLT2 Inhibitors
The agency has received reports of 12 cases of necrotizing fasciitis of the perineum in patients taking sodium-glucose cotransporter-2 (SGLT2) inhibitors, including five women.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 30, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Alert Source Type: news

FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 29, 2018 Category: Drugs & Pharmacology Source Type: news

SGLT2 Inhibitors and Amputations in Diabetes: Still Unclear SGLT2 Inhibitors and Amputations in Diabetes: Still Unclear
Observational study finds increased risk compared with older oral diabetes medications, but class effect question not addressed.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 15, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Another SGLT2 That You Can Feel Safe Prescribing Another SGLT2 That You Can Feel Safe Prescribing
In regard to amputation risk (and despite a black box warning), it appears that canagliflozin is no less safe than other diabetes drugs.Medscape Internal Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 27, 2018 Category: Consumer Health News Tags: Internal Medicine Commentary Source Type: news

Canagliflozin Renal Outcomes Study Is Halted Early for Efficacy Canagliflozin Renal Outcomes Study Is Halted Early for Efficacy
Hope that observed renoprotective effects of SGLT2 inhibitors will delay worsening of kidney disease in type 2 diabetes seems to be borne out, as the CREDENCE trial is stopped early.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 17, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

SGLT2 Inhibitors: Unreal Primary Prevention? SGLT2 Inhibitors: Unreal Primary Prevention?
These diabetes drugs offer cardiovascular benefits, but only in diabetes patients who already have CV disease, the author argues.Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 15, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Expert Column Source Type: news

Empagliflozin Eyed for Fatty Liver Disease in Type 2 Diabetes Empagliflozin Eyed for Fatty Liver Disease in Type 2 Diabetes
The first trial of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes and nonalcoholic fatty liver disease indicates the drug might reduce liver fat, but the results of the small study need replication.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 22, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news