Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats

In conclusion, the impaired in situ activity of RyR2 may also account for the poor overall cardiac outcome reported in MetS patients; hence, the SERCA pump and RyR2 are both attractive potential targets for future therapies. Introduction Metabolic syndrome (MetS) is a cluster of biochemical and physiological risk factors for cardiovascular disease and diabetes mellitus type 2 (DM2); it represents a severe public health problem around the world (Alberti et al., 2009). Risk factors for MetS include obesity (particularly central obesity), elevated triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C) levels, high blood pressure, and dysglycemia. Insulin resistance is considered to be the critical factor underlying MetS, though the pathogenesis remains unclear (Alberti et al., 2009). The definition of what clinically constitutes MetS has generated considerable debate; however, it is generally accepted that a combination of at least three or more of the risk factors must exist to diagnose MetS (Nolan et al., 2017; Tune et al., 2017). People diagnosed with MetS exhibit delayed heart rate recovery after exercise and 50–60% higher cardiovascular risk than those without it (Sung et al., 2006; Qiao et al., 2007). Specifically, MetS is associated with a twofold increase in cardiovascular mortality, myocardial infarction, and stroke (Mottillo et al., 2010). MetS-associated alterations in heart function include impaired myocardial contractility and diast...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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The interplay of Hypertension, ACE-2 and SARS-CoV-2: Emerging data as the "Ariadne's thread" for the "labyrinth" of COVID-19. Hellenic J Cardiol. 2020 May 22;: Authors: Tsioufis C, Dimitriadis K, Tousoulis D PMID: 32450334 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00864H, CommunicationYoan Chevalier, Yvette Lock Toy Ki, Christian Herrero, Didier Le Nouen, Jean-Pierre Mahy, Jean-Philippe Goddard, Fr édéric Avenier The elusive flavin semiquinone intermediate found in flavoproteins such as cryptochromes has been obtained in aqueous solution by single electron reduction of the natural FMN cofactor using sodium ascorbate. This... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
ConclusionThis study identified the most accurate and reliable machine learning methods, which could enhance the application of radiomics methods in the precision of diagnosis of NPC.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsThe results demonstrate that even subtle changes in vessel morphology can be noninvasively quantified. This is of great interest for AD, but also to other models of neurodegenerative diseases involving macrovascular dysfunction.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsThe new PET radiotracer [18F]AF78 demonstrated high affinity for NET and favourable biodistribution in rats. A structure-activity relationship between radiotracer structures and affinity for NET was revealed, which may serve as the basis for the further design of NET targeting radiotracers with favourable features.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsHypoxia modulation may play a role in nal-IRI ’s mechanism of action. Nal-IRI demonstrated greater anti-tumor activity in the more aggressive and hypoxic tumor model. Furthermore, hypoxia imaging provided early prediction of treatment response.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractThe current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review, we summarize the current status of microfluidic radiosynthesis units for producing fluorine-18 labeled PET imaging tracers, including a discussion of the relative strengths and weaknesses of such devices. In addition, we provide a brief overview of the radiotracers that have been produced using microfluidic devices to ...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsIntegrated [68Ga]PSMA-11 PET/MRI provides a similarly high diagnostic performance for localization of recurrent PC as PET/CT. For the detection of local recurrences [68Ga]PSMA-11 PET/MRI is superior compared with [68Ga]PSMA-11 PET/CT.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractPurposeExisting clinical or microbiological scores are not sensitive enough to obtain prompt identification of patients at risk of complicatedClostridium difficile infection (CDI). Our aim was to use a CDI animal model to evaluate 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography ([18F]FDG-PET) as a marker of severe course of infection.ProceduresCDI was induced with cefoperazone for 10  days followed by clindamycin 1 day beforeC. difficile inoculation. Mice were divided into wild type (n = 6), antibiotic without infection (ACn = 4), h001-infected (n = 5...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
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