Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical model systems, such as PDE4 or PI3Kδ inhibitors (111, 112). Hence, the preclinical pipeline is well developed and will contribute to the growing number of clinical trials in pemphigus and pemphigoid. Author Contributions KI and RL wrote the manuscript. KB prepared the figure. All authors read, commented on, and approved the final version of the manuscript. Funding This work was supported by research grants from the Deutsche Forschungsgemeinschaft: Clinical Research Unit Pemphigoid Diseases (KFO 303), the Excellence Cluster Precision Medicine in Chronic Inflammation (EXC 2167-390884018) and the Uehara Memorial Foundation. Conflict of Interest Statement During the last 3 years, RL has received research funding from Almirall, True North Therapeutics, UCB Pharma, ArgenX, TxCell, Topadur, Incyte and Admirx and fees for consulting or speaking from Arg...
Authors: Carapetis JR, Brown A PMID: 32652580 [PubMed - as supplied by publisher]
Authors: Bondy SC, Campbell A Abstract Melatonin is well known as a neuroendocrine hormone that promotes sleep. However, the many other attributes of melatonin are less apparent and not as widely appreciated. The purpose of this review is to summarize the qualities of melatonin relating to immune function. The relevance of melatonin in partially or wholly restoring optimal function in a series of disorders related to immune dysfunction is addressed. This includes the potential relief of both autoimmune diseases and many other ailments involving abnormal immune responses, including the overall diminished effectivene...
Authors: Brignardello-Petersen R PMID: 32650943 [PubMed - as supplied by publisher]
CONCLUSION: Our modified U-Net with attention unit achieves significantly higher results in terms of Dice score and classification accuracy. The computed BMD and T-score values of the proposed method are also compared with the respective clinical reports for validation. Hence, using the digitized X-Ray images can be used to detect osteoporosis efficiently and accurately. PMID: 32651352 [PubMed - as supplied by publisher]
Publication date: Available online 11 July 2020Source: PeptidesAuthor(s): Dijana Terzic, Nora E. Zois, Ingrid Hunter, Christina Christoffersen, Peter Plomgaard, Lisbeth Høier Olsen, Stine Ringholm, Henriette Pilegaard, Jens P. Goetze
Publication date: Available online 11 July 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Wojciech Żwierełło, Daniel Styburski, Agnieszka Maruszewska, Krzysztof Piorun, Marta Skórka-Majewicz, Maja Czerwińska, Dominika Maciejewska, Irena Baranowska-Bosiacka, Andrzej Krajewski, Izabela Gutowska
Publication date: Available online 12 July 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Sumit Sahni, Christoph Krisp, Mark P. Molloy, Christopher Nahm, Sarah Maloney, Josef Gillson, Anthony J. Gill, Jaswinder Samra, Anubhav Mittal
Analyst, 2020, Accepted Manuscript DOI: 10.1039/D0AN01011A, PaperXiaonan Gao, Congcong Zhao, Keyan Wei, Bo Hu, Yu-Qin Chen, Kehua Xu, Bo Tang The anticancer mechanism for reduced/oxidized ascorbic acid (AA/DHA) is of great significance for clinical cancer therapies. A pH controlled fluorescent nanocarrier was designed to targetable deliver AA and DHA into... The content of this RSS Feed (c) The Royal Society of Chemistry
Authors: Noda Y PMID: 32652489 [PubMed - as supplied by publisher]
CONCLUSION: Our findings identify the left cingulum of cingulate gyrus as a strategic white matter tract for MBNT, suggesting that language - is sensitive to subcortical ischemic damage. Future studies on the role of sporadic ischemic lesions and vascular cognitive impairment should not only focus on total WMH volume but should also take WMH lesion location into account when addressing language. PMID: 32651052 [PubMed - as supplied by publisher]
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