Crohn ’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress

Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress Arno R. Bourgonje1, Julius Z. H. von Martels1, Marian L. C. Bulthuis2, Marco van Londen3, Klaas Nico Faber1, Gerard Dijkstra1† and Harry van Goor2*† 1Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 3Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Introduction: Crohn’s disease (CD) is characterized by chronic and relapsing inflammation of the gastro-intestinal tract. It is assumed that oxidative stress contributes to CD pathogenesis, but systemic biomarkers for oxidative stress in CD are not yet identified. A reduction in free thiol groups in plasma proteins (“plasma free thiols”) reflects systemic oxidative stress since they are prime substrates for reactive oxygen species. Here, we determined the concentrations of plasma free thiols in CD patients and healthy controls and studied the putative correlation with disease parameters. Methods: Free thiols were quantified in plasma of patients with CD in clinical remission [according to the Harvey Bradshaw Index (HBI)] and healthy controls and adjusted for plasma albumin. Albumin-adjusted free thiol conc...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

INTRODUCTION: It remains unclear whether trauma centers are effective for the treatment of injured pediatric patients. The aim of this study was to evaluate children's mortality before and after the establishment a trauma center by using standard mortality...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Individuals diagnosed with attention-deficit/hyperactivity disorder (ADHD) across the life span are at significantly increased risk for a wide range of adverse outcomes, including substance use, obesity, and suicidal behavior. Risky driving, measured in...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Literature has consistently shown a positive relationship between young adults' social media alcohol-related posts and drinking outcomes; however, the reasons for this association and the psychosocial influences behind students' posting of alco...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
In 2015 –2017, the rate of sports, recreation, and leisure injuries among children and adolescents aged 1–17 years was 82.9 per 1,000 population. The rate of sports, recreation, and leisure injuries increased with age from 48.4 for those aged 1–4 y...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
PURPOSE One of the shortcomings of survey trend data on substance use among racial and ethnic groups is not accounting for any criminal history effects. We address this missing piece by examining trends in illicit substance use and binge drinking among th...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
PURPOSE Reciprocal prospective associations between adolescent antisocial behavior and depressive symptoms were examined. Methods Seventh grade students (average age 13  years; N = 2314/2348) were surveyed (T1), and then followed-up 12 (T2) and 24...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Previous research has identified the importance of romantic partners--including spouses, significant others, and dating partners--for influencing the engagement in health-risking behaviors, such as alcohol misuse during emerging adulthood. Although genetic...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Sarah ’s Law, or the Child Sex Offender Disclosure Scheme allows parents, carers and guardians to ask the police to tell them if someone has a criminal record for child sexual offences. Within both the United States and the United Kingdom, laws have be...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Binge drinking accounts for several adverse health, social, legal, and academic outcomes among adolescents. Understanding trends and correlates of binge drinking and alcohol abstention has important implications for policy and programs and was ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
More News: Academia | Acetylcysteine | Alcoholism | Allergy & Immunology | Antidoxidants | Arthritis | Asacol | Biology | Brain | Cardiology | Cardiovascular | Chemistry | Chronic Kidney Disease | Crohn's Disease | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epidemiology | Gastroenterology | Genetics | Germany Health | Grants | Heart | Heart Attack | Heart Failure | Heart Transplant | Inflammatory Bowel Disease | Internal Medicine | Japan Health | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Learning | Lialda | Liver | Liver Disease | Liver Transplant | Lower Endoscopy | Medical Ethics | Mitochondrial Disease | Molecular Biology | Netherlands Health | Neurology | Neuroscience | New Zealand Health | Nutrition | Obesity | Pathology | PET Scan | Physiology | Renal Failure | Reproduction Medicine | Rheumatoid Arthritis | Rheumatology | Smokers | Statistics | Study | Switzerland Health | Transplant Surgery | Transplants | Ulcerative Colitis | Universities & Medical Training | Upper Endoscopy | Urology & Nephrology | USA Health | Vitamin C | Vitamin E | Vitamin E Deficiency | Vitamins