Crohn ’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress
Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress Arno R. Bourgonje1, Julius Z. H. von Martels1, Marian L. C. Bulthuis2, Marco van Londen3, Klaas Nico Faber1, Gerard Dijkstra1† and Harry van Goor2*† 1Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 3Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Introduction: Crohn’s disease (CD) is characterized by chronic and relapsing inflammation of the gastro-intestinal tract. It is assumed that oxidative stress contributes to CD pathogenesis, but systemic biomarkers for oxidative stress in CD are not yet identified. A reduction in free thiol groups in plasma proteins (“plasma free thiols”) reflects systemic oxidative stress since they are prime substrates for reactive oxygen species. Here, we determined the concentrations of plasma free thiols in CD patients and healthy controls and studied the putative correlation with disease parameters. Methods: Free thiols were quantified in plasma of patients with CD in clinical remission [according to the Harvey Bradshaw Index (HBI)] and healthy controls and adjusted for plasma albumin. Albumin-adjusted free thiol conc...
AbstractDante places the sinners who promoted scandals, schism, and discord in the ninth Ditch of the Inferno. Among those is also the Prophet Muhammad. Describing the Prophet ’s punishment, Dante resorts to technical terms and vulgar expressions. This poetic representation highlights Dante’s medical and anatomical knowledge and reflects 14th c. Christian religious beliefs. At that time, autopsies were performed only on prisoners, prostitutes and people without identi ty. By comparing the Prophet to an autopsied corpse, Dante associates Muhammad with those bearing the badge of shame. Moreover, this description ...
Minneapolis is the third-fittest city in the nation, while St. Paul is ranked No. 12. That's according to the 13th annual fitness index study released Tuesday by the American College of Sports Medicine and the Anthem Foundation, which ranked Minneapolis behind Arlington, Va. and Seattle, Wa. out of the 100 largest cities in the country. Scores were compiled via surveys of residen ts across 33 areas like health behaviors (exercise and nutrition habits), prevalence of chronic diseases (obesity,…
Publication date: November 2020Source: Microchemical Journal, Volume 158Author(s): Lina G. Mohtar, Germán A. Messina, Franco A. Bertolino, Sirley V. Pereira, Julio Raba, Mónica A. Nazareno
New J. Chem., 2020, Advance Article DOI: 10.1039/D0NJ02175J, PaperPhanumas Yomthiangthae, Takeshi Kondo, Orawon Chailapakul, Weena Siangproh A simple and modification-free SPCE demonstrated high efficiency for the simultaneous detection of VB2, VB6, and VC in various practical applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Maryam Roza Yazdani, Jarkko Etula, Julie Zimmerman, Ari Sepp älä A new sustainable material for storing heat and releasing it on demand has been demonstrated for long-term latent heat storage (LLHS). The material consists of a high-latent-heat sugar alcohol phase... The content of this RSS Feed (c) The Royal Society of Chemistry
Dalton Trans., 2020, Advance Article DOI: 10.1039/D0DT01963A, PaperD. G. Kellerman, A. P. Tyutyunnik, N. I. Medvedeva, A. Yu. Chufarov, A. D. Fortes, A. S. Gibbs, N. V. Tarakina, M. O. Kalinkin, N. A. Zhuravlev, O. N. Leonidova We discovered a new phase, LiMg6P5O19, in which magnesium can be partially replaced with lithium and scandium in equal amounts. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Cases rise by over 230,000 worldwide in 24 hours; 250,000 people in Manila to return to lockdown; Brazil cases near 2m‘Compelling’ evidence air pollution worsens coronavirus – studyGerman study finds low Covid-19 infection rate in schoolsFauci sidelined as Trump ’s White House steps up briefing campaignBereaved urge EU chief to supervise Italian coronavirus inquiry7.57pmBSTThe Trump administration is increasinglyat war with Anthony Fauci, the federal government ’s top public health expert, over the handling of the epidemic, as the US continues to report around 60,000 new cases a day.In what ap...
Mice that experienced heart attacks underwent a large-scale shift in their immune systems that allowed cancer to flourish, perhaps explaining the observation in patients.
The Association of American Medical Colleges is "concerned and alarmed" by the Trump administration efforts to undercut the U.S.'s top infectious disease expert.
Publication date: Available online 12 July 2020Source: American Journal of Kidney DiseasesAuthor(s): Hélène Lazareth, Hélène Péré, Yannick Binois, Melchior Chabannes, Juliet Schurder, Thomas Bruneau, Alexandre Karras, Eric Thervet, Marion Rabant, David Veyer, Nicolas Pallet
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