Toxoplasma Effector GRA15-Dependent Suppression of IFN- γ-Induced Antiparasitic Response in Human Neurons
Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons Hironori Bando1,2, Youngae Lee1,2, Naoya Sakaguchi1, Ariel Pradipta1, Ryoma Sakamoto1, Shun Tanaka1, Ji Su Ma1,2, Miwa Sasai1,2 and Masahiro Yamamoto1,2* 1Department of Immunoparasitology, Research Institute for Microbial Diseases, Suita, Japan 2Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. The host immune system produces interferon-γ (IFN-γ) to inhibit T. gondii proliferation. IFN-γ-inducible indole-2,3-dioxygenase 1 (IDO1), which mediates tryptophan degradation, has a major role in anti-T. gondii immune responses in various human cells. In response to the host's immune system, T. gondii secretes many virulence molecules into the host cells to suppress IFN-γ-dependent antiparasitic immune responses. The GRA15-induced proparasitic mechanism for suppressing IDO1-dependent immune responses has previously been tested only in human hepatocyte and monocyte co-cultures. Thus, whether human cells other than hepatocytes contain this virulence mechanism remains unclear. Here, we show that the GRA15-dependent virulence mechanism for suppressing the IDO1-dependent anti-T. gondii response operates in human neuronal cell lines and primary human neurons. Analysis of various huma...
AbstractThe novel coronavirus outbreak induces many concerns about the management of pregnancy, as well as rheumatic and musculoskeletal diseases. The very rapid spread of the infection throughout all inhabited continents leads to a fast-growing number of infected with SARS-CoV-2 and requires answers and special recommendations to the most vulnerable group of people: pregnant woman and patients on immunomodulatory or immunosuppressive treatment. A systematic literature search was performed in Embase, MEDLINE, and Scopus database for studies describing COVID-19 infection in pregnant women diagnosed with rheumatic and muscul...
AbstractRepurposing of antirheumatic drugs has garnered global attention. The aim of this article is to overview available evidence on the use of widely used antirheumatic drugs hydroxychloroquine, methotrexate and colchicine for additional indications. Hydroxychloroquine has endothelial stabilizing and anti-thrombotic effects. Its use has been explored as an adjunctive therapy in refractory thrombosis in antiphospholipid syndrome. It may also prevent recurrent pregnancy losses in the absence of antiphospholipid antibodies. Hydroxychloroquine favourably modulates atherogenic lipid and glycaemic profiles. Methotrexate has b...
CONCLUSION: Unclear resection status reduces OS and RFI in patients with OPSCC. Therefore, in surgical therapy, clear resection status in the first pass should be strived for to avoid escalation of adjuvant therapy due to an unclear R status. PMID: 32975607 [PubMed - as supplied by publisher]
Publication date: April 2021Source: Nonlinear Analysis: Real World Applications, Volume 58Author(s): Haijun Hu, Xingfu Zou
Publication date: Available online 26 September 2020Source: Journal of Vascular and Interventional RadiologyAuthor(s): Chan Park, Hee Ho Chu, Jin Hyoung Kim, So Yeon Kim, Ibrahim Alrashidi, Dong Il Gwon, Hyun-Ki Yoon, Nayoung Kim
Publication date: Available online 25 September 2020Source: Social Science &MedicineAuthor(s): Takaaki Ikeda, Jun Aida, Ichiro Kawachi, Katsunori Kondo, Ken Osaka
Authors: Nasifoglu S, Srour J, Lill D, Seegräber M, Sattler E, Schlaak M PMID: 32974719 [PubMed - in process]
[Squamous cell carcinoma with lung metastasis in a young male patient]. Hautarzt. 2020 Jul;71(Suppl 1):44-46 Authors: Lill D, Steinlein O, Engels L, Nasifoglu S, Srour J, Hayani K, Seegräber M, Flaig MJ, Schlaak M, Sattler E PMID: 32974715 [PubMed - in process]
Authors: Rothenberger C, Jakob L, Betke M, French L, Bartsch H, Knösel T, Flaig MJ PMID: 32974710 [PubMed - in process]
Authors: Jastaneyah J, Reffler V, Engels L PMID: 32974706 [PubMed - in process]
More News: Academia | Acute Leukemia | Adenocarcinoma | Allergy & Immunology | Biotechnology | Bone Cancers | Brain | Brain Cancers | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Cervical Cancer | Child Development | Children | Choriocarcinoma | Education | Epidemics | Epidemiology | Epidermoid Carcinoma | Eye Cancers | Eyes | France Health | Genetics | Grants | Hepatitis | Hepatocellular Carcinoma | Infectious Diseases | International Medicine & Public Health | Japan Health | Leiomyosarcoma | Leukemia | Liver | Liver Cancer | Men | Microbiology | Molecular Biology | Neuroblastoma | Neurology | Neuroscience | Osteosarcoma | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Parasitic Diseases | Parasitology | Penicillin | Pregnancy | Reproduction Medicine | Research | Retinoblastoma | Science | Sports Medicine | Statistics | Students | Study | Universities & Medical Training | Urology & Nephrology | USA Health | Vitamin B7 | WHO | Zoonoses