Toxoplasma Effector GRA15-Dependent Suppression of IFN- γ-Induced Antiparasitic Response in Human Neurons
Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons Hironori Bando1,2, Youngae Lee1,2, Naoya Sakaguchi1, Ariel Pradipta1, Ryoma Sakamoto1, Shun Tanaka1, Ji Su Ma1,2, Miwa Sasai1,2 and Masahiro Yamamoto1,2* 1Department of Immunoparasitology, Research Institute for Microbial Diseases, Suita, Japan 2Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. The host immune system produces interferon-γ (IFN-γ) to inhibit T. gondii proliferation. IFN-γ-inducible indole-2,3-dioxygenase 1 (IDO1), which mediates tryptophan degradation, has a major role in anti-T. gondii immune responses in various human cells. In response to the host's immune system, T. gondii secretes many virulence molecules into the host cells to suppress IFN-γ-dependent antiparasitic immune responses. The GRA15-induced proparasitic mechanism for suppressing IDO1-dependent immune responses has previously been tested only in human hepatocyte and monocyte co-cultures. Thus, whether human cells other than hepatocytes contain this virulence mechanism remains unclear. Here, we show that the GRA15-dependent virulence mechanism for suppressing the IDO1-dependent anti-T. gondii response operates in human neuronal cell lines and primary human neurons. Analysis of various huma...
Authors: DiCaprio MR, Abousayed MM, Kambam MLR Abstract Melanoma is an aggressive form of skin cancer associated with significant morbidity and mortality. Although commonly seen in dermatologist clinics, orthopaedic surgeons must be aware of these lesions in various ways. The five common musculoskeletal manifestations of melanoma will be discussed as well as the epidemiology, pathogenesis, diagnosis, staging, treatment, and prognosis of melanoma. With an index of suspicion and awareness of melanoma, a thorough history and detailed physical examination are critical in establishing a diagnosis. An adequately performe...
Publication date: Available online 25 February 2020Source: Reports of Practical Oncology &RadiotherapyAuthor(s): Milan Vošmik, Miroslav Hodek, David Buka, Petra Sýkorová, Jakub Grepl, Petr Paluska, Simona Paulíková, Igor Sirák
Publication date: Available online 26 February 2020Source: Practical Radiation OncologyAuthor(s): Kimberly R. Gergelis, Cole R. Kreofsky, Christopher S. Choo, Jason Viehman, W Scott Harmsen, Scott C. Lester, Thomas M. Pisansky, Brian J. Davis, Bradley J. Stish, Richard Choo
Publication date: April 2020Source: Cancer Genetics, Volume 242Author(s):
Publication date: Available online 26 February 2020Source: Cancer GeneticsAuthor(s): Stewart G. Neill, Jennifer Hauenstein, Marilyn M. Li, Yajuan J Liu, Minjie Luo, Debra F. Saxe, Azra H. Ligon
Publication date: Available online 26 February 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Ben Ponvilawan, Nipith Charoenngam, Thanitsara Rittiphairoj, Patompong Ungprasert
Date: Friday, 02 28, 2020; Speaker: Dr. Weiping Zou, Professor of Pathology, Immunology, Biology&Surgery, University of Michigan School of Medicine; Building: NCI at Frederick, Building 549
CONCLUSION: Ultrasound and MRI have similar diagnostic performance for detecting parametrial infiltration in women with cervical cancer. This might have relevance from the clinical point of view, since ultrasound is cheaper than MRI. PMID: 32096793 [PubMed - as supplied by publisher]
CONCLUSION: By using the combination of ultrasound modes, this approach achieves high performance compared with the single mode and other fusion strategies. Our methodology may be a beneficial tool for the early detection and diagnosis of breast cancer. PMID: 32096788 [PubMed - as supplied by publisher]
CONCLUSIONS: In cases of BCCs with thickness of ≤1 mm, there was a high correlation (r=0.870) of the tumor spread depth between micromorphological measurements and the results obtained using a 75 MHz transducer and in cases of BCCs with thickness of>1 mm, a very high correlation (r=0.951) of the tumor spread depth was observed between histomorphometry and30 MHz transducer measurements. PMID: 32096785 [PubMed - as supplied by publisher]
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