VRK1: a protein that reduces the survival of patients with neuroblastoma
(University of Seville) Researchers have characterised the function of VRK1 in neuroblastoma tumour cells and have determined that this protein is essential for tumour cell growth and proliferation. " By studying the expression of this protein in tumours, we were able to identify a priori patients where tumour progression is going to be worse, even in groups where current tools do not predict that behaviour, " notes Francisco M. Vega. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2020 Category: International Medicine & Public Health Source Type: news

Reductive stress in neuroblastoma cells aggregates protein and impairs neurogenesis
(University of Alabama at Birmingham) Cells require a balance among oxidation-reduction reactions, or redox homeostasis. Loss of that balance to create oxidative stress is often associated with neurodegeneration. Less is known about how loss of that balance at the other end of the spectrum -- reductive stress -- may affect neurons. Now researchers show for the first time that reductive stress promotes protein aggregation in neuroblastoma cells and impairs neurogenesis. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 8, 2020 Category: Biology Source Type: news

Monthly News Roundup - November 2020
Danyelza Gains Accelerated Approval to Treat Neuroblastoma Neuroblastoma is a solid tumor of childhood that occurs in the nervous system outside of the brain. Some tumors are easily treatable, but the majority are aggressive in nature. In... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 30, 2020 Category: Pharmaceuticals Source Type: news

FDA Approves Danyelza (naxitamab-gqgk) for the Treatment of Neuroblastoma
NEW YORK, Nov. 25, 2020 (GLOBE NEWSWIRE) -- Y-mAbs Therapeutics, Inc. (the“Company” or“Y-mAbs”) (Nasdaq: YMAB) a commercial-stage biopharmaceutical company focused on the development and commercialization of novel,... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - November 27, 2020 Category: Drugs & Pharmacology Source Type: news

New Drug Approved for Neuroblastoma Based on MSKCC Research New Drug Approved for Neuroblastoma Based on MSKCC Research
Naxitamab has been approved for pediatric and adult patients with relapsed/refractory neuroblastoma in the bone and bone marrow that has responded to prior therapy.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 26, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA grants accelerated approval to naxitamab for high-risk neuroblastoma in bone or bone marrow
Hematology / Oncology News Burst (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - November 25, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

New immunotherapy shows promise against rare childhood cancer
(University College London) A novel CAR T-cell therapy developed by researchers at UCL and designed to target cancerous tumours, has shown promising early results in children with neuroblastoma, a rare form of childhood cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 25, 2020 Category: International Medicine & Public Health Source Type: news

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
(American Association for the Advancement of Science) A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: news

What Causes Joint Pain?
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory...
Source: PediatricEducation.org - October 26, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Researchers mine data and connect the dots about processes driving neuroblastoma
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital scientists lead genome analysis to better understand one of the most common childhood solid tumors. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 14, 2020 Category: International Medicine & Public Health Source Type: news

Promising treatment for aggressive childhood cancer
(Lund University) A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 6, 2020 Category: Cancer & Oncology Source Type: news

MAX binding with the variant Rs72780850 in RNA helicase DDX1 for susceptibility to neuroblastoma
(Science China Press) The researchers adopted the functional polymorphism research strategy to screen out the functional polymorphisms associated with neuroblastoma in Chinese population and elucidate its mechanism, providing data on children susceptible to neuroblastoma in China. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 11, 2020 Category: Biology Source Type: news

FDA grants rare disease designation to Clarity agent
Radiopharmaceutical firm Clarity Pharmaceuticals announced that the U.S. Food...Read more on AuntMinnie.comRelated Reading: Clarity's breast imaging agent enters clinical trial Clarity begins trial for pediatric neuroblastoma therapy Clarity, ImaginAb team to develop theranostic agents NorthStar inks supply deal with Clarity (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 10, 2020 Category: Radiology Source Type: news

Rozlytrek, Roche ’s first tumour-agnostic therapy, approved in Europe for people with NTRK fusion-positive solid tumours and for people with ROS1-positive advanced non-small cell lung cancer
             Basel, 03 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Commission has granted conditional marketing authorisation for Rozlytrek®(entrectinib) for the treatment of adult and paediatric patients 12 years of age and older with solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor, who have no satisfactory t...
Source: Roche Investor Update - August 3, 2020 Category: Pharmaceuticals Source Type: news

Rozlytrek, Roche ’s first tumour-agnostic therapy, approved in Europe for people with NTRK fusion-positive solid tumours and for people with ROS1-positive advanced non-small cell lung cancer
             Basel, 03 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Commission has granted conditional marketing authorisation for Rozlytrek®(entrectinib) for the treatment of adult and paediatric patients 12 years of age and older with solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor, who have no satisfactory t...
Source: Roche Media News - August 3, 2020 Category: Pharmaceuticals Source Type: news

Clarity's breast imaging agent enters clinical trial
Radiopharmaceutical firm Clarity Pharmaceuticals said that its copper-64 SAR-Bombesin...Read more on AuntMinnie.comRelated Reading: Clarity begins trial for pediatric neuroblastoma therapy Clarity, ImaginAb team to develop theranostic agents NorthStar inks supply deal with Clarity (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 29, 2020 Category: Radiology Source Type: news

Clarity begins trial for pediatric neuroblastoma therapy
Radiopharmaceutical firm Clarity Pharmaceuticals has begun recruitment for...Read more on AuntMinnie.comRelated Reading: Clarity, ImaginAb team to develop theranostic agents NorthStar inks supply deal with Clarity (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 23, 2020 Category: Radiology Source Type: news

Could the willow help us fight cancer?
An ingredient in its bark led to aspirin, now researchers are looking into the properties of another compound in the treeWillow trees are a pharmaceutical treasure trove. The ancient Egyptians used its bark for relieving pain, inflammation and fevers, and science has since shown these medical powers came from an ingredient called salicin, named aftersalix, the Latin name for the tree. That discovery eventually led to the manufacture of aspirin, one of the most widely used medicines in the world.Recently another potential drug has been found in willow, one with anti-cancer powers. Scientists atRothamsted Research in Hertfor...
Source: Guardian Unlimited Science - July 14, 2020 Category: Science Authors: Paul Simons Tags: Science Trees and forests Environment UK news Cancer research Medical research Source Type: news

T1 mapping shows promise for assessing neuroblastoma
The common MRI technique called T1 mapping -- typically used for patients with...Read more on AuntMinnie.comRelated Reading: Imaging shows new, post-SARS-CoV-2 illness in children Preop MRI finds 11% more cancer in women with DCIS PET, MRI uncover women's predisposition to Alzheimer's Imaging reveals baby girl in SC born with 2nd mouth Caution indicated with new GBCAs for kidney patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 1, 2020 Category: Radiology Source Type: news

New radioisotope works better for certain cancers
A new radiopharmaceutical has shown better imaging performance in tumor detection,...Read more on AuntMinnie.comRelated Reading: New radioisotope therapy treats pediatric neuroblastoma Groups ask NRC to allow virtual radiotracer training New tau PET tracer better targets source of Alzheimer's Navidea touts phase IIB study looking at RA New PET/CT tracer reliably detects prostate cancer (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 29, 2020 Category: Radiology Source Type: news

New radioisotope therapy treats pediatric neuroblastoma
Japanese researchers have discovered a new radioisotope therapy for children...Read more on AuntMinnie.comRelated Reading: Researchers link brain tumor treatment to GBCA deposition AJR paper describes errors in pediatric radiography Whole-body MRI has mixed results in pediatric cancer patients Dell donates cloud cluster for pediatric cancer trial Protocols protect pediatric caregivers from I-131 exposure (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 22, 2020 Category: Radiology Source Type: news

A novel radioisotope therapy for children with neuroblastoma
(Kanazawa University) Researchers from Kanazawa University retrospectively analyzed children with refractory or relapsed high-risk neuroblastoma who were treated with high-dose131I-metaiodobenzylguanidine at Kanazawa University Hospital. They showed that within a 5-year period, this therapy could provide a favorable prognosis without severe non-hematological side effects. These findings could provide new insights into a novel treatment option for patients with high-risk neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 19, 2020 Category: Cancer & Oncology Source Type: news

Neuroblastoma: Overview Video Neuroblastoma: Overview Video
This video covers key aspects of neuroblastoma, including the causes, symptoms, diagnosis, and treatment.Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 27, 2020 Category: Consumer Health News Tags: Med Students Commentary Source Type: news

Rice University bioscientist Rosa Uribe wins NSF CAREER Award
(Rice University) Rice University neurodevelopmental biologist Rosa Uribe has won a prestigious CAREER Award from the National Science Foundation to study neural crest cells, specialist stem cells that form the enteric nervous system and also cause neuroblastoma, the third most prevalent form of pediatric cancer in the U.S. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 18, 2020 Category: Biology Source Type: news

Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis
This study highlights the complex allosteric modulation of GPCRs by protein partners and demonstrates how dynamic interactions between GPCRs and their protein partners can control the different steps of highly coordinated cellular processes, such as dendritic tree morphogenesis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 10, 2020 Category: Science Authors: Pujol, C. N., Dupuy, V., Seveno, M., Runtz, L., Bockaert, J., Marin, P., Chaumont-Dubel, S. Tags: STKE Research Articles Source Type: news

New method for monitoring residual disease after treatment in children with neuroblastoma
(Kobe University) Neuroblastoma is a cancer that affects children, characterized by solid tumors that develop from immature nerve cells. Over 50% of patients with high-risk neuroblastoma experience tumor relapse/regrowth.A research group led by Professor NISHIMURA Noriyuki (Graduate School of Health Sciences, Kobe University) has developed a new method to monitor the residual disease after treatment in high-risk neuroblastoma patients. The method could be utilized to evaluate treatment response and facilitate early diagnosis of tumor relapse/regrowth. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 6, 2020 Category: Cancer & Oncology Source Type: news

Boy, six, visited his GP 11 TIMES before diagnosis of the 'largest tumour medics had ever seen'
Ellis Edwards, from Bournemouth, has stage four aggressive neuroblastoma. It was missed on successive trips to the doctors when his parents worried about his weight loss. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2020 Category: Consumer Health News Source Type: news

Smart algorithm finds possible future treatment for childhood cancer
(Uppsala University) Using a computer algorithm, scientists at Uppsala University have identified a promising new treatment for neuroblastoma. This form of cancer in children, which occurs in specialised nerve cells in the sympathetic nervous system, may be life-threatening. In the long term the discovery, described in the latest issue of the scientific journal Nature Communications, may result in a new form of treatment for children in whom the disease is severe or at an advanced stage. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 7, 2020 Category: Cancer & Oncology Source Type: news

Research sheds important light on the metastasis of neuroblastoma
(Children's Cancer Institute Australia) Research sheds important light on the metastasis of neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2019 Category: Cancer & Oncology Source Type: news

Mother shares heartbreaking photo of her toddler undergoing cancer treatment
Sophia Soto, now six, from Florida, was diagnosed with neuroblastoma - a cancer which forms in nerve tissue - at just 14-months-old after tumors were found behind her eyes and on her kidney. (Source: the Mail online | Health)
Source: the Mail online | Health - November 28, 2019 Category: Consumer Health News Source Type: news

A step forward in the struggle against neuroblastoma, a type of childhood cancer
(University of Seville) A protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 27, 2019 Category: Cancer & Oncology Source Type: news

More children survive neuroblastoma
(Princess Máxima Center for Pediatric Oncology) Both the survival rate and the incidence of neuroblastoma have increased in the last decennia in the Netherlands, as was shown by a study from the Princess M á xima Center. The improved chance of survival and the increase in the number of patients has been greatest in the high risk group; children older than 18 months with a stage 4 neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 18, 2019 Category: Cancer & Oncology Source Type: news

Researchers find new way to target childhood cancer
(Children's Cancer Institute Australia) An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 12, 2019 Category: Cancer & Oncology Source Type: news

TTUHSC researchers publish preclinical data on new drug combination to treat neuroblastoma
(Texas Tech University Health Sciences Center) Neuroblastoma, the most common cancer outside of the brain in infants and young children, often fails to respond to therapy. To improve treatment outcomes for these patients, C. Patrick Reynolds, M.D., Ph.D., director of the Texas Tech University Health Sciences Center School of Medicine's Cancer Center, and a team of colleagues completed a study using fenretinide to boost the effects of venetoclax, an inhibitor of a protein (BCL-2) that helps neuroblastoma cells survive and grow. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2019 Category: International Medicine & Public Health Source Type: news

Mother, 20, with back pain is diagnosed with a rare CANCER normally found in children under five 
Lois Parker, of Hatfield, Hertfordshire, was told she had neuroblastoma in September 2018. The cancer affects just 100 children in the UK a year, but Ms Parker was 19. (Source: the Mail online | Health)
Source: the Mail online | Health - November 1, 2019 Category: Consumer Health News Source Type: news

New Treatment Offers Hope for Kids With Deadly Nerve Cancer
THURSDAY, Oct. 10, 2019 -- Early treatment with an immune-boosting therapy might improve the outlook of young children with an advanced form of cancer, a new small study suggests. The trial involved 43 children with high-risk neuroblastoma, a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 10, 2019 Category: General Medicine Source Type: news

4-year-old surprised with "Bumblebees" for his birthday
Whitaker Weinburger has been battling neuroblastoma. So for his fourth birthday, his parents decided to surprise him, and decided to reach out on social media for help. Jan Crawford explains. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - September 12, 2019 Category: Consumer Health News Source Type: news

Algorithm Based on Response, Biology Guides Neuroblastoma Tx
Survival excellent with treatment algorithm for children with intermediate - risk neuroblastoma (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 5, 2019 Category: Cancer & Oncology Tags: Neurology, Oncology, Pathology, Pediatrics, Pharmacy, Radiology, Surgery, Journal, Source Type: news

Algorithm Based on Response, Biology Guides Neuroblastoma Tx
THURSDAY, Sept. 5, 2019 -- Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online Aug. 6 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 5, 2019 Category: Pharmaceuticals Source Type: news

Tandem Autologous Stem-Cell Transplant Boosts Event-Free Neuroblastoma Survival Tandem Autologous Stem-Cell Transplant Boosts Event-Free Neuroblastoma Survival
Tandem autologous stem-cell transplant (ASCT) may provide better event-free survival (EFS) in patients with high-risk neuroblastoma, compared with single ASCT, a new clinical trial shows.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - August 29, 2019 Category: Transplant Surgery Tags: Hematology-Oncology News Source Type: news

New Treatment Approach in Neuroblastoma Proposed New Treatment Approach in Neuroblastoma Proposed
A new oncogene has been identified as a clear driver in the development of neuroblastoma and, as such, could serve as a potential therapeutic target for tumor regression.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 1, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

8-year-old girl survived stage four cancer after doctors 'misread her scans' for three YEARS
Ellie Shoup, eight, from Mounds View, Minnesota, was diagnosed with stage II neuroblastoma at 11 months old. When she was four years old, doctors upgraded her cancer to stage IV. (Source: the Mail online | Health)
Source: the Mail online | Health - June 12, 2019 Category: Consumer Health News Source Type: news

Doctors and nurses celebrate end of chemo for 5-year-old with song
Slater Bushman, 5, is going home healthy after fighting high-risk neuroblastoma for more than 400 days. Doctors and nurses at St. Jude Children's Research Hospital in Memphis celebrated the fact that he's cancer free with a song. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 21, 2019 Category: Consumer Health News Source Type: news

New Experimental Therapy CAR NKT-Cells Tested In Cancer Patients For The First Time
Genetically modified Natural Killer cells have been used in humans for the first time to treat children with relapsed neuroblastoma. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - May 1, 2019 Category: Pharmaceuticals Authors: Victoria Forster, Contributor Source Type: news

LSU Health New Orleans research finds new Rx target for childhood cancer
(Louisiana State University Health Sciences Center) Research led by Michael Lan, Ph.D., Professor of Pediatrics and Genetics at LSU Health New Orleans School of Medicine, found that a compound named 5'-iodotubercidin (5'-IT) suppresses the growth of neuroblastoma cells and identified a potential new therapeutic approach for the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2019 Category: Cancer & Oncology Source Type: news

Proton therapy shows efficacy, low toxicity in large cohort of children with high-risk neuroblastoma
(Children's Hospital of Philadelphia) Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated with proton radiation therapy (PRT), finding both that proton therapy was effective at reducing tumors and demonstrated minimal toxicity to surrounding organs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 9, 2019 Category: International Medicine & Public Health Source Type: news

Toddler is in remission from stage four cancer at just 21 months old
Molly Hughes was diagnosed with neuroblastoma just before she was five months old. Fifteen months and five rounds of surgery later, the Kentucky toddler is cancer-free at last. (Source: the Mail online | Health)
Source: the Mail online | Health - April 5, 2019 Category: Consumer Health News Source Type: news

Kentucky toddler's cancer in remission after long treatment
A 21-month-old Kentucky girl who was diagnosed with Stage 4 neuroblastoma more than a year ago has given her family reason to celebrate _ she is cancer-free (Source: ABC News: Health)
Source: ABC News: Health - April 5, 2019 Category: Consumer Health News Tags: Health Source Type: news

Irish girl, 14, who has been battling cancer for 12 years flies to the US for treatment
Robyn Smyth, 14, from Dublin, Ireland, was diagnosed with neuroblastoma at age three. She's relapsed four times since and the family is now flying to Michigan for treatment. (Source: the Mail online | Health)
Source: the Mail online | Health - March 21, 2019 Category: Consumer Health News Source Type: news

Protein BRCA1 as a stress coach
(University of W ü rzburg) Two proteins work hand in hand to ensure that the tumor cells of neuroblastoma can grow at full speed. In Nature, a W ü rzburg research team shows how the proteins can do this. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 20, 2019 Category: Cancer & Oncology Source Type: news