Cancer drug for children recommended after becoming cost effective for NHS patients
Seriously ill children battling high-risk neuroblastoma, a rare type of cancer that mainly affects children and young people, are to be offered a drug which has potential to extend their lives. (Source: NHS Networks)
Source: NHS Networks - July 12, 2018 Category: UK Health Source Type: news

Child cancer drug approved for NHS use
60% of children with high-risk neuroblastoma can be treated with dinutuximab beta Related items fromOnMedica One in 10 children in phase I cancer trials respond to drugs Children need access to cancer drug ‘goldmine’ NICE rejects adjuvant use of breast cancer drug New breast cancer drug ‘unaffordable’ for NHS Drug could double head and neck cancer survival (Source: OnMedica Latest News)
Source: OnMedica Latest News - July 12, 2018 Category: UK Health Source Type: news

Fluorescent fish genes light path to neuroblastoma
(Rice University) Neurodevelopmental biologist Rosa Uribe, a CPRIT Scholar who was recruited to Rice University in 2017 with a grant from the Cancer Prevention and Research Institute of Texas, has a new tool in the search for the origins of neuroblastoma, the third-most common pediatric cancer in the United States. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 9, 2018 Category: Cancer & Oncology Source Type: news

New model for predicting neuroblastoma outcomes incorporates early developmental signals
(Stowers Institute for Medical Research) Motivated by a desire to better understand the molecular circuitry underlying neuroblastoma and limitations of current methods for predicting disease progression and outcome, researchers from the Kulesa Lab at the Stowers Institute for Medical Research and collaborators at the University of Michigan and Oxford University set out to construct a logic-based model incorporating information about developmental signaling pathways implicated in the disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 6, 2018 Category: Biology Source Type: news

MabVax Therapeutics Grants Exclusive Sublicense to Y-mAbs Therapeutics for Patented Neuroblastoma Vaccine
SAN DIEGO, July 3, 2018 -- (Healthcare Sales & Marketing Network) -- MabVax Therapeutics Holdings, Inc. (Nasdaq: MBVX), a clinical stage oncology drug development company has granted to Y-mAbs Therapeutics, Inc., a privately held clinical stage biopharmac... Biopharmaceuticals, Oncology, Licensing MabVax Therapeutics, Y-mAbs Therapeutics, neuroblastoma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 3, 2018 Category: Pharmaceuticals Source Type: news

Emerging Role of Immunotherapy for Childhood Cancers Emerging Role of Immunotherapy for Childhood Cancers
Immunotherapeutic strategies are showing promise for pediatric cancers such as leukemia and neuroblastoma. What is the latest research?Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 25, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Novel nuclear medicine approach shows promise for treating wide array of cancerous tumors
(Society of Nuclear Medicine and Molecular Imaging) A novel nuclear medicine approach is showing great promise for precision treatment of solid tumors in many types of cancer--including lung, breast, pancreas and ovarian in adults and glioma, neuroblastoma and sarcoma in children. The research was presented today at the SNMMI 2018 Annual Meeting, June 23-26 in Philadelphia. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: news

Researchers create novel combination as potential therapy for high-risk neuroblastoma
(Virginia Commonwealth University) Researchers at VCU Massey Cancer Center in Richmond, Virginia, have identified a promising target to reverse the development of high-risk neuroblastoma and potentially inform the creation of novel combination therapies for the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 18, 2018 Category: International Medicine & Public Health Source Type: news

St Louis Cardinals pitcher reveals his one-year-old daughter is battling  cancer
St Louis Cardinals starting pitcher Alex Reyes, 23, revealed publicly for the first time that his one-year-old daughter Aleyka was diagnosed with neuroblastoma when she was just five months old. (Source: the Mail online | Health)
Source: the Mail online | Health - June 13, 2018 Category: Consumer Health News Source Type: news

Childhood Cancer Impacts Mental Health
WEDNESDAY, June 13, 2018 -- Children with neuroblastoma, a pediatric cancer of nerve cells, are vulnerable to mental health and behavioral problems, a new study finds. Neuroblastoma is diagnosed at a median age of 17.3 months. Treatment advances... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 13, 2018 Category: General Medicine Source Type: news

Childhood Neuroblastoma Survivors at Higher Risk for Psych Disorders
(MedPage Today) -- Chronic health conditions predicted impairment (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - June 13, 2018 Category: Psychiatry Source Type: news

Child Neuroblastoma Survivors at Risk for Psych Impairment
MONDAY, June 11, 2018 -- Neuroblastoma survivors are at elevated risk for psychological impairment, according to a study published online June 11 in Cancer. Daniel J. Zheng, M.D., from Yale University in New Haven, Conn., and colleagues evaluated... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 11, 2018 Category: Pharmaceuticals Source Type: news

Children with neuroblastoma have an elevated risk of long-term psychological difficulties
(Wiley) A new study reveals that pediatric neuroblastoma patients are at elevated risk for long-term psychological impairment. In addition, those who experience such impairment as they get older tend to require special education services and to not go on to college. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 11, 2018 Category: Cancer & Oncology Source Type: news

Transatlantic clinical trial for neuroblastoma is open in UK -- US and Germany to open soon
This study combines 131-I mIBG with Nivolumab and Dinutuximab beta. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 11, 2018 Category: Cancer & Oncology Source Type: news

Decision to not make drug for childhood cancer on NHS 'devastating'
Health watchdog Nice, which advises NHS England, stressed it would like to recommend dinutuximab beta for patients with neuroblastoma – but argued it is too expensive. (Source: the Mail online | Health)
Source: the Mail online | Health - May 4, 2018 Category: Consumer Health News Source Type: news

Decision to not make a drug for childhood cancer on the NHS is 'devastating', say charities
Health watchdog Nice, which advises NHS England, stressed it would like to recommend dinutuximab beta for patients with neuroblastoma – but argued it is too expensive. (Source: the Mail online | Health)
Source: the Mail online | Health - May 4, 2018 Category: Consumer Health News Source Type: news

What Causes Flushing?
Discussion Flushing is usually thought of as a benign condition such as blushing, but can be quite irritating if it is frequent or persistent (i.e. menopausal hot flashes) or even pathologic (i.e. malignancy). “Flushing is a subjective and sensation of warmth that is accompanied by reddening of the skin anywhere on the body but favors the face, neck, and upper torso…. Flushing can be broadly divided into episodic or persistent. Episodic flashing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing result in a fixed facial erythema with telangiectasias and cyan...
Source: PediatricEducation.org - April 30, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Removing the enablers: Reducing number of tumor-supporting cells to fight neuroblastoma
(Children's Hospital Los Angeles) Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages -- a type of immune cell -- can negatively affect the response to chemotherapy against neuroblastoma. Their findings suggest that combination therapy might be effective in patients with high-risk disease, even those who have limited anti-tumor T cell responses. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 23, 2018 Category: Cancer & Oncology Source Type: news

New biomarkers for neuroblastoma, a type of cancer in children
(University of Gothenburg) Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 19, 2018 Category: Cancer & Oncology Source Type: news

Inspiring battle of siblings both diagnosed with cancer
Two of Emily Neumann's children battled cancer. Her son Rowan, seven, was diagnosed with Leukemia and her daughter Winnie, one, was diagnosed with neuroblastoma. (Source: the Mail online | Health)
Source: the Mail online | Health - March 5, 2018 Category: Consumer Health News Source Type: news

Wakefield woman's two sons are diagnosed with cancer
Keri Redfearn, 32, from Wakefield, thought she was living her worst nightmare when her 10-year-old son Leo was diagnosed with neuroblastoma in October last year. (Source: the Mail online | Health)
Source: the Mail online | Health - February 26, 2018 Category: Consumer Health News Source Type: news

Estrogen causes neuroblastoma cells to mature into neurons
(Karolinska Institutet) The female sex hormone estrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children. In laboratory experiments, researchers at Karolinska Institutet in Sweden demonstrate that estrogen treatment and overexpression of the estrogen receptor cause malignant neuroblastoma cells to mature into neuron-like cells. The study, which is published in PNAS, gives hope of new treatment possibilities. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 29, 2018 Category: Cancer & Oncology Source Type: news

'Hijacker' drives cancer in some patients with high-risk neuroblastoma
(St. Jude Children's Research Hospital) Researchers in Memphis and Boston have collaborated to show c-MYC is an oncogene that drives neuroblastoma in some high-risk patients; the findings help set the stage for much-needed precision medicines (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 22, 2018 Category: Biology Source Type: news

Uncovering molecular targets for childhood cancer therapeutics
(Tokyo Medical and Dental University) Neuroblastoma (NB) is the most common solid tumor found in children and is associated with poor prognosis; however, little is known regarding the molecular targets located in the long arm of chromosome 11 (11q). Tokyo Medical and Dental University (TMDU)-centered researchers revealed the loss or imbalance of genes ATM, MRE11A, H2AFX, and/or CHEK1 in 11q in 20.7% of NBs. Furthermore, they found 83.3% NB-derived cell lines exhibited sensitivity to PARP inhibitors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 28, 2017 Category: Cancer & Oncology Source Type: news

Structural basis of membrane disruption and cellular toxicity by {alpha}-synuclein oligomers
Oligomeric species populated during the aggregation process of α-synuclein have been linked to neuronal impairment in Parkinson’s disease and related neurodegenerative disorders. By using solution and solid-state nuclear magnetic resonance techniques in conjunction with other structural methods, we identified the fundamental characteristics that enable toxic α-synuclein oligomers to perturb biological membranes and disrupt cellular function; these include a highly lipophilic element that promotes strong membrane interactions and a structured region that inserts into lipid bilayers and disrupts their integ...
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Fusco, G., Chen, S. W., Williamson, P. T. F., Cascella, R., Perni, M., Jarvis, J. A., Cecchi, C., Vendruscolo, M., Chiti, F., Cremades, N., Ying, L., Dobson, C. M., De Simone, A. Tags: Biochemistry, Neuroscience reports Source Type: news

MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas
Activation of the RAS-RAF-MEK-ERK signaling pathway is implicated in driving the initiation and progression of multiple cancers. Several inhibitors targeting the RAS-MAPK pathway are clinically approved as single- or polyagent therapies for patients with specific types of cancer. One example is the MEK inhibitor trametinib, which is included as a rational polytherapy strategy for treating EML4-ALK–positive, EGFR-activated, or KRAS-mutant lung cancers and neuroblastomas that also contain activating mutations in the RAS-MAPK pathway. In addition, in neuroblastoma, a heterogeneous disease, relapse cases display an incre...
Source: Signal Transduction Knowledge Environment - November 28, 2017 Category: Science Authors: Umapathy, G., Guan, J., Gustafsson, D. E., Javanmardi, N., Cervantes-Madrid, D., Djos, A., Martinsson, T., Palmer, R. H., Hallberg, B. Tags: STKE Research Articles Source Type: news

Thousands of strangers gave a sick 9-year-old an early Christmas. He died days after celebrating.
Jacob Thompson spent nearly half of his short life battling cancer. The 9-year-old boy, who loved penguins, died Sunday, four years after he was diagnosed with Stage 4 neuroblastoma, a rare cancer that affects mostly young children. As his family had expected, Thompson didn’t live long enough to celebrate Christmas, a holiday he loves. But before his death, […]Related:Risk of stillbirth is double in pregnant women who sleep on their backs, study findsA dying vet needed CPR. Hidden video shows his nurse laughing instead.The truth behind the ‘first marijuana overdose death’ headlines (...
Source: Washington Post: To Your Health - November 21, 2017 Category: Consumer Health News Source Type: news

Boy with cancer dies after wish for early Christmas
Jacob Thompson battled neuroblastoma for four years, and people around the world pitched in to bring him joy in his final days (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 20, 2017 Category: Consumer Health News Source Type: news

Thousands of strangers gave a sick child an early Christmas. Days before Thanksgiving, he died.
Jacob Thompson spent nearly half of his short life battling cancer. The 9-year-old boy, who loved penguins, died Sunday, four years after he was diagnosed with Stage 4 neuroblastoma, a rare cancer that affects mostly young children. As his family had expected, Thompson didn’t live long enough for Christmas, a holiday he loves. But shortly before his death, […]Related:Risk of stillbirth is double in pregnant women who sleep on their backs, study findsA dying vet needed CPR. Hidden video shows his nurse laughing instead.The truth behind the ‘first marijuana overdose death’ headlines (S...
Source: Washington Post: To Your Health - November 20, 2017 Category: Consumer Health News Source Type: news

CHLA is awarded more than $1M from St. Baldrick's Foundation to fund cancer research
(Children's Hospital Los Angeles) Three physician-researchers with the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles (CHLA) have been awarded more than $1 million in grants from the St. Baldrick's Foundation, the largest private funder of childhood cancer research. The funding will be used to support research efforts spanning both neuroblastoma and acute lymphoblastic leukemia -- two of the most aggressive childhood cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 14, 2017 Category: Cancer & Oncology Source Type: news

CHLA is awarded more than $1 million from St. Baldrick's Foundation to fund cancer research
(Children's Hospital Los Angeles) Three physician-researchers with the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles (CHLA) have been awarded more than $1 million in grants from the St. Baldrick's Foundation, the largest private funder of childhood cancer research. The funding will be used to support research efforts spanning both neuroblastoma and acute lymphoblastic leukemia -- two of the most aggressive childhood cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 14, 2017 Category: Cancer & Oncology Source Type: news

Fighting Neuroblastoma Like a Superhero
Treatment TermsNeuroblastoma CategoriesChildren's health Author Aliza Inbari Overview VG stands for Vomit Girl, the superhero that Sarah Smith created in her mind when she was a young child undergoing numerous rounds of chemotherapy to treat neuroblastoma, a childhood cancer that develops in the adrenal glands. Hero Imagevg_01.jpg Preview Image Content Blocks Content“Chemotherapy causes patients to vomit frequently so I came up with a superhero for myself: Vomit Girl,” explained Sarah, now a 22-year-old, cancer-free college student. Her best friend’s mom made her a large cape displaying the ...
Source: dukehealth.org: Duke Health News - November 6, 2017 Category: Consumer Health News Authors: dg62 at duke.edu Source Type: news

Two-year-old walks after paralysis from cancer
Z éa Lane, two, was diagnosed with stage 4 neuroblastoma when she was three months old. A surgery to remove the tumor left her paralyzed from the chest down but she now can walk. (Source: the Mail online | Health)
Source: the Mail online | Health - October 31, 2017 Category: Consumer Health News Source Type: news

Leeds United players and staff donate pay to boy's cancer care
Toby Nye was diagnosed with a stage four neuroblastoma on his fourth birthday. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 17, 2017 Category: Consumer Health News Source Type: news

Neuroblastoma in Children Symptoms and Stages
Neuroblastoma (Children -Symptoms and Stages) (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - October 9, 2017 Category: General Medicine Source Type: news

Genomic screening helps doctors target girl's cancer
(Medical University of South Carolina) Two-year-old Victoria Thompson is part of the national precision medicine trial Peds PLAN through MUSC Children's Health for children with high-risk neuroblastoma. She's also receiving DFMO, a drug normally used to treat African sleeping sickness that may help keep high-risk neuroblastoma that's in remission from recurring. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 5, 2017 Category: International Medicine & Public Health Source Type: news

Researchers identify gene variants linked to a high-risk children's cancer
(Children's Hospital of Philadelphia) Pediatric researchers investigating the childhood cancer neuroblastoma have identified common gene variants that raise the risk of an aggressive form of that disease. The discovery may assist doctors in better diagnosing subtypes of neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 25, 2017 Category: Cancer & Oncology Source Type: news

When good immune cells turn bad
(Children's Hospital Los Angeles) Investigators at CHLA have identified the molecular pathway used to foster neuroblastoma and demonstrated use of a clinically available agent, ruxolitinib, to block the pathway. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2017 Category: Cancer & Oncology Source Type: news

Medical News Today: New drug target found for 'most common cancer in infants'
Scientists have found a cell surface protein, which, when targeted using immunotherapy, successfully blocked neuroblastoma from spreading. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 13, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Mayo Clinic researchers identify genes fueling neuroblastoma spread
(Mayo Clinic) For the first time, Mayo Clinic researchers and colleagues present data on how nervous system tumors, called neuroblastomas, spread. Their paper, published in Cancer Cell, clarifies the relationship between two genes that fuel the aggressive spread of neuroblastomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 31, 2017 Category: Cancer & Oncology Source Type: news

CHLA researcher awarded $1.9 million by NIH
(Children's Hospital Los Angeles) Muller Fabbri, MD, PhD, of the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles, has been awarded $1.9 million by the National Cancer Institute of the NIH to further his research on neuroblastoma. The research will focus on a completely new strategy targeting immune cells that contribute to disease progression with a goal toward the development of more potent immunotherapies to improve the outcomes for children with this disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 15, 2017 Category: International Medicine & Public Health Source Type: news

Baby diagnosed with neuroblastoma when doctor ignored lump
Laurel Damour, who lives in Plymouth, Massachusetts, was diagnosed with neuroblastoma on March 10 of this year, just five days after her one year checkup. (Source: the Mail online | Health)
Source: the Mail online | Health - August 4, 2017 Category: Consumer Health News Source Type: news

Hope for childhood cancer that affected Bradley Lowery
Bradley Lowery, six, earned the love of millions worldwide during his widely publicised battle with neuroblastoma before he passed away earlier this month. (Source: the Mail online | Health)
Source: the Mail online | Health - July 27, 2017 Category: Consumer Health News Source Type: news

Nanoparticles loaded with component of common spice kill cancer cells
(University of Central Florida) Attaching curcumin, a component of the common spice turmeric, to nanoparticles can be used to target and destroy treatment-resistant neuroblastoma tumor cells, according to a new study published in Nanoscale. The study, conducted in partnership by researchers at Nemours Children's Hospital and the University of Central Florida, demonstrates a potentially novel treatment for neuroblastoma, the most common cancer in infants. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 25, 2017 Category: Cancer & Oncology Source Type: news

MYCN Copy Number Tied to Poor Features in Neuroblastoma
Patients with MYCN gain had inferior outcomes, including lowest response rate after chemo (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 24, 2017 Category: Cancer & Oncology Tags: Neurology, Nursing, Oncology, Pathology, Pharmacy, Radiology, Surgery, Journal, Source Type: news

The moment cancer-stricken boy dies in his dad's arms
WARNING DISTRESSING CONTENT: Braiden Prescott, seven, from Ince, Greater Manchester died two days after being admitted to a hospice last September having battled neuroblastoma three times. (Source: the Mail online | Health)
Source: the Mail online | Health - June 29, 2017 Category: Consumer Health News Source Type: news

Cancer-stricken boy Braiden Prescott dies in dad's arms
WARNING DISTRESSING CONTENT: Braiden Prescott, seven, from Ince, Greater Manchester died two days after being admitted to a hospice last September having battled neuroblastoma three times. (Source: the Mail online | Health)
Source: the Mail online | Health - June 29, 2017 Category: Consumer Health News Source Type: news

New biomarker assay detects neuroblastoma with greater sensitivity
(Children's Hospital Los Angeles) Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease. Researchers provide the first systematic comparison of standard imaging evaluations versus the new assay that screens for five different neuroblastoma-associated genes and determine that the new assay improves disease assessment and provides prediction of disease progression. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 22, 2017 Category: International Medicine & Public Health Source Type: news

New research points to potential for more targeted treatments of neuroblastoma tumors
(University of Chicago Medical Center) Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 19, 2017 Category: Cancer & Oncology Source Type: news

There's a good reason this last-day-of-school photo is melting hearts
When 7-year-old Sophi Eber began kindergarten, she was in the fight of her young life with stage IV neuroblastoma. She's now cancer-free. (Source: CNN.com - Health)
Source: CNN.com - Health - June 9, 2017 Category: Consumer Health News Source Type: news