Rice University bioscientist Rosa Uribe wins NSF CAREER Award
(Rice University) Rice University neurodevelopmental biologist Rosa Uribe has won a prestigious CAREER Award from the National Science Foundation to study neural crest cells, specialist stem cells that form the enteric nervous system and also cause neuroblastoma, the third most prevalent form of pediatric cancer in the U.S. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 18, 2020 Category: Biology Source Type: news

Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis
This study highlights the complex allosteric modulation of GPCRs by protein partners and demonstrates how dynamic interactions between GPCRs and their protein partners can control the different steps of highly coordinated cellular processes, such as dendritic tree morphogenesis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 11, 2020 Category: Science Authors: Pujol, C. N., Dupuy, V., Seveno, M., Runtz, L., Bockaert, J., Marin, P., Chaumont-Dubel, S. Tags: STKE Research Articles Source Type: news

New method for monitoring residual disease after treatment in children with neuroblastoma
(Kobe University) Neuroblastoma is a cancer that affects children, characterized by solid tumors that develop from immature nerve cells. Over 50% of patients with high-risk neuroblastoma experience tumor relapse/regrowth.A research group led by Professor NISHIMURA Noriyuki (Graduate School of Health Sciences, Kobe University) has developed a new method to monitor the residual disease after treatment in high-risk neuroblastoma patients. The method could be utilized to evaluate treatment response and facilitate early diagnosis of tumor relapse/regrowth. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 6, 2020 Category: Cancer & Oncology Source Type: news

Boy, six, visited his GP 11 TIMES before diagnosis of the 'largest tumour medics had ever seen'
Ellis Edwards, from Bournemouth, has stage four aggressive neuroblastoma. It was missed on successive trips to the doctors when his parents worried about his weight loss. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2020 Category: Consumer Health News Source Type: news

Smart algorithm finds possible future treatment for childhood cancer
(Uppsala University) Using a computer algorithm, scientists at Uppsala University have identified a promising new treatment for neuroblastoma. This form of cancer in children, which occurs in specialised nerve cells in the sympathetic nervous system, may be life-threatening. In the long term the discovery, described in the latest issue of the scientific journal Nature Communications, may result in a new form of treatment for children in whom the disease is severe or at an advanced stage. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 7, 2020 Category: Cancer & Oncology Source Type: news

Research sheds important light on the metastasis of neuroblastoma
(Children's Cancer Institute Australia) Research sheds important light on the metastasis of neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2019 Category: Cancer & Oncology Source Type: news

Mother shares heartbreaking photo of her toddler undergoing cancer treatment
Sophia Soto, now six, from Florida, was diagnosed with neuroblastoma - a cancer which forms in nerve tissue - at just 14-months-old after tumors were found behind her eyes and on her kidney. (Source: the Mail online | Health)
Source: the Mail online | Health - November 28, 2019 Category: Consumer Health News Source Type: news

A step forward in the struggle against neuroblastoma, a type of childhood cancer
(University of Seville) A protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 27, 2019 Category: Cancer & Oncology Source Type: news

More children survive neuroblastoma
(Princess Máxima Center for Pediatric Oncology) Both the survival rate and the incidence of neuroblastoma have increased in the last decennia in the Netherlands, as was shown by a study from the Princess M á xima Center. The improved chance of survival and the increase in the number of patients has been greatest in the high risk group; children older than 18 months with a stage 4 neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 18, 2019 Category: Cancer & Oncology Source Type: news

Researchers find new way to target childhood cancer
(Children's Cancer Institute Australia) An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 12, 2019 Category: Cancer & Oncology Source Type: news

TTUHSC researchers publish preclinical data on new drug combination to treat neuroblastoma
(Texas Tech University Health Sciences Center) Neuroblastoma, the most common cancer outside of the brain in infants and young children, often fails to respond to therapy. To improve treatment outcomes for these patients, C. Patrick Reynolds, M.D., Ph.D., director of the Texas Tech University Health Sciences Center School of Medicine's Cancer Center, and a team of colleagues completed a study using fenretinide to boost the effects of venetoclax, an inhibitor of a protein (BCL-2) that helps neuroblastoma cells survive and grow. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2019 Category: International Medicine & Public Health Source Type: news

Mother, 20, with back pain is diagnosed with a rare CANCER normally found in children under five 
Lois Parker, of Hatfield, Hertfordshire, was told she had neuroblastoma in September 2018. The cancer affects just 100 children in the UK a year, but Ms Parker was 19. (Source: the Mail online | Health)
Source: the Mail online | Health - November 1, 2019 Category: Consumer Health News Source Type: news

New Treatment Offers Hope for Kids With Deadly Nerve Cancer
THURSDAY, Oct. 10, 2019 -- Early treatment with an immune-boosting therapy might improve the outlook of young children with an advanced form of cancer, a new small study suggests. The trial involved 43 children with high-risk neuroblastoma, a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 10, 2019 Category: General Medicine Source Type: news

4-year-old surprised with "Bumblebees" for his birthday
Whitaker Weinburger has been battling neuroblastoma. So for his fourth birthday, his parents decided to surprise him, and decided to reach out on social media for help. Jan Crawford explains. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - September 12, 2019 Category: Consumer Health News Source Type: news

Algorithm Based on Response, Biology Guides Neuroblastoma Tx
Survival excellent with treatment algorithm for children with intermediate - risk neuroblastoma (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 5, 2019 Category: Cancer & Oncology Tags: Neurology, Oncology, Pathology, Pediatrics, Pharmacy, Radiology, Surgery, Journal, Source Type: news

Algorithm Based on Response, Biology Guides Neuroblastoma Tx
THURSDAY, Sept. 5, 2019 -- Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online Aug. 6 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 5, 2019 Category: Pharmaceuticals Source Type: news

Tandem Autologous Stem-Cell Transplant Boosts Event-Free Neuroblastoma Survival Tandem Autologous Stem-Cell Transplant Boosts Event-Free Neuroblastoma Survival
Tandem autologous stem-cell transplant (ASCT) may provide better event-free survival (EFS) in patients with high-risk neuroblastoma, compared with single ASCT, a new clinical trial shows.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - August 30, 2019 Category: Transplant Surgery Tags: Hematology-Oncology News Source Type: news

New Treatment Approach in Neuroblastoma Proposed New Treatment Approach in Neuroblastoma Proposed
A new oncogene has been identified as a clear driver in the development of neuroblastoma and, as such, could serve as a potential therapeutic target for tumor regression.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 1, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

8-year-old girl survived stage four cancer after doctors 'misread her scans' for three YEARS
Ellie Shoup, eight, from Mounds View, Minnesota, was diagnosed with stage II neuroblastoma at 11 months old. When she was four years old, doctors upgraded her cancer to stage IV. (Source: the Mail online | Health)
Source: the Mail online | Health - June 12, 2019 Category: Consumer Health News Source Type: news

Doctors and nurses celebrate end of chemo for 5-year-old with song
Slater Bushman, 5, is going home healthy after fighting high-risk neuroblastoma for more than 400 days. Doctors and nurses at St. Jude Children's Research Hospital in Memphis celebrated the fact that he's cancer free with a song. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 21, 2019 Category: Consumer Health News Source Type: news

New Experimental Therapy CAR NKT-Cells Tested In Cancer Patients For The First Time
Genetically modified Natural Killer cells have been used in humans for the first time to treat children with relapsed neuroblastoma. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - May 1, 2019 Category: Pharmaceuticals Authors: Victoria Forster, Contributor Source Type: news

LSU Health New Orleans research finds new Rx target for childhood cancer
(Louisiana State University Health Sciences Center) Research led by Michael Lan, Ph.D., Professor of Pediatrics and Genetics at LSU Health New Orleans School of Medicine, found that a compound named 5'-iodotubercidin (5'-IT) suppresses the growth of neuroblastoma cells and identified a potential new therapeutic approach for the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2019 Category: Cancer & Oncology Source Type: news

Proton therapy shows efficacy, low toxicity in large cohort of children with high-risk neuroblastoma
(Children's Hospital of Philadelphia) Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated with proton radiation therapy (PRT), finding both that proton therapy was effective at reducing tumors and demonstrated minimal toxicity to surrounding organs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 9, 2019 Category: International Medicine & Public Health Source Type: news

Toddler is in remission from stage four cancer at just 21 months old
Molly Hughes was diagnosed with neuroblastoma just before she was five months old. Fifteen months and five rounds of surgery later, the Kentucky toddler is cancer-free at last. (Source: the Mail online | Health)
Source: the Mail online | Health - April 6, 2019 Category: Consumer Health News Source Type: news

Kentucky toddler's cancer in remission after long treatment
A 21-month-old Kentucky girl who was diagnosed with Stage 4 neuroblastoma more than a year ago has given her family reason to celebrate _ she is cancer-free (Source: ABC News: Health)
Source: ABC News: Health - April 5, 2019 Category: Consumer Health News Tags: Health Source Type: news

Irish girl, 14, who has been battling cancer for 12 years flies to the US for treatment
Robyn Smyth, 14, from Dublin, Ireland, was diagnosed with neuroblastoma at age three. She's relapsed four times since and the family is now flying to Michigan for treatment. (Source: the Mail online | Health)
Source: the Mail online | Health - March 21, 2019 Category: Consumer Health News Source Type: news

Protein BRCA1 as a stress coach
(University of W ü rzburg) Two proteins work hand in hand to ensure that the tumor cells of neuroblastoma can grow at full speed. In Nature, a W ü rzburg research team shows how the proteins can do this. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 20, 2019 Category: Cancer & Oncology Source Type: news

Antibody-drug conjugate shows efficacy against cell surface protein in neuroblastoma
(Children's Hospital of Philadelphia) Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 13, 2019 Category: Biology Source Type: news

Washington girl, 5, cured of cancer after her dentist found her tumor during a routine cleaning
Hunter Jones, five, from Everett, Washington, was diagnosed with neuroblastoma, a cancer that forms in nerve tissue. After 18 months of treatment, she was declared cancer-free. (Source: the Mail online | Health)
Source: the Mail online | Health - March 7, 2019 Category: Consumer Health News Source Type: news

Scientists discover potential way to treat and prevent cancer in children (neuroblastoma)
(Children's Cancer Institute Australia) The MYCN oncogene is known to be a key cause of a number of deadly solid tumour cancers, including neuroblastoma which claims more lives of children under 5 than any other cancer. In new research, a team led by Professor Michelle Haber AM, Executive Director, and Professor Murray Norris AM, Deputy Director, Children's Cancer Institute, Australia, has uncovered a previously unknown crucial link between polyamines and MYCN, offering a new way to target childhood cancers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 1, 2019 Category: International Medicine & Public Health Source Type: news

England rugby stars lead heart-warming campaign for boy, 10, with cancer
Harry Banks, from Bedfordshire, was diagnosed in 2012 with neuroblastoma, a rare cancer which develops from specialised cells left behind from a baby's development in the womb. (Source: the Mail online | Health)
Source: the Mail online | Health - January 23, 2019 Category: Consumer Health News Source Type: news

Devon girl's nightly stomach aches turn out to be rare cancer
Cayla Jones, from Cullompton in Devon, was diagnosed with neuroblastoma last summer and has needed intensive chemotherapy, surgery and radiotherapy to try and tackle it. (Source: the Mail online | Health)
Source: the Mail online | Health - January 14, 2019 Category: Consumer Health News Source Type: news

Four-year-old girl's nightly stomach aches turn out to be rare cancer
Cayla Jones, from Cullompton in Devon, was diagnosed with neuroblastoma last summer and has needed intensive chemotherapy, surgery and radiotherapy to try and tackle it. (Source: the Mail online | Health)
Source: the Mail online | Health - January 14, 2019 Category: Consumer Health News Source Type: news

Donors of Rare Blood Type Sought to Save a Miami Toddler
Zainab Mughal, 2, has cancer. Her treatments depend on frequent blood transfusions, but her blood type is extremely rare. (Source: NYT Health)
Source: NYT Health - January 6, 2019 Category: Consumer Health News Authors: CHRISTINA CARON Tags: Blood Blood Donation Zainab Mughal Indian B antigen Transfusions Neuroblastoma Miami (Fla) Source Type: news

Fourth donor found for two-year-old cancer sufferer with some of 'the rarest blood in the world'
Zainab Mughal's family, who come from Pakistan, have been told she requires transfusions from seven-to-10 donors if she is to have any hope of beating her neuroblastoma. (Source: the Mail online | Health)
Source: the Mail online | Health - January 4, 2019 Category: Consumer Health News Source Type: news

New insights into childhood cancer
(Charit é - Universit ä tsmedizin Berlin) Peripheral nervous system tumors, known as neuroblastoma, are one of the most common types of childhood tumors. As part of an international research endeavor, researchers from Charit é - Universit ä tsmedizin Berlin have studied the genetic factors behind different tumor subtypes and their prognoses. Their findings enable clinicians to predict the precise clinical course of the disease, and to adapt their treatment regimens accordingly. The study has been published in the prestigious journal Science*. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2018 Category: Cancer & Oncology Source Type: news

Search for extremely rare blood donor for 2-year-old with cancer
An international search is underway for donors with an extremely rare blood type to help save a 2-year-old Florida girl battling aggressive cancer. Zainab Mughal was diagnosed with neuroblastoma two months ago. She has one of the rarest blood types in the world. Nikki Battiste reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - December 7, 2018 Category: Consumer Health News Source Type: news

A mechanistic approach to neuroblastoma prognosis and risk
(American Association for the Advancement of Science) A new study reveals key molecular indicators that could help doctors select the best form of treatment for patients with neuroblastoma -- the most common type of cancer in infants. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 6, 2018 Category: Cancer & Oncology Source Type: news

A mechanistic classification of clinical phenotypes in neuroblastoma
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients w...
Source: ScienceNOW - December 6, 2018 Category: Science Authors: Ackermann, S., Cartolano, M., Hero, B., Welte, A., Kahlert, Y., Roderwieser, A., Bartenhagen, C., Walter, E., Gecht, J., Kerschke, L., Volland, R., Menon, R., Heuckmann, J. M., Gartlgruber, M., Hartlieb, S., Henrich, K.-O., Okonechnikov, K., Altmü Tags: Medicine, Diseases reports Source Type: news

PHOTOS: How this $1M donation at Levine Children's Hospital aids treatment of rare cancer
Levine Children's Hospital now has a specialized treatment suite for an aggressive form of childhood cancer, thanks to a $1 million donation from the Isabella Santos Foundation. The suite is equipped for MIBG treatment, which uses radiation to target high-risk neuroblastoma, a tumor typically found in the adrenal glands. The suite is divided into a lead-lined room for the child and a separate room for the parents to prevent unneeded radiation exposure. An audio-video syst em allows communication… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 29, 2018 Category: Biotechnology Authors: Caroline Hudson Source Type: news

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways
In this study, we established both phosphoproteomic and gene expression profiles of ALK activity in neuroblastoma cells exposed to first- and third-generation ALK TKIs, to identify the underlying molecular mechanisms and identify relevant biomarkers, signaling networks, and new therapeutic targets. This analysis has unveiled various important leads for novel combinatorial treatment strategies for patients with neuroblastoma and an increased understanding of ALK signaling involved in this disease. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 20, 2018 Category: Science Authors: Van den Eynden, J., Umapathy, G., Ashouri, A., Cervantes-Madrid, D., Szydzik, J., Ruuth, K., Koster, J., Larsson, E., Guan, J., Palmer, R. H., Hallberg, B. Tags: STKE Research Resources Source Type: news

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma
Oncogenic anaplastic lymphoma kinase (ALK) is one of the few druggable targets in neuroblastoma, and therapy resistance to ALK-targeting tyrosine kinase inhibitors (TKIs) comprises an inevitable clinical challenge. Therefore, a better understanding of the oncogenic signaling network rewiring driven by ALK is necessary to improve and guide future therapies. Here, we performed quantitative mass spectrometry–based proteomics on neuroblastoma cells treated with one of three clinically relevant ALK TKIs (crizotinib, LDK378, or lorlatinib) or an experimentally used ALK TKI (TAE684) to unravel aberrant ALK signaling pathway...
Source: Signal Transduction Knowledge Environment - November 20, 2018 Category: Science Authors: Emdal, K. B., Pedersen, A.-K., Bekker-Jensen, D. B., Lundby, A., Claeys, S., De Preter, K., Speleman, F., Francavilla, C., Olsen, J. V. Tags: STKE Research Resources Source Type: news

Hope for non-toxic treatment for child cancer
Drug combination promising in treating neuroblastoma Related items fromOnMedica One in 10 children in phase I cancer trials respond to drugs Child cancer drug approved for NHS use Children need access to cancer drug ‘goldmine’ Higher heart risk for survivors of childhood cancer Make greater effort to protect children from methadone (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 16, 2018 Category: UK Health Source Type: news

Clinical trial harnesses power of natural killer cells to treat neuroblastoma
(Solving Kids' Cancer) Researchers use a humanized monoclonal antibody known as hu14.18-IL2, which specifically targets neuroblastoma tumor cells and binds to them. The humanized monoclonal antibody may be more effective at activating the NK cells for killing the cancer cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 14, 2018 Category: International Medicine & Public Health Source Type: news

Drug combination makes cancer disappear in mice with neuroblastoma
(ECCO-the European CanCer Organisation) Researchers investigating new treatments for neuroblastoma -- one of the most common childhood cancers -- have found that a combination of two drugs made tumors disappear in mice, making it more effective than any other drugs tested in these animals. The research is presented at the 30th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 14, 2018 Category: Cancer & Oncology Source Type: news

A nine-year-old boy who bravely endured years of gruelling treatment is now free of cancer
Henry Hallam, from Plymouth, was diagnosed with neuroblastoma when he was three years old. It affects 100 UK children each year and has one of the lowest survival rates - but he beat it. (Source: the Mail online | Health)
Source: the Mail online | Health - October 31, 2018 Category: Consumer Health News Source Type: news

Translational research on recurrent metastatic neuroblastoma at Children's Hospital Los Angeles
(Children's Hospital Los Angeles) A team of investigators at CHLA designed basic research studies to look at the effects of dinutuximab and activated natural killer cells on recurrent disease and overall survival in neuroblastoma. This research provided proof-of-concept for an upcoming clinical trial. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 3, 2018 Category: Cancer & Oncology Source Type: news

Could Zika Virus Potentially Treat Neuroblastoma?
Researchers report that the same driving force that makes Zika so detrimental to unborn babies gives it promise as a cancer treatment. (Source: CancerNetwork)
Source: CancerNetwork - August 9, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Girl battling a rare cancer for third time meets Little Mix
Rosie Veronica Mitchell,  Port Glasgow, Inverclyde, is battling neuroblastoma - a rare childhood cancer that usually starts in the abdomen. (Source: the Mail online | Health)
Source: the Mail online | Health - August 8, 2018 Category: Consumer Health News Source Type: news

Urgent appeal is underway to send a six-year-old girl abroad for cancer treatment  
Rosie Veronica Mitchell,  Port Glasgow, Inverclyde, is battling neuroblastoma - a rare childhood cancer that usually starts in the abdomen. (Source: the Mail online | Health)
Source: the Mail online | Health - August 8, 2018 Category: Consumer Health News Source Type: news