CAR T Cells Offer Hope in High-Risk Childhood Neuroblastoma CAR T Cells Offer Hope in High-Risk Childhood Neuroblastoma
Children with relapsed or treatment-refractory neuroblastoma could soon be treated with third-generation of CAR T cells with a ' suicide ' safety switch, after a promising results from phase 1/2 trial.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 6, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Novel treatment shows promise against rare cancer in kids
This December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. In a study published Wednesday, April 5, 2023, in the New England Journal of Medicine, a novel treatment, CAR-T cell therapy, using supercharged immune cells, appears…#mariatsokos #italian #standard #carljune #iv #vatican #bambinogesu #rome #robbiemajzner #francolocatelli (Source: Reuters: Health)
Source: Reuters: Health - April 6, 2023 Category: Consumer Health News Source Type: news
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma
(Source: Reuters: Health)
Source: Reuters: Health - April 6, 2023 Category: Consumer Health News Source Type: news
What are Presentations of Neuroblastoma?
Discussion
Abdominal pain is a very common problem with abdominal masses being somewhat less common. If one considers how frequently patients have abdominal pain due to constipation and that it often presents with a fecal mass, both of these are commonplace. Abdominal and pelvic organs are sometimes mistaken for masses also. As the abdominal and pelvic cavities are large, tumors often need to be quite large before they cause functional problems and/or can be palpated on physical examination.
A review of abdominal masses can be found here.
A review of recurrent abdominal pain can be found here.
A review of acute abdominal p...
Source: PediatricEducation.org - March 27, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
What Causes Mediastinal Masses?
Discussion
The mediastinum resides in the chest and is the space bounded by the thoracic inlet cephalically, diaphragm caudally, sternum anteriorly and transverse process of the spine posteriorly, and mediastinal pleura and lungs laterally. It is divided into various compartments:
Superior mediastinum
Bounded by the thoracic inlet cephalically and a horizontal plane passing from the manubriosternal joint to the junction of T4/T5 vertebrae horizontally.
Structures include: esophagus, trachea, parts of great vessels and first branches, great veins and initial branches, thymus, vagus, phrenic and other nerves, thoracic duct...
Source: PediatricEducation.org - February 20, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Cancer experts back Express campaign for neuroblastoma vaccine research
Leading experts have backed a Daily Express campaign for Britain to fund research into a promising cancer vaccine that could save hundreds of young lives. (Source: Daily Express - Health)
Source: Daily Express - Health - January 16, 2023 Category: Consumer Health News Source Type: news
FDA Panel: All Thumbs Down for Antibody to Treat Metastatic Neuroblastoma
(MedPage Today) -- An FDA advisory committee voted unanimously against recommending approval of the radiolabeled monoclonal antibody 131I-omburtamab for progressive neuroblastoma with central nervous system (CNS)/leptomeningeal metastases.
Citing... (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - October 28, 2022 Category: American Health Source Type: news
What is Ondine ’ s Curse?
Discussion
Congenital central hypoventilation syndrome (CCHS) is an autosomal dominant with variable inheritance genetic disease caused by mutation in the Paired Like Homeobox B2 (PHOX2B) gene on chromosome 4. There are two other genes which may also cause CCHS. CCHS affects the chemoreceptor afferent ventilation pathways and is a neural crest migration problem of the autonomic nervous system. The incidence is unknown but a prevalence of 1 in 200,000 live births has been reported. Obviously it is a rarer phenomenon because of the general lethality of the syndrome.
Patients usually present at birth or soon afterwards, but o...
Source: PediatricEducation.org - August 15, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Neuromics' Human Neurons in Action
Our primary human neurons (cat. HNC001) have been busy lately, continuing to become one of our most popular and versatile products. Earlier this month, Japanese researchers published their findings when creating 3D brain-like spheroids containing our primary human neurons. Their results suggest the spheroids mimic in vivo conditions and are suitable for use as an in vitro neurological disease model. Check out the publication for yourself here.Human Neurons in CultureSince the beginning of 2022, our neurons have been cited a number of times spanning various research are...
Source: Neuromics - July 29, 2022 Category: Neuroscience Source Type: news
'Bridge' Therapy May Benefit Some Kids With High-Risk Neuroblastoma
(MedPage Today) -- Bridge therapy ahead of autologous stem cell transplantation (ASCT) consolidation may benefit certain high-risk neuroblastoma patients with residual disease following induction regimens, according to a multicenter retrospective... (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - June 22, 2022 Category: Hematology Source Type: news
Bridge Therapy Between Induction, ASCT May Slow Neuroblastoma
Three - year event - free survival significantly improved for patients with end - induction stable metastatic disease receiving bridge therapy (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 6, 2022 Category: Cancer & Oncology Tags: Neurology, Oncology, Pathology, Pediatrics, Journal, Source Type: news
Bridge Therapy Between Induction, ASCT May Slow Neuroblastoma
MONDAY, June 6, 2022 -- For patients with high-risk neuroblastoma with end-induction stable metastatic disease, postinduction bridge therapy before autologous stem cell transplantation (ASCT) is associated with better outcomes, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 6, 2022 Category: Pharmaceuticals Source Type: news
Cancer Outcome Disparities Not Fully Explained by Race, Socioeconomic Factors
(MedPage Today) -- Enrollment in clinical trials failed to overcome factors leading to worse survival for Hispanic children with high-risk neuroblastoma, a large retrospective analysis showed.
The Hispanic subgroup had a 5-year overall survival... (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 27, 2022 Category: Hematology Source Type: news
Clarity launching trial for prostate cancer therapy
Clarity Pharmaceuticals is launching an investigator-initiated trial that wil...Read more on AuntMinnie.comRelated Reading:
Clarity hits milestone in study of radiopharmaceutical
NorthStar partners with Clarity, Monopar
FDA grants rare disease designation to Clarity agent
Clarity's breast imaging agent enters clinical trial
Clarity begins trial for pediatric neuroblastoma therapy (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 24, 2022 Category: Radiology Source Type: news
The cancer vaccine that saved our boy should be free on the NHS
WHEN Claire and Mike Scott's three-year-old son was diagnosed with neuroblastoma their world fell apart. Hearts breaking, they had to watch as little Liam went through a whole year of gruelling procedures - chemotherapy, surgery, radiotherapy, immunotherapy and bone marrow treatment. (Source: Daily Express - Health)
Source: Daily Express - Health - February 8, 2022 Category: Consumer Health News Source Type: news
