Marker May Predict Immunotherapy Benefit in High-Risk Neuroblastoma
This video examines how a specific combination of KIR/KIR-ligand genotypes in high-risk neuroblastoma patients may be predictive of outcomes when adding dinutuximab to isotretinoin. (Source: CancerNetwork)
Source: CancerNetwork - April 8, 2017 Category: Cancer & Oncology Authors: Amy K. Erbe, PhD Tags: Conferences/AACR 2017 Brain Tumors Source Type: news

EMA issues positive opinion for EUSA Pharma's Dinutuximab beta to treat neuroblastoma
The European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion in favour of marketing authorisation for EUSA Pharma's antibody ch14.18/CHO, Dinutuximab beta, to treat high-risk neuroblastoma … (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - March 29, 2017 Category: Pharmaceuticals Source Type: news

WATCH: Firefighters shave heads to support colleague's son with cancer
Caleb Lambert, 3, was diagnosed with stage 3 neuroblastoma on Feb. 11. (Source: ABC News: Health)
Source: ABC News: Health - March 27, 2017 Category: Consumer Health News Tags: Lifestyle Source Type: news

Dinutuximab beta receives positive recommendation for the treatment of high-risk neuroblastoma in Europe
HEMEL HEMPSTEAD, England, March 27, 2017 -- (Healthcare Sales & Marketing Network) --EUSA Pharma today announced that the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion in favour of marketin... Biopharmaceuticals, Oncology, Regulatory EUSA Pharma, Dinutuximab beta, neuroblastoma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 27, 2017 Category: Pharmaceuticals Source Type: news

Boy dies of cancer after doctors misdiagnosed tumour
Two-year-old Charlie Round, from Measham, Leicestershire, died on Friday after an aggressive battle with neuroblastoma, a cancer of the nerve cells, after first being told he only had a bump on his head. (Source: the Mail online | Health)
Source: the Mail online | Health - March 26, 2017 Category: Consumer Health News Source Type: news

Dinutuximab for Neuroblastoma and Other EU Decisions Dinutuximab for Neuroblastoma and Other EU Decisions
The Europeans have recommended approval of dinutuximab beta for the treatment of high-risk neuroblastoma, as well as fluciclovine (18F) for use in PET imaging of prostate cancer.International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 24, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

Two investigational antitumor agents work better together against MPNST and neuroblastoma
A new study demonstrates that the combined usage of Aurora A kinase inhibitor (alisertib) and HSV1716 results in significantly increased antitumor efficacy in models of malignant peripheral nerve sheath tumor (MPNST) and neuroblastoma. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 9, 2017 Category: Science Source Type: news

Two investigational antitumor agents work better together against MPNST and neuroblastoma
(Nationwide Children's Hospital) A new study published last week in Oncotarget demonstrates that the combined usage of Aurora A kinase inhibitor (alisertib) and HSV1716 results in significantly increased antitumor efficacy in models of malignant peripheral nerve sheath tumor (MPNST) and neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 9, 2017 Category: Cancer & Oncology Source Type: news

Girl, 2, has melon-sized tumour after family dismissed symptoms as 'stomach bug'  
Lottie Woods-John, from Addlestone, Surrey, was diagnosed with a rare type of childhood cancer, called a neuroblastoma, after going to the hospital with a swollen abdomen. (Source: the Mail online | Health)
Source: the Mail online | Health - December 7, 2016 Category: Consumer Health News Source Type: news

Globe: Braintree Father Builds Drug Company To Battle Son ’ s Cancer
BOSTON (CBS) – A Braintree father whose son was battling neuroblastoma, an especially dangerous form of childhood cancer, teamed with a doctor and some high-powered help to create a drug company dedicated to saving the lives of children. In 2004, Pat and Dina Lacey’s six-month-old baby Will was discovered to have a tumor the size of a baseball in his chest. When Will relapsed at the age of two, the Laceys were told to focus on his quality of life. “Quality of life means how do you want your child to die?” Pat Lacey said in an interview with The Boston Globe. But the Laceys were not going to give up...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 3, 2016 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen Boston Globe Cancer Paula Ebben Will Lacey Source Type: news

More boys are diagnosed with cancer than girls worldwide - why?
This article was originally published on The Conversation. Read the original article. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Science - The Huffington Post)
Source: Science - The Huffington Post - November 25, 2016 Category: Science Source Type: news

Father reveals 4-year-old's "true face of cancer"
One father and photographer revealed the "true face of cancer" through pictures of his 4-year-old daughter battling neuroblastoma. CBSN's Vladimir Duthiers has more of the heartbreaking details. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 22, 2016 Category: Consumer Health News Source Type: news

Child cancer: Dr Ranj Singh discusses Jean-Christophe Novelli’s son’s diagnosis
DR RANJ SINGH has spoken about the signs and symptoms of neuroblastoma after celebrity chef Jean-Christophe Novelli has spoken of his 10-week-old son's fight with cancer on This Morning. (Source: Daily Express - Health)
Source: Daily Express - Health - November 21, 2016 Category: Consumer Health News Source Type: news

Baby who had a cancerous tumour the size of an ORANGE survives after the growth shrunk naturally
Rylee Brady, from Belfast, Northern Ireland, was diagnosed with a neuroblastoma - a rare form of the disease more common in childhood - just days after he was born. (Source: the Mail online | Health)
Source: the Mail online | Health - November 16, 2016 Category: Consumer Health News Source Type: news

Little girl diagnosed with cancer after persistent gastro and fevers
Brisbane girl Violet Box, 7, was diagnosed with neuroblastoma last year. The cancer is one that is hard to detect, and by sharing her story her mother, Colleen, hopes to raise awareness. (Source: the Mail online | Health)
Source: the Mail online | Health - November 15, 2016 Category: Consumer Health News Source Type: news

Nuclear protein causes neuroblastoma to become more aggressive
(University of Rochester Medical Center) Aggressive forms of neuroblastoma contain a specific protein in their cells' nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center, could lead to new forms of targeted therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 6, 2016 Category: Global & Universal Source Type: news

EUSA Pharma Acquires Global Rights to Neuroblastoma Treatment Isqette(R) (Dinutuximab Beta) from Apeiron Biologics
HEMEL HEMPSTEAD, England and VIENNA, October 4, 2016 -- (Healthcare Sales & Marketing Network) -- EUSA Pharma (EUSA), a specialty pharmaceutical company with a focus on oncology and oncology supportive care, today announced the acquisition of exclusive gl... Biopharmaceuticals, Oncology, Acqusitions EUSA Pharma, Apeiron Biologics, Isqette, Dinutuximab, Neuroblastoma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 4, 2016 Category: Pharmaceuticals Source Type: news

Nuclear protein causes neuroblastoma to become more aggressive
Aggressive forms of neuroblastoma contain a specific protein in their cells'nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery could lead to new forms of targeted therapy, say researchers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 29, 2016 Category: Science Source Type: news

Nuclear Protein Causes Neuroblastoma to Become More Aggressive
Aggressive forms of neuroblastoma contain a specific protein in their cells ’ nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery could lead to new forms of targeted therapy. (Source: University of Rochester Medical Center Press Releases)
Source: University of Rochester Medical Center Press Releases - September 27, 2016 Category: Universities & Medical Training Source Type: news

Another Promising Neuroblastoma Discovery
(Source: American Cancer Society :: News and Features)
Source: American Cancer Society :: News and Features - September 1, 2016 Category: Cancer & Oncology Source Type: news

Loss of a microRNA family, let-7, found key in neuroblastoma
(Boston Children's Hospital) A study led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, finds that a microRNA called let-7 plays a central role in curbing neuroblastoma and could focus efforts to find a targeted, nontoxic alternative to chemotherapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 7, 2016 Category: Global & Universal Source Type: news

What Are The Most Common Pediatric Cancers?
Discussion Cancer occurs in all ages including children. Fortunately cancer is much less common in the pediatric age group accounting for
Source: PediatricEducation.org - July 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Tandem myeloablative ASCT consolidation boosts neuroblastoma outcomes
Research presented at the American Society of Clinical Oncology annual conference suggests that consolidation therapy with tandem compared with single myeloablative autologous stem cell transplant can improve outcomes in paediatric patients with high-risk neuroblastoma.  (Source: MedWire News)
Source: MedWire News - June 11, 2016 Category: Consumer Health News Tags: Oncology Source Type: news

Tandem beats single ASCT for childhood neuroblastoma
CHICAGO – More children treated for high-risk neuroblastoma who received a second autologous stem cell transplant in consolidation after induction chemotherapy were alive after 3 years compared with... (Source: Clinical Neurology News)
Source: Clinical Neurology News - June 9, 2016 Category: Neurology Source Type: news

Practice Changer: Tandem Transplant for Neuroblastoma
(MedPage Today) -- 13% absolute increase in 3-year event-free survival (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - June 9, 2016 Category: Hematology Source Type: news

IL-2 adds only toxicity to neuroblastoma antibody tx
CHICAGO – Adding the cytokine IL-2 to front-line therapy with the anti-GD2 antibody ch14.18/CHO provided no additional survival benefit and only added to toxicity in the treatment of pediatric... (Source: Clinical Neurology News)
Source: Clinical Neurology News - June 8, 2016 Category: Neurology Source Type: news

Double Stem Cell Transplant May Help Fight a Childhood Cancer
Tandem treatments might give survival edge to kids with neuroblastoma, researcher saysSource: HealthDay Related MedlinePlus Pages: Cancer Chemotherapy, Neuroblastoma, Stem Cells (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - June 7, 2016 Category: Consumer Health News Source Type: news

Double Stem Cell Transplant May Help Fight a Childhood Cancer
Tandem treatments might give survival edge to kids with neuroblastoma, researcher says (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - June 7, 2016 Category: Cancer & Oncology Source Type: news

Double Stem Cell Transplant May Help Fight a Childhood Cancer
Tandem treatments might give survival edge to kids with neuroblastoma, researcher says (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 7, 2016 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Pediatrics, Research, News, Source Type: news

Immunotherapy, chemotherapy combo effective in children with neuroblastoma
Stephen FellerANN ARBOR, Mich., June 6 (UPI) -- A combination of chemotherapy and immunotherapy shrank or eliminated tumors in more than half of children with recurrent cancer, according to a recent study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 6, 2016 Category: Consumer Health News Source Type: news

Dual stem-cell transplant improves outlook for children with high-risk neuroblastoma
Children with high-risk neuroblastoma whose treatment included two autologous stem-cell transplants were more likely to be free of cancer three years later than patients who underwent a single transplant, a Phase 3 clinical trial has found. The tandem transplant technique produced even better results when followed by treatment with immunotherapy agents. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 6, 2016 Category: Science Source Type: news

High-risk Neuroblastoma: Intensified Therapy Ups SurvivalHigh-risk Neuroblastoma: Intensified Therapy Ups Survival
An intensified 'tandem' myeloablative autologous stem cell transplant regimen has improved survival so much that survivorship issues are now being discussed. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 6, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Doctors unleash new weapon to fight pediatric neuroblastoma
(University of Michigan Health System) After the first year of receiving the novel treatment combination, more than half of children with relapsed neuroblastoma saw either a complete or partial remission -- a 53 percent response rate compared to the typical 10 to 12 percent response rate. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 6, 2016 Category: Cancer & Oncology Source Type: news

Dual stem-cell transplant improves outlook for children with high-risk neuroblastoma
(Dana-Farber Cancer Institute) Children with high-risk neuroblastoma whose treatment included two autologous stem-cell transplants were more likely to be free of cancer three years later than patients who underwent a single transplant, a Phase 3 clinical trial has found, according to research presented at the annual meeting of the American Society of Clinical Oncology. The tandem transplant technique produced even better results when followed by treatment with immunotherapy agents. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 5, 2016 Category: Global & Universal Source Type: news

Immunotherapy Shows Encouraging Results in NeuroblastomaImmunotherapy Shows Encouraging Results in Neuroblastoma
An experimental monoclonal antibody, added to chemotherapy, achieved an 89% response rate in a small early study. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 4, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Investigational immunotherapy drug shrinks tumors in high-risk neuroblastoma patients
Investigators report promising preliminary results for an experimental monoclonal antibody when combined with chemotherapy for newly diagnosed neuroblastoma patients. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 3, 2016 Category: Science Source Type: news

Investigational immunotherapy drug shrinks tumors in high-risk neuroblastoma patients
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital investigators report promising preliminary results at the annual meeting of ASCO for an experimental monoclonal antibody when combined with chemotherapy for newly diagnosed patients. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 3, 2016 Category: Biology Source Type: news

St. Jude Children's Research Hospital research being presented at ASCO Annual Meeting
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital research related to survivorship and the pediatric solid tumors neuroblastoma, adrenocortical carcinoma and nasopharyngeal carcinoma will be presented at the 2016 American Society of Clinical Oncology Annual Meeting. The five-day event begins June 3 in Chicago. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 3, 2016 Category: Cancer & Oncology Source Type: news

Boy diagnosed with constipation actually has cancer and is fighting for life
Daniel Carter, from Hull, was diagnosed with a huge neuroblastoma - a cancer of the cells that form the nervous system - that had spread from his chest to his spine. (Source: the Mail online | Health)
Source: the Mail online | Health - May 26, 2016 Category: Consumer Health News Source Type: news

Oncurious begins Phase I/IIa study of TB-403 to treat medulloblastoma
Oncurious, along with BioInvent International and Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC), has begun a Phase I/IIa study to evaluate the safety, tolerability and preliminary efficacy of TB-403 for the treatment of … (Source: Drug Development Technology)
Source: Drug Development Technology - May 3, 2016 Category: Pharmaceuticals Source Type: news

The effect of explosive blast loading on human neuroblastoma cells - Zander NE, Piehler T, Banton R, Boggs M.
Diagnosis of mild to moderate traumatic brain injury is challenging because brain tissue damage progresses slowly and is not readily detectable by conventional imaging techniques. We have developed a novel in vitro model to study primary blast loading on d... (Source: SafetyLit)
Source: SafetyLit - April 11, 2016 Category: Global & Universal Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Leah Still Celebrates 1 Year of Being Cancer-Free
Leah was diagnosed with neuroblastoma in 2014. (Source: ABC News: Health)
Source: ABC News: Health - March 25, 2016 Category: Consumer Health News Tags: Health Source Type: news

Mother who was left 'infertile' after battling cancer as a child has TRIPLETS
Jaide Ward, 23, from Wigan, was diagnosed with the life threatening condition neuroblastoma, which affects nerve cells, when she was just four years old. (Source: the Mail online | Health)
Source: the Mail online | Health - March 25, 2016 Category: Consumer Health News Source Type: news

Young neuroblastoma patient and family make new home at Dana-Farber/Boston Children’s
Bridgette West sparkled last fall in the “Fight Song” music video, created by patients at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. But before the 2-year-old became a social media standout with her dancing, she and her family faced challenges that went far beyond a cancer diagnosis. In the summer of 2015, after struggling for a year with misdiagnosed illnesses, Bridgette and her parents traveled from their Albany, New York, home to Dana-Farber/Boston Children’s. There, tests confirmed she had neuroblastoma, and while Bridgette started treatment, her parents, Roger and Beth, to...
Source: Thrive, Children's Hospital Boston - March 17, 2016 Category: Pediatrics Authors: Saul Wisnia Tags: Our Patients’ Stories Dana-Farber/Boston Children's Cancer and Blood Disorders Center neuroblastoma Suzanne Shusterman Source Type: news

BioInvent, Oncurious and US research consortium collaborate on TB-403 Phase I/IIa cancer trial
BioInvent International (BINV) and Oncurious have collaborated with the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC) to accelerate a Phase I/IIa trial of TB-403. (Source: Drug Development Technology)
Source: Drug Development Technology - March 16, 2016 Category: Pharmaceuticals Source Type: news

VCU scientists work to bring about a new treatment for rare childhood cancer
(Virginia Commonwealth University) Neuroblastoma is a rare cancer that develops in very early forms of nerve cells in the embryo or fetus, and it accounts for the most pediatric deaths for any tumor outside of the brain. The most lethal form of this tumor is often associated with amplification of the gene MYCN, and now VCU scientists may have developed a combination therapy that uses this gene to kill the cancer, instead of making it grow. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 7, 2016 Category: Cancer & Oncology Source Type: news

My Strength To Battle Cancer Came From The Most Unlikely Source
I was fooled by a 7-year-old into thinking that chemotherapy was easy. In 2006, I was fresh out of journalism school and eager to cover whatever my central Missouri newspaper gig threw at me. When my editor assigned me a story on Tim Grant and what would be his final battle with neuroblastoma, I didn't know what to expect. During my first two-hour ride to the hospital to document one of Tim's chemo sessions, I tried to picture chemotherapy. This was a pre-"50/50" world. When I thought "chemo," I imagined Tim in a steel tube or iron lung being bombarded with cancer-fighting radiation -- which also sapp...
Source: Healthy Living - The Huffington Post - February 3, 2016 Category: Consumer Health News Source Type: news

Leah Wilby was diagnosed with rare neuroblastoma cancer but kept it secret
Leah Wilby, of Great Yarmouth, Norfolk, died from neuroblastoma, rare cancer of nerve cells, at age 16. Her mother said keeping her illness a secret allowed her to live a normal life. (Source: the Mail online | Health)
Source: the Mail online | Health - January 15, 2016 Category: Consumer Health News Source Type: news

[Focus] Beyond static biomarkers—The dynamic response potential of signaling networks as an alternate biomarker?
Properties from simulated pathway dynamics effectively predict neuroblastoma patient outcome. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 23, 2015 Category: Science Authors: Jaeyeon Kim and Birgit Schoeberl Source Type: news

[Research Article] Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients
Patient-specific modeling of a cell death-promoting pathwaymay lead to personalized treatment strategies. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 23, 2015 Category: Science Authors: Dirk Fey, Melinda Halasz, Daniel Dreidax, Sean P. Kennedy, Jordan F. Hastings, Nora Rauch, Amaya Garcia Munoz, Ruth Pilkington, Matthias Fischer, Frank Westermann, Walter Kolch, Boris N. Kholodenko, David R. Croucher Source Type: news