Why United Therapeutics is selling priority review voucher
United Therapeutics (Nasdaq: UTHR) is selling a voucher designed to speed up approval for rare pediatric disease treatments to Chicago-based pharmaceutical company AbbVie Inc. for $350 million.
The Wall Street Journal reports the Silver Spring-based biotechnology company landed the voucher when it received approval from the Food and Drug Administration for Unituxin, its drug designed to treat neuroblastoma.
The voucher is part of an FDA incentive program designed to encourage drug development for… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 19, 2015 Category: Biotechnology Authors: Jennifer Nycz-Conner Source Type: news
Medical News Today: Neuroblastoma cancer cells weaken immune system 'like kryptonite'
A molecule found in the cancer cells of neuroblastoma act like 'kryptonite’ to weaken the body's immune system, a new study reveals, making them lethargic and ineffective. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 3, 2015 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Childhood cancer cells drain immune system's batteries
(Cancer Research UK) Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body's immune cells, leaving them too physically drained to fight the disease, according to new research published in the journal Cancer Research today. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 1, 2015 Category: Global & Universal Source Type: news
Devon Still Accepts Jimmy V Perseverance Award On Behalf Of Daughter Leah
Devon Still accepted the Jimmy V Perseverance Award at the 2015 ESPYs on Wednesday on behalf of his 5-year-old daughter, Leah, who has struggled over the past year with a particularly dangerous form of pediatric cancer. "When my daughter was first diagnosed with cancer, I felt like I was in a nightmare," he told the audience. After thanking his team and his fiancé for standing by him, the Cincinnati Bengals defensive tackle took the time to specifically thank Leah. "I know you wish you could be here, but I know you're watching. I just want to thank you," he said. "From the moment you ...
Source: Healthy Living - The Huffington Post - July 16, 2015 Category: Consumer Health News Source Type: news
New drug for neuroblastoma shows promise in phase I study
(Spectrum Health) Researchers at Spectrum Health Helen DeVos Children's Hospital have completed the first clinical trial of a new treatment for children suffering from neuroblastoma. In a clinical trial led by Giselle Sholler, M.D., and the Neuroblastoma and Medulloblastoma Translational Research Consortium, DFMO, an investigational agent, showed minimal side effects with long-term survival of three patients. This is the first clinical study of an oral dosing form of DFMO in any pediatric population. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 1, 2015 Category: Biology Source Type: news
Pinpointing mutations in a relapsed children's cancer may lead to improved treatments
(Children's Hospital of Philadelphia) Researchers studying the pediatric cancer neuroblastoma have detailed how cancer-driving mutations evolve during chemotherapy, and they hope to exploit this knowledge to design better treatments for children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 29, 2015 Category: Global & Universal Source Type: news
TGen, Dell expand pediatric cancer fight to Europe and Middle East
(The Translational Genomics Research Institute) Dell today announced its extended partnership with the Translational Genomics Research Institute (TGen) to help clinical researchers and doctors globally expand the reach and impact of the world's first FDA-approved precision medicine trial for pediatric cancer. The renewed commitment includes an additional $3 million Dell grant to support continued collaboration with TGen and support the Neuroblastoma and Medulloblastoma Translational Research Consortium's expanded pediatric cancer clinical trials in EMEA, starting with sites in France and Lebanon. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 11, 2015 Category: Cancer & Oncology Source Type: news
Is it Safe to Use G-CSF in Neuroblastoma Patients?Is it Safe to Use G-CSF in Neuroblastoma Patients?
A new study suggests that granulocyte colony-stimulating growth factor (G-CSF) promotes the growth of cancer stem cells within neuroblastoma. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 26, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Green Light for Cancer Immunotherapies in Europe Green Light for Cancer Immunotherapies in Europe
The EU authorities have recommended for approval pembrolizumab for melanoma, nivolumab for lung cancer, and dinutuximab for neuroblastoma. News Alerts (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - May 23, 2015 Category: Cancer & Oncology Tags: Hematology-Oncology News Alert Source Type: news
An Award-Winning Cancer Researcher Says U.S. Science Has Never Been More Imperiled
WASHINGTON -- Around 6:30 p.m. on Wednesday, 150 or so people gathered in an otherwise empty National Press Club in downtown D.C.
Hours earlier, in the room down the hall, Sen. Ted Cruz (R-Texas) had drawn throngs of press during an appearance before the Hispanic Chamber of Commerce. Now, none remained. Instead, attendees still in their work attire sat around tables sipping wine and eating moderately moist chicken dinners, waiting to hear from the guest of the night, a doctor from the Boston Children's Hospital whom few in D.C. -- outside those walls -- knew of.
Dr. Frederick Alt, a 66-year-old Harvard professor of gene...
Source: Science - The Huffington Post - April 30, 2015 Category: Science Source Type: news
[Research Article] Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation
Proteomic analysis of neurotrophin signaling identifies an inhibitory E3 ubiquitin ligase. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 27, 2015 Category: Science Authors: Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Kalliopi P. Tsafou, Heiko Horn, Sven Lindner, Johannes H. Schulte, Angelika Eggert, Lars J. Jensen, Chiara Francavilla, Jesper V. Olsen Source Type: news
Maternal stress increases development of fetal neuroblastoma in animal model
Researchers from Georgetown University Medical Center have shown in mice genetically predisposed to develop neuroblastoma that maternal stress can push onset of the cancer. Their study was presented at the American Association for Cancer Research (AACR) Annual Meeting 2015.
Medical News Today (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 22, 2015 Category: Endocrinology Source Type: news
Maternal stress increases development of fetal neuroblastoma in animal model
While genetics play a substantial role in development of neuroblastoma, scientists say that something else is in play that elevates the risk: stress. Researchers have shown in mice genetically predisposed to develop neuroblastoma that maternal stress can push onset of the cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 21, 2015 Category: Science Source Type: news
A common nerve protein elevated in aggressive neuroblastomas
A protein produced by nerve cells appears to be elevated in the blood of those with an aggressive form of neuroblastoma. The finding could potentially lead to a prognostic test for the disease or be used to monitor its progress. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 20, 2015 Category: Science Source Type: news
Boy beats cancer donning Ninja Turtles costume for bravery
Harley Renshaw, five, from Manchester, is overjoyed to find out he is free of cancer, after battling an aggressive and rare neuroblastoma for a year. He donned a Ninja Turtles mask to feel brave during radiotherapy. (Source: the Mail online | Health)
Source: the Mail online | Health - April 14, 2015 Category: Consumer Health News Source Type: news
