Double Stem Cell Transplant May Help Fight a Childhood Cancer
Tandem treatments might give survival edge to kids with neuroblastoma, researcher says (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 7, 2016 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Pediatrics, Research, News, Source Type: news

Immunotherapy, chemotherapy combo effective in children with neuroblastoma
Stephen FellerANN ARBOR, Mich., June 6 (UPI) -- A combination of chemotherapy and immunotherapy shrank or eliminated tumors in more than half of children with recurrent cancer, according to a recent study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 6, 2016 Category: Consumer Health News Source Type: news

Dual stem-cell transplant improves outlook for children with high-risk neuroblastoma
Children with high-risk neuroblastoma whose treatment included two autologous stem-cell transplants were more likely to be free of cancer three years later than patients who underwent a single transplant, a Phase 3 clinical trial has found. The tandem transplant technique produced even better results when followed by treatment with immunotherapy agents. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 6, 2016 Category: Science Source Type: news

High-risk Neuroblastoma: Intensified Therapy Ups SurvivalHigh-risk Neuroblastoma: Intensified Therapy Ups Survival
An intensified 'tandem' myeloablative autologous stem cell transplant regimen has improved survival so much that survivorship issues are now being discussed. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 6, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Doctors unleash new weapon to fight pediatric neuroblastoma
(University of Michigan Health System) After the first year of receiving the novel treatment combination, more than half of children with relapsed neuroblastoma saw either a complete or partial remission -- a 53 percent response rate compared to the typical 10 to 12 percent response rate. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 6, 2016 Category: Cancer & Oncology Source Type: news

Dual stem-cell transplant improves outlook for children with high-risk neuroblastoma
(Dana-Farber Cancer Institute) Children with high-risk neuroblastoma whose treatment included two autologous stem-cell transplants were more likely to be free of cancer three years later than patients who underwent a single transplant, a Phase 3 clinical trial has found, according to research presented at the annual meeting of the American Society of Clinical Oncology. The tandem transplant technique produced even better results when followed by treatment with immunotherapy agents. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 5, 2016 Category: Global & Universal Source Type: news

Immunotherapy Shows Encouraging Results in NeuroblastomaImmunotherapy Shows Encouraging Results in Neuroblastoma
An experimental monoclonal antibody, added to chemotherapy, achieved an 89% response rate in a small early study. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 4, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Investigational immunotherapy drug shrinks tumors in high-risk neuroblastoma patients
Investigators report promising preliminary results for an experimental monoclonal antibody when combined with chemotherapy for newly diagnosed neuroblastoma patients. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 3, 2016 Category: Science Source Type: news

Investigational immunotherapy drug shrinks tumors in high-risk neuroblastoma patients
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital investigators report promising preliminary results at the annual meeting of ASCO for an experimental monoclonal antibody when combined with chemotherapy for newly diagnosed patients. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 3, 2016 Category: Biology Source Type: news

St. Jude Children's Research Hospital research being presented at ASCO Annual Meeting
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital research related to survivorship and the pediatric solid tumors neuroblastoma, adrenocortical carcinoma and nasopharyngeal carcinoma will be presented at the 2016 American Society of Clinical Oncology Annual Meeting. The five-day event begins June 3 in Chicago. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 3, 2016 Category: Cancer & Oncology Source Type: news

Boy diagnosed with constipation actually has cancer and is fighting for life
Daniel Carter, from Hull, was diagnosed with a huge neuroblastoma - a cancer of the cells that form the nervous system - that had spread from his chest to his spine. (Source: the Mail online | Health)
Source: the Mail online | Health - May 26, 2016 Category: Consumer Health News Source Type: news

Oncurious begins Phase I/IIa study of TB-403 to treat medulloblastoma
Oncurious, along with BioInvent International and Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC), has begun a Phase I/IIa study to evaluate the safety, tolerability and preliminary efficacy of TB-403 for the treatment of … (Source: Drug Development Technology)
Source: Drug Development Technology - May 3, 2016 Category: Pharmaceuticals Source Type: news

The effect of explosive blast loading on human neuroblastoma cells - Zander NE, Piehler T, Banton R, Boggs M.
Diagnosis of mild to moderate traumatic brain injury is challenging because brain tissue damage progresses slowly and is not readily detectable by conventional imaging techniques. We have developed a novel in vitro model to study primary blast loading on d... (Source: SafetyLit)
Source: SafetyLit - April 11, 2016 Category: Global & Universal Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Leah Still Celebrates 1 Year of Being Cancer-Free
Leah was diagnosed with neuroblastoma in 2014. (Source: ABC News: Health)
Source: ABC News: Health - March 25, 2016 Category: Consumer Health News Tags: Health Source Type: news

Mother who was left 'infertile' after battling cancer as a child has TRIPLETS
Jaide Ward, 23, from Wigan, was diagnosed with the life threatening condition neuroblastoma, which affects nerve cells, when she was just four years old. (Source: the Mail online | Health)
Source: the Mail online | Health - March 25, 2016 Category: Consumer Health News Source Type: news

Young neuroblastoma patient and family make new home at Dana-Farber/Boston Children’s
Bridgette West sparkled last fall in the “Fight Song” music video, created by patients at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. But before the 2-year-old became a social media standout with her dancing, she and her family faced challenges that went far beyond a cancer diagnosis. In the summer of 2015, after struggling for a year with misdiagnosed illnesses, Bridgette and her parents traveled from their Albany, New York, home to Dana-Farber/Boston Children’s. There, tests confirmed she had neuroblastoma, and while Bridgette started treatment, her parents, Roger and Beth, to...
Source: Thrive, Children's Hospital Boston - March 17, 2016 Category: Pediatrics Authors: Saul Wisnia Tags: Our Patients’ Stories Dana-Farber/Boston Children's Cancer and Blood Disorders Center neuroblastoma Suzanne Shusterman Source Type: news

BioInvent, Oncurious and US research consortium collaborate on TB-403 Phase I/IIa cancer trial
BioInvent International (BINV) and Oncurious have collaborated with the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC) to accelerate a Phase I/IIa trial of TB-403. (Source: Drug Development Technology)
Source: Drug Development Technology - March 16, 2016 Category: Pharmaceuticals Source Type: news

VCU scientists work to bring about a new treatment for rare childhood cancer
(Virginia Commonwealth University) Neuroblastoma is a rare cancer that develops in very early forms of nerve cells in the embryo or fetus, and it accounts for the most pediatric deaths for any tumor outside of the brain. The most lethal form of this tumor is often associated with amplification of the gene MYCN, and now VCU scientists may have developed a combination therapy that uses this gene to kill the cancer, instead of making it grow. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 7, 2016 Category: Cancer & Oncology Source Type: news

My Strength To Battle Cancer Came From The Most Unlikely Source
I was fooled by a 7-year-old into thinking that chemotherapy was easy. In 2006, I was fresh out of journalism school and eager to cover whatever my central Missouri newspaper gig threw at me. When my editor assigned me a story on Tim Grant and what would be his final battle with neuroblastoma, I didn't know what to expect. During my first two-hour ride to the hospital to document one of Tim's chemo sessions, I tried to picture chemotherapy. This was a pre-"50/50" world. When I thought "chemo," I imagined Tim in a steel tube or iron lung being bombarded with cancer-fighting radiation -- which also sapp...
Source: Healthy Living - The Huffington Post - February 3, 2016 Category: Consumer Health News Source Type: news

Leah Wilby was diagnosed with rare neuroblastoma cancer but kept it secret
Leah Wilby, of Great Yarmouth, Norfolk, died from neuroblastoma, rare cancer of nerve cells, at age 16. Her mother said keeping her illness a secret allowed her to live a normal life. (Source: the Mail online | Health)
Source: the Mail online | Health - January 15, 2016 Category: Consumer Health News Source Type: news

[Focus] Beyond static biomarkers—The dynamic response potential of signaling networks as an alternate biomarker?
Properties from simulated pathway dynamics effectively predict neuroblastoma patient outcome. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 23, 2015 Category: Science Authors: Jaeyeon Kim and Birgit Schoeberl Source Type: news

[Research Article] Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients
Patient-specific modeling of a cell death-promoting pathwaymay lead to personalized treatment strategies. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 23, 2015 Category: Science Authors: Dirk Fey, Melinda Halasz, Daniel Dreidax, Sean P. Kennedy, Jordan F. Hastings, Nora Rauch, Amaya Garcia Munoz, Ruth Pilkington, Matthias Fischer, Frank Westermann, Walter Kolch, Boris N. Kholodenko, David R. Croucher Source Type: news

American Cancer Society awards 'Shine A Light' Funds to neuroblastoma researcher
(American Cancer Society) The American Cancer Society has selected Dr. Andras Heczey of Texas Children's Cancer Center as the recipient of a four-year grant funded by TODAY Show viewers through its 'Shine A Light' campaign. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 16, 2015 Category: Cancer & Oncology Source Type: news

New Hope for Kids with Neuroblastoma
(Source: American Cancer Society :: News and Features)
Source: American Cancer Society :: News and Features - December 15, 2015 Category: Cancer & Oncology Source Type: news

Grant to CHOP funds personalized treatments for children with neuroblastoma
(Children's Hospital of Philadelphia) A new $1.5 million grant to The Children's Hospital of Philadelphia from Alex's Lemonade Stand Foundation supports an innovative approach to treating relapsed or refractory neuroblastoma, a high-risk childhood cancer. CHOP researchers are launching a pediatric clinical trial with a dynamic design allowing them to quickly incorporate new treatments by matching gene changes in an individual patient's tumor to available drugs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2015 Category: Cancer & Oncology Source Type: news

Change in a single DNA base drives a childhood cancer
(Children's Hospital of Philadelphia) Pediatric oncology researchers have pinpointed a crucial change in a single DNA base that both predisposes children to an aggressive form of the childhood cancer neuroblastoma and makes the disease progress once tumors form. The gene change results in a 'super enhancer' that drives the cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 11, 2015 Category: Cancer & Oncology Source Type: news

Promising results in study of pediatric neuroblastoma
Scientists have identified a new treatment approach for a highly aggressive and usually fatal subtype of neuroblastoma. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 6, 2015 Category: Science Source Type: news

A way to target the Achilles heel of neuroblastoma
(Children's Cancer Institute Australia) Australian scientists have identified a critical molecular 'feedback loop' that helps initiate and drive neuroblastoma, a cancer of the nervous system in children that is triggered in embryonal nerve cells. The research team have also identified an experimental drug, currently in clinical trials for adult cancer, with the potential to interrupt the loop and halt tumor progression. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 4, 2015 Category: Cancer & Oncology Source Type: news

Childhood cancer: ‘Little Miss Sunshine’ who beat her aggressive disease
IN RECENT weeks viewers of Coronation Street have seen actress Jennie McAlpine’s character, Fiz Stape, plunged into a nightmare as her five-year-old daughter Hope battles neuroblastoma, an aggressive childhood cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - November 2, 2015 Category: Consumer Health News Source Type: news

Medical News Today: Blastoma: Causes, Diagnosis and Treatments
Find out what blastoma is and about its numerous types such as neuroblastoma and hepatoblastoma. Also learn how blastomas are almost always treatable. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 28, 2015 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Cancer-driving signals cause high-risk neuroblastoma
Researchers have discovered details of the abnormal molecular signals and biological events that drive a high-risk form of the childhood cancer neuroblastoma. Having investigated a signaling network involving three cancer-causing genes, the scientists aim to use these findings to develop more effective targeted treatments. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 15, 2015 Category: Science Source Type: news

Cancer-driving signals cause high-risk neuroblastoma
(Children's Hospital of Philadelphia) Researchers have discovered details of the abnormal molecular signals and biological events that drive a high-risk form of the childhood cancer neuroblastoma. Having investigated a signaling network involving three cancer-causing genes, the scientists aim to use these findings to develop more effective targeted treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 15, 2015 Category: Cancer & Oncology Source Type: news

Analyses of Tumor Burden In Vivo and Metastasis Ex Vivo Using Luciferase-Expressing Cancer Cells in an Orthotopic Mouse Model of Neuroblastoma
Cancer xenograft mouse models are useful for examining and understanding tumor growth and cancer progression in vivo. With the development of bioluminescent imaging, these parameters can now be monitored noninvasively with relative ease. Herein we describe imaging of luciferase-expressing cancer cells to quantitatively measure tumor burden in vivo and metastases ex vivo. Specifically, we detail the methodology to examine the effect of shRNA-mediated knockdown of a target gene on the growth and spread of neuroblastoma tumors in immune-deficient mice. (Source: Springer protocols feed by Imaging/Radiology)
Source: Springer protocols feed by Imaging/Radiology - October 11, 2015 Category: Radiology Source Type: news

Orphan-Drug Designation From FDA And Positive Scientific Advice From EMA
Ability Pharmaceuticals, a drug development biopharmaceutical company specialized in oncology, recently announced that it has received from the U.S. Food and Drug Administration (FDA), orphan-drug designation (ODD) for ABTL0812, its PI3K/Akt/mTOR pathway inhibitor, for the treatment of the pediatric cancer neuroblastoma and that it has received positive Scientific Advice from the European Medicines Agency (EMA) for its development in the same indication. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - October 9, 2015 Category: Pharmaceuticals Source Type: news

Rosannah Searle with tumour the size of a soccer ball and weighing 8 kilos
Rosannah Searle, from Baradine, NSW, was diagnosed with stage three neuroblastoma at just three months old. (Source: the Mail online | Health)
Source: the Mail online | Health - September 15, 2015 Category: Consumer Health News Source Type: news

Why United Therapeutics is selling priority review voucher
United Therapeutics (Nasdaq: UTHR) is selling a voucher designed to speed up approval for rare pediatric disease treatments to Chicago-based pharmaceutical company AbbVie Inc. for $350 million. The Wall Street Journal reports the Silver Spring-based biotechnology company landed the voucher when it received approval from the Food and Drug Administration for Unituxin, its drug designed to treat neuroblastoma. The voucher is part of an FDA incentive program designed to encourage drug development for… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 19, 2015 Category: Biotechnology Authors: Jennifer Nycz-Conner Source Type: news

Medical News Today: Neuroblastoma cancer cells weaken immune system 'like kryptonite'
A molecule found in the cancer cells of neuroblastoma act like 'kryptonite’ to weaken the body's immune system, a new study reveals, making them lethargic and ineffective. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 3, 2015 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Childhood cancer cells drain immune system's batteries
(Cancer Research UK) Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body's immune cells, leaving them too physically drained to fight the disease, according to new research published in the journal Cancer Research today. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 1, 2015 Category: Global & Universal Source Type: news

Devon Still Accepts Jimmy V Perseverance Award On Behalf Of Daughter Leah
  Devon Still accepted the Jimmy V Perseverance Award at the 2015 ESPYs on Wednesday on behalf of his 5-year-old daughter, Leah, who has struggled over the past year with a particularly dangerous form of pediatric cancer.  "When my daughter was first diagnosed with cancer, I felt like I was in a nightmare," he told the audience. After thanking his team and his fiancé for standing by him, the Cincinnati Bengals defensive tackle took the time to specifically thank Leah.  "I know you wish you could be here, but I know you're watching. I just want to thank you," he said....
Source: Healthy Living - The Huffington Post - July 16, 2015 Category: Consumer Health News Source Type: news

New drug for neuroblastoma shows promise in phase I study
(Spectrum Health) Researchers at Spectrum Health Helen DeVos Children's Hospital have completed the first clinical trial of a new treatment for children suffering from neuroblastoma. In a clinical trial led by Giselle Sholler, M.D., and the Neuroblastoma and Medulloblastoma Translational Research Consortium, DFMO, an investigational agent, showed minimal side effects with long-term survival of three patients. This is the first clinical study of an oral dosing form of DFMO in any pediatric population. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 1, 2015 Category: Biology Source Type: news

Pinpointing mutations in a relapsed children's cancer may lead to improved treatments
(Children's Hospital of Philadelphia) Researchers studying the pediatric cancer neuroblastoma have detailed how cancer-driving mutations evolve during chemotherapy, and they hope to exploit this knowledge to design better treatments for children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 29, 2015 Category: Global & Universal Source Type: news

TGen, Dell expand pediatric cancer fight to Europe and Middle East
(The Translational Genomics Research Institute) Dell today announced its extended partnership with the Translational Genomics Research Institute (TGen) to help clinical researchers and doctors globally expand the reach and impact of the world's first FDA-approved precision medicine trial for pediatric cancer. The renewed commitment includes an additional $3 million Dell grant to support continued collaboration with TGen and support the Neuroblastoma and Medulloblastoma Translational Research Consortium's expanded pediatric cancer clinical trials in EMEA, starting with sites in France and Lebanon. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 11, 2015 Category: Cancer & Oncology Source Type: news

Is it Safe to Use G-CSF in Neuroblastoma Patients?Is it Safe to Use G-CSF in Neuroblastoma Patients?
A new study suggests that granulocyte colony-stimulating growth factor (G-CSF) promotes the growth of cancer stem cells within neuroblastoma. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 26, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Green Light for Cancer Immunotherapies in Europe Green Light for Cancer Immunotherapies in Europe
The EU authorities have recommended for approval pembrolizumab for melanoma, nivolumab for lung cancer, and dinutuximab for neuroblastoma. News Alerts (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - May 23, 2015 Category: Cancer & Oncology Tags: Hematology-Oncology News Alert Source Type: news

An Award-Winning Cancer Researcher Says U.S. Science Has Never Been More Imperiled
WASHINGTON -- Around 6:30 p.m. on Wednesday, 150 or so people gathered in an otherwise empty National Press Club in downtown D.C. Hours earlier, in the room down the hall, Sen. Ted Cruz (R-Texas) had drawn throngs of press during an appearance before the Hispanic Chamber of Commerce. Now, none remained. Instead, attendees still in their work attire sat around tables sipping wine and eating moderately moist chicken dinners, waiting to hear from the guest of the night, a doctor from the Boston Children's Hospital whom few in D.C. -- outside those walls -- knew of. Dr. Frederick Alt, a 66-year-old Harvard professor of gene...
Source: Science - The Huffington Post - April 30, 2015 Category: Science Source Type: news

[Research Article] Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation
Proteomic analysis of neurotrophin signaling identifies an inhibitory E3 ubiquitin ligase. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 27, 2015 Category: Science Authors: Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Kalliopi P. Tsafou, Heiko Horn, Sven Lindner, Johannes H. Schulte, Angelika Eggert, Lars J. Jensen, Chiara Francavilla, Jesper V. Olsen Source Type: news

Maternal stress increases development of fetal neuroblastoma in animal model
Researchers from Georgetown University Medical Center have shown in mice genetically predisposed to develop neuroblastoma that maternal stress can push onset of the cancer. Their study was presented at the American Association for Cancer Research (AACR) Annual Meeting 2015. Medical News Today (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 22, 2015 Category: Endocrinology Source Type: news

Maternal stress increases development of fetal neuroblastoma in animal model
While genetics play a substantial role in development of neuroblastoma, scientists say that something else is in play that elevates the risk: stress. Researchers have shown in mice genetically predisposed to develop neuroblastoma that maternal stress can push onset of the cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 21, 2015 Category: Science Source Type: news

A common nerve protein elevated in aggressive neuroblastomas
A protein produced by nerve cells appears to be elevated in the blood of those with an aggressive form of neuroblastoma. The finding could potentially lead to a prognostic test for the disease or be used to monitor its progress. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 20, 2015 Category: Science Source Type: news

Boy beats cancer donning Ninja Turtles costume for bravery
Harley Renshaw, five, from Manchester, is overjoyed to find out he is free of cancer, after battling an aggressive and rare neuroblastoma for a year. He donned a Ninja Turtles mask to feel brave during radiotherapy. (Source: the Mail online | Health)
Source: the Mail online | Health - April 14, 2015 Category: Consumer Health News Source Type: news