Bespoke neuroblastoma therapy weaponizes cell metabolism
(Virginia Commonwealth University) Preclinical research from VCU Massey Cancer Center published recently in the Proceedings of the National Academy of Sciences shows that the combination of two existing drugs can exploit the metabolic " hunger " of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too much collateral damage to healthy tissue. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 30, 2021 Category: International Medicine & Public Health Source Type: news
World-first discovery paves way to new cancer treatment
(Children's Cancer Institute Australia) Australian researchers have discovered a new way to target, neuroblastoma. The discovery may also have important implications for other child and adult (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 25, 2021 Category: Cancer & Oncology Source Type: news
Natural " brake " against malignant neuroblastoma
(St. Anna Children's Cancer Research Institute) A factor that turns malignant tumors into benign ones? - That is exactly what scientists at St. Anna Children's Cancer Research Institute and colleagues have discovered. They studied tumors of the peripheral nervous system in children, namely neuroblastomas. The scientists discovered that the uncontrolled growth of benign neuroblastomas is stopped by a signal molecule produced by Schwann cells present within these tumors. This natural " brake " also works on malignant neuroblastoma cultures. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 12, 2021 Category: Cancer & Oncology Source Type: news
Natural 'brake' against malignant neuroblastoma
(St. Anna Children's Cancer Research Institute) A factor that turns malignant tumors into benign ones? - That is exactly what scientists at St. Anna Children's Cancer Research Institute and colleagues have discovered. They studied tumors of the peripheral nervous system in children, namely neuroblastomas. The scientists discovered that the uncontrolled growth of benign neuroblastomas is stopped by a signal molecule produced by Schwann cells present within these tumors. This natural " brake " also works on malignant neuroblastoma cultures. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 12, 2021 Category: Cancer & Oncology Source Type: news
Abundance of iron drives cell death and could inform novel treatments for neuroblastoma
(Virginia Commonwealth University) Anthony Faber, Ph.D., and a team of researchers at VCU Massey Cancer Center were awarded a grant from the American Cancer Society to study how the gene MYCN and an abundance of iron can drive cancer cell death in neuroblastoma and potentially be targeted with novel treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 23, 2021 Category: Cancer & Oncology Source Type: news
Researchers identify gene implicated in neuroblastoma, a childhood cancer
(Mayo Clinic) A new study by Mayo Clinic researchers has identified that a chromosome instability gene, USP24, is frequently missing in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The finding provides important insight into the development of this disease. The study is published in Cancer Research, the journal of the American Association for Cancer Research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 17, 2021 Category: Cancer & Oncology Source Type: news
Researchers identify gene implicated in neuroblastoma, a childhood cancer
ROCHESTER, Minn. ? A new study by Mayo Clinic researchers has identified that a chromosome instability gene,?USP24,?is frequently missing in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The finding provides important insight into the development of this disease. The study is published in Cancer Research, the journal of the American Association for [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 15, 2021 Category: Research Source Type: news
Stirring up conflicts in tumour cells
(University of W ΓΌ rzburg) With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumour neuroblastoma can be disrupted at a key point causing tumour cell death. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2021 Category: Cancer & Oncology Source Type: news
New drug targets for childhood cancer neuroblastoma identified
(Wellcome Trust Sanger Institute) The largest single cell study to date of the childhood cancer, neuroblastoma, has discovered that all neuroblastomas arise from a single type of embryonic cell called sympathoblasts. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 5, 2021 Category: Cancer & Oncology Source Type: news
How Do You Know if Your Child Has Neuroblastoma
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - January 27, 2021 Category: General Medicine Source Type: news
Creating a safe CAR T-Cell therapy to fight solid tumors in children
(Children's Hospital Los Angeles) Scientists modify CAR T-Cell therapy, making it more effective and less toxic, for possible use in solid tumors such as neuroblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 21, 2021 Category: Cancer & Oncology Source Type: news
Drug combination increases susceptibility to chemotherapy in cases of severe neuroblastoma
(University of Gothenburg) Researchers at the University of Gothenburg now suggest a possible cure for children with hard-to-treat forms of neuroblastoma using a new combination of drugs. In a new study in the journal Cancer Research, they describe how a two small molecule-based drug combination likely inhibit the tumor's growth. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: news
VRK1: a protein that reduces the survival of patients with neuroblastoma
(University of Seville) Researchers have characterised the function of VRK1 in neuroblastoma tumour cells and have determined that this protein is essential for tumour cell growth and proliferation. " By studying the expression of this protein in tumours, we were able to identify a priori patients where tumour progression is going to be worse, even in groups where current tools do not predict that behaviour, " notes Francisco M. Vega. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2020 Category: International Medicine & Public Health Source Type: news
Reductive stress in neuroblastoma cells aggregates protein and impairs neurogenesis
(University of Alabama at Birmingham) Cells require a balance among oxidation-reduction reactions, or redox homeostasis. Loss of that balance to create oxidative stress is often associated with neurodegeneration. Less is known about how loss of that balance at the other end of the spectrum -- reductive stress -- may affect neurons. Now researchers show for the first time that reductive stress promotes protein aggregation in neuroblastoma cells and impairs neurogenesis. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 8, 2020 Category: Biology Source Type: news
Monthly News Roundup - November 2020
Danyelza Gains Accelerated Approval to Treat Neuroblastoma
Neuroblastoma is a solid tumor of childhood that occurs in the nervous system outside of the brain. Some tumors are easily treatable, but the majority are aggressive in nature.
In... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 30, 2020 Category: Pharmaceuticals Source Type: news
