Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using mRNA to Generate Therapeutic Antibodies in the Brain
It may turn out to be cost-effective to replace delivery of therapeutic monoclonal antibodies with delivery of messenger RNA (mRNA), encapsulated in a lipid nanoparticle or linked to a cell penetrating molecule of some sort in order to reach the desired tissues and be taken up into the cytoplasm. Researchers here consider this in the context of treating Alzheimer's disease, where the primary thrust of therapeutic development involves the use of antibodies targeting the various protein aggregates thought to contribute to disease progression.
Monoclonal antibodies have emerged as a leading therapeutic agent for the ...
Source: Fight Aging! - April 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Soluble ADAM10 to Reduce Amyloid- β in the Brain
The research and development community continues to focus on amyloid-β as a primary target in Alzheimer's disease, despite the failure to produce meaningful benefits in patients in human clinical trials of immunotherapies targeting amyloid-β. It may yet prove to be the case that safer approaches than immunotherapies, used widely to reduce amyloid-β prior to the development of symptoms, could lower incidence of Alzheimer's disease. It seems evident that extracellular amyloid-β is not the right target in later stages of the condition, however.
Accumulation of amyloid β in the brain is regarded as a key initiato...
Source: Fight Aging! - June 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 25th 2019
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis.
Against Senolytics
https://www.fightaging.org/archives/2019/11/against-senolytics/
There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a...
Source: Fight Aging! - November 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Heat Shock Proteins as a Basis for Tackling Protein Aggregation in Neurodegenerative Diseases
Neurodegenerative conditions are largely characterized by the aggregation of a few altered proteins that are prone to forming solid deposits in and around neurons. Tissues, such as the brain, made up of long-lived cells, such as neurons, are particularly vulnerable to this sort of dysfunction, as they cannot dilute harmful protein aggregates by cell division, and dysfunctional cells are not readily destroyed and replaced. Cells must rely upon internal quality control mechanisms such as the presence of chaperone proteins responsible for chasing down misfolded or otherwise problematic proteins, and ensuring they are refolded...
Source: Fight Aging! - November 19, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Funtabulously Frivolous Friday Five 297
Dr Neil Long Funtabulously Frivolous Friday Five 297
It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 297 (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - October 11, 2019 Category: Emergency Medicine Authors: Dr Neil Long Tags: FFFF Alexander the great Archilochus black eye drugs facial trauma Leprosy metastatic neuroblastomas panda eyes portugal Raccoon eyes sink to the level of training William Henry Battle Source Type: blogs
New Fluorescent Tags Developed to Track Cause of Alzheimer ’s
Amyloid protein plaques, particularly ones made of beta-amyloid 42, are a prime suspect in the development of Alzheimer’s disease. Soluble oligomers, in this case molecules with a few repeating peptide units, may turn out to be the main culprit. They’re known to be toxic to neurons and some recent studies have led researchers to focus more attention on them.
To better understand the root causes of Alzheimer’s, researchers need a way to track oligomers in the lab, but Thioflavin T dyes that lab techs use to flag amyloid fibrils don’t work well with oligomers. To overcome this serious limitation, c...
Source: Medgadget - September 26, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Neurology Source Type: blogs
Neuroblastoma with Sutural Metastases: Case Discussion
Presenting a case of neuroblastoma with sutural metastases. DAMS unplugged is YouTube series by DAMS team presenting clinical and integrated videosFamous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - September 3, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Maintenance Mechanisms Struggle to Break Down TDP-43 Aggregates, Leading to Neurodegeneration
The most common age-related neurodegenerative conditions are associated with the build up of various protein aggregates, chemically altered or misfolded proteins that can form solid deposits in and around cells when in that state. These protein aggregates are characterized by the ability to spread and grow, acting as seeds for more aggregation. They include the well known amyloid-β and tau of Alzheimer's disease, the α-synuclein associated with Parkinson's disease, and so forth. In recent years researchers have been devoting ever more effort to investigations of a less well known protein aggregate, TDP-43, associated wit...
Source: Fight Aging! - August 16, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 29th 2019
In this study, we report the age-associated differences between fetal MSC (fMSC) populations and MSCs isolated from elderly donors with respect to their transcriptomes. We successfully reprogrammed fMSCs (55 days post conception) and adult MSC (aMSC; 60-74 years) to iPSCs and, subsequently, generated the corresponding iMSCs. In addition, iMSCs were also derived from ESCs. The iMSCs were similar although not identical to primary MSCs. We unraveled a putative rejuvenation and aging gene expression signature. We show that iMSCs irrespective of donor age and cell type re-acquired a similar secretome to that of their parent...
Source: Fight Aging! - April 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tackling Amyloid- β Oligomers by Interfering in Specific Interactions Necessary to Protein Aggregation
The present consensus on the the development of Alzheimer's disease is that it starts with the accumulation of amyloid-β, though there are many competing theories as to why only some people exhibit this problem to a great enough degree to produce pathology. The biochemistry of oligomers supporting amyloid-β causes sufficient disarray in brain metabolism to set the stage for neuroinflammation, malfunction of immune cells in the brain, and aggregation of altered forms of tau protein into neurofibrillary tangles that cause most of the damage and cell death in the later stages of the condition. The failure to improve outcome...
Source: Fight Aging! - April 25, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Orbital Neuroblastoma Metastases : DAMS Medicine Unplugged
DAMS Medicine Unplugged is an initiative of DAMS, Leading Medical education academy in India, helping students integrate various aspects of a disease. This is an integrated approach to case of orbital neuroblastoma metastases.Famous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 22, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Eponymythology: Atraumatic Abdominal Ecchymosis
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Overview
We review the original descriptions of 5 eponymous signs (n=6) associated with non-traumatic abdominal ecchymosis.
These commonly cited eponyms involving the abdominal wall and flanks (Grey Turner, Cullen and Stabler); scrotum (Bryant) and upper thigh (Fox) may be useful clues directing the examiner to consider potentially serious causes of abdominal pathology.
Cullen sign
Thomas Stephen Cullen (1869–1953) was a Canadian gynecologist
Non-traumatic peri-um...
Source: Life in the Fast Lane - April 18, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Eponymythology Abdominal Ecchymosis Bryant sign Cullen sign fox sign Francis Edward Stabler George Grey Turner Grey Turner sign John Adrian Fox John Henry Bryant Stabler sign Thomas Stephen Cullen Source Type: blogs
