Heat Shock Proteins as a Basis for Tackling Protein Aggregation in Neurodegenerative Diseases
Neurodegenerative conditions are largely characterized by the aggregation of a few altered proteins that are prone to forming solid deposits in and around neurons. Tissues, such as the brain, made up of long-lived cells, such as neurons, are particularly vulnerable to this sort of dysfunction, as they cannot dilute harmful protein aggregates by cell division, and dysfunctional cells are not readily destroyed and replaced. Cells must rely upon internal quality control mechanisms such as the presence of chaperone proteins responsible for chasing down misfolded or otherwise problematic proteins, and ensuring they are refolded...
Source: Fight Aging! - November 19, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Funtabulously Frivolous Friday Five 297
Dr Neil Long Funtabulously Frivolous Friday Five 297 It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 297 (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - October 11, 2019 Category: Emergency Medicine Authors: Dr Neil Long Tags: FFFF Alexander the great Archilochus black eye drugs facial trauma Leprosy metastatic neuroblastomas panda eyes portugal Raccoon eyes sink to the level of training William Henry Battle Source Type: blogs

New Fluorescent Tags Developed to Track Cause of Alzheimer ’s
Amyloid protein plaques, particularly ones made of beta-amyloid 42, are a prime suspect in the development of Alzheimer’s disease. Soluble oligomers, in this case molecules with a few repeating peptide units, may turn out to be the main culprit. They’re known to be toxic to neurons and some recent studies have led researchers to focus more attention on them. To better understand the root causes of Alzheimer’s, researchers need a way to track oligomers in the lab, but Thioflavin T dyes that lab techs use to flag amyloid fibrils don’t work well with oligomers. To overcome this serious limitation, c...
Source: Medgadget - September 26, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Neurology Source Type: blogs

Neuroblastoma with Sutural Metastases: Case Discussion
Presenting a case of neuroblastoma with sutural metastases. DAMS unplugged is YouTube series by DAMS team presenting clinical and integrated videosFamous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - September 4, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cellular Maintenance Mechanisms Struggle to Break Down TDP-43 Aggregates, Leading to Neurodegeneration
The most common age-related neurodegenerative conditions are associated with the build up of various protein aggregates, chemically altered or misfolded proteins that can form solid deposits in and around cells when in that state. These protein aggregates are characterized by the ability to spread and grow, acting as seeds for more aggregation. They include the well known amyloid-β and tau of Alzheimer's disease, the α-synuclein associated with Parkinson's disease, and so forth. In recent years researchers have been devoting ever more effort to investigations of a less well known protein aggregate, TDP-43, assoc...
Source: Fight Aging! - August 16, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, April 29th 2019
In this study, we report the age-associated differences between fetal MSC (fMSC) populations and MSCs isolated from elderly donors with respect to their transcriptomes. We successfully reprogrammed fMSCs (55 days post conception) and adult MSC (aMSC; 60-74 years) to iPSCs and, subsequently, generated the corresponding iMSCs. In addition, iMSCs were also derived from ESCs. The iMSCs were similar although not identical to primary MSCs. We unraveled a putative rejuvenation and aging gene expression signature. We show that iMSCs irrespective of donor age and cell type re-acquired a similar secretome to that of th...
Source: Fight Aging! - April 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Tackling Amyloid- β Oligomers by Interfering in Specific Interactions Necessary to Protein Aggregation
The present consensus on the the development of Alzheimer's disease is that it starts with the accumulation of amyloid-β, though there are many competing theories as to why only some people exhibit this problem to a great enough degree to produce pathology. The biochemistry of oligomers supporting amyloid-β causes sufficient disarray in brain metabolism to set the stage for neuroinflammation, malfunction of immune cells in the brain, and aggregation of altered forms of tau protein into neurofibrillary tangles that cause most of the damage and cell death in the later stages of the condition. The failure to improve...
Source: Fight Aging! - April 25, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Orbital Neuroblastoma Metastases : DAMS Medicine Unplugged
DAMS Medicine Unplugged is an initiative of DAMS, Leading Medical education academy in India, helping students integrate various aspects of a disease. This is an integrated approach to case of orbital neuroblastoma metastases.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 22, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Eponymythology: Atraumatic Abdominal Ecchymosis
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Overview We review the original descriptions of 5 eponymous signs (n=6) associated with non-traumatic abdominal ecchymosis. These commonly cited eponyms involving the abdominal wall and flanks (Grey Turner, Cullen and Stabler); scrotum (Bryant) and upper thigh (Fox) may be useful clues directing the examiner to consider potentially serious causes of abdominal pathology. Cullen sign Thomas Stephen Cullen (1869–1953) was a Canadian gynecologist Non-traumat...
Source: Life in the Fast Lane - April 18, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Eponymythology Abdominal Ecchymosis Bryant sign Cullen sign fox sign Francis Edward Stabler George Grey Turner Grey Turner sign John Adrian Fox John Henry Bryant Stabler sign Thomas Stephen Cullen Source Type: blogs

Funtabulously Frivolous Friday Five 234
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 234. Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL Question 1: What is Stabler sign? + Reveal the Funtabulous Answer expand(document.getElementById('ddet1709146611'));expand(document.getElementById('ddetlink1709146611')) Stabler...
Source: Life in the Fast Lane - April 12, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five appendicitis botulism cullen echinococcus granulosus ectopic pregnancy Francois Henri Hallopeau hair hydatid Kenya Rovsing's Selman Waksman Stabler's sign Trichotillomania trichotillomaniac water lily si Source Type: blogs

Amyloid- β May Cause Mitochondrial Dysfunction in Alzheimer's Disease
This study reinforces the toxicity of oligomeric amyloid-β on neuronal mitochondria and stresses the importance for protective compounds to protect the mitochondria from oligomeric amyloid-β toxicity." In the new study, cells known as pyramidal neurons, extracted from the hippocampus of patients who died of Alzheimer's, display a marked reduction in the expression of a suite of mitochondrial genes, pointing to their degradation by OAβ. The reduction of mitochondrial gene expression was also seen when cells belonging to a human neuroblastoma cell line were exposed to OAβ. The authors stress t...
Source: Fight Aging! - January 24, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Neuroblastoma : RadioPath Integrated Video
Presenting an integrated video on neuroblastoma and its typical radiological and pathological features.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - September 21, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Orphan Diseases Or Population Health? Policy Choices Drive Venture Capital Investments
The US exhibits a remarkable pipeline of biopharmaceutical innovation, with 170 new drugs and biologics launched into the market between 2011 and 2015 and another 22 drugs approved in 2016. A striking feature of the pharmaceutical pipeline is the large percentage launched for the treatment of small “orphan” indications, defined by the Food and Drug Administration (FDA) as including fewer than, often many fewer than, 200,000 patients in the United States. Almost half (74) of the products approved by the FDA between 2011 and 2015 were for orphan indications, twice the number (36) approved during the same period b...
Source: Health Affairs Blog - July 21, 2017 Category: Health Management Authors: Dayton Misfeldt and James C. Robinson Tags: Costs and Spending Drugs and Medical Innovation Orphan Drug Act orphan drugs venture capitalism Source Type: blogs

A Demonstration in Mice of Whole Mitochondria Delivered as a Therapy
Mitochondria, the swarming power plants of the cell, become damaged and dysfunctional with age. Can this be addressed by delivering complete, whole, new mitochondria as a therapy? There have been signs in past years that cells can ingest and incorporate mitochondria from the surrounding environment, but few useful demonstrations to show whether or not this is common in living tissues. In the research here, researchers achieve that result, delivering mitochondria into tissues as a therapy, and using this approach to treat an animal model of Parkinson's disease. This neurodegenerative condition is associated with degraded mi...
Source: Fight Aging! - March 7, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

MR-HIFU and ThermoDox to Treat Recurrent Childhood Tumors: Interview with AeRang Kim, Principal Investigator
Children’s National Health System and the Celsion Corporation (Lawrenceville, NJ) have recently announced a Phase I clinical trial in the US to determine a safe and tolerable dose of ThermoDox in conjunction with non-invasive magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU). The trial is aimed on young adults and children with recurring solid tumors. ThermoDox technology consists of liposomes loaded with doxorubicin, a conventional chemotherapeutic drug. Liposomes are small lipid structures which can be used to encapsulate and deliver drugs through the bloodstream. While liposomal doxor...
Source: Medgadget - December 6, 2016 Category: Medical Equipment Authors: Conn Hastings Tags: Exclusive Nanomedicine Oncology Source Type: blogs

Are Priority Review Vouchers The Answer To Incentivize Drug Development? Not So Fast.
In the May issue of Health Affairs, two papers examine the potential for voucher systems to incentivize drug development in areas of unmet medical need. Co-authors Kevin Outterson and Anthony McDonnell take a look at potential exclusivity voucher programs designed to encourage development of new antibiotics, while David Ridley and Stephane Régnier analyze the effects that expansion of existing priority review voucher (PRV) programs may have on the value of PRVs as a development incentive. Ridley and Régnier’s work is of particular importance as both houses of Congress pursue a spate of legislative propo...
Source: Health Affairs Blog - June 15, 2016 Category: Health Management Authors: Pranav Aurora, Morgan Romine and Gregory Daniel Tags: Costs and Spending Drugs and Medical Technology Featured Global Health Health Professionals Quality FDA FDAAA priority review rare diseases Source Type: blogs

A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases. The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan&...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs

Pediatric palliative care: We must do more
How is it that, in this day and age, a talented teenager treated for lymphoma emerges cured but with a life-threatening eating disorder? How is it that, in our nation’s capital, a boy dying at home from neuroblastoma experiences excruciating pain in his final moments? How is that, when we develop new drugs to treat children with cancer, we do not, at the same time, routinely and in a standardized manner ask them how they are feeling? As a pediatric oncologist and palliative care physician, I was alarmed by stories like these at the recent Institute of Medicine Workshop on Comprehensive Care f...
Source: Kevin, M.D. - Medical Weblog - July 14, 2015 Category: Journals (General) Authors: Tags: Physician Palliative care Pediatrics Source Type: blogs

The Future of Cord Blood Research
  You may have heard that the stem cells in your baby’s umbilical-cord blood can save lives, but if you’re like most people, you have only a vague notion of how stem cells work — or which diseases they can treat. Right now, certain cancers, blood disorders, and immune disorders, among other conditions, are being successfully treated with cord-blood stem cells — and thanks to cord blood research, the list of conditions and diseases that may be treated by these stem cells is growing. Why is it important to know about the cord blood research and what types of diseases it can treat? Knowing what co...
Source: Cord Blood News - December 15, 2014 Category: Perinatology & Neonatology Authors: joyce at mazelabs.com Tags: babies blood disorder brain development Cord Blood medical research parents pregnancy stem cells affordable cord blood banking bone marrow breast feeding cerebral palsy cord blood banking fees cord blood banking information cor Source Type: blogs

Are There Limits of 3D Printing in Healthcare?
In only a few days’ time, one could read about the potentials of 3D printing in healthcare from different angles. Surgeons in Portugal recreated the tumor and surrounding tissue of a 5-year-old boy’s neuroblastoma using 3D-printing to be able to practice removing the tumor before trying again after failed attempts. In another story, a company tries to create a specialized filament and process for the 3D printing of medical pill capsules. More and more ideas appear online every day about how this technology could be used for medical purposes. Companies such as 3DSystems are in the forefront o...
Source: ScienceRoll - August 19, 2014 Category: Geneticists and Genetics Commentators Authors: Bertalan Meskó (MD, PhD) Tags: 3D Printing Future Healthcare Medicine Source Type: blogs

Talia Joy: The Beauty Blogger We're Already Missing
UPDATE: We regret to inform you that Talia Joy passed away today after her five-year battle with cancer. The intrepid 13-year-old, who not only vlogged her way to fame but also garnered herself a Cover Girl ad, is a true inspiration to everyone here at SELF. Check out what our blogger, Alex Samuel, said about Talia back in September 2012. Have you guys ever heard of Talia Joy? For those of you the haven't, it may be time to switch to waterproof mascara. Here's the deal: not only is Talia a bubbly, brilliant twelve-year-old makeup genius with over 14 million views on YouTube, she's been battling cancer (neuroblastoma and ...
Source: The ND Blog: Notes from the Nutritionista by Monica Reinagel, L.D.N., C.N.S. - July 16, 2013 Category: Nutritionists and Food Scientists Tags: Beauty beauty news beauty tips Source Type: blogs

USMLE Questions – Characteristic Disease Findings
The United States Medical Licensing Examination (USMLE) is designed to emphasize knowledge of clinical scenarios and clinical pearls, even on Step I. Listed below are some commonly encountered disease findings and characteristics. Feature Disease 45, X chromosome Turner’s syndrome 5-HIAA increased in urine Carcinoid syndrome Aganglionic rectum Hirschsrpung’s disease Apple-core sign on barium enema Colon cancer Arched back (opisthotonos) Tetanus Argyll-Robertson pupil Syphilis Ash leaf on forehead Tuberous sclerosis Auer rods  Acute myelogenous leukemia Austin Flint murmur Aortic r...
Source: Inside Surgery - January 18, 2013 Category: Surgeons Authors: Editor Tags: Surgpedia USMLE diseases findings VMA water hammer pulse Source Type: blogs

Minimal Reporting Guidelines for the Treatment of Cancer Patients
Minimal Reporting Guidelines for the Treatment of Cancer Patients As laboratory physicians, our contribution to patient care is knowledge:  this is the starting point from which all informed therapeutic intervention proceeds.  How that knowledge is obtained and communicated is the art and science of our profession.  These minimal diagnostic guidelines are designed to be used as an aid, not a constraint, in that process.  The guidelines are presented in a specific format out of necessity, but any format that effectively communicates the necessary information in a given patho...
Source: Oncopathology - September 5, 2011 Category: Cancer & Oncology Source Type: blogs