What Causes Flushing?
Discussion
Flushing is usually thought of as a benign condition such as blushing, but can be quite irritating if it is frequent or persistent (i.e. menopausal hot flashes) or even pathologic (i.e. malignancy). “Flushing is a subjective and sensation of warmth that is accompanied by reddening of the skin anywhere on the body but favors the face, neck, and upper torso…. Flushing can be broadly divided into episodic or persistent. Episodic flashing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing result in a fixed facial erythema with telangiectasias and cyano...
Source: PediatricEducation.org - April 30, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Removing the enablers: Reducing number of tumor-supporting cells to fight neuroblastoma
(Children's Hospital Los Angeles) Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages -- a type of immune cell -- can negatively affect the response to chemotherapy against neuroblastoma. Their findings suggest that combination therapy might be effective in patients with high-risk disease, even those who have limited anti-tumor T cell responses. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 23, 2018 Category: Cancer & Oncology Source Type: news
New biomarkers for neuroblastoma, a type of cancer in children
(University of Gothenburg) Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 19, 2018 Category: Cancer & Oncology Source Type: news
Inspiring battle of siblings both diagnosed with cancer
Two of Emily Neumann's children battled cancer. Her son Rowan, seven, was diagnosed with Leukemia and her daughter Winnie, one, was diagnosed with neuroblastoma. (Source: the Mail online | Health)
Source: the Mail online | Health - March 5, 2018 Category: Consumer Health News Source Type: news
Wakefield woman's two sons are diagnosed with cancer
Keri Redfearn, 32, from Wakefield, thought she was living her worst nightmare when her 10-year-old son Leo was diagnosed with neuroblastoma in October last year. (Source: the Mail online | Health)
Source: the Mail online | Health - February 26, 2018 Category: Consumer Health News Source Type: news
Estrogen causes neuroblastoma cells to mature into neurons
(Karolinska Institutet) The female sex hormone estrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children. In laboratory experiments, researchers at Karolinska Institutet in Sweden demonstrate that estrogen treatment and overexpression of the estrogen receptor cause malignant neuroblastoma cells to mature into neuron-like cells. The study, which is published in PNAS, gives hope of new treatment possibilities. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 29, 2018 Category: Cancer & Oncology Source Type: news
'Hijacker' drives cancer in some patients with high-risk neuroblastoma
(St. Jude Children's Research Hospital) Researchers in Memphis and Boston have collaborated to show c-MYC is an oncogene that drives neuroblastoma in some high-risk patients; the findings help set the stage for much-needed precision medicines (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 22, 2018 Category: Biology Source Type: news
Uncovering molecular targets for childhood cancer therapeutics
(Tokyo Medical and Dental University) Neuroblastoma (NB) is the most common solid tumor found in children and is associated with poor prognosis; however, little is known regarding the molecular targets located in the long arm of chromosome 11 (11q). Tokyo Medical and Dental University (TMDU)-centered researchers revealed the loss or imbalance of genes ATM, MRE11A, H2AFX, and/or CHEK1 in 11q in 20.7% of NBs. Furthermore, they found 83.3% NB-derived cell lines exhibited sensitivity to PARP inhibitors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 28, 2017 Category: Cancer & Oncology Source Type: news
Structural basis of membrane disruption and cellular toxicity by {alpha}-synuclein oligomers
Oligomeric species populated during the aggregation process of α-synuclein have been linked to neuronal impairment in Parkinson’s disease and related neurodegenerative disorders. By using solution and solid-state nuclear magnetic resonance techniques in conjunction with other structural methods, we identified the fundamental characteristics that enable toxic α-synuclein oligomers to perturb biological membranes and disrupt cellular function; these include a highly lipophilic element that promotes strong membrane interactions and a structured region that inserts into lipid bilayers and disrupts their integ...
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Fusco, G., Chen, S. W., Williamson, P. T. F., Cascella, R., Perni, M., Jarvis, J. A., Cecchi, C., Vendruscolo, M., Chiti, F., Cremades, N., Ying, L., Dobson, C. M., De Simone, A. Tags: Biochemistry, Neuroscience reports Source Type: news
MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas
Activation of the RAS-RAF-MEK-ERK signaling pathway is implicated in driving the initiation and progression of multiple cancers. Several inhibitors targeting the RAS-MAPK pathway are clinically approved as single- or polyagent therapies for patients with specific types of cancer. One example is the MEK inhibitor trametinib, which is included as a rational polytherapy strategy for treating EML4-ALK–positive, EGFR-activated, or KRAS-mutant lung cancers and neuroblastomas that also contain activating mutations in the RAS-MAPK pathway. In addition, in neuroblastoma, a heterogeneous disease, relapse cases display an incre...
Source: Signal Transduction Knowledge Environment - November 28, 2017 Category: Science Authors: Umapathy, G., Guan, J., Gustafsson, D. E., Javanmardi, N., Cervantes-Madrid, D., Djos, A., Martinsson, T., Palmer, R. H., Hallberg, B. Tags: STKE Research Articles Source Type: news
Thousands of strangers gave a sick 9-year-old an early Christmas. He died days after celebrating.
Jacob Thompson spent nearly half of his short life battling cancer. The 9-year-old boy, who loved penguins, died Sunday, four years after he was diagnosed with Stage 4 neuroblastoma, a rare cancer that affects mostly young children. As his family had expected, Thompson didn’t live long enough to celebrate Christmas, a holiday he loves. But before his death, […]Related:Risk of stillbirth is double in pregnant women who sleep on their backs, study findsA dying vet needed CPR. Hidden video shows his nurse laughing instead.The truth behind the ‘first marijuana overdose death’ headlines (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - November 21, 2017 Category: Consumer Health News Source Type: news
Boy with cancer dies after wish for early Christmas
Jacob Thompson battled neuroblastoma for four years, and people around the world pitched in to bring him joy in his final days (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 20, 2017 Category: Consumer Health News Source Type: news
Thousands of strangers gave a sick child an early Christmas. Days before Thanksgiving, he died.
Jacob Thompson spent nearly half of his short life battling cancer. The 9-year-old boy, who loved penguins, died Sunday, four years after he was diagnosed with Stage 4 neuroblastoma, a rare cancer that affects mostly young children. As his family had expected, Thompson didn’t live long enough for Christmas, a holiday he loves. But shortly before his death, […]Related:Risk of stillbirth is double in pregnant women who sleep on their backs, study findsA dying vet needed CPR. Hidden video shows his nurse laughing instead.The truth behind the ‘first marijuana overdose death’ headlines (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - November 20, 2017 Category: Consumer Health News Source Type: news
CHLA is awarded more than $1 million from St. Baldrick's Foundation to fund cancer research
(Children's Hospital Los Angeles) Three physician-researchers with the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles (CHLA) have been awarded more than $1 million in grants from the St. Baldrick's Foundation, the largest private funder of childhood cancer research. The funding will be used to support research efforts spanning both neuroblastoma and acute lymphoblastic leukemia -- two of the most aggressive childhood cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 14, 2017 Category: Cancer & Oncology Source Type: news
CHLA is awarded more than $1M from St. Baldrick's Foundation to fund cancer research
(Children's Hospital Los Angeles) Three physician-researchers with the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles (CHLA) have been awarded more than $1 million in grants from the St. Baldrick's Foundation, the largest private funder of childhood cancer research. The funding will be used to support research efforts spanning both neuroblastoma and acute lymphoblastic leukemia -- two of the most aggressive childhood cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 14, 2017 Category: Cancer & Oncology Source Type: news
