New Neuronal Markers
Check Them Out!We continue to addnew antibodies. Many are additions to our frequently used and widely publishedNeuron-Glial Markers.Image: Immunofluorescent analysis of cortical neuron-glial cell culture from E20 rat stained with mouse mAb to GAP43, MO22170, dilution 1:1,000, in red, and costained with chicken pAb to MAP2, dilution 1:10,000, in green. The blue is DAPI staining of nuclear DNA. GAP43 antibody labels protein expressed in the axonal membrane of the neuronal cells, while the MAP2 antibody stains dendrites and perikarya of neurons. Name Species Applications Aurora A/B Kinase Human, Mouse, Rat ICC, WB, IHC, IF Au...
Source: Neuromics - August 7, 2018 Category: Neuroscience Tags: DJ1 Antibody GAP43 Antibody Ki67 antibody. Vimentin Antibody nestin antibody OPA1 Antibody Tuj 1 antibody Source Type: news

Easy Immunostaining Staining
10X the Signal at a Fraction of the CostTime is money. This is especially true of routine immunostaining assays.We are pleased to introduce you toEZ-HRPTM Polymer Detection. Features include:10-15 times more sensitive than conventional avidin-biotin detection Allows for entire staining procedure to be completed in just under 2 hours Requires less primary antibody (3-4 times less) Does not produce non-specific background staining Can be used on unfixed or chemical fixed (formalin, formaldehyde, alcohol, etc), paraffin-embedded and frozen tissue sections.Comparison of IHC images using EZ-HRP ™ Polymer vs. a c...
Source: Neuromics - July 31, 2018 Category: Neuroscience Tags: HRP-Staining. Immunofluorescence Immunonostaining Source Type: news

Our Hearing Adapts in Space
This study uses ourShank 1a Antibody to determine changes in the neuronal structure of the ear in microgravity.Image: Verification of antibodies to CtBP2 and Shank1a. A and B: serial 14- µm cryosections were obtained from a postnatal day 71 (P71) mouse utricle, and maximum-intensity projections are shown. Hair cell (hc) and support cell (sc) nuclei are illuminated by the DAPI stain (blue). Numerous closely associated CtBP2-and Shank1a-positive puncta can be observed in the positive immunostained section represented in A (block arrowheads). The CtBP2-positive puncta highlighted by the flared arrowhead in A m...
Source: Neuromics - July 24, 2018 Category: Neuroscience Tags: hair cells microgravity Shank 1a antibody Source Type: news

Staining Cells and Tissue
The background is Bad!Yes, it is. It compromises data. We have a solution.FluoMuteTMFluoMute ™ ready-to-use reagent to reduce autofluorescence in cells and tissue. Just incubate fixed cells of tissue sections with FluoMute™ for 30-60 min at room temperature, rinse with PBS and continue with immunofluorescence ICC or/and IHC protocols. Treatment with FluoMute™ does not affect cell morp hology and the integrity of tissue antigens to be detected with primary antibodies (see bottom image). FluoMute™ is compatible with paraffin-embedded and frozen tissue sections, stem cells, lymphocytes and mammalian ce...
Source: Neuromics - July 19, 2018 Category: Neuroscience Tags: autofluorescence FluoMute Source Type: news

Human Cells in Action
Human Microvascular Retinal Endothelial Cells (HMRECS)We have built the foundation ofNeuromics on satisfied customers. We make a practice of following up with each user to make sure our solutions are working as expected. If not, we offer " no question asked " refunds or replacements.This is especially important for ourhuman cells,media, and supplements. Success with these is easy to measure as either the cells are healthy and happy or they are not.We also usereviews andpublications as another measure of satisfaction. Here I would l highlight the latest publication using ourHREMCS. A. P. Da Cunha, Q. Zha...
Source: Neuromics - July 11, 2018 Category: Neuroscience Tags: Culturing Media endothelial cells FBS Fetal Bovine Serum HRMECS Human Endothelial Cells Source Type: news

Neuromics' Fetal Bovine Serum (FBS) Strikes Again
Potent FBS at Pricing You'll LikeNeuromics started providingFBS to researchers in early 2017. Our goal was to provide thorough tested and 9-CFR compliant FBS with the lowest pricing anywhere.In order to ensure our initial claims are trustworthy, we follow up with all our users and ask that they providefeedback. Here's the latest review-Ordered Fetal bovine serum. Best price and quality" - Juwen D, Albert Einstein College of Medicine. Product: Heat-inactivated FBS, cat no. FBS001-HI.We are now starting to see the use of our FBS reference in publications: Am élie Robert, Peirun Tian, Stephen A. Ada...
Source: Neuromics - July 2, 2018 Category: Neuroscience Tags: 3-D Cell based Assays cell biology Cell Cultures FBS Fetal Bovine Serum Source Type: news

You'll Love our FBS!
Check out Testimonials from UsersNeuromics is proud to offer you the high-quality Fetal Bovine Serum, the same serum we use internally, without the high cost. Our customers, researchers like you, agree.Ordered Fetal bovine serum. Best price and quality" - Juwen D, Albert Einstein College of Medicine. Product: Heat-inactivated FBS, cat no. FBS001-HIOutstanding service. Fetal bovine serum was of highest quality, easy to order and packaging and shipping were best possible. " - Rosemary, University of Buffalo Product: Heat-inactivated FBS, cat no. FBS001-HI (see all of Neuromics reviews&...
Source: Neuromics - June 28, 2018 Category: Neuroscience Tags: FBS Fetal Bovine Serum Source Type: news

Autophagy Assay Kits
Detects Autophagy in Living CellsAutophagy is a conserved lysosomal recycling process by which cells break down their own components such as proteins, lipids, and carbohydrates. The process plays an important role in maintaining homeostasis and destroying intracellular pathogens. In addition, autophagy can be upregulated in times of starvation or stress to provide additional nutrients for the cell. Dysregulation of autophagy has implications for cancer, infection, and degenerative diseases.Autophagy is a three-stage process. First, cytoplasmic components targeted for degradation are sequestered, resulting in the formation ...
Source: Neuromics - June 26, 2018 Category: Neuroscience Tags: Apoptosis Detection Apoptosis Visualization autophagy autophagy detection Cytotoxicity Assays necrosis Source Type: news

Markers for Tyrosine Hydroxylase-TH
Proven and PublishedTyrosine hydroxylase TH is a necessary enzyme to create neurotransmitters and protect the body against oxidative stress.Dysregulation of this enzyme results in manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.Markers to TH are important for studying its role in neurotransmission and how it is altered in disorders and diseases.We have many options and this enables you to choose the best markers for your research. All are proven andpublished.TH staining of mouse salivary gland tissue. https://d...
Source: Neuromics - June 14, 2018 Category: Neuroscience Tags: neuroscience TH antibody Tyrosine Hydroxlase antibody Source Type: news

Put our Antibodies to Work for You!
Tested and Characterized for Results You Can TrustWhen you select a vendor forantibodies, there is a measure of trust. We know you are asking, " will it work in the applications as advertised " .Since the inception of Neuromics, our guiding principle is providing well-characterized solutions for results you can trust and understand. In order to provide as much comfort in the purchase of our solutions, we encourage access topublications,data, andtestimonials.Here're some recent testimonials:Good antibody! Product Name: Tuj 1, Chicken – (Cat# CH23005) Good for neuronal staining. Bright and specific.Liang Shi ...
Source: Neuromics - June 6, 2018 Category: Neuroscience Tags: Antibodies Antibody TRPV1 antibodies TRPV1 antibody Source Type: news

New Fibrillarin Antibody
Potent Nucleoli MarkerGiven the importance ofNucleus and Related Markers to all branches of cell/molecular biology, we are dedicated to having the best.We have just added a newFibrillarin Antibody.Images: Immunofluorescent analysis of (A) C6 rat glioma cells and (B) Human embryonic kidney cells stained with mouse mAb to fibrillarin, MO22169, dilution 1:1,000 in red, in both cases costained with chicken pAb to vimentin, CPCA-Vim, dilution 1:10,000 in green. The blue is DAPI staining of nuclear DNA.Nop1p/Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646)....
Source: Neuromics - June 4, 2018 Category: Neuroscience Tags: Fibrillarin Antibody Nuclear Staining Nucleoli Source Type: news

New 3-D Eye Model
Morein-vivo like ModelWe see our world in 3-D. Diseases of the eye compromise this ability.Neuromics'is pleased to announce that we have a3-D model aimed at accelerating drug discovery for these diseases. Sight is a terrible thing to lose and the faster new drugs can be discovered, fewer people will have to suffer the loss of sight.Our 3D Human Retinal Microvascular Angiogenesis model is constructed using GFP ‐Tagged human Retinal Microvascular Endothelial cells. They are co-cultured with RFP-Tagged human supporting cells. GFP positive human retinal capillary-like tubule formation can be monitored in real time under fluo...
Source: Neuromics - May 30, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D Cell Culturing 3-D Retinal Organoids Diabetic retinopathy Human Retinal Microvascular Endothelial Cells Source Type: news

Antibodies Against Neuropeptides
Another Nod From Nature Scientific ReportsPublications referencing use of our antibodies continue to build. We are recognized for having potentNeuropeptide Antibodies.This most recent publication references ourGuinea Pig Substance-P Antibody: Khaled Abdallah, Francis Nadeau, Francis Bergeron, Sylvie Blouin, V éronique Blais, Kelly M. Bradbury, Christine L. Lavoie, Jean-Luc Parent;, Louis Gendron. (2018). Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents. Scientific Reports volume 8, Article number: 7321 (2018) doi:10.1038/s41598-018-25626-yFigure: Distribution of the Cre-GFP in t...
Source: Neuromics - May 20, 2018 Category: Neuroscience Tags: Neuropeptide Antibodies Neuropeptides Substance P Antibodies Substance P Antibody Source Type: news

Researchers Love our FBS
Potent Serum at a Great Price!We are pleased by the 5-star ratings on ourFetal Bovine Serum(FBS). Check them out.Outstanding service. Fetal bovine serum was of highest quality, easy to order and packaging and shipping were best possible.Rosemary Dziak - May 08, 2018 - Rating: 5.0This is first time to buy FBS from them. Rose is very nice person. they make you easy and comfortable to purchase.jie wei - Feb 16, 2018 - Rating: 5.0I enjoyed working with the people at Neuromics. The sale person was very friend and willing to take extra time to solve our problems. Product Name: FBS - (Cat#FBS001) ...
Source: Neuromics - May 10, 2018 Category: Neuroscience Tags: 3-D Cell based Assays Cell Based Assays. FBS Fetal Bovine Serum Source Type: news

Fibroblast Compression and Tumor Cells Migration
Role of Compression in MetastasisOurHuman Pancreatic Fibroblasts play a key role in this study.Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated fibroblasts can acquire an activated phenotype and produce excessive amounts of extracellu lar matrix creating a highly dense stroma, a situation known as desmoplasia. Maria Kalli, Panagiotis Papageorgis, Vasiliki Gkretsi, Triantafyllos Stylianopoulos. (2018).Solid Stress Facilitates Fibroblasts Activation to Pro...
Source: Neuromics - May 1, 2018 Category: Neuroscience Tags: Cancer Associated Fibroblasts Desmoplasia Human Pancreatic Fibroblasts metastasis Source Type: news

Pure and Potent Human Primary Retinal Pigment Endothelial Cells (HRPES)
Culture ReadyNeuromics is a recognized leader in providing researchers 21-CFR CompliantPrimary Human Cells.Here we feature our newRetinal Pigment Epithelial Cell (HRPES). These hard to find cells are reasonably priced and culture ready,HRPES in CultureCells are provided at passage 3. HRPEs growth medium (contains 10% serum and growth supplements, Alpha-33) is recommended for cell culture and these cells have a minimum average population doubling capacity of 8 when cultured following the detailedprotocol. (Source: Neuromics)
Source: Neuromics - April 26, 2018 Category: Neuroscience Tags: cell culturing protocol culturing human retinal pigment epithelial cells Source Type: news

ATP and Pain
P2XRs Play a Key RoleIn dorsal root ganglion (DRG) neurons, ATP is an important neurotransmitter in nociceptive signaling through P2 receptors (P2Rs) such as P2X2/3R, and adenosine is also involved in anti-nociceptive signaling through adenosine A1R.ENNPs interact with P2XRs to metabolize ATP to AMP in DRGs. Kentaro Nishida, Yuka Nomura, Kanako Kawamori, Akihiro Ohishi, Kazuki Nagasawa.ATP metabolizing enzymes ENPP1, 2 and 3 are localized in sensory neurons of rat dorsal root ganglion. European Journal of Histochemistry 2018; 62:2877.Images: Rat DRG stained withNeuromics P2X2Rand ENPP1.Modulating ATP Processing in DRG...
Source: Neuromics - April 19, 2018 Category: Neuroscience Source Type: news

Long Term Culturing of Cells
Non-Perfusion ModelResearchers, for some studies, are demanding the ability to maintain vibrant cultures for long periods of time.Perfusion models afford this, but are expensive, sensitive and require specialized expertise. Given this, I believed it a good time to represent a protocol that can be used for ourprimary neurons and can be extrapolated to many of our other primary and stem cells.Here's the complete protocol.Rose Ludescher, Manager of Customer Satisfaction, is an expert in helping our customers successfully culturing cells. So if you need help with any of your cell-based assays do not hesitate to contact her. Ju...
Source: Neuromics - April 14, 2018 Category: Neuroscience Tags: Cell based assays Cell Cultures cell culturing protocol Neurons Source Type: news

National Eye Institute's 3-D ROC Challenge
Are you Ready?Neuromics is a proudSponsor of this challenge. It enables us to further leverage our potent, proven and published3-D Cell-Based Assay Solutions into drug discovery for eye-related diseases.Our solution set includes 21-CFR Complianthuman primary and stem cells and research ready custom and off the shelf 3-D Models. We also provide defined media and supplements.Neuromics 3-D Blood-Brain Barrier ModelIn addition to models, we offer: ECMS•Engineered hydrogels optimized for cell types•Coming soon: Bio-Inks for 3-D Printing-Engineered for Cells•NanofibersNeuromics ’ HUVECS in an engin...
Source: Neuromics - April 7, 2018 Category: Neuroscience Tags: 3-D Assays. 3-D imaging 3-D Cell based Assays 3-D ROC Challenge Collagen Hydrogels National Eye Insititute Source Type: news

Unmasking Root Causes of Stress/Anxiety
i-Fect Knocks Down Suspected Stress/Anxiety ReceptorThe molecular pathogenesis underlying anxiety disorders is still unclear. Here, the authors demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) overexpression in mice increases spine formation in the amygdala and induces stress hormone upregulation and anxiety-like behaviors. Suppression of MARCKSL1 in the amygdala ameliorates both the increase in stress hormones and the elevated anxiety-like behaviors. Our results indicate that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.This was proved, in part, by t...
Source: Neuromics - March 29, 2018 Category: Neuroscience Tags: Anxiety gene expression analysis i-Fect MARCKSL1 Source Type: news

Give it a Try
You will be SatisfiedOurFBS is growing in popularity over the past year. In follow up with users, we learned that our low price catalyzed their trying, but its potency resulted in high levels of satisfaction.Here are some recent reviews:I enjoyed working with the people at Neuromics. The sale person was very friendly and willing to take extra time to solve our problems. Organization: Mayo User: Wenqian Hu - Oct 15, 2017 - Rating: 5.0 Great Service. Got the products in a very prompt manner! Kemin AgriFoods North AmericaVM - Jul 27, 2017 - Rating: 4.0 Fast and easy supplier to work with! Organization: Fresenius Kab...
Source: Neuromics - March 23, 2018 Category: Neuroscience Tags: FBS Fetal Bovine Serum Source Type: news

Great Growth Factors
Potent and ProvenOurgrowth factors continue to be referenced in leadingpublications.  They are excellent for amping up your stem-cell expansion and differentiation media-Tom Kamperman, Sieger Henke, Claas Willem Visser, Marcel Karperien, Jeroen Leijten. (2017).Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape. Small, doi: 10.1002/smll.201603711.We will continue to post updates. (Source: Neuromics)
Source: Neuromics - March 15, 2018 Category: Neuroscience Tags: BDNF Brain-Derived Neurotrophic Factor FGF Basic FGF2 Fibroblast Growth Factor 2 GDNF Protein Source Type: news

HUVECS in 3-D Action
In this study, the authors developed a 3D functional human microvascular network in a microfluidic device. The established model enables NeuromicsGFP-labeled human umbilical vein endothelial cells to form vessel-like microtissues and have physiological functions which are closer to cells in human blood vessels. The perfusable microvasculature allows the delivery of nutrients, and oxygen, as well as flow-induced mechanical stimuli into the luminal space of the endothelium. The microflow effectively mimic the blood flow in human vessels.Thisin-vivo like model is then used for toxicity assays-Yan Li, Qing-Meng Pi, Peng-Cheng ...
Source: Neuromics - March 2, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D Cell Culturing endothelial cells huvecs Microfluidics Tox assays Source Type: news

Primary Human Astrocytes vs Derived Astrocytes Cell Lines
Potent, Pure and Easy to CultureWe are often asked how ourhuman primary astrocytes stack up versus engineered astrocyte cell lines. Astrocyte cultures, whether primary or engineered, need to mimic how they workin-vivo.This publication is a comprehensive study of the capabilities of our primary astrocytes versus engineered cells. Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, Jos é Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, and Anna Falk. (2018).Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Impro...
Source: Neuromics - February 22, 2018 Category: Neuroscience Tags: astrocyte cultures Astrocyte Markers human Astrocytes iPSCs Source Type: news

i-Fect Delivers Again and Again
This study revealed that LDHA, which is a known damage marker, promotes CNS-specific angiogenesis. LDHA-mediated angiogenesis depends on vimentin on the surface of vascular endothelial cells. The work described here proposes a novel mechanism by which neurodegeneration drives angiogenesis in the CNS.A mixture of ouri-FectTM and LDHA siRNA, in this study, were directly injected into mice cortexes: Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita.Extracellular Lactate Dehydrogenase A Release ...
Source: Neuromics - February 19, 2018 Category: Neuroscience Tags: angiogenesis Delivering siRNA to the CNS Lactate Hydrogenase A LDHA Neurodegenerative Disease siRNA delivery in-vivo Source Type: news

iPSC Derived Human Neural Progenitors
Potent, Pure and Easy to CultureWe are pleased to announce the addition of HumanNeural Progenitors to ourPrimary and Stem Cell offering.Human Neural Progenitors at 95% ConfluencyCell potency, for us, includes the how well our cells can be differentiated into terminal types. For these progenitors, we have protocols for differentiating into neurons, astrocytes, and oligodendrocytes.Neural Progenitors differentiated into Neurons and Stained with Tuj-1We also have Neural Progenitors from Alcohol and Opioid-Addicted Donors. (Source: Neuromics)
Source: Neuromics - February 15, 2018 Category: Neuroscience Tags: astrocyte cultures Astrocytes Culturing Human Neurons Protocol Human Neural Progenitors Neuroprogenitors Oligodendrocytes Source Type: news

Culturing Cells in Defined 3-D Structures
In this study, the authors present in-air microfluidics (IAMF), a new chip-free platform technology that enables in-flight (that is, on-the-fly) formation of droplets, fibers, and particles and their one-step deposition into 3D constructs with a modular internal architecture.Figure: Concept of IAMF and guide to the article. (A) Chip-based microfluidics enables in-line control over droplets and particles, making it a versatile platform technology. A chip design where droplets (blue) are transported by a coflow (pink) is shown. (B) IAMF maintains the in-line control of chip-based microfluidics but relies on jet ejection and ...
Source: Neuromics - February 7, 2018 Category: Neuroscience Tags: 3-D Bioprinting 3-D Cell based Assays Bio-inks Fibroblast Growth Factor Basic Human Mesenchymal Stem Cells ISOKine FGF Source Type: news

Human Hepatocytes
From Healthy and Diseased DonorsWe continue to addhuman primary and derived cells important to your research.We now haveHuman Hepatocytes. They come from healthy and drug-addicted donors.Like all our cells, these are potent, pure and easy to culture.iPSC Derived HeptocytesHuman HepatocytesHC4230  Cell Assays1,000,000 Cells$795.00Human HepatocytesHC4230  Cell Assays500,000 Cells$595.00Human Hepatocytes - Alcohol AddictedHC4230AA  Cell Assays1,000,000 Cells$895.00Human Hepatocytes - Alcohol AddictedHC4230AA  Cell Assays500,000 Cells$695.00Human Hepatocytes - Opioid AddictedHC4230OP&nbs...
Source: Neuromics - February 4, 2018 Category: Neuroscience Tags: Human Heptaocytes iPSCs Source Type: news

Studying Apoptosis
By Cancer Researchers OurApoptosis Kits have proven rock solid in the hands of cancer researchers.Here's data from a study of the impact of Vestibular schwannoma (VS) on hearing loss.Images: Spiral Ganglion Cells labeled with our polycaspase kit stain to identify apoptotic cells. (Source: Neuromics)
Source: Neuromics - January 31, 2018 Category: Neuroscience Tags: Apoptosis Assays Apoptosis Detection Polcaspase Kits Spiral Ganglion Cells Vestibular Schwannoma Source Type: news

Culturing Neurons on Conductive Biomaterials
In this study, researchers successfully culture ourcortical neurons onNonfunctionalized graphene nanosheets (NGN): Shiyun Meng, Rong Peng. Growth and Follow-Up of Primary Cortical Neuron Cells on Nonfunctionalized Graphene Nanosheet Film. Article first published online: January 18, 2018. Spray-coating a nonfunctionalized graphene nanosheet (NGN) on a glass slide. To fix the NGN onto the glass slide, polyurethane (PU) was firstly spin-coated onto glass slides as a polymer matrix, then NGN particles were spray-coated on by airbrush.Figure: Nuclei formed in 7 and 14 days of cell c...
Source: Neuromics - January 23, 2018 Category: Neuroscience Tags: conductive biomaterials e-18 Primary Rat Neurons graphene Source Type: news

Cells from Diseased Donors
Focus on Neuro Diseases We now have the capability to provide cells of the central and peripheral nervous system from donors with Neuro diseases. These include cells from donors with ALS, AD, PD, and Brain Cancer Donors, to name a few.We have provided cells to virtually all the large Pharmas and many small and mid-size Bio-techs. We have worked with Novartis to gain 21-CFR compliance for cells that they are using for their eye diseases drug discovery programs.I am at your “beck and call” should you have interested in exploring specific capabilities further. You can e-mail or call me at 612-801-1007 (Source: Neuromics)
Source: Neuromics - January 15, 2018 Category: Neuroscience Tags: 3-D Cell based Assays ALS Alzheimer ' s Disease Amyotrophic Lateral Sclerosis glioblastomas Parkinson Source Type: news

Microvascular Endothelial Cells
Tested, Characterized and Research ReadyOurMicrovascular Endothelial Cells continue to work and work in the hands of our customers.Check out these pubs:1. Odunayo O. Mugisho, Colin R. Green, Jie Zhang, Nicolette Binz, Monica L. Acosta, Elizabeth Rakoczy and Ilva D. Rupentha. (2017).Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int. J. Mol. Sci. doi: 10.3390/ijms18122567 2. Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. (2015).Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relev...
Source: Neuromics - January 9, 2018 Category: Neuroscience Tags: Diabetic retinopathy endothelial cells human microvascular endotothelial cells Human Retinal Microvascular Endothelial Cells Source Type: news

Medical Grade Soluble Collagen
This study developed a macroporous scaffold that is fabricated by weaving highly aligned collagen threads. The scaffold can deliver high density cell condensates while providing mechanical stiffness comparable to that of cartilage. The scaffold also mimicked the arcade-like orientation of collagen fibers in cartilage. A highly robust chondrogenesis was observed in this mesenchymal cell pellet delivery system. Baseline mechanical robustness of this scaffold system will enable delivery of cell pellets as early as three days. (Source: Neuromics)
Source: Neuromics - January 3, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D collagen scaffolds cartilage human chondrocytes Human Mesenchymal Stem Cells Source Type: news

Cell to Cell Signaling and Depression
This study also features the use of our excellentGFAP markersAbstract: Extracellular ATP is a widespread cell-to-cell signaling molecule in the brain, where it functions as a neuromodulator by activating glia and neurons. Although ATP exerts multiple effects on synaptic plasticity and neuro-glia interactions, as well as in mood disorders, the source and regulation of ATP release remain to be elaborated. Here, we define Calhm2 as an ATP-releasing channel protein based on in vitro and in vivo models. Conventional knockout and conditional astrocyte knockout of Calhm2 both lead to significantly reduced ATP concentrations, loss...
Source: Neuromics - December 21, 2017 Category: Neuroscience Tags: ATP release Depression Glia Glia Markers Neurons Source Type: news

Big Thank You!
Big YearWe exceeded our goals for 2017. By a lot. Both in sales and new products.I would like to personally thank our customers, collaborators, and friends for making this happen. You made it happen.I wish Joy to you in 2018!I wish you exciting, new discoveries, and adventures.Pete Shuster, CEO and Owner, Neuromics. (Source: Neuromics)
Source: Neuromics - December 13, 2017 Category: Neuroscience Tags: Neuromics Source Type: news

Coming Soon Hepatocytes and CSCS
Differentiated from iPSCs Neuromics is partnering withJaveen Biosciences to bring you Cancer Stem Cells and Hepatocytes derived from donor Induced Pluripotent Stem Cells.Rodney Nash, Javeen CEO, and his team are working to fill a major gap in cell-based drug discoveries. The lack of cells from specific diseased or ethnic populations. This limits the ability to predict how well a drug candidate will work with a diverse population of patients.Dr. Rodney Nash, CEO, Javeen BiosciencesOver time, we envision Javeen Biosciences as having the ability to engineer cells from donors that match tightly with the needs of drug hunters.W...
Source: Neuromics - December 8, 2017 Category: Neuroscience Tags: Cancer Stem Cells Drug Discovery Hepatocytes Source Type: news

Need Cells? Contest is Now Live
It's Easy! Creatively insert your favoritehuman cell culture(s) anywhere into a picture of your lab for $25 Amazon Gift Card. To enter, email the picture to with a description of the image that includes your name, the lab name and the type of cells being cultured.First 100 entries are eligible for the gift card.Grand prize is $500 Visa Gift Card. Only entries that include the culture of Neuromics cells will be eligible for the grand prize.Official Contest Rules: Only one entry per lab. The first 100 entries are eligible. Cells cultured do not have to be Neuromics cells to be elig...
Source: Neuromics - November 29, 2017 Category: Neuroscience Tags: 3-D Cell based Assays Human Stem Cells needcells primary human cells Source Type: news

Need Cells? Contest
We're live; Be CreativeWe are offering a $25 Amazon Gift Card to scientists who creatively places images their favorite cell cultures anywhere in a picture of their lab AND if the picture has images ofour human cells, you could win a $500 VISA card.Here's a link to learn more about our Need Cells Contest.Please email your picture and we will email you a $25 Amazon Gift Card. (Source: Neuromics)
Source: Neuromics - November 21, 2017 Category: Neuroscience Tags: Cell Cultures needcells primary human cells Source Type: news

Coming Soon-Need Cells? Contest
Creativity RewardedWe are revving up another contest as ourNeuromics Brain Adventure was successful and wow, were people creative.We are expert at finding humanprimary and stem cells so cell cultures are central to the contest. Rules are simple. Affix an image of your favorite cell culture anywhere in your lab and we will email you a $25 Amazon gift card.The contest will run for 3 months and the most creative entry will receive a $500 Visa Gift Card.Simply e-mail your entry to and we will email back the gift card. Multiple entries encouraged. (Source: Neuromics)
Source: Neuromics - November 16, 2017 Category: Neuroscience Tags: astrocyte cultures Astrocyte-Glial-Neuron Co-cultures. endothelial cells needcells Source Type: news

More FBS Data!
Cells+Media Supplemented with our FBS!We continue to be pleased with the cell culture images our customers are sharing with us- are notoriously hard to culture. Here're images of Mouse Neurons cultured in media supplemented with our FBS.Images: Mouse cortical neurons in culture, using Neuromics heat-inactivated FBS (in plating media for two days). Data courtesy of Dr. Saif at Barrow Neurological Institute.We continue to offer $50 Amazon Gift Card in return for data you share using any of our solutions. Just email the data to Rose Ludescher, Manager of Customer Satisfaction,rose@neur...
Source: Neuromics - November 6, 2017 Category: Neuroscience Tags: Cell based assays FBS Fetal Bovine Serum Neurons Source Type: news

3-D Retina Organoid Challenge
Proud SponsorThe National Eye Institute has its sights set on stimulating researchers to move rapidly toward treatments for retinal diseases. We need your scientific expertise: compete in a Challenge to develop a physiologically-competent3-D retina organoid model.Check us out on theirSponsor's Page. (Source: Neuromics)
Source: Neuromics - October 23, 2017 Category: Neuroscience Tags: 3-D Retinal Organoids Human Retinal Microvascular Endothelial Cells NEI Source Type: news

More Neuromics' FBS Related Data
Cells Cultured in Media Supplemented with our FBSCustomers continue submitting data. Here's the latest:Primary mouse vascular smooth muscle cells stained with smooth muscle alpha-actin in DMEM with Neuromics10% FBS. Image courtesy of Deng-Fu Guo, University of Iowa.HEK Cells Grown in Neuromics FBS. Image courtesy of Kavita Shah, Purdue University.We will continue be posting new FBS related data here. (Source: Neuromics)
Source: Neuromics - October 12, 2017 Category: Neuroscience Tags: FBS Fetal Bovine Serum HEK Cells Smooth Muscle Cells Source Type: news

Neuromics' FGF-2 for Expanding Human Cells
FGF-2 and Fibrochondrocytes FGF-2 of FGF-basic is an important a growth factor for manycell-based assays. Neuromics'has rock solidFGFs for supplementing media used to grow cells. Check outpublications referencing use of FGF-2.Here's the latest publication: Yan Liang, Enaam Idrees, Stephen H. J. Andrews, Kirollos Labib, Alexander Szojka, Melanie Kunze, Andrea D. Burbank, Aillette Mulet-Sierra, Nadr M. Jomha& Adetola B. Adesida.Plasticity of Human Meniscus Fibrochondrocytes: A Study on Effects of Mitotic Divisions and Oxygen Tension. Scientific Reports 7, Article number: 12148 (2017) doi:10.1038/s41598-017-12096-x. ...
Source: Neuromics - September 30, 2017 Category: Neuroscience Tags: FGF Basic FGF Basic Recombinant Protein FGF2 Fibroblast Growth Factor 2 Fibroblast Growth Factor Basic fibroblasts ISOKine ISOKineFGF Source Type: news

i-Fect Delivers Plasmids!
Important for Gene Expression Studies.I have posted many examples of how our customers usei-FectTM  and otherTransfection Solutions for Gene Manipulation Studies. There are also manypublications.Here we feature how i-Fect was used to delivery plasmids to the CNS: Sara Elramah, Mar ía José López-González, Matthieu Bastide, Florence Dixmérias, Olivier Roca-Lapirot, Anne-Cécile Wielanek-Bachelet, Anne Vital, Thierry Leste-Lasserre, Alexandre Brochard, Marc Landry& Alexandre Favereaux.Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone ...
Source: Neuromics - September 21, 2017 Category: Neuroscience Tags: Bone Cancer Pain cancer biology iFect Plasmids Transfection Reagents Source Type: news

Dynamics of Stem Cell Differentiation
Differentiation MarkersNeuromics hasexcellent markers for determining stem cell differentiation.This new publication references use of ourOTX2 marker: Sumin Jang, Sandeep Choubey, Leon Furchtgott, Ling-Nan Zou, Adele Doyle, Vilas Menon, Ethan B Loew, Anne-Rachel Krostag, Refugio A Martinez, Linda Madisen, Boaz P Levi, Sharad Ramanathan.Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states. eLife 2017;6:e20487. DOI: Single-Cell Gene Expression Profiling of mESCs during early germ layer ...
Source: Neuromics - September 16, 2017 Category: Neuroscience Tags: OTX-2 antibody Otx2 Antibody Stem Cell Differentiation Stem Cell Differentiation Protocol Stem cell markers Source Type: news

Neuronal Markers
New Pub References 3 MarkersWe are recognized for our large catalog ofneuronal markers. Our strength, in this area, includes markers designed for pain researchers.They are widely used and frequently published. This new publication references use of ourGuinea Pig Substance P,Guinea Pig PGP9.5 andChicken NF200 of NF-Heavy. andla, Jagadeesha, Lomada, Santosh Kumara, Jianninga; Kuner, Rohinia, Bali, Kiran Kumar.miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels. Pain: September 2017 - Volume 158 - Issue 9 - p 1765 –1779 doi: 10.1097/j.pain.0000000000000971....
Source: Neuromics - September 1, 2017 Category: Neuroscience Tags: Neurofilament Antibody Neurofilament-H Antibody Neuronal Markers PGP9.5 Antibody Protein Gene Product 9.5 Substance P Antibody Source Type: news

FBS Works Great for Cell Lines
More Customer DataWe are pleased with the continuing stream of positive feedback on our potentFBS. This includes its supplementing media for cell lines.Here is an image courtesy of Kavita Shah of Purdue University.Image: HEK Cells cultured in Media Supplemented with Neuromics'FBSWe offer the best price anywhere. We will beat all competitive pricing. If you are interested, contact Rose Ludescher, Manager of Customer Satisfaction. email: (Source: Neuromics)
Source: Neuromics - August 31, 2017 Category: Neuroscience Tags: FBS Fetal Bovine Serum HEK Cells Source Type: news

Data Trifecta-Cells, Media + FBS
Optimizing your Cell-Based AssaysResearchers need solid proof that the solutions the use will work in their assays. Given the time and effort it takes to culture human primary cells, it is important that the media and supplements used are optimized.We engineer our cell media and supplements to work with our primary and stem cells. Its potency is tested every day in our cell cultures.As further proof, we ask customers to share their data with us. We reward them by emailing a 50 USD Amazon gift card. I would like to recognize Emily Rodela from TGEN for sharing the Trifecta ofNeuromics'CAFS grown inMSC-Gro Media suppleme...
Source: Neuromics - August 21, 2017 Category: Neuroscience Tags: CAFs Cancer Associated Fibroblasts FBS Fetal Bovine Serum MSCgro Pancreatic CAF-Stellate Cells Source Type: news

Neuromics' ISOKine bFGF in 3-D Cultures
Works Well in Perfusion ModelsOurISOKineTM FGF is produced in the endosperm tissue of barley grain (Hordeum vulgare), that exhibits up to 50 times less protease activity than E.coli or mammalian cells. Barley seed is void of any human or animal viral contaminants that could jeopardize your cell culture.It is a proven solution for all cell cultures and starts at the low price of 65 USD/10 ug.Here's a reference of its use in 3-D Cultures: Tom Kamperman, Sieger Henke, Claas Willem Visser, Marcel Karperien, Jeroen Leijten.Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Pr...
Source: Neuromics - August 14, 2017 Category: Neuroscience Tags: FGF Basic FGF Basic Recombinant Protein Fibroblast Growth Factor 2 Fibroblast Growth Factor Basic ISOKineFGF Stem cell cultures Source Type: news

Cancer Associated Fibroblasts in Action
Publication ReferenceWe introduced ourCancer Associated Fibroblasts to researchers several years ago. The demand was strong from day one and continues to grow.We are pleased to announce the first reference in a Cancer Research Publication: Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y Lim, Ana L Gomes, Paul Kinchesh, Sean C Smart, W. Gillies McKenna, Francesca M Buffa, Owen J. Sansom, Ruth J. Muschel, Eric O'Neill and Emmanouil Fokas.Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Published OnlineFirst August 1, 2017 doi: 10.1158...
Source: Neuromics - August 9, 2017 Category: Neuroscience Tags: CAFs Cancer Associated Fibroblasts pancreas cancer Pancreatic CAF-Stellate Cells pancreatic cancer Pancreatic tumor cells Source Type: news