Neuromics' Human Neurons in Action
Our primary human neurons (cat. HNC001) have been busy lately, continuing to become one of our most popular and versatile products. Earlier this month, Japanese researchers published their findings when creating 3D brain-like spheroids containing our primary human neurons. Their results suggest the spheroids mimic in vivo conditions and are suitable for use as an in vitro neurological disease model. Check out the publication for yourself here.Human Neurons in CultureSince the beginning of 2022, our neurons have been cited a number of times spanning various research are...
Source: Neuromics - July 29, 2022 Category: Neuroscience Source Type: news

Potent and Pure Fetal Bovine Serum
Potent and pure FBS. Single use, triple filtered and manufactured under the strictest guidelines, Pricing starts at $245/500 mlCheck us out Fetal Bovine Serum. (Source: Neuromics)
Source: Neuromics - April 20, 2022 Category: Neuroscience Source Type: news

Introducing our Prostate Cancer Cells Lines
 Check out the OptionsNeuromics is pleased to introduce many of the top human prostate cancer cell lines to our already expansive selection of cell offerings. To complement the DU 145 cells we added earlier this year, Neuromics is now offering VcaP, LNCaP, and PC-3 cells to complete our catalog of human prostate cancer cell lines.Image: VcaP cells in culture.VCaP cells are known for their high androgen receptor and PSA expression. Unlike most other prostate cancer cell lines,LNCaP cells are highly sensitive to androgens and have a low tumorigenicity. Meanwhile,PC-3 cells are noted for their high metastatic potential a...
Source: Neuromics - February 15, 2022 Category: Neuroscience Tags: cancer prostate cancer Tumor tumor cells Source Type: news

Neuromics' Human Brian Microvascular Endothelial Cells in Action
Fc-saxatilin inhibits VEGF-induced permeability by regulating claudin-5 expression in human brain microvascular endothelial cells (HBMVECs)Neuromics ' cells were at the heart of this study.Highlights: Fc-saxatilin prevents VEGF-induced permeability in human brain microvascular cells (HBMVECs). Fc-saxatilin inhibits VEGF-induced Src and Fak phosphorylation in HBMVECs. Fc-saxatilin blocks the downregulation of claudin-5 expression by VEGF in HBMVECs.Image: HMBECS in CultureProtocol: Human brain microvascular endothelial cells (HBMVECs) were purchased from Neuromics (HEC02; Minneapolis, MN, USA). HBMVECs were m...
Source: Neuromics - January 25, 2022 Category: Neuroscience Tags: human brain microvascular cells Human microvascular endothelial cells Source Type: news

TRPV1 and Migraines
Conclusion-the present findings indicate that insulin may activate TRPV1 receptors in the trigeminovascular system. Modified TRPV1 receptor function induced by insulin may also increase the sensitivity of both neural and vascular TRPV1 receptor for its agonists. Our data may provide a pathophysiological basis for the increased incidence of migraine in patients with hyperinsulin levels. (Source: Neuromics)
Source: Neuromics - January 21, 2022 Category: Neuroscience Source Type: news

About IBA Lifesciences
IBA Lifesciences ' proprietary Strep-tag ® technology exploits one of the strongest non-covalent interactions in nature: the interaction of biotin and streptavidin. The system is based on the highly selective and easily controllable interaction between the synthetic Strep-tag®II peptide and the specially engineered streptavidin, called S trep-Tactin®, which is one of the most stable proteins known. The Strep-tag®II binds specifically to the engineered streptavidins, Strep-Tactin® and Strep-Tactin®XT, by occupying the binding pocket of the natural ligand biotin. Hence, the interaction is easily reversible by excessive...
Source: Neuromics - December 31, 2021 Category: Neuroscience Source Type: news

Studying Diabetic Retinopathy?
Check out How Neuromic ' s Tools Are UsedThe authors used four of Neuromics to complete this study-Sulodexide reduces glucose induced senescence in human retinal endothelial cellsA. Gericke, K. Suminska-Jasi ńska& A. Br ęborowicz Scientific Reports volume 11, Article number: 11532 (2021) Cite this article.Material and MethodsExperiments were performed on HREC (#HEC09, Neuromics, Edina, MN, USA) in in vitro culture. Cells were seeded in 75 cm2 culture flasks coated with AlphaBioCoat Solution (#AC00, Neuromics, Edina, MN, USA) and were grown in Endo Growth Medium (EKG001, Neuromics, Edina, MN, USA) supplemented with fe...
Source: Neuromics - November 24, 2021 Category: Neuroscience Tags: Cell Detachment Diabetic retinopathy Human Endothelial Cells Human Retinal Microvascular Endothelial Cells Hyperglycemia Source Type: news

Neuromics' FBS and National Cancer Institutes
 Best Price and Performance I was honored to work with Jessey at National Cancer Institute (NCI).The were determining whether to change partners. According to Jessey, there were 24 lab PIs who would be supplied with the winner ' s FBS Although we proved competitive, we were not selected.The study was uconducted with only premium grade FBS (most expensive). We are announcing a new Preferred FBS this Monday 10/25. It works well for supplementing define media and works great for most human primary sells. And works fabulous for human and animal cancer cells.Interested in learning more? Contact me at pshuster@neuromic...
Source: Neuromics - October 23, 2021 Category: Neuroscience Tags: Bone Cancer Pain Cancer Associated Fibroblasts cell biology FBS Fetal Bovine Serum national cancer Institute Source Type: news

Neuromics-3D Human Blood Brain Barrier!
Compound Penetration Study   Classification: Low permeability: Pe< 1.00 nm/s Moderate permeability: 1.00< Pe< 10.0 nm/s High permeability: Pe> 10.0 nm/s * The signal responses of Atenolol , Sulpiride, and Cimetidine in receiver samples were undetectable.For the convenience of calculation, 1/300 of the measured peak area ratio (PAR) of the relevant AD (A>B Donor) samples were used as the PAR values of Atenolol , Sulpiride, and Cimetidine in receiver samples.Check out the study-https://www.neuromics.com/ittrium/reference/D8xf65cx8x1/BBB%20Penetration%20Data.pdf ...
Source: Neuromics - October 6, 2021 Category: Neuroscience Source Type: news

Neuromics' Renal Proximal Tubule Cells in Action
In this study, ourRPT Cells were used to study the impact of Klothko expression on protection of kidneys in diabetics: Meng Xue, Feng Yang, Ying Le, Yanlin Yang, Bingsen Wang, Yijie Jia, Zongji Zheng, and Yaoming Xue. (2021).Klotho Protects Against Diabetic Kidney Disease via AMPK- and ERK-Mediated Autophagy. Acta Diabetologica, 32. doi: 10.1007/s00592-021-01736-4.Klotho expression in human renal proximal tubule cells after high-glucose stimulation. (a) Levels of Klotho mRNA and (b) Klotho protein were assessed in human renal proximal tubule cells treated with low glucose and high glu- cose. (c) Morphological observat...
Source: Neuromics - June 3, 2021 Category: Neuroscience Source Type: news

Trigeminal Neuralgia (Facial Pain)
 Markers for Pain ResearchTrigeminal Neuralgia is a progress chronic condition. Dysfunctional trigeminal signaling can lead to intense, searing facial pain. It is caused by pressure on the trigeminal nerve.The root causes of the condition are not well understood. Ourpain research markers have been widely used and frequently published through the years and have been important contributors to our growth, Here ' s a recent pub referencing use of one ourP2X3 Antibodies-Momoko Koizumi, Sayaka Asano, Akihiko Furukawa, Yoshinori Hayashi, Suzuro Hitomi, Ikuko Shibuta, Katsuhiko Hayashi, Fusao Kato, Koichi Iwata, and Masamichi...
Source: Neuromics - May 27, 2021 Category: Neuroscience Tags: Craniofacial pain P2X3 Antibody P2X3 Receptor Antibody Trigeminal Neurons Source Type: news

Malaria and the Blood-Brain Barrier
 EPCR and ICAM ReceptorsNeuromicsAstrocytes and Pericytes were used in this important study-Yvonne Adams, Rebecca W. Olsen, Anja Bengtsson, Nanna Dalgaard, Mykola Zdioruk, Sanghamitra Satpathi, Prativa K. Behera, Praveen K. Sahu, Sean E. Lawler, Klaus Qvortrup, Samuel C. Wassmer, and Anja T.R. Jensen. (2021).Plasmodium Falciparum Erythrocyte Membrane Protein 1 Variants Induce Cell Swelling and Disrupt the Blood –Brain Barrier in Cerebral Malaria. Journal of Experimental Medicine, 218 (3). doi: 10.1084/jem.20201266.This is the first study showing malaria pericytes interacting with human endothelial cells. Please note...
Source: Neuromics - February 1, 2021 Category: Neuroscience Tags: 3-D Blood-Brain Barrier Model –brain barrier penetration brain microvascular endothelial cells human Astrocytes Human Endothelial Cells Human Pericytes Source Type: news

Human Schwann Cells that Work
 No Doubt!Sometimes we hear our human cells did not express a certain receptor in the hands of our customers. We guarantee our cell " walk and talk " as advertised. If you are ever in doubt. we will test for expression of any receptors or cytoplasmic proteins. We also do this as part of our quality checks.Here ' re, for example, is a pub showing our Schwann Cells working. Note the receptors tested here. Seung Min Shin, Francie Moehring, Brandon Itson-Zoske, Fan Fan, Cheryl L. Stucky, Quinn H. Hogan, and Hongwei Yu. (2021). Piezo2 Mechanosensitive Ion Channel is Located to Sensory Neurons and Non-Neuronal Cells in Rat ...
Source: Neuromics - January 26, 2021 Category: Neuroscience Tags: chronic pain human primary primary human cells Schwann Cell Markers Schwann Cells Source Type: news

Cancer Associated Fibroblasts (CAFS) Traction Dynamics and Remodeling in 3D Matrices
 Neuromics ' Colorectal CAFS in ActionIn a first of its kind study, the mechanical properties of ourCAFS were determined. This is important because, understanding how these cell behavein vivowill help improve the efficacy of new therapies: Bashar Emon, Zhengwei Li, Md Saddam Hossain Joy, Umnia Doha, Farhad Kosari, and M Taher A Saif. (2020).A Novel Method for Sensor-Based Quantification of Single/Multi-Cellular Traction Dynamics and Remodeling in 3D Matrices. bioRxiv. doi: 10.1101/2020.09.24.311647" Cells in vivo generate mechanical forces (traction) on surrounding 3D extra cellular matrix (ECM) and cells. Such tracti...
Source: Neuromics - November 25, 2020 Category: Neuroscience Tags: 3-D Assays. 3-D imaging CAFs Cancer Associated Fibroblasts colorectal CAFs Colorectal Cancer Source Type: news

Neuromics' n-Fect Delivers
 Gene Expression Tools in ActionNeuromics has a wide offering of transfection reagents that are perfect for both in vivo and in vitro applications. We take pride in seeing our product used in research, which is certainly true of our transfection reagents (see here).Furthermore, we ' d like to highlight a recent use of our n-Fect Transfection Kit (cat.# NF30150) in a doctoral thesis recently published. The paper looked into the neuroscience of alcohol addiction, looking towards the purinergic family receptor P2X4, which has been linked to alcohol addiction in mouse...
Source: Neuromics - October 23, 2020 Category: Neuroscience Tags: gene expression analysis p-Fect Transfection Source Type: news