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Editorial: Porphyromonas gingivalis: molecular mechanisms of invasion, immune evasion, and dysbiosis
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research

Antimicrobial and antibiofilm effects of essential fatty acids against clinically isolated vancomycin-resistant Enterococcus faecium
ConclusionDHA showed the strongest antibacterial activity, while GLA showed the strongest antibiofilm effect among the EFAs with antibacterial activity. Our novel findings indicate that the antibiofilm activity of GLA may be through down-regulating the atlA gene expression in VRE-fm. Therefore, DHA and GLA had the potential to be developed as therapeutic agents to treat infections related to multiple antimicrobial-resistant E. faecium. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research

Microbiome –transcriptome analysis reveals that dietary supplementation with macleaya cordata extract alters multiple immune pathways with minimal impact on microbial structure
ConclusionCollectively, the analysis of microbiome–transcriptome data revealed that dietary supplementation with MCE produced significant alterations in multiple immune pathways, while having minimal impact on the microbial structure. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research

A rapid and high-throughput multiplex genetic detection assay for detection, semi-quantification and virulence genotyping of Helicobacter pylori in non-invasive oral samples
ConclusionThe non-invasive HMGA proved to be a reliable method for the rapid H. pylori identification, semi-quantification and detection of 10 virulence genes directly in oral samples, providing a new idea for non-invasive detection of H. pylori. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research

An insight into the functional alterations in the gut microbiome of healthy adults in response to a multi-strain probiotic intake: a single arm open label trial
ConclusionIn healthy young adults, overall alpha- and beta-diversity did not change in response to probiotic intake even though modest compositional changes at the family and genus level were observed. However, at functional level, results identified changes in gene abundance for several functional pathways. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research

Characterization of changes in the intestinal microbiome following combination therapy with zinc preparation and conventional treatment for children with rotavirus enteritis
ConclusionCompared with the conventional therapy alone, the combined therapy with the zinc preparation significantly improves symptoms caused by RV. The combination therapy containing the zinc preparation significantly increases the diversity and abundances of some beneficial groups of bacteria. Further, The presence of these groups was further negatively correlated with relevant inflammatory factors. More importantly, this combination therapy containing the zinc preparation provides a reference for the clinical management of children with RV enteritis. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research

Case Report: Omadacycline in the treatment of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in an adolescent patient
Omadacycline is a novel tetracycline antibiotic that exhibits good in vitro antibacterial activity against atypical pathogens such as Mycoplasma pneumoniae. It is approved for the treatment of adults with community-acquired bacterial pneumonia. However, the safety and efficacy of omadacycline in pediatric patients under 18 years of age have not yet been established. In the present paper, we report a case of pediatric community-acquired pneumonia in which initial empirical anti-infective therapy had failed. The patient received empirical anti-infective therapy with azithromycin and other antimicrobial agents upon admission ...
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research

Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy
IntroductionThe emergence of resistance and interference mechanisms to phage infection can hinder the success of bacteriophage-based applications, but the significance of these mechanisms in phage therapy has not been determined. This work studies the emergence of Salmonella isolates with reduced susceptibility to a cocktail of three phages under three scenarios: i) Salmonella cultures (LAB), ii) biocontrol of cooked ham slices as a model of food safety (FOOD), and iii) oral phage therapy in broilers (PT).MethodsS. Typhimurium ATCC 14028 RifR variants with reduced phage susceptibility were isolated from the three scenarios...
Source: Frontiers in cellular and infection microbiology - September 28, 2023 Category: Microbiology Source Type: research

Parathyroid hormone therapy improves MRSA-infected fracture healing in a murine diabetic model
DiscussionOur results suggest that teriparatide may constitute a viable adjuvant therapeutic agent to improve bony union and bone microarchitecture to prevent the development of septic nonunion under diabetic conditions. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 27, 2023 Category: Microbiology Source Type: research

The immune evasion roles of Staphylococcus aureus protein A and impact on vaccine development
While Staphylococcus aureus (S. aureus) bacteria are part of the human commensal flora, opportunistic invasion following breach of the epithelial layers can lead to a wide array of infection syndromes at both local and distant sites. Despite ubiquitous exposure from early infancy, the life-long risk of opportunistic infection is facilitated by a broad repertoire of S. aureus virulence proteins. These proteins play a key role in inhibiting development of a long-term protective immune response by mechanisms ranging from dysregulation of the complement cascade to the disruption of leukocyte migration. In this review we descri...
Source: Frontiers in cellular and infection microbiology - September 27, 2023 Category: Microbiology Source Type: research

Covert dissemination of pLVPK-like virulence plasmid in ST29-K54 Klebsiella pneumoniae: emergence of low virulence phenotype strains
This study aimed to explore the epidemic, clinical characteristics, and molecular and virulence attributes of Klebsiella pneumoniae serotype K54 (K54-Kp). A retrospective study was conducted on 328 strains of Klebsiella pneumoniae screened in a Chinese hospital from January 2016 to December 2019. The virulence genes and antibiotic resistance genes (ARGs) were detected by PCR, and a drug sensitivity test was adopted to detect drug resistance. Multilocus sequence typing (MLST) and PFGE were performed to determine the clonal correlation between isolates. Biofilm formation assay, serum complement-mediated killing, and Galleria...
Source: Frontiers in cellular and infection microbiology - September 27, 2023 Category: Microbiology Source Type: research

Revealing a causal relationship between gut microbiota and lung cancer: a Mendelian randomization study
ConclusionsOur results confirm a causal relationship between specific gut microbiota and lung cancer, providing new insights into the role of gut microbiota in mediating the development of lung cancer. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 27, 2023 Category: Microbiology Source Type: research

IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest
DiscussionIgM antibodies against different Plasmodium spp. antigens are present in NP from the Atlantic Forest. High seroprevalence and antibody levels against blood-stage antigens were observed, which had a significant association with molecular evidence of infection. IgM antibodies against CSP and AMA-1 may be used as a potential marker for the identification of NP infected with Plasmodium, which are reservoirs of malaria in the Brazilian Atlantic Forest. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 27, 2023 Category: Microbiology Source Type: research

Editorial: Mechanisms during bacterial infection: cellular recognition, signalling, and regulation
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 26, 2023 Category: Microbiology Source Type: research

Editorial: Antimicrobial resistance in pediatric infectious diseases: antimicrobial resistance, resistance mechanisms and antimicrobial use
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 26, 2023 Category: Microbiology Source Type: research