Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies
ConclusionGut microbiota dysbiosis was demonstrated in IgAN, which might be involved in the pathogenesis of IgAN. Further studies are needed to confirm the findings of this study, due to the substantial heterogeneity.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier PROSPERO (CRD42022304034). (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - May 17, 2022 Category: Microbiology Source Type: research

The Activity of Liposomal Linolenic Acid Against Helicobacter pylori In Vitro and Its Impact on Human Fecal Bacteria
In conclusion, LipoLLA showed good anti-H. pylori effects. It destroyed the outer membrane barrier and caused leakage of the bacterial contents to achieve anti-H. pylori effects. And LipoLLA had little effect on human fecal bacteria in vitro. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - May 17, 2022 Category: Microbiology Source Type: research

An Anti-MRSA Phage From Raw Fish Rinse: Stability Evaluation and Production Optimization
Accumulating evidence has denoted the danger of resistance in tenacious organisms like methicillin-resistant Staphylococcus aureus (MRSA). MRSA, a supple bacterium that adopts a variety of antibiotic resistance mechanisms, is the cause of multiple life-threatening conditions. Approaching a post-antibiotic era, bacteria-specific natural predators, bacteriophages, are now given the chance to prove eligible for joining the antibacterial weaponry. Considering the foregoing, this study aimed at isolating bacteriophages with promising anti-MRSA lytic activity, followed by characterization and optimization of the production of th...
Source: Frontiers in cellular and infection microbiology - May 17, 2022 Category: Microbiology Source Type: research

“Alterations in the Skin Microbiota Are Associated With Symptom Severity in Mycosis Fungoides”
Cutaneous T cell lymphoma (CTCL), a non-Hodgkin lymphoma, is thought to arise from mature tissue-resident memory T cells. The most common subtypes include Mycosis Fungoides and Sezary Syndrome. The role of skin microbiota remains unclear in the symptom manifestation of MF. Among 39 patients with MF, we analyzed bacteria colonizing MF lesions and non-lesional skin in the contralateral side and characterized regional changes in the skin microbiota related to MF involvement using the difference in relative abundance of each genus between lesional and contralateral non-lesional skin. We investigated the relationship between th...
Source: Frontiers in cellular and infection microbiology - May 17, 2022 Category: Microbiology Source Type: research

Editorial: Identification and Characterization of Novel Antigens of Malarial Parasites
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

Analysis of Negative Results of Metagenomics Next-Generation Sequencing in Clinical Practice
ConclusionsThe present data indicate that when the mNGS test is negative, the negative prediction accuracy rate of the original specimen is significant. However, other laboratory assays results and clinical presentations should always be carefully considered prior to drawing a diagnosis. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study
ConclusionIbrexafungerp showed a potent in vitro activity against Candida. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

Features of Epstein –Barr Virus and Cytomegalovirus Reactivation in Acute Leukemia Patients After Haplo-HCT With Myeloablative ATG-Containing Conditioning Regimen
ConclusionWe concluded that EBV and CMV reactivations were frequent in acute leukemia patients after haplo-HCT, with possibly distinctive risk factors from HLA-matched HCT. There could be a potential interaction between EBV and CMV, but impacts on transplant outcomes remained complex. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

Augmented Enterocyte Damage During Candida albicans and Proteus mirabilis Coinfection
The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally interacts with residing bacteria. We investigated fungal-bacterial interactions by coinfecting enterocytes with the yeast Candida albicans and the Gram-negative bacterium Proteus mirabilis resulting in enhanced host cell damage. This synergistic effect was conserved across different P. mirabilis isolates and occurred also with non-albicans Candida species and C. albicans m...
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

G Protein-Coupled Receptors as Potential Intercellular Communication Mediators in Trypanosomatidae
Detection and transduction of environmental signals, constitute a prerequisite for successful parasite invasion; i.e., Leishmania transmission, survival, pathogenesis and disease manifestation and dissemination, with diverse molecules functioning as inter-cellular signaling ligands. Receptors [i.e., G protein-coupled receptors (GPCRs)] and their associated transduction mechanisms, well conserved through evolution, specialize in this function. However, canonical GPCR-related signal transduction systems have not been described in Leishmania, although orthologs, with reduced domains and function, have been identified in Trypa...
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

Bacterial Adhesion and Biofilm Formation of Enterococcus faecalis on Zwitterionic Methylmethacrylat and Polysulfones
Biofilm-associated implant infections represent a major challenge for healthcare systems around the world due to high patient burden and enormous costs incurred. Enterococcus faecalis (E. faecalis) is the most prevalent enterococcal species identified in biofilm-associated infections. The steadily growing areas of application of implants demand a solution for the control of bacterial infections. Therefore, the development of modified anti-microbial implant materials and the testing of the behavior of different relevant bacterial strains towards them display an indispensable task. Recently, we demonstrated an anti-microbial...
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

E3 Ligase FBXW7 Facilitates Mycobacterium Immune Evasion by Modulating TNF- α Expression
Tumor necrosis factor alpha (TNF-α) is a crucial factor in the control of Mycobacterium tuberculosis (Mtb) infection. Pathogenic mycobacteria can inhibit and/or regulate host cell TNF-α production in a variety of ways to evade antituberculosis (anti-TB) immunity as well as facilitate immune escape. However, the mechanisms by which TNF-α expression in host cells is modulated to the benefit of mycobacteria is still an interesting topic and needs further study. Here, we report that macrophages infected with Mycobacterium marinum (Mm)—a close relative of Mtb—upregulated the expression of E3 ubiquitin ligase FBXW7. Speci...
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota
Several strains of lactic acid bacteria are potent probiotics and can cure a variety of diseases using different modes of actions. These bacteria produce antimicrobial peptides, bacteriocins, which inhibit or kill generally closely related bacterial strains and other pathogenic bacteria such as Listeria, Clostridium, and Salmonella. Bacteriocins are cationic peptides that kill the target cells by pore formation and the dissipation of cytosolic contents, leading to cell death. Bacteriocins are also known to modulate native microbiota and host immunity, affecting several health-promoting functions of the host. In this review...
Source: Frontiers in cellular and infection microbiology - May 16, 2022 Category: Microbiology Source Type: research

Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives
Mycoplasmas as economically important and pantropic pathogens can cause similar clinical diseases in different hosts by eluding host defense and establishing their niches despite their limited metabolic capacities. Besides, enormous undiscovered virulence has a fundamental role in the pathogenesis of pathogenic mycoplasmas. On the other hand, they are host-specific pathogens with some highly pathogenic members that can colonize a vast number of habitats. Reshuffling mycoplasmas genetic information and evolving rapidly is a way to avoid their host’s immune system. However, currently, only a few control measures exist agai...
Source: Frontiers in cellular and infection microbiology - May 13, 2022 Category: Microbiology Source Type: research

Accurate 16S Absolute Quantification Sequencing Revealed Vaginal Microecological Composition and Dynamics During Mixed Vaginitis Treatment With Fufang FuRong Effervescent Suppository
ConclusionFufang Furong Effervescent Suppository can be as effective as clindamycin cream in the management of AV+BV while may restore the vagina microecosystem better. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - May 13, 2022 Category: Microbiology Source Type: research